Universiti Putra Malaysia.

PROF. DR.
HAMIDON BASRI
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UNDERSTANDING CHOLINE METABOLISM IN ATHEROSCLEROTIC PLAQUES
AND IN SECONDARY CAUSES OF ABNORMAL GLUCOSE METABOLISM AS A
SURROGATE MARKER OF IMPENDING STROKE FOR THE DEVELOPMENT OF
NOVEL BIOMARKER PROBE IN ASSOCIATION WITH CLINICAL AND GENETIC
PARAMETERS
PROF HAMIDON BASRI
Department of Medicine,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia.
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Project members
Stroke in
Malaysia
Prof Dr Hamidon Basri
Dept of Medicine
Prevalence
Clinical risk factors
Assoc Prof Dr Ahmad Fazli, Dr Norzian:
Dept of Medicine
Dr Ching Siew Moi, Dept of Family Med
Neuroimaging
Prof Dato Dr Abdul Jalil Nordin
Dr Subapriya Suppiah , PPDN
Assoc Prof Fathinul Fikri, PPDN
Dr. Hoo Fan Kee, Dr Joseph, Dr Ng, Dr Sazlina:Dept of
Medicine; Dr Iskasymar, Emergency Med
Molecular
genetics
Assoc Prof Cheah Yoke Kqueen
Dr Suman Lal
Biochemistry
Assoc Prof Dr Norhafizah
Mohktarruddin
Prof Johnson Stanlas (Pharmacology
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and Therapeutics)
Background
Stroke is the third commonest cause of
death among Malaysians. The commonest
type is ischaemic stroke, usually
secondary to atherosclerotic disease
caused by uncontrolled hypertension.
Choline metabolism has a role in the
inflammation process in the pathogenesis
of the formation of atherosclerotic
plaques and subsequent plaque rupture.
Choline metabolism can be studied using
18F-choline PET/CT scan imaging.
Furthermore it can act as a surrogate
marker for non-invasively correlating
important clinical and proteomic factors
that contribute to impending stroke.
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• Several studies have been conducted to assess
the carotid arteries, which are the large vessels
supplying blood to the brain.
• However, in Malaysian population, it is the
thrombosis of small vessels in the brain that is
the major cause of stroke. Studies pertaining to
this are lacking.
• In addition, there is a need to explore possibility
of choline as a biomarker of inflammation, which
can be tagged with medication to deliver targeted
therapy to prevent plaque rupture.
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Objectives
• 1. To investigate choline metabolism in atherosclerotic
plaques and other secondary causes of abnormal glucose
metabolism, which are involved in the pathophysiology of
stroke
• 2. To identify associated clinical and genetic risk factors
involved in causing stroke, using 18F-choline PET/CT scan as
a non-invasive surrogate marker
• 3. To ultimately create a computer software tailored to
Asian population that helps stratify and prognosticate
stroke
• 4. To determine possibility of creating choline-tagged
medication that can deliver targeted therapy to prevent
atherosclerotic plaque rupture
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Methodology
• A randomized prospective study to assess risk
factors in Malaysians who had a recent stroke
using 18F-choline PET/CT imaging compared
to conventional Magnetic Resonance imaging
• To correlate the PET/CT findings with clinical,
biochemical and genetic parameters for the
risk stratification and prognostication of stroke
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ASSOC. PROF. DR.
CHEAH YOKE KQUEEN
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TITLE : Signature miRNAs
expression, networks and
interaction of various cancer
(Name of project leader) :
Assoc. Prof. Dr. Cheah Yoke Kqueen
Department of Biomedical Science
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia.
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Cancer is a complex disease that contribute to the major cause of mortality and
morbidity. MicroRNAs (miRNAs) are critical regulators of gene expression and
influence numerous cancer-relevant processes such as proliferation, cell cycle control,
apoptosis, differentiation, migration and metabolism. This study aims to profile and
characterize miRNA expression and regulation in various common cancers such as
lung, breast, head and neck, colorectal and prostate. There is lack of integrated
information on a specific miRNA expression, regulation among these cancers and also
naturally occurring cancer in animals.
