Older Sircol Assay Citations

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Sircol Citations
2015
Murine Aneuploid Fibrosarcoma Cell Line (L929)
Aramwit, P., & Jaichawa, N. (2015). A comparative study of type A and type B gelatin nanoparticles as the
controlled release carriers for different model compounds. Materials Express 5, 241 – 248. Retrieved from
http://www.ingentaconnect.com/content/asp/me/2015/00000005/00000003/art00009
Human Carotid Plaques
Asciutto, G., Dias, N., Edsfeldt, A., & Nitulescu, M. (2015). Low elastin content of carotid plaques is associated
with increased risk of ipsilateral stroke. PloS One doi: 10.1371/journal.pone.0121086. Retrieved from
http://dx.plos.org/10.1371/journal.pone.0121086
Bone Marrow-Derived Mesenchymal Stem Cells
Ba, R., Wei, J., Li, M., & Cheng, X. (2015). Cell-bricks based injectable niche guided persistent ectopic
chondrogenesis of bone marrow-derived mesenchymal stem cells and enabled nasal augmentation. Stem
Cell Research & Therapy 6, 16. Retrieved from http://www.biomedcentral.com/content/pdf/s13287-0150006-4.pdf
Human Airways
Balenga, N., Klichinsky, M., & Xie, Z. (2015). A fungal protease allergen provokes airway hyper-responsiveness in
asthma. Nature Communications 6, Article Number 6763. Retrieved from
http://www.nature.com/ncomms/2015/150413/ncomms7763/full/ncomms7763.html
Human Mesenchymal Stem Cells
Barati, D., & Walters, J. (2015). Effect of Organic Acids on Calcium Phosphate Nucleation and Osteogenic
Differentiation of Human Mesenchymal Stem Cells on Peptide Functionalized Nanofibers. Langmuir doi:
10.1021/acs.langmuir.5b00615. Retrieved from
http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.5b00615
Boda, S., Thrivikraman, G., & Basu, B. (2015). Magnetic field assisted stem cell differentiation–role of substrate
magnetization in osteogenesis. Journal of Materials Chemistry B 3, 3150 – 3168. Retrieved from
http://pubs.rsc.org/en/content/articlehtml/2015/tb/c5tb00118h
Human Orbital Fibroblasts
Bo-ding, T., Man-Yi, X., Jie-Xi, Z., & Wei, X. (2015). MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroidassociated ophthalmopathy. Molecular Vision 21, 324 – 334. Retrieved from
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384173/
Mouse Lung
Bronova, I., & Smith, B. (2015). Peripheral Targeting of CB1 Cannabinoid Receptors Protects from RadiationInduced Pulmonary Fibrosis. American Journal of Resp Cell Mol Biol. doi:
10.1165/rcmb.2014.03310c. Retrieved from http://www.atsjournals.org/doi/abs/10.1165/rcmb.20140331OC
Human and Mouse Lung Samples
Calhoun, C. (2015). Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. The Journals of
Gerontology A Biol Sci Med Sci doi: 10.1093/Gerona/glu241/. Retrieved from
http://biomedgerontology.oxfordjournals.org/content/early/2015/01/07/gerona.glu241.short
Human Bone Marrow-Derived Mesenchymal Stem Cells
Castro, N., Patel, R., & Zhang, L. (2015). Design of a Novel 3D Printed Bioactive Nanocomposite Scaffold for
Improved Osteochondral Regeneration. Cellular and Molecular Bioengineering doi: 10.1007/s12195-0150389-4. Retrieved from http://link.springer.com/article/10.1007/s12195-015-0389-4
Mouse Fibroblasts
Chang, B., Choi, Y., & Kim, J. (2015). Collagen complexes increase the efficiency of iPS cells generated using
fibroblasts from adult mice. Journal of Reproduction and Development 2, 145 – 153. Retrieved from
http://doi.org/10.1262/jrd.2014-081.
Human Annulus Fibrosus Cells
Chen, M., Sun, J., & Liao, S. (2015). Low-intensity pulsed ultrasound stimulates matrix metabolism of human
annulus fibrosus cells mediated by transforming growth factor β 1 and extracellular signal-regulated kinase
pathway. Connective Tissue Research doi: 10.3109/03008207.2015.1016609. Retrieved from
http://informahealthcare.com/doi/abs/10.3109/03008207.2015.1016609
Human Skin Fibroblasts
Chiang, H., & Chan, S. (2015). Fisetin ameliorated photodamage by suppressing the MAP kinase/MMP pathway and
NF-κB pathways. Journal of Agricultural and Food Chemistry doi: 10.1021/jf502500t. Retrieved from
http://pubs.acs.org/doi/abs/10.1021/jf502500t
Primary Cardiac Fibroblasts
Chichger, H., & Vang, A. (2015). PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism
of RV fibrosis in pulmonary hypertension. American Journal of Physiology Lung Cellular and Molecular
Physiology 308, L827 – L836. Retrieved from http://ajplung.physiology.org/content/308/8/L827.abstract
Human Nasal Polyp-Derived Fibroblasts
Cho, J., Kang, J., & Shin, J. (2015). Inhibitory Effect of Delphinidin on Extracellular Matrix Production via the
MAPK/NF-κB Pathway in Nasal Polyp-Derived Fibroblasts. Allergy, Asthma & Immunol. Res. 7, 276 – 282.
Retrieved from
http://synapse.koreamed.org/search.php?where=aview&id=10.4168/aair.2015.7.3.276&code=0166AAIR&vm
ode=FULL
Dog Hind Leg Wound
Das, J., Nath, I., & Routray, P. (2015). Cell-based therapy and rehabilitation with prosthetic limbs in a dog. Turkish
Journal of Veterinary and Animal Sciences 39, 115 – 119. Retrieved from
http://mistug.tubitak.gov.tr/bdyim/abs.php?dergi=vet&rak=1404-95
Chondrocytes
Díaz-Rodríguez, P., & Landin, M. (2015). Controlled release of indomethacin from alginate–poloxamer–silicon
carbide composites decrease in-vitro inflammation. International Journal of Pharmaceutics 480, 92 – 100.
Retrieved from http://www.sciencedirect.com/science/article/pii/S0378517315000344
Cardiac Fibroblasts
Dong, X., Liu, S., Zhang, L., & Yu, S. (2015). Downregulation of miR‐21 is Involved in Direct Actions of Ursolic Acid
on the Heart: Implications for Cardiac Fibrosis and Hypertrophy. Cardiovascular Therapeutics doi:
10.1111/1755-5922.12125. Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/17555922.12125/abstract
Rat Liver
Douhara, A., & Moriya, K. (2015). Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic
stellate cell activation and remission of intestinal permeability in a rat non-alcoholic. Molecular Medicine
Reports 11, 1693 – 1700. Retrieved from http://www.spandidos-publications.com/mmr/11/3/1693
Neonatal Rat Lung
Drummond, S., Ramachandran, S., & Torres, E. (2015). CXCR4 Blockade Attenuates Hyperoxia-Induced Lung Injury
in Neonatal Rats. Neonatology 107, 304 – 311. Retrieved from
http://www.karger.com/Article/Abstract/371835
Guinea Pig Dermal Wound
Farahani, F., & Fattahian, H. (2015) Experimental Study on Ostrich Acellular Dermal Matrix in Repair of FullThickness Wounds of Guinea Pig. Kafkas Univ Vet Fak Derg doi: 10.9775/kvfd.2015.13212. Retrieved from
http://vetdergi.kafkas.edu.tr/inpress/13212.pdf
Mouse Lung
Fattah, E., & Bhattacharya, A. (2015). Critical Role for IL-18 in Spontaneous Lung Inflammation Caused by
Autophagy Deficiency. The Journal of Immunology doi: 10.4049/jimmunol.1402277. Retrieved from
http://www.jimmunol.org/content/early/2015/04/17/jimmunol.1402277.short
Human Colonic Subepithelial Myofibroblasts
Fotiadis, K., Filidou, E., & Arvanitidis, K. (2015). Intraperitoneal application of phospholipids for the prevention of
post-operative adhesions: a possible role of myofibroblasts. Journal of Surgical Research doi:
http://dx.doi.org/10.1016/j.jss.2015.04.036. Retrieved from
http://www.sciencedirect.com/science/article/pii/S002248041500431X
Human Lung Fibroblasts
Fu, C., Odegaard, J., & Hsieh, M. (2015). Macrophages are required for host survival in experimental urogenital
schistosomiasis. The FASEB Journal 29, 193 – 207. Retrieved from
http://www.fasebj.org/content/29/1/193.short
Rat Submandibular Glands
Gao, Z., Wu, T., Xu, J., Liu, G., Xie, Y., & Zhang, C. (2015). Generation of Bioartificial Salivary Gland Using WholeOrgan Decellularized Bioscaffold. Cells Tissues Organs doi: 10.1159/000371873. Retrieved from
http://www.karger.com/Article/Abstract/371873
Porcine Dermis
Greco, K., & Francis, L. (2015). Characterisation of porcine dermis scaffolds decellularised using a novel nonenzymatic method for biomedical applications. Journal of Biomaterials Applications doi:
10.1177/0885328215578638. Retrieved from
http://jba.sagepub.com/content/early/2015/04/08/0885328215578638.abstract
Green, D., Kwon, H., & Jung, H. (2015). Osteogenic Potency of Nacre on Human Mesenchymal Stem Cells. Molecules
and Cells 38, 267 – 272. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363727/
Human Periodontal Ligament Cells
Hasegawa, D., & Wada, N. (2015). Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells
through TGFβ1‐mediated Upregulation of Periostin Expression. Journal of Cellular Physiology doi:
10.1002/jcp.24950. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/jcp.24950/abstract
Mouse Skin
Herro, R., & Antunes, R. (2015). The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte
Activity and Skin Fibrosis. Journal of Investigative Dermatology doi: 10.1038/jid.2015.110. Retrieved from
http://www.nature.com/jid/journal/vaop/ncurrent/full/jid2015110a.html
Horie, M., Saito, A., & Yamaguchi, Y. (2015). Three-dimensional Co-culture Model for Tumor-stromal Interaction.
JoVE (Journal of Vis. Exp.) 96, e52469. Retrieved from http://www.jove.com/video/52469/threedimensional-co-culture-model-for-tumor-stromal-interaction
Mouse Lung
House, J., Li, H., DeGraff, L., & Flake, G. (2015). Genetic variation in HTR4 and lung function: GWAS follow-up in
mouse. The FASEB Journal 29, 323 – 335. Retrieved from http://www.fasebj.org/content/29/1/323.short
Human Dermal Fibroblasts and Mouse Skin
Huang, J., Beyer, C., & Palumbo-Zerr, K. (2015). Nintedanib inhibits fibroblast activation and ameliorates fibrosis
in preclinical models of systemic sclerosis. Annals of the Rheumatic Diseases doi: 10.1136/annrheumdis2014-207109. Retrieved from http://ard.bmj.com/content/early/2015/04/09/annrheumdis-2014207109.short
Human Liver Cell Line (HepG2)
Hussein, K., & Park, K. (2015). Three dimensional culture of HepG2 liver cells on a rat decellularized liver matrix
for pharmacological studies. Journal of Biomedical Marterials Research doi: 10.1002/jbm.b.33384.
Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33384/full
Mouse MMP19-/- Lung Fibroblasts
Jara, P., Calyeca, J., & Romero, Y. (2015). Matrix metalloproteinase (MMP)-19 deficient fibroblasts display a
profibrotic phenotype. American Journal of Physiology Lung Cellular and Molecular Physiology doi:
10.1152/ajplung.00043.2014. Retrieved from
http://ajplung.physiology.org/content/early/2015/01/09/ajplung.00043.2014.abstract
Rat Tail Collagen
Kadziński, L. (2015). Effect of Silicone on the Collagen Fibrillogenesis and Stability. Journal of Pharmaceutical
Sciences doi: 10.1002/jps.24351. Retrieved from
http://onlinelibrary.wiley.com/doi/10.1002/jps.24351/full
Mouse Renal Tissue
Kamata, M., Hosono, K., & Fujita, T. (2015). Role of cyclooxygenase-2 in the development of interstitial fibrosis in
kidneys following unilateral ureteral obstruction in mice. Biomedicine & Pharmacotherapy doi:
10.1016/j.biopha.2015.01.010. Retrieved from
http://www.sciencedirect.com/science/article/pii/S0753332215000256
Karimi, T., Barati, D., & Karaman, O. (2015). A developmentally inspired combined mechanical and biochemical
signaling approach on zonal lineage commitment of mesenchymal stem cells in articular cartilage.
Integrative Biology 7, 112 – 127. Retrieved from
http://pubs.rsc.org/en/content/articlehtml/2014/ib/c4ib00197d
Mouse Lung
Karmouty-Quintana, H., Philip, K., & Acero, L. (2015). Deletion of ADORA2B from myeloid cells dampens lung
fibrosis and pulmonary hypertension. The FASEB Journal 29, 50 – 60. Retrieved from
Mouse Skin
Kavian, N., Marut, W., & Servettaz, A. (2015). Pantethine prevents murine systemic sclerosis in the mouse through
the inhibition of microparticle shedding. Arthritis & Rheumatology doi: 10.1002/art.39121. Retrieved from
http://onlinelibrary.wiley.com/doi/10.1002/art.39121/abstract
Human Adipose-Derived Stem Cells
Kim, S., & Jung, Y. (2015). TGF-β 3 encapsulated PLCL scaffold by a supercritical CO 2–HFIP co-solvent system for
cartilage tissue engineering. Journal of Controlled Release 206, 101 – 107. Retrieved from
Human Dermal Fibroblast Cells
Kim, Y., Huh, J., Lim, Y., & Cho, M. (2015). Soy Isoflavone Glycitin (4’‐Hydroxy‐6‐Methoxyisoflavone‐7‐D‐Glucoside)
Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF‐β Signaling. Phytotherapy
Research doi: 10.1002/ptr.5313. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/ptr.5313/full
Human Allogeneic Vein Valves From Cadavers
Kuna, V., Rosales, A., & Hisdal, J. (2015). Successful tissue engineering of competent allogeneic venous valves.
Journal of Vascular Surgery: Venous and Lymphatic Disorders doi: 10.1016/j.jvsv.2014.12.002. Retrieved
from http://www.sciencedirect.com/science/article/pii/S2213333X15000049
Porcine Tracheal Scaffolds and Human Tracheae
Lange, P., & Greco, K. (2015). Pilot study of a novel vacuum‐assisted method for decellularization of tracheae for
clinical tissue engineering applications. Journal of Tissue Engineering and Regenerative Medicine doi:
10.1002/term.1979. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/term.1979/full
Mouse Lung
Lee, D., Walker, S., Byrne, A., & Gregory, L. (2015). Perinatal paracetamol exposure in mice does not affect the
development of allergic airways disease in early life. Thorax doi: 10.1136/thoraxjnl-2014-205280. Retrieved
from http://thorax.bmj.com/content/early/2015/04/03/thoraxjnl-2014-205280.full?g=w_thorax_open_tab
Bovine Joint Articular Chondrocytes
Lee, J., Gegg, C., & Hu, J. (2015). Thyroid hormones enhance the biomechanical functionality of scaffold-free
neocartilage. Arthritis Research & Therapy 17, 28. Retrieved from
http://www.biomedcentral.com/content/pdf/s13075-015-0541-5.pdf
Human Ileal Strictures
Li, C., Iness, A., & Yoon, J. (2015). Noncanonical STAT3 Activation Regulates Excess TGF-β1 and Collagen I
Expression in Muscle of Stricturing Crohn’s Disease. The Journal of Immunology 194, 3422 – 3431. Retrieved
from http://www.jimmunol.org/content/194/7/3422.short
Human Asthma Surrogate
Li, Y., Wang, W., Huang, P., Zhang, Q., & Yao, X. (2015). Distinct sustained structural and functional effects of IL‐
33 and IL‐25 on the airways in a murine asthma surrogate. Immunology doi: 10.1111/imm.12465.
Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/imm.12465/abstract
Human Osteoblast-Like Saos-2 Cells
Liskova, J., & Babchenko, O. (2015). Osteogenic cell differentiation on H-terminated and O-terminated
nanocrystalline diamond films. International Journal of Nanomedicine 10, 869 – 884. Retrieved from
Fibroblasts and Epithelial Cells
Lumsden, R., & Worrell, J. (2015). Modulation of pulmonary fibrosis by IL-13Rα2. American Journal of Physiology
Lung Cellular and Molecular Physiology 308, L710 – L718. Retrieved from
http://ajplung.physiology.org/content/308/7/L710.abstract
Mouse Fibroblasts
Mallano, T., & Palumbo-Zerr, K. (2015). Activating transcription factor 3 regulates canonical TGFβ signalling in
systemic sclerosis. Annals of the Rheumatic Diseases doi: 10.1136/annrheumdis-2014-206214. Retrieved
from http://ard.bmj.com/content/early/2015/01/14/annrheumdis-2014-206214.short
Harbour Porpoise Temporomandibular Joint
McDonald, M., & Vapniarsky-Arzi, N. (2015). Characterization of the temporomandibular joint of the harbor
porpoise (Phocoena phocoena) and Risso’s dolphin (Grampus griseus). Archives of Oral Biology 60, 582 –
592. Retrieved from http://www.sciencedirect.com/science/article/pii/S0003996915000126
Mice Carrying Human Pancreatic Tumour
Meng, H., Wang, M., Liu, H., Liu, X., Situ, A., & Wu, B. (2015). Use of a Lipid-Coated Mesoporous Silica
Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in
Mice. ACS Nano 9, 3540 – 3557. Retrieved from http://pubs.acs.org/doi/abs/10.1021/acsnano.5b00510
Human Tenocytes
Millar, N., Gilchrist, D., & Akbar, M. (2015). MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon
disease. Nature Communications 6, Article No. 6774. Retrieved from
Human Fibroblasts and Mouse Lung
Mukherjee, S., Ayaub, E., & Murphy, J. (2015). Nifedipine Disrupts Signaling in Fibroblasts and Attenuates
Bleomycin-Induced Fibrosis. American Journal of Cell Mol Biol doi: 10.1165/rcmb.2015-00090c. Retrieved
from http://www.atsjournals.org/doi/abs/10.1165/rcmb.2015-0009OC
Temporomandibular Joint Disc
Murphy, M., & Arzi, B. (2015). Neocartilage integration in temporomandibular joint discs: physical and enzymatic
methods. Journal of The R Soc Interface 12, pii 20141075. Retrieved from
http://rsif.royalsocietypublishing.org/content/12/103/20141075.abstract
Human Lung Adenocarcinoma Cells (A549)
Nakajima, F., & Aratani, S. (2015). Synoviolin inhibitor LS-102 reduces endoplasmic reticulum stress-induced
collagen secretion in an in vitro model of stress-related interstitial pneumonia. International Journal of
Molecular Medicine 35, 110 – 116. Retrieved from http://www.spandidospublications.com/ijmm/35/1/110?text=fulltext
Mouse Heart Tissue
O’Connor, D., Naresh, N., & Piras, B. (2015). A novel cardiac muscle‐derived biomaterial reduces dyskinesia and
postinfarct left ventricular remodeling in a mouse model of myocardial infarction. Physiological Reports 3,
e12351. Retrieved from http://physreports.physiology.org/content/3/3/e12351.abstract
Mouse Lung
Ohnuma, K., Hatano, R., & Aune, T. (2015). Regulation of Pulmonary Graft-versus-Host Disease by IL-26+ CD26+
CD4 T Lymphocytes. The Journal of Immunology 194, 3697 – 3712. Retrieved from
http://www.jimmunol.org/content/194/8/3697.short
Human Lung Tissue and Lung Fibroblasts
Oruqaj, G., & Karnati, S. (2015). Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle
inducing a higher fibrotic response via TGF-β signaling. Proceedings of the National Academy of Sciences
112, E2048 – E2057. Retrieved from http://www.pnas.org/content/112/16/E2048.short
Mouse Skin
Palumbo-Zerr, K., Zerr, P., & Distler, A. (2015). Orphan nuclear receptor NR4A1 regulates transforming growth
factor- signaling and fibrosis. Nature Medicine 21, 150 – 158. Retrieved from
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3777.html
Mouse Lung
Santos, G. Dos, Rogel, M., & Baker, M. (2015). Vimentin regulates activation of the NLRP3 inflammasome. Nature
Communications Article 6574, doi: 10.1038/ncomms7574. Retrieved from
Rat Mesenchymal Stem Cells
Singh, R., Jin, G., & Mahapatra, C. (2015). Mesoporous Silica-Layered Biopolymer Hybrid Nanofibrous Scaffold: A
Novel Nanobiomatrix Platform for Therapeutics Delivery and Bone Regeneration. ACS Applied Materials &
Interfaces 7, 8088 – 8098. Retrieved from http://pubs.acs.org/doi/abs/10.1021/acsami.5b00692
Mouse Cardiac Tissue and Cardiac Fibroblasts
Sklepkiewicz, P., Shiomi, T., & Kaur, R. (2015). Loss of Secreted Frizzled-Related Protein-1 Leads to Deterioration
of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy. Circulation: Heart Failure 8, 362 –
372. Retrieved from http://circheartfailure.ahajournals.org/content/8/2/362.short
Mouse Lung
Sun, B., Wang, X., Ji, Z., Wang, M., Liao, Y., & Chang, C. (2015). NADPH Oxidase‐Dependent NLRP3 Inflammasome
Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes. Small doi:
10.1002/smll.201402859. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/smll.201402859/full
Neonatal Mouse Cardiac Fibroblasts
Sun, F., Duan, W., & Zhang, Y. (2015). Simvastatin alleviates cardiac fibrosis induced by infarction via up‐
regulation of transforming growth factor, beta receptor III expression. British Journal of Pharmacology doi:
10.1111/bph.13166. Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/bph.13166/abstract
Human Denuded Amniotic Membrane
Taghiabadi, E., Nasri, S., & Shafieyan, S. (2015). Fabrication and characterization of spongy denuded amniotic
membrane based scaffold for tissue engineering. Cell J 16, 476 – 487. Retrieved from
http://oaji.net/articles/2015/109-1421148832.pdf
Mouse Lung
Tan, J., Chan, S., & Lo, C. (2015). Amnion cell mediated immune modulation following bleomycin challenge:
controlling the regulatory T cell response. Stem Cell Research & Therapy 6, 8. Retrieved from
http://stemcellres.com/content/6/1/8/abstract
Rat Colon
Tao, Q., Wang, B., & Zheng, Y. (2015). Triptolide ameliorates colonic fibrosis in an experimental rat model.
Molecular Medicine Reports 0, 0-0. http://dx.doi.org/10.3892/mmr.2015.3582. Retrieved from
http://www.spandidos-publications.com/10.3892/mmr.2015.3582
Murine Macrophage Cell Line (RAW264.7 Cells)
Tewtrakul, S., & Tungcharoen, P. (2015). Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L.
Phytotherapy Research doi: 10.1002/ptr.5321. Retrieved from
http://onlinelibrary.wiley.com/doi/10.1002/ptr.5321/full
Mouse Lung
Thompson, E. (2015). STAT1 Attenuates Murine Allergen-Induced Airway Remodeling and Exacerbation by Carbon
Nanotubes. American Journal of Resp. Cell Mol Biol doi: 10.1165/rcmb.2014-02210c. Retrieved from
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2014-0221OC
Human Fibroblasts
Tomcik, M., Palumbo-Zerr, K., & Zerr, P. (2015). Tribbles homologue 3 stimulates canonical TGF-β signalling to
regulate fibroblast activation and tissue fibrosis. Annals of the Rheumatic Diseases doi:
10.1136/annrheumdis-2014-206234. Retrieved from
http://ard.bmj.com/content/early/2015/01/20/annrheumdis-2014-206234.abstract
Mouse Lung Fibroblasts
Trentin, P., & Ferreira, T. (2015). Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of
silica particles in mice. British Journal of Pharmacology doi: 10.1111/bph.13109. Retrieved from
http://onlinelibrary.wiley.com/doi/10.1111/bph.13109/full
Soft-Shelled Turtle Carapace
Wang, C., & Huang, C. (2015). Effects of dietary vitamin C on growth, lipid oxidation, and carapace strength of
soft-shelled turtle, Pelodiscus sinensis. Aquaculture 445, 1 – 4. Retrieved from
Mouse Lung
Wang, X., Duch, M., Mansukhani, N., & Ji, Z. (2015). Use of a Pro-Fibrogenic Mechanisms-Based Predictive
Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials. ACS Nano
doi: 10.1021/nn507243w. Retrieved from http://pubs.acs.org/doi/abs/10.1021/nn507243w
White Rabbit Knee Trochlear Groove/Bone Marrow Cells
Wei, B., Yao, Q., Guo, Y., Mao, F., & Liu, S. (2015). Three-dimensional polycaprolactone–hydroxyapatite scaffolds
combined with bone marrow cells for cartilage tissue engineering. Journal of Biomaterials Appl doi:
10.1177/0885328215575762. Retrieved from
http://jba.sagepub.com/content/early/2015/03/11/0885328215575762.abstract
Pig Medial Femoral Condyle
Wei, B., Zong, M., Yan, C., & Mao, F. (2015). Use of quantitative MRI for the detection of progressive cartilage
degeneration in a mini‐pig model of osteoarthritis caused by anterior cruciate ligament transection. Journal
of Magnetic Resonance Imaging doi: 10.1002/jmri.24862. Retrieved from
http://onlinelibrary.wiley.com/doi/10.1002/jmri.24862/full
Human and Mouse Fibroblasts
Wei, J., Ghosh, A., & Chu, H. (2015). Histone deacetylase SIRT1 is reduced in systemic sclerosis and abrogates
fibrotic responses by targeting TGF‐ß signaling. Arthritis & Rheumatology 67, 1323 – 1334. Retrieved from
http://onlinelibrary.wiley.com/doi/10.1002/art.39061/abstract
Mouse Colon
Weiss, C., Guan, Q., Ma, Y., & Qing, G. (2015). The Potential Protective Role of Caveolin-1 in Intestinal
Inflammation in TNBS-Induced Murine Colitis. PloS One 10, e0119004.. Retrieved from
Wu, C. (2015). Preparation, Characterisation, and Controlled-Release of Biodegradable Polyester and Marine-Algae
Composite. Journal of Polymers and the Environment doi: 10.1007/s10924-015-0712-0. Retrieved from
http://link.springer.com/article/10.1007/s10924-015-0712-0
Human Foreskin Fibroblasts
Wu, C. (2015). Preparation and characterisation of poly (hydroxyalkanoate)/Ganoderma lucidum fibre composites:
mechanical and biological properties. Polymer Bulletin doi: 10.1007/s00289-015-1307-6. Retrieved from
Wu, T., Yang, M., & Hsu, Y. (2015). Improvement of cytocompatibility of polylactide by filling with marine algae
powder. Materials Science and Engineering: C 50, 309 – 316. Retrieved from
Scar Tissue from Laminectomized Rats
Xu, H., Liu, C., & Sun, Z. (2015). CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2
pathway: Potential role in epidural ﬁbrosis. International Journal of Molecular Medicine 0, 0 – 0.
http://dx.doi.org/10.3892/ijmm.2015.2190. Retrieved from http://www.spandidospublications.com/10.3892/ijmm.2015.2190
Human Pulmonary Epithelial Cells
Yamada, A., Aki, T., Unuma, K., Funakoshi, T., & Uemura, K. (2015). Paraquat Induces Epithelial-Mesenchymal
Transition-Like Cellular Response Resulting in Fibrogenesis and the Prevention of Apoptosis in Human
Pulmonary Epithelial Cells. PloS One 10, e0120192. Retrieved from
Rat Skin Wound
Yao, C., Yeh, J., & Chen, Y. (2015). Wound‐healing effect of electrospun gelatin nanofibres containing Centella
asiatica extract in a rat model. Journal of Tissue Engineering and Regenerative Medicine doi:
10.1002/term.1992.med. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/term.1992/full
Equine Decellularised Tendon Scaffolds/Bone Marrow-Derived Mesenchymal Stem Cells
Youngstrom, D., & Rajpar, I. (2015). A bioreactor system for in vitro tendon differentiation and tendon tissue
engineering. Journal of Orthopaedic Research 33, 911 – 918. Retrieved from
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Rat Periodontal Ligament (PDL) Tissue and Human PDL Stem Cells
Yuda, A., Maeda, H., & Fujii, S. (2015). Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic
differentiation of a human periodontal ligament stem/progenitor cell line. Journal of Cellular Physiology
230, 150 – 159. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/jcp.24693/full
Human Muscle-Derived Fibroblasts and Myoblasts
Zanotti, S., Gibertini, S., & Curcio, M. (2015). Opposing roles of miR-21 and miR-29 in the progression of fibrosis in
Duchenne muscular dystrophy. Biochimica et Biophysica Acta (BBA), Molecular Basis of Disease 1852, 1451
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Mouse Liver
Zhang, X., Tan, Z., Wang, Y., & Tang, J. (2015). PTPRO-Associated Hepatic Stellate Cell Activation Plays a Critical
Role in Liver Fibrosis. Cellular Physiology and Biochemistry 35, 885 – 898. Retrieved from
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Mouse Lung
Zhou, B., Flodby, P., Wang, H., Liu, Y., & Minoo, P. (2015). Effects of Endoplasmic Reticulum (ER) Stress on
Epithelial Injury and Fibrosis in Alveolar Epithelial Type II Cell (AT2)-Specific Grp78 Knockout Mice. The
FASEB Journal 29, no. 1 supplement 1015.4. Retrieved from
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Murine Model of Pancreatic Ductal Adenocarcinoma
Aguilera, K., Rivera, L., Hur, H., & Carbon, J. (2014). Collagen signaling enhances tumor progression after antiVEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Research 74, 1032.
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Mesenchymal Stem Cells / Mouse Lung
Akaike, Y., Kurosawa, H., Kikuchi, T., & Ichinose, M. (2014). Mesenchymal Stem Cells Correct Inappropriate
Epithelial Mesenchyme Relation in pulmonary fibrosis using Stanniocalcin-1. Mol Ther doi:
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Fibroblast Cultures
Amara, S., Lopez, K., Banan, B., & Brown, S. (2014). Synergistic effect of pro-inflammatory TNFα and IL-17 in
periostin mediated collagen deposition: Potential role in liver fibrosis. Molecular Immunology 64, 26 – 35.
Porcine Cholecyst (Gall Bladder)
Anilkumar, T. V, Vineetha, V. P., Revi, D., & ... (2014). Biomaterial properties of cholecyst‐derived scaffold
recovered by a non‐detergent/enzymatic method. Journal of biomedical Materials Research Part B: Applied
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Mouse Lung
Arizmendi, N., & Puttagunta, L. (2014). Rac2 is involved in bleomycin-induced lung inflammation leading to
pulmonary fibrosis. Respiratory Research 15, 71. Retrieved from
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Mouse Embryonic and Lung Fibroblasts
Aschner, Y., Khalifah, A. P., Briones, N., Yamashita, C., & ... (2014). Protein Tyrosine Phosphatase α Mediates
Profibrotic Signaling in Lung Fibroblasts through TGF-β Responsiveness. The American Journal of Pathology
184, 1489 – 1502. Retrieved from http://www.sciencedirect.com/science/article/pii/S000294401400090X
Rat Kidney Model
Banon-Maneus, E., Rovira, J., Ramirez-Bajo, M. J., & ... (2014). Wnt Pathway Activation in Long Term Remnant Rat
Model. BioMed Research International, Article ID 324713, 10 pages. Retrieved from
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Marrow Stromal Cells and Endothelial Progenitor Cells
Barati, D., Moeinzadeh, S., Karaman, O., & Jabbari, E. (2014). Time Dependence of Material Properties of
Polyethylene Glycol Hydrogels Chain Extended with Short Hydroxy Acid Segments. Polymer 55, 3894 – 3904.
Mouse Pulmonary Fibroblasts
Barnes, J., & Lumsden, R. (2014). CXCR3 is Required for the IL-13 Mediated Upregulation of IL-13Rα2 in Pulmonary
Fibroblasts. American Journal of Respiratory Cell and Molecular Biology doi: 10.1165/rcmb.2013-0433OC.
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Human and Rodent Lung Parenchyma
Bellaye, P. S., Burgy, O., Colas, J., Fabre, A., & ... (2014). Anti-fibrotic Role of αB-crystallin Inhibition in Pleural
and Subpleural Fibrosis. American Journal of Respiratory Cell and Molecular Biol. doi: 10.1165/rcmb-201400110c. Retrieved from http://www.atsjournals.org/doi/abs/10.1165/rcmb.2014-0011OC
Human and Rodent Lung
Bellaye, P. S., Wettstein, G., Burgy, O., & ... (2014). The small heat‐shock protein αB‐crystallin is essential for the
nuclear localization of Smad4: impact on pulmonary fibrosis. The Journal of Pathology 232, 458 – 472.
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Aged Human Dermal Fibroblasts
Bentov, I., Damodarasamy, M., Plymate, S., & Reed, M. (2014). Decreased proliferative capacity of aged dermal
fibroblasts in a three dimensional matrix is associated with reduced IGF1R expression and activation.
Biogerontology 15, 329 – 337. Retrieved from http://link.springer.com/article/10.1007/s10522-014-9501-8
Human Fibroblasts and Murine sGC Knockout Fibroblasts
Beyer, C., & Zenzmaier, C. (2014). Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking
non-canonical TGFβ signalling. Annals of the Rheumatic Diseases doi: 10.1136/annrheumdis-2013-204508.
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Human Gut Explants
Biancheri, P., Sabatino, A. Di, & ... (2014). Absence of a role for interleukin‐13 in inflammatory bowel disease.
European Journal of Immunology 44, 370 – 385. Retrieved from
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Rat Activated Hepatic Stellate Cells
Birukawa, N. K., Murase, K., Sato, Y., Kosaka, A., & ... (2014). Activated hepatic stellate cells are dependent on
self collagen, cleaved by membrane type 1-matrix metalloproteinase for their growth. Journal of Biological
Chemistry 289, 20209 – 21. Retrieved from
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Mouse Lung
Bitencourt, C., & Gelfuso, G. (2014). Hyaluronidase-loaded PLGA microparticles as a new strategy for the
treatment of pulmonary fibrosis. Tissue Eng. Part A, doi: 10.1089/ten.TEA.2013.0403. Retrieved from
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Mouse Lung
Bode, C., Kinjo, T., Alvord, W. G., & Klinman, D. M. (2014). Suppressive oligodeoxynucleotides reduce lung cancer
susceptibility in mice with silicosis. Carcinogenesis 35, 1078 – 1083. Retrieved from
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Human Osteoblasts
Brie, I., Soritau, O., & Dirzu, N. (2014). Comparative in vitro study regarding the biocompatibility of titanium-base
composites infiltrated with hydroxyapatite or silicatitanate. Journal of Biological Engineering 8, 14.
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Mouse Lung
Cargnoni, A., Piccinelli, E. C., Ressel, L., Rossi, D., Magatti, M., & ... (2014). Conditioned medium from amniotic
membrane-derived cells prevents lung fibrosis and preserves blood gas exchanges in bleomycin-injured
mice—specificity of the effects and insights into possible mechanisms. Cytotherapy 16, 17 – 32. Retrieved
from http://www.sciencedirect.com/science/article/pii/S1465324913006063
Rat Skin
Chaichalotornkul, S. (2014). Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat
premature skin aging model. Biochemical and Biophysical Research Communications 456, 92 – 97.
Retrieved from http://www.sciencedirect.com/science/article/pii/S0006291X1402052X
Rat Kidney Tissue
Chen, C., Chou, H., & Huang, L. (2014). Maternal nicotine exposure during gestation and lactation induces kidney
injury and fibrosis in rat offspring. Pediatric Research doi: 10.1038/pr.2014.148. Retrieved from
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Human Ligamentum Flavum Cells
Chen, M. H., Hu, C. K., Chen, P. R., Chen, Y. S., & ... (2014). Dose-dependent regulation of cell proliferation and
collagen degradation by estradiol on ligamentum flavum. BMC Musculosketal Disorders 15, 238. Retrieved
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Rat Achilles Tenocytes
Chen, M., Huang, Y., & Sun, J. (2014). Second messengers mediating the proliferation and collagen synthesis of
tenocytes induced by low-level laser irradiation. Lasers in Medical Science doi: 10.1007/s10103.014.1658.5.
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Mouse Lung
Chen, T., Nie, H., Gao, X., Yang, J., Pu, J., Chen, Z., … (2014). Epithelial–mesenchymal transition involved in
pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway.
Toxicology Letters 226, 150 – 162. Retrieved from
Human Skin Fibroblasts (CCD966SK)
Chen, Y., & Hwang, D. (2014). Evaluation of anti oxidant properties and biofunctions of polar, nonpolar, and watersoluble fractions extracted from gonad and body wall of the sea urchin Tripneustes. Fisheries Science doi:
10.1007/s12562-014-0808-9. Retrieved from http://link.springer.com/article/10.1007/s12562-014-0808-9
Normal Human Skin Fibroblast Cells (Detroit 551)
Chen, Y., Lee, S., Lin, Y., Chiang, S., & Lin, C. (2014). Effects of Danshensu and Salvianolic Acid B from Salvia
miltiorrhiza Bunge (Lamiaceae) on Cell Proliferation and Collagen and Melanin Production. Molecules 19,
2029 – 2041. Retrieved from http://www.mdpi.com/1420-3049/19/2/2029/htm
Synovial Fluid Mesenchymal Stem Cells in a Rabbit Model
Chen, Y. P., Chen, W. C., Wang, K. C., & Chen, C. H. (2014). Effectiveness of synovial fluid mesenchymal stem cells
embedded in alginate beads for treatment of steroid-induced avascular necrosis of the femoral head.
Journal of Orthopaedic Sci. 19, 657 – 666. Retrieved from
Wound Tissue
Chereddy, K., Her, C., & Comune, M. (2014). PLGA nanoparticles loaded with host defense peptide LL37 promote
wound healing. Journal of Controlled Release 194, 138 – 147. Retrieved from
Mouse Lung
Cheresh, P., & Morales-Nebreda, L. (2014). Asbestos-Induced Pulmonary Fibrosis is Augmented in 8-Oxoguanine DNA
Glycosylase (OGG1) Knockout mice. American Journal of Respir Cell Mol Biol. doi: 10.1165/rcmb.201400380c. Retrieved from http://www.atsjournals.org/doi/abs/10.1165/rcmb.2014-0038OC
Chiang, H., Chen, C., Lin, T., & Kuo, Y. (2014). N-phenethyl caffeamide and photodamage: Protecting skin by
inhibiting type I procollagen degradation and stimulating collagen synthesis. Food and Chemical Toxicology
72, 154 – 161. Retrieved from http://www.sciencedirect.com/science/article/pii/S0278691514003317
Mouse Osteoblastic Cell Line (MC3T3-E1)
Choi, E. M. (2014). Sunflower seed extract enhances the differentiation of osteoblastic MC3T3-E1 cells. Food and
Agricultural Immunology 25, 9 – 19. Retrieved from
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Lung Fibroblasts
Chrysanthopoulou, A. (2014). Neutrophil extracellular traps promote differentiation and function of fibroblasts. The
Journal of Pathology 233, 294 – 307. Retrieved from
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Mesenchymal Stem Cells
Chuah, Y., Kuddannaya, S., & Lee, M. (2015). The effects of poly (dimethylsiloxane) surface silanization on the
mesenchymal stem cell fate. Biomaterials Science doi: 10.1039/C4BM00268G. Retrieved from
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Adult Male Rat Cardiac Fibroblasts
Chung, C. C., Hsu, R. C., Kao, Y. H., Liou, J. P., Lu, Y. Y., & ... (2014). Androgen Attenuates Cardiac Fibroblasts
Activations through Modulations of Transforming growth factor-β and Angiotensin II Signaling. International
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Mouse Lung
Chung, E., Hudak, K., & Horton, J. (2014). Transforming Growth Factor Alpha is a Critical Mediator of Radiation
Lung Injury. Radiation Research 182, 350 – 362. Retrieved from
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Chung, S., Park, I., & Hong, S. (2014). Role of Caffeic Acid on Collagen Production in Nasal Polyp-Derived
Fibroblasts. Clinical Exp Otorhinolaryngol 7, 295 – 301. Retrieved from
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Mouse Lung
Conte, E., Lemmolo, M., Fagone, E., Gili, E., Fruciano, M., & ... (2014). Thymosin β4 reduces IL-17-producing cells
and IL-17 expression, and protects lungs from damage in bleomycin-treated mice. Immunobiology 219, 425
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Cui, Y., Osorio, J., Risquez, C., & Wang, H. (2014). Transforming Growth Factor-β1 Downregulates Vascular
Endothelial Growth Factor-D Expression in Human Lung Fibroblasts via the Jun NH2-Terminal Kinase
Signaling Pathway. Molecular Medicine 20, 120 – 134. Retrieved from
Horse Tendon
Dakin, S. G., Smith, R. K. W., Heinegård, D., & ... (2014). Proteomic Analysis of Tendon Extracellular Matrix
Reveals Disease Stage-specific Fragmentation and Differential Cleavage of COMP (Cartilage Oligomeric
Matrix Protein). Journal of Biological Chemistry 289, 4919 – 4927. Retrieved from
http://www.jbc.org/content/289/8/4919.short
Human Prostatic Epithelial Cells
Damodarasamy, M., & Vernon, R. (2014). Hyaluronan in aged collagen matrix increases prostate epithelial cell
proliferation. In Vitro Cellular & Dev. Biol. – Animal doi: 10.1007/s11626-014-9800-z. Retrieved from
http://link.springer.com/article/10.1007/s11626-014-9800-z
Rat Left Ventricle
Daryadel, A., & Bogdanova, A. (2014). Multikinase inhibitor sorafenib prevents pressure overload-induced left
ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway. Journal of Cardiothoracic
Surgery 9, 81. Retrieved from http://www.biomedcentral.com/content/pdf/1749-8090-9-81.pdf
Human Lung Extracts
Das, S., Kumar, M., & Negi, V. (2014). MicroRNA-326 Regulates Profibrotic Functions of Transforming Growth
Factor-β in Pulmonary Fibrosis. American Journal of Respiratory, Cell and Molecular Biology 50, 882 – 892.
Human Hepatic Stellate Cell Line (LX-2)
den Hartog, G. J. M., Qi, S., van Tilburg, J. H. O., & ... (2014). Superoxide anion radicals activate hepatic stellate
cells after entry through chloride channels: A new target in liver fibrosis. European Journal of
Pharmacology 724, 140 – 144. Retrieved from
Rat Cardiac Fibroblasts
Driesen, R. B., Nagaraju, C. K., & ... (2014). Reversible and irreversible differentiation of cardiac fibroblasts.
Cardiovascular Research 101, 411 – 422. Retrieved from
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Mouse Lung and Dendritic Cells
Dunand-Sauthier, I., Irla, M., Carnesecchi, S., & ... (2014). Repression of Arginase-2 Expression in Dendritic Cells by
MicroRNA-155 Is Critical for Promoting T Cell Proliferation. The Journal of Immunology 193, 1690 – 1700.
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Mouse Skeletal and Cardiac Muscle
Ermolova, N., Martinez, L., & Vetrone, S. (2014). Long-term administration of the TNF blocking drug Remicade
(cV1q) to mdx mice reduces skeletal and cardiac muscle fibrosis, but negatively impacts cardiac function.
Neuromuscular Disorders 24, 583 – 595. Retrieved from
Mouse Liver
Espíndola, M., & Frantz, F. (2014). Combined immunization using DNA-Sm14 and DNA-Hsp65 increases CD8+ memory
T cells, reduces chronic pathology and decreases egg viability during Schistosoma mansoni infection. BMC
Infectious Diseases 14, 263. Retrieved from http://www.biomedcentral.com/1471-2334/14/263
Basement Membrane Complex of Porcine Urinary Bladder
Faulk, D. M., Carruthers, C. A., Warner, H. J., Kramer, C. R., & ... (2014). The effect of detergents on the
basement membrane complex of a biologic scaffold material. Acta Biomaterialia 10, 183 – 193. Retrieved
from http://www.sciencedirect.com/science/article/pii/S1742706113004595
Mouse Colon
Fichtner-Feigl, S., Kesselring, R., Martin, M., & ... (2014). IL-13 Orchestrates Resolution of Chronic Intestinal
Inflammation via Phosphorylation of Glycogen Synthase Kinase-3β. The Journal of Immunology 192, 3969 –
3980. Retrieved from http://www.jimmunol.org/content/192/8/3969.short
Murine Lung
François, A., Gombault, A., & Villeret, B. (2014). B cell activating factor is central to bleomycin-and IL-17mediated experimental pulmonary fibrosis. Journal of Autoimmunity doi: 10.1016/j.jaut.2014.08.003.
Mouse Model of Urogenital Schistosomiasis
Fu, C., Odegaard, J., & Hsieh, M. (2014). Macrophages are required for host survival in experimental urogenital
schistosomiasis. The FASEB Journal doi: 10.1096/fj.14-259572. Retrieved from
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Rat, Skin and Lung
Gao, F., Fish, B. L., Szabo, A., Schock, A., & ... (2014). Enhanced survival from radiation pneumonitis by combined
irradiation to the skin. International Journal of Radiation Biology 90, 753 – 761. Retrieved from
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Rat Lung
Gazdhar, A., Grad, I., & Tamò, L. (2014). The secretome of induced pluripotent stem cells reduces lung fibrosis in
part by hepatocyte growth factor. Stem Cell Research & Therapy 5, 123. Retrieved from
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Osteoblasts and Osteoclasts
Ghag, A. K., Gough, J. E., & Downes, S. (2014). The osteoblast and osteoclast responses to phosphonic acid
containing poly (ε-caprolactone) electrospun scaffolds. Biomaterials Science 2, 233 – 241. Retrieved from
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Mouse Lung
Gharib, S. A., Johnston, L. K., Huizar, I., & ... (2014). MMP28 promotes macrophage polarization toward M2 cells
and augments pulmonary fibrosis. Journal of Leukocyte Biology 95, 9 – 18. Retrieved from
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Human and Porcine Lungs
Gilpin, S. E., Guyette, J. P., Gonzalez, G., Ren, X., & ... (2014). Perfusion decellularization of human and porcine
lungs: Bringing the matrix to clinical scale. The Journal of Heart and Lung Transplantation 33, 298 – 308.
Mouse Lung
Glista-Baker, E. E., Taylor, A. J., & ... (2014). Nickel Nanoparticles cause exaggerated lung and airway remodeling
in mice lacking the T-box transcription factor, TBX21 (T-bet). Particle and Fibre Toxicology 11, 7.
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Rat Aorta
Gu, Q., Wang, B., Zhang, X. F., Ma, Y. P., Liu, J. D., & ... (2014). Chronic aerobic exercise training attenuates
aortic stiffening and endothelial dysfunction through preserving aortic mitochondrial function in aged rats.
Experimental Gerontology 56, 37 – 44. Retrieved from
Rat Lung
Gustafsson, Å., Svensson‐Elfsmark, L., & ... (2014). Strain differences influence timing and magnitude of both acute
and late inflammatory reactions after intratracheal instillation of an alkylating agent in rats. Journal of
Applied Toxicology 34, 272 – 280. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/jat.2878/full
Porcine Aortic Valve Leaflets
Hammer, P. E., Pacak, C. A., Howe, R. D., & del Nido, P. J. (2014). Straightening of curved pattern of collagen
fibers under load controls aortic valve shape. Journal of Biomechanics 47, 341 – 346. Retrieved from
Mouse Lung
Hams, E., Armstrong, M. E., Barlow, J. L., & ... (2014). IL-25 and type 2 innate lymphoid cells induce pulmonary
fibrosis. Proceedings of the Natl Acad Sci. 111, 367 – 372. Retrieved from
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Primary Human Osteoblasts
Henstock, J. R., Ruktanonchai, U. R., Canham, L. T., & ... (2014). Porous silicon confers bioactivity to
polycaprolactone composites in vitro. Journal of Materials Science 25, 1087 – 1097. Retrieved from
Human Dermal Fibroblasts and Melanocytes
Ho, M., Koh, D., & Cho, M. (2014). The mixture of glycitin and TDB (3-(2, 4, 6-trimethoxyphenyl)-2, 3-dihydro-1Hbenzo[f]chromen-1-one) could ameliorate skin ageing by anti-wrinkle and anti-melanogenesis effects in
dermal fibroblasts and melanocytes. Journal of the Korean Society for Applied Biological Chemistry 57, 835
– 842. Retrieved from http://link.springer.com/article/10.1007/s13765-014-4304-9
Human Hepatic Stellate Cells
Hodge, A., Lourensz, D., Vaghjiani, V., Nguyen, H., & ... (2014). Soluble factors derived from human amniotic
epithelial cells suppress collagen production in human hepatic stellate cells. Cytotherapy 16, 1132 – 1144.
Parietal Epithelial Cells/Bowman’s Capsule
Holderied, A., Romoli, S., & Eberhard, J. (2014). Glomerular parietal epithelial cell activation induces collagen
secretion and thickening of Bowman’s capsule in diabetes. Laboratory Investigation doi:
10.1038/labinvest.2014.160. Retrieved from http://www.nature.com/articles/labinvest2014160
Mouse Intestine
Holzscheiter, M., Layland, L. E., & ... (2014). Lack of host gut microbiota alters immune responses and intestinal
granuloma formation during schistosomiasis. Clinical & Experimental Immunology 175, 246 – 257.
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Mouse Lung
Hong, G., Kim, N., Kim, T., & Ro, J. (2014). CD1d expressed in mast cell surface enhances IgE production in B cells
by up-regulating CD40L expression and mediator release in allergic asthma in mice. Cellular Signalling 26,
1105 – 1117. Retrieved from http://www.sciencedirect.com/science/article/pii/S0898656814000564
Mouse Lung
Hong, G. U., Kim, N. G., & Ro, J. Y. (2014). Expression of Airway Remodeling Proteins in Mast Cell Activated by
TGF-β Released in OVA-Induced Allergic Responses and Their Inhibition by Low-Dose Irradiation or 8-oxodG. Radiation Research 181, 425 – 438. Retrieved from
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Human Intestinal Subepithelial Myofibroblasts (ISEMFs)
Honzawa, Y., Nakase, H., Shiokawa, M., Yoshino, T., & ... (2014). Involvement of interleukin-17A-induced
expression of heat shock protein 47 in intestinal fibrosis in Crohn’s disease. Gut doi: 10.1136/gutjnl-2013305632. Retrieved from http://gut.bmj.com/content/early/2014/02/17/gutjnl-2013305632.full?g=widget_default
Primary Human Lung Myofibroblasts
Hostettler, K. (2014). Nintedanib (BIBF 1120) prevents TGF-β-induced pro-fibrotic effects in primary human lung
myofibroblasts derived from patients with idiopathic pulmonary fibrosis. European Respiratory Journal 44,
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Hostettler, K., & Zhong, J. (2014). Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with
idiopathic pulmonary fibrosis. Respiratory Research 15, 157. Retrieved from
Mouse Lung
House, J., Li, H., DeGraff, L., & Flake, G. (2014). Genetic variation in HTR4 and lung function: GWAS follow-up in
mouse. The FASEB Journal doi:10.1096/fj.14-253898. Retrieved from
Rat Lung
Huang, L., Chou, H., Lin, C., Yeh, T., & Chen, C. (2014). Maternal Nicotine Exposure Exacerbates Neonatal
Hyperoxia-Induced Lung Fibrosis in Rats. Neonatology 106, 94 – 101.
Polydimethylsiloxane-Modified Chitosan (PMSc) Amphiphilic Hydrogel
Huang, W. C., Liu, K. H., Liu, T. C., Liu, D. M., & Chen, S. Y. (2014). Synergistic hierarchical silicone-modified
polysaccharide hybrid as a soft scaffold to control cell adhesion and proliferation. Acta Biomaterialia 10,
Rabbit Ear and Fibroblasts
Huang, Y., Huang, C., Hu, C., & Wong, T. (2014). Portable ultraviolet light A1 light source to treat hypertrophic
scar. Dermatologica Sinica doi: 10.1016/j.dsi.2014.10.001. Retrieved from
Rabbit Subchondral Bone Mesenchymal Stem Cells
Huh, J., Koh, P., Seo, B., & Park, Y. (2014). Mangiferin Reduces the Inhibition of Chondrogenic Differentiation by
IL-1β in Mesenchymal Stem Cells from Subchondral Bone and Targets Multiple Aspects. International Journal
of Mol Sci 15, 16025 – 16042. Retrieved from http://www.mdpi.com/1422-0067/15/9/16025/htm
Mouse Lung
Inomata, M., Kamio, K., & Azuma, A. (2014). Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycininduced murine pulmonary fibrosis. Respiratory Research 15, 16. Retrieved from
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Rat Arteries and Veins
Jelinic, M., Leo, C. H., Uiterweer, E. D. P., Sandow, S. L., & ... (2014). Localization of relaxin receptors in arteries
and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo
serelaxin treatment. The FASEB Journal 28, 275 – 287. Retrieved from
Rat Kidney
Jiang, G. T., Chen, X., Li, D., An, H. X., & ... (2014). Ulinastatin attenuates renal interstitial inflammation and
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Dog Mitral Valve
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Murine Left Ventricle
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Murine Cardiac Tissue
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Murine Lung
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Fibroblasts
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Human Dental Pulp Cells
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Murine Aortic Endothelial Cells
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Murine Bladder
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partial bladder obstruction. Journal of Biomechanics, 46, 2752-2755.
Intervertebral disc Tissue
Chen,J., Lee,E.J., Jing,L., Christoforou,N., Leong,K.W. and Setton,L.A. (2013) Differentiation of Mouse Induced
Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells In Vitro. PloS one, 8, e75548.
Rabbit Bone Marrow Stromal Cells
Chen,K., Ng,K.S., Ravi,S., Goh,J.C. and Toh,S.L. (2013) In vitro generation of whole osteochondral constructs using
rabbit bone marrow stromal cells, employing a twochambered coculture well design. Journal of tissue
engineering and regenerative medicine, doi: 10.1002/term.1716.
Aortic Tissue
Cheng,S.L., Shao,J.S., Behrmann,A., Krchma,K. and Towler,D.A. (2013) Dkk1 and Msx2Wnt7b Signaling
Reciprocally Regulate the EndothelialMesenchymal Transition in Aortic Endothelial Cells. Arteriosclerosis,
thrombosis, and vascular biology, 33, 1679-1689.
Murine Dermal Wound
Chereddy,K.K., Coco,R., Memvanga,P.B., Ucakar,B., des Rieux,A., Vandermeulen,G. and Préat,V.+. (2013)
Combined effect of PLGA and curcumin on wound healing activity. Journal of Controlled Release, 171, 208215.
Human Skin Fibroblast Cell Cultures (Hs68)
Chiang,H.M., Chen,H.C., Chiu,H.H., Chen,C.W., Wang,S.M. and Wen,K.C. (2013) Neonauclea reticulata (Havil.) Merr
stimulates skin regeneration after UVB exposure via ROS scavenging and modulation of the
MAPK/MMPs/collagen pathway. Evidence-Based Complementary and Alternative Medicine Volume 2013,
Article ID 324864, 9 pages,2013, http://dx.doi.org/10.1155/2013.324864.
Rat Liver
Choi,J.H., Jin,S.W., Kim,H.G., Khanal,T., Hwang,Y.P., Lee,K.J., Choi,C.Y., Chung,Y.C., Lee,Y.C. and Jeong,H.G.
(2013) Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2mediated antioxidant enzymes. Food and Chemical Toxicology 56, 231 – 239.
Human Dermal Fibroblasts
Cho,S.Y., Seo,D.B., Kim,W.G. and Lee,S.J. (2013) Mild Mitochondrial Uncoupling Prevents Premature Senescence in
Human Dermal Fibroblasts. Journal of Investigative Dermatology, doi: 10.1038/jid.2013.352.
Rat Lung
Cho,Y.J., Yi,C.O., Jeon,B.T., Jeong,Y.Y., Kang,G.M., Lee,J.E., Roh,G.S. and Lee,J.D. (2013) Curcumin Attenuates
Radiation-Induced Inflammation and Fibrosis in Rat Lungs. The Korean Journal of Physiology &
Pharmacology, 17, 267-274.
Human Umbilical Cord Mesenchymal Stromal cells
Chon,B.H., Lee,E.J., Jing,L., Setton,L.A. and Chen,J. (2013) Human umbilical cord mesenchymal stromal cells
exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-3D culture system. Stem Cell
Res Ther, 4, 120.
Porcine Thoracic Aorta
Chow,M.J., Mondonedo,J.R., Johnson,V.M. and Zhang,Y. (2013) Progressive structural and biomechanical changes in
elastin degraded aorta. Biomechanics and Modeling in Mechanobiology, 12, 361 - 372.
Mouse Renal Tissue
Chung,H., Hollenberg,M.D. and Muruve,D.A. (2013) Proteinase-activated receptor-2 transactivation of EGF-and
TGFβ-receptor signaling pathways contributes to renal fibrosis. Journal of Biological Chemistry, doi:
10.1074/jbc.M113.492793.
Murine Lung
Citrin,D.E., Shankavaram,U., Horton,J.A., Shield,W., Zhao,S., Asano,H., White,A., Sowers,A., Thetford,A. and
Chung,E.J. (2013) Role of type II pneumocyte senescence in radiation-induced lung fibrosis. Journal of the
National Cancer Institute, 105, 1474-1484.
Human Lung Tissue and Fibroblast Cell Lines
Conte,E., Gili,E., Fruciano,M., Korfei,M., Fagone,E., Iemmolo,M., Furno,D.L., Giuffrida,R., Crimi,N. and
Guenther,A. (2013) PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast
cells: in vitro effects of its inhibition. Laboratory Investigation, 93, 566-576.
Murine Lung
Conte,E., Genovese,T., Gili,E., Esposito,E., Iemmolo,M., Fruciano,M., Fagone,E., Pistorio,M.P., Crimi,N. and
Cuzzocrea,S. (2013) Thymosin +¦4 protects C57BL/6 mice from bleomycininduced damage in the lung.
European journal of clinical investigation 43, 309 – 315.
Pulmonary Tissue
Cox,T.R., Bird,D., Baker,A.M., Barker,H.E., Ho,M.W., Lang,G. and Erler,J.T. (2013) LOX-mediated collagen
crosslinking is responsible for fibrosis-enhanced metastasis. Cancer research, 73, 1721-1732.
Autogenic Osteoblast- or Chondrocyte Induced Bone Marrow Stromal Cells
Da,H., Jia,S.J., Meng,G.L., Cheng,J.H., Zhou,W., Xiong,Z., Mu,Y.J. and Liu,J. (2013) The Impact of Compact Layer
in Biphasic Scaffold on Osteochondral Tissue Engineering. PloS one, 8, e54838.
Male Calf Wound
Das,J., Nath,L., Routray,P., Das,R.K., Behera,S.S. and Purohit,G.K. Targeting chronic Ulcerative wound at thigh
region in a bull calf by autologous stem cell therapy. E-planet 10, 12 – 16.
Das,J., Nath,I., Routray,P., Behera,S.S. and Purohit,G.K. (2013) Stem cell therapy for chronic ulcerative wound in a
dog. Indian Journal of Veterinary Surgery, 34, 67.
Das,J., Nath,I., Routray,P. and Das,R.K. (2013) Autologous Bone Marrow derived Mesenchymal Stem Cells (BM-MSCs)
therapy for treatment of Chronic Limb Wound in a Bull. Intas Polivet, 14, 61-66.
Murine Lung
Das,S., Kumar,M., Negi,V., Pattnaik,B., Prakash,Y.S., Agrawal,A. and Ghosh,B. (2013) MicroRNA-326 Regulates ProFibrotic Functions of Transforming Growth Factor-β in Pulmonary Fibrosis. American Journal of Respiratory
Cell and Molecular Biology, doi: 10.1165/rcmb.2013-01950c.
Murine Lung
Dhanda,D.S., Tyagi,P., Mirvish,S.S. and Kompella,U.B. (2013) Supercritical Fluid Technology Based Large Porous
Celecoxib-PLGA Microparticles Do Not Induce Pulmonary Fibrosis and Sustain Drug Delivery and Efficacy for
Several Weeks Following A Single Dose. Journal of Controlled Release 168, 239 – 250.
Human Colonic Epithelial Cells and Subepithelial Myofibroblasts
Drygiannakis,I., Valatas,V., Sfakianaki,O., Bourikas,L., Manousou,P., Kambas,K., Ritis,K., Kolios,G. and
Kouroumalis,E. (2013) Proinflammatory cytokines induce crosstalk between colonic epithelial cells and
subepithelial myofibroblasts: Implication in intestinal fibrosis. Journal of Crohn's and Colitis, 7, 286-300.
Human Wharton’s-Jelly Derived Mesenchymal Stromal Cells (WJ-MSCs)
Du,T., Zou,X., Cheng,J., Wu,S., Zhong,L., Ju,G., Zhu,J., Liu,G., Zhu,Y. and Xia,S. (2013) Human Wharton's jellyderived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte
growth factor synthesis in injured tubular epithelial cells. Stem cell research & therapy, 4, 59.
Rat Lung
Ermis,H., Parlakpinar,H., Gulbas,G., Vardi,N., Polat,A., Cetin,A., Kilic,T. and Aytemur,Z.A. (2013) Protective effect
of dexpanthenol on bleomycin-induced pulmonary fibrosis in rats. Naunyn-Schmiedeberg's archives of
pharmacology, 386, 1103-1110.
Basement Membrane Complex of Porcine Urinary Bladder
Faulk,D.M., Carruthers,C.A., Warner,H.J., Kramer,C.R., Reing,J.E., Zhang,L., D’Amore,A. and Badylak,S.F. (2014)
The effect of detergents on the basement membrane complex of a biologic scaffold material. Acta
biomaterialia, 10, 183-193.
Porcine Papillary Dermis and Epidermis
Fernandes,J.R., Samayoa,J.C., Broelsch,G.F., McCormack,M.C., Nicholls,A.M., Randolph,M.A., Mihm,M.C. and usten
Jr,W.G. (2013) Micro-Mechanical Fractional Skin Rejuvenation. Plastic and reconstructive surgery, 131,
216-223.
Murine Lung
Ferreira,T.P., de Arantes,A.C., do Nascimento,C.V.M., Olsen,P.C., Trentin,P.c.G., Rocco,P.R., Hogaboam,C.M.,
Puri,R.K., Martins,M.A.l. and Silva,P.c.M.R. (2013) IL-13 Immunotoxin Accelerates Resolution of Lung
Pathological Changes Triggered by Silica Particles in Mice. The Journal of Immunology, 191, 5220-5229.
Human Umbilical Cord Warton’s Jelly stem Cells
Fong,C., Tam,K., Cheyyatraivendran,S., Gan,S., Gauthaman,K., Armugam,A., Jeyaseelan,K., Choolani,M., Biswas,A.
and Bongso,A. (2013) Human umbilical cord Wharton's jelly stem cells and its conditioned medium enhance
healing of excisional and diabetic wounds. Journal of cellular biochemistry, doi: 10.1002/jcb.24661.
Ford,B.M., Eid,A.A., Gooz,M., Barnes,J.L., Gorin,Y.C. and Abboud,H.E. (2013) ADAM17 mediates Nox4 expression
and NADPH oxidase activity in the kidney cortex of OVE26 mice. American Journal of Physiology-Renal
Physiology 305, F323 – 32.
Co-Culture of Human Blood B Cells and Dermal Fibroblasts
François,A., Chatelus,E., Wachsmann,D., Sibilia,J., Bahram,S., Alsaleh,G. and Gottenberg,J.E. (2013) B
lymphocytes and B cell activating factor promote collagen and profibrotic markers expression by dermal
fibroblasts in systemic sclerosis. Arthritis research & therapy, 15, R168.
Gabasa,M., Royo,D., Molina-Molina,M., Roca-Ferrer,J., Pujols,L., Picado,C., Xaubet,A. and Pereda,J. (2013) Lung
Myofibroblasts Are Characterized by Down-Regulated Cyclooxygenase-2 and Its Main Metabolite,
Prostaglandin E2. PloS one, 8, e65445.
Rat Lung
Gao,F., Fish,B.L., Moulder,J.E., Jacobs,E.R. and Medhora,M. (2013) Enalapril Mitigates Radiation-Induced
Pneumonitis and Pulmonary Fibrosis if Started 35 Days after Whole-Thorax Irradiation. Radiation research
180, 546 – 552.
Rat Lung
Gao,F., Narayanan,J., Joneikis,C., Fish,B.L., Szabo,A., Moulder,J.E., Molthen,R.C., Jacobs,E.R., Rao,R.N. and
Medhora,M. (2013) Enalapril Mitigates Focal Alveolar Lesions, A Histological Marker of Late Pulmonary Injury
by Radiation to the Lung. Radiation research, 179, 465-474.
Murine Lung
Garcia,O., Carraro,G., Turcatel,G., Hall,M., Sedrakyan,S., Roche,T., Buckley,S., Driscoll,B., Perin,L. and
Warburton,D. (2013) Amniotic Fluid Stem Cells Inhibit the Progression of Bleomycin-Induced Pulmonary
Fibrosis via CCL2 Modulation in Bronchoalveolar Lavage. PloS one, 8, e71679.
Murine Lung
Garibaldi,B.T., D'Alessio,F.R., Mock,J.R., Files,D.C., Chau,E., Eto,Y., Drummond,M.B., Aggarwal,N.R., Sidhaye,V.
and King,L.S. (2013) Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte
recruitment. American Journal of Respiratory Cell and Molecular Biology, 48, 35-43.
Osteoblasts and Osteoclasts
Ghag,A.K., Gough,J.E. and Downes,S. (2014) The osteoblast and osteoclast responses to phosphonic acid containing
poly (+Á-caprolactone) electrospun scaffolds. Biomaterials Science doi: 10.1039/C3BM60188A.
Murine Lung
Gharib,S.A., Johnston,L.K., Huizar,I., Birkland,T.P., Hanson,J., Wang,Y., Parks,W.C. and Manicone,A.M. (2013)
MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. Journal of
leukocyte biology, doi: 10.1189/ jlb-1112587.
Human and Porcine Lung
Gilpin,S.E., Guyette,J.P., Gonzalez,G., Ren,X., Asara,J.M., Mathisen,D.J., Vacanti,J.P. and Ott,H.C. (2013)
Perfusion Decellularization of Human and Porcine Lungs: Bringing the Matrix to Clinical Scale. The Journal
of Heart and Lung Transplantation, http://dx.doi.org/10.1016/j.healun.2013.10.030.
Murine Embryonic Stem Cells (CRL-1934)
Goh,S.K., Olsen,P. and Banerjee,I. (2013) Extracellular Matrix Aggregates from Differentiating Embryoid Bodies as a
Scaffold to Support ESC Proliferation and Differentiation. PloS one, 8, e61856.
Rat Dermal Wound
Gong,C., Wu,Q., Wang,Y., Zhang,D., Luo,F., Zhao,X., Wei,Y. and Qian,Z. (2013) A biodegradable hydrogel system
containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 34, 6377 – 6387.
Murine Lung
Gregory,L.G., Jones,C.P., Mathie,S.A., Pegorier,S. and Lloyd,C.M. (2013) Endothelin1 directs airway remodeling
and hyperreactivity in a murine asthma model. Allergy 68, 1579 – 1588.
Murine Lung Tissue
Gregory,L.G., Jones,C.P., Walker,S.A., Sawant,D., Gowers,K.H., Campbell,G.A., McKenzie,A.N. and Lloyd,C.M.
(2013) IL-25 drives remodelling in allergic airways disease induced by house dust mite. Thorax, 68, 82-90.
Murine Colon
Guan,Q., Burtnick,H.A., Qing,G., Weiss,C.R., Ma,A.G., Ma,Y., Warrington,R.J. and Peng,Z. (2013) Employing an IL23 p19 vaccine to block IL-23 ameliorates chronic murine colitis. Immunotherapy, 5, 1313-1322.
Rat Skeletal Muscle
Gupta,A.R., Dey,S., Swarup,D., Sainid,M. and Izatnagar,I. (2013) Effects of excessive fluoride ingestion on collagen
protein and expression of type 1 collagen gene in skeletal muscles of rats. Fluoride 46, 149 – 155.
Rat Lung
Gustafsson,A., SvenssonElfsmark,L., Lorentzen,J.C. and Bucht,A. (2013) Strain differences influence timing and
magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating
agent in rats. Journal of Applied Toxicology doi: 10.1002/jat2878.
Engineered Fibrocartilage
Hadidi,P. and Athanasiou,K.A. (2013) Enhancing the mechanical properties of engineered tissue through matrix
remodeling via the signaling phospholipid lysophosphatidic acid. Biochemical and Biophysical Research
Communications 433, 133 – 138.
Rat Myocardial Tissue
Hamdani,N., Franssen,C., Lourenço,A., Falão-Pires,I., Fontoura,D., Leite,S., Plettig,L., López,B.a.,
Ottenheijm,C.A. and Becher,P.M. (2013) Myocardial Titin Hypophosphorylation Importantly Contributes to
Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model. Circulation: Heart Failure, 6,
1239-1249.
Hammer,P.E., Pacak,C.A., Howe,R.D. and del Nido,P.J. (2013) Straightening of curved pattern of collagen fibers
under load controls aortic valve shape. Journal of Biomechanics
http://dx.doi.org/10.1016/j.jbiomech.2013.11.032.
Porcine Aortic Valves
Hammer,P.E., Pacak,C.A., Howe,R.D. and Pedro,J. (2013) Collagen Bundle Orientation Explains Aortic Valve
Leaflet Coaptation. In Functional Imaging and Modeling of the Heart, pp. 409-415. Springer.
Murine Lung
Hartopo,A.B., Emoto,N., Vignon-Zellweger,N., Suzuki,Y., Yagi,K., Nakayama,K. and Hirata,K.i. (2013) EndothelinConverting Enzyme1 Gene Ablation Attenuates Pulmonary Fibrosis via CGRP-cAMP/EPAC1 Pathway.
American Journal of Respiratory Cell and Molecular Biology, 48, 465-476.
Primary Human Osteoblast Cell Line
Hasan,M.S., Ahmed,I., Parsons,A.J., Walker,G.S. and Scotchford,C.A. (2013) The influence of coupling agents on
mechanical property retention and long-term cytocompatibility of phosphate glass fibre reinforced PLA
composites. Journal of the mechanical behavior of biomedical materials, 28, 1-14.
Human Osteosarcoma (MG63) and Primary Human Osteoblast Cell Lines
Hasan,S., Ahmed,I., Parsons,A.J., Walker,G.S. and Scotchford,C.A. (2013) Cytocompatibility assessment of chemical
surface treatments for phosphate glass to improve adhesion between glass and polyester. Journal of
Biomedical Materials Research Part A, 101, 3301-3310.
Murine Lung
Hasan,S.A., Eksteen,B., Reid,D., Paine,H.V., Alansary,A., Johannson,K., Gwozd,C., Goring,K.A., Vo,T. and Proud,D.
(2013) Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis. Journal of
Allergy and Clinical Immunology 131, 1663 – 1673.e5.
Microporous Elastic Patch on Rat left Ventricular Lesions
Hashizume,R., Hong,Y., Takanari,K., Fujimoto,K.L., Tobita,K. and Wagner,W.R. (2013) The effect of polymer
degradation time on functional outcomes of temporary elastic patch support in ischemic cardiomyopathy.
Biomaterials 34, 7353 – 7363.
Murine Lung
Henderson Jr,W.R., Ye,X., Lai,Y., Ni,Z., Bollinger,J.G., Tien,Y.T., Chi,E.Y. and Gelb,M.H. (2013) Key Role of Group
V Secreted Phospholipase A2 in Th2 Cytokine and Dendritic Cell-Driven Airway Hyperresponsiveness and
Remodeling. PloS one, 8, e56172.
Human Bone Marrow-Derived Mesenchymal Stem Cells
Hegner,B., Schaub,T., Catar,R., Kusch,A., Wagner,P., Essin,K., Lange,C., Riemekasten,G., Dragun,D. and
Berlin,C.U. Deregulated vascular smooth muscle cell differentiation with increased propensity towards
myofibroblastic phenoconversion of mesenchymal stem cells from patients with systemic sclerosis.
essinek.com/pdfs/Hegner_B_submitted_2013.pdf
Murine Lung Tissue
Hirata,H., Arima,M., Fukushima,Y., Sugiyama,K., Tokuhisa,T. and Fukuda,T. (2013) Leukotriene C4 aggravates
bleomycininduced pulmonary fibrosis in mice. Respirology, 18, 674-681.
Murine Bone Marrow-Derived Mast Cells
Hong,G.U., Park,B.S., Park,J.W., Kim,S.Y. and Ro,J.Y. (2013) IgE production in CD40/CD40L cross-talk of B and
mast cells and mediator release via TGase 2 in mouse allergic asthma. Cellular Signalling 25, 1514 – 1525.
Murine Skin after Infusion with Bone Marrow-Derived Mesenchymal Stem Cells
Horton,J.A., Hudak,K.E., Chung,E.J., White,A.O., Scroggins,B.T., Burkeen,J.F. and Citrin,D.E. (2013) Mesenchymal
stem cells inhibit cutaneous radiationinduced fibrosis by suppressing chronic inflammation. Stem Cells,
31, 2231-2241.
Murine Hind Limb
Horton,J., Li,F., Chung,E.J., Hudak,K., White,A., Krausz,K., Gonzalez,F. and Citrin,D. (2013) Quercetin Inhibits
Radiation-Induced Skin Fibrosis. Radiation Research, http://dx.doi.org/10.1667/RR3237.1.
Rabbit Medial Collateral Ligament
Hsu,W., Peng,K., Lai,L., Hung,C. and Chang,P. (2013) Cellular senescence occurring in the rabbit medial collateral
ligament during healing. Journal of Orthopaedic Research, 31, 81-90.
Murine Lung
Huang,J., Li,Z., Yao,X., Li,Y., Reng,X., Li,J., Wang,W., Gao,J., Wang,C. and Tankersley,C.G. (2013) Altered
Th1/Th2 commitment contributes to lung senescence in CXCR3-deficient mice. Experimental Gerontology
48, 717 – 726.
Human Murine Lung
Huang,L.S., Berdyshev,E., Mathew,B., Fu,P., Gorshkova,I.A., He,D., Ma,W., Noth,I., Ma,S.F. and Pendyala,S. (2013)
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. The FASEB Journal, 27,
1749-1760.
Murine Lung
Huang,L.S., Fu,P., Patel,P., Harijith,A., Sun,T., Zhao,Y., Garcia,J.G., Chun,J. and Natarajan,V. (2013)
Lysophosphatidic Acid Receptor 2 Deficiency Confers Protection Against Bleomycin-Induced Lung Injury and
Fibrosis in Mice. American journal of respiratory cell and molecular biology 49, 912 – 922.
Rabbit Osteoarthritis Model
Huh,J.E., Park,Y.C., Seo,B.K., Lee,J.D., Baek,Y.H., Choi,D.Y. and Park,D.S. (2013) Cartilage Protective and
Chondrogenic Capacity of WIN-34B, a New Herbal Agent, in the Collagenase-Induced Osteoarthritis Rabbit
Model and in Progenitor Cells from Subchondral Bone. Evidence-Based Complementary and Alternative
Medicine, http://dx.doi.org/10.1155/2013/527561.
Murine Skin
Huu,D.L., Matsushita,T., Jin,G., Hamaguchi,Y., Hasegawa,M., Takehara,K. and Fujimoto,M. (2013) FTY720
Ameliorates Murine Sclerodermatous Chronic GraftÇÉVersusÇÉHost Disease by Promoting Expansion of
Splenic Regulatory Cells and Inhibiting Immune Cell Infiltration Into Skin. Arthritis & Rheumatism, 65, 16241635.
Murine Aortic Root Lesions
Ishibashi,M., Sayers,S., Armiento,D., Tall,A.R. and Welch,C.L. (2013) TLR3 deficiency protects against collagen
degradation and medial destruction in murine atherosclerotic plaques. Atherosclerosis 229, 52 – 61.
Polyvinyl Alcohol Sponge from Tail Wound of a Mouse
Iwamoto,S., Lin,X., Ramirez,R., Carson,P., Fiore,D., Goodrich,J., Yufit,T. and Falanga,V. (2013) Bone Marrow Cell
Mobilization by the Systemic Use of Granulocyte Colony-Stimulating Factor (GCSF) Improves Wound Bed
Preparation. The International Journal of Lower Extremity Wounds, doi: 10.1177/1534734613513401.
Rat Abdominal Aorta, Mesenteric and Femoral Arteries.
Jelinic,M., Leo,C.H., Uiterweer,E.D.P., Sandow,S.L., Gooi,J.H., Wlodek,M.E., Conrad,K.P., Parkington,H., Tare,M.
and Parry,L.J. (2013) Localization of relaxin receptors in arteries and veins, and region-specific increases in
compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment. The FASEB Journal, doi:
10.1096/fj.13-233429.
Monkey Selected Chondrogenic Clonal Mesenchymal Stem Cells
Jiang,L., Ma,A., Song,L., Hu,Y., Dun,H., Daloze,P., Yu,Y., Jiang,J., Zafarullah,M. and Chen,H. (2013) Cartilage
regeneration by selected chondrogenic clonal mesenchymal stem cells in the collagenaseinduced monkey
osteoarthritis model. Journal of tissue engineering and regenerative medicine, doi: 10.1002/term.1676.
Murine Lung
Jonasson,S., Wigenstam,E., Koch,B. and Bucht,A. (2013) Early treatment of chlorine-induced airway
hyperresponsiveness and inflammation with corticosteroids. Toxicology and applied pharmacology 271, 168
– 174.
Sheep Liver Tissue
Kajbafzadeh,A.M., Javan-Farazmand,N., Monajemzadeh,M. and Baghayee,A. (2013) Determining the Optimal
Decellularization and Sterilization Protocol for Preparing a Tissue Scaffold of a Human-Sized Liver Tissue.
Tissue Engineering Part C: Methods 19, 642 – 651.
Kaji,K., Yoshiji,H., Ikenaka,Y., Noguchi,R., Aihara,Y., Douhara,A., Moriya,K., Kawaratani,H., Shirai,Y. and Yoshii,J.
(2013) Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic
stellate cell in rats. Journal of Gastroenterology, doi: 10.1007/s00535-013-0783-4.
Nasal Polyp Derived Fibroblasts
Kang,J.S., Park,I., Cho,J., Hong,S., Kim,T.H., Lee,S.H. and Lee,H. (2013) Epigallocatechin3Gallate Inhibits
Collagen Production of Nasal PolypDerived Fibroblasts. Phytotherapy Research, doi: 10.1002/ptr.4971.
Myofibroblast Cells
Kang,Y., Choi,Y., Yun,C., Park,J., Suk,K., Kim,H., Park,M., Lee,B., Lee,H. and Moon,S. (2013) Downregulation of
collagen synthesis and matrix metalloproteinase expression in myofibroblasts from dupuytren nodule using
adenovirusmediated relaxin gene therapy. Journal of Orthopaedic Research, doi: 10.1002/jor.22535.
Murine Skin Tissue
Kanno,Y., Kawashita,E., Kokado,A., Okada,K., Ueshima,S., Matsuo,O. and Matsuno,H. (2013) Alpha2antiplasmin
regulates the development of dermal fibrosis in mice by prostaglandin F2+¦ synthesis through adipose
triglyceride lipase/calciumindependent phospholipase A2. Arthritis & Rheumatism, 65, 492-502.
Murine Lung
Kao,S.T. (2013) The Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang Suppresses Th2 Responses and
Increases IFNγ in Dermatophagoides pteronyssinus Induced Chronic Asthmatic Mice. Evidence-Based
Complementary and Alternative Medicine, http://dx.doi.org/10.1155/2013/984121.
Neonatal Rat Cardiac Fibroblast Cells and Cardiomyocytes
Kharaziha,M., Nikkhah,M., Shin,S.R., Annabi,N., Masoumi,N., Gaharwar,A.K., Camci-Unal,G. and Khademhosseini,A.
(2013) PGS: Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering
cardiac tissues. Biomaterials 34, 6355 – 6366.
Murine Liver, Human Hepatic Stellate Cells LX-2 and Rat Primary Hepatic Stellate Cells
Kim,J.H., Jeong,Y.J., Hong,J.M., Kim,H.R., Kang,J.S., Lee,W.J. and Hwang,Y.i. (2014) Chronic vitamin C
insufficiency aggravated thioacetamide-induced liver fibrosis in gulo-knockout mice. Free Radical Biology
and Medicine, 67, 81-90.
Fibroblasts and Murine Models of Dermal Fibrosis
Krämer,M., Dees,C., Huang,J., Schlottmann,I., Palumbo-Zerr,K., Zerr,P., Gelse,K., Beyer,C., Distler,A. and
Marquez,V.E. (2013) Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.
Annals of the Rheumatic Diseases, 72, 614-620.
Rat HSC and Lx-2 Cells and Rat Liver Tissue
Kubo,N., Saito,R., Hamano,K., Nagasawa,M., Aoki,F., Takei,I., Umezawa,K., Kuwano,H. and Kojima,I. (2013)
Conophylline suppresses hepatic stellate cells and attenuates thioacetamideinduced liver fibrosis in rats.
Liver International doi: 10.1111/liv.12328.
Umbilical Cord Blood Derived Mesenchymal Stem Cells
Kumar Mekala,N., Raju Baadhe,R., Rao Parcha,S. and Devi,Y. (2013) Enhanced Proliferation and Osteogenic
Differentiation of Human Umbilical Cord Blood Stem Cells by L-Ascorbic Acid, In Vitro. Current Stem Cell
Research & Therapy, 8, 156-162.
Bovine Intervertebral Disc Cells
Kwon,Y.J., Lee,J.W., Moon,E.J., Chung,Y.G., Kim,O.S. and Kim,H.J. (2013) Anabolic Effects of Peniel 2000, a
Peptide That Regulates TGF-β1 Signaling on Intervertebral Disc Degeneration. Spine, 38, E49-E58.
Kyllönen,L., Haimi,S., Säkkinen,J., Kuokkanen,H., Mannerström,B., Sándor,G.K. and Miettinen,S. (2013)
Exogenously added BMP-6, BMP-7 and VEGF may not enhance the osteogenic differentiation of human
adipose stem cells. Growth Factors, 31, 141-153.
Porcine Myocardium
Ladage,D., Yaniz-Galende,E., Rapti,K., Ishikawa,K., Tilemann,L., Shapiro,S., Takewa,Y., Muller-Ehmsen,J.,
Schwarz,M. and Garcia,M.J. (2013) Stimulating Myocardial Regeneration with Periostin Peptide in Large
Mammals Improves Function Post-Myocardial Infarction but Increases Myocardial Fibrosis. PloS one, 8,
e59656.
Murine Skin
Le Huu,D., Matsushita,T., Jin,G., Hamaguchi,Y., Hasegawa,M., Takehara,K. and Fujimoto,M. (2013) FTY720
ameliorates murine SclcGVHD by promoting expansion of splenic regulatory cells and inhibiting immune
cell infiltration into skin. Arthritis & Rheumatism, doi: 10.1002/art.37933.
Murine Lung
Lee,E.h., Lee,E.j., Kim,H.j., Jang,A.s., Koh,E.s., Uh,S.t., Kim,Y.h., Park,S.w. and Park,C.s. (2013) Overexpression
of Apolipoprotein A1 in the Lung Abrogates Fibrosis in Experimental Silicosis. PloS one, 8, e55827.
Nasal Mucosae
Lee,H.M. (2013) Tissue Remodeling in Rhinosinusitis. Korean Journal of Otorhinolaryngology-Head and Neck
Surgery, 56, 327-331.
Nasal Polyp-Derived Fibroblasts
Lee,H.M. and Hong,S.M. (2013) Epigenetic Regulation of Myofibroblast Differentiation and Extracellular Matrix
Production in Nasal Polyp-Derived Fibroblasts. Journal of Allergy and Clinical Immunology, 131, AB329.
Rabbit Articular Chondrocytes
Lee,S.Y., Wee,A.S., Lim,C.K., Abbas,A.A., Selvaratnam,L., Merican,A.M., Ahmad,T.S. and Kamarul,T. (2013)
Supermacroporous poly (vinyl alcohol)-carboxylmethyl chitosan-poly (ethylene glycol) scaffold: an in vitro
and in vivo pre-assessments for cartilage tissue engineering. Journal of Materials Science: Materials in
Medicine, 24, 1561 – 1570.
Murine Inferior Vena Cava
Lee,Y.U., Naito,Y., Kurobe,H., Breuer,C.K. and Humphrey,J.D. (2013) Biaxial mechanical properties of the inferior
vena cava in C57BL/6 and CB-17 SCID/bg mice. Journal of Biomechanics, 46, 2277-2282.
Biomacromolecule Blend of Atelocollagen, Hyaluronan and Native Gellan.
Lefter,C.M., Maier,S.S., Maier,V., Popa,M. and Desbrieres,J. (2013) Engineering preliminaries to obtain reproducible
mixtures of atelocollagen and polysaccharides. Materials Science and Engineering: C 33, 2323 – 2331.
Murine Lung
Le Saux,C.J., Davy,P., Brampton,C., Ahuja,S.S., Fauce,S., Shivshankar,P., Nguyen,H., Ramaseshan,M., Tressler,R.
and Pirot,Z. (2013) A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic
Pulmonary Fibrosis. PloS one, 8, e58423.
Murine Colon, Terminal Ileum, Lung and Liver tissue
Leung,G., Wang,A., Fernando,M., Phan,V.C. and McKay,D.M. (2013) Bone marrow-derived alternatively activated
macrophages reduce colitis without promoting fibrosis: participation of IL-10. American Journal of
Physiology-Gastrointestinal and Liver Physiology, 304, G781-G792.
MG63 Cells Human Osteosarcoma Cell Line
Li,J., Wei,L., Sun,J. and Guan,G. (2013) Effect of ionic products of dicalcium silicate coating on osteoblast
differentiation and collagen production via TGF-β1 pathway. Journal of Biomaterials Applications, 27, 595604.
Renal Tissue and Fibroblasts
Li,L., Shen,Y., Ding,Y., Liu,Y., Su,D. and Liang,X. (2013) Hrd1 participates in the regulation of collagen I synthesis
in renal fibrosis. Molecular and cellular biochemistry, doi: 10.1007/s11010-013-1843-2.
Human Embryonic Stem Cells
Li,M., Li,X., Meikle,M.C., Islam,I. and Cao,T. (2013) Short periods of cyclic mechanical strain enhance triplesupplement directed osteogenesis and bone nodule formation by human embryonic stem cells in vitro.
Tissue Engineering Part A 19, 2130 – 2137.
L929 Fibroblast Cells, Murine Fibrosarcoma Cell Line
Lin,H.Y., Peng,C.W. and Wu,W.W. (2013) Fibrous hydrogel scaffolds with cells embedded in the fibers as a potential
tissue scaffold for skin repair. Journal of Materials Science: Materials in Medicine, doi: 10.1007/s10856-0135065-4.
Pulmonary Tissue
Li,R., Wang,X., Ji,Z., Sun,B., Zhang,H., Chang,C.H., Lin,S., Meng,H., Liao,Y.P. and Wang,M. (2013) The Surface
Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine
Pulmonary Toxicity. ACS Nano 7, 2352 – 2368.
Osteoblasts
Lin,H.Y. and Chen,J.H. (2013) Osteoblast Differentiation and Phenotype Expressions on Chitosan-coated Ti-6Al-4V.
Carbohydrate Polymers 97, 618 – 626.
Murine Fibroblast Cells (L929)
Lin,H.Y., Chen,H.H., Chang,S.H. and Ni,T.S. (2013) Pectin-chitosan-PVA nanofibrous scaffold made by
electrospinning and its potential use as a skin tissue scaffold. Journal of Biomaterials Science, Polymer
Edition, 24, 470-484.
Murine Decellularised Adipose Tissue
Lu,Q., Li,M., Zou,Y. and Cao,T. (2013) Delivery of basic fibroblast growth factors from heparinized decellularized
adipose tissue stimulates potent de novo adipogenesis. Journal of Controlled Release, doi:
10.1016/j.jconrel.2013.11.007.
Murine Lung
Luzina,I.G., Kopach,P., Lockatell,V., Kang,P.H., Nagarsekar,A., Burke,A.P., Hasday,J.D., Todd,N.W. and
Atamas,S.P. (2013) Interleukin-33 Potentiates Bleomycin-induced Lung Injury. American Journal of
Respiratory Cell and Molecular Biology 49, 999 – 1008.
Mesenchymal Stem Cell-Loaded Monkey Acellular Dermal Matrix
Ma,A., Jiang,L., Song,L., Hu,Y., Dun,H., Daloze,P., Yu,Y., Jiang,J., Zafarullah,M. and Chen,H. (2013)
Reconstruction of cartilage with clonal mesenchymal stem cell-acellular dermal matrix in cartilage defect
model in nonhuman primates. International immunopharmacology 16, 399 – 408.
Murine Lung
Ma,Y., Halayko,A.J., Basu,S., Guan,Q., Weiss,C.R., Ma,A.G., HayGlass,K.T., Becker,A.B., Warrington,R.J. and
Peng,Z. (2013) Sustained Suppression of IL-13 by a Vaccine Attenuates Airway Inflammation and Remodeling
in Mice. American Journal of Respiratory Cell and Molecular Biology, 48, 540-549.
Co-Cultures of Meniscus Cells and Articular Chondrocytes
MacBarb,R.F., Chen,A.L., Hu,J.C. and Athanasiou,K.A. (2013) Engineering functional anisotropy in fibrocartilage
neotissues. Biomaterials 34, 9980-9989.
Murine Lung
Makino,H., Aono,Y., Azuma,M., Kishi,M., Yokota,Y., Kinoshita,K., Takezaki,A., Kishi,J., Kawano,H. and Ogawa,H.
(2013) Antifibrotic effects of CXCR4 antagonist in bleomycin-induced pulmonary fibrosis in mice. The
Journal of Medical Investigation, 60, 127 – 137.
Engineered Neo Cartilage
Makris,E.A., MacBarb,R.F., Responte,D.J., Hu,J.C. and Athanasiou,K.A. (2013) A copper sulfate and hydroxylysine
treatment regimen for enhancing collagen cross-linking and biomechanical properties in engineered
neocartilage. The FASEB Journal, 27, 2421-2430.
Human Vascular Smooth Muscle Cells, Endothelial Cells and Bone Marrow-Derived Mesenchymal Stem Cells
Martinez,C., Henao,A., Rodriguez,J.E., Padgett,K.R. and Ramaswamy,S. (2013) Monitoring steady flow effects on
cell distribution in engineered valve tissues by magnetic resonance imaging. Molecular Imaging, 12, 1 - 13.
Martinez,C., Rath,S., Van Gulden,S., Pelaez,D., Alfonso,A., Fernandez,N., Kos,L., Cheung,H. and Ramaswamy,S.
(2013) Periodontal Ligament Cells Cultured under Steady Flow Environments Demonstrate Potential for Use
in Heart Valve Tissue Engineering. Tissue Engineering 19, 458 – 466.
Murine Skin and Lung
Marut,W., Jamier,V., Kavian,N., Servettaz,A.l., Winyard,P.G., Eggleton,P., Anwar,A., Nicco,C., Jacob,C. and
Chéreau,C. (2013) The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced Systemic
sclerosis in the mouse. Arthritis research & therapy, 15, R167.
Murine Skin and Lung Tissue
Marut,W., Kavian,N., Servettaz,A.l., HuaHuy,T., Nicco,C., Chóreau,C., Weill,B., DinhXuan,A.T. and
Batteux,F.d.r. (2013) Amelioration of Systemic Fibrosis in Mice by Angiotensin II Receptor Blockade.
Arthritis & Rheumatism, 65, 1367-1377.
Microfabricated Scaffolds Cultivated with Fibroblasts
Masoumi,N., Jean,A.l., Zugates,J.T., Johnson,K.L. and Engelmayr,G.C. (2013) Laser microfabricated poly (glycerol
sebacate) scaffolds for heart valve tissue engineering. Journal of Biomedical Materials Research Part A,
101, 104-114.
Porcine Aortic and Pulmonary Valvular Interstitial Cells
Masoumi,N., Johnson,K.L., Howell,M.C. and Engelmayr Jr,G.C. (2013) Valvular interstitial cell seeded poly (glycerol
sebacate) scaffolds: Toward a biomimetic in vitro model for heart valve tissue engineering. Acta
Biomaterialia 9, 5974 – 5988.
Rat Skin Fibroblasts
Masoumi,N., Jean,A.l., Zugates,J.T., Johnson,K.L. and Engelmayr,G.C. (2013) Laser microfabricated poly (glycerol
sebacate) scaffolds for heart valve tissue engineering. Journal of Biomedical Materials Research Part A,
101, 104-114.
Dermal Fibroblasts and Murine Skin
Maurer,B., Distler,A., Suliman,Y.A., Gay,R.E., Michel,B.A., Gay,S., Distler,J.H. and Distler,O. (2013) Vascular
endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis.
Annals of the rheumatic diseases, doi: 10.1136/annrheumdis-2013-203535.
Rat Lung
Miranda,L.F., Rodrigues,C.O., Ramachandran,S., Torres,E., Huang,J., Klim,J., Hehre,D., McNiece,I., Hare,J.M. and
Suguihara,C.Y. (2013) Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced
lung injury. Pediatric research 74, 682 – 688.
Porcine Pancreas
Mirmalek-Sani,S.H., Orlando,G., McQuilling,J., Pareta,R., Mack,D., Salvatori,M., Farney,A.C., Stratta,R.J., Atala,A.
and Opara,E.C. (2013) Porcine pancreas extracellular matrix as a platform for endocrine pancreas
bioengineering. Biomaterials 34, 5488 – 5495.
Murine Lung
Miyamoto,K., Tasaka,S., Nakano,Y., Shinoda,H., Kamata,H., Yamasawa,W., Ishii,M., Hasegawa,N. and Betsuyaku,T.
(2013) Differential Mechanisms of the Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonists
on Bleomycin-Induced Lung Fibrosis. Oopen Journal of Respiratory Diseases 3, 31 – 38.
Murine Lung
Mizutani,N., Nabe,T. and Yoshino,S. (2013) InterleukinÇÉ33 and alveolar macrophages contribute to the
mechanisms underlying the exacerbation of IgEmediated airway inflammation and remodelling in mice.
Immunology, 139, 205-218.
Undetermined Model
Moeinzadeh,S., Barati,D., Sarvestani,S.K., Karaman,O. and Jabbari,E. (2013) Nanostructure Formation and
Transition from Surface to Bulk Degradation in Polyethylene Glycol Gels Chain-Extended with Short Hydroxy
Acid Segments. Biomacromolecules, 14, 2917-2928.
Moon,Y., Park,I., Cho,J., Um,J., Kim,T.H. and Lee,H. (2013) Berberine Inhibits Myofibroblast Differentiation in
Nasal PolypDerived Fibroblasts via the p38 Pathway. Phytotherapy Research, 27, 16-20.
Mun,C.H., Jung,Y., Kim,S., Kim,H.C. and Kim,S.H. (2013) Effects of Pulsatile Bioreactor Culture on Vascular Smooth
Muscle Cells Seeded on Electrospun Poly (lactidecoεcaprolactone) Scaffold. Artificial Organs 37, E168 –
E178.
Tiger Temporomandibular Disc
Murphy,M.K., Arzi,B., Vapniarsky-Arzi,N. and Athanasiou,K.A. (2013) Characterization of Degenerative Changes in
the Temporomandibular Joint of the Bengal Tiger (Panthera tigris tigris) and Siberian Tiger (Panthera tigris
altaica). Journal of comparative pathology, 149, 495-502.
Porcine Costochondral Cells
Murphy,M.K., Huey,D.J., Reimer,A.J., Hu,J.C. and Athanasiou,K.A. (2013) Enhancing Post-Expansion Chondrogenic
Potential of Costochondral Cells in Self-Assembled Neocartilage. PloS one, 8, e56983.
Tissue Engineered Vascular Graft
Naito,Y., Lee,Y.U., Yi,T., Church,S.N., Solomon,D., Humphrey,J.D., Shin'oka,T. and Breuer,C.K. (2013) Beyond
Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of TissueEngineered Vascular Grafts in the Venous Circulation Using a Murine Model. Tissue Engineering Part A. doi:
10.1089/ten.tea.2012.0613.
Polycystic Kidney Rat and Biliary Epithelial Cells (Cholangiocytes)
Nakanuma,Y., Sato,Y. and Harada,K. (2013) Tissue Culture Correlational Study of Genetic Cholangiopathy of
Autosomal Recessive Polycystic Kidney Disease. Epithelial Cell Culture Protocols. Methods in Molecular
Biology 945, 303 – 318.
Rabbit Adipose Tissue-Derived Mesenchymal Stem Cells
Neo,P.Y., See,E.Y., Toh,S.L. and Goh,J.C. (2013) Temporal profiling of the growth and multilineage potentiality of
adipose tissuederived mesenchymal stem cells cellsheets. Journal of tissue engineering and regenerative
medicine, doi: 10.1002/term.1776.
Murine Cardiac Fibroblasts
Novoyatleva,T., Schymura,Y., Janssen,W., Strobl,F., Swiercz,J.M., Patra,C., Posern,G., Wietelmann,A., Zheng,T.S.
and Schermuly,R.T. (2013) Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction.
Basic research in cardiology, 108, 1-13.
Decellularised Porcine Ileum
Nowocin,A.K., Southgate,A., Shurey,S., Sibbons,P., Gabe,S.M. and Ansari,T. (2013) The development and
implantation of a biologically derived allograft scaffold. Journal of tissue engineering and regenerative
medicine, doi: 10.1002/term.1722.
Human and Porcine Lung Tissue
O'Neill,J.D., Anfang,R., Anandappa,A., Costa,J., Javidfar,J., Wobma,H.M., Singh,G., Freytes,D.O., Bacchetta,M.D.
and Sonett,J.R. (2013) Decellularization of human and porcine lung tissues for pulmonary tissue
engineering. The Annals of thoracic surgery, 96, 1046-1056.
Kidney Sheets/Digests
O'Neill,J.D., Freytes,D.O., Anandappa,A.J., Oliver,J.A. and Vunjak-Novakovic,G.V. (2013) The regulation of growth
and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from
kidney. Biomaterials, 34, 9830-9841.
Primary Rat Osteoblasts
Orriss,I.R., Key,M.L., Hajjawi,M.O. and Arnett,T.R. (2013) Extracellular ATP Released by Osteoblasts Is A Key Local
Inhibitor of Bone Mineralisation. PloS one, 8, e69057.
Ovine Nasoseptal Chondrocytes
Oseni,A.O., Butler,P.E. and Seifalian,A.M. (2013) The application of POSS nanostructures in cartilage tissue
engineering: the chondrocyte response to nanoscale geometry. Journal of tissue engineering and
regenerative medicine, doi: 10.1002/term.1693.
Murine Lung
Park,B.S., Hong,G.U. and Ro,J.Y. (2013) Foxp3+-Treg Cells Enhanced by Repeated Low-Dose Gamma-Irradiation
Attenuate Ovalbumin-Induced Allergic Asthma in Mice. Radiation research, 179, 570-583.
Human Hepatic Stellate LX-2 Cells
Park,S.J., Sohn,H.Y. and Park,S.I. (2013) TRAIL Regulates Collagen Production through HSF1-dependent Hsp47
Expression in Activated Hepatic Stellate Cells. Cellular signalling 25, 1635 – 1643.
Fibroblasts
Park,S.J., Jun,Y.J., Kim,T.H., Jung,J.Y., Hwang,G.H., Jung,K.J., Lee,S.H., Lee,H.M. and Lee,S.H. (2013) Increased
expression of YKL-40 in mild and moderate/severe persistent allergic rhinitis and its possible contribution to
remodeling of nasal mucosa. American Journal of Rhinology & Allergy, 27, 372-380.
Chondrocytes
Park,Y.J. and Kim,J.K. (2013) The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage
Tissue Engineering Applications. Advances in Materials Science and Engineering,
http://dx.doi.org/10.1155/2013/853289.
Native Trachea
Partington,L., Mordan,N.J., Mason,C., Knowles,J.C., Kim,H.W., Lowdell,M.W., Birchall,M.A. and Wall,I. (2013)
Biochemical changes caused by decellularization may compromise mechanical integrity of tracheal
scaffolds. Acta Biomaterialia 9, 5251 – 5261.
Human Trabecular Meshwork Cells
Pattabiraman,P.P., Maddala,R. and Rao,P.V. (2013) Regulation of Plasticity and Fibrogenic Activity of Trabecular
Meshwork Cells by Rho GTPase Signaling. Journal of Cellular Physiology doi: 10.1002/jcp.24524.
Engineered Collagen Fibres
Paten,J.A., Tilburey,G.E., Molloy,E.A., Zareian,R., Trainor,C.V. and Ruberti,J.W. (2013) Utility of an opticallybased, micromechanical system for printing collagen fibers. Biomaterials 34, 2577 – 2587.
Human Aorta
Phillippi,J.A., Green,B.R., Eskay,M.A., Kotlarczyk,M.P., Hill,M.R., Robertson,A.M., Watkins,S.C., Vorp,D.A. and
Gleason,T.G. (2013) Mechanism of aortic medial matrix remodeling is distinct in patients with bicuspid
aortic valve. The Journal of thoracic and cardiovascular surgery, doi: 10.1016/j.jtcvs.2013.04.028.
Prewitz,M.C., Seib,F.P., von Bonin,M., Friedrichs,J., Sti+el,A., Niehage,C., Müller,K., Anastassiadis,K., Waskow,C.
and Hoflack,B. (2013) Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments.
Nature methods 10, 788 – 794.
Purnomo,Y., Piccart,Y., Coenen,T., van Pelt,J., Prihadi,J.S. and Lijnen,P.J. (2013) Oxidants and Antioxidants in
Medical Science 2, 5 – 10.
Cardiac Progenitor Cells
Rajabi-Zeleti,S., Jalili-Firoozinezhad,S., Azarnia,M., Khayyatan,F., Vahdat,S., Nikeghbalian,S., Khademhosseini,A.,
Baharvand,H. and Aghdami,N. (2014) The behavior of cardiac progenitor cells on macroporous pericardiumderived scaffolds. Biomaterials, 35, 970-982.
Murine and Human Lung
Reilkoff,R.A., Peng,H., Murray,L.A., Peng,X., Russell,T., Montgomery,R., Feghali-Bostwick,C., Shaw,A., Homer,R.J.
and Gulati,M. (2013) Semaphorin 7a+ Regulatory T Cells Are Associated with Progressive Idiopathic
Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-+¦1Çôinduced Pulmonary Fibrosis.
American journal of respiratory and critical care medicine, 187, 180-188.
Primary Human Dermal Fibroblasts
Remoué,N.l., Molinari,J., Andres,E., Lago,J.C., Barrichello,C. and Moreira,P.L. (2013) Development of an in vitro
model of menopause using primary human dermal fibroblasts. International journal of cosmetic science,
35, 546-554.
Mouse Respiratory Tract
Ronzani,C., Casset,A. and Pons,F. (2013) Exposure to multi-walled carbon nanotubes results in aggravation of
airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in
a mouse model of asthma. Archives of toxicology, doi: 10.1007/s00204-013-1116-3.
Primary Human Airway Smooth Muscle Cells
Roth,M., Zhong,J., Zumkeller,C., S’ng,C.T., Goulet,S. and Tamm,M. (2013) The Role of IgE-Receptors in IgEDependent Airway Smooth Muscle Cell Remodelling. PloS one, 8, e56015.
Murine Lung
Rothemund,S., Sönnichsen,F.D. and Polte,T. (2013) Therapeutic Potential of the Peptide Leucine Arginine As a New
Nonplant BowmanBirk-Like Serine Protease Inhibitor. Journal of medicinal chemistry, 56, 6732-6744.
Murine Lung
Ruiz,D.B., D'Alessandro-Gabazza,C.N., Toda,M., Takagi,T., Naito,M., Matsushima,Y., Matsumoto,T., Kobayashi,T.,
Gil-Bernabe,P. and Chelakkot-Govindalayathil,A.L. (2013) Differential Role of Regulatory T Cells in Early
and Late Stages of Pulmonary Fibrosis. Immunobiology 218, 245 – 254.
Rat Pancreatic Stellate Cells
Ryu,G.R., Lee,E., Chun,H.J., Yoon,K.H., Ko,S.H., Ahn,Y.B. and Song,K.H. (2013) Oxidative stress plays a role in high
glucose-induced activation of pancreatic stellate cells. Biochemical and biophysical research
communications, 439, 258-263.
Murine Lung
Saglani,S., Lui,S., Ullmann,N., Campbell,G.A., Sherburn,R.T., Mathie,S.A., Denney,L., Bossley,C.J., Oates,T. and
Walker,S.A. (2013) IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant
asthma. Journal of Allergy and Clinical Immunology 132, 676 – 685.e13.
Murine Lung
Sakai,M., Kubota,T., Ohnishi,H. and Yokoyama,A. (2013) A Novel Lung Injury Animal Model Using KL-6-Measurable
Human MUC1-Expressing Mice. Biochemical and Biophysical Research Communications 432, 460 – 465.
Murine Lung
Sayers,B.C., Taylor,A.J., Glista-Baker,E.E., Shipley-Phillips,J.K., Dackor,R.T., Edin,M.L., Lih,F.B., Tomer,K.B.,
Zeldin,D.C. and Langenbach,R. (2013) Role of COX-2 in Exacerbation of Allergen-Induced Airway Remodeling
by Multi-Walled Carbon Nanotubes. American Journal of Respiratory Cell and Molecular Biology 49, 525 –
535.
Murine Lung
Scotton,C.J., Hayes,B., Alexander,R., Datta,A., Forty,E.J., Mercer,P.F., Blanchard,A. and Chambers,R.C. (2013) Ex
vivo μCT analysis of bleomycin-induced lung fibrosis for pre-clinical drug evaluation. European Respiratory
Journal, doi: 10.1183/09031936.00182412.
Pleural Mesothelial Cells
Serve,K.M., Black,B., Szeinuk,J. and Pfau,J.C. (2013) Asbestos-associated mesothelial cell autoantibodies promote
collagen deposition in vitro. Inhalation Toxicology, 25, 774-784.
Cartilage Scaffold Analogs
Sharma,S., Panitch,A. and Neu,C.P. (2013) Incorporation of an Aggrecan Mimic Prevents Proteolytic Degradation of
Anisotropic Cartilage Analogs. Acta Biomaterialia 9, 4618 – 4625.
Adult Mouse Cardiac Fibroblasts
Siddesha,J.M., Valente,A.J., Sakamuri,S.S., Yoshida,T., Gardner,J.D., Somanna,N., Takahashi,C., Noda,M. and
Chandrasekar,B. (2013) Angiotensin II stimulates cardiac fibroblast migration via the differential regulation
of matrixins and RECK. Journal of molecular and cellular cardiology, 65, 9-18.
Human Breast Cancer Cells (HMLER)
Simic,P., Williams,E.O., Bell,E.L., Gong,J.J., Bonkowski,M. and Guarente,L. (2013) SIRT1 Suppresses the Epithelialto-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis. Cell reports 3, 1175 – 1186.
Mouse Fibroblast L929 Cells and Human Keratinocyte Cell Line (HaCat)
Siritientong,T., Ratanavaraporn,J., Srichana,T. and Aramwit,P. (2013) Preliminary Characterization of GenipinCross-Linked Silk Sericin/Poly (vinyl alcohol) Films as Two-Dimensional Wound Dressings for the Healing of
Superficial Wounds. BioMed Research International, http://dx.doi.org/10.1155/2013/904314.
Slominski,A., Janjetovic,Z., Tuckey,R.C., Nguyen,M.N., Bhattacharya,K.G., Wang,J., Li,W., Jiao,Y., Gu,W. and
Brown,M. (2013) 20S-Hydroxyvitamin D3, Noncalcemic Product of CYP11A1 Action on Vitamin D3, Exhibits
Potent Antifibrogenic Activity in Vivo. Journal of Clinical Endocrinology & Metabolism, 98, E298-E303.
Decellularised Rat, Porcine and Human Kidneys
Song,J.J., Guyette,J.P., Gilpin,S.E., Gonzalez,G., Vacanti,J.P. and Ott,H.C. (2013) Regeneration and experimental
orthotopic transplantation of a bioengineered kidney. Nature medicine, 19, 646-651.
Human Osteosarcoma-Derived Osteoblasts (MG63)
Stoppato,M., Carletti,E., Sidarovich,V., Quattrone,A., Unger,R.E., Kirkpatrick,C.J., Migliaresi,C. and Motta,A.
(2013) Influence of scaffold pore size on collagen I development: A new in vitro evaluation perspective.
Journal of Bioactive and Compatible Polymers, 28, 16-32.
Subramony,S.D., Su,A., Yeager,K. and Lu,H.H. (2013) Combined effects of chemical priming and mechanical
stimulation on mesenchymal stem cell differentiation on nanofiber scaffolds. Journal of Biomechanics,
http://dx.doi.org/10.1016/j.jbiomech.2013.10.016.
Murine Macrophage RAW264.7 Cells and Mouse Fibroblast L929 Cells
Sudsai,T., Wattanapiromsakul,C., Nakpheng,T. and Tewtrakul,S. (2013) Evaluation of the wound healing property of
Boesenbergia longiflora rhizomes. Journal of Ethnopharmacology, 150, 223-231.
Suh,K.S., Rhee,S.Y., Jung,W.W., Kim,N.J., Jang,Y.P., Kim,H.J., Kim,M.K., Choi,Y.K. and Kim,Y.S. (2013)
Chrysanthemum zawadskii extract protects osteoblastic cells from highly reducing sugar-induced oxidative
damage. International journal of molecular medicine, 32, 241.
Rat Lung
Sung,D.K., Kong,W.H., Park,K., Kim,J.H., Kim,M.Y., Kim,H. and Hahn,S.K. (2012) Noncovalenly PEGylated CTGF
siRNA/PDMAEMA complex for pulmonary treatment of bleomycin-induced lung fibrosis. Biomaterials 34,
1261 – 1269.
Murine Lung
Sunaga,H., Matsui,H., Ueno,M., Maeno,T., Iso,T., Syamsunarno,M.R.A., Anjo,S., Matsuzaka,T., Shimano,H. and
Yokoyama,T. (2013) Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice.
Nature communications, doi:10.1038/ncomms3563.
Murine Skin Fibroblast Scratch Wound
Tam,K., Suganya,C., Venugopal,J., Biswas,A., Choolani,M., Ramakrishna,S., Bongso,A. and Fong,C. (2013) A
Nanoscaffold Impregnated with Human Wharton's Jelly Stem Cells or Its Secretions Improves Healing of
Wounds. Journal of Cellular Biochemistry, doi: 10.1002/jcb.24723.
Human Fibrotic Livers
Tan,Z., Qian,X., Jiang,R., Liu,Q., Wang,Y., Chen,C., Wang,X., Ryffel,B. and Sun,B. (2013) IL-17A plays a critical
role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. The Journal of
Immunology, 191, 1835-1844.
Murine Lung
Tang,N., Zhao,Y., Feng,R., Liu,Y., Wang,S., Wei,W., Ding,Q., An,M.S., Wen,J. and Li,L. (2013) Lysophosphatidic
acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts.
Journal of cellular and molecular medicine, doi: 10.1111/jcmm.12178.
Human Scleral Fibroblasts
Tao,Y., Pan,M., Liu,S., Fang,F., Lu,R., Lu,C., Zheng,M., An,J., Xu,H. and Zhao,F. (2013) cAMP Level Modulates
Scleral Collagen Remodeling, a Critical Step in the Development of Myopia. PloS one, 8, e71441.
Teh,T.K., Toh,S.L. and Goh,J.C. (2013) Aligned Fibrous Scaffolds for Enhanced Mechanoresponse and Tenogenesis of
Mesenchymal Stem Cells. Tissue Engineering Part A, 19, 1360-1372.
Murine Primary Calvarial Osteoblasts
Thiele,F., Cohrs,C.M., Przemeck,G.K., Wurst,W., Fuchs,H. and de Angelis,M.H. (2013) In vitro analysis of bone
phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system.
Journal of bone and mineral metabolism, 31, 293 – 303.
Thomas,L.V. and Nair,P.D. (2013) The Effect of Pulsatile Loading and Scaffold Structure for the Generation of a
Medial Equivalent Tissue Engineered Vascular Graft. BioResearch open access, 2, 227-239.
Tirkkonen,L., Haimi,S., Huttunen,S., Wolff,J., Pirhonen,E., S+índor,G.K. and Miettinen,S. (2013) Osteogenic
medium is superior to growth factors in differentiation of human adipose stem cells towards bone-forming
cells in 3D culture. European Cells and Materials, 25, 144 – 158.
Murine Skin and Cultured Fibroblasts
Tomcik,M., Zerr,P., Pitkowski,J., Palumbo-Zerr,K., Avouac,J., Distler,O., Becvar,R., Senolt,L., Schett,G. and
Distler,J.H. (2013) Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent
fibrosis. Annals of the rheumatic diseases, doi: 10.1136/annrheumdis-2012-203095.
Tseng,C.M., Hsiao,Y.H., Su,V.Y.-F., Su,K.C., Wu,Y.C., Chang,K.T. and Perng,D.W. (2013) The Suppression Effects of
Thalidomide on Human Lung Fibroblasts: Cell Proliferation, Vascular Endothelial Growth Factor Release, and
Collagen Production. Lung 191, 361 - 368.
Murine Lung Upper Right Lobe
Tully,J.E., Hoffman,S.M., Lahue,K.G., Nolin,J.D., Anathy,V., Lundblad,L.K., Daphtary,N., Aliyeva,M., Black,K.E.
and Dixon,A.E. (2013) Epithelial NF-κB Orchestrates House Dust MiteInduced Airway Inflammation,
Hyperresponsiveness, and Fibrotic Remodeling. The Journal of Immunology, 191, 5811-5821.
Murine Primary Cardiac Fibroblasts
Valente,A.J., Sakamuri,S.S., Siddesha,J.M., Yoshida,T., Gardner,J.D., Prabhu,R., Siebenlist,U. and Chandrasekar,B.
(2013) TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation. Cellular
signalling, 25, 2176-2184.
Murine Lung
Veerappan,A., O'Connor,N.J., Brazin,J., Reid,A.C., Jung,A., McGee,D., Summers,B., Branch-Elliman,D., Stiles,B.
and Worgall,S. (2013) Mast Cells: A Pivotal Role in Pulmonary Fibrosis. DNA and cell biology, 32, 206-218.
Murine Lung
Walters,D.M., White,K.M., Patel,U., Davis,M.J., Veluci-Marlow,R.M., Sunkesula,S.R.B., Bonner,J.C., Martin,J.R.,
Gladwell,W. and Kleeberger,S.R. (2013) Genetic susceptibility to interstitial pulmonary fibrosis in mice
induced by vanadium pentoxide (V2O5). The FASEB Journal, doi: 10.1096/fj.13-235044.
Rat Tail Intervertebral Discs
Wang,I.C., Liu,H.T., Yu,C.M., Whu,S.W., Lin,S.S., Su,C.I., Chen,C.H. and Chen,W.J. (2013) Effect of hyperbaric
oxygenation on intervertebral disc degeneration: An in vivo study with Sprague-Dawley rats. Spine, 38,
E137-E142.
Lung Tissue
Wang,X., Ji,Z., Chang,C.H., Zhang,H., Wang,M., Liao,Y., Lin,S., Meng,H., Li,R. and Sun,B. (2013) Use of Coated
Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and
Lung Toxicological Potential. Small, doi: 10.1002/smll.201301597.
White Rabbit Bone Marrow Mesenchymal Stem Cells
Wei,B., Jin,C., Xu,T., Tang,C., Hu,W. And Wang.L. (2013) Effect of Bone Marrow Besenchymal Stem Cells-Derived
extracellular Matrix Scaffold on Chondrogenic Differentiation of Marrow Clot after Microfracture of Bone
Marrow stimulation In Vitro. Chinese Journal of Reparative and Reconstructive Surgery, 27, 464.
Human Myometrial Biopsy Samples
Wendremaire,M., Mourtialon,P., Goirand,F., Lirussi,F.d.r., Barrichon,M., Hadi,T., Garrido,C., Le Ray,I., Dumas,M.
and Sagot,P. (2013) Effects of Leptin on Lipopolysaccharide-Induced Remodeling in an In Vitro Model of
Human Myometrial Inflammation 1. Biology of Reproduction, 88, Article 45, 1 – 10.
Horse Lung
Williams,K.J., Robinson,N.E., Lim,A., Brandenberger,C., Maes,R., Behan,A. and Bolin,S.R. (2013) Experimental
Induction of Pulmonary Fibrosis in Horses with the Gammaherpesvirus Equine Herpesvirus 5. PloS one, 8,
e77754.
Wu,C.S., Hsu,Y.C., Yeh,J.t., Liao,H.T., Jhang,J.J. and Sie,Y.Y. (2013) Biocompatibility and characterization of
renewable agricultural residues and polyester composites. Carbohydrate Polymers 94, 584 – 593.
Wu,C.S. and Liao,H.T. (2013) The mechanical properties, biocompatibility and biodegradability of chestnut shell
fibre and polyhydroxyalkanoate composites. Polymer Degradation and Stability,
http://dx/dpo/prg/10.1016/j.polymdegradstab.2013.10.019.
Osteoprogenitor MC3T3-E1 Cells
Wu,L.C., Liu,H.W., Chen,C.K., Kuo,J.T., Chou,H.K. and Chung,Y.C. (2013) The Effect on a New Sintered Calcium
Sulfate Ceramic to Osteoprogenitor MC 3T3-E1. Advanced Materials Research, 677, 201-206.
Murine Skin
Wu,M., Pedroza,M., Lafyatis,R., George,A., Mayes,M.D., Assassi,S., Tan,F.K., Brenner,M.B. and Agarwal,S.K. (2013)
Identification of cadherin11 as a mediator of dermal fibrosis and possible role in systemic sclerosis.
Arthritis & Rheumatism, doi:10.1002/art.38275.
Lung
Xi,Y., Tan,K., Brumwell,A.N., Chen,S., Kim,Y.H., Kim,T.J., Wei,Y. and Chapman,H.A. (2013) Inhibition of Epithelial
to Mesenchymal Transition and Pulmonary Fibrosis by Methacycline. American Journal of Respiratory Cell
and Molecular Biology, http://www.atsjournals.org/doi/abs/10.1165/rcmb.2013-00990c.
Human Lung Fibroblasts (HFL-1)
Yang,M., Zhao,X., Liu,Y., Tian,Y., Ran,X. and Jiang,Y. (2013) A role for WNT1-inducible signaling protein-1 in
airway remodeling in a rat asthma model. International immunopharmacology 17, 350 – 357.
Murine Lung
Yang,S., Cui,H., Xie,N., Icyuz,M., Banerjee,S., Antony,V.B., Abraham,E., Thannickal,V.J. and Liu,G. (2013) miR-145
regulates myofibroblast differentiation and lung fibrosis. The FASEB Journal, 27, 2382-2391.
Murine Lung
Yee,M., Buczynski,B.W., Lawrence,B.P. and O'Reilly,M.A. (2013) Neonatal Hyperoxia Increases Sensitivity of Adult
Mice to Bleomycin-Induced Lung Fibrosis. American Journal of Respiratory Cell and Molecular Biology, 48,
258-266.
Rat Lung
Yoo,H.S., Chang,Y.S., Kim,J.K., Ahn,S.Y., Kim,E.S., Sung,D.K., Jeon,G.W., Hwang,J.H., Shim,J.W. and Park,W.S.
(2013) Antenatal betamethasone attenuates intrauterine infection-aggravated hyperoxia-induced lung injury
in neonatal rats. Pediatric research, 73, 726-733.
Anterior Cruciate Ligament on Three-Dimensional Collagen Scaffolds
Yoshida,R. and Murray,M.M. (2013) Peripheral blood mononuclear cells enhance the anabolic effects of plateletrich
plasma on anterior cruciate ligament fibroblasts. Journal of Orthopaedic Research, 31, 29-34.
Equine Tendons
Youngstrom,D.W., Barrett,J.G., Jose,R.R. and Kaplan,D.L. (2013) Functional Characterization of DetergentDecellularized Equine Tendon Extracellular Matrix for Tissue Engineering Applications. PloS one, 8, e64151.
Anterior Cruciate Ligament Fibroblasts
Yoshida,R. and Murray,M.M. (2013) Peripheral blood mononuclear cells enhance the anabolic effects of plateletrich
plasma on anterior cruciate ligament fibroblasts. Journal of Orthopaedic Research, 31, 29-34.
Murine Colon Tissue
Yuan,C., Chen,W.X., Zhu,J.S., Chen,N.W., Lu,Y.M., Ou,Y.X. and Chen,H.Q. (2013) IL-10 Treatment Is Associated
with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model. Mediators of
inflammation, http://dx.doi.org/10.1155/2013/617145.
Human Noduels of Fibroblasts from Duchenne Muscular Dystrophy Muscle
Zanotti,S., Gibertini,S., Savadori,P., Mantegazza,R. and Mora,M. (2013) Duchenne muscular dystrophy fibroblast
nodules: a cell-based assay for screening anti-fibrotic agents. Cell and tissue research, 352, 659 - 670.
Rat Cardiac Tissue
Zhang,H., Zhong,H., Everett IV,T.H., Wilson,E., Chang,R., Zeng,D., Belardinelli,L. and Olgin,J.E. (2013) Blockade of
A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias one week after
myocardial infarction in the rat model. Heart Rhythm, http://dx.doi.org/10.1016/j.hrthm.2013.10.023.
Murine Lung
Zhou,Y., Kang,M.J., Jha,B.K., Silverman,R.H., Lee,C.G. and Elias,J.A. (2013) Role of Ribonuclease L in Viral
Pathogen-Associated Molecular Pattern/Influenza Virus and Cigarette SmokeInduced Inflammation and
Remodeling. The Journal of Immunology, 191, 2637-2646.
Neonatal Rat Ventricular Cardiomyocytes and Cardiac Fibroblasts
Zhu,W., Zhao,Y., Xu,Y., Sun,Y., Wang,Z., Yuan,W. and Du,Z. (2013) Dissection of Protein Interactomics Highlights
MicroRNA Synergy. PloS one, 8, e63342.
Murine Embryonic Fibroblasts (MEFs) and Rat and Human Idiopathic Pulmonary Fibrosis Lung Fibroblasts
Zimmerman,K.A., Graham,L.V., Pallero,M.A. and Murphy-Ullrich,J.E. (2013) Calreticulin Regulates Transforming
Growth Factor-β-stimulated Extracellular Matrix Production. Journal of Biological Chemistry, 288, 1458414598.
Murine Lung
Ziobro,R., Henry,B., Edwards,M.J., Lentsch,A.B. and Gulbins,E. (2013) Ceramide mediates lung fibrosis in cystic
fibrosis. Biochemical and biophysical research communications 434, 705 – 709.
Primary Human Colonic Myofibroblast Cell Line (CCD-18Co Cells)
Ziogas,D.C., Gras-Miralles,B., Mustafa,S., Geiger,B.M., Najarian,R.M., Nagel,J.M., Flier,S.N., Popov,Y., Tseng,Y.H.
and Kokkotou,E. (2013) Anti-melanin-concentrating hormone treatment attenuates chronic experimental
colitis and fibrosis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 304, G876-G884.
2012
Human Fibroblasts
Akhmetshina,A., Palumbo,K., Dees,C., Bergmann,C., Venalis,P., Zerr,P., Horn,A., Kireva,T., Beyer,C. and
Zwerina,J. (2012) Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nature
Communications, 3, 735.
Alvarez Perez,M.A., Guarino,V., Cirillo,V. and Ambrosio,L. (2012) In vitro mineralization and bone osteogenesis in
poly ε-caprolactone)/gelatin nanofibers. Journal of Biomedical Materials Research Part A, doi:
10.1002/jbm.a.34233.
Murine Lung
Anathy,V., Roberson,E., Cunniff,B., Nolin,J., Hoffmann,S., Spiess,P., Guala,A.S., Lahue,K., Goldman,D. and
Flemer,S. (2012) Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of
apoptosis. Molecular and Cellular Biology, 32, 3464 - 3478.
Articular Cartilage Tissue
Antipova,O. and Orgel,J.P.R.O. (2012) Non-Enzymatic Decomposition of Collagen Fibers by a Biglycan Antibody and
a Plausible Mechanism for Rheumatoid Arthritis. PLoS ONE, 7, e32241.
Rat Lung Tissue
Aoki,Y., Kojo,Y., Yamada,S. and Onoue,S. (2012) Respirable dry powder formulation of bleomycin for developing a
pulmonary fibrosis animal model. Journal of Pharmaceutical Sciences, 101, 2074 - 2081.
Murine Lung Tissue
Aono,Y., Ledford,J.G., Mukherjee,S., Ogawa,H., Nishioka,Y., Sone,S., Beers,M.F., Noble,P.W. and Wright,J.R.
(2012) Surfactant Protein-D Regulates Effector Cell Function and Fibrotic Lung Remodeling in Response to
Bleomycin Injury. American Journal of Respiratory and Critical Care Medicine, 185, 525-536.
Undetermined Model
Azad,N., Iyer,A.K.V., Wang,L., Liu,Y., Lu,Y. and Rojanasakul,Y. (2012) Reactive oxygen species-mediated p38 MAPK
regulates carbon nanotube-induced fibrogenic and angiogenic responses. Nanotoxicology, doi:
10.3109/17435390.2011.647929.
Human Colon Adenocarcinoma Cell Line (SW480)
Baker,A.M., Bird,D., Lang,G., Cox,T.R. and Erler,J.T. (2012) Lysyl oxidase enzymatic function increases stiffness to
drive colorectal cancer progression through FAK. Oncogene, doi: 10.1038/onc.2012.202.
Porcine Aortic Valve Cusps
Balachandran,K., Hussain,S., Yap,C.H., Padala,M., Chester,A.H. and Yoganathan,A.P. (2012) Elevated cyclic stretch
and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT2Areceptor-dependent
pathway. Cardiovascular Pathology, 21, 206-213.
Murine Fibroblast Cell Line (L929 Cells)
Balekar,N., Katkam,N.G., Nakpheng,T., Jehtae,K. and Srichana,T. (2012) Evaluation of the wound healing potential
of Wedelia trilobata (L.) leaves. Journal of Ethnopharmacology, 141, 817 – 824.
Murine Lung
Banerjee,E.R., Laflamme,M.A., Papayannopoulou,T., Kahn,M., Murry,C.E. and Henderson,W.R. (2012) Human
embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a
xenograft transplant mouse model. PloS one, 7, e33165.
Murine Lung
Banerjee,E.R. and Henderson,W.R. (2012) Characterization of lung stem cell niches in a mouse model of bleomycininduced fibrosis. Stem Cell Research & Therapy, 3, 21.
Murine Lung
Banerjee,E.R., Laflamme,M.A., Papayannopoulou,T., Kahn,M., Murry,C.E. and Henderson,W.R. (2012) Human
embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a
xenograft transplant mouse model. PLoS One, 7, e33165.
Fibroblasts
Bhattacharyya,S., Kelley,K., Melichian,D., Tamaki,Z., Fang,F., Su,Y., Feng,G., Pope,R.M., Budinger,G.R. and
Mutlu,G.M. (2012) Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses: A
Novel Mechanism for Maintaining and Amplifying Fibrosis in Scleroderma. The American journal of
pathology 182, 192 – 205.
Beyer,C., Reich,N., Schindler,S.C., Akhmetshina,A., Dees,C., Tomcik,M., Hirth-Dietrich,C., von Degenfeld,G.,
Sandner,P. and Distler,O. (2012) Stimulation of soluble guanylate cyclase reduces experimental dermal
fibrosis. Annals of the Rheumatic Diseases, 71, 1019 - 1026.
Fibroblasts and Lung Tissue
Bolaños,A.L., Milla,C.M., Lira,J.C., Ram+¡rez,R., Checa,M., Barrera,L., García-Alvarez,J., Carbajal,V., Becerril,C.
and Gaxiola,M. (2012) Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. American Journal of
Physiology-Lung Cellular and Molecular Physiology, 303, L978-L990.
Human Dermal Decellularised Membrane
Bondioli,E., Fini,M., Veronesi,F., Giavaresi,G., Tschon,M., Cenacchi,G., Cerasoli,S., Giardino,R. and Melandri,D.
(2012) Development and evaluation of a decellularized membrane from human dermis. Journal of Tissue
Engineering and Regenerative Medicine, doi: 10.1002/term.1530.
Murine Lung
Bönisch,U., Böhme,A., Kohajda,T., Mögel,I., Schütze,N., von Bergen,M., Simon,J.C., Lehmann,I. and Polte,T.
(2012) Volatile Organic Compounds Enhance Allergic Airway Inflammation in an Experimental Mouse Model.
PloS one, 7, e39817.
Murine Lung
Buczynski,B.W., Yee,M., Paige Lawrence,B. and O'Reilly,M.A. (2012) Lung development and the host response to
influenza A virus are altered by different doses of neonatal oxygen in mice. American Journal of
Physiology-Lung Cellular and Molecular Physiology, 302, L1078-L1087.
Adipose Tissue Derived Mesenchymal Stem Cells
Carvalho,L.R.P., Breyner,N.M., Hell,R.C.R., Valério,P., Novikoff,S. and Goes,A.M. (2012) Healing Pattern in
Calvarial Bone Defects Following Bone Regeneration in Rats Guided by Chitosan Scaffold and Adipose TissueDerived Mesenchymal Stem Cells. Open Tissue Engineering and Regenerative Medicine Journal, 5, 25-34.
Rat Cardiac Fibroblasts and Myofibroblasts
Catalán,M., Smolic,C., Contreras,A., Ayala,P., Olmedo,I., Copaja,M., Boza,P., Vivar,R., Avalos,Y. and Lavandero,S.
(2012) Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and
myofibroblast. Toxicology and Applied Pharmacology 261, 300 – 308.
Murine Skeletal Muscle Fibroblasts (NOR-10) and Myoblasts (C2C12) Cells
Cha,M.C. and Purslow,P.P. (2012) Expressions of matrix metalloproteinases and their inhibitor are modified by betaadrenergic agonist Ractopamine in skeletal fibroblasts and myoblasts. Canadian Journal of Animal Science,
92, 159 - 166.
Mouse Cardiac Fibroblasts
Chan,E.C., Peshavariya,H.M., Liu,G.S., Jiang,F., Lim,S.Y. and Dusting,G.J. (2012) Nox4 modulates collagen
production stimulated by transforming growth factor β1 in vivo and in vitro. Biochemical and Biophysical
Research Communications, http://dx.doi.org/10.1016/j.bbrc.2012.11.138.
Rabbit Tibia Periosteal Progenitor Cells
Chang,C., Chen,C., Liu,H., Whu,S., Chen,S., Tsai,C. and Hsiue,G. (2012) Bioengineered periosteal progenitor cell
sheets to enhance tendon-bone healing in a bone tunnel. Biomedical Journal, 35, 473 - 480.
Bone Marrow-Derived Mesenchymal Stem Cell (BMSC)
Chen,K., Sahoo,S., He,P., Ng,K.S., Toh,S.L. and Goh,J.C.H. (2012) A Hybrid Silk/RADA-Based Fibrous Scaffold with
Triple Hierarchy for Ligament Regeneration. Tissue Engineering Part A. 18, 1399 - 1409.
Rabbit Bone Marrow Stromal Cells and Osteoblasts Co-Culture
Chen,K., Teh,T.K.H., Ravi,S., Toh,S.L. and Goh,J.C.H. (2012) Osteochondral Interface Generation by Rabbit Bone
Marrow Stromal Cells and Osteoblasts Co-culture. Tissue Engineering 18, 1902 - 1911.
Human Periodontal Ligaments
Chen,Y.J., Jeng,J.H., Chang,H.H., Huang,M.Y., Tsai,F.F. and Jane Yao,C.C. (2012) Differential regulation of
collagen, lysyl oxidase and MMP2 in human periodontal ligament cells by lowand highlevel mechanical
stretching. Journal of Periodontal Research, doi: 10.1111/jre.12028.
Dog Articular Cartilage
Cheong-Ho,C. (2012) Cartilage Regeneration Using a Fibrin and Autologous Cultured Chondrocytes Mixture in a
Canine Model. Journal of Tissue Science & Engineering 3, 114.
Chiang,H.M., Chen,H.C., Lin,T.J., Shih,I. and Wen,K.C. (2012) Michelia alba extract attenuates UVB-induced
expression of matrix metalloproteinases via MAP kinase pathway in human dermal fibroblasts. Food and
Chemical Toxicology 50, 4260 – 4269.
Cho,J.S., Moon,Y.M., Park,I.H., Um,J.Y., Moon,J.H., Park,S.J., Lee,S.H., Kang,H.J. and Lee,H.M. (2012) Epigenetic
regulation of myofibroblast differentiation and extracellular matrix production in nasal polypderived
fibroblasts. Clinical & Experimental Allergy, 42, 872 - 882.
Osteoblastic MC3T3-E1 Cells
Choi,E.M. (2012) Sunflower seed extract enhances the differentiation of osteoblastic MC3T3-E1 cells. Food and
Agricultural Immunology doi: 10.1080/09540105.2012.716399.
Human Placenta-Derived Extracellular Matrix
Choi,J.S., Kim,J.D., Yoon,H.S. and Cho,Y.W. (2012) Full-Thickness Skin Wound Healing Using Human PlacentaDerived Extracellular Matrix Containing Bioactive Molecules. Tissue Engineering Part A. 19, 329 – 339.
Porcine Adipose Tissue
Choi,Y.C., Choi,J.S., Kim,B.S., Kim,J.D., Yoon,H.I. and Cho,Y.W. (2012) Decellularized Extracellular Matrix Derived
from Porcine Adipose Tissue as a Xenogeneic Biomaterial for Tissue Engineering. Tissue Engineering Part C:
Methods, 18, 866 - 876.
Primary Human Osteoblasts
Chopra,K., Mummery,P.M., Derby,B. and Gough,J.E. (2012) Gel-cast glass-ceramic tissue scaffolds of controlled
architecture produced via stereolithography of moulds. Biofabrication, 4, 045002.
Rat Lung Fibroblasts
Chou,H.C., Lang,Y.D., Wang,L.F., Wu,T.Y., Hsieh,Y.F. and Chen,C.M. (2012) Angiotensin II Type 1 Receptor
Antagonist Attenuates Lung Fibrosis in Hyperoxia-Exposed Newborn Rats. Journal of Pharmacology and
Experimental Therapeutics 340, 169-175.
Human and Murine Skin
Dees,C., Tomcik,M., PalumboZerr,K., Akhmetshina,A., Beyer,C., Lang,V., Horn,A., Zerr,P., Zwerina,J. and
Gelse,K. (2012) JAK2 as a novel mediator of the profibrotic effects of TGFβ in systemic sclerosis. Arthritis
& Rheumatism, 64, 3006 - 3015.
Kidney Tissue
Djudjaj,S., Chatziantoniou,C., Raffetseder,U., Guerrot,D., Dussaule,J.C., Boor,P., Kerroch,M., Hanssen,L.,
Brandt,S. and Dittrich,A. (2012) Notch3 receptor activation drives inflammation and fibrosis following
tubulointerstitial kidney injury. The Journal of Pathology 228, 286 – 299.
Human Colonic Epithelial Cell lines and Primary Human Colonic Subepithelial Myofibroblasts
Drygiannakis,I., Valatas,V., Sfakianaki,O., Bourikas,L., Manousou,P., Kambas,K., Ritis,K., Kolios,G. and
Kouroumalis,E. (2012) Proinflammatory cytokines induce crosstalk between colonic epithelial cells and
subepithelial myofibroblasts: Implication in intestinal fibrosis. Journal of Crohn's and Colitis,
http://dx.doi.org/10.1016/j.crohns.2012.04.008.
Human Cardiac Tissue
de Jong,S., van Veen,T.A.B., de Bakker,J.M.T. and van Rijen,H.V.M. (2012) Monitoring cardiac fibrosis: a technical
challenge. Netherlands Heart Journal 20, 44 – 48.
Wharton’s Jelly-Derived Mesenchymal Stromal Cells
Du,T., Cheng,J., Zhong,L., Zhao,X.F., Zhu,J., Zhu,Y.J. and Liu,G.H. (2012) The alleviation of acute and chronic
kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemiareperfusion injury via an endocrine mechanism. Cytotherapy, 14, 1215 - 1227.
A549 Cells and Human Bronchial Cells, Lung Tissue
Dunmore,R., Carruthers,A.M., Bell,M.J., Zhang,H., Hogaboam,C.M., Peng,X., Herzog,E.L., Knight,D.A.,
Martinez,F.J. and Sleeman,M.A. (2012) An Assessment of Epithelial and Mesenchymal Phenotypes in
Experimental and Clinical Pulmonary Fibrosis doi: 10.5402/2012/153971.
Articular Cartilage Constructs
Eleswarapu,S.V. and Athanasiou,K.A. (2012) TRPV4 channel activation improves the tensile properties of selfassembled articular cartilage constructs. Acta Biomaterialia,
http://dx.doi.org/10.1016/j.actbio.2012.10.031.
Human Tendon Fibroblasts
Erisken,C., Zhang,X., Moffat,K.L., Levine,W.N. and Lu,H.H. (2012) Scaffold Fiber Diameter Regulates Human
Tendon Fibroblast Growth and Differentiation. Tissue Engineering Part A, 19, 519 – 528.
Murine Liver Tissue
Fairfax,K.C., Amiel,E., King,I.L., Freitas,T.C., Mohrs,M. and Pearce,E.J. (2012) IL-10R Blockade during Chronic
Schistosomiasis Mansoni Results in the Loss of B Cells from the Liver and the Development of Severe
Pulmonary Disease. PLoS Pathogens, 8, e1002490.
Bone
Ferreira,A.M., Gentile,P., Sartori,S., Pagliano,C., Cabrele,C., Chiono,V. and Ciardelli,G. (2012) Biomimetic soluble
collagen purified from bones. Biotechnology Journal 7, 1386 – 1394.
Murine and Human Fibrocytes
Field,J.J., Burdick,M.D., DeBaun,M.R., Strieter,B.A., Liu,L., Mehrad,B., Rose,C.E., Linden,J. and Strieter,R.M.
(2012) The Role of Fibrocytes in Sickle Cell Lung Disease. PloS one, 7, e33702.
Murine Lung Tissue
Fujino,N., Kubo,H., Suzuki,T., He,M., Suzuki,T., Yamada,M., Takahashi,T., Ota,C. and Yamaya,M. (2012)
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung
injury in mice. Experimental Lung Research 38, 28 – 36.
Murine Bladder Tissue
Fu,C.L., Odegaard,J.I., De'Broski,R.H. and Hsieh,M.H. (2012) A Novel Mouse Model of Schistosoma haematobium
Egg-Induced Immunopathology. PLoS Pathogens, 8, e1002605.
Murine Lung Tissue
Fujino,N., Kubo,H., Suzuki,T., He,M., Suzuki,T., Yamada,M., Takahashi,T., Ota,C. and Yamaya,M. (2012)
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung
injury in mice. Experimental Lung Research, 38, 28 – 36.
Rat Lung
Gao,F., Fish,B.L., Szabo,A., Doctrow,S.R., KMA,L., Molthen,R.C., Moulder,J.E., Jacobs,E.R. and Mdehora,M. (2012)
Short-Term Treatment with a SOD/Catalase Mimetic, EUK-207, Mitigates Pneumonitis and Fibrosis after
Single-Dose Total-Body or Whole-Thoracic Irradiation. Radiation Research, 178, 468-480.
Murine Lung
Giannandrea,M., Yee,M., O'Reilly,M.A. and Lawrence,B.P. (2012) Memory CD8+ T cells are sufficient to alleviate
impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation. Clinical
and Vaccine Immunology, 19, 1432-1441.
Rat Bone Marrow Mesenchymal Stem Cells
Gomide,V.S., Zonari,A., Ocarino,N.M., Goes,A.M., Serakides,R. and Pereira,M.M. (2012) In vitro and in vivo
osteogenic potential of bioactive glassPVA hybrid scaffolds colonized by mesenchymal stem cells.
Biomedical Materials, 7, 015004.
Murine Lung Tissue
Gorshkova,I., Zhou,T., Mathew,B., Jacobson,J.R., Takekoshi,D., Bhattacharya,P., Smith,B., Aydogan,B.,
Weichselbaum,R.R. and Natarajan,V. (2012) Inhibition of serine palmitoyltransferase delays the onset of
radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.
Journal of Lipid Research, doi: 10.1194/jlr.M026039.
Lamb Trachea and Amniotic Mesenchymal Stem Cells
Gray,F.L., Turner,C.G., Ahmed,A., Calvert,C.E., Zurakowski,D. and Fauza,D.O. (2012) Prenatal tracheal
reconstruction with a hybrid amniotic mesenchymal stem cellsengineered construct derived from
decellularized airway. Journal of Pediatric Surgery, 47, 1072-1079.
Murine Abdominal Wall Wound
Hoffman,A., Baxter,R., Nasar,A., Gardner,T.R., Kumara,S., Cordon-Cardo,C., Ahmed,A., Newman,R.A., Zmora,O.
and Whelan,R.L. (2012) Perioperative Polyphenon E, a Green Tea Extract, Does Not Affect the Wound
Complication Rate in Mice After Sham Laparotomy yet Has an Inhibitory Effect on Wound Healing. Surgical
Innovation, 19, 399 - 406.
Hong,S.M., Lee,H.M., Chung,S.W., Park,H., Cho,J.S., Um,J.Y. and Lee,H.R. (2012) Effect of Caffeic Acid on Nasal
Polyp Derived Fibroblasts. Otolaryngology--Head and Neck Surgery, 147, 245.
Murine Fibroblasts and Skin
Horn,A., Palumbo,K., Cordazzo,C., Dees,C., Akhmetshina,A., Tomcik,M., Zerr,P., Avouac,J., Gusinde,J. and
Zwerina,J. (2012) Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.
Arthritis & Rheumatism, 64, 2724 - 2733.
Human Embryonic Skin Fibroblasts
Hsiao,C.Y., Hung,C.Y., Tsai,T.H. and Chak,K.F. (2012) A Study of the Wound Healing Mechanism of a Traditional
Chinese Medicine, Angelica sinensis, Using a Proteomic Approach. Evidence-Based Complementary and
Alternative Medicine, doi: 10.1155/2012.467531.
Fibroblasts and Rat Wound
Hsiao,C.Y., Tsai,T.H. and Chak,K.F. (2012) The Molecular Basis of Wound Healing Processes Induced by Lithospermi
Radix: A Proteomics and Biochemical Analysis. Evidence-Based Complementary and Alternative Medicine,
doi: 10.1155/2012/508972
Human and Murine Skin
Hu,B., Castillo,E., Harewood,L., Ostano,P., Reymond,A., Dummer,R., Raffoul,W., Hoetzenecker,W.,
Hofbauer,G.F.L. and Dotto,G.P. (2012) Multifocal Epithelial Tumors and Field Cancerization from Loss of
Mesenchymal CSL Signaling. Cell, 149, 1207-1220.
Heart Valves
Huang,H.Y.S., Balhouse,B.N. and Huang,S. (2012) Application of Simple Biomechanical and Biochemical Tests to
Heart Valve Leaflets: Implications for Heart Valve Characterization and Tissue Engineering. Proceedings of
the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine doi:
10.1177/0954411912455004.
Human Cartilage Explants Culture and Chondrocytes
Huh,J.E., Seo,B.K., Baek,Y.H., Lee,S., Lee,J.D., Choi,D.Y. and Park,D.S. (2012) Standardized butanol fraction of
WIN-34B suppresses cartilage destruction via inhibited production of matrix metalloproteinase and
inflammatory mediator in osteoarthritis human cartilage explants culture and chondrocytes. BMC
Complementary and Alternative Medicine, 12, 256.
Human Fibroblasts
Iyer,P., Walker,K.J. and Madihally,S.V. (2012) Increased matrix synthesis by fibroblasts with decreased proliferation
on synthetic chitosan-gelatin porous structures. Biotechnology and Bioengineering 109, 1314 – 1325.
Porcine Wounds
Jackson,J.E., Kopecki,Z., Adams,D.H. and Cowin,A.J. (2012) Flii neutralizing antibodies improve wound healing in
porcine preclinical studies. Wound Repair and Regeneration, 20, 523 – 536.
Chondrogenic-Induced Bone Mesenchymal Stem Cells
Jia,S., Liu,L., Pan,W., Meng,G., Duan,C., Zhang,L., Xiong,Z. and Liu,J. (2012) Oriented cartilage extracellular
matrix-derived scaffold for cartilage tissue engineering. Journal of Bioscience and Bioengineering, 113, 647
- 653.
Chondrogenic-Induced Bone Mesenchymal Stem Cells
Jia,S., Liu,L., Pan,W., Meng,G., Duan,C., Zhang,L., Xiong,Z. and Liu,J. (2012) Oriented cartilage extracellular
matrix-derived scaffold for cartilage tissue engineering. Journal of Bioscience and Bioengineering,
http://dx.doi.org/10.1016/j.jbiosc.2011.12.009.
Human Patellar Tendon Fibroblasts
Jiang,C., Shao,L., Wang,Q. and Dong,Y. (2012) Repetitive mechanical stretching modulates transforming growth
factor-β induced collagen synthesis and apoptosis in human patellar tendon fibroblasts. Biochemistry and
Cell Biology, 90, 667-674.
Rat Lung
Jiang,J.S., Lang,Y.D., Chou,H.C., Shih,C.M., Wu,M.Y., Chen,C.M. and Wang,L.F. (2012) Activation of the ReninAngiotensin System in Hyperoxia-Induced Lung Fibrosis in Neonatal Rats. Neonatology, 101, 47-54.
Human Rotator Cuff Tendon Tenocytes
Jo,C.H., Kim,J.E., Yoon,K.S. and Shin,S. (2012) Platelet-Rich Plasma Stimulates Cell Proliferation and Enhances
Matrix Gene Expression and Synthesis in Tenocytes From Human Rotator Cuff Tendons With Degenerative
Tears. The American Journal of Sports Medicine, 40, 1035-1045.
Rat Bone Marrow Stromal Cells
Joiner,D.M., Tayim,R.J., Kadado,A. and Goldstein,S.A. Bone marrow stromal cells from aged male rats have delayed
mineralization and reduced response to mechanical stimulation through nitric oxide and ERK1/2 signaling
during osteogenic differentiation. Biogerontology, 13, 467 - 478.
Murine Lung Tissue
Jonasson,S., Koch,B. and Bucht,A. (2012) Inhalation of chlorine causes long-standing lung inflammation and airway
hyperresponsiveness in a murine model of chemical-induced lung injury. Toxicology 303, 34 – 42.
Murine Lung Tissue
Jones,C.P., Gregory,L.G., Causton,B., Campbell,G.A. and Lloyd,C.M. (2012) Activin A and TGF-β promote TH9
cellmediated pulmonary allergic pathology. Journal of Allergy and Clinical Immunology, 129, 1000 –
1010.e3.
Murine Lung and Skin
Jun,J.B., Kim,J.K., Na,Y.I., Han,H., Paik,S.S., Kim,S.H. and Kim,Y.H. (2012) Dietary Flavonoid Apigenin is not
Effective in Preventing Development of a Bleomycin-Induced Murine Model of Scleroderma. Journal of
Rheumatic Diseases, 19, 206-211.
Decellularised Sheep Liver
Kajbafzadeh,A.M., Javan-Farazmand,N., Monajemzadeh,M. and Baghayee,A. (2012) Determining the Optimal
Decellularization and Sterilization Protocol for Preparing a Tissue Scaffold of a Human-sized Liver Tissue.
Tissue Engineering, doi: 10.1089/ten.TEC.2012.0334.
Murine Lung
Kang,M.J., Choi,J.M., Kim,B.H., Lee,C.M., Cho,W.K., Choe,G., Kim,D.H., Lee,C.G. and Elias,J.A. (2012) IL-18
Induces Emphysema, and Airway and Vascular Remodeling via IFN-γ, IL-17A and IL-13. American Journal of
Respiratory and Critical Care Medicine, 185, 1205 - 1217.
Human Prostate Cancer Cell Line PC-3
Kapinas,K., Lowther,K.M., Kessler,C.B., Tilbury,K., Lieberman,J.R., Tirnauer,J.S., Campagnola,P. and Delany,A.M.
(2012) Bone matrix osteonectin limits prostate cancer cell growth and survival. Matrix Biology 31, 299 –
307.
Bronchoalveolar Lavage Fluid
Karmouty-Quintana,H., Zhong,H., Acero,L., Weng,T., Melicoff,E., West,J.D., Hemnes,A., Grenz,A., Eltzschig,H.K.
and Blackwell,T.S. (2012) The A2B adenosine receptor modulates pulmonary hypertension associated with
interstitial lung disease. The FASEB Journal, 26, 2546-2557.
Murine Lung
Kass,D.J., Yu,G., Loh,K.S., Savir,A., Borczuk,A., Kahloon,R., Juan Guardela,B., Deiuliis,G., Tedrow,J. and Choi,J.
(2012) Cytokine-Like Factor 1 Gene Expression Is Enriched in Idiopathic Pulmonary Fibrosis and Drives the
Accumulation of CD4+ T Cells in Murine Lungs: Evidence for an Antifibrotic Role in Bleomycin Injury. The
American journal of pathology, 180, 1963 – 1978.
Lung And Cardiovascular Tissue
Katwa,P., Wang,X., Urankar,R.N., Podila,R., Hilderbrand,S.C., Fick,R.B., Rao,A.M., Ke,P.C., Wingard,C.J. and
Brown,J.M. (2012) A Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL33/ST2 Axis. Small
8, 2904 – 2912.
Murine Skin
Kavian,N., Marut,W., Servettaz,A., Laude,H., Nicco,C., Ch+®reau,C., Weill,B. and Batteux,F. (2012) Arsenic
Trioxide Prevents Murine Sclerodermatous Graft-versus-Host Disease. The Journal of Immunology, 188,
5142-5149.
Kavian,N., Marut,W., Servettaz,A., Nicco,C., Chéreau,C., Lemaréchal,H., Borderie,D., Dupin,N., Weill,B. and
Batteux,F. (2012) ROSmediated killing of activated fibroblasts by arsenic trioxide ameliorates fibrosis in a
murine model of SSc. Arthritis & Rheumatism 64, 3430 - 3440.
Kavian,N., Servettaz,A., Marut,W., Nicco,C., Chéreau,C., Weill,B. and Batteux,F. (2012) Sunitinib inhibits the
phosphorylation of plateletderived growth factor receptor β in the skin of mice with sclerodermalike
features and prevents the development of the disease. Arthritis & Rheumatism, 64, 1990-2000.
Human Marrow Derived Stromal Cells
Khan,M.R., Donos,N., Salih,V. and Brett,P.M. (2012) The enhanced modulation of key bone matrix components by
modified Titanium implant surfaces. Bone 50, 1 – 8.
Human Adipose Tissue
Kim,B.S., Choi,J.S., Kim,J.D., Yoon,H.I., Choi,Y.C. and Cho,Y.W. (2012) Human collagen isolated from adipose
tissue. Biotechnology Progress 28, 973 - 980.
Murine Lung
Kinjo,T., Tomaru,K., Haines,D.C. and Klinman,D.M. (2012) The counter regulatory response induced by CpG
oligonucleotides prevents bleomycin induced pneumopathy. Respiratory Research, 13, 47.
Rat Lung
Kma,L., Gao,F., Fish,B.L., Moulder,J.E., Jacobs,E.R. and Medhora,M. (2012) Angiotensin Converting Enzyme
Inhibitors Mitigate Collagen Synthesis Induced by a Single Dose of Radiation to the Whole Thorax. Journal of
Radiation Research, 53, 10-17.
Human Hepatic Stellate Cells
Knight,V., Tchongue,J., Lourensz,D., Tipping,P. and Sievert,W. (2012) Proteaseactivated receptor 2 promotes
experimental liver fibrosis in mice and activates human hepatic stellate cells. Hepatology 55, 879 – 887.
Porcine Skin
Kono,A., Oguri,A., Yokoo,K. and Watanabe,H. (2012) YAG laser treatment causes rapid degeneration and
regeneration of collagen fibres in pig skin and facilitates fibroblast growth. Journal of Plastic Surgery and
Hand Surgery, 46, 308-312.
Rat Hepatic Stellate Cells and LX-2, a Human HSC Cell Line
Kuo,J.J., Wang,C.Y., Lee,T.F., Huang,Y.T. and Lin,Y.L. (2012) Paeoniae Radix Reduces PDGF-Stimulated Hepatic
Stellate Cell Migration. Planta medica, 78, 341 – 348.
Human Lung Tissue
Lagares,D., Busnadiego,O., GarcíaFernández,R.A., Kapoor,M., Liu,S., Carter,D.E., Abraham,D., ShiWen,X.,
Carreira,P. and Fontaine,B.A. (2012) Inhibition of focal adhesion kinase prevents experimental lung fibrosis
and myofibroblast formation. Arthritis & Rheumatism, 64, 1653-1664.
Murine Lung
Lee,C.G., Herzog,E.L., Ahangari,F., Zhou,Y., Gulati,M., Lee,C.M., Peng,X., Feghali-Bostwick,C., Jimenez,S.A. and
Varga,J. (2012) Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial
Lung Disease That Augments TGF-β1 Signaling. The Journal of Immunology, 189, 2635-2644.
Lee,H. and Park,I.H. (2012) 239 Berberine Inhibits Myofibroblast Differentiation in Nasal Polyp-derived Fibroblast via
P-38 Pathway. World Allergy Organization Journal, 5, S78.
Rat Heart Tissue
Lee,J.E., Yi,C., Jeon,B.T., Shin,H.J., Kim,S.K., Jung,T.S., Choi,J.Y. and Roh,G.S. (2012) Alpha-lipoic acid
attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats. Cardiovascular Diabetology, 11,
111.
Bone Marrow Mesenchymal Stem Cells
Lin,B.N., Whu,S.W., Chen,C.H., Hsu,F.Y., Chen,J.C., Liu,H.W., Chen,C.H. and Liou,H.M. (2012) Bone marrow
mesenchymal stem cells, plateletrich plasma and nanohydroxyapatitetype I collagen beads were integral
parts of biomimetic bone substitutes for bone regeneration. Journal of Tissue Engineering and Regenerative
Medicine, doi: 10.1002/term.1472.
Murine Lung
Li,L.F., Chu,P.H., Hung,C.Y., Kao,W.Y., Lin,M.C., Liu,Y.Y. and Yang,C.T. (2012) Lumican Regulates VentilationInduced Epithelial-Mesenchymal Transition through Extracelluar Signal-Regulated Kinase Pathway. CHEST
Journal, doi: 10.1378/chest.12-3058.
Murine Heart and Cardiac Fibroblasts
Liang,H., Zhang,C., Ban,T., Liu,Y., Mei,L., Piao,X., Zhao,D., Lu,Y., Chu,W. and Yang,B. (2012) A novel reciprocal
loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis. The International Journal of
Biochemistry & Cell Biology 44, 2152 – 2160.
Rabbit Cranial Cruciate Ligaments
Light,V.A., Montgomery,R.D. and Akingbemi,B.T. (2012) Sex hormone regulation of collagen concentrations in
cranial cruciate ligaments of sexually immature male rabbits. American Journal of Veterinary Research, 73,
1186-1193.
Fibroblast Cells (L929)
Lin,H.Y., Chen,H.H., Chang,S.H. and Ni,T.S. (2012) Pectin-chitosan-PVA nanofibrous scaffold made by
electrospinning and its potential use as a skin tissue scaffold, doi: 10.1080/09205063.2012.693047.
Murine Lung
Lin,L.J., Lin,C.C., Wang,S.D., Chao,Y.P. and Kao,S.T. (2012) The Immunomodulatory Effect of You-Gui-Wan on
Dermatogoides-pteronyssinus-Induced Asthma. Evidence-Based Complementary and Alternative Medicine,
doi: 10.1155/2012/476060.
Lin,S.J., Lu,H.K., Lee,H.W., Chen,Y.C., Li,C.L. and Wang,L.F. (2012) Nitric oxide inhibits androgen
receptormediated collagen production in human gingival fibroblasts. Journal of Periodontal Research, doi:
47, 701 - 710.
Murine Adult Fibroblasts/Smooth Muscle
Liu,S. and Leask,A. (2012) Integrin β1 is required for maintenance of vascular tone in postnatal mice. Journal of
cell communication and signaling, 6, 175 - 180.
Murine Lung Tissue
MacKinnon,A.C., Gibbons,M.A., Farnworth,S.L., Leffler,H., Nilsson,U.J., Delaine,T., Simpson,A.J., Forbes,S.J.,
Hirani,N. and Gauldie,J. (2012) Regulation of TGF-β1 Driven Lung Fibrosis by Galectin-3. American Journal
of Respiratory and Critical Care Medicine, 185, 537-546.
Murine Intestine
Månsson,L.E., Montero,M., Zarepour,M., Bergstrom,K.S., Ma,C., Huang,T., Man,C., Grassl,G.A. and Vallance,B.A.
(2012) MyD88 signaling promotes both mucosal homeostatic and fibrotic responses during Salmonellainduced colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303, G311-G323.
Meniscus Cell/Articular Chondrocyte Co-Culture
MacBarb,R.F., Makris,E.A., Hu,J.C. and Athanasiou,K.A. (2012) A chondroitinase-ABC and TGF-β1 treatment regimen
for enhancing the mechanical properties of tissue engineered fibrocartilage. Acta Biomaterialia 9, 4626 –
4634.
Rat Lung
Mahmood,J., Jelveh,S., Zaidi,A., Doctrow,S.R. and Hill,R.P. (2012) Mitigation of Radiation-Induced Lung Injury with
EUK-207 and Genistein: Effects in Adolescent Rats. Radiation Research,
http://dx.doi.org/10.1667/RR2954.1.
Murine Skin and Lungs
Marut,W.K., Kavian,N., Servettaz,A., Nicco,C., Ba,L.A., Doering,M., Chéreau,C., Jacob,C., Weill,B. and Batteux,F.
(2012) The Organotelluride Catalyst (PHTE)2NQ Prevents HOCl-Induced Systemic Sclerosis in Mouse. Journal
of Investigative Dermatology, 132, 1125 – 1132.
Brain and Spinal Cord ECM Scaffolds
Medberry,C.J., Crapo,P.M., Siu,B.F., Carruthers,C.A., Wolf,M.T., Nagarkar,S.P., Agrawal,V., Jones,K.E., Kelly,J.
and Johnson,S.A. (2012) Hydrogels derived from central nervous system extracellular matrix. Biomaterials
34, 1033 – 1040.
Mendoza,C., Jiménez,A.V., Rangel,C., Lozano,A., Morales,V., Becerril,C., Chavira,R., Ruiz,V., Barrera,L. and
Montaño,M. (2012) DHEA has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis.
European Respiratory Journal, doi: 10.1183/0903/936.00027412.
Human Adipose Tissue-Derived MSCs
Merceron,C., Portron,S., VignesColombeix,C., Rederstorff,E., Masson,M., Lesoeur,J., Sourice,S., Sinquin,C.,
ColliecJouault,S. and Weiss,P. (2012) Pharmacological Modulation of Human Mesenchymal Stem Cell
Chondrogenesis by a Chemically Oversulfated Polysaccharide of Marine Origin: Potential Application to
Cartilage Regenerative Medicine. Stem Cells, 30, 471-480.
Human Lung Tissue
Milara,J., Navarro,R., Juan,G., Peiró,T., Serrano,A., Ramón,M., Morcillo,E. and Cortijo,J. (2012) Sphingosine-1phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to
mesenchymal transition. Thorax, 67, 147-156.
Human Tenocytes
Millar,N.L., Reilly,J.H., Kerr,S.C., Campbell,A.L., Little,K.J., Leach,W.J., Rooney,B.P., Murrell,G.A.C. and
McInnes,I.B. (2012) Hypoxia: a critical regulator of early human tendinopathy. Annals of the Rheumatic
Diseases, 71, 302-310.
Human Lung Fibroblast Cells
Mishra,A., Rojanasakul,Y., Chen,B.T., Castranova,V., Mercer,R.R. and Wang,L. (2012) Assessment of Pulmonary
Fibrogenic Potential of Multiwalled Carbon Nanotubes in Human Lung Cells. Journal of Nanomaterials, doi:
10.1155/2012/930931.
Human Retinoblastoma (RB) Cell Line Y79
Mitra,M., Mohanty,C., Harilal,A., Maheswari,U.K., Sahoo,S.K. and Krishnakumar,S. (2012) A novel in vitro threedimensional retinoblastoma model for evaluating chemotherapeutic drugs. Molecular Vision, 18, 1361.
Rat Lung Tissue
Miyake,K., Tani,K., Kakiuchi,S., Suzuka,C., Toyoda,Y., Kishi,J., Tezuka,T., Yuasa,S., Hanibuchi,M. and Aono,Y.
(2012) Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but
attenuates lung fibrosis in response to radiation injury in rats. The Journal of Medical Investigation, 59,
175.
Murine Lung
Miyoshi,K., Yanagi,S., Kawahara,K., Nishio,M., Tsubouchi,H., Imazu,Y., Koshida,R., Matsumoto,N., Taguchi,A. and
Yamashita,S. (2012) Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial
Cell Integrity. American journal of respiratory and critical care medicine, doi: 10.1164/rccm.20120508510c.
Rat Dermal Wound
Mohanty,C., Das,M. and Sahoo,S.K. (2012) Sustained Wound Healing Activity of Curcumin Loaded Oleic Acid Based
Polymeric Bandage in a Rat Model. Molecular Pharmaceutics 9, 2801 – 2811.
Human Skin Biopsies
Moinzadeh,P., Denton,C.P., Abraham,D., Ong,V., Hunzelmann,N., Eckes,B. and Krieg,T. (2012) Biomarkers for skin
involvement and fibrotic activity in scleroderma. Journal of the European Academy of Dermatology and
Venereology 26, 267 – 276.
Normal Human Lung Fibroblasts
Montes,E., Ruiz,V., Checa,M., Maldonado,V., Melendez-Zajgla,J., Montaño,M., Ordoñez-Razo,R., Cisneros,J.,
García-de-Alba,C. and Pardo,A. (2012) Renin is an angiotensin-independent profibrotic mediator: role in
pulmonary fibrosis. European Respiratory Journal, 39, 141-148.
Normal Human Lung Fibroblasts
Montes,E., Ruiz,V., Checa,M., Maldonado,V., Zajgla,J.M., Montaño,M., Razo,R.O., Cisneros,J., García-de-Alba,C.
and Pardo,A. (2012) Renin is an angiotensin-independent profibrotic mediator. Role in pulmonary fibrosis.
European Respiratory Journal, 39, 141-148.
Scaffold Seeded with Rat Bone Marrow Stromal Cells
Muhammad,K.B., Abas,W.A.B.W., Kim,K.H., Pingguan-Murphy,B., Zain,N.M. and Akram,H. (2012) In vitro
comparative study of white and dark polycaprolactone trifumarate in situ cross-linkable scaffolds seeded
with rat bone marrow stromal cells. Clinics, 67, 629.
Bovine Chondrocytes
Mujeeb,A., Miller,A.F., Saiani,A. and Gough,J.E. (2012) Self-assembled octapeptide scaffolds for in vitro
chondrocyte culture. Acta Biomaterialia 9, 4609 – 4617.
Murine Lung
Murray,A.R., Kisin,E.R., Tkach,A.V., Yanamala,N., Mercer,R., Young,S.H., Fadeel,B., Kagan,V.E. and Shvedova,A.A.
(2012) Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity
versus asbestos. Particle and Fibre Toxicology, 9, 10.
Alveolar Septa
Ohta,H., Chiba,S., Ebina,M., Furuse,M. and Nukiwa,T. (2012) Altered expression of tight junction molecules in
alveolar septa in lung injury and fibrosis. American Journal of Physiology-Lung Cellular and Molecular
Physiology, 302, L193-L205.
A Skin Fibroblast Cell Line
Okamoto,Y., Hasegawa,M., Matsushita,T., Hamaguchi,Y., Huu,D.L., Iwakura,Y., Fujimoto,M. and Takehara,K.
(2012) Potential roles of interleukin 17A in the development of skin fibrosis. Arthritis & Rheumatism 64,
3726 – 3735.
Primary Rat Osteoblasts
Orriss,I.R., Key,M.L., Brandao-Burch,A., Patel,J.J., Burnstock,G. and Arnett,T.R. (2012) The regulation of
osteoblast function and bone mineralisation by extracellular nucleotides: The role of p2x receptors. Bone,
51, 389 – 400.
Oyoshi,M.K., He,R., Kanaoka,Y., ElKhal,A., Kawamoto,S., Lewis,C.N., Austen,K.F. and Geha,R.S. (2012) Eosinophilderived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse
model of atopic dermatitis. Proceedings of the National Academy of Sciences, 109, 4992-4997.
Murine Colon
Oz,H.S., Zhong,J. and de Villiers,W.J.S. (2012) Osteopontin ablation attenuates progression of colitis in TNBS
model. Digestive diseases and sciences, 57, 1554 - 1561.
Human Renal Mesangial Cells
Paccosi,S., Musilli,C., Mangano,G., Guglielmotti,A. and Parenti,A. (2012) The monocyte chemotactic protein
synthesis inhibitor bindarit prevents mesangial cell proliferation and extracellular matrix remodeling.
Pharmacological Research 66, 526 – 535.
Cardiomyocytes
Panse,K.D., Felkin,L.E., López-Olañeta,M.M., Gómez-Salinero,J., Villalba,M., Muñoz,L., Nakamura,K., Shimano,M.,
Walsh,K. and Barton,P.J.R. (2012) Follistatin-Like 3 Mediates Paracrine Fibroblast Activation by
Cardiomyocytes. Journal of Cardiovascular Translational Research, 5, 814 – 826.
Murine Lung and Lung Fibroblasts
Park,C.S., Bang,B.R., Kwon,H.S., Moon,K.A., Kim,T.B., Lee,K.Y., Moon,H.B. and Cho,Y.S. (2012) Metformin reduces
airway inflammation and remodeling via activation of AMP-activated protein kinase. Biochemical
Pharmacology 84, 1660 – 1670.
Park,I.H. and Lee,H. (2012) 153 Effect of Simvastatin on Transforming Growth Factor BETA-1-Induced Myofibroblast
Differentiation and Collagen Production in Nasal Polyp-Derived Fibroblasts. World Allergy Organization
Journal, 5, S51.
Park,I.H., Park,S.J., Cho,J.S., Moon,Y.M., Moon,J.H., Kim,T.H., Lee,S.H. and Lee,H.M. (2012) Effect of simvastatin
on transforming growth factor beta-1-induced myofibroblast differentiation and collagen production in nasal
polyp-derived fibroblasts. American Journal of Rhinology & Allergy, 26, 7-11.
Park,I.H., Park,S.J., Cho,J.S., Moon,Y.M., Kim,T.H., Lee,S.H. and Lee,H.M. (2012) Role of Reactive Oxygen Species
in Transforming Growth Factor Beta1-Induced Alpha Smooth-Muscle Actin and Collagen Production in Nasal
Polyp-Derived Fibroblasts. International Archives of Allergy and Immunology, 159, 278 – 286.
Porcine Liver
Park,K.M., Park,S.M., Yang,S.R., Hong,S.H. and Woo,H.M. (2012) Preparation of immunogen-reduced and
biocompatible extracellular matrices from porcine liver. Journal of Bioscience and Bioengineering 115, 207
– 215.
Park,S.A., Park,I.H., Cho,J.S., Moon,Y.M., Lee,S.H., Kim,T.H., Lee,S.H. and Lee,H.M. (2012) Effect of [6]-gingerol
on myofibroblast differentiation in transforming growth factor beta 1-induced nasal polyp-derived
fibroblasts. American Journal of Rhinology & Allergy, 26, 97-103.
Murine Lung
Park,S.J., Lee,K.S., Lee,S.J., Kim,S.R., Park,S.Y., Jeon,M.S., Lee,H.B. and Lee,Y.C. (2012) l-2-Oxothiazolidine-4Carboxylic Acid or α-Lipoic Acid Attenuates Airway Remodeling: Involvement of Nuclear Factor-κ(NF-κB),
Nuclear Factor Erythroid 2p45-Related Factor-2 (Nrf2), and Hypoxia-Inducible Factor (HIF). International
Journal of Molecular Sciences, 13, 7915-7937.
Rat Cervical Tissue
Poellmann,M.J., Chien,E.K., McFarlin,B.L. and Johnson,A.J.W. (2012) Mechanical and structural changes of the rat
cervix in late-stage pregnancy. Journal of the Mechanical Behavior of Biomedical Materials 17, 66 – 75.
Murine MLO-A5 Pre-Osteocyte Cell Line
Prideaux,M., Loveridge,N., Pitsillides,A.A. and Farquharson,C. (2012) Extracellular Matrix Mineralization Promotes
E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation. PloS one, 7, e36786.
Murine Lung
Qin,X.J., Zhang,G.S., Zhang,X., Qiu,Z.W., Wang,P.L., Li,Y.W., Li,W., Xie,Q.M., Ke,Y.H. and Lee,J.J. (2012) Protein
tyrosine phosphatase SHP2 regulates TGFβ1 production in airway epithelia and asthmatic airway
remodeling in mice. Allergy 67, 1547 – 1556.
Re-em,T., Witte,F., Willbold,E., Ruvinov,E. and Cohen,S. (2012) Simultaneous regeneration of articular cartilage
and subchondral bone induced by spatially-presented TGF-beta and BMP-4 in a bi-layer affinity binding
system. Acta Biomaterialia, 8, 3283 - 3293.
Murine Systemic Sclerosis Fibroblasts
Reich,N., Tomcik,M., Zerr,P., Lang,V., Dees,C., Avouac,J., Palumbo,K., Horn,A., Akhmetshina,A. and Beyer,C.
(2012) Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal
fibrosis. Annals of the Rheumatic Diseases, 71, 737 - 745.
Rat Liver
Ricci,E., Vanosi,G., Lindenmair,A., Hennerbichler,S., Peterbauer-Scherb,A., Wolbank,S., Cargnoni,A.,
Signoroni,P.B., Campagnol,M. and Gabriel,C. (2012) Anti-fibrotic effects of fresh and cryopreserved human
amniotic membrane in a rat liver fibrosis model. Cell and Tissue Banking, doi: 10.1007/s10561-012-9337-x.
Rat Aorta
Roan,J.N., Tsai,Y.C., Chen,I.W., Chang,S.W., Huang,C.C. and Lam,C.F. (2012) Inhibition of cyclooxygenase-2
modulates phenotypic switching of vascular smooth muscle cells during increased aortic blood flow. Heart
and vessels, 27, 307 - 315.
Murine Lung Tissue
Rey-Parra,G.J., Vadivel,A., Coltan,L., Hall,A., Eaton,F., Schuster,M., Loibner,H., Penninger,J.M., Kassiri,Z. and
Oudit,G.Y. (2012) Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. Journal of
Molecular Medicine, 90, 637 – 647.
Rat Lung Tissue
Roberts,J.R., Mercer,R.R., Chapman,R.S., Cohen,G.M., Bangsaruntip,S., Schwegler-Berry,D., Scabilloni,J.F.,
Castranova,V., Antonini,J.M. and Leonard,S.S. (2012) Pulmonary Toxicity, Distribution, and Clearance of
Intratracheally Instilled Silicon Nanowires in Rats. Journal of Nanomaterials, doi: 10.1155/2012/398302.
Murine Lung Tissue
Ronzani,C., Spiegelhalter,C., Vonesch,J.L., Lebeau,L. and Pons,F. (2012) Lung deposition and toxicological
responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse.
Archives of toxicology, 86, 137 - 149.
Human Mesenchymal Stromal Cells
Sadr,N., Pippenger,B.E., Scherberich,A., Wendt,D., Mantero,S., Martin,I. and Papadimitropoulos,A. (2012)
Enhancing the biological performance of synthetic polymeric materials by decoration with engineered,
decellularized extracellular matrix. Biomaterials, 33, 5085 – 5093.
Pancreatic Stellate Cells
Saito,R., Yamada,S., Yamamoto,Y., Kodera,T., Hara,A., Tanaka,Y., Kimura,F., Takei,I., Umezawa,K. and Kojima,I.
(2012) Conophylline Suppresses Pancreatic Stellate Cells and Improves Islet Fibrosis in Goto-Kakizaki Rats.
Endocrinology, 153, 621-630.
Lung Tissue
Sakamoto,K., Hashimoto,N., Kondoh,Y., Imaizumi,K., Aoyama,D., Kohnoh,T., Kusunose,M., Kimura,M., Kawabe,T.
and Taniguchi,H. (2012) Differential modulation of surfactant protein D under acute and persistent hypoxia
in acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology, 303, L43-L53.
Rat Pancreatic Stellate Cells
Saito,R., Yamada,S., Yamamoto,Y., Kodera,T., Hara,A., Tanaka,Y., Kimura,F., Takei,I., Umezawa,K. and Kojima,I.
(2012) Conophylline Suppresses Pancreatic Stellate Cells and Improves Islet Fibrosis in Goto-Kakizaki Rats.
Endocrinology, 153, 621-630.
Murine Bronchoalveolar (BAL) Lavage Fluid
Schneider,D.J., Wu,M., Le,T.T., Cho,S.H., Brenner,M.B., Blackburn,M.R. and Agarwal,S.K. (2012) Cadherin-11
contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal
transition. The FASEB Journal, 26, 503-512.
Murine Lung
Serra,M.F., Anjos-Valotta,E.A., Olsen,P.C., Couto,G.C., Jurgilas,P.B., Cotias,A.C., Pão,C.R., Ferreira,T.P.T.,
Arantes,A.C.S. and Pires,A.L.A. (2012) Nebulized Lidocaine Prevents Airway Inflammation, Peribronchial
Fibrosis, and Mucus Production in a Murine Model of Asthma. Anesthesiology, 117, 580-591.
Osteoblasts
Shainberg,A.P.M., Valério,P., Zonari,A., Oktar,F.N., Ozyegin,L.S., Leite,M.F. and Goes,A.M. (2012) Attachment and
Proliferation of Osteoblasts on Lithium-Hydroxyapatite Composites. Advances in Materials Science and
Engineering, doi: 10.1155/2012/650574.
Induced Pluripotent Stem Cell- and Human Embryonic Stem Cell-Derived Fibroblasts
Shamis,Y., Hewitt,K.J., Bear,S.E., Alt-Holland,A., Qari,H., Margvelashvilli,M., Knight,E.B., Smith,A. and
Garlick,J.A. (2012) iPSC-derived fibroblasts demonstrate augmented production and assembly of
extracellular matrix proteins. In Vitro Cellular & Developmental Biology-Animal, 48, 112 - 122.
Shao,L., Wang,Q. and Dong,Y. (2012) Repetitive mechanical stretching modulates transforming growth factorinduced collagen synthesis and apoptosis in human patellar tendon fibroblasts. Biochemistry and Cell
Biology, 90, 667-674.
Murine Lung
Shvedova,A.A., Kapralov,A.A., Feng,W.H., Kisin,E.R., Murray,A.R., Mercer,R.R., Croix,C.M.S., Lang,M.A.,
Watkins,S.C. and Konduru,N.V. (2012) Impaired clearance and enhanced pulmonary inflammatory/fibrotic
response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS One, 7, e30923.
Fibroblasts
Smith,A.M., Hunt,N.C., Shelton,R.M., Birdi,G. and Grover,L.M. (2012) Alginate hydrogel has a negative impact on in
vitro collagen 1 deposition by fibroblasts. Biomacromolecules 13, 4032 – 4038.
Biodegradable Collagen Films
Sommer,I. and Kunz,P.M. Improving the water resistance of biodegradable collagen films. Journal of Applied
Polymer Science, 125, E27 – E41.
Murine Kidney
Sugiyama,N., Kohno,M. and Yokoyama,T. (2012) Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an
NPHP2 mouse model. Nephrology Dialysis Transplantation, 27, 1351-1358.
Porcine Kidney
Sullivan,D.C., Mirmalek-Sani,S.H., Deegan,D.B., Baptista,P.M., Aboushwareb,T., Atala,A. and Yoo,J.J. (2012)
Decellularization methods of porcine kidneys for whole organ engineering using a high-throughput system.
Biomaterials 33, 7756 – 7764.
Osteoblasts
Syberg,S., BrandaoBurch,A., Patel,J.J., Hajjawi,M., Arnett,T.R., Schwarz,P., Jorgensen,N.R. and Orriss,I.R. (2012)
Clopidogrel (Plavix), a P2Y12 receptor antagonist, inhibits bone cell function in vitro and decreases
trabecular bone in vivo. Journal of Bone and Mineral Research 27, 2373 – 2386.
Human Vaginal Smooth
Muscle Cells
Takacs,P., Zhang,Y., Candiotti,K., Jaramillo,S. and Medina,C.A. (2012) Effects of PPAR-delta agonist and zinc on
vaginal smooth muscle cells collagen and tropoelastin production. International Urogynecology Journal, 23,
1775 - 1779.
Murine Lung Tissue
Takemasa,A., Ishii,Y. and Fukuda,T. (2012) A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary
fibrosis in mice. European Respiratory Journal, doi: 10.1183/09031936.
Human Bone Marrow-Derived Mesenchymal Stem Cells (hMSCs)
Tan,S.L., Ahmad,R.E., Ahmad,T.S., Merican,A.M., Abbas,A.A., Ng,W.M. and Kamarul,T. (2012) Effect of Growth
Differentiation Factor 5 on the Proliferation and Tenogenic Differentiation Potential of Human Mesenchymal
Stem Cells in vitro. Cells Tissues Organs, 196, 325 - 338.
Smooth Muscle Cells
Thomas,L.V. and Nair,P.D. (2012) Influence of Mechanical Stimulation in the Development of a Medial Equivalent
Tissue-Engineered Vascular Construct using a Gelatin-g-Vinyl Acetate Co-Polymer Scaffold. Journal of
Biomaterials Science, Polymer Edition, 23, 2069-2087.
Murine Colon Tissue
Thoua,N.M.,Derrett-Smith,E.C., Khan,K., Dooley,A., Shi-Wen,X. and Denton,C.P. (2012) Gut fibrosis with altered
colonic contractility in a mouse model of scleroderma. Rheumatology doi: 10.1093/rheumatology/kes191.
Murine Embryo Lung
Tiozzo,C., Carraro,G., Al Alam,D., Baptista,S., Danopoulos,S., Li,A., Lavarreda-Pearce,M., Li,C., De Langhe,S. and
Chan,B. (2012) Mesodermal Pten inactivation leads to alveolar capillary dysplasia-like phenotype. The
Journal of Clinical Investigation, 122, 3862.
Rat Small Intestine
Totonelli,G., Maghsoudlou,P., Garriboli,M., Riegler,J., Orlando,G., Burns,A.J., Sebire,N.J., Smith,V.V.,
Fishman,J.M. and Ghionzoli,M. (2012) A rat decellularized small bowel scaffold that preserves villus-crypt
architecture for intestinal regeneration. Biomaterials 33, 3401 – 3410.
Human Tenocytes
Tucker,R. (2012) Validated Cyclic Shear Stress Significantly Up-Regulates ECM Secretion By Human Tenocytes.
Journal of Biomechanics, 45, S437.
Human Alveolar Periosteal Sheets
Uematsu,K., Kawase,T., Nagata,M., Suzuki,K., Okuda,K., Yoshie,H., Burns,D.M. and Takagi,R. (2012) Tissue culture
of human alveolar periosteal sheets using a stem-cell culture medium (MesenPRO-RS): In vitro expansion
of CD146-positive cells and concomitant upregulation of osteogenic potential in vivo. Stem Cell Research
10, 1 – 19.
Rat Cardiac Cells (H9C2(2-1))
Umadevi,S., Gopi,V., Simna,S.P., Parthasarathy,A., Yousuf,S.M.J. and Elangovan,V. (2012) Studies on the Cardio
Protective Role of Gallic Acid Against AGE-Induced Cell Proliferation and Oxidative Stress in H9C2 (2-1)
Cells. Cardiovascular Toxicology, 12, 304 - 311.
Rodent Unilateral Ureteral Obstruction Model
Veerappan,A., Reid,A.C., O'Connor,N., Mora,R., Brazin,J.A., Estaphan,R., Kameue,T., Chen,J., Felsen,D. and
Seshan,S. (2012) Mast Cells are Required for the Development of Renal Fibrosis in the Rodent Unilateral
Ureteral Obstruction Model. American Journal of Physiology-Renal Physiology 302, F192 - 204.
Human Adipose-Derived Stem Cells
Wang,C., Guo,f.f., Zhou,H., Zhang,Y., Xiao,Z. and Cui,L. (2012) Proteomic profiling of tissue-engineered blood
vessel walls constructed by adipose-derived stem cells. Tissue Engineering 19, 415 – 425.
Murine Lung Tissue
Wang,S.D., Lin,L.J., Chen,C.L., Lee,S.C., Lin,C.C., Wang,J.Y. and Kao,S.T. (2012) Xiao-Qing-Long-Tang attenuates
allergic airway inflammation and remodeling in repetitive Dermatogoides pteronyssinus challenged chronic
asthmatic mice model. Journal of Ethnopharmacology 142, 531 – 538.
Bovine Corneal Endothelial Cells
Wang,T.J., Wang,I., Chen,Y.H., Lu,J.N. and Young,T.H. (2012) Polyvinylidene fluoride for proliferation and
preservation of bovine corneal endothelial cells by enhancing type IV collagen production and deposition.
Journal of Biomedical Materials Research Part A 100A, 252 – 260.
Lung Tissue
Wang,X., Xia,T., Duch,M.C., Ji,Z., Zhang,H., Li,R., Sun,B., Lin,S., Meng,H. and Liao,Y.P. (2012) Pluronic F108
Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury.
Nano Letters 12, 3050 – 3061.
Wen,K.C., Fan,P.C., Tsai,S.Y., Shih,I. and Chiang,H.M. (2012) Ixora parviflora Protects against UVB-Induced
Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I
Procollagen Synthesis. Evidence-Based Complementary and Alternative Medicine, doi:
10.1155/2012/417346.
Murine Lung Tissue
Wigenstam,E., Jonasson,S., Koch,B. and Bucht,A. (2012) Corticosteroid treatment inhibits airway
hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation.
Toxicology 301, 66 – 71.
Human Smooth Muscle and Mesenchymal Stem Cells
Williams,C., Xie,A.W., Emani,S., Yamato,M., Okano,T., Emani,S.M. and Wong,J.Y. (2012) A Comparison of Human
Smooth Muscle and Mesenchymal Stem Cells as Potential Cell Sources for Tissue-Engineered Vascular
Patches. Tissue Engineering Part A, 18, 986 – 998.
Decellularised Porcine Dermis and Urinary Bladder Tissue
Wolf,M.T., Daly,K.A., Brennan-Pierce,E.P., Johnson,S.A., Carruthers,C.A., D'Amore,A., Nagarkar,S.P., Velankar,S.S.
and Badylak,S.F. (2012) A hydrogel derived from decellularized dermal extracellular matrix. Biomaterials
33, 7028 – 7038.
Murine Dermal Fibroblasts and Skin
Wu,M., Schneider,D.J., Mayes,M.D., Assassi,S., Arnett,F.C., Tan,F.K., Blackburn,M.R. and Agarwal,S.K. (2012)
Osteopontin in Systemic Sclerosis and Its Role in Dermal Fibrosis. Journal of Investigative Dermatology,
132, 1605 – 1614.
Regenerated and Native Arteries
Wu,W., Allen,R.A. and Wang,Y. (2012) Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic
graft into a neoartery. Nature Medicine 18, 1148 – 1153.
Murine Colon Cancer CT-26 Cells
Yan,X., Gardner,T.R., Grieco,M., Herath,S.A.C., Jang,J.H., Kirchoff,D., Njoh,L., Shantha Kumara,H.M.C.,
Naffouje,S. and Whelan,R.L. (2012) Perioperative polyphenon E-and siliphos-inhibited colorectal tumor
growth and metastases without impairment of gastric or abdominal wound healing in mouse models.
Surgical Endoscopy, 26, 1856 – 1864.
Cardiac Tissue
Yaniz-Galende,E., Chen,J.Q., Chemaly,E.R., Liang,L., Hulot,J.S., McCollum,L.T., Arias,T., Fuster,V., Zsebo,K. and
Hajjar,R.J. (2012) Stem Cell Factor Gene Transfer Promotes Cardiac Repair After Myocardial Infarction via
In Situ Recruitment and Expansion of c-kit+ Cells. Circulation Research doi:
10.1161/CIRCRESAHA.111.263830.
Rat Nasal Cavity and Sinus
Yeo,S.W., Bae,S.C., Kim,D.H., Jeon,E.J., Park,S.N. and Park,K.H. (2012) Effects of a TNF-α Antagonist on
Rhinosinusitis Model. Otolaryngology--Head and Neck Surgery, 147, 245-246.
Human Lung Tissue
Yasui,M., Miyazaki,Y., Mitaka,K., Ishizuka,M., Unoura,K., Tamaoka,M., Sumi,Y. and Inase,N. (2012) EpithelialMesenchymal Transition in Chronic Hypersensitivity Pneumonitis. Journal of medical and dental sciences,
59, 29-41.
Murine Lung
Young,L.R., Gulleman,P.M., Bridges,J.P., Weaver,T.E., Deutsch,G.H., Blackwell,T.S. and McCormack,F.X. (2012)
The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. American
journal of respiratory and critical care medicine, 186, 1014-1024.
Murine Lung
Zaidi,A., Jelveh,S., Mahmood,J. and Hill,R.P. (2012) Effects of lipopolysaccharide on the response of C57BL/6J mice
to whole thorax irradiation. Radiotherapy and Oncology 105, 341 – 349.
Fibroblasts
Zerr,P., Palumbo-Zerr,K., Distler,A., Tomcik,M., Vollath,S., Munoz,L.E., Beyer,C., Dees,C., Egberts,F. and
Tinazzi,I. (2012) Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic
graft-versus-host disease. Blood doi: 10.1182/blood-2012-01-403428.
Rat Dermal Wound
Zhang,Q., O’Hearn,S., Kavalukas,S.L. and Barbul,A. (2012) Role of High Mobility Group Box 1 (HMGB1) in Wound
Healing. Journal of Surgical Research, 176, 343-347.
Murine Alveolar Epithelia
Zhang,X., Zhang,Y., Tao,B., Teng,L., Li,Y., Cao,R., Gui,Q., Ye,M., Mou,X. and Cheng,H. (2012) Loss of Shp2 in
alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis.
The FASEB Journal, 26, 2338-2350.
Murine Airways
Zhao,J., Lloyd,C.M. and Noble,A. (2012) Th17 responses in chronic allergic airway inflammation abrogate regulatory
T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunology, doi:
10.1038/mi.2012.76.
Zheng,J., Lai,W., Zhu,G., Wan,M., Chen,J., Tai,Y. and Lu,C. (2012) 10Hydroxy2decenoic acid prevents
ultraviolet Ainduced damage and matrix metalloproteinases expression in human dermal fibroblasts.
Journal of the European Academy of Dermatology and Venereology doi: 10.1111/j.1468-3083.2012.04707.x.
Murine Lung and Lung Fibroblasts
Zhou,Y., Lee,J.Y., Lee,C.M., Cho,W.K., Kang,M.J., Koff,J.L., Yoon,P.O., Chae,J., Park,H.O. and Elias,J.A. (2012)
Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of
Transforming Growth Factor-β-induced Pulmonary Fibrosis. Journal of Biological Chemistry, 287, 4199142000.
Rat Auricular Cartilage Chondrocytes
Zhu,J., Cai,B., Ma,Q., Chen,F. and Wu,W. (2012) Cell bricksenriched plateletrich plasma gel for injectable
cartilage engineeringan in vivo experiment in nude mice. Journal of Tissue Engineering and Regenerative
Medicine, doi: 10.1002/term.1475.
2011
Human and Murine Left Atria
Adam,O., Theobald,K., Lavall,D., Grube,M., Kroemer,H.K., Ameling,S., Schafers,H.J., Bohm,M. and Laufs,U. (2011)
Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation. Journal of Molecular
and Cellular Cardiology, 50, 678 – 685.
Murine Lung Tissue
Ahangari,F., Takyar,S.S., Lee,C.G., Vasavada,H.H. and Elias,J.A. (2011) Chitotriosidase (Chitinase 1) Plays An
Essential Role In IL-13-Induced Inflammation, Fibrosis And Alternative (M2) Macrophage Activation.
American Journal of Respiratory and Critical Care Medicine, 183, A2868.
Murine Lung Tissue
Ahmad,T., Mabalirajan,U., Hasija,K., Ghosh,B. and Agrawal,A. (2011) Mepacrine treatment attenuates allergic
airway remodeling segregated from airway inflammation in mice. International immunopharmacology, 11,
74-78.
Bovine Tendons
Alexander,J.C., Pandit,A., Bao,G., Connolly,D. and Rochev,Y. (2011) Monitoring mRNA in living cells in a 3D in vitro
model using TAT-peptide linked molecular beacons. Lab Chip, 11, 3908 – 3914.
Allanore,Y., Saad,M., DieudéP., Avouac,J., Distler,J.H.W., Amouyel,P., Matucci-Cerinic,M., Riemekasten,G.,
Airo,P. and Melchers,I. (2011) Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci
for Systemic Sclerosis. PLoS Genetics, 7, e1002091.
Human Fetal Cardiac Fibroblasts
Alvarez,D., Briassouli,P., Clancy,R.M., Zavadil,J., Reed,J.H., Abellar,R.G., Halushka,M., Fox-Talbot,K., Barrat,F.J.
and Buyon,J.P. (2011) A Novel Role of Endothelin-1 in Linking Toll-like Receptor 7-mediated Inflammation
to Fibrosis in Congenital Heart Block. Journal of Biological Chemistry, 286, 30444-30454.
Anpo,M., Shirayama,K. and Tsutsui,T. (2011) Cytotoxic effect of eugenol on the expression of molecular markers
related to the osteogenic differentiation of human dental pulp cells. Odontology, 99, 188 – 192.
Bovine Intramuscular Fibroblasts
Archile-Contreras,A.C., Cha,M.C., Mandell,I.B., Miller,S.P. and Purslow,P.P. (2011) Vitamins E and C May Increase
Collagen Turnover by Intramuscular Fibroblasts. Potential for Improved Meat Quality. Journal of
agricultural and food chemistry 59, 608 – 614.
Rat Renal Cortical Tissue
Asanuma,H., Vanderbrink,B.A., Campbell,M.T., Hile,K.L., Zhang,H., Meldrum,D.R. and Meldrum,K.K. (2011)
Arterially delivered mesenchymal stem cells prevent obstruction-induced renal fibrosis. Journal of Surgical
Research, 168, e51-e59.
Rat Endomyocardial Samples
Ayala,P., Montenegro,J., Vivar,R., Letelier,A., Urroz,P.A., Copaja,M., Pivet,D., Humeres,C., Troncoso,R. and
Vicencio,J.M. (2011) Attenuation of endoplasmic reticulum stress using the chemical chaperone 4phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Experimental and Molecular
Pathology 92, 97 – 104.
Murine Lung Tissue
Atochina-Vasserman,E.N., Bates,S.R., Zhang,P., Abramova,H., Zhang,Z., Gonzales,L., Tao,J.Q., Gochuico,B.R.,
Gahl,W. and Guo,C.J. (2011) Early Alveolar Epithelial Dysfunction Promotes Lung Inflammation in a Mouse
Model of Hermansky Pudlak Syndrome. American Journal of Respiratory and Critical Care Medicine, 184,
449 – 458.
Porcine Aortic Valve Cusps
Balachandran,K., Hussain,S., Yap,C.H., Padala,M., Chester,A.H. and Yoganathan,A.P. (2011) Elevated cyclic stretch
and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT2A receptor-dependent
pathway. Cardiovascular Pathology, doi: 10.1016/j.carpath.2011.07.005.
Murine Cardiac Ventricular Fibroblasts
Benamer,N., Fares,N., Bois,P. and Faivre,J.F. (2011) Electrophysiological and Functional effects of sphingosine-1phosphate in mouse ventricular fibroblasts. Biochemical and Biophysical Research Communications, 408, 6
– 11.
Murine Lung Tissue
Bitencourt,C.S., Pereira,P.A.T., Ramos,S.G., Sampaio,S.V., Arantes,E.C., Aronoff,D.M. and Faccioli,L.H. (2011)
Hyaluronidase recruits mesenchymal-like cells to the lung and ameliorates fibrosis. Fibrogenesis & Tissue
Repair, 4, 3.
Murine Lung Tissue
Bogatkevich,G.S., Ludwicka Bradley,A., Nietert,P.J., Akter,T., van Ryn,J. and Silver,R.M. (2011) Antiinflammatory
and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of
interstitial lung disease. Arthritis & Rheumatism, 63, 1416-1425.
Rat Renal Fibroblasts
Boor,P., Celec,P., Martin,I.V., Villa,L., Hodosy,J., KlenovicsováK., Esposito,C., Schäfer,S., Albrecht-Küpper,B. and
Ostendorf,T. (2011) The peroxisome proliferator-activated receptor- agonist, BAY PP1, attenuates renal
fibrosis in rats. Kidney International 80, 1182 – 1197.
Human Archeological Bones
Caputo,I., Lepretti,M., Scarabino,C., Esposito,C. and Proto,A. (2011) An acetic acid-based extraction method to
obtain high quality collagen from archeological bone remains. Analytical Biochemistry,
http://dx.doi.org/10.1016/j.ab.2011.10.024.
Human Lung Tissue
Carnesecchi,S., Deffert,C., Donati,Y., Basset,O., Hinz,B., Preynat-Seauve,O., Guichard,C., Arbiser,J.L., Banfi,B.
and Pache,J.C. (2011) A key role for NOX4 in epithelial cell death during development of lung fibrosis.
Antioxidants & Redox Signaling 15, 607 – 619.
Murine Lung Tissue
Chen,C.M., Wu,M.Y., Chou,H.C., Lang,Y.D. and Wang,L.F. (2011) Downregulation of Caveolin-1 in a Murine Model of
Acute Allergic Airway Disease. Pediatrics & Neonatology, 52, 5 – 10.
Human Fibroblasts
Chiang,H.M., Lin,T.J., Chiu,C.Y., Chang,C.W., Hsu,K.C., Fan,P.C. and Wen,K.C. (2011) Coffea Arabica extract and
its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway. Food and
Chemical Toxicology, 49, 309-318.
Human Adipose Tissue Stem Cells
Choi,J.S., Kim,B.S., Kim,J.D., Choi,Y.C., Lee,H.Y. and Cho,Y.W. (2011) In Vitro Cartilage Tissue Engineering Using
Adipose-Derived Extracellular Matrix Scaffolds Seeded with Adipose-Derived Stem Cells. Tissue Engineering
Part A, 18, 80 – 92.
Human Adipose Tissue
Choi,J.S., Kim,B.S., Kim,J.Y., Kim,J.D., Choi,Y.C., Yang,H.J., Park,K., Lee,H.Y. and Cho,Y.W. (2011) Decellularized
extracellular matrix derived from human adipose tissue as a potential scaffold for allograft tissue
engineering. Journal of Biomedical Materials Research Part A 97A, 292 – 299.
Chong,L.W., Hsu,Y.C., Chiu,Y.T., Yang,K.C. and Huang,Y.T. (2011) Antifibrotic Effects of Triptolide on Hepatic
Stellate Cells and Dimethylnitrosamineintoxicated Rats. Phytotherapy Research 25, 990 – 999.
Rat Right Ventricle
Choudhary,G., Troncales,F., Martin,D., Harrington,E.O. and Klinger,J.R. (2011) Bosentan Attenuates Right
Ventricular Hypertrophy and Fibrosis in Normobaric Hypoxia Model of Pulmonary Hypertension. The Journal
of Heart and Lung Transplantation, 30, 827 – 833.
Human Colonic Myofibroblasts (HCMFs)
Chrysanthopoulou,A., Mitroulis,I., Kambas,K., Skendros,P., Kourtzelis,I., Vradelis,S., Kolios,G., Aslanidis,S.,
Doumas,M. and Ritis,K. (2011) Tissue factorthrombin signaling enhances the fibrotic activity of
myofibroblasts in systemic sclerosis through upregulation of endothelin receptor A. Arthritis &
Rheumatism, 63, 3586-3597.
Neonatal Mice Cardiac Fibroblasts
Chu,W.F., Li,X.X., Li,C., Wan,L., Shi,H., Song,X.H., Liu,X.Y., Chen,X., Zhang,C. and Shan,H.L. (2011) TGFBR3, a
potential negative regulator of TGF-β signaling, protects cardiac fibroblasts from hypoxiainduced
apoptosis. Journal of cellular physiology, 226, 2586-2594.
Rat Hepatic Stellate Cells (HSC-6)
Chuang,H.Y., Ng,L.T., Lin,L.T., Chang,J.S., Chen,J.Y., Lin,T.C. and Lin,C.C. (2011) Hydrolysable tannins of tropical
almond show antifibrotic effects in TGFβinduced hepatic stellate cells. Journal of the Science of Food and
Agriculture 91, 2777 – 2784.
Ti6Al7Nb Alloy
Cimenoglu,H., Meydanoglu,O., Baydogan,M., Bermek,H., Huner,P. and Kayali,E.S. (2011) Characterization of
thermally oxidized Ti6Al7Nb alloy for biological applications. Metals and Materials International, 17, 765770.
Conte,E., Fruciano,M., Fagone,E., Gili,E., Caraci,F., Iemmolo,M., Crimi,N. and Vancheri,C. (2011) Inhibition of PI3K
Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of
Class I P110 Isoforms. PloS one, 6, e24663.
Rat Lung Tissue
Cui,Y.,Robertson,J., Maharaj,S., Waldhauser,L., Niu,J., Wang,J., Farkas,L., Kolb,M. and Gauldie,J. (2011) Oxidative
stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis. The International
Journal of Biochemistry & Cell Biology, 43, 1122 – 1133.
Rat Lung Tissue
Curley,G.F., Contreras,M., Higgins,B., O'Kane,C., McAuley,D.F., O'Toole,D. and Laffey,J.G. (2011) Evolution of the
Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung
Injury in the Rat. Anesthesiology, 115, 1022 – 1032.
Murine Lung Tissue
Dackor,R.T., Cheng,J., Voltz,J.W., Card,J.W., Ferguson,C.D., Garrett,R.C., Bradbury,J.A., DeGraff,L.M., Lih,F.B.
and Tomer,K.B. (2011) Prostaglandin E2 protects murine lungs from bleomycin-induced pulmonary fibrosis
and lung dysfunction. American Journal of Physiology-Lung Cellular and Molecular Physiology, 301, L645L655.
Murine Small Renal Arteries
Debrah,D.O., Debrah,J.E., Haney,J.L., McGuane,J.T., Sacks,M.S., Conrad,K.P. and Shroff,S.G. (2011) Relaxin
regulates vascular wall remodeling and passive mechanical properties in mice. Journal of Applied
Physiology, 111, 260.
Undetermined Model
de Cogan,F., Booth,A., Gough,J.E. and Webb,S.J. (2011) Conversion of Magnetic Impulses into Cellular Responses by
SelfAssembled NanoparticleVesicle Hydrogels. Angewandte Chemie International Edition 50, 12290 –
12293.
Dees,C., Tomcik,M., Zerr,P., Akhmetshina,A., Horn,A., Palumbo,K., Beyer,C., Zwerina,J., Distler,O. and Schett,G.
(2011) Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Annals of
the Rheumatic Diseases, 70, 1304.
Skin Samples and Cell Culture Supernatants
Dees,C., Akhmetshina,A., Zerr,P., Reich,N., Palumbo,K., Horn,A., Jüngel,A., Beyer,C., Kr÷nke,G. and Zwerina,J.
(2011) Platelet-derived serotonin links vascular disease and tissue fibrosis. The Journal of Experimental
Medicine, 208, 961 – 972.
Dees,C., Tomcik,M., Zerr,P., Akhmetshina,A., Horn,A., Palumbo,K., Beyer,C., Zwerina,J., Distler,O. and Schett,G.
(2011) Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Annals of
the Rheumatic Diseases, doi: 10.1136/ard.2010.134742.
Human Gut Mucosa
Di Sabatino,A., Battista,N., Biancheri,P., Rapino,C., Rovedatti,L., Astarita,G., Vanoli,A., Dainese,E., Guerci,M. and
Piomelli,D. (2011) The endogenous cannabinoid system in the gut of patients with inflammatory bowel
disease. Mucosal Immunology, 4, 574-583.
Murine Lung Tissue
Ditt,V., Lüsebrink,J., Tillmann,R.L., Schildgen,V., Schildgen,O. and Martin,D. (2011) Respiratory Infections by HMPV
and RSV Are Clinically Indistinguishable but Induce Different Host Response in Aged Individuals. PloS one, 6,
719-724.
Self-Assembled Articular Cartilage Constructs
Eleswarapu,S.V., Chen,J.A. and Athanasiou,K.A. (2011) Temporal assessment of ribose treatment on self-assembled
articular cartilage constructs. Biochemical and Biophysical Research Communications 414, 431 – 436.
Murine Lung Tissue
Fritz,D.K., Kerr,C., Fattouh,R., Llop-Guevara,A., Khan,W.I., Jordana,M. and Richards,C.D. (2011) A Mouse Model of
Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway
Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent. The
Journal of Immunology, 186, 1107.
Lung Tissue
Gaggini,F., Laleu,B., Orchard,M., Fioraso-Cartier,L., Cagnon,L., Houngninou-Molango,S., Gradia,A., Duboux,G.,
Merlot,C. and Heitz,F. (2011) Design, Synthesis and Biological Activity of Original Pyrazolo-PyridoDiazepine,-Pyrazine and-Oxazine Dione Derivatives as Novel Dual Nox4/Nox1 inhibitors. Bioorganic &
Medicinal Chemistry 19, 6989 – 6999.
Murine Lung Tissue
Gan,Y., Reilkoff,R., Peng,X., Russell,T., Chen,Q., Mathai,S.K., Homer,R., Gulati,M., Siner,J. and Elias,J. (2011)
Role of semaphorin 7a signaling in TGF 1 induced lung fibrosis and scleroderma related interstitial lung
disease. Arthritis & Rheumatism, 63, 2484 – 2494.
Murine Lung Tissue
Gan,Y., Reilkoff,R., Peng,X., Russell,T., Chen,Q., Mathai,S.K., Homer,R., Gulati,M., Siner,J. and Elias,J. (2011)
Role of semaphorin 7a signaling in TGF 1 induced lung fibrosis and scleroderma related interstitial lung
disease. Arthritis & Rheumatism, 63, 2484 – 2494.
Murine Lung Tissue
Garibaldi,B.T., D'Alessio,F.R., Files,D.C., Mock,J., Chau,E., Sidhaye,V. and King,L. (2011) Regulatory T Cell
Depletion Increases CXCL12-Dependent Fibroproliferation After LPS Injury. American Journal of Respiratory
and Critical Care Medicine, 183, A3982.
Murine Lung Tissue
Gasse,P., Riteau,N., Vacher,R., Michel,M.L., Fautrel,A., di Padova,F., Fick,L., Charron,S., Lagente,V. and Eberl,G.
(2011) IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis.
PloS one, 6, e23185.
Murine Heart Tissue
Georgescu,S.P., Aronovitz,M.J., Iovanna,J.L., Patten,R.D., Kyriakis,J.M. and Goruppi,S. (2011) Decreased
metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking
the transcriptional regulator p8. American Journal of Physiology-Cell Physiology, 301, C1046-C1056.
Human Lung Tissue
Gibbons,M.A., MacKinnon,A.C., Ramachandran,P., Dhaliwal,K., Duffin,R., Phythian-Adams,A.T., van Rooijen,N.,
Haslett,C., Howie,S.E. and Simpson,A.J. (2011) Ly6Chi Monocytes Direct Alternatively Activated Profibrotic
Macrophage Regulation of Lung Fibrosis. American Journal of Respiratory and Critical Care Medicine, 184,
569.
Human Carotic Plaques
Goncalves,I., Stollenwerk,M.M., Lindholm,M.W., Dias,N., Pedro,L.M., Moses,J., Fredrikson,G.N., Nilsson,J. and
Ares,M.P.S. (2011) Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and
cholesteryl ester content. Cardiovascular Pathology, 20, 36-43.
Human Adipose Tissue-Derived Stem Cells
Gomide,V., Zonari,A.A.C., Breyner,N.M., de Goes,A.M. and Pereira,M.M. (2011) Attachment and Proliferation of
Human-Adipose-Tissue-Derived Stem Cells on Bioactive Glass/PVA Hybrid Scaffolds. ISRN Materials Science,
doi: 10.5402/2011/240864.
Murine Lung Homogenate
González-López,A., Astudillo,A., Garcia-Prieto,E., Fernández-García,M.S., López-Vazquez,A., Batalla-Solís,E.,
Taboada,F., Fueyo,A. and Albaiceta,G.M. (2011) Inflammation and Matrix remodelling during repair of
Ventilator-induced lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology,
301, L500-L509.
Murine Colon Tissue
Guan,Q., Ma,Y., Hillman,C.L., Qing,G., Ma,A.G., Weiss,C.R., Zhou,G., Bai,A., Warrington,R.J. and Bernstein,C.N.
(2011) Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and
chronic murine colitis. Molecular Medicine, 17, 646.
Murine Lung Tissue
Hoyles,R.K., Derrett-Smith,E.C., Khan,K., Shiwen,X., Howat,S.L., Wells,A.U., Abraham,D.J. and Denton,C.P. (2011)
An Essential Role for Resident Fibroblasts in Experimental Lung Fibrosis Is Defined by Lineage-Specific
Deletion of High-Affinity Type II Transforming Growth Factor {beta} Receptor. American Journal of
Respiratory and Critical Care Medicine, 183, 249.
Murine Myofibroblasts
Huang,X., Gai,Y., Yang,N., Lu,B., Samuel,C.S., Thannickal,V.J. and Zhou,Y. (2011) Relaxin Regulates Myofibroblast
Contractility and Protects against Lung Fibrosis. The American Journal of Pathology,
http://dx.doi.org/10.1016/j.ajpath.2011.08.018.
Murine Diaphragm
Huang,P., Cheng,G., Lu,H., Aronica,M., Ransohoff,R.M. and Zhou,L. (2011) Impaired respiratory function in mdx and
mdx/utrn+/- mice. Muscle & Nerve, 43, 263-267.
Human Fibroblasts
Imaizumi,K., Hashimoto,N., Hashimoto,I., Imai,N., Tomita,Y., Kounou,T., Sakamoto,K., Aoyama,D., Ogawa,M.T.
and Kusunose,S.I. (2011) The Role Of Interleukin-17/th17 In Human Interstitial Pneumonia. Am J Respir Crit
Care Med, 183, A4282.
Murine Lung Tissue
Imazu,Y., Yanagi,S., Miyoshi,K., Tsubouchi,H., Yamashita,S., Matsumoto,N., Ashitani,J., Kangawa,K. and
Nakazato,M. (2011) Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar
epithelial cells and suppressing lung inflammation. European Journal of Pharmacology 672, 153 – 158.
Fibroblasts
Iyer,P., Walker,K.J. and Madihally,S.V. (2011) Increased matrix synthesis by fibroblasts with decreased proliferation
on synthetic chitosangelatin porous structures. Biotechnology and Bioengineering doi: 10.1002/bit.24396.
Decellularised Porcine-Heart Valves and Autologous Endothelial Progenitor Cell Derived Endothelial
Cells
Jordan,J.E., Williams,J.K., Lee,S.J., Raghavan,D., Atala,A. and Yoo,J.J. (2011) Bioengineered self-seeding heart
valves. The Journal of Thoracic and Cardiovascular Surgery 143, 201 – 208.
Human Periodontal Ligament Stem cells (hPDLSCs)
Jung,I.H., Park,J.C., Kim,J.C., Jeon,D.W., Choi,S.H., Cho,K.S., Im,G.I., Kim,B.S. and Kim,C.S. (2011) Novel
Application of Human Periodontal Ligament Stem Cells and Water-Soluble Chitin for Collagen Tissue
Regeneration: In Vitro and In Vivo Investigations. Tissue Engineering Part A, doi:
10.1089/ten.tea.2011.0164.
Murine Lung Tissue
Kamata,H., Tasaka,S., Inoue,K., Miyamoto,K., Nakano,Y., Shinoda,H., Kimizuka,Y., Fujiwara,H., Ishii,M. and
Hasegawa,N. (2011) Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic
changes in mice. Experimental Biology and Medicine, 236, 315.
Myofibroblasts
Kambas,K., Chrysanthopoulou,A., Kourtzelis,I., Skordala,M., Mitroulis,I., Rafail,S., Vradelis,S., Sigalas,I., Wu,Y.Q.
and Speletas,M. (2011) Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia
Model by Activating the Extrinsic Coagulation Cascade. The Journal of Immunology, 186, 6568.
Murine Dorsal Tissue
Kavalukas,S.L., Uzgare,A.R., Bivalacqua,T.J. and Barbul,A. (2011) Arginase inhibition promotes wound healing in
mice. Surgery, http://dx.doi.org/10.1016/j.surg.2011.07.012.
Kavian,N., Servettaz,A., Marut,W., Nicco,C., Chéreau,C., Weill,B. and Batteux,F. (2011) Sunitinib inhibits the
phosphorylation of PDGFreceptor beta in the skin of mice with sclerodermalike features and prevents the
development of the disease. Arthritis & Rheumatism, doi: 10.1002/art.34354.
Murine Tissue and Cultured Mesangial Cells
Kang,Y.S., Lee,M.H., Song,H.K., Hyun,Y.Y., Cha,J.J., Ko,G.J., Kim,S.H., Lee,J.E., Han,J.Y. and Cha,D.R. (2011)
Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice.
Nephrology Dialysis Transplantation, 26, 1194 – 1204.
Human Myocardial Tissue
Kasner,M., Westermann,D., Lopez,B., Gaub,R., Escher,F., Kuhl,U., Schultheiss,H.P. and Tschope,C. (2011) Diastolic
Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure
and Normal Ejection Fraction. Journal of the American College of Cardiology, 57, 977-985.
Rat and Murine Lung Tissue
Kass,D., Loh,K., Borczuk,A., Tedrow,J., Juan Guardela,B., Kaminski,N. and Greenberg,S. (2011) Cytokine-Like
Factor I (CLF1) Expression Is Increased In Idiopathic Pulmonary Fibrosis (IPF) And Promotes Inflammation But
Decreases Fibrosis In Bleomycin Injury. American Journal of Respiratory and Critical Care Medicine, 183,
A2710.
Murine Lung Tissue
Kearley,J., Erjefalt,J.S., Andersson,C., Benjamin,E., Jones,C.P., Robichaud,A., Pegorier,S., Brewah,Y.,
Burwell,T.J. and Bjermer,L. (2011) IL-9 governs allergen-induced mast cell numbers in the lung and chronic
remodeling of the airways. American Journal of Respiratory and Critical Care Medicine, 183, 865.
Lung Tissue
Kelly,M.M., Hasan,S.A., Gwozd,C., Kooi,C. and Oyelusi,W. (2011) Corticosteroid Treatment Significantly Reduces
Neutrophilic Airway Inflammation And Remodeling In A Model Of Severe Asthma. American Journal of
Respiratory and Critical Care Medicine, 183, A2544.
Murine Lung Tissue
Khalifah,A.P., Young,S.K., Campbell,M., Briones,N., Yamashita,C. and Downey,G.P. (2011) Protein Tyrosine
Phosphatase-± Deficiency In Mice Protects Against Bleomycin-Induced Lung Fibrosis And Causes Aberrant
Response To TGF {superscript 2}. American Journal of Respiratory and Critical Care Medicine, 183, A6431.
Human Marrow Derived Stromal Cells
Khan,M.R., Donos,N., Salih,V. and Brett,P.M. (2011) The enhanced modulation of key bone matrix components by
modified Titanium implant surfaces. Bone, doi: 10.1016/j.bone.2011.07.040.
Chondrocytes
Khanarian,N.T., Jiang,J., Wan,L.Q., Mow,V.C. and Lu,H.H. (2011) A Hydrogel-Mineral Composite Scaffold for
Osteochondral Interface Tissue Engineering. Tissue Engineering, Part A, doi: 10.1089/ten.TEA.2011.0279.
Murine Lung Tissue
Kim,D.Y., Kwon,E.Y., Hong,G.U., Lee,Y.S., Lee,S.H. and Ro,J.Y. (2011) Cigarette smoke exacerbates mouse allergic
asthma through Smad proteins expressed in mast cells. Respiratory Research, 12, 49.
Murine Skin Tissue
Kim,S.E., Lee,J.O., Kwon,H.B., Ahn,B.J. and Lee,A-Y. (2011) Greater Collagen Deposition with the Microneedle
Therapy System Than with Intense Pulsed Light. Dermatologic Surgery 37, 336 – 341.
Murine Lung Tissue
Kim,T.H., Kim,S.H., Seo,J.Y., Chung,H., Kwak,H.J., Lee,S.K., Yoon,H.J., Shin,D.H., Park,S.S. and Sohn,J.W. (2011)
Blockade of the Wnt/ β-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis. The Tohoku
Journal of Experimental Medicine, 223, 45-54.
Murine and Human Lung Fibroblasts
Kitamura,H., Cambier,S., Somanath,S., Barker,T., Minagawa,S., Markovics,J., Goodsell,A., Publicover,J.,
Reichardt,L. and Jablons,D. (2011) Mouse and human lung fibroblasts regulate dendritic cell trafficking,
airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest. 121,
2863 – 2875.
Murine Lung Tissue
Kneidinger,N., Yildirim,A.O., Callegari,J., Takenaka,S., Stein,M.M., Dumitrascu,R., Bohla,A., Bracke,K.R.,
Morty,R.E. and Brusselle,G.G. (2011) Activation of the WNT/β-Catenin Pathway Attenuates Experimental
Emphysema. American Journal of Respiratory and Critical Care Medicine, 183, 723.
Human Auricular Perichondrium
Kobayashi,S., Takebe,T., Inui,M., Iwai,S., Kan,H., Zheng,Y.W., Maegawa,J. and Taniguchi,H. (2011) Reconstruction
of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium. Proceedings of the
National Academy of Sciences, 108, 14479-14484.
Porcine Annulus Fibrosus Cells
Koepsell,L., Remund,T., Bao,J., Neufeld,D., Fong,H. and Deng,Y. Tissue engineering of annulus fibrosus using
electrospun fibrous scaffolds with aligned polycaprolactone fibers. Journal of Biomedical Materials
Research Part A, doi: 10.1002/jbm.a.33216.
Primary Porcine Annulus Fibrosus Cells
Koepsell,L., Zhang,L., Neufeld,D., Fong,H. and Deng,Y. (2011) Electrospun nanofibrous polycaprolactone scaffolds
for tissue engineering of annulus fibrosus. Macromolecular bioscience, 11, 391 – 399.
Murine Lung Tissue
Kramer,E.L., Hardie,W.D., Mushaben,E.M., Acciani,T.H., Pastura,P.A., Korfhagen,T.R., Hershey,G.K., Whitsett,J.A.
and Le Cras,T.D. (2011) Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model
of Noninflammatory Lung Disease. Journal of Applied Physiology, doi: 10.1152/japplphysiol.00737.2011.
Lung Fibroblasts
Lam,A.P., Sennello,J.A., Flozak,A.S., Russell,S.R. and Gottardi,C.J. (2011) Loss Of Wnt/beta-Catenin Signaling
Alters Lung Fibroblast Response To Fibrotic Injury. American Journal of Respiratory and Critical Care
Medicine, 183, A2702.
Rat Kidney Tissue
Lan,H., Yanfei,Q., Xianglu,R., Jianmin,J., Qinglin,Y., Johji,Y., Michael,M. and Yuhao,L. (2011) The Ayurvedic
Medicine Salacia oblonga Attenuates Diabetic Renal Fibrosis in Rats: Suppression of Angiotensin II/AT1
Signaling. Evidence-Based Complementary and Alternative Medicine, doi: 10.1093/ecam.nep095.
Human Adult Hepatocytes
Lang,R., Stern,M.M., Smith,L., Liu,Y., Bharadwaj,S., Liu,G., Baptista,P.M., Bergman,C.R., Soker,S. and Yoo,J.J.
(2011) Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix.
Biomaterials, 32, 7042 – 7052.
Fibroblasts
Lecca,M.R., Maag,C., Berger,E.G. and Hennet,T. (2011) Fibrotic response in fibroblasts from congenital disorders of
glycosylation. Journal of Cellular and Molecular Medicine, 15, 1788-1796.
Lee,H.M., Park,I.H., Choi,H. and Kim,Y.D. (2011) Effect Of Caffeic Acid On Myofibroblast Differentiation And
Collagen Production In Nasal Polyp-Derived Fibroblast. American Journal of Respiratory and Critical Care
Rat Lung Tissue
Lee,S.H., Jang,A.S., Kwon,J.H., Park,S.K., Won,J.H. and Park,C.S. (2011) Mesenchymal Stem Cell Transfer
Suppresses Airway Remodeling in a Toluene Diisocyanate-Induced Murine Asthma Model. Allergy, Asthma &
Immunology Research, 3, 205.
Lee,T.H., Lee,S.M., Lee,D.Y., Son,Y., Chung,D.K., Baek,N.I. and Kim,J. (2011) A glycosidic spinasterol from Koreana
stewartia promotes procollagen production and inhibits matrix metalloproteinase-1 expression in UVBirradiated human dermal fibroblasts. Biological & Pharmaceutical Bulletin, 34, 768-773.
Ligament-Bone (LTB) Relevant Cells
Lee,J., Choi,W.I., Tae,G., Kim,Y.H., Kang,S.S., Kim,S.E., Kim,S.H., Jung,Y. and Kim,S.H. (2011) Enhanced
regeneration of the ligament–bone interface using a poly(l-lactide–co-ε-caprolactone) scaffold
with local delivery of cells/BMP-2 using a heparin-based hydrogel. Acta Biomaterialia, 7, 244 – 257.
Human Osteoblastic MG63 Cells
Li,J., Wei,L., Sun,J. and Guan,G. (2011) Effect of ionic products of dicalcium silicate coating on osteoblast
differentiation and collagen production via TGF-β pathway. Journal of Biomaterials Applications doi:
10.1177/08853282114/6393.
Murine Lung Tissue
Li,M., Krishnaveni,M.S., Li,C., Zhou,B., Xing,Y., Banfalvi,A., Li,A., Lombardi,V., Akbari,O. and Borok,Z. (2011)
Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary
fibrosis. J Clin Invest., 121, 277 – 287.
Human Fibroblasts
Lindahl,K., Barnes,A.M., FratzlZelman,N., Whyte,M.P., Hefferan,T.E., Makareeva,E., Brusel,M., Yaszemski,M.J.,
Rubin,C.J. and Kindmark,A. (2011) COL1 Cpropeptide cleavage site mutations cause high bone mass
osteogenesis imperfecta. Human Mutation 32, 598 – 609.
Lo,Y.T., Tsai,Y.H., Wu,S.J., Chen,J.R. and Chao,J.C.J. (2011) Ginsenoside Rb1 Inhibits Cell Activation and Liver
Fibrosis in Rat Hepatic Stellate Cells. Journal of Medicinal Food 14, 1135 – 1143.
Murine Fibroblasts
Lu,H., Hoshiba,T., Kawazoe,N. and Chen,G. (2011) Autologous extracellular matrix scaffolds for tissue engineering.
Biomaterials, 32, 2489 – 2499.
Primary Mouse Lung Fibroblasts
Luchsinger,L.L., Patenaude,C.A., Smith,B.D. and Layne,M.D. (2011) Myocardin Related Transcription Factor-A
Complexes Activate Type I Collagen Expression in Lung Fibroblasts. Journal of Biological Chemistry, doi
10.1074/jbc.M111.276931.
Murine Lung
Luckhardt,T.R., Coomes,S.M., Trujillo,G., Stoolman,J.S., Vannella,K.M., Bhan,U., Wilke,C.A., Moore,T.A.,
Toews,G.B. and Hogaboam,C. (2011) TLR9-induced interferon is associated with protection from
gammaherpesvirus-induced exacerbation of lung fibrosis. Fibrogenesis & Tissue Repair, 4, 18.
Murine Lung Tissue
Luzina,I.G., Lockatell,V., Todd,N.W., Keegan,A.D., Hasday,J.D. and Atamas,S.P. (2011) Splice isoforms of human
interleukin 4 are functionally active in mice in vivo. Immunology 132, 385 – 393.
Murine Lung Tissue
Luzina,I.G., Lockatell,V., Todd,N.W., Highsmith,K., Keegan,A.D., Hasday,J.D. and Atamas,S.P. (2011) Alternatively
spliced variants of interleukin-4 promote inflammation differentially. Journal of leukocyte biology, 89,
763.
Lung Tissue
Madala,S., Davidson,C., Schmidt,S., LeCras,T., Korfhagen,T., Ikegami,M. and Hardie,W. (2011) Pharmacologic
Inhibition Of MEK Reverses Transforming Growth Factor-Alpha Induced Pulmonary Fibrosis. American
Journal of Respiratory and Critical Care Medicine, 183, A5979.
Rat Lung Tissue
Mahmood,J., Jelveh,S., Calveley,V., Zaidi,A., Doctrow,S.R. and Hill,R.P. (2011) Mitigation of Lung Injury after
Accidental Exposure to Radiation. Radiation Research 176, 770 – 780.
Murine Lung Tissue
Manali,E., Moschos,C., Triantafillidou,C., Kotanidou,A., Psallidas,I., Karabela,S., Roussos,C., Papiris,S.,
Armaganidis,A. and Stathopoulos,G. (2011) Static and dynamic mechanics of the murine lung after
intratracheal bleomycin. BMC Pulmonary Medicine, 11, 33.
Osteoblastic MC3T3-E1 Cell Cultures
Manzano,M., Lozano,D., Arcos,D., Portal-N· ez,S., Orden,C.L., Esbrit,P. and Vallet-RegíM. (2011) Comparison of the
osteoblastic activity conferred on Si-doped hydroxyapatite scaffolds by different osteostatin coatings. Acta
Biomaterialia, 7, 3555 – 3562.
Human Mesenchymal Stromal/Stem Cells
Mariner,P.D., Johannesen,E. and Anseth,K.S. (2011) Manipulation of miRNA activity accelerates osteogenic
differentiation of hMSCs in engineered 3D scaffolds. Journal of Tissue Engineering and Regenerative
Medicine doi: 10.1002/term.435.
Rat Joint Regions and Non-Joint Regions of Median and Sciatic Nerves
Mason,S. and Phillips,J.B. (2011) An ultrastructural and biochemical analysis of collagen in rat peripheral nerves:
the relationship between fibril diameter and mechanical properties. Journal of the Peripheral Nervous
System, 16, 261-269.
Murine Model of Chronic Eosinophilic Ileitis
Masterson,J.C., McNamee,E.N., Jedlicka,P., Fillon,S., Ruybal,J., Hosford,L., Rivera-Nieves,J., Lee,J.J. and
Furuta,G.T. (2011) CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. The American
Journal of Pathology 179, 2302 – 2314.
Lung Tissue
McCart,E., Day,R.M. and Mungunsukh,O. (2011) Effect Of Exogenous Hgf And Nk2 Expression In A Bleomycin Model
Of Pulmonary Fibrosis. Am J Respir Crit Care Med, 183, A5994.
Murine Distal Ileum
McLarren,K.W., Cole,A.E., Weisser,S.B., Voglmaier,N.S., Conlin,V.S., Jacobson,K., Popescu,O., Boucher,J.L. and
Sly,L.M. (2011) SHIP-Deficient Mice Develop Spontaneous Intestinal Inflammation and Arginase-Dependent
Fibrosis. The American Journal of Pathology, 179, 180 – 188.
Rodent Lung Tissue
McDonald,J., Doyle-Eisele,M., Sheller,M., Crowther,R. and Liu,Y. (2011) AZX100, An HSP20 Mimic, Decreases
Fibrosis And Alters The Circadian Rhythm And Cytoskeleton Remodeling Molecular Pathways In The
Bleomycin Induced Fibrosis Model. American Journal of Respiratory and Critical Care Medicine, 183, A6444.
Murine Distal Ileum
McLarren,K.W., Cole,A.E., Weisser,S.B., Voglmaier,N.S., Conlin,V.S., Jacobson,K., Popescu,O., Boucher,J.L. and
Sly,L.M. (2011) SHIP-Deficient Mice Develop Spontaneous Intestinal Inflammation and Arginase-Dependent
Fibrosis. The American Journal of Pathology, doi: 10.1016/j.ajpath.2011.03.018.
Mi,S., Li,Z., Yang,H.Z., Liu,H., Wang,J.P., Ma,Y.G., Wang,X.X., Liu,H.Z., Sun,W. and Hu,Z.W. (2011) Blocking IL17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1β-Dependent and Independent Mechanisms. The Journal of Immunology, 187, 3003-3014.
Murine Lung
Mitaka,K., Miyazaki,Y., Yasui,M., Furuie,M., Miyake,S., Inase,N. and Yoshizawa,Y. (2011) Th2-Biased Immune
Responses Are Important in a Murine Model of Chronic Hypersensitivity Pneumonitis. International archives
of allergy and immunology, 154, 264-274.
Lung Tissue
Mungunsukh,O., McCart,E. and Day,R.M. (2011) Effect Of Exogenous HGF And NK2 Expression In A Bleomycin Model
Of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 183, A5994.
Murine Lower Muscle
Nevo,Y., Aga-Mizrachi,S., Elmakayes,E., Yanay,N., Ettinger,K., Elbaz,M., Brunschwig,Z., Dadush,O., Elad-Sfadia,G.
and Haklai,R. (2011) The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves
Muscle Strength in dy2J/dy2J Mouse Model of Muscular Dystrophy. PLoS One 6(3): e18049.
Murine Lung Tissue
Nicola,T., Ambalavanan,N., Zhang,W., James,M.L., Rehan,V.K., Halloran,B.A., Olave,N., Bulger,A., Oparil,S. and
Chen,Y.F. (2011) Hypoxia-Induced Inhibition of Lung Development is Attenuated by the Peroxisome
Proliferator-Activated Receptor- γAgonist Rosiglitazone. American Journal of Physiology-Lung Cellular and
Molecular Physiology, 301, L125.
Murine Lung
Ogawa,H., Azuma,M., Muto,S., Nishioka,Y., Honjo,A., Tezuka,T., Uehara,H., Izumi,K., Itai,A. and Sone,S. (2011)
Iκβ-kinase β inhibitor IMD0354 suppresses airway remodelling in a Dermatophagoides
pteronyssinussensitized mouse model of chronic asthma. Clinical & Experimental Allergy, 41, 104-115.
Human Fibroblasts
Oh,E.J., Kim,T.K., Shin,J.H., Choi,J.H. and Chung,H.Y. (2011) Biologic Filler Using Human Fibroblasts and Placenta
Extracts. Journal of Craniofacial Surgery, 22, 1557.
Murine Lung Tissue
Oh,K., Park,H.B., Byoun,O.J., Shin,D.M., Jeong,E.M., Kim,Y.W., Kim,Y.S., Melino,G., Kim,I.G. and Lee,D.S. (2011)
Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary
inflammation and fibrosis in bleomycin-treated mice. The Journal of Experimental Medicine 208,1707.
Human Fibroblasts
Ogawa,T., Imaizumi,K., Hashimoto,N., Hashimoto,I., Imai,N., Tomita,Y., Kounou,T., Sakamoto,K., Aoyama,D. and
Kusunose,M. (2011) The Role Of Interleukin-17/Th17 In Human Interstitial Pneumonia. American Journal of
Human Skin Samples
Oh,M.H., Oh,S.Y., Yu,J., Myers,A.C., Leonard,W.J., Liu,Y.J., Zhu,Z. and Zheng,T. (2011) IL-13 Induces Skin Fibrosis
in Atopic Dermatitis by Thymic Stromal Lymphopoietin. The Journal of Immunology, 186, 7232.
Murine Skin Tissue
Olaso,E., Lin,H.C., Wang,L.H. and Friedman,S.L. (2011) Impaired dermal wound healing in discoidin domain
receptor 2-deficient mice associated with defective extracellular matrix remodeling. Fibrogenesis & Tissue
Repair, 4, 5.
Hamster Peritoneal Macrophages
Osorio,Y., Travi,B.L., Renslo,A.R., Peniche,A.G., Melby,P.C. and Geary,T.G. (2011) Identification of Small Molecule
Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System. PLoS
Neglected Tropical Diseases, 5, 111-126.
Murine Colonic Tissue
Oz,H.S., Zhong,J. and de Villiers,W.J.S. (2011) Osteopontin Ablation Attenuates Progression of Colitis in TNBS
Model. Digestive Diseases and Sciences, doi: 10.1007/s10620-011-2009-z.
Oz,H.S., Zhong,J. and de Villiers,W.J.S. (2011) Osteopontin Ablation Attenuates Progression of Colitis in TNBS
Model. Digestive Diseases and Sciences, doi: 10.1007/s10620-011-2009-z.
Collagen Type I Isolated from Rabbit, Lamb and Human Skin
Pacak,C.A., Powers,J.M. and Cowan,D.B. (2011) Ultrarapid Purification of Collagen Type I for Tissue Engineering
Applications. Tissue Engineering Part C: Methods, 17, 879 – 885.
Rat Hepatic Stellate Cells HSC-T6
Pan,T.L., Wang,P.W., Leu,Y.L., Wu,T.H. and Wu,T.S. (2011) Inhibitory effects of Scutellaria baicalensis extract on
hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via
Bax and caspase pathway. Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2011.12.028.
Park,I.H., Choi,H., Lee,H.M. and Kim,Y.D. (2011) Effect of Berberine on Nasal Polyp-derived Fibroblast.
Otolaryngology--Head and Neck Surgery, 145, 119.
Rat Lung Tissue
Pauluhn,J. and Wiemann,M. (2011) Siderite (FeCO 3) and magnetite (Fe3O4) overload-dependent pulmonary toxicity
is determined by the poorly soluble particle not the iron content. Inhalation Toxicology, 23, 763-783.
Murine Fibrosarcoma L929 Fibroblasts and Primary Lung Fibroblasts
Pfau,J.C., Li,S., Holland,S. and Sentissi,J.J. (2011) Alteration of fibroblast phenotype by asbestos-induced
autoantibodies. Journal of Immunotoxicology, 8, 159 – 169.
Murine Bronchoalveolar Lavage Fluid
Pedroza,M., Schneider,D.J., Karmouty-Quintana,H., Coote,J., Shaw,S., Corrigan,R., Molina,J.G., Alcorn,J.L.,
Galas,D. and Gelinas,R. (2011) Interleukin-6 Contributes to Inflammation and Remodeling in a Model of
Adenosine Mediated Lung Injury. PloS one, 6, e22667.
Murine Lung Tissue
Peng,X., Mathai,S.K., Murray,L.A., Russell,T., Reilkoff,R., Chen,Q., Gulati,M., Elias,J.A., Bucala,R. and Gan,Y.
(2011) Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth
factor β1-induced lung fibrosis. Fibrogenesis & Tissue Repair, 4, 12.
L929 Fibroblasts and Primary Lung Fibroblasts
Pfau,J.C., Li,S., Holland,S. and Sentissi,J.J. (2011) Alteration of fibroblast phenotype by asbestos-induced
autoantibodies. Journal of Immunotoxicology, 8, 159 - 169.
Primary Human Tenocytes
Poulsen,R.C., Carr,A.J. and Hulley,P.A. (2011) Protection against Glucocorticoid-Induced Damage in Human
Tenocytes by Modulation of ERK, Akt, and Forkhead Signaling. Endocrinology, 152, 503.
Accellularised Human Flexor Tendons
Pridgen,B.C., Woon,C.Y.L., Kim,M., Thorfinn,J., Lindsey,D., Pham,H. and Chang,J. (2011) Flexor Tendon Tissue
Engineering: Acellularization of Human Flexor Tendons with Preservation of Biomechanical Properties and
Biocompatibility. Tissue Engineering Part C: Methods, 17, 819 – 828.
Murine Lung Tissue
Przybyszewska,M., Miłoszewska,J., Rzońca,S., Trembacz,H., Pyśniak,K., Kotlarz,A., Swoboda,P., Zalewska,M. and
Małecki,M. (2011) Soluble TNF-α Receptor I Encoded on Plasmid Vector and Its Application in Experimental
Gene Therapy of Radiation-Induced Lung Fibrosis. Archivum immunologiae et therapiae experimentalis,
59, 315 - 326.
Murine Lung Tissue
Rabolli,V., Re,S.L., Uwambayinema,F., Yakoub,Y., Lison,D. and Huaux,F. (2011) Lung fibrosis induced by crystalline
silica particles is uncoupled from lung inflammation in NMRI mice. Toxicology Letters, 203, 127 – 134.
Dog Articular Chondrocytes
Rai,M.F., Graeve,T., Twardziok,S. and Schmidt,M.F.G. (2011) Evidence for Regulated Interleukin-4 Expression in
Chondrocyte-Scaffolds under In Vitro Inflammatory Conditions. PloS one, 6, e25749.
Murine Lung
Ravichandran,P., Baluchamy,S., Gopikrishnan,R., Biradar,S., Ramesh,V., Goornavar,V., Thomas,R., Wilson,B.L.,
Jeffers,R. and Hall,J.C. (2011) Pulmonary Biocompatibility Assessment of Inhaled Single-wall and Multiwall
Carbon Nanotubes in BALB/c Mice. Journal of Biological Chemistry, 286, 29725-29733.
Murine Colon
Reardon,C., Lechmann,M., Brüstle,A., Gareau,M.G., Shuman,N., Philpott,D., Ziegler,S.F. and Mak,T.W. (2011)
Thymic Stromal Lymphopoetin-Induced Expression of the Endogenous Inhibitory Enzyme SLPI Mediates
Recovery from Colonic Inflammation. Immunity, 35, 223 – 235.
Human Mesenchymal Cells
Re’em,T., Kaminer-Israeli,Y., Ruvinov,E. and Cohen,S. (2011) Chondrogenesis of hMSC in affinity-bound TGF-beta
scaffolds. Biomaterials 33, 751 – 761.
Murine Lung Tissue
Reilkoff,R., Russell,T., Peng,X., Gulati,M., Homer,R., Elias,J.A. and Herzog,E. (2011) Semaphorin 7A Expression On
Lymphocytes Promotes Alternative Macrophage Activation In Murine Models Of Lung Fibrosis And Human IPF.
Murine Lung Tissue
Reinke,C., Bevans-Fonti,S., Grigoryev,D.N., Drager,L.F., Myers,A.C., Wise,R.A., Schwartz,A.R., Mitzner,W. and
Polotsky,V.Y. (2011) Chronic intermittent hypoxia induces lung growth in adult mice. American Journal of
Physiology-Lung Cellular and Molecular Physiology, 300, L266.
Rat Aorta
Roan,J.N., Tsai,Y.C., Chen,I.W., Chang,S.W., Huang,C.C. and Lam,C.F. (2011) Inhibition of cyclooxygenase-2
modulates phenotypic switching of vascular smooth muscle cells during increased aortic blood flow. Heart
and Vessels, doi: 10.1007/s00380-011-0148-y.
Murine Lung Tissue
Russo,R.C., Garcia,C.C., Barcelos,L.S., Rachid,M.A., Guabiraba,R., RoffE., Souza,A.L.S., Sousa,L.P., Mirolo,M.
and Doni,A. (2011) Phosphoinositide 3-kinase plays a critical role in bleomycin-induced pulmonary
inflammation and fibrosis in mice. Journal of Leukocyte Biology, 89, 269.
Saito,S., Takayama,Y., Mizumachi,K. and Suzuki,C. (2011) Lactoferrin promotes hyaluronan synthesis in human
dermal fibroblasts. Biotechnology letters, 33, 33 – 39.
Coprothermobacter proteolyticus and Methanothermobacter thermautotrophicus
Sasaki,K., Morita,M., Sasaki,D., Nagaoka,J., Matsumoto,N., Ohmura,N. and Shinozaki,H. (2011) Syntrophic
degradation of proteinaceous materials by the thermophilic strains Coprothermobacter proteolyticus and
Methanothermobacter thermautotrophicus. Journal of Bioscience and Bioengineering 112, 469 – 472.
Murine Lung Tissue
Satish,K. (2011) Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice. Pulmonary Medicine,
doi: 10.1155/2011/653524.
Co-Culture of Fibrocytes with Airway Smooth Muscle
Saunders,R., Kaur,D., Doe,C., Siddiqui,S., Wardlaw,A., Bradding,P. and Brightling,C.E. (2011) Co-Culture Of
Fibrocytes With Airway Smooth Muscle Effects Fibrocyte Phenotype And Composition Of The Extracellular
Milieu. American Journal of Respiratory and Critical Care Medicine, 183, A4055.
Rat HSC-T6 Hepatic Stellate Cells
Shin,E., Lee,C., Sung,S.H., Kim,Y.C., Hwang,B.Y. and Lee,M.K. (2011) Antifibrotic activity of coumarins from
Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. Journal of Natural Medicines, 65, 370 - 374.
Different Cell Lines
Shona Pek,Y. and Wan,A.C.A. (2011) Characterization of early extracellular matrix secretions in a three-dimensional
thixotropic cell culture system. Acta Biomaterialia 7, 3981 – 3987.
Human Periodontal Ligament Stem Cells
Song,D., Park,J., Jung,I., Choi,S., Cho,K. and Kim,C. (2011) Enhanced adipogenic differentiation and reduced
collagen synthesis induced by human periodontal ligament stem cells might underlie the negative effect of
recombinant human bone morphogenetic protein2 on periodontal regeneration. Journal of periodontal
research 46, 193 – 203.
Murine Lung Tissue
Sugino,K., Ito,T., Muramatsu,Y., Tatebe,J., Morita,T., Matsuda,K., Azuma,A. and Homma,S. (2011) NAcetylcysteine And Pirfenidone Attenuate Expression Of Epithelial Mesenchymal Transition In Murine
Bleomycin-Induced Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 183,
A4288.
Murine Kidney
Sugiyama,N., Kohno,M. and Yokoyama,T. (2011) Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an
NPHP2 mouse model. Nephrology Dialysis Transplantation doi: 10.1093/ndt/gfr550.
Rodent Models of Lung and Kidney Fibrosis and Wound Healing
Swaney,J.S., Chapman,C., Correa,L.D., Stebbins,K.J., Broadhead,A.R., Bain,G., Santini,A.M., Darlington,J.,
King,C.D. and Baccei,C.S. (2011) Pharmacokinetic and Pharmacodynamic Characterization of an Oral
Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist. Journal of Pharmacology and Experimental
Therapeutics, 336, 693.
Human MG63 Osteosarcoma Cells
Tan,F., Naciri,M. and AlRubeai,M. (2011) Osteoconductivity and growth factor production by MG63 osteoblastic
cells on bioglasscoated orthopedic implants. Biotechnology and Bioengineering 108, 454 – 464.
Murine Lung Tissue
Teeguarden,J.G., Webb-Robertson,B.J., Waters,K.M., Murray,A.R., Kisin,E.R., Varnum,S.M., Jacobs,J.M.,
Pounds,J.G., Zanger,R.C. and Shvedova,A.A. (2011) Comparative Proteomics and Pulmonary Toxicity of
Instilled Single-Walled Carbon Nanotubes, Crocidolite Asbestos, and Ultrafine Carbon Black in Mice.
Toxicological Sciences, 120, 123 – 135.
Teh,T.K.H., Toh,S.L. and Goh,J.C.H. (2011) Aligned Hybrid Silk Scaffold for Enhanced Differentiation of
Mesenchymal Stem Cells into Ligament Fibroblasts. Tissue Engineering Part C: Methods, 17, 687 – 703.
Tirkkonen,L., Halonen,H., Hyttinen,J., Kuokkanen,H., Sievänen,H., Koivisto,A.M., Mannerström,B., Sándor,G.K.B.,
Suuronen,R. and Miettinen,S. (2011) The effects of vibration loading on adipose stem cell number, viability
and differentiation towards bone-forming cells. Journal of The Royal Society Interface, 8, 1736-1747.
Porcine Chondrocytes
Tran,S.C., Cooley,A.J. and Elder,S.H. (2011) Effect of a mechanical stimulation bioreactor on tissue engineered,
scaffoldfree cartilage. Biotechnology and Bioengineering 108, 1421 – 1429.
Osteoblast Cell Cultures
Tulyaganov,D., Agathopoulos,S., Valerio,P., Balamurugan,A., Saranti,A., Karakassides,M. and Ferreira,J. (2011)
Synthesis, bioactivity and preliminary biocompatibility studies of glasses in the system CaO-MgO-SiO2-Na2OP2O5-CaF2. Journal of Materials Science: Materials in Medicine, 22, 217-227.
Turner,J.D., Jenkins,G.R., Hogg,K.G., Aynsley,S.A., Paveley,R.A., Cook,P.C., Coles,M.C. and Mountford,A.P. (2011)
CD4+ CD25+ Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused
by Schistosome Infection. PLoS Neglected Tropical Diseases, 5, e1269.
Primary Mesangial Cells, Parietal Epithelial Cells and Macrophages
Urushihara,M., Ohashi,N., Miyata,K., Satou,R., Acres,O.W. and Kobori,H. (2011) Addition of Angiotensin II Type 1
Receptor Blocker to CCR2 Antagonist Markedly Attenuates Crescentic Glomerulonephritis. Hypertension,
57, 586-593.
Porcine Anterior Cruciate Ligament Fibroblasts
Vavken,P., Joshi,S.M. and Murray,M.M. (2011) Fibrin concentration affects ACL fibroblast proliferation and collagen
synthesis. The Knee, 18, 42-46.
Primary Human Tenocytes
Vetrano,M., d’Alessandro,F., Torrisi,M.R., Ferretti,A., Vulpiani,M.C. and Visco,V. (2011) Extracorporeal shock wave
therapy promotes cell proliferation and collagen synthesis of primary cultured human tenocytes. Knee
Surgery, Sports Traumatology, Arthroscopy, 19, 2159 – 2168.
Murine Lung Tissue
Wang,X., Katwa,P., Podila,R., Chen,P., Ke,P.C., Rao,A.M., Walters,D.M., Wingard,C.J. and Brown,J.M. (2011) Multiwalled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice. Particle and fibre
toxicology, 8, 24.
Murine Lung Tissue
Wang,X., Xia,T., Ntim,S.A., Ji,Z., Lin,S., Meng,H., Chung,C.H., George,S., Zhang,H. and Wang,M. (2011) The
Dispersal State of Multi-walled Carbon Nanotubes Elicits Pro-Fibrogenic Cellular Responses that Correlate
with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung. ACS Nano 5, 9772 – 9787.
Horse Mid-Metacarpal Superficial Digital Flexor Tendon
Watts,A.E., Nixon,A.J., Yeager,A.E. and Mohammed,H.O. (2011) A collagenase gel/physical defect model for
controlled induction of superficial digital flexor tendonitis. Equine Veterinary Journal, doi: 10.1111/j.20423306-2011.00471.x.
Male, Fetal Derived Embryonic-Like Stem Cells
Watts,A.E., Yeager,A.E., Kopyov,O.V. and Nixon,A.J. (2011) Fetal derived embryonic-like stem cells improve
healing in a large animal flexor tendonitis model. Stem Cell Research & Therapy, 2, 4.
Murine Skin Tissue and Murine Skin Fibroblasts
Wei,J., Melichian,D., Komura,K., Hinchcliff,M., Lam,A.P., Lafyatis,R., Gottardi,C.J., MacDougald,O.A. and Varga,J.
(2011) Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for
scleroderma? Arthritis & Rheumatism, 63, 1707 – 1717.
Rat Hepatic Stellate Cells (HSC-T6)
Weng,T.C., Shen,C.C., Chiu,Y.T., Lin,Y.L. and Huang,Y.T. (2011) Effects of Armepavine Against Hepatic Fibrosis
Induced by Thioacetamide in Rats. Phytotherapy Research doi: 10.1002/ptr.3539.
Human Smooth Muscle and Mesenchymal Stem Cells
Williams,C., Xie,A., Emani,S., Yamato,M., Okano,T., Emani,S.M. and Wong,J. (2011) A comparison of human smooth
muscle and mesenchymal stem cells as potential cell sources for tissue engineered vascular patches. Tissue
Engineering doi: 10.1089/ten.TEA.2011.0172.
Human Fibroblasts
Wong,V.W., Rustad,K.C., Akaishi,S., Sorkin,M., Glotzbach,J.P., Januszyk,M., Nelson,E.R., Levi,K., Paterno,J. and
Vial,I.N. (2011) Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.
Nature Medicine doi: 10.1038/nm.2574.
Fibroblasts
Woon,C.Y.L., Pridgen,B.C., Kraus,A., Bari,S., Pham,H. and Chang,J. (2011) Optimization of Human Tendon Tissue
Engineering: Peracetic Acid Oxidation for Enhanced Reseeding of Acellularized Intrasynovial Tendon. Plastic
and Reconstructive Surgery, 127, 1107.
Bone Marrow Mesenchymal Mononuclear Cells
Wu,W., Allen,R., Gao,J. and Wang,Y. (2011) Artificial Niche Combining Elastomeric Substrate and Platelets Guides
Vascular Differentiation of Bone Marrow Mononuclear Cells. Tissue Engineering Part A, 17, 1979 – 1992.
Macrophages and Whole Tissues
Wynn,T.A., Barron,L., Thompson,R.W., Madala,S.K., Wilson,M.S., Cheever,A.W. and Ramalingam,T. (2011)
Quantitative Assessment of Macrophage Functions in Repair and Fibrosis. Current Protocols in Immunology,
Current Protocols in Immunology, 14, 1-14.
Xu,Z.S., Wang,X.Y., Xiao,D.M., Hu,L.F., Lu,M., Wu,Z.Y. and Bian,J.S. (2011) Hydrogen sulfide protects MC3T3-E1
osteoblastic cells against H2O2-induced oxidative damage-Implication for treatment of osteoporosis. Free
Radical Biology and Medicine, 50, 1314 – 1323.
Murine Monocyte/Macrophage Cell Line (RAW264.7)
Yahyouche,A., Zhidao,X. and Czernuszka,J. (2011) Macrophage-Mediated Degradation of Crosslinked Collagen
Scaffolds. Acta Biomaterialia, 7, 278 – 286.
Murine Lung Tissue
Yamauchi,K., Kasuya,Y., Kuroda,F., Tanaka,K., Tsuyusaki,J., Ishizaki,S., Matsunaga,H., Iwamura,C., Nakayama,T.
and Tatsumi,K. (2011) Attenuation of lung inflammation and fibrosis in CD69-deficient mice after
intratracheal bleomycin. Respiratory Research, 12, 131.
Murine Lung Tissue
Yang,S., Banerjee,S., de Freitas,A., Sanders,Y.Y., Ding,Q., Matalon,S., Thannickal,V.J., Abraham,E. and Liu,G.
(2011) Participation of miR-200 in Pulmonary Fibrosis. The American Journal of Pathology doi:
org/10.1016/j.ajpath.2011.10.005.
Murine Lung Tissue
Young,S.K., Campbell,M., Briones,N., Yamashita,C., Downey,G.P. and Khalifah,A.P. (2011) Protein Tyrosine
Phosphatase- ±Deficiency In Mice Protects Against Bleomycin-Induced Lung Fibrosis And Causes Aberrant
Response To TGF2. Am J Respir Crit Care Med, 183, A6431.
Murine Lung Tissue
Yu,M., Eckart,M.R., Morgan,A.A., Mukai,K., Butte,A.J., Tsai,M. and Galli,S.J. (2011) Identification of an IFN- /mast
cell axis in a mouse model of chronic asthma. J Clin Invest., 121, 3133 – 3143.
Human Fibroblasts
Yun,J.S., Pahk,J.W., Lee,J.S., Shin,W.C., Lee,S.Y. and Hong,E.K. (2011) Inonotus obliquus protects against
oxidative stress-induced apoptosis and premature senescence. Molecules and Cells, 31, 423 – 429.
Zhang,B., Yang,S., Sun,Z., Zhang,Y., Xia,T., Xu,W. and Ye,S. (2011) Human Mesenchymal Stem Cells Induced by
Growth Differentiation Factor 5: An Improved Self-Assembly Tissue Engineering Method for Cartilage Repair.
Tissue Engineering Part C: Methods 17, 1189 – 1199.
Rat Proximal Tubule Cell Line
Zhang,D., Yang,H., Kong,X., Wang,K., Mao,X., Yan,X., Wang,Y., Liu,S., Zhang,X. and Li,J. (2011) Proteomics
analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. American Journal of PhysiologyEndocrinology And Metabolism, 300, E287.
Rat Ventricular Fibroblasts
Zhang,P., Su,J., King,M.E., Maldonado,A.E., Park,C. and Mende,U. (2011) Regulator of G protein signaling 2 is a
functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses. American
Journal of Physiology-Heart and Circulatory Physiology, 301, H147.
Rat Fibroblasts
Zhang,Q., O'Hearn,S., Kavalukas,S.L. and Barbul,A. (2011) Role of High Mobility Group Box 1 (HMGB1) in Wound
Healing. Journal of Surgical Research, doi: 10.1016/j.jss.2011.06.069.
Primary Human Cardiac Fibroblasts
Zhong,H., Belardinelli,L. and Zeng,D. (2011) Pro-Fibrotic Role of the A2B Adenosine Receptor in Human Cardiac
Fibroblasts. Journal of Cardiac Failure, 17, S65.
Human Vocal Fold Fibroblasts
Zhou,H., Felsen,D., Sandulache,V.C., Amin,M.R., Kraus,D.H. and Branski,R.C. (2011) Prostaglandin (PG) E2 exhibits
antifibrotic activity in vocal fold fibroblasts. The Laryngoscope, doi: 10.1002/lary.21795.
Human Vocal Fold Fibroblasts
Zhou,H., Sivasankar,M., Kraus,D.H., Sandulache,V.C., Amin,M. and Branski,R.C. Glucocorticoids regulate
extracellular matrix metabolism in human vocal fold fibroblasts. The Laryngoscope 121, 1915 – 1919.
Murine Lung Tissue
Zhou,Y., Schneider,D.J., Morschl,E., Song,L., Pedroza,M., Karmouty-Quintana,H., Le,T., Sun,C.X. and
Blackburn,M.R. (2011) Distinct Roles for the A2B Adenosine Receptor in Acute and Chronic Stages of
Bleomycin-Induced Lung Injury. The Journal of Immunology, 186, 1097.
2010
Murine Lung Tissue
Ahmad,T., Mabalirajan,U., Hasija,K., Ghosh,B. and Agrawal,A. (2010) Mepacrine treatment attenuates allergic
airway remodeling segregated from airway inflammation in mice. International Immunopharmacology, doi:
10.1016/j.intimp.2010.10.008.
Murine MC3T3-E1 Pre-Osteoblasts
Alford,A.I., Terkhorn,S.P., Reddy,A.B. and Hankenson,K.D. (2010) Thrombospondin-2 regulates matrix
mineralization in MC3T3-E1 pre-osteoblasts. Bone, 46, 464-471.
Murine Fibroblast Cell Line L929
Aramwit,P., Kanokpanont,S., Nakpheng,T. and Srichana,T. (2010) The Effect of Sericin from Various Extraction
Methods on Cell Viability and Collagen Production. Int. J. Mol. Sci. 11, 2200 – 2211.
Bovine Muscle Tissue
Archile-Contreras,A.C. and Purslow,P.P. (2010) Oxidative stress may affect meat quality by interfering with
collagen turnover by muscle fibroblasts. Food Research International, doi: 10.1016/j.foodres.2010.12.002.
Rat Kidney Tissue
Asanuma,H., Vanderbrink,B.A., Campbell,M.T., Hile,K.L., Zhang,H., Meldrum,D.R. and Meldrum,K.K. (2010)
Arterially Delivered Mesenchymal Stem Cells Prevent Obstruction-Induced Renal Fibrosis. Journal of
Surgical Research, doi: 10.1016/j.jss.2010.06.022.
Mammalian Articular Cartilage
Bae,J.Y., Han,D.W., Matsumura,K., Wakitani,S., Nawata,M. and Hyon,S.H. (2010) Nonfrozen Preservation of
Articular Cartilage by Epigallocatechin-3-Gallate Reversibly Regulating Cell Cycle and NF- κB Expression.
Tissue Engineering Part A, 16, 595.
Murine Lung Dendritic Cells
Bantsimba-Malanda,C., Marchal-Somme,J., Goven,D., Freynet,O., Michel,L., Crestani,B. and Soler,P. (2010) A Role
for Dendritic Cells in Bleomycin-induced Pulmonary Fibrosis in Mice? American Journal of Respiratory and
Critical Care Medicine, 182, 385 - 395.
Human Fibroblasts
Bendersky,A., Markovits,N. and Bank,I. (2010) V γ9+γδT cells in systemic sclerosis patients are numerically and
functionally preserved and induce fibroblast apoptosis. Immunobiology, 215, 380-394.
Human Skin Samples
Boisnic,S. and Branchet,M.C. (2010) Ex vivo study of the home-use TriPollar RF device using an experimental human
skin model. Journal of Dermatological Treatment, 21, 301 - 335.
Human Gingival Tissue
Boisnic,S., Ben Slama,L. and Branchet-Gumila,M.C. (2010) Comparaison de l'effet anti-inflammatoire et rparateur
de deux dentifrices sur un mod le exprimental de muqueuse gingivale humaine. Revue de Stomatologie et
de Chirurgie Maxillo-faciale, 111, 291 – 295.
Murine Lung Tissue
Busse,P.J., Schofield,B., Birmingham,N., Yang,N., Wen,M.C., Zhang,T.F., Srivastava,K. and Li,X.M. (2010) The
traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and
antigen-challenged aged mice. Annals of Allergy, Asthma & Immunology, 104, 236-246.
Rat Lung Tissue
Calveley,V.L., Jelveh,S., Langan,A., Mahmood,J., Yeung,I.W.T., Van Dyk,J. and Hill,R.P. (2010) Genistein Can
Mitigate the Effect of Radiation on Rat Lung Tissue. Radiation Research, 173, 602-611.
Cao,S., Yaqoob,U., Das,A., Shergill,U., Jagavelu,K., Huebert,R.C., Routray,C., Abdelmoneim,S., Vasdev,M. and
Leof,E. (2010) Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF- β
signaling in hepatic stellate cells. J Clin Invest. 120, 2379–2394.
Murine Dorsal Tissue
Chang,P.J., Chen,M.Y., Huang,Y.S., Lee,C.H., Huang,C.C., Lam,C.F. and Tsai,Y.C. (2010) Morphine enhances tissue
content of collagen and increases wound tensile strength. Journal of Anesthesia, 24, 240-246.
Hepatic Stellate Cells (HSC-T6)
Chen,B.Y., Qu,P., Tie,R., Zhu,M.Z., Zhu,X.X. and Yu,J. (2010) Protecting effects of vasonatrin peptide against
carbon tetrachloride-induced liver fibrosis. Regulatory Peptides, 164, 139 – 143.
Cheng,H., Luk,K.D.K., Cheung,K. and Chan,B.P. (2010) In vitro generation of an osteochondral interface from
mesenchymal stem cell-collagen microspheres. Biomaterials, 32, 1526 – 1535.
Murine Aorta
Cheng,S.L., Shao,J.S., Halstead,L.R., Distelhorst,K., Sierra,O. and Towler,D.A. (2010) Activation of Vascular Smooth
Muscle Parathyroid Hormone Receptor Inhibits Wnt/β-Catenin Signaling and Aortic Fibrosis in Diabetic
Arteriosclerosis. Circulation research, 107, 271 – 282.
Fibroblasts
Chiang,H.M., Lin,T.J., Chiu,C.Y., Chang,C.W., Hsu,K.C., Fan,P.C. and Wen,K.C. (2010) Coffea arabica extract and
its constituents prevent photoaging by suppressing MMPs expression and MAPK pathway. Food and Chemical
Toxicology, 49, 309 – 318.
Human Fibroblasts
Choi,H., Kim,D., Kim,J.W., Ngadiran,S., Sarmidi,M.R. and Park,C.S. (2010) Labisia pumila extract protects skin cells
from photoaging caused by UVB irradiation. Journal of Bioscience and Bioengineering, 109, 291-296.
Rat Liver Tissue
Choi,J.H., Hwang,Y.P., Choi,C.Y., Chung,Y.C. and Jeong,H.G. (2010) Anti-fibrotic effects of the anthocyanins
isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine
administration in rats. Food and Chemical Toxicology, 48, 3137 - 3143.
Human Tenon's Fibroblasts
Choritz,L., Grub,J., Wegner,M., Pfeiffer,N. and Thieme,H. (2010) Paclitaxel inhibits growth, migration and collagen
production of human Tenon's fibroblastsùpotential use in drug-eluting glaucoma drainage devices. Graefe's
Archive for Clinical and Experimental Ophthalmology, 248, 197-206.
Bovine Thoracic Aortic Tissue
Chow,M.J. and Zhang,Y. (2010) The Change in Mechanical and Biochemical Properties of Aortic Tissue Due to Cold
Storage. Journal of Surgical Research, doi:10.1016/j.jss.2010.04.007.
Fetal Cardiac Fibroblasts
Clancy,R.M., Alvarez,D., Komissarova,E., Barrat,F.J., Swartz,J. and Buyon,J.P. (2010) Ro60-Associated SingleStranded RNA Links Inflammation with Fetal Cardiac Fibrosis via Ligation of TLRs: A Novel Pathway to
Autoimmune-Associated Heart Block. The Journal of Immunology, 184, 2148.
Murine Lung Tissue
Cowden,J.M., Riley,J.P., Ma,J.Y., Thurmond,R.L. and Dunford,P.J. (2010) Histamine H 4 receptor antagonism
diminishes existing airway inflammation and dysfunction via modulation of Th 2 cytokines. Respiratory
Research, 11, 86.
Murine Tail Tissue
Damodarasamy,M., Vernon,R.B., Karres,N., Chang,C.H., Bianchi-Frias,D., Nelson,P.S. and Reed,M.J. (2010) Collagen
Extracts Derived from Young and Aged Mice Demonstrate Different Structural Properties and Cellular Effects
in Three-Dimensional Gels. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences,
Series A, 65, 209 - 218.
Rat Bone Marrow Mesenchymal Stem Cells
de Melo Ocarino,N., Boeloni,J.N., Jorgetti,V., Gomes,D.A., Goes,A.M. and Serakides,R. (2010) Intra-bone marrow
injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats. Connective
Tissue Research, 51, 426 - 433.
Murine Model of Scleroderma
Derrett-Smith,E., Dooley,A., Khan,K., Shi-wen,X., Abraham,D. and Denton,C. (2010) Systemic vasculopathy with
altered vasoreactivity in a transgenic mouse model of scleroderma. Arthritis Research & Therapy, 12, R69.
Human Oral Submucosal Tissue
Dhariwal,R. and Mukherjee,S. (2010) Zinc and vitamin A can minimise the severity of oral submucous fibrosis. (2010)
BMJ Case Reports, doi:10.1136/bcr.10.2009.2348.
Rat Neonatal Calvarial Osteoblasts
Dias,R.C.M., Góes,A.M., Serakides,R., Ayres,E. and Oréfice,R.L. (2010) Porous biodegradable polyurethane
nanocomposites: preparation, characterization, and biocompatibility tests. Materials Research, 13, 211218.
Lung Fibroblast Cells
Du,X., Jiang,S., Liu,H., Xin,X., Li,J., Geng,M. and Jiang,H. (2010) MS80, a novel sulfated polysaccharide, inhibits
CD40-NF- B pathway via targeting RIP2. Molecular and Cellular Biochemistry, 337, 277-285.
Human Dermal Tissue
Eberli,D., Rodriguez,S., Atala,A. and Yoo,J.J. (2010) In vivo evaluation of acellular human dermis for abdominal
wall repair. Journal of Biomedical Materials Research Part A, 93, 1527-1538.
Murine Lung Tissue
Ekstrand-Hammarström,B., Wigenstam,E. and Bucht,A. (2010) Inhalation of alkylating mustard causes long-term T
cell-dependent inflammation in airways and growth of connective tissue. Toxicology, doi:
10.1016/j.tox.2010.11.012.
Murine Retinal Pigment Epithelial Cells
Elliot,S.J., Catanuto,P., Espinosa-Heidmann,D.G., Fernandez,P., Hernandez,E., Saloupis,P., Korach,K., Karl,M. and
Cousins,S.W. (2010) Estrogen receptor β protects against in vivo injury in RPE cells. Experimental eye
research, 90, 10-16.
Human Anterior Cruciate Ligament (ACL) Cells
Fallouh,L., Nakagawa,K., Sasho,T., Arai,M., Kitahara,S., Wada,Y., Moriya,H. and Takahashi,K. (2010) Effects of
Autologous Platelet-Rich Plasma on Cell Viability and Collagen Synthesis in Injured Human Anterior Cruciate
Ligament. The Journal of Bone and Joint Surgery, 92, 2909 – 2916.
Bronchial Epithelial Cell Line RL-65
Felton,V.M., Inge,L.J., Willis,B.C., Bremner,R.M. and Smith,M.A. (2010) Immunosuppression-induced bronchial
epithelial-mesenchymal transition: A potential contributor to obliterative bronchiolitis. The Journal of
Thoracic and Cardiovascular Surgery, doi: 10.1016/j.jtcvs.2010.10.006.
Murine Lung Tissue
Fukumoto,J., Harada,C., Kawaguchi,T., Suetsugu,S., Maeyama,T., Inoshima,I., Hamada,N., Kuwano,K. and
Nakanishi,Y. (2010) Amphiregulin attenuates bleomycin-induced pneumopathy in mice. American Journal of
Physiology- Lung Cellular and Molecular Physiology, 298, L131 – L138.
Fibrocytes
Garcia-de-Alba,C., Becerril,C., Ruiz,V., Gonzalez,Y., Reyes,S., Garcia-Alvarez,J., Selman,M. and Pardo,A. (2010)
Expression of Matrix Metalloproteases by Fibrocytes. Possible Role in Migration and Homing. American
Journal of Respiratory and Critical Care Medicine,182, 1144 –1152.
Murine Lung Tissue
García-Prieto,E., González-López,A., Cabrera,S., Astudillo,A., Gutiérrez-Fernández,A., Fanjul-Fernandez,M.,
Batalla-Solís,E., Puente,X.S., Fueyo,A. and López-Otín,C. (2010) Resistance to Bleomycin-Induced Lung
Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10. PloS one, 5, 835-839.
Lung Tissue
Garibaldi,B.T., D'Alessio,F.R., Files,D.C., Chau,E., Sidhaye,V., Fraig,M. and King,L.S. (2010) Regulatory Tlymphocytes Play A Key Role In The Fibroproliferative Response To Acute Lung Injury. American Journal of
Murine Lung Tissue
Gill,S.E., Huizar,I., Bench,E.M., Sussman,S.W., Wang,Y., Khokha,R. and Parks,W.C. (2010) Tissue Inhibitor of
Metalloproteinases 3 Regulates Resolution of Inflammation following Acute Lung Injury. American Journal
of Pathology, 176, 64.
Human Mesenchymal Stromal Cells from Adipose Tissue
Giusta,M.S., Andrade,H., Santos,A.V., Castanheira,P., Lamana,L., Pimenta,A.M.C. and Goes,A.M. (2010) Proteomic
analysis of human mesenchymal stromal cells derived from adipose tissue undergoing osteoblast
differentiation. Cytotherapy, 12, 478-490.
Murine Airway Epithelial Tissue
Gregory,L.G., Mathie,S.A., Walker,S.A., Pegorier,S., Jones,C.P. and Lloyd,C.M. (2010) Overexpression of SMAD2
Drives House Dust Mite- Mediated Airway Remodeling and Airway Hyperresponsiveness via Activin and Il-25.
American Journal of Respiratory and Critical Care Medicine, 182, 143.
Lung Tissue
Hardie,W., LeCras,T., Korfhagen,T., Davidson,C., Schmidt,S., Ikegami,M. and Whitsett,J.A. (2010) Inhibition Of
PI3K Reverses Transforming Growth Factor-alpha Induced Pulmonary Fibrosis. American Journal of
Human Hepatic Stellate Cell Line (LX-2)
Hasegawa,D., Fujii,R., Yagishita,N., Matsumoto,N., Aratani,S., Izumi,T., Azakami,K., Nakazawa,M., Fujita,H. and
Sato,T. (2010) E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis. PloS one, 5, 209-218.
Rat Model for Abdominal Wall Replacement
Hashizume,R., Fujimoto,K.L., Hong,Y., Amoroso,N.J., Tobita,K., Miki,T., Keller,B.B., Sacks,M.S. and Wagner,W.R.
(2010) Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use
of a wet electrospun biodegradable polyurethane elastomer scaffold. Biomaterials, 31, 3253 – 3265.
Inner Annulus Fibrosus (AF) and Nucleus Pulposus (NP) Tissues
Hee,H.T., Zhang,J. and Wong,H.K. (2010) Effects of cyclic dynamic tensile strain on previously compressed inner
annulus fibrosus and nucleus pulposus cells of human intervertebral disc-an in vitro study. Journal of
Orthopaedic Research, 28, 503-509.
Human Inner Annulus Fibrosus (AF) and Nucleus Pulposus (NP) Cells.
Hee,H.T., Zhang,J. and Wong,H.K. (2010) An in vitro study of dynamic cyclic compressive stress on human inner
annulus fibrosus and nucleus pulposus cells. The Spine Journal, 10, 795 – 801.
Human Smooth Muscle Cells Derived From Neurogenic Bladders
Hodges,S.J., Yoo,J.J., Mishra,N. and Atala,A. (2010) The Effect of Epigenetic Therapy on Congenital Neurogenic
Bladders - A Pilot Study. Urology, 75, 868 – 872.
Murine Colon, Liver and Lung Tissue
Hunter,M.M., Wang,A., Parhar,K.S., Johnston,M.J.G., van Rooijen,N., Beck,P.L. and McKay,D.M. (2010) In vitroderived alternatively activated macrophages reduce colonic inflammation in mice. Gastroenterology, 138,
1395-1405.
Rat Bone Marrow Stromal Cells (MSC) and MC3T3-E1 Cells
Ichinohe,N., Nakano,T., Mitaka,T., Umakoshi,Y. and Tabata,Y. (2010) Proliferation and osteogenic differentiation of
rat bone marrow stromal cells on bioapatite with different crystalline facets. Journal of Biomedical
Materials Research Part A, 93, 646-655.
Rat Achilles Tendon Fibroblasts
Irie,T., Takahata,M., Majima,T., Abe,Y., Komatsu,M., Iwasaki,N. and Minami,A. (2010) Effect of selective estrogen
receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast.
Connective Tissue Research, 51, 179-187.
Murine Achilles and Tail Tendons
Ito,Y., Toriuchi,N., Yoshitaka,T., Ueno-Kudoh,H., Sato,T., Yokoyama,S., Nishida,K., Akimoto,T., Takahashi,M. and
Miyaki,S. (2010) The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proceedings
of the National Academy of Sciences, 107, 10538.
Hepatocellular Carcinoma Cell Lines
Ji,J., Zhao,L., Budhu,A., Forgues,M., Jia,H.L., Qin,L.X., Ye,Q.H., Yu,J., Shi,X. and Tang,Z.Y. (2010) Let-7g targets
collagen type I α2 and inhibits cell migration in hepatocellular carcinoma. Journal of Hepatology, 52, 690 697.
Primary Human Lung Fibroblasts
Jones,B., Bucks,C., Wilkinson,P., Pratta,M., Farrell,F. and Sivakumar,P. (2010) Development of Cell Based
Immunoassays to Measure Type I Collagen in Cultured Fibroblasts. The International Journal of Biochemistry
& Cell Biology, 42, 1808 – 1815.
Kalfa,D., Bel,A., Chen-Tournoux,A., la Martina,A., Rochereau,P., Coz,C., Bellamy,V., Bensalah,M., Vanneaux,V. and
Lecourt,S. (2010) A polydioxanone electrospun valved patch to replace the right ventricular outflow tract in
a growing lamb model. Biomaterials, 31, 4056 – 4063.
Rat Renal Cells
Kang,Y.S., Song,H.K., Lee,M.H., Ko,G.J., Han,J.Y., Han,S.Y., Han,K.H., Kim,H.K. and Cha,D.R. (2010) Visfatin is
upregulated in type-2 diabetic rats and targets renal cells. Kidney International, 78, 170-181.
Murine Skin Tissue
Kanno,Y., Kawashita,E., Minamida,M., Kaneiwa,A., Okada,K., Ueshima,S., Matsuo,O. and Matsuno,H. (2010) α2Antiplasmin Is Associated with the Progression of Fibrosis. American Journal of Pathology, 176, 238.
Murine and Human Skin and Lung Tissue
Kavian,N., Servettaz,A., Mongaret,C., Wang,A., Nicco,C., Chéreau,C., Grange,P., Vuiblet,V., Birembaut,P. and
Diebold,M.D. (2010) Targeting ADAM17-Notch signalling abrogates the development of systemic sclerosis in a
murine model. Arthritis Rheum., 62, 3477 - 3487.
Murine Skin Tissue
Kawada,S., Ohtani,M. and Ishii,N. (2010) Increased oxygen tension attenuates acute ultraviolet-B-induced skin
angiogenesis and wrinkle formation. American Journal of Physiology- Regulatory, Integrative and
Comparative Physiology, 299, R694 – R701.
Murine Lung Tissue
Kearley,J., Erjefalt,J.S., Andersson,C., Benjamin,E., Jones,C.P., Robichaud,A., Pegorier,S., Brewah,Y.,
Burwell,T.J. and Bjermer,L. (2010) IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and
Chronic Remodeling of the Airways. American Journal of Respiratory and Critical Care Medicine, doi:
10.1164/rccm.200909-1462OC.
Fibrocytes
Keeley,E.C., Mehrad,B. and Strieter,R.M. (2010) The Role of Fibrocytes in Lung Repair and Fibrosis. Stem Cells in
the Respiratory System, doi:10.1007/978-1-60761-775-4_4.
Human Osteoarticular Cartilages and Chondrocytes
Kim,J.H., Huh,J.E., Baek,Y.H., Lee,J.D., Choi,D.Y. and Park,D.S. (2010) Effect of Phellodendron amurense in
protecting human osteoarthritic cartilage and chondrocytes. Journal of Ethnopharmacology, doi:
10.1016/j.jep.2010.12.005.
Murine Lung Tissue
Kim,J.S., Kim,D.Y., Lee,J.K., Ro,J.Y. and Chung,M.H. (2010) 8-oxo-2'-deoxyguanosine suppresses allergy-induced
lung tissue remodeling in mice. European Journal of Pharmacology, 651, 218 – 226.
Murine Lung Tissue
Kim,T.H., Lee,Y.H., Kim,K.H., Lee,S.H., Cha,J.Y., Shin,E.K., Jung,S., Jang,A.S., Park,S.W. and Uh,S.T. (2010) Role
of Lung Apolipoprotein A1 in Idiopathic Pulmonary Fibrosis: Anti-inflammatory and Anti-fibrotic Effect on
Experimental Lung Injury/Fibrosis. American Journal of Respiratory and Critical Care Medicine, 182, 633 642.
Murine Embryonic Fibroblast Cell Line (NIH-3T3 Cells) and Primary Colonic Myofibroblasts
Kitamura,H., Yamamoto,S., Nakase,H., Matsuura,M., Honzawa,Y., Matsumura,K., Takeda,Y., Uza,N., Nagata,K. and
Chiba,T. (2010) Role of Heat Shock Protein 47 in Intestinal Fibrosis of Experimental Colitis. Biochemical and
Biophysical Research Communications, doi: 10.1016/j.bbrc.2010.12.006.
Fibroblast Cells
Klass,B.R., Branford,O.A., Grobbelaar,A.O. and Rolfe,K.J. (2010) The effect of epigallocatechin-3-gallate, a
constituent of green tea, on transforming growth factor- ß1-stimulated wound contraction. Wound Repair
and Regeneration, 18, 80-88.
Murine Lung Fibroblasts
Kohan,M., Muro,A.F., Bader,R. and Berkman,N. (2010) The extra domain A of fibronectin is essential for allergeninduced airway fibrosis and hyperresponsiveness in mice. Journal of Allergy and Clinical Immunology, doi:
10.1016/j.jaci.2010.10.021.
Kohan,M., Puxeddu,I., Reich,R., Levi-Schaffer,F. and Berkman,N. (2010) Eotaxin-2/CCL24 and eotaxin-3/CCL26
exert differential profibrogenic effects on human lung fibroblasts. Annals of Allergy, Asthma &
Primary Lung Fibroblasts
Kohan,M., Muro,A.F., White,E.S. and Berkman,N. (2010) EDA-containing cellular fibronectin induces fibroblast
differentiation through binding to α4 ß7 integrin receptor and MAPK/Erk 1/2-dependent signaling. The
FASEB Journal, 24, 4503 - 4512.
Rat Lung Tissue
Kohno,M., Haramoto,M., Nakajima,O., Yang,L., Hinotsu,S., Yokohira,M., Imaida,K. and Kawakami,K. (2010)
Antedrug Budesonide by Intrapulmonary Treatment Attenuates Bleomycin-Induced Lung Injury in Rats with
Minimal Systemic Adverse Effects. Biological & Pharmaceutical Bulletin, 33, 1206-1211.
Murine Lung Tissue
Königshoff,M., Dumitrascu,R., Udalov,S., Amarie,O.V., Reiter,R., Grimminger,F., Seeger,W., Schermuly,R.T. and
Eickelberg,O. (2010) Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary
fibrosis: a rationale for therapeutic intervention. Thorax, doi:10.1136/thx.2009.134353.
Murine embryo Fibroblast Cell Line (NIH-3T3)
Kramer,M. (2010) The WNT/beta-catenin pathway: Profibrotic signaling in fibroblasts in Idiopathic Pulmonary
Fibrosis. http://geb.uni-giessen.de/geb/volltexte/2010/7829.
Murine Lung Tissue
Krishnaveni,M., Li,C., Borok,Z., Minoo,P. and Li,M. (2010) Epithelial-Specific Deletion Of Transforming Growth
Factor- (TGF- ) Receptor Type II (T RII) In The Lung Confers Relative Resistance To Bleomycin Injury. Am J
Respir Crit Care Med, 181, A3525.
Murine Chondrocytic Cell Line
Kushibiki,T., Tajiri,T., Ninomiya,Y. and Awazu,K. (2010) Chondrogenic mRNA expression in prechondrogenic cells
after blue laser irradiation. Journal of Photochemistry and Photobiology B: Biology, 98, 211 – 215.
Murine and Human Lung Fibroblasts (MRC-5)
Lang,Y.D., Chang,S.F., Wang,L.F. and Chen,C.M. (2010) Chymase mediates paraquat-induced collagen production in
human lung fibroblasts. Toxicology letters, 193, 19-25.
Lang,Y.D., Hung,C.L., Wu,T.Y., Wang,L.F. and Chen,C.M. (2010) The renin-angiotensin system mediates hyperoxiainduced collagen production in human lung fibroblasts. Free Radical Biology and Medicine, 1,88-95.
Human Embryonic Lung Fibroblasts (WI-38 Cell Line) and Human Keloid Cadaveric Skin Tissues
Lareu,R.R., Zeugolis,D.I., bu-Rub,M., Pandit,A. and Raghunath,M. (2010) Essential modification of the Sircol
Collagen Assay for the accurate quantification of collagen content in complex protein solutions. Acta
biomaterialia, 6, 3146 – 3151.
Murine Brain Capillary Endothelial Cells
Lecht,S., rien-Zakay,H., Kohan,M., Lelkes,P.I. and Lazarovici,P. (2010) Angiostatic effects of K252a, a Trk inhibitor,
in murine brain capillary endothelial cells. Molecular and Cellular Biochemistry, 339, 201-213.
Murine Lung Tissue
Le Cras,T.D., Korfhagen,T.R., Davidson,C., Schmidt,S., Fenchel,M., Ikegami,M., Whitsett,J.A. and Hardie,W.D.
(2010) Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α-Induced Pulmonary Fibrosis.
American Journal of Pathology, 176, 679 - 686.
Ligament-Bone (LTB) Relevant Cells
Lee,J., Choi,W.I., Tae,G., Kim,Y.H., Kang,S.S., Kim,S.E., Kim,S.H., Jung,Y. and Kim,S.H. (2011) Enhanced
regeneration of poly (L-lactide-co-ε-caprolactone) scaffold to ligament-to-bone interface by local delivery
of cells/BMP-2 using a heparin-based hydrogel. Acta Biomaterialia, 7, 244 – 257.
Bone Marrow Derived Mesenchymal Stem Cells
Lee,S.H., Jang,A.S., Kim,Y.E., Cha,J.Y., Kim,T.H., Jung,S., Park,S.K., Lee,Y.K., Won,J.H. and Kim,Y.H. (2010)
Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis. Resp.
Res. 11, 16.
Murine Lung Tissue
Liu,G., Friggeri,A., Yang,Y., Milosevic,J., Ding,Q., Thannickal,V.J., Kaminski,N. and Abraham,E. (2010) miR-21
mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. The Journal of experimental
medicine, 207, 1589.
Lung Tissue
Li,M., Krishnaveni,M.S., Li,C., Borok,Z. and Minoo,P. (2010) Epithelial-Specific Deletion Of Transforming Growth
Factor-2 TGF2) Receptor Type II (T2RII) In The Lung Confers Relative Resistance To Bleomycin Injury.
Fibroblasts and Connective Tissue
Lin,Y.K. and Kuan,C.Y. (2010) Development of 4-hydroxyproline analysis kit and its application to collagen
quantification. Food Chemistry, 119, 1271-1277.
Porcine Chondrocytes and Osteoblasts
Lin,Y.Y., Tanaka,N., Ohkuma,S., Iwabuchi,Y., Tanne,Y., Kamiya,T., Kunimatsu,R., Huang,Y.C., Yoshioka,M. and
Mitsuyoshi,T. (2010) Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on
chondrocytes in a co-culture system. European Journal of Oral Sciences, 118, 151-158.
Murine Lung Tissue
Liu,X., Li,F., Sun,S.Q., Thangavel,M., Kaminsky,J., Balazs,L. and Ostrom,R.S. (2010) Fibroblast specific expression
of AC6 enhances ss-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.
American Journal of Physiology- Lung Cellular and Molecular Physiology,298, L819 – L829.
Murine Lung Tissue and Fibroblasts
Liu,F., Mih,J.D., Shea,B.S., Kho,A.T., Sharif,A.S., Tager,A.M. and Tschumperlin,D.J. (2010) Feedback amplification
of fibrosis through matrix stiffening and COX-2 suppression. The Journal of Cell Biology, 190, 693 – 706.
Murine Lung Tissue
Lo Re,S., Dumoutier,L., Couillin,I., Van Vyve,C., Yakoub,Y., Uwambayinema,F., Marien,B., van den Brûle,S., Van
Snick,J. and Uyttenhove,C. (2010) IL-17A-Producing γδ T and Th17 Lymphocytes Mediate Lung Inflammation
but Not Fibrosis in Experimental Silicosis. The Journal of Immunology, 184, 6367.
Osteoblastic Cell Cultures
Lozano,D., Manzano,M., Doadrio,J.C., Salinas,A.J., Vallet-RegíM., Gómez-Barrena,E. and Esbrit,P. (2010)
Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomaterialia, 6,
797-803.
Lu,H.K., Tseng,C.C., Lee,Y.H., Li,C.L. and Wang,L.F. (2010) Flutamide inhibits nifedipine-and interleukin-1 induced collagen overproduction in gingival fibroblasts. Journal of Periodontal Research, 45, 451 - 457.
Rat Aortic Endothelial Cells and Rat Aortic Smooth Muscle Cells
Lu,J., Khang,D. and Webster,T.J. (2010) Greater endothelial cell responses on submicron and nanometer rough
titanium surfaces. Journal of Biomedical Materials Research Part A, 94, 1042-1049.
Lu,Y., Azad,N., Wang,L., Iyer,A.K.V., Castranova,V., Jiang,B-H. and Rojanasakul,Y. (2010) Phosphatidylinositol-3Kinase/Akt Regulates Bleomycin-Induced Fibroblast Proliferation and Collagen Production. American
Journal of Respiratory Cell and Molecular Biology, 42, 432 – 441.
Ma,Y., Guan,Q., Bai,A., Weiss,C.R., Hillman,C.L., Ma,A., Zhou,G., Qing,G. and Peng,Z. (2010) Targeting TGF- ß1 by
employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis. Inflammatory Bowel Diseases,
16, 1040-1050.
Lung Tissue
McDonald,J., Wright,M.R., Wright,C.D., Kuehl,P.J., Duncan,M. and Doyle-Eisele,M. (2010) GS-9450 A Novel Caspase
Inhibitor Provides Protection Against Bleomycin Induced Pulmonary Fibrosis By Inhibition Of Apoptosis.
Murine Colon Extracts
Melon,A. and Wang,A. (2010) Infection with Hymenolepis diminuta Is More Effective than Daily Corticosteroids in
Blocking Chemically Induced Colitis in Mice. J Biomed Biotechnol., 2010, 384523.
Pancreatic Stellate Cells
Morishita,K., Shimizu,K., Haruta,I., Kawamura,S., Kobayashi,M. and Shiratori,K. (2010) Engulfment of Gram-Positive
Bacteria by Pancreatic Stellate Cells in Pancreatic Fibrosis. Pancreas, 39, 1002 – 1007.
Murine Lung Tissue
Murray,L.A., Chen,Q., Kramer,M.S., Hesson,D.P., Argentieri,R.L., Peng,X., Gulati,M., Homer,R.J., Russell,T. and
van Rooijen,N. (2010) TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum
amyloid P. The International Journal of Biochemistry & Cell Biology, 43, 154 – 162.
Developing Tissue Engineered Cartilage Constructs
Natoli,R.M., Skaalure,S., Bijlani,S., Chen,K.X., Hu,J. and Athanasiou,K.A. (2010) Intracellular Na+ and Ca2+
modulation increases the tensile properties of developing engineered articular cartilage. Arthritis &
Rheumatism, 62, 1097-1107.
Human and Murine Lung Tissue
Odajima,N., Betsuyaku,T., Nagai,K., Moriyama,C., Wang,D.H., Takigawa,T., Ogino,K., Nishimura,M., Xu,D.Q. and
Luo,Y. (2010) The role of Catalase in Pulmonary Fibrosis. Respiratory Research, 11, 183.
Murine Lung Tissue
Ohbayashi,M., Suzuki,M., Yashiro,Y., Fukuwaka,S., Yasuda,M., Kohyama,N., Kobayashi,Y. and Yamamoto,T. (2010)
Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro. The Journal of
Toxicological Sciences, 35, 653-661.
Park,H.H., Cho,J.S., Park,I.H., Kim,Y.D. and Lee,H.M. (2010) The Effect Of Macrolides On Myofibroblast
Differentiation And Collagen Production In Nasal Polyp-Derived Fibroblasts. American Journal of Respiratory
and Critical Care Medicine, 181, A4213.
Park,H.H., Park,I.H., Cho,J.S., Lee,Y.M. and Lee,H.M. (2010) The effect of macrolides on myofibroblast
differentiation and collagen production in nasal polyp-derived fibroblasts. American Journal of Rhinology &
Allergy, 24, 348-353.
Murine MC3T3-E1 Calvarial Preosteoblasts
Pedraza,C.E., Marelli,B., Chicatun,F., McKee,M.D. and Nazhat,S.N. (2010) An In Vitro Assessment of a CellContaining Collagenous Extracellular Matrix-like Scaffold for Bone Tissue Engineering. Tissue Engineering
Part A, 16, 781.
Pegorier,S., Campbell,G.A., Kay,A.B. and Lloyd,C.M. (2010) Bone Morphogenetic Protein (BMP)-4 and BMP-7
regulate differentially Transforming Growth Factor (TGF)-ß1 in normal human lung fibroblasts (NHLF).
Respir Res. 2010; 11, 85.
Murine Lung Tissue
Phillips,J.E., Anand,M. and Chapman,R.W. (2010) Combined Cigarette Smoke And Viral Challenge Produces
Synergistic Effects On Mouse Pulmonary Pathology. American Journal of Respiratory and Critical Care
Pereira,I.H.L., Ayres,E., Patrício,P.S., Góes,G., Gomide,V.S., Junior,E.P. and Or éfice,R.L. (2010)
Photopolymerizable and injectable polyurethanes for biomedical applications: synthesis and
biocompatibility. Acta Biomaterialia, 6, 3056 - 3066.
Bone Marrow Derived Mesenchymal Stem Cells
Ramaswamy,S., Gottlieb,D., Engelmayr Jr,G.C., Aikawa,E., Schmidt,D.E., Gaitan-Leon,D.M., Sales,V.L., Mayer
Jr,J.E. and Sacks,M.S. (2010) The role of organ level conditioning on the promotion of engineered heart
valve tissue development in-vitro using mesenchymal stem cells. Biomaterials, 31, 1114-1125.
Murine Skin Tissue
Rankin,A.L., Mumm,J.B., Murphy,E., Turner,S., Yu,N., McClanahan,T.K., Bourne,P.A., Pierce,R.H., Kastelein,R. and
Pflanz,S. (2010) IL-33 Induces IL-13-Dependent Cutaneous Fibrosis. The Journal of Immunology, 184, 1526.
Collagen Gels and Cellularized (Normal Human Lung Fibroblasts) Collagen Gels
Raub,C.B., Putnam,A.J., Tromberg,B.J. and George,S.C. (2010) Predicting bulk mechanical properties of
cellularized collagen gels using multiphoton microscopy. Acta Biomaterialia, 6, 4657 - 4665.
Murine Fibroblasts
Reich,N., Maurer,B., Akhmetshina,A., Venalis,P., Dees,C., Zerr,P., Palumbo,K., Zwerina,J., Nevskaya,T. and Gay,S.
(2010) The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis.
Arthritis & Rheumatism, 62, 280-290.
Murine Lung Tissue
Riteau,N., Gasse,P., Fauconnier,L., Gombault,A., Couegnat,M., Fick,L., Kanellopoulos,J., Quesniaux,V.F.J.,
Marchand-Adam,S. and Crestani,B. (2010) Extracellular ATP is a Danger Signal Activating P2X7 Receptor in
Lung Inflammation and Fibrosis. American Journal of Respiratory and Critical Care Medicine, 182, 774 783.
Murine Lung Tissue
Ryu,J., Heldt,G.P., Nguyen,M., Gavrialov,O. and Haddad,G.G. (2010) Chronic hypercapnia alters lung matrix
composition in mouse pups. Journal of Applied Physiology, 109, 203.
Rabbit Bone Marrow Stem Cells
Sahoo,S., Ang,L.T., Goh,J.C.H. and Toh,S.L. (2010) Bioactive nanofibers for fibroblastic differentiation of
mesenchymal precursor cells for ligament/tendon tissue engineering applications. Differentiation, 79, 102110.
Biohybrid Scaffold Containing Mesenchymal Progenitor Cells
Sahoo,S., Toh,S.L. and Goh,J.C.H. (2010) A bFGF-releasing silk/PLGA-based biohybrid scaffold for ligament/tendon
tissue engineering using mesenchymal progenitor cells. Biomaterials, 31, 2990 – 2998.
Bone Marrow Stem Cells
Sahoo,S., Ang,L.T., Goh,J.C.H. and Toh,S.L. (2010) Growth factor delivery through electrospun nanofibers in
scaffolds for tissue engineering applications. Journal of Biomedical Materials Research Part A, 93, 15391550.
Ovine Peripheral Blood Endothelial Progenitor Cells
Sales,V.L., Mettler,B.A., Engelmayr Jr,G.C., Aikawa,E., Bischoff,J., Martin,D.P., Exarhopoulos,A., Moses,M.A.,
Schoen,F.J. and Sacks,M.S. (2010) Endothelial Progenitor Cells as a Sole Source for Ex Vivo Seeding of
Tissue-Engineered Heart Valves. Tissue Engineering Part A, 16, 257.
Rabbit Patella Tendon Fibroblasts
Sawaguchi,N., Majima,T., Funakoshi,T., Shimode,K., Harada,K., Minami,A. and Nishimura,S.I. (2010) Effect of
cyclic three-dimensional strain on cell proliferation and collagen synthesis of fibroblast-seeded chitosanhyaluronan hybrid polymer fiber. Journal of Orthopaedic Science, 15, 569-577.
Murine Equine Suspensory Ligament
Schnabel,L.V., Mohammed,H.O., Jacobson,M.S. and Fortier,L.A. (2010) Effects of platelet rich plasma and acellular
bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures.
Equine Veterinary Journal, 40, 260-265.
Bronchiolar Lavage Fluid
Schneider,D.J., Lindsay,J.C., Zhou,Y., Molina,J.G. and Blackburn,M.R. (2010) Adenosine and osteopontin contribute
to the development of chronic obstructive pulmonary disease. The FASEB Journal, 24, 70.
Murine Lung Tissue
Schütze,N., Lehmann,I., Bonisch,U., Simon,J.C. and Polte,T. (2010) Exposure to Mycotoxins Increases the Allergic
Immune Response in a Murine Asthma Model. American Journal of Respiratory and Critical Care Medicine,
181, 1188 – 1199.
Human Lung Tissue
Senoo,T., Hattori,N., Tanimoto,T., Furonaka,M., Ishikawa,N., Fujitaka,K., Haruta,Y., Murai,H., Yokoyama,A. and
Kohno,N. (2010) Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary
fibrosis. British Medical Journal, 65, 334.
Human Fibroblasts
Seo,Y.K., Jung,S.H., Song,K.Y., Park,J.K. and Park,C.S. (2010) Anti-photoaging effect of fermented rice bran
extract on UV-induced normal skin fibroblasts. European Food Research and Technology, 231, 163-169.
Servettaz,A., Kavian,N., Nicco,C., Deveaux,V., Chereau,C., Wang,A., Zimmer,A., Lotersztajn,S., Weill,B. and
Batteux,F. (2010) Targeting the Cannabinoid Pathway Limits the Development of Fibrosis and Autoimmunity
in a Mouse Model of Systemic Sclerosis. American Journal of Pathology, 177, 187 – 196.
Human Airway Fibroblasts
Sidhu,S.S., Yuan,S., Innes,A.L., Kerr,S., Woodruff,P.G., Hou,L., Muller,S.J. and Fahy,J.V. (2010) Roles of epithelial
cell-derived periostin in TGF- activation, collagen production, and collagen gel elasticity in asthma.
Proceedings of the National Academy of Sciences, 107, 14170 – 14175.
Murine Lung Tissue
Smith,M.R., Gangireddy,S.R., Narala,V.R., Hogaboam,C.M., Standiford,T.J., Christensen,P.J., Kondapi,A.K. and
Reddy,R.C. (2010) Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following
bleomycin-induced lung injury. American Journal of Physiology- Lung Cellular and Molecular
Physiology,298, L616 – L625.
Murine Lung Tissue
Song,J.S., Kang,C.M., Kang,H.H., Yoon,H.K., Kim,Y.K., Kim,K.H., Moon,H.S. and Park,S.H. (2010) Inhibitory effect
of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis.
Experimental & molecular medicine, 42, 465.
Human Left Diaphragmatic Tendon
Steigman,S.A., Oh,J.T., Almendinger,N., Javid,P., LaVan,D. and Fauza,D. (2010) Structural and biomechanical
characteristics of the diaphragmatic tendon in infancy and childhood: an initial analysis. Journal of
pediatric surgery, 45, 1455-1458.
Murine Lung Tissue
Stockmann,C., Kerdiles,Y., Nomaksteinsky,M., Weidemann,A., Takeda,N., Doedens,A., Torres-Collado,A.X., IruelaArispe,L., Nizet,V. and Johnson,R.S. (2010) Loss of myeloid cell-derived vascular endothelial growth factor
accelerates fibrosis. Proceedings of the National Academy of Sciences, 107, 4329.
Fibroblasts and Myofibroblasts
Suresh,M.V., Adapala,R.K., Hogaboam,C.M., Narala,V.R. and Reddy,R.C. (2010) Nitrated Fatty Acids Inhibit
Fibroblast-to-Myofibroblast Transdifferentiation Through PPAR-3 And SMAD 2/3 Signaling Pathways.
Normal Human Dermal Fibroblasts
Suwantong,O., Ruktanonchai,U. and Supaphol,P. (2010) In vitro biological evaluation of electrospun cellulose
acetate fiber mats containing asiaticoside or curcumin. Journal of Biomedical Materials Research Part A,
94, 1216-1225.
Surgical Sponges Impregnated with Plasmid
Sweetwyne,M.T., Pallero,M.A., Lu,A., Van Duyn Graham,L. and Murphy-Ullrich,J.E. (2010) The Calreticulin-Binding
Sequence of Thrombospondin 1 Regulates Collagen Expression and Organization During Tissue Remodeling.
American Journal of Pathology,177, 1710 - 1724.
Articular Cartilage
Szarko,M., Muldrew,K. and Bertram,J.E.A. (2010) Freeze-thaw effects on the dynamic mechanical properties of
articular cartilage. BMC Musculoskeletal Disorders, 11, 231.
Human Tenon’s Fibroblasts
Tappeiner,C., Meyenberg,A., Goldblum,D., Mojon,D., Zingg,J.M., Nesaretnam,K., Kilchenmann,M. and Frueh,B.E.
(2010) Antifibrotic effects of tocotrienols on human Tenon’s fibroblasts. Graefe's Archive for Clinical and
Experimental Ophthalmology, 248, 65-71.
Rat Skin Tissue
Tsuda,K., Nakatani,T., Sugama,J., Okuwa,M. and Sanada,H. (2010) Influence of the timing of switching a proteinfree to a protein-containing diet on the wound healing process in a rat all-layer skin defect. International
Wound Journal, 7, 135-146.
Normal Human dermal Fibroblasts (NHDFs)
Tsuji-Naito,K., Ishikura,S., Akagawa,M. and Saeki,H. (2010) α-Lipoic acid induces collagen biosynthesis involving
prolyl hydroxylase expression via activation of TGF-ß-Smad signaling in human dermal fibroblasts.
Connective Tissue Research, 51, 378-387.
Human Lung Fibroblasts (MRC-5)
Tung,J.N., Lang,Y.D., Wang,L.F. and Chen,C.M. (2010) Paraquat increases connective tissue growth factor and
collagen expression via angiotensin signaling pathway in human lung fibroblasts. Toxicology in Vitro, 24,
803-808.
Lamb Cervical Trachea
Turner,C.G.B., Klein,J.D., Ahmed,A., Zurakowski,D. and Fauza,D.O. (2010) A Large Animal Model of the Fetal
Tracheal Stenosis/Atresia Spectrum. Journal of Surgical Research, doi: 10.1016/j.jss.2010.02.037.
Murine Lung Tissue
Turpin,E.A., Antao-Menezes,A., Cesta,M.F., Mangum,J.B., Wallace,D.G., Bermudez,E. and Bonner,J.C. (2010)
Respiratory syncytial virus infection reduces lung inflammation and fibrosis in mice exposed to vanadium
pentoxide. Respiratory Research, 11, 20.
Murine Lung Tissue
Udalov,S., Dumitrascu,R., Pullamsetti,S.S., Al-tamari,H.M., Weissmann,N., Ghofrani,H.A., Guenther,A.,
Voswinckel,R., Seeger,W. and Grimminger,F. (2010) Effects of phosphodiesterase 4 inhibition on bleomycininduced pulmonary fibrosis in mice. BMC Pulmonary Medicine, 10, 26.
Bovine Primary Fibroblasts
Urciuolo,F., Imparato,G., Palmiero,C., Trilli,A. and Netti,P.A. (2010) Effect of process conditions on the growth of
3D dermal-equivalent tissue obtained by micro tissue precursor assembly. Tissue Engineering Part C,
doi:10.1089/ten.TEC.2010.0355.
Rat Glomeruli and Cultured Mesangial Cells
Urushihara,M., Takamatsu,M., Shimizu,M., Kondo,S., Kinoshita,Y., Suga,K., Kitamura,A., Matsuura,S., Yoshizumi,M.
and Tamaki,T. (2010) ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in
rat progressive glomerulonephritis. American Journal of Physiology- Renal Physiology, 298, F167 – F176.
Murine Lung Tissue, Murine Lung Primary Fibroblasts, Human Fetal Lung Fibroblasts HFL-1 Cell Line
van den Brule,S., Wallemme,L., Uwambayinema,F., Huaux,F. and Lison,D. (2010) The D prostanoid (DP) receptor
agonist BW245C ((4S)-(3-[(3R, S)-3-cyclohexyl-3-hydroxypropyl]-2, 5-dioxo)-4-imidazolidineheptanoic acid)
inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. Journal of Pharmacology and
Experimental Therapeutics, doi:10.1124/jpet.110.169250.
Mouse Embryonic Fibroblasts
Van Duyn Graham,L., Sweetwyne,M.T., Pallero,M.A. and Murphy-Ullrich,J.E. (2010) Intracellular calreticulin
regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular
matrix. Journal of Biological Chemistry, 285, 7067 - 7078.
Murine Lung Tissue
Vannella,K.M., Luckhardt,T.R., Wilke,C.A., van Dyk,L.F., Toews,G.B. and Moore,B.B. (2010) Latent Herpesvirus
Infection Augments Experimental Pulmonary Fibrosis. American Journal of Respiratory and Critical Care
Medicine, 181, 465.
Porcine Fibroblasts
Vavken,P., Joshi,S.M. and Murray,M.M. (2010) Fibrin concentration affects ACL fibroblast proliferation and collagen
synthesis. The Knee,18, 42 - 46.
Murine Skin Fibroblasts
Wang,J.C., Lai,S., Guo,X., Zhang,X., de Crombrugghe,B., Arnett,F. and Zhou,X. (2010) Attenuation of fibrosis in
vitro and in vivo with Sparc siRNA. Arthritis Research & Therapy, 12, R60.
Wang,L., Castranova,V., Mishra,A., Chen,B., Mercer,R.R., Schwegler-Berry,D. and Rojanasakul,Y. (2010) Dispersion
of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity
studies. Particle and Fibre Toxicology, 7, 31.
Murine Lung Tissue
Wang,Q., Li,H., Yao,Y., Xia,D. and Zhou,J. (2010) The Overexpression of Heparin-Binding Epidermal Growth Factor
Is Responsible for Th17-Induced Airway Remodeling in an Experimental Asthma Model. The Journal of
Immunology, 185, 834 -841.
Porcine Aortic Heart Valve Leaflets
Warnock,J.N., Gamez,C.A.P., Metzler,S.A., Chen,J., Elder,S.H. and Liao,J. (2010) Vasoactive Agents Alter the
Biomechanical Properties of Aortic Heart Valve Leaflets in a Time-Dependent Manner. Journal of Heart
Valve Disease, 19, 86-96.
Human Primary Osteoblast Cells
Whiteside,P., Matykina,E., Gough,J.E., Skeldon,P. and Thompson,G.E. (2010) In vitro evaluation of cell
proliferation and collagen synthesis on titanium following plasma electrolytic oxidation. Journal of
Biomedical Materials Research Part A, 94, 38-46.
Wilson,M.S., Madala,S.K., Ramalingam,T.R., Gochuico,B.R., Rosas,I.O., Cheever,A.W. and Wynn,T.A. (2010)
Bleomycin and IL-1β-mediated pulmonary fibrosis is IL-17A dependent. Journal of Experimental Medicine,
207, 535 – 552.
Rabbit Bone Marrow Mesenchymal Stem Cells
Xie,J., Han,Z., Naito,M., Maeyama,A., Kim,S.H., Kim,Y.H. and Matsuda,T. (2010) Articular cartilage tissue
engineering based on a mechano active scaffold made of poly (L lactide co caprolactone): In vivo
performance in adult rabbits. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 94,
80-88.
Murine Monocyte/Macrophage Cell Line (RAW264.7)
Yahyouche,A., Zhidao,X. and Czernuszka,J. (2011) Macrophage-Mediated Degradation of Crosslinked Collagen
Scaffolds. Acta Biomaterialia, 7, 278 - 286.
Kidney Epithelial Cells
Yang,L., Besschetnova,T.Y., Brooks,C.R., Shah,J.V. and Bonventre,J.V. (2010) Epithelial cell cycle arrest in G2/M
mediates kidney fibrosis after injury. Nature Medicine, 16, 535-543.
Primary Fibroblasts and Myofibroblasts
Zanotti,S., Gibertini,S. and Mora,M. (2010) Altered production of extra-cellular matrix components by musclederived Duchenne muscular dystrophy fibroblasts before and after TGF- ß1 treatment. Cell and Tissue
Research, 339, 397-410.
Murine Tendon Stem Cells (TSCs) and Tenocytes
Zhang,J., Pan,T., Liu,Y. and Wang,J.H. (2010) Mouse treadmill running enhances tendons by expanding the pool of
tendon stem cells (TSCs) and TSC related cellular production of collagen. Journal of Orthopaedic Research,
28, 1178-1183.
Murine Tendon Stem Cells
Zhang,J. and Wang,J.H.C. (2010) Platelet-Rich Plasma Releasate Promotes Differentiation of Tendon Stem Cells Into
Active Tenocytes. The American Journal of Sports Medicine, doi: 10.1177/0363546510376750.
Murine Lung Samples
Zhang,T., Srivastava,K., Wen,M.C., Yang,N., Cao,J., Busse,P., Birmingham,N., Goldfarb,J. and Li,X.M. (2010)
Pharmacology and immunological actions of a herbal medicine ASHMITM on allergic asthma. Phytotherapy
Research, 24, 1047-1055.
Human Scleral Fibroblasts
Zhou,X., Huang,Q., An,J., Lu,R., Qin,X., Jiang,L., Li,Y., Wang,J., Chen,J. and Qu,J. (2010) Genetic Deletion of the
Adenosine A2A Receptor Confers Postnatal Development of Relative Myopia in Mice. Investigative
Ophthalmology & Visual Science, 51, 4362 – 4370.
Murine Embryo Fibroblasts
Zito,E., Melo,E.P., Yang,Y., Wahlander,A., Neubert,T.A. and Ron,D. (2010) Oxidative Protein Folding by an
Endoplasmic Reticulum-Localized Peroxiredoxin. Molecular Cell, 40, 787-797.
2009
Allograft Collagen
Abreu,E.L., Palmer,M.P. and Murray,M.M. (2009) Storage conditions do not have detrimental effect on allograft
collagen or scaffold performance. Cell and Tissue Banking, 10, 333-340.
Murine Colon
Alexandra,M., Arthur,W., Van,P. and Derek,M. (2009) Infection with Hymenolepis diminuta Is More Effective than
Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice. Journal of Biomedicine and
Biotechnology, doi: 10.1155/2010/384523.
Fibroblast Cells
Aramwit,P., Kanokpanont,S., De-Eknamkul,W., Kamei,K. and Srichana,T. (2009) The Effect of Sericin with Variable
Amino-Acid Content from Different Silk Strains on the Production of Collagen and Nitric Oxide. Journal of
Biomaterials Science, Polymer Edition, 20, 1295-1306.
Fibroblast Populated Fibrin Gels
Balestrini,J.L. and Billiar,K.L. (2009) Magnitude and Duration of Stretch Modulate Fibroblast Remodeling. Journal of
Biomechanical Engineering, 131, 051005.
Osteoblasts
Ball,M.D., O’Connor,D. and Pandit,A. (2009) Use of tissue transglutaminase and fibronectin to influence osteoblast
responses to tricalcium phosphate scaffolds. Journal of Materials Science: Materials in Medicine, 20, 113122.
Murine Lung Tissue
Banerjee,E.R., Jiang,Y., Henderson,W.R., Latchman,Y. and Papayannopoulou,T. (2009) Absence of α4 but not ß2
integrins restrains development of chronic allergic asthma using mouse genetic models. Experimental
Hematology, 37, 715-727.
Murine Renal Tissue and a Proximal Tubule Epithelial Cell Line (HK-2 Cells)
Bani-Hani,A.H., Leslie,J.A., Asanuma,H., Dinarello,C.A., Campbell,M.T., Meldrum,D.R., Zhang,H., Hile,K. and
Meldrum,K.K. (2009) IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition
and renal fibrosis. Kidney International, 76, 500-511.
Mesenchymal Stem Cells on Chitosan Scaffold
Breyner, N.M., Hell, R.C.R., Carvalho, L.R.P., Machado, C.B., Peixoto Filho, I.N., Valério, P., Pereira,
M.M. and Goes, A.M. (2009) Effect of a Three-Dimensional Chitosan Porous Scaffold on the
Differentiation of Mesenchymal Stem Cells into Chondrocytes. Cells Tissues Organs, doi:
10.1159/000231472.
NIH 3T3 Fibroblasts
Chen,M., Michaud,H. and Bhowmick,S. (2009) Controlled Vacuum Seeding as a Means of Generating Uniform Cellular
Distribution in Electrospun Polycaprolactone (PCL) Scaffolds. Journal of Biomechanical Engineering, 131,
074521.
Rat Dorsal Tissue
Chung,P.S., Shin,J.I., Chang,S.Y. and Ahn,J.C. (2009) Histological Change and Collagen Formation on Laser
Wounded Rat using 808 Diode Laser and CO2 Laser. Science for the Life of Issue 1, 15, 81-86.
Murine Lung Tissue
Couillin,I., Vasseur,V., Charron,S., Gasse,P., Tavernier,M., Guillet,J., Lagente,V., Fick,L., Jacobs,M. and
Coelho,F.R. (2009) IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and
Emphysema. The Journal of Immunology, 183, 8195.
Human Mucosal Myofibroblasts
Di Sabatino,A., Jackson,C.L., Pickard,K.M., Buckley,M., Rovedatti,L., Leakey,N.A.B., Picariello,L., Cazzola,P.,
Monteleone,G. and Tonelli,F. (2009) Transforming growth factor ß signalling and matrix metalloproteinases
in the mucosa overlying Crohn's disease strictures. British Medical Journal, 58, 777-789.
Murine Lung Tissue
Du,G., Jin,L., Han,X., Song,Z., Zhang,H. and Liang,W. (2009) Naringenin: A Potential Immunomodulator for
Inhibiting Lung Fibrosis and Metastasis. Cancer Research, 69, 3205.
Porcine Bone Marrow-Derived Mesenchymal Cells (bMSCs)
Elder,S.H., Cooley Jr,A.J., Borazjani,A., Sowell,B.L., To,H. and Tran,S.C. (2009) Production of Hyaline-like
Cartilage by Bone Marrow Mesenchymal Stem Cells in a Self-Assembly Model. Tissue Engineering Part A, 15,
3025 – 3036.
Murine Lung Tissue
Failla,M., Genovese,T., Mazzon,E., Fruciano,M., Fagone,E., Gili,E., Barera,A., La Rosa,C., Conte,E. and Crimi,N.
(2009) 16, 16-Dimethyl Prostaglandin E2 Efficacy on Prevention and Protection from Bleomycin-Induced
Lung Injury and Fibrosis. American Journal of Respiratory Cell and Molecular Biology, 41, 50 – 58.
Skeletal Muscle Construct from C2C12 Myoblast Cell Line
Fujita,H., Shimizu,K. and Nagamori,E. (2009) Novel method for fabrication of skeletal muscle construct from the
C2C12 myoblast cell line using serum-free medium AIM-V. Biotechnology and Bioengineering, 103, 10341041.
Murine Lung Tissue
Glass,W.G., Argentieri,R.L., Bracht,M., Farrell,F.X., Das,A.M., Del Vecchio,A.M., Hogaboam,C.M. and Murray,L.A.
(2009) Generation of bleomycin-induced lung fibrosis is independent of IL-16. Cytokine, 46, 17–23.
Atherosclerotic Carotid Plaques
Gonçalves,I., Stollenwerk,M.M., Lindholm,M.W., Dias,N., Pedro,L.M., Fernandes,J.F., Moses,J., Fredrikson,G.N.,
Nilsson,J. and Ares,M.P.S. (2009) Activator protein-1 in carotid plaques is related to cerebrovascular
symptoms and cholesteryl ester content. Cardiovascular Pathology, doi: 10.1016/j.carpath.2009.09.003.
Human Bone Marrow Stromal Cells
Green,D.W., Bolland,B.J.R.F., Kanczler,J.M., Lanham,S.A., Walsh,D., Mann,S. and Oreffo,R.O.C. (2009)
Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere
biocomposites. Biomaterials, 30, 1918-1927.
Murine Colon Tissue
Guan,Q., Ma,Y., Hillman,C.L., Ma,A., Zhou,G., Qing,G. and Peng,Z. (2009) Development of recombinant vaccines
against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal
inflammation in murine colitis. Vaccine, 27, 7096 – 7104.
Articular Cartilages from Human Knee Joint
Han,D.W., Bae,J.Y. and Hyon,S.H. (2009) Biochemical and Histological Evaluations of Articular Cartilages Preserved
in Cold Storage Solution Containing Green Tea Catechin, EGCG. Tissue Engineering and Regenerative
Medicine, 6, 380-387.
Murine Asthma Model
Hansen,G. (2009) Different role of CD30 in the development of acute and chronic airway inflammation in a murine
asthma model. Eur.J.Immunol, 39, 1736-1742.
Bladder Smooth Muscle Cells
Heise,R.L., Ivanova,J., Parekh,A. and Sacks,M.S. (2009) Generating Elastin-Rich Small Intestinal Submucosa-Based
Smooth Muscle Constructs Utilizing Exogenous Growth Factors and Cyclic Mechanical Stimulation. Tissue
Engineering Part A, 15, 3951-3960.
Rat Renal Tissue
He,L., Qi,Y., Rong,X., Jiang,J., Yang,Q., Yamahara,J., Murray,M. and Li,Y. (2009) The Ayurvedic medicine Salacia
oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidencebased Complementary and Alternative Medicine, doi: 10.1093/ecam/nep095.
Murine Lung Mesenchymal Cells and Myofibroblasts
Hecker,L., Vittal,R., Jones,T., Jagirdar,R., Luckhardt,T.R., Horowitz,J.C., Pennathur,S., Martinez,F.J. and
Thannickal,V.J. (2009) NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung
injury. Nature Medicine, 15, 1077-1081.
Hemmatazad,H., Rodrigues,H.M., Maurer,B., Brentano,F., Pileckyte,M., Distler,J.H.W., Gay,R.E., Michel,B.A.,
Gay,S. and Huber,L.C. (2009) Histone deacetylase 7, a potential target for the antifibrotic treatment of
systemic sclerosis. Arthritis & Rheumatism, 60, 1519-1529.
Rabbit Subcutaneous Implant Model
Henry,J.A., Burugapalli,K., Neuenschwander,P. and Pandit,A. (2009) Structural variants of biodegradable
polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture. Acta
Biomaterialia, 5, 29-42.
Hermida,N., Lopez,B., Gonzalez,A., Dotor,J., Lasarte,J.J., Sarobe,P., Borras-Cuesta,F. and Diez,J. (2009) A
synthetic peptide from transforming growth factor-β 1 type III receptor prevents myocardial fibrosis in
spontaneously hypertensive rats. Cardiovascular Research, 81, 601.
Murine Embryonic Fibroblasts and Primary Hepatocytes
Hosui,A., Kimura,A., Yamaji,D., Zhu,B., Na,R. and Hennighausen,L. (2009) Loss of STAT5 causes liver fibrosis and
cancer development through increased TGF-ß and STAT3 activation. Journal of Experimental Medicine,
206, 819 - 831.
Human Osteoarthritis Cartilage explants and a Rabbit Model of Osteoarthritis
Huh,J.E., Baek,Y.H., Ryu,S.R., Lee,J.D., Choi,D.Y. and Park,D.S. (2009) Efficacy and mechanism of action of KHBJ9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit
model of collagenase-induced osteoarthritis. International Immunopharmacology, 9, 230-240.
Mouse Osteoclasts
Idris,A.I., Greig,I.R., Bassonga-Landao,E., Ralston,S.H. and van't Hof,R.J. (2009) Identification of Novel Biphenyl
Carboxylic Acid Derivatives as Novel Antiresorptive Agents that Do Not Impair Parathyroid Hormone-Induced
Bone Formation. Endocrinology, 150, 5-13.
Human Term Fetal Membranes
Jabareen,M., Mallik,A.S., Bilic,G., Zisch,A.H. and Mazza,E. (2009) Relation between mechanical properties and
microstructure of human fetal membranes: An attempt towards a quantitative analysis. European Journal
of Obstetrics and Gynecology, 144, 134-141.
Murine Lung Tissue
Kakizaki,T., Kohno,M., Watanabe,M., Tajima,A., Izumi,Y., Miyasho,T., Tasaka,S., Fukunaga,K., Maruyama,I. and
Ishizaka,A. (2009) Exacerbation of Bleomycin-Induced Injury and Fibrosis by Pneumonectomy in the Residual
Lung of Mice. Journal of Surgical Research, 154, 336-344.
Murine Lung Tissue
Kanda,A., Driss,V., Hornez,N., Abdallah,M., Roumier,T., Abboud,G., Legrand,F., Staumont-SalléD., Quéant,S. and
Bertout,J. (2009) Eosinophil-derived IFN- induces airway hyperresponsiveness and lung inflammation in the
absence of lymphocytes. The Journal of Allergy and Clinical Immunology, 124, 573-582.
Rat Renal Tissue and Cultured Mesangial Cells
Kang,Y.S., Ko,G.J., Lee,M.H., Song,H.K., Han,S.Y., Han,K.H., Kim,H.K., Han,J.Y. and Cha,D.R. (2009) Effect of
eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats.
Nephrology Dialysis Transplantation, 24, 73-84.
Kim,H.J., Song,S.B., Lee,J.Y., Cho,B.K., Cho,D.H. and Park,H.J. (2009) Interleukin-18 Downregulates Collagen
Production in Human Dermal Fibroblasts via ERK pathway. The Journal of Immunology, 182, 98-14.
Rat Ear Fibroblast Cells
Kim, J.-H. and Choi, J.-Y. (2009) Study on thermosensitivity of chitosan scaffold and on its effects on fibroblast
proliferation in cell therapy for soft tissue augmentation. J. Kor. Oral Maxillofac. Surg., 35, 146-152.
Rat Common Bile Duct Fibroblasts
Kim,T.H., Moon,J.H., Savard,C.E., Kuver,R. and Lee,S.P. (2009) Effects of lipopolysaccharide on platelet-derived
growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and
cholangiocytes. Journal of Gastroenterology and Hepatology, 24, 1218-1225.
Kim,Y.H. and Choi,E.M. (2009) Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric
oxide in MC3T3-E1 cells by pomegranate ethanol extract. Phytotherapy Research, 23, 737-739.
Immobilised Matrix Vesicle Model
Kinugawa,M., Fukuzawa,S. and Tachibana,K. (2009) Skeletal protein protection: the mode of action of an antiosteoporotic marine alkaloid, norzoanthamine. Journal of Bone and Mineral Metabolism, 27, 303-314.
Mouse and Human Lung Fibroblasts
Königshoff,M., Kramer,M., Balsara,N., Wilhelm,J., Amarie,O.V., Jahn,A., Rose,F., Fink,L., Seeger,W. and
Schaefer,L. (2009) WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is
upregulated in humans with idiopathic pulmonary fibrosis. The Journal of Clinical Investigation, 119, 772787.
Murine Bone Marrow Mesenchymal Stem Cells
Kumamoto,M., Nishiwaki,T., Matsuo,N., Kimura,H. and Matsushima,K. (2009) Minimally-cultured Bone Marrow
mesenchymal stem cells ameliorate fibrotic lung injury. European Respiratory Journal, doi:10.1183/
09031936-00128508.
Mouse Breast Cell Line
Lee,C.G., Hartl,D., Lee,G.R., Koller,B., Matsuura,H., Da Silva,C.A., Sohn,M.H., Cohn,L., Homer,R.J. and
Kozhich,A.A. (2009) Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13induced tissue responses and apoptosis. Journal of Experimental Medicine, 206, 1149-1166.
Chondrocytes
Lee,N.K., Oh,H.J., Hong,C.M., Suh,H. and Hong,S.H. (2009) Comparison of the synthetic biodegradable polymers,
polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage. Biotechnology
and Bioprocess Engineering, 14, 180-186.
Murine Lung Tissue
Lee,J., Reddy,R., Barsky,L., Scholes,J., Chen,H., Shi,W. and Driscoll,B. (2009) Lung alveolar integrity is
compromised by telomere shortening in telomerase-null mice. American Journal of Physiology- Lung
Cellular and Molecular Physiology, 296, L57.
Lefler,A. and Ghanem,A. (2009) Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal
Fibroblast Cells. Journal of Biomaterials Science, Polymer Edition, 20, 1335-1351.
Connective Tissue and Fibroblasts
Lin,Y.K. and Kuan,C.Y. (2009) Development of 4-hydroxyproline analysis kit and its application to collagen
quantification. Food Chemistry, doi: 10.1016/j.foodchem.2009.08.009.
Lin,Y.L., Lin,C.Y., Chi,C.W. and Huang,Y.T. (2009) Study on antifibrotic effects of curcumin in rat hepatic stellate
cells. Phytotherapy Research, 23, 927-932.
Rat Hepatic Stellate Cell Line (HSC-T6)
Lin,Y.L., Wu,C.F. and Huang,Y.T. (2009) Effects of rhubarb on migration of rat hepatic stellate cells. Journal of
Gastroenterology and Hepatology, 24, 453-461.
Human Myocardium
Lopez,B., Querejeta,R., Gonzalez,A., Beaumont,J., Larman,M. and Diez,J. (2009) Impact of Treatment on
Myocardial Lysyl Oxidase Expression and Collagen Cross-Linking in Patients With Heart Failure.
Hypertension, 53, 236-242.
Bone Marrow Cultures and Osteoblastic MC3T3-E1 Cells
Lozano,D., de Castro,L.F., Dapía,S., Andrade-Zapata,I., Manzarbeitia,F., Ayvarez-Arroyo,M., Gómez-Barrena,E. and
Esbrit,P. (2009) Role of Parathyroid Hormone-Related Protein in the Decreased Osteoblast Function in
Diabetes-Related Osteopenia. Endocrinology, 150, 2027-2035.
Murine Lung Tissue
Manicone,A.M., Huizar,I. and McGuire,J.K. (2009) Matrilysin (Matrix Metalloproteinase-7) Regulates AntiInflammatory and Antifibrotic Pulmonary Dendritic Cells That Express CD103 αE ß7-Integrin). American
Journal of Pathology, 175, 2319 – 2331.
Murine Lung Tissue
Markart,P., Luboeinski,T., Korfei,M., Schmidt,R., Wygrecka,M., Mahavadi,P., Mayer,K., Wilhelm,J., Seeger,W. and
Guenther,A. (2009) Alveolar Oxidative Stress is Associated with Elevated Levels of Nonenzymatic LowMolecular-Weight Antioxidants in Patients with Different Forms of Chronic Fibrosing Interstitial Lung
Diseases. Antioxidants & Redox Signaling, 11, 227-240.
Human Fibrocytes
Mehrad,B., Burdick,M.D. and Strieter,R.M. (2009) Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary
fibrosis. International Journal of Biochemistry and Cell Biology, 41, 1708-1718.
Human Retinal Pigment (ARPE-19) Cell Line
Morales,S.A., Mareninov,S., Wadehra,M., Zhang,L., Goodglick,L., Braun,J. and Gordon,L.K. (2009) FAK Activation
and the Role of Epithelial Membrane Protein 2 (EMP2) in Collagen Gel Contraction. Investigative
Ophthalmology & Visual Science, 50, 462-469.
EpiDerm FT Engineered Skin, Murine Epidermal Cells (JB6 P+) and Immune-Competent Hairless SKH-1
Mice
Murray,A.R., Kisin,E., Leonard,S.S., Young,S.H., Kommineni,C., Kagan,V.E., Castranova,V. and Shvedova,A.A.
(2009) Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes.
Toxicology, 257, 161-171.
Murine Peritoneal Fibroblasts
Nakav,S., Kachko,L., Vorobiov,M., Rogachev,B., Chaimovitz,C., Zlotnik,M. and Douvdevani,A. (2009) Blocking
adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models. Nephrology
Dialysis Transplantation, doi:10.1093/ndt/gfp041.
Bovine Chondrocytes Seeded in Non-Adherent Agarose Molds
Natoli,R.M., Revell,C.M. and Athanasiou,K.A. (2009) Chondroitinase ABC Treatment Results in Increased Tensile
Properties of Self-Assembled Tissue Engineered Articular Cartilage. Tissue Engineering.Part A, 15, 3119 –
3128.
Murine Lung Tissue
Nicola,T., Hagood,J.S., James,M.L., MacEwen,M.W., Williams,T.A., Hewitt,M.M., Schwiebert,L., Bulger,A.,
Oparil,S. and Chen,Y.F. (2009) Loss of Thy-1 inhibits alveolar development in the newborn mouse lung.
American Journal of Physiology- Lung Cellular and Molecular Physiology, 296, L738-L750.
Murine Lung Tissue
Niese,K.A., Collier,A.R., Hajek,A.R., Cederbaum,S.D., O'Brien,W.E., Wills-Karp,M., Rothenberg,M.E. and
Zimmermann,N. (2009) Bone marrow cell derived arginase I is the major source of allergen-induced lung
arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in
mice. BMC Immunology, 10, 33.
Murine Lung Fibroblasts
Oga,T., Matsuoka,T., Yao,C., Nonomura,K., Kitaoka,S., Sakata,D., Kita,Y., Tanizawa,K., Taguchi,Y. and Chin,K.
(2009) Prostaglandin F2 αreceptor signaling facilitates bleomycin-induced pulmonary fibrosis independently
of transforming growth factor-ß. Nature medicine, 15, 1426-1430.
Okada,M., Suzuki,K., Matsumoto,M., Takada,K., Nakanishi,T., Horikoshi,H., Higuchi,T., Hosono,Y., Nakayama,M.
and Ohsuzu,F. (2009) Effects of angiotensin on the expression of fibrosis-associated cytokines, growth
factors, and matrix proteins in human lung fibroblasts. Journal of Clinical Pharmacy & Therapeutics, 34,
289-299.
Rat Calvariae Osteoblasts
Orriss,I.R., Key,M.L., Colston,K.W. and Arnett,T.R. (2009) Inhibition of osteoblast function in vitro by
aminobisphosphonates. Journal of Cellular Biochemistry, 106, 109-118.
Swiss Mouse Intraplantar Region
Pareja-Santos,A., Saraiva,T.C., Costa,E.P., Santos,M.F., Zorn,T.T., Souza,V.M.O., Lopes-Ferreira,M. and Lima,C.
(2009) Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to
extracellular matrix degradation. International Journal of Experimental Pathology, 90, 34-43.
Park,H.J., Cho,D.H., Kim,H.J., Lee,J.Y., Cho,B.K., Bang,S.I., Song,S.Y., Yamasaki,K., Di Nardo,A. and Gallo,R.L.
(2009) Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37.
The Journal of investigative dermatology, 129, 843-850.
Rat Respiratory Tract
Pauluhn,J. (2009) Subchronic 13-week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects
are determined by Density of Agglomerate Structures, not fibrillar Structures. Toxicological Sciences, doi:
10.1093/toxsci/kfp247.
Tissue Engineered Valve Constructs Seeded With Mesenchymal Stem Cells
Ramaswamy,S., Gottlieb,D., Engelmayr,G.C., Aikawa,E., Schmidt,D.E., Gaitan-Leon,D.M., Sales,V.L., Mayer,J.E.
and Sacks,M.S. (2010) The role of organ level conditioning on the promotion of engineered heart valve
tissue development in-vitro using mesenchymal stem cells. Biomaterials, 31, 1114-1125.
Murine Lung Tissue
Ryman-Rasmussen,J.P., Tewksbury,E.W., Moss,O.R., Cesta,M.F., Wong,B.A. and Bonner,J.C. (2009) Inhaled
multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. American Journal of
Respiratory Cell and Molecular Biology, 40, 349-358.
Dermal Fibroblasts
Saesoo,S., Sramala,I., Soottitantawat,A., Charinpanitkul,T. and Ruktanonchai,U.R. (2009) Enhanced stability and in
vitro bioactivity of surfactant-loaded liposomes containing Asiatic Pennywort extract. Journal of
Microencapsulation, doi: 10.3109/02652040903447686.
Human Heart Valves
Schenke-Layland,K., Stock,U.A., Nsair,A., Xie,J., Angelis,E., Fonseca,C.G., Larbig,R., Mahajan,A., Shivkumar,K.,
Fishbein,M.C. and MacLellan, W.R. (2009) Cardiomyopathy is associated with structural remodelling of heart
valve extracellular matrix. European Heart Journal, 30, 2254-2265.
Schenke-Layland,K., Rofail,F., Heydarkhan,S., Gluck,J.M., Ingle,N.P., Angelis,E., Choi,C.H., MacLellan,W.R.,
Beygui,R.E. and Shemin,R.J. (2009) The use of three-dimensional nanostructures to instruct cells to produce
extracellular matrix for regenerative medicine strategies. Biomaterials, 30, 4665-4675.
Schnabel,L.V., Lynch,M.E., van der Meulen,M.C.H., Yeager,A.E., Kornatowski,M.A. and Nixon,A.J. (2009)
Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve
structural aspects of healing in equine flexor digitorum superficialis tendons. Journal of Orthopaedic
Research, 27, 1392-1398.
Anterior Cruciatge Ligament Cell and T-Lymophocytes on Composite Silk Scaffolds
Seo,Y.K., Yoon,H.H., Song,K.Y., Kwon,S.Y., Lee,H.S., Park,Y.S. and Park,J.K. (2009) Increase in cell migration and
angiogenesis in a composite silk scaffold for tissue-engineered ligaments. Journal of Orthopaedic Research,
27, 495-503.
Servettaz,A., Goulvestre,C., Kavian,N., Nicco,C., Guilpain,P., Chereau,C., Vuiblet,V., Guillevin,L., Mouthon,L. and
Weill,B. (2009) Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse. The
Journal of Immunology, 182, 5855-5864.
Murine Conjunctival Tissue
Shii,D., Nakagawa,S., Shinomiya,K., Yoshimi,M., Katsuta,O., Oda,T. and Nakamura,M. (2009) Cyclosporin A Eye
Drops Inhibit Fibrosis and Inflammatory Cell Infiltration in Murine Type I Allergic Conjunctivitis without
Affecting the Early-Phase Reaction. Current Eye Research, 34, 426-437.
Smooth Muscle Cells
Shin,J.W., Lee,Y.J., Heo,S.J., Park,S.A., Kim,S.H., Kim,Y.J., Kim,D.H. and Shin,J.W. (2009) Manufacturing of MultiLayered Nanofibrous Structures Composed of Polyurethane and Poly (ethylene oxide) as Potential Blood
Vessel Scaffolds. Journal of Biomaterials Science, Polymer Edition, 20, 5, 757-771.
Rat Myogenic Cells from Large Thigh Muscle
Stern,M.M., Myers,R.L., Hammam,N., Stern,K.A., Eberli,D., Kritchevsky,S.B., Soker,S. and Van Dyke,M. (2009) The
influence of extracellular matrix derived from skeletal muscle tissue on the proliferation and differentiation
of myogenic progenitor cells ex vivo. Biomaterials, 30, 2393-2399.
Mesenchymal Progenitor Cells (Fibrocytes)
Strieter,R.M., Keeley,E.C., Hughes,M.A., Burdick,M.D. and Mehrad,B. (2009) The role of circulating mesenchymal
progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. Journal of leukocyte biology, 86,
1111-1118.
Suh,K.S., Choi,E.M., Kwon,M., Chon,S., Oh,S., Woo,J.T., Kim,S.W., Kim,J.W. and Kim,Y.S. (2009) Kaempferol
Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in MC3T3-E1 Osteoblastic Cells. Biological &
Pharmaceutical Bulletin, 32, 746-749.
Rat Pancreatic Tissue
Suzuki,N., Masamune,A., Kikuta,K., Watanabe,T., Satoh,K. and Shimosegawa,T. (2009) Ellagic Acid Inhibits
Pancreatic Fibrosis in Male Wistar Bonn/Kobori Rats. Digestive Diseases and Sciences, 54, 802-810.
Murine Patellar Tendons
Szczodry,M., Zhang,J., Lim,C., Davitt,H.L., Yeager,T., Fu,F.H. and Wang,J.H.C. (2009) Treadmill running exercise
results in the presence of numerous myofibroblasts in mouse patellar tendons. Journal of Orthopaedic
Research, 27, 1373-1378.
Human Embryonic Stem Cells (hESCs)
Toh,W.S., Guo,X-M., Choo,A.B., Lu,K., Lee,E.H. and Cao,T. (2009) Differentiation and Enrichment of Expandable
Chondrogenic Cells from Human Embryonic Stem Cells in Vitro. Journal of Cellular and Molecular Medicine,
doi:10.1111/j.1582-4934.2009.00762.x.
Murine Hepatic Tissue
Tong,Z.Y., Chen,R., Alt,D.S., Kemper,S., Perbal,B. and Brigstock,D.R. (2009) Susceptibility to liver fibrosis in mice
expressing a connective tissue growth factor transgene in hepatocytes. Hepatology, 50, 939-947.
Rat Liver Tissue
Tsai,P.C., Fu,T.W., Chen,Y.M.A., Ko,T.L., Chen,T.H., Shih,Y.H., Hung,S.C. and Fu,Y.S. (2009) The therapeutic
potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver
fibrosis. Liver Transplantation, 15, 484-495.
Rat Glomeruli and Cultured Mesangial Cells
Urushihara,M., Takamatsu,M., Shimizu,M., Kondo,S., Kinoshita,Y., Suga,K., Kitamura,A., Matsuura,S., Yoshizumi,M.
and Tamaki,T. (2010) ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in
rat progressive glomerulonephritis. American Journal of Physiology- Renal Physiology, 298, F167 – F176.
Primary Human Cardiac Fibroblasts
Venkatachalam,K., Venkatesan,B., Valente,A.J., Melby,P.C., Nandish,S., Reusch,J.E.B., Clark,R.A. and
Chandrasekar,B. (2009) Wisp1, a pro-mitogenic, pro-survival factor, mediates TNF-alpha stimulated cardiac
fibroblast proliferation, but inhibits TNF-alpha-induced cardiomyocyte death. Journal of Biological
Chemistry, 284, 14414-14427.
Murine Diaphragm
Vetrone,S.A., Montecino-Rodriguez,E., Kudryashova,E., Kramerova,I., Hoffman,E.P., Liu,S.D., Miceli,M.C. and
Spencer,M.J. (2009) Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell
subsets and intramuscular TGF-ß. The Journal of Clinical Investigation, 119, 1583-1594.
Human Palmar Fascia Cells
Vi,L., Njarlangattil,A., Wu,Y., Gan,B.S. and O'Gorman,D.B. (2009) Type-1 collagen differentially alters beta-catenin
accumulation in primary Dupuytren's Disease cord and adjacent palmar fascia cells. BMC Musculoskeletal
Disorders, 10, 72.
Human Palmar Fascia Cells
Vi,L., Feng,L., Zhu,R.D., Wu,Y., Satish,L., Gan,B.S. and O'Gorman,D.B. (2009) Periostin differentially induces
proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells.
Experimental Cell Research, 315, 3574 – 3586.
Human Smooth Muscle Cells
Wang,C., Cen,L., Yin,S., Liu,Q., Liu,W., Cao,Y. and Cui,L. (2010) A small diameter elastic blood vessel wall
prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated
from adipose-derived stem cells. Biomaterials, 31, 621-630.
Murine Colonic Fibroblast Cells
Wang,H., Zhang,R., Wen,S., McCafferty,D.M., Beck,P.L. and MacNaughton,W.K. (2009) Nitric oxide increases Wntinduced secreted protein-1 (WISP-1/CCN4) expression and function in colitis. Journal of Molecular
Medicine, 87, 435-445.
Murine Calf Muscle
Watanuki,M., Kishimoto,K.N., Kotajima,S., Iwabuchi,S. and Kokubun,S. (2009) Effect of low-intensity pulsed
ultrasound on scaffold-free ectopic bone formation in skeletal muscle. Upsala Journal of Medical Sciences,
114, 242-248.
Rat Stellate Liver Cell Line (HSC-T6)
Weng,T.C., Shen,C.C., Chiu,Y.T., Lin,Y.L., Kuo,C.D. and Huang,Y.T. (2009) Inhibitory effects of armepavine against
hepatic fibrosis in rats. Journal of Biomedical Science, 16, 78.
Murine Lung Tissue
Wigenstam,E., Rocksén,D., Ekstrand-Hammarström,B. and Bucht,A. (2009) Treatment with dexamethasone or
liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury. Inhalation
Wu,M., Melichian,D.S., de la Garza,M., Gruner,K., Bhattacharyya,S., Barr,L., Nair,A., Shahrara,S., Sporn,P.H.S. and
Mustoe,T.A. (2009) Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis
and Wound Healing. American Journal of Pathology, 175, 1041.
Murine Model of Scleroderma
Wu,M., Melichian,D.S., Chang,E., Warner-Blankenship,M., Ghosh,A.K. and Varga,J. (2009) Rosiglitazone Abrogates
Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated
Receptor-γ. American Journal of Pathology, 174, 519.
Rat Liver Tissue
Yasoshima,M., Sato,Y., Furubo,S., Kizawa,K., Sanzen,T., Ozaki,S., Harada,K. and Nakanuma,Y. (2009) Matrix
proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and
Caroli's disease No conflicts of interest were declared. The Journal of Pathology, 217, 442-451.
Porcine Hind Leg Tibial Osteochondral Explants
Yeow,C.H., Lau,S.T., Lee,P.V.S. and Goh,J.C.H. (2009) Damage and degenerative changes in menisci-covered and
exposed tibial osteochondral regions after simulated landing impact compression-a porcine study. Journal
of Orthopaedic Research, 27, 1100-1108.
Equine Tendon Tissue
Young,N.J., Becker,D.L., Fleck,R.A., Goodship,A.E. and Patterson-Kane,J.C. (2009) Maturational alterations in gap
junction expression and associated collagen synthesis in response to tendon function. Matrix Biology, 28,
311-323.
Mouse Embryonic Fibroblast Cell Line (NIH 3T3)
Zhang,W., Rong,J., Wang,Q. and He,X. (2009) The encapsulation and intracellular delivery of trehalose using a
thermally responsive nanocapsule. Nanotechnology, 20, 275101.
Mouse Model of Atopic Dermatitis
Zheng,T., Oh,M., Oh,S., Wu,F., Myers,A. and Zhu,Z. (2009) IL-13 Regulation of Skin Remodeling in a Mouse Model of
Atopic Dermatitis. The Journal of Allergy and Clinical Immunology, 123, 35.
Murine Lung Tissue
Zhou,Y., Mohsenin,A., Morschl,E., Young,H.W.J., Molina,J.G., Ma,W., Sun,C.X., Martinez-Valdez,H. and
Blackburn,M.R. (2009) Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient
Mice Lacking the A2B Adenosine Receptor. The Journal of Immunology, 182, 8037-8046.
2008
Mouse Model of Dermal Fibrosis
Akhmetshina,A., Dees,C., Pileckyte,M., Maurer,B., Axmann,R., Jungel,A., Zwerina,J., Gay,S., Schett,G. and
Distler,O. (2008) Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the
treatment of dermal fibrosis. The FASEB Journal, 22, 2214-2222.
Scleroderma Fibroblasts
Akhmetshina,A., Dees,C., Pileckyte,M., Szucs,G., Spriewald,B.M., Zwerina,J., Distler,O., Schett,G. and Distler,J.H.
(2008) Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular
matrix in scleroderma fibroblasts. Arthritis Rheum, 58, 2553-2564.
Rabbit Bone Marrow Cells Seeded on Porcine Small Intestine Submucosa
Almarza,A.J., Yang,G., Woo,S.L.Y., Nguyen,T. and Abramowitch,S.D. (2008) Positive Changes in Bone MarrowDerived Cells in Response to Culture on an Aligned Bioscaffold. Tissue Engineering, 14, 1489-1495.
Antao-Menezes,A., Turpin,E.A., Bost,P.C., Ryman-Rasmussen,J.P. and Bonner,J.C. (2008) STAT-1 Signaling in
Human Lung Fibroblasts Is Induced by Vanadium Pentoxide through an IFN-beta Autocrine Loop. The
Journal of Immunology, 180, 4200-4207.
Cultured Human Intrahepatic (Myo) Fibroblasts (hIHFs)
Aoudjehane,L., Pissaia,A., Scatton,O., Podevin,P., Massault,P.P., Chouzenoux,S., Soubrane,O., Calmus,Y. and
Conti,F. (2008) Interleukin-4 induces the activation and collagen production of cultured human intrahepatic
fibroblasts via the STAT-6 pathway. Laboratory Investigation, 88, 973-985.
Bhogal, R.K. and Bona, C.A. (2008) Regulatory Effect of Extracellular Signal- Regulated Kinases (ERK) on Type I
Collagen Synthesis in Human Dermal Fibroblasts Stimulated by IL-4 and IL-13. International Reviews of
Immunology, 27, 472 – 496.
Porcine Valvular Interstitial Cells from Various Regions of the Mitral Valve
Blevins,T.L., Peterson,S.B., Lee,E.L., Bailey,A.M., Frederick,J.D., Huynh,T.N., Gupta,V. and Grande-Allen,K. (2008)
Mitral Valvular Interstitial Cells Demonstrate Regional, Adhesional, and Synthetic Heterogeneity. Cells
Tissues Organs, 187, 113-122.
Human Lung Fibroblasts and Mouse Bleomycin Induced Lung Fibrosis
Borie,R., Fabre,A., Prost,F., Marchal-Somme,J., Lebtahi,R., Marchand-Adam,S., Aubier,M., Soler,P. and Crestani,B.
(2008) Activation of somatostatin receptors attenuates pulmonary fibrosis. Thorax, 63, 251-258.
An Alloxan Rabbit Ear Ulcer Model
Breen,A.M., Dockery,P., O'Brien,T. and Pandit,A.S. (2008) The use of therapeutic gene eNOS delivered via a fibrin
scaffold enhances wound healing in a compromised wound model. Biomaterials, 29, 3143-3151.
Polycarbonate Track-Etched Membranes
Bueno,E.M. and Ruberti,J.W. (2008) Optimizing collagen transport through track-etched nanopores. Journal of
Membrane Science, 321, 250-263.
Caraci,F., Gili,E., Calafiore,M., Failla,M., La Rosa,C., Crimi,N., Sortino,M.A., Nicoletti,F., Copani,A. and
Vancheri,C. (2008) TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of
human lung fibroblasts into myofibroblasts. Pharmacological Research, 57, 274-282.
Fetal Rat Lung Tissue
Chen,C.M., Chou,H.C., Wang,L.F. and Lang,Y.D. (2008) Experimental Oligohydramnios Decreases Collagen in
Hypoplastic Fetal Rat Lungs. Experimental Biology and Medicine, 233, 1334-1340.
Rabbit Digitorum Extensor Tendon
Chen,C.H., Liu,H.W., Tsai,C.L., Yu,C.M. and Lin,I. (2008) Photoencapsulation of Bone Morphogenetic Protein-2 and
Periosteal Progenitor Cells Improve Tendon Graft Healing in a Bone Tunnel. The American Journal of Sports
Medicine, 36, 461-473.
Murine Osteoblastic MC3T3-E1 Cells
Choi,E.M. and Kim,Y.H. (2008) Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast
differentiation. Cell Biology and Toxicology, 24, 225-231.
Bone Marrow Derived Mesenchymal Stem Cells (MSCs)
Choi,K.M., Seo,Y.K., Yoon,H.H., Song,K.Y., Kwon,S.Y., Lee,H.S. and Park,J.K. (2008) Effect of ascorbic acid on
bone marrow-derived mesenchymal stem cell proliferation and differentiation. Journal of Bioscience and
Bioengineering, 105, 586-594.
Rabbit Autologous Cells from Vaginal Biopsy
De Philippo,R.E., Bishop,C.E., Freitas Filho,L., Yoo,J.J. and Atala,A. (2008) Tissue Engineering a Complete Vaginal
Replacement From a Small Biopsy of Autologous Tissue. Transplantation, 86, 208-214.
Human Fibroblasts from Systemic Sclerotic Patients
Distler,J.H.W., Akhmetshina,A., Schett,G. and Distler,O. (2008) Monocyte chemoattractant proteins in the
pathogenesis of systemic sclerosis. Rheumatology, 48, 98-103.
Atherosclerotic Lesions in Apo-E-Deficient Mice
Do,G.M., Kwon,E.Y., Kim,H.J., Jeon,S.M., Ha,T.Y., Park,T. and Choi,M.S. (2008) Long-term effects of resveratrol
supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient
mice. Biochemical and Biophysical Research Communications, 374, 55-59.
Rat Lung Tissue
Elgrabli,D., bella-Gallart,S., Robidel,F., Rogerieux,F., Boczkowski,J. and Lacroix,G. (2008) Induction of apoptosis
and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes.
Murine Lung Tissue
Fabre,A., Marchal-Somme,J., Marchand-Adam,S., Quesnel,C., Borie,R., Dehoux,M., Ruffie,C., Callebert,J.,
Launay,J.M. and Henin,D. (2008) Modulation of bleomycin induced lung fibrosis by serotonin receptor
antagonists in mice. European Respiratory Journal, doi:10.1183/09031936-00126907.
Murine Lung Tissue
Failla,M., Genovese,T., Mazzon,E., Fruciano,M., Fagone,E., Gili,E., Barera,A., La Rosa,C., Conte,E., Crimi,N.,
Cuzzocrea, S. and Vaneheri, C. (2008) 16, 16-Dimethyl Prostaglandin E2 Efficacy on Prevention and
Protection from Bleomycin-induced Lung Injury and Fibrosis. American Journal of Respiratory Cell and
Molecular Biology, doi:10.1165/rcmb.2007-04380C.
Fan,H., Liu,H., Toh,S.L. and Goh,J.C.H. (2008) Enhanced differentiation of mesenchymal stem cells co-cultured
with ligament fibroblasts on gelatin/silk fibroin hybrid scaffold. Biomaterials, 29, 1017-1027.
Mesenchymal Stem Cells and Silk Scaffold
Fan,H., Liu,H., Wong,E.J.W., Toh,S.L. and Goh,J.C.H. (2008) In vivo study of anterior cruciate ligament
regeneration using mesenchymal stem cells and silk scaffold. Biomaterials, 29, 3324-3337.
Murine Intestinal Myofibroblasts
Fichtner-Feigl,S., Young,C.A., Kitani,A., Geissler,E.K., Schlitt,H.J. and Strober,W. (2008) IL-13 Signaling via IL13Ra2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis.
Gastroenterology, 135, 2003-2013.e7.
Bone Marrow Samples
Freyman, T. (2008) Decellularized bone marrow extracellular matrix. US Patent 7326571.
Cartilage Tissue
Furukawa,K.S., Imura,K., Tateishi,T. and Ushida,T. (2008) Scaffold-free cartilage by rotational culture for tissue
engineering. Journal of Biotechnology, 133, 134-145.
Collagen Based Scaffolds
Garcia,Y., Wilkins,B., Collighan,R.J., Griffin,M. and Pandit,A. (2008) Towards development of a dermal rudiment
for enhanced wound healing response. Biomaterials, 29, 857-868.
Hepatic Stellate Cells
Gardi,C., Arezzini,B., Monaco,B., De Montis,M.G., Vecchio,D. and Comporti,M. (2008) F 2-isoprostane receptors on
hepatic stellate cells. Laboratory Investigation, 88, 124-131.
ECM Model of Fibroblast Monolayer and Endothelial Cell-Coated Beads
Ghajar,C.M., Chen,X., Harris,J.W., Suresh,V., Hughes,C.C.W., Jeon,N.L., Putnam,A.J. and George,S.C. (2008) The
Effect of Matrix Density on the Regulation of 3-D Capillary Morphogenesis. Biophysical Journal, 94, 19301941.
Human Carotid Plaques
Gonçalves, I., Ares, M.P.S., Moberg, A., Moses, J., To, F., Montan, J., Pedro, L.M., Dias, N., e Fernandes, J.F.,
Fredrikson, G.N., Nilsson, J., Jovinge, S. and Bengtsson, E. (2008) Elastin- and Collagen-Rich Human Carotid
Plaques Have Increased Levels of the Cysteine Protease Inhibitor Cystatin C. Journal of Vascular Research,
45, 395 – 401.
Murine Intestinal Tissue
Grassl,G.A., Valdez,Y., Bergstrom,K.S.B., Vallance,B.A. and Finlay,B.B. (2008) Chronic Enteric Salmonella Infection
in Mice Leads to Severe and Persistent Intestinal Fibrosis. Gastroenterology, 134,768-780.e2.
293 T-Rex Cell Line
Greenspan,D., Zhang,Y. and GE,G. (2008) Method and composition for treating a fibrotic disorder. WIPO Patent
Application WO/2008/024767.
Porcine Valvular Interstitial Cells from Distinct Regions of Mitral Valve
Gupta,V., Werdenberg,J.A., Mendez,J.S. and Jane Grande-Allen,K. (2008) Influence of strain on proteoglycan
synthesis by valvular interstitial cells in three-dimensional culture. Acta Biomaterialia, 4, 88-96.
Porcine Valvular Interstitial Cells from Valve Leaflet and Chordae
Gupta,V., Werdenberg,J.A., Lawrence,B.D., Mendez,J.S., Stephens,E.H. and Grande-Allen,K.J. (2008) Reversible
Secretion of Glycosaminoglycans and Proteoglycans by Cyclically Stretched Valvular Cells in 3D Culture.
Annals of Biomedical Engineering, 36, 1092-1103.
Demineralized Bone Matrix
Han,B., Yang,Z. and Nimni,M. (2008) Effects of gamma irradiation on osteoinduction associated with demineralized
bone matrix. Journal of Orthopaedic Research, 26, 75-82.
Murine Lung Tissue
Hardie,W.D., Davidson,C., Ikegami,M., Leikauf,G.D., Le Cras,T.D., Prestridge,A., Whitsett,J.A. and Korfhagen,T.R.
(2008) EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-α-induced pulmonary
fibrosis. American Journal of Physiology- Lung Cellular and Molecular Physiology, 294, L1217-L1225.
Rabbit Fibrocartilaginous Tissues
Hashem,G., Zhang,Q., Hayami,T., Chen,J., Wang,W. and Kapila,S. (2008) Relaxin and β-estradiol modulate targeted
matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis
Research and Therapy, 8, R98.
Murine Lung Tissue
Hashimoto,S., Amaya,F., Matsuyama,H., Ueno,H., Kikuchi,S., Tanaka,M., Watanabe,Y., Ebina,M., Ishizaka,A. and
Tsukita,S. (2008) Dysregulation of lung injury and repair in moesin-deficient mice treated with intratracheal
bleomycin. American Journal of Physiology- Lung Cellular and Molecular Physiology, 295, L566-L574.
Human Annulus Fibrosus (HAF) Cells
Helen,W. and Gough,J.E. (2008) Cell viability, proliferation and extracellular matrix production of human annulus
fibrosus cells cultured within PDLLA/Bioglass® composite foam scaffolds in vitro. Acta Biomaterialia, 4,
230-243.
Murine Lung Tissue
Hirata,H., Arima,M., Fukushima,Y., Ishii,Y., Tokuhisa,T. and Fukuda,T. (2008) Effects of Th2 pulmonary
inflammation in mice with bleomycin-induced pulmonary fibrosis. Respirology, 13, 788-798.
Murine Liver Tissue
Hisamori,S., Tabata,C., Kadokawa,Y., Okoshi,K., Tabata,R., Mori,A., Nagayama,S., Watanabe,G., Kubo,H. and
Sakai,Y. (2008) All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice
through modulating cytokine production. Liver International, 28, 1217-1225.
Rat Mesenchymal Stem Cells and Porcine Aortic Valve Leaflets.
Hong,H., Dong,G.N., Shi,W.J., Chen,S., Guo,C. and Hu,P. (2008) Fabrication of Biomatrix/Polymer Hybrid Scaffold
for Heart Valve Tissue Engineering in Vitro. ASAIO Journal, 54, 627-632.
Murine Dorsum
Hong,H.J., Jin,S.E., Park,J.S., Ahn,W.S. and Kim,C.K. (2008) Accelerated wound healing by smad3 antisense
oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex. Biomaterials, 29, 4831-4837.
Mouse Model of Scleroderma
Hoyles,R.K., Khan,K., Shiwen,X., Howat,S.L., Lindahl,G.E., Leoni,P., du Bois,R.M., Wells,A.U., Black,C.M. and
Abraham,D.J. (2008) Fibroblast-Specific Perturbation of Transforming Growth Factor Signaling Provides
Insight Into Potential Pathogenic Mechanisms of Scleroderma-Associated Lung Fibrosis. Arthritis &
Rheumatism, 58, 1175-1188.
Mouse Cardiac Fibroblasts
Hu,C., Dandapat,A., Sun,L., Khan,J.A., Liu,Y., Hermonat,P.L. and Mehta,J.L. (2008) Regulation of TGF β1-mediated
Collagen Formation by LOX-1: Studies Based on Forced Overexpression of TGF β1 in Wild-Type and LOX-1
Knock-Out Mouse Cardiac Fibroblasts. Journal of Biological Chemistry, 283, 10226-10231.
Human Cartilage Culture and a Rabbit Model of Osteoarthritis
Huh,J.E., Baek,Y.H., Ryu,S.R., Lee,J.D., Choi,D.Y. and Park,D.S. (2008) Efficacy and mechanism of action of KHBJ9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit
model of collagenase-induced osteoarthritis. International Immunopharmacology, 9, 230-240.
Osteoblasts In Vitro and Calvarial Osteoblasts In Vivo
Idris,A.I., Rojas,J., Greig,I.R., van’t Hof,R.J. and Ralston,S.H. (2008) Aminobisphosphonates Cause Osteoblast
Apoptosis and Inhibit Bone Nodule Formation In Vitro. Calcified Tissue International, 82, 191-201.
Inagaki,K., Koyanagi,T., Berry,N.C., Sun,L. and Mochly-Rosen,D. (2008) Pharmacological Inhibition of ε-Protein
Kinase C Attenuates Cardiac Fibrosis and Dysfunction in Hypertension-Induced Heart Failure. Hypertension,
51, 1565.
Human Periodontal Ligament Cell Line (HPL)
Inubushi,T., Tanaka,E., Rego,E.B., Kitagawa,M., Kawazoe,A., Ohta,A., Okada,H., Koolstra,J.H., Miyauchi,M. and
Takata,T. (2008) Effects of Ultrasound on the proliferation and differentiation of Cementoblast lineage
Cells. Journal of Periodontology, 79, 1-2.
Primary Hepatic Stellate Cells from Wild Type and Sept 4-/-Mice
Iwaisako,K., Hatano,E., Taura,K., Nakajima,A., Tada,M., Seo,S., Tamaki,N., Sato,F., Ikai,I. and Uemoto,S. (2008)
Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells. Journal of
Hepatology, 49, 768-778.
Murine Lung Tissue
Kakizaki,T., Kohno,M., Watanabe,M., Tajima,A., Izumi,Y., Miyasho,T., Tasaka,S., Fukunaga,K., Maruyama,I. and
Ishizaka,A. (2008) Exacerbation of Bleomycin-Induced Injury and Fibrosis by Pneumonectomy in the Residual
Lung of Mice. Journal of Surgical Research, doi:10.1016/j.jss.2008.06.021.
Kang,Y.S., Ko,G.J., Lee,M.H., Song,H.K., Han,S.Y., Han,K.H., Kim,H.K., Han,J.Y. and Cha,D.R. (2008) Effect of
eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats.
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn448.
Murine Skin
Kanno,Y., Kaneiwa,A., Minamida,M., Kanno,M., Tomogane,K., Takeuchi,K., Okada,K., Ueshima,S., Matsuo,O. and
Matsuno,H. (2008) The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis. Journal of
Investigative Dermatology, doi:10.1038/jid.2008.157.
Kim,J.Y., Park,S.H., Cho,K.S., Kim,H.J., Lee,C.K., Park,K.K., Choi,S.H. and Chung,W.Y. (2008) Mechanism of
Azithromycin Treatment on Gingival Overgrowth. Journal of Dental Research, 87, 1075.
Mouse Primary and NIH/3T3 Fibroblasts
Kitowska,K., Zakrzewicz,D., Königshoff,M., Chrobak,I., Grimminger,F., Seeger,W., Bulau,P. and Eickelberg,O.
(2008) Functional role and species-specific contribution of arginases in pulmonary fibrosis. American
Journal of Physiology- Lung Cellular and Molecular Physiology, 294, L34-L45.
Ko,G.J., Kang,Y.S., Han,S.Y., Lee,M.H., Song,H.K., Han,K.H., Kim,H.K., Han,J.Y. and Cha,D.R. (2008) Pioglitazone
attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.
Nephrology Dialysis Transplantation, 23, 2750-2760.
Lung Epithelial Cells
Königshoff,M., Balsara,N., Pfaff,E.M., Kramer,M., Chrobak,I., Seeger,W. and Eickelberg,O. (2008) Functional Wnt
Signaling Is Increased in Idiopathic Pulmonary Fibrosis. PLoS ONE, 3 (5)
e2142.doi:1371/journal.pone.0002142.
Rat Bone Marrow-Derived Mesenchymal Stromal Cells (BMSCs)
Kwon,D.S., Gao,X., Liu,Y.B., Dulchavsky,D.S., Danyluk,A.L., Bansal,M., Chopp,M., McIntosh,K., Arbab,A.S. and
Dulchavsky,S.A. (2008) Treatment with bone marrow-derived stromal cells accelerates wound healing in
diabetic rats. International Wound Journal, 5, 453-463.
Mouse Osteoblastic MC3T3-E1 Cell Line
Lee,K.H. and Choi,E.M. (2008) Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-d-ribose induced
dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. European Journal of Pharmacology, 591,
1-6.
Murine Lung Tissue
Lee,K.S., Park,S.J., Kim,S.R., Min,K.H., Lee,K.Y., Choe,Y.H., Hong,S.H., Lee,Y.R., Kim,J.S. and Hong,S.J. (2008)
Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signalling pathway. European Respiratory
Journal, 31, 523-531.
Murine Tissue
Lee,S.J., Van Dyke,M., Atala,A. and Yoo,J.J. (2008) Host Cell Mobilization for In Situ Tissue Regeneration.
Rejuvenation Research, 11, 747-756.
Murine Lung Tissue
Le Saux,O., Teeters,K., Miyasato,S., Choi,J., Nakamatsu,G., Richardson,J.A., Starcher,B., Davis,E.C., Tam,E.K. and
Jourdan-Le Saux,C. (2008) The role of caveolin-1 in pulmonary matrix remodeling and mechanical
properties. American Journal of Physiology- Lung Cellular and Molecular Physiology, 295, L1007-L1017.
Renal Tissue of Zucker Diabetic Fatty Rats
Li,Y., Qi,Y., Kim,M.S., Xu,K.Z., Huang,T.H., Rong,X., Murray,M. and Yamahara,J. (2008) Increased renal collagen
cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats. Diabetes Metab Res Rev.,
24, 498-506.
Cardiac Fibroblasts
Lijnen,P., Petrov,V., van Pelt,J. and Fagard,R. (2008) Inhibition of Superoxide Dismutase Induces Collagen
Production in Cardiac Fibroblasts. American Journal of Hypertension, 21, 1129-1136.
Human Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis and Human Fibroblasts
Lin,L., Zhou,Z., Zheng,L., Alber,S., Watkins,S., Ray,P., Kaminski,N., Zhang,Y. and Morse,D. (2008) Cross Talk
between Id1 and Its Interactive Protein Dril1 Mediate Fibroblast Responses to Transforming Growth Factor-β
in Pulmonary Fibrosis. American Journal of Pathology, 173, 337-346.
Rat Hepatic Stellate Cell Line (HSC-T6)
Lin,Y.L., Wu,C.F. and Huang,Y.T. (2008) Effects of rhubarb on migration of rat hepatic stellate cells. Journal of
Gastroenterology and Hepatology, doi:10.1111/j.1440-1746.2008.05573.x.
Osteoblasts
Liu,H., Yazici,H., Ergun,C., Webster,T.J. and Bermek,H. (2008) An in vitro evaluation of the Ca/P ratio for the
cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration. Acta
Biomaterialia, 4, 1472-1479.
Normal Human Bronchial Epithelial Cells
Malavia,N.K., Mih,J.D., Raub,C.B., Dinh,B.T., George,S.C., Tirumurugaan,K.G., Kang,B.N., Panettieri,R.A.,
Foster,D.N. and Walseth,T.F. (2008) IL-13 induces a bronchial epithelial phenotype that is profibrotic.
Respiratory Research, 9, 27.
Leiomyoma and Myometrial Cells
Malik,M., Webb,J. and Catherino,W.H. (2008) Retinoic acid treatment of human leiomyoma cells transformed the
cell phenotype to one strongly resembling myometrial cells. Clinical Endocrinology, 69, 462-470.
Rat Cardiomyocytes
Mancuso,P., Rahman,A., Hershey,S.D., Dandu,L., Nibbelink,K.A. and Simpson,R.U. (2008) 1, 25-Dihydroxyvitamin-D3
Treatment Reduces Cardiac Hypertrophy and Left Ventricular Diameter in Spontaneously Hypertensive Heart
Failure-prone (cp/+) Rats Independent of Changes in Serum Leptin. Journal of Cardiovascular
Murine Model of Plexiform Neurofibroma
McDaniel,A.S. (2008) The role of PAK1 in the cellular and molecular components of plexiform neurofibromas.
http://hdl.handle.net/1805/1696.
Human Lung Fibroblasts and Myofibroblasts
Milam,J.E., Keshamouni,V.G., Phan,S.H., Hu,B., Gangireddy,S.R., Hogaboam,C.M., Standiford,T.J., Thannickal,V.J.
and Reddy,R.C. (2008) PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and
bleomycin-induced pulmonary fibrosis. American Journal of Physiology- Lung Cellular and Molecular
Physiology, 294, L891-L901.
Human Retinal Pigment Epithelial (ARPE-19) Cell Line
Morales,S.A., Mareninov,S., Wadehra,M., Zhang,L., Goodglick,L., Braun,J. and Gordon,L.K. (2008) Epithelial
Membrane Protein 2 (EMP2) Controls Collagen Gel Contraction in ARPE-19 Cells by Modulating FAK
Activation. Investigative Ophthalmology & Visual Science, doi:10:1167/iovs.07-1598.
Murine Lung Tissue
Mozaffarian,A., Brewer,A.W., Trueblood,E.S., Luzina,I.G., Todd,N.W., Atamas,S.P. and Arnett,H.A. (2008)
Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis. The Journal of Immunology,
181, 7243.
Human IPF/UIP Fibroblasts
Murray,L.A., Argentieri,R.L., Farrell,F.X., Bracht,M., Sheng,H., Whitaker,B., Beck,H., Tsui,P., Cochlin,K. and
Evanoff,H.L. (2008) Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2.
International Journal of Biochemistry and Cell Biology, 40, 2174-2182.
Murray,L.A., Hackett,T.L., Warner,S.M., Shaheen,F., Argentieri,R.L., Dudas,P., Farrell,F.X. and Knight,D.A. (2008)
BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis. PLoS ONE, 3,e4039.
Bovine Articular Cartilage
Natoli,R.M., Scott,C.C. and Athanasiou,K.A. (2008) Temporal Effects of Impact on Articular Cartilage Cell Death,
Gene Expression, Matrix Biochemistry, and Biomechanics. Annals of Biomedical Engineering, 36, 780-792.
Murine Model of Liver Cirrhosis
Nishibe,Y., Kaneko,H., Suzuki,H., Abe,T., Matsuura,Y. and Takaku,H. (2008) Baculovirus-mediated interferon
alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model. Gene Therapy, 15,
990-997.
Horse Superficial Digital Flexor Tendon
Nixon,A.J., Dahlgren,L.A., Haupt,J.L., Yeager,A.E. and Ward,D.L. (2008) Effect of adipose-derived nucleated cell
fractions on tendon repair in horses with collagenase-induced tendinitis. American Journal of Veterinary
Research, 69, 928-937.
Ocarino,N.M., Boeloni,J.N., Goes,A.M., Silva,J.F., Marubayashi,U. and Serakides,R. (2008) Osteogenic
differentiation of mesenchymal stem cells from osteopenic rats subjected to physical activity with and
without nitric oxide synthase inhibition. Nitric Oxide, 19,320-325.
Murine Intestinal Tissue
Okoshi,K., Kubo,H., Nagayama,S., Tabata,C., Kadokawa,Y., Hisamori,S., Yonenaga,Y., Fujimoto,A., Mori,A. and
Onodera,H. (2008) All-trans-Retinoic Acid Attenuates Radiation-Induced Intestinal Fibrosis in Mice. Journal
of Surgical Research, 150, 53-59.
Normal Human Lung Fibroblast (NHLF) Cells
Pandey, A., Scarborough, R. M., and Venkatraman, M. S. (2008) Compositions and methods for inhibiting TGF-β. US
Patent 7314939.
Park,H.J., Cho,D.H., Kim,H.J., Lee,J.Y., Cho,B.K., Bang,S.I., Song,S.Y., Yamasaki,K., Di Nardo,A. and Gallo,R.L.
(2008) Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37.
Journal of Investigative Dermatology, doi:10.1038/jid.2008.320.
Rabbit Mesenchymal Cells
Park,K.H. and Na,K. (2008) Effect of growth factors on chondrogenic differentiation of rabbit mesenchymal cells
embedded in injectable hydrogels. Journal of Bioscience and Bioengineering, 106, 74-79.
Richardson,S.M., Hughes,N., Hunt,J.A., Freemont,A.J. and Hoyland,J.A. (2008) Human mesenchymal stem cell
differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials, 29, 85-93.
Normal Human Lung Fibroblast (NHLF) Cells
Scarborough, R. M., Pandey, A., and Mehrotra, M. (2008) Compositions and method for inhibiting TGF-β. US Patent
7361669.
Lacrimal Gland Extra Cellular Matrix from Healthy (BALB/C) and Diseased (NOD) Mice
Schenke-Layland,K., Xie,J., Angelis,E., Starcher,B., Wu,K., Riemann,I., MacLellan,W.R. and Hamm-Alvarez,S.F.
(2008) Increased degradation of extracellular matrix structures of lacrimal glands implicated in the
pathogenesis of Sjögren's syndrome. Matrix Biology, 27, 53-66.
Human Anterior Cruciate Ligament Cell and T-Lymphocyte Cultures
Seo,Y.K., Yoon,H.H., Song,K.Y., Kwon,S.Y., Lee,H.S., Park,Y.S. and Park,J.K. (2008) Increase in cell migration and
angiogenesis in a composite silk scaffold for tissue-engineered ligaments. Journal of Orthopaedic Research:
doi:1002/jor.20752.
Mouse Model of Dermal Fibrosis
Shibusawa,Y., Negishi,I., Tabata,Y. and Ishikawa,O. (2008) Mouse model of dermal fibrosis induced by one-time
injection of bleomycin-poly (L-lactic acid) microspheres. Rheumatology, 47, 454-457.
Several Tumor Cell Lines
Shimazaki,M. and Kudo,A. (2008) Impaired capsule formation of tumors in periostin-null mice. Biochemical and
Biophysical Research Communications, 367, 736-742.
Murine Lung Tissue
Shofer,S., Badea,C., Qi,Y., Potts,E., Foster,W.M. and Johnson,G.A. (2008) A micro-CT analysis of murine lung
recruitment in bleomycin-induced lung injury. Journal of Applied Physiology, 105, 669-677.
Murine Lung Tissue
Shvedova,A.A., Kisin,E., Murray,A.R., Johnson,V.J., Gorelik,O., Arepalli,S., Hubbs,A.F., Mercer,R.R., Keohavong,P.
and Sussman,N. (2008) Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice:
inflammation, fibrosis, oxidative stress, and mutagenesis. American Journal of Physiology- Lung Cellular
and Molecular Physiology, 295, L552-L565.
Human Fibroblast Cultures from Healthy Patients and Patients with Systemic Sclerosis (SSC)
Skhirtladze,C., Distler,O., Dees,C., Akhmetshina,A., Busch,N., Venalis,P., Zwerina,J., Spriewald,B., Pileckyte,M.
and Schett,G. (2008) Src kinases in systemic sclerosis: Central roles in fibroblast activation and in skin
fibrosis. Arthritis and Rheumatism, 58, 1475-1484.
Cultured Mesangial Cells
Song,H.K., Lee,M.H., Kim,B.K., Park,Y.G., Ko,G.J., Kang,Y.S., Han,J.Y., Han,S.Y., Han,K.H. and Kim,H.K. (2008)
Visfatin: A New Player in Mesangial Cell Physiology and Diabetic Nephropathy. American Journal of
Physiology- Renal Physiology, doi:10:1152/ajprenal.90231.2008.
Osteoblasts
Souza,D.M., Andrade,A.L., Fabris,J.D., Valério,P., Góes,A.M., Leite,M.F. and Domingues,R.Z. (2008) Synthesis and
in vitro evaluation of toxicity of silica-coated magnetite nanoparticles. Journal of Non-Crystalline Solids,
354, 4894-4897.
Primary Cultures of Dermal Papilla Cells, Dermal Sheath Cells and Interfollicular Dermal Fibroblasts
from Female Temporo-Occipital Scalp
Stevenson,S., Taylor,A.H., Meskiri,A., Sharpe,D.T. and Thornton,M.J. (2008) Differing responses of human follicular
and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial
growth factor secretion. Wound Repair and Regeneration, 16, 243-253.
Dermis Extracellular Matrix
Sun,W.Q. and Leung,P. (2008) Calorimetric study of extracellular tissue matrix degradation and instability after
gamma irradiation. Acta Biomaterialia, 4, 817-826.
Rat Pancreatic Stellate Cells and Rat Pancreatic Acinar Cells
Tahara,J., Shimizu,K. and Shiratori,K. (2008) Engulfment of Necrotic Acinar Cells by Pancreatic Stellate Cells
Inhibits Pancreatic Fibrogenesis. Pancreas, 37, 69-74.
Murine Lung Tissue
Tourdot,S., Mathie,S., Hussell,T., Edwards,L., Wang,H., Openshaw,P.J.M., Schwarze,J. and Lloyd,C.M. (2008)
Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of
prior allergen sensitization. Clinical & Experimental Allergy, 38, 1016-1024.
Murine Cardiac Tissue from Transgenic Mice
Ueno,M., Suzuki,J., Zenimaru,Y., Takahashi,S., Koizumi,T., Noriki,S., Yamaguchi,O., Otsu,K., Shen,W.J. and
Kraemer,F.B. (2008) Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and
fibrosis in streptozotocin diabetic mice. American Journal of Physiology- Endocrinology and Metabolism,
294, E1109-E1118.
Murine Lung Tissue
Walters, D.M. and Kleeberger, S.R. (2008) Mouse Models of Bleomycin-Induced Pulmonary Fibrosis. Current
Protocols in Pharmacology, doi: 10.1002/0471141755.ph0546s40.
Murine Lung Tissue
Wang,C., Abe,S., Matsuda,K., Yu,C., Li,Y., Usuki,J., Azuma,A. and Kudoh,S. (2008) Effects of Gefitinib on
Radiation-induced Lung Injury in Mice. Journal of Nippon Medical School, 75, 96-105.
Human Primary Lung Fibroblasts and Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis
Xia,H., Diebold,D., Nho,R., Perlman,D., Kleidon,J., Kahm,J., Avdulov,S., Peterson,M., Nerva,J. and Bitterman,P.
(2008) Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with
idiopathic pulmonary fibrosis. Journal of Experimental Medicine, doi:10.1084/jem.20080001.
Murine Lung Tissue
Yamauchi,E., Shoji,S., Nishihara,M., Shimoda,T. and Nishima,S. (2008) Contribution of Lung Fibroblast Migration in
the Fibrotic Process of Airway Remodelling in Asthma. Allergology International, 57, 73-78.
Canine Chondrocytes
Yanez,J.A., Remsberg,C.M., Vega-Villa,K.R., Miranda,N.D., Navas,J., Ohgami,Y., McCormick,D., Hughes,K.,
Temple,C. and Martinez,S.A. (2008) Pharmacological Evaluation of Glyco-Flex® III and its Constituents on
Canine Chondrocytes. Journal of Medical Sciences, 8, 98-101.
Murine Lung Tissue
Zheng,T., Liu,W., Oh,S.Y., Zhu,Z., Hu,B., Homer,R.J., Cohn,L., Grusby,M.J. and Elias,J.A. (2008) IL-13 Receptor α2
Selectively Inhibits IL-13-Induced Responses in the Murine Lung. The Journal of Immunology, 180, 522-529.
Skin
Zheng,T., Oh,M.H., Oh,S.Y., Schroeder,J.T., Glick,A.B. and Zhu,Z. (2008) Transgenic Expression of Interleukin-13 in
the Skin Induces a Pruritic Dermatitis and Skin Remodeling. Journal of Investigative Dermatology,
doi:10.1038/jid.2008.295.
2007
Dermal Fibroblasts
Ahlfors,J.E.W. and Billiar,K.L. (2007) Biomechanical and biochemical characteristics of a human fibroblast-produced
and remodeled matrix. Biomaterials, 28, 2183-2191.
Murine Vascular and Pulmonary Cells
Ambalavanan,N., LI,P., Bulger,A., Murphy-Ullrich,J., Oparil,S. and Chen,Y.F. (2007) Endothelin-1 Mediates HypoxiaInduced Increases in Vascular Collagen in the Newborn Mouse Lung. Pediatr Res, 61, 559-564.
Murine Lung Tissue
Azuma,M., Nishioka,Y., Aono,Y., Inayama,M., Makino,H., Kishi,J., Shono,M., Kinoshita,K., Uehara,H., Ogushi,F.,
Izumi,K. and Sone,S. (2007) Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib
with macrolides in mice. Am J Respir Crit Care Med., 176, 1243 – 1250.
Human Uterine Leiomyomas
Britten,J.L., Malik,M., Payson,M., Norian,J., Joseph,D. and Catherino,W.H. (2007) All-trans retinoic acid regulates
collagen synthesis in human uterine leiomyomas. Fertility and Sterility, 88, 218.
Equine Tendon-Derived Fibrillar Collagen Constructs
Butler,L.M., Metson-Scott,T., Felix,J., Abhyankar,A., Rainger,G.E., Farndale,R.W., Watson,S.P. and Nash,G.B.
(2007) Sequential adhesion of platelets and leukocytes from flowing whole blood onto a collagen-coated
surface: Requirement for a GpVI-binding site in collagen. Thromb Haemost, 97, 814-821.
Rat Lung Tissue
Chen,C.M., Wang,L.F., Chou,H.C., Lang,Y.D. and Lai,Y.P. (2007) Up-regulation of Connective Tissue Growth Factor
in Hyperoxia-Induced Lung Fibrosis. Pediatric Research, 62, 128 – 133.
Murine Osteoblastic MC3T3-E1 Cell Line
Choi,E.M. (2007) Modulatory effects of luteolin on osteoblastic function and inflammatory mediators in osteoblastic
MC3T3-E1 cells. Cell Biology International, 31, 870-877.
Choi,E.M. (2007) Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-α-induced
production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells. Pharmazie, 62, 216-220.
Choi,K.M., Yoon,H.H., Seo,Y.K., Song,K.Y., Kwon,S.Y., Lee,H.S., Park,Y.S., Kim,Y.J. and Park,J.K. (2007) Effect of
essential and nonessential amino acid compositions on the in vitro behavior of human mesenchymal stem
cells. Korean Journal of Chemical Engineering, 24, 1058-1063.
Colston,J.T., de la Rosa,S.D., Koehler,M., Gonzales,K., Mestril,R., Freeman,G.L., Bailey,S.R. and Chandrasekar,B.
(2007) Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. American
Journal of Physiology- Heart and Circulatory Physiology, 293, H1839.
Comporti,M., Signorini,C., Arezzini,B., Vecchio,D., Monaco,B. and Gardi,C. (2007) F2-isoprostanes are not just
markers of oxidative stress. Free Radical Biology and Medicine, 44, 247-256.
Mouse Lung Tissue
Denis,O., van den Brûle,S., Heymans,J., Havaux,X., Rochard,C., Huaux,F. and Huygen,K. (2007) Chronic intranasal
administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyperreactivity and remodelling. Immunology, 122, 268-278.
Human Colonic Myofibroblasts
Di Sabatino,A., Pender,S.L.F., Jackson,C.L., Prothero,J.D., Gordon,J.N., Picariello,L., Rovedatti,L., Docena,G.,
Monteleone,G. and Rampton,D.S. (2007) Functional Modulation of Crohn’s Disease Myofibroblasts by AntiTumor Necrosis Factor Antibodies. Gastroenterology, 133, 137-149.
Digel,I., Kurulgan,E., Linder,P., Kayser,P., Porst,D., Braem,G.J., Zerlin,K., Artmann,G.M. and Artmann,A.T. (2007)
Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts.
Medical and Biological Engineering and Computing, 45, 91-97.
Murine Muscle Samples
DuBay,D.A., Choi,W., Urbanchek,M.G., Wang,X., Adamson,B., Dennis,R.G., Kuzon Jr,W.M. and Franz,M.G. (2007)
Incisional Herniation Induces Decreased Abdominal Wall Compliance via Oblique Muscle Atrophy and
Fibrosis. Ann Surg, 245, 140-146.
Murine Kidney Samples
El Chaar,M., Chen,J., Seshan,S.V., Jha,S., Richardson,I., Ledbetter,S.R., Vaughan Jr,E.D., Poppas,D.P. and
Felsen,D. (2007) Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in
unilateral ureteral obstruction. American Journal of Physiology- Renal Physiology, 292, F1291-F1301.
Murine Lung Tissue
Faress,J.A., Nethery,D.E., Kern,E.F.O., Eisenberg,R., Jacono,F.J., Allen,C.L. and Kern,J.A. (2007) Bleomycin
Induced Pulmonary Fibrosis is Attenuated by a Monoclonal Antibody Targeting HER2. Journal of Applied
Physiology, 103, 2077-2083.
Murine Colon Samples
Fichtner-Feigl,S., Fuss,I.J., Young,C.A., Watanabe,T., Geissler,E.K., Schlitt,H.J., Kitani,A. and Strober,W. (2007)
Induction of IL-13 Triggers TGF-beta1-Dependent Tissue Fibrosis in Chronic 2, 4, 6-Trinitrobenzene Sulfonic
Acid Colitis. The Journal of Immunology, 178, 5859.
Leporine Mesenchymal Stem Cells
Hannouche,D., Terai,H., Fuchs,J.R., Terada,S., Zand,S., Nasseri,B.A., Petite,H., Sedel,L. and Vacanti,J.P. (2007)
Engineering of implantable cartilaginous structures from bone marrow-derived mesenchymal stem cells.
Tissue Eng. 13, 87-99.
Human Embryonic Stem Cells (hESCs) – Cell Lines H9 and BG01V
Hoben,G.M., Koay,E.J. and Athanasiou,K.A. (2007) Fibrochondrogenesis in Two Embryonic Stem Cell Lines: Effects
of Differentiation Timelines. Stem Cells, 26, 422- 430.
Murine Liver Tissues
Hsu,Y.C., Chiu,Y.T., Cheng,C.C., Wu,C.F., Lin,Y.L. and Huang,Y.T. (2007) Antifibrotic effects of tetrandrine on
hepatic stellate cells and rats with liver fibrosis. Journal of Gastroenterology and Hepatology, 22, 99-111.
Human Primary Keloid Fibroblast Culture Supernatant
Hsu,Y.C., Hsiao,M., Chien,Y.W. and Lee,W.R. (2007) Exogenous nitric oxide stimulated collagen type I expression
and TGF-β1 production in keloid fibroblasts by a cGMP-dependent manner. Nitric Oxide, 16, 258-265.
Murine Pulmonary Lysates, Macrophage Cell Line RAW 264.7 and Human Normal Lung Fibroblast MRC-5
Cell Line
Hsu,Y.C., Wang,L.F. and Chien,Y.W. (2007) Nitric oxide in the pathogenesis of diffuse pulmonary fibrosis. Free
Radical Biology and Medicine, 42, 599-607.
Human Primary Fibroblast Culture and Murine Dermal Tissue Samples
Huber,L.C., Distler,J.H., Moritz,F., Hemmatazad,H., Hauser,T., Michel,B.A., Gay,R.E., Matucci-Cerinic,M., Gay,S.
and Distler,O. (2007) Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of
bleomycin-induced skin fibrosis. Arthritis Rheum, 56, 2755-2764.
Murine Bladder Tissue
Imamura,M., Kanematsu,A., Yamamoto,S., Kimura,Y., Kanatani,I., Ito,N., Tabata,Y. and Ogawa,O. (2007) Basic
fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle
cells. American Journal of Physiology- Renal Physiology, 293, F1007-F1017.
Dog Cardiovascular Tissue
Jugdutt,B.I., Idikio,H. and Uwiera,R.R.E. (2007) Angiotensin receptor blockade and angiotensin-converting-enzyme
inhibition limit adverse remodeling of infarct zone collagens and global diastolic dysfunction during healing
after reperfused ST-elevation myocardial infarction. Molecular and Cellular Biochemistry, 303, 27-38.
Murine Lung Tissue
Kai,Y., Yoneyama,H., Koyama,J., Hamada,K., Kimura,H. and Matsushima,K. (2007) Treatment with chondroitinase
ABC alleviates bleomycin-induced pulmonary fibrosis. Medical Molecular Morphology, 40, 128-140.
Murine Pancreatic Stellate Cells
Kaku,T., Oono,T., Zhao,H., Gibo,J., Kawabe,K., Ito,T. and Takayanagi,R. (2007) IS-741 Attenuates Local Migration
of Monocytes and Subsequent Pancreatic Fibrosis in Experimental Chronic Pancreatitis Induced by Dibutyltin
Dichloride in Rats. Pancreas, 34, 299-309.
Murine Lung Homogenates
Kang,H.R., Lee,C.G., Homer,R.J. and Elias,J.A. (2007) Semaphorin 7A plays a critical role in TGF-β1-induced
pulmonary fibrosis. J. Exp. Med., 204, 1083.
Murine Lung Tissue
Kang,H.R., Cho,S.J., Lee,C.G., Homer,R.J. and Elias,J.A. (2007) TGF-beta 1 stimulates pulmonary fibrosis and
inflammation via a bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.
Journal of Biological Chemistry, 282, 7723-7732.
Murine Lung Tissue
Kanno,Y., Kuroki,A., Okada,K., Tomogane,K., Ueshima,S., Matsuo,O. and Matsuno,H. (2007) α2-Antiplasmin is
involved in the production of transforming growth factor β1 and fibrosis. Journal of Thrombosis and
Haemostasis, 5, 2266-2273.
Human Stem Cells
Kim,S.G., Jeon,C.H., Suh,H., Choe,J.Y. and Shin,I.H. (2007) P-glycoprotein expression in extracellular matrix
formation of chondrogenic differentiation of human adult stem cells. Cell Biology International, 31, 10421048.
Human Myocardial Samples
Klotz,S., Danser,A.H., Foronjy,R.F., Oz,M.C., Wang,J., Mancini,D., D'Armiento,J. and Burkhoff,D. (2007) The Impact
of Angiotensin-Converting Enzyme Inhibitor Therapy on the Extracellular Collagen Matrix During Left
Ventricular Assist Device Support in Patients With End-Stage Heart Failure. Journal of the American College
of Cardiology, 49, 1166.
Murine Lung Tissue
Kohan, M., Bader,R., Puxeddu,I., Levi-Schaffer,F., Breuer,R. and Berkman,N. (2007) Enhanced osteopontin
expression in a murine model of allergen-induced airway remodelling. Clinical & Experimental Allergy, 37,
1444-1454.
Ovine Mesenchymal Progenitor Cells
Kunisaki,S.M., Fuchs,J.R., Steigman,S.A. and Fauza,D.O. (2007) A comparative analysis of cartilage engineered from
different perinatal mesenchymal progenitor cells. Tissue Eng. 13, 2633 – 2644.
Human Fibroblast Cell Lines
Lareu,R.R., Arsianti,I., Subramhanya,H.K., Yanxian,P., Raghunath,M. (2007) In vitro enhancement of collagen
matrix formation and crosslinking for applications in tissue engineering; a preliminary study. Tissue Eng.
13, 385-391.
Murine Cementoblastic Cell Line, OCCM-30
La-Bona,D.A., Tanaka,E., Inubushi,T., Oka,H., Ohta,A., Okada,H., Miyauchi,M., Takata,T. and Tanne,K. (2007)
Cementoblast response to low-and high-intensity ultrasound. Archives of Oral Biology, 53, 318-323.
Ovine Bone Marrow Mesenchymal Cells
Luo,Z.J. and Seedhom,B.B. (2007) Light and low-frequency pulsatile hydrostatic pressure enhances extracellular
matrix formation by bone marrow mesenchymal cells: an in-vitro study with special reference to cartilage
repair. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine,
221, 499-507.
Murine Lung Tissue
Maret,M., Ruffie,C., Periquet,B., Campo,A.M., Menevret,M., Phelep,A., Dziewiszek,K., Druilhe,A. and Pretolani,M.
(2007) Liposomal Retinoic Acids Modulate Asthma Manifestations in Mice. Journal of Nutrition, 137, 2730 –
2736.
Murine Dermal Biopsies
Matsushita,T., Fujimoto,M., Hasegawa,M., Matsushita,Y., Komura,K., Ogawa,F., Watanabe,R., Takehara,K. and
Sato,S. (2007) BAFF Antagonist Attenuates the Development of Skin Fibrosis in Tight-Skin Mice. Journal of
Investigative Dermatology, 127, 2772-2780.
Murine Lung Tissue
Mishra,A., Wang,M., Schlotman,J., Nikolaidis,N.M., DeBrosse,C.W., Karow,M.L. and Rothenberg,M.E. (2007)
Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in
the murine lung. American Journal of Physiology- Lung Cellular and Molecular Physiology, 293, L305.
Misson,P., Brombacher,F., Delos,M., Lison,D. and Huaux,F. (2007) Type 2 immune response associated with silicosis
is not instrumental in the development of the disease. American Journal of Physiology- Lung Cellular and
Molecular Physiology, 292, L107-L113.
Morschl,E., Volmer,J.B., Molina,J.G., Lee,J.J., Ochkur,S.I. and Blackburn,M.R. (2007) A3 Adenosine Receptors
Modulate Eosinophil Function In Bleomycin-Induced Lung Injury. The Journal of Allergy and Clinical
Immunology, 119, 218.
Murine Fibroblast NIH3T3 Cell Line
Nishi,Y., Sano,H., Kawashima,T., Okada,T., Kuroda,T., Kikkawa,K., Kawashima,S., Tanabe,M., Goto,T. and
Matsuzawa,Y. (2007) Role of Galectin-3 in Human Pulmonary Fibrosis. Allergology International, 1, 57-65.
Murine Lung Tissue
Niu,N., Le Goff,M.K., Li,F., Rahman,M., Homer,R.J. and Cohn,L. (2007) A Novel Pathway That Regulates
Inflammatory Disease in the Respiratory Tract. The Journal of Immunology, 178, 3846.
Nomiyama,Y., Tashiro,M., Yamaguchi,T., Watanabe,S., Taguchi,M., Asaumi,H., Nakamura,H. and Otsuki,M. (2007)
High Glucose Activates Rat Pancreatic Stellate Cells Through Protein Kinase C and p38 Mitogen-Activated
Protein Kinase Pathway. Pancreas, 34, 364-372.
Human Epithelial Cells
Ornatowski,W., Poschet,J.F., Perkett,E., Taylor-Cousar,J.L. and Deretic,V. (2007) Elevated furin levels in human
cystic fibrosis cells result in hypersusceptibility to exotoxin A induced cytotoxicity. Journal of Clinical
Investigation, 117, 3489.
Murine Primary Osteoblasts
Orriss,I.R., Utting,J.C., Brandao-Burch,A., Colston,K., Grubb,B.R., Burnstock,G. and Arnett,T.R. (2007)
Extracellular Nucleotides Block Bone Mineralization in Vitro: Evidence for Dual Inhibitory Mechanisms
Involving Both P2Y2 Receptors and Pyrophosphate. Endocrinology, 148, 4208.
Murine Pulmonary Tissue
Pena,A.M., Fabre,A., Débarre,D., Marchal-Somme,J., Crestani,B., Martin,J.L., Beaurepaire,E. and SchanneKlein,M.C. (2007) Three-dimensional investigation and scoring of extracellular matrix remodeling during
lung fibrosis using multiphoton microscopy. Microsc.Res.Tech. 70, 162 – 170.
Murine Lung Tissue
Pilling,D., Roife,D., Wang,M., Ronkainen,S.D., Crawford,J.R., Travis,E.L. and Gomer,R.H. (2007) Reduction of
Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P. The Journal of Immunology, 179, 4035.
Human Primary Fetal and Postnatal Dermal Fibroblasts
Rolfe,K., Grobbelaar,A.O. and Linge,C. (2007) Is TGF-B1 signalling active in fetuses? Journal of Plastic,
Reconstructive & Aesthetic Surgery, 60, S11.
Human Fetal and Postnatal Fibroblasts
Rolfe,K.J., Richardson,J., Vigor,C., Irvine,L.M., Grobbelaar,A.O. and Linge,C. (2007) A Role for TGF-bold italic beta
1-Induced Cellular Responses during Wound Healing of the Non-Scarring Early Human Fetus? Journal of
Ovine Blood-Derived Endothelial Progenitor Cells
Sales,V.L., Engelmayr Jr,G.C., Johnson Jr,J.A., Gao,J., Wang,Y., Sacks,M.S. and Mayer Jr,J.E. (2007) Protein
Precoating of Elastomeric Tissue-Engineering Scaffolds Increased Cellularity, Enhanced Extracellular Matrix
Protein Production, and Differentially Regulated the Phenotypes of Circulating Endothelial Progenitor Cells.
Circulation, 116, 155-163.
Rat Choloangiocytes
Sato,Y., Harada,K., Ozaki,S., Furubo,S., Kizawa,K., Sanzen,T., Yasoshima,M., Ikeda,H., Sasaki,M. and Nakanuma,Y.
(2007) Cholangiocytes with Mesenchymal Features Contribute to Progressive Hepatic Fibrosis of the
Polycystic Kidney Rat. American Journal of Pathology, 171, 1859 – 1871.
Equine Flexor Digitorum Superficialis Tendon (SDFT) Explants
Schnabel,L.V., Mohammed,H.O., Miller,B.J., McDermott,W.G., Jacobson,M.S., Santangelo,K.S. and Fortier,L.A.
(2007) Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum
superficialis tendons. J Orthop Res, 25, 230-240.
Murine Lung Tissue
Shvedova,A.A., Kisin,E.R., Murray,A.R., Gorelik,O., Arepalli,S., Castranova,V., Young,S.H., Gao,F., Tyurina,Y.Y.,
Oury,T.D. and Kagan,V.E. (2007) Vitamin E deficiency enhances pulmonary inflammatory response and
oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicology and Applied
Swain,S.D., Han,S., Harmsen,A., Shampeny,K. and Harmsen,A.G. (2007) Pulmonary Hypertension Can Be a Sequela
of Prior Pneumocystis Pneumonia. American Journal of Pathology, 171, 790-799.
Murine Sponge Implants
Tkalcević,V.I., Cuzić,S., Brajsa,K., Mildner,B., Bokulić,A., Situm,K., Perović,D., Glojnarić,I. and Parnham,M.J.
(2007) Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the
potential role of egr-1 expression. European Journal of Pharmacology, 570, 212-221.
Vittal,R., Zhang,H., Han,M.L.K., Moore,B.B., Horowitz,J.C. and Thannickal,V.J. (2007) Effects of the Protein Kinase
Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic
Diseases. Journal of Pharmacology and Experimental Therapeutics, 321, 35-44.
Murine Lung Tissue
Wallach-Dayan,S.B., Golan-Gerstl,R. and Breuer,R. (2007) Evasion of myofibroblasts from immune surveillance: A
mechanism for tissue fibrosis. Proceedings of the National Academy of Sciences, 104, 20460.
Leporine Chondrocyte
Xie,J.U.N., Han,Z., Kim,S.O.O.H., Kim,Y.H.A. and Takehisa Matsuda,P.D. (2007) Mechanical Loading-Dependence of
mRNA Expressions of Extracellular Matrices of Chondrocytes Inoculated into Elastomeric Microporous Poly
(L-lactide-co-e-caprolactone) Scaffold. Tissue Engineering, 13, 29-40.
Bovine Decellularised Vocal Fold Lamina and Human Vocal Fold Fibroblast Primary Culture
Xu,C.C., Chan,R.W. and Tirunagari,N. (2007) A Biodegradable, Acellular Xenogeneic Scaffold for Regeneration of
the Vocal Fold Lamina Propria. Tissue Engineering, 13, 551-566.
Murine Dermal Biopsy
Yamamoto,T., Yokozeki,H. and Nishioka,K. (2007) Fas-and FasL-deficient mice are resistant to the induction of
bleomycin-induced scleroderma. Archives of Dermatological Research, 298, 465-468.
Murine Dermal Tissue
Yoshioka,T., Imura,K., Hikita,I., Hirasawa,T., Sakata,T., Matsutani,T., Horikawa,T. and Arimura,A. (2007) Impact of
T-cell receptor V haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of
interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus.
Murine Lung Tissue
Young,L.R., Pasula,R., Gulleman,P.M., Deutsch,G.H. and McCormack,F.X. (2007) Susceptibility of Hermansky-Pudlak
Mice to Bleomycin-Induced Type II Cell Apoptosis and Fibrosis. Am J Respir Cell Mol Biol, 37 67 – 74.
2006
Murine Pacreatic Stellate Cells
Asaumi,H., Watanabe,S., Taguchi,M., Tashiro,M., Nagashio,Y., Nomiyama,Y., Nakamura,H. and Otsuki,M. (2006)
Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits ethanol-induced activation of pancreatic
stellate cells. European Journal of Clinical Investigation, 36, 113-122.
Leporine cartilage and Chondrocyte Explants
Baek,Y.H., Huh,J.E., Lee,J.D., Choi,D.Y. and Park,D.S. (2006) Effect of Aralia cordata Extracts on Cartilage
Protection and Apoptosis Inhibition. Biological & Pharmaceutical Bulletin, 29, 1423-1430.
Porcine Aortic Valves
Balachandran,K., Konduri,S., Sucosky,P., Jo,H. and Yoganathan,A.P. (2006) An Ex Vivo Study of the Biological
Properties of Porcine Aortic Valves in Response to Circumferential Cyclic Stretch. Annals of Biomedical
Engineering, 34, 1655-1665.
Human Articular Chondrocytes
Banu,N., Tsuchiya,T. and Sawada,R. (2006) Effects of a biodegradable polymer synthesized with inorganic tin on the
chondrogenesis of human articular chondrocytes. J Biomed Mater Res A. 77, 84-89.
Murine Collagen Deposition on Polypropylene Tapes
Bogusiewicz,M., Wrobel,A., Jankiewicz,K., Adamiak,A., Skorupski,P., Tomaszewski,J. and Rechberger,T. (2006)
Collagen deposition around polypropylene tapes implanted in the rectus fascia of female rats. European
Journal of Obstetrics & Gynecology and Reproductive Biology, 124, 106-109.
Human Ventricular Tissue Samples
Bruggink,A.H., van Oosterhout,M.F.M., de Jonge,N., Ivangh,B., van Kuik,J., Voorbij,R.H.A.M., Cleutjens,J.P.M.,
Gmelig-Meyling,F.H.J. and de Weger,R.A. (2006) Reverse Remodeling of the Myocardial Extracellular Matrix
After Prolonged Left Ventricular Assist Device Support Follows a Biphasic Pattern. Journal of Heart and
Lung Transplantation, 25, 1091-1098.
Chan,E.S.L., Fernandez,P., Merchant,A.A., Montesinos,M.C., Trzaska,S., Desai,A., Tung,C.F., Khoa,D.N.,
Pillinger,M.H. and Reiss,A.B. (2006) Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in
human dermal fibroblasts and in a murine model of scleroderma. Arthritis & Rheumatism, 54, 2632-2642.
Murine Lung Samples
Cho,S.J., Kang,M.J., Homer,R.J., Kang,H.R., Zhang,X., Lee,P.J., Elias,J.A. and Lee,C.G. (2006) Role of Early
Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling. Journal of Biological
Chemistry, 281, 8161.
Leporine Articular Cartilage
Cho,Y.J., Huh,J.E., Kim,D.Y., Kim,N.J., Lee,J.D., Baek,Y.H., Cho,E.M., Yang,H.R., Choi,D.Y. and Park,D.S. (2006)
Effect of Betula platyphylla var. japonica on Proteoglycan Release, Type II Collagen Degradation, and Matrix
Metalloproteinase Expression in Rabbit Articular Cartilage Explants. Biological & Pharmaceutical Bulletin,
29, 1408-1413.
Murine Hepatic Stellate Cells HSC-T6 and Liver Samples
Chong,L.W., Hsu,Y.C., Chiu,Y.T., Yang,K.C. and Huang,Y.T. (2006) Anti-Fibrotic Effects of Thalidomide on Hepatic
Stellate Cells and Dimethylnitrosamine-Intoxicated Rats. Journal of Biomedical Science, 13, 403-418.
Murine Liver Tissue
Chou,W-Y., Lu,C-n., Lee,T-h., Wu,C-l., Hung,K-s., Concejero,A.M., Jawan,B. and Wang,C-h. (2006) Electroporative
interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and
TIMP modulation. Acta Pharmacologica Sinica 27, 469-476.
Murine Bronchial Lavages
Chunn,J.L., Mohsenin,A., Young,H.W.J., Lee,C.G., Elias,J.A., Kellems,R.E. and Blackburn,M.R. (2006) Partially
adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations.
American Journal of Physiology- Lung Cellular and Molecular Physiology, 290, 579-587.
Distler,J.H., Jüngel,A., Caretto,D., Schulze-Horsel,U., Kowal-Bielecka,O., Gay,R.E., Michel,B.A., Müller-Ladner,U.,
Kalden,J.R., Gay,S. and Distler,O. (2006) Monocyte chemoattractant protein 1 released from
glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4
from T cells. Arthritis Rheum, 54, 214-225.
Distler,J.H., Jüngel,A., Huber,L.C., Schulze-Horsel,U., Zwerina,J., Gay,R.E., Michel,B.A., Hauser,T., Schett,G. and
Gay,S. (2006) Imatinib mesylate reduces production of extracellular matrix and prevents development of
experimental dermal fibrosis. Arthritis Rheum, 56, 311-322.
Murine Abdominal Wall Samples
DuBay,D.A., Wang,X., Adamson,B., Kuzon,W.M., Dennis,R.G. and Franz,M.G. (2006) Mesh incisional herniorrhaphy
increases abdominal wall elastic properties: A mechanism for decreased hernia recurrences in comparison
with suture repair. Surgery, 140, 14-24.
Human Normal and Keloid Fibroblasts
Duong,H.S., Zhang,Q.Z., Le,A.D., Kelly,A.P., Kamdar,R. and Messadi,D.V. (2006) Elevated