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Establishing the relationship of Genetic Signatures of Non-coding RNAs with
Quantification value of micro Coronary Circulation as potential predictive
Theranostic Markers for early preclinical asymptomatic high risk group for
developing coronary artery disease.
Assoc. Prof. Dr. Cheah Yoke Kqueen BMS PHD
Prof. Dato’ Dr. Abdul Jalil Nordin MD M.Radiology
Assoc. Prof. Dr. Ahmad Fazli MD M.Medicine
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia.
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Project description
•
Ischemic Heart Disease (IHD) is one of the leading causes in mortality. Non-coding
RNAs including microRNAs (miRNAs) and long non-coding RNA (lncRNAs) had been
reported associated with (IHD) and potentially useful as theranostic markers. Our
research team unravel 20 differentially expressed miRNA and 10 novel miRNAs
associated with IHD patients. So far, no study conducted for the association of the
Positron Emission Tomography (PET) for quantifying myocardial blood flow (MBF)
in the coronary artery microcirculation with non-coding RNAs
Theranostic and Predictive
Markers for Coronary Artery
Disease
Quantitative
PETCT imaging
Molecular &
Bioinformatics
Prof. Dato Dr. Abdul
Jalil Nordin
AP Dr. Cheah Yoke
Kqueen
(UPM, PPDN)
(UPM, MGI)
Prediction &
Prognostics
AP Dr. Ahmad Fazli
Abdul Aziz (UPM, Hosp
Serdang, IJN)
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DR. NURAINUL HANA
SHAMSUDDIN
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DNA methylation profiling to
identify epigenetic dysregulation in
emotionally distressed Asian adult with
type 2 diabetes mellitus.
(Dr Nurainul Hana Shamsuddin)
Department of Family Medicine,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia.
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This study aims to determine psychological factors effect on DNA methylation of selected genes involved in
chronic immune/inflammatory processes and inflammation-related endothelial dysfunction in the Asian adults
with T2DM. Such epigenetic dysregulation may represent biological pathways that mediate the effects of
psychological factors on diabetes-related complications. The results of this study is expected to give a strong
motivation for psychosocial support initiatives Asian adults with T2DM.
Malaysian adults with
T2DM
EDDMQoL Cohort
AP Dr. Chew Boon How &
AP Dr. Sazlina Shariff-Ghazali
Department of Family Medicine, FMHS, UPM
Psychological factors
DNA methylation profiling
Dr. Cheah Pike See,
Dr. Aaron Fernandez,
Dr. Thilakavathy Karrupiah &
Department of Psychiatry, FMHS, UPM
Dr. Micheal KH Ling
Medical Genetics Labroratory, FMHS, UPM
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DR. GEETA APPANNAH
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Randomised Control Trial on
Childhood Obesity at Malaysian
Primary Care Setting
Dr Geeta Appannah, PhD (Cantab)
Department of Nutrition and Dietetics
Faculty of Medicine and Health Sciences
Universiti Putra Malaysia
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Summary
1. More likely to
obese as adults & at
higher risk of CVD
5. No structured
intervention studies
with a long period of
follow-up have been
conducted in
Malaysia
4. Primary care level
is accessible to
families across most
social gradient &
could provide
continuous
relationship
2. Effective early life
prevention or
intervention
strategies are crucial
Childhood
obesity
3. Incorporating
interdisciplinary
approaches are
found to be more
substantial
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Western dietary patterns, genetic
predisposition and obesity risk among
Malaysian young people
Dr Geeta Appannah, PhD (Cantab)
Department of Nutrition and Dietetics
Faculty of Medicine and Health Sciences
Universiti Putra Malaysia
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Summary
Greater adherence to the a specific dietary pattern i.e. Western, characterised by a high intake of red and
processed meats, refined grains, high-fat milk, sugar sweetened beverages and confectionery was associated with
increased risk of obesity in young people
Obesity is a product of the interplay between genetic and lifestyle factors
It is possible that high intakes of Westernised diets are more likely to increase the risk of obesity among
those with higher genetic susceptibility to this disease
Such evidence of gene-diet/lifestyle interactions on the development of obesity is sparse, particularly in
young people
Identification of gene-diet/lifestyle interactions early in life will generate a better understanding of the
causal pathways that lead to obesity
To examine the potential interactions between the genetic predisposition to obesity defined by the wellestablished genetic variants and empirically derived dietary patterns in relation to obesity risk in a large
observational study of Malaysian children
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ASSOC. PROF. DR.
LEE PING YEIN
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TITLE :
Development and Pilot testing of a “My
Healthy Plate” application for smartphones in
empowering patients with diabetes mellitus for
diet monitoring
(Name of project leader) : Associate Prof Dr Lee Ping Yein
Department of Family Medicine,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia.
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Project description (include figures, if possible)
•
Background : An app that capture image of food and calculate calories automatically would
probably improve compliance to diet for diabetes patients.
- Data of common food images
Phase 1 – Pre-application
development Dr Nurfadhlina Mohd. Sharef
Department of computer science, UPM
Phase 2 – Development of the
application
Associate Professor Dr Chan Yoke Mun
Department of Nutrition and Dietetics, UPM
- Usage of app
- Adherence of calories
target
- Glyceamic control
- Weight reduction
Phase 3 –Evaluation of the
effectiveness of the application in
diabetes patients.
Associate Professor Dr Lee Ping Yein
Department of Family Medicine, UPM
Expected outcomes:
• Provide good evidence of the feasibility of using mobile phone to disseminate
health information and helping patients in self-care of chronic diseases.
• The My Healthy app can be used to apply to the community to encourage
individuals to monitor their diet.
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Potential collaboration
• Expert needed in this area:
- Image capturing and analysis in smartphone
application.
- Smartphone application development programmer
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PROF. DR. LEKHRAJ
RAMPAL
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Comprehensive Translational Novel Research in
Non-Communicable Diseases in Perak Malaysia
Faculty of Medicine
and Health Sciences
Ministry of Education Malaysia
Ministry of Health Malaysia
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PROGRAM :
Comprehensive Translational Novel Research
in Non-Communicable Diseases, Malaysia
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GOAL
A HEALTHY AND PROSPEROUS NATION
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Background and justification, problem
statement, fundamental research questions,
significance and impact
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Implementation of NSP-NCD: Perspective from the
Causation Pathway for NCD
Underlying
Determinants
•Globalisation
•Urbanisation
•Population
Ageing
Common Risk
Factors
•Unhealthy diet
•Physical Inactivity
•Tobacco & Alcohol use
•Age (non modifiable)
•Heredity
(non modifiable)
Intermediate
Risk Factors
•Overweight/
obesity
•Raised blood sugar
•Raised blood
pressure
•Abnormal blood
lipids
Main NCD
•Heart Disease
•Diabetes
•Stroke
•Cancer
•Chronic resp.
diseases
The NCD epidemic can only be effectively managed via:
•
•
•
At the environmental level, through policy and regulatory interventions;
At the level of common and intermediate risk factors, through population-based lifestyle
interventions; and
At the level of early and established disease, through clinical interventions targeted at
high-risk individuals.
30
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IMPACT ON THE NATION
13 DECEMBER 2011
2011 National Morbidity Survey show that the Risk Factors Continue to Rise
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IMPACT ON THE NATION
STAR 16TH December 2011
2011 National Morbidity Survey show that the Risk Factors Continue toPutraOCW
Rise
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Upstream interventions
Policies/
lack of it in
other
sectors
Treating
individuals
with NCD
DO WE WANT TO REMAIN FLOOR MOPPERS OR BE TAPPutraOCW
TURNERS
PROJECT 1
A Comprehensive Behavioral Modification
Intervention for Non- Communicable Disease (NCD)
Risk Factors
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PROJECT 2
Assessment of Socio-economic impact of NCD on
individual and families
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PROJECT 3
Deciphering the immune modulation status of
NCD disease patients: A holistic approach in
treating cardiovascular disease
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PROJECT 4
Policy development for a Comprehensive Tobacco,
E-Cig, Vape and Shisha Control Program
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THANK YOU
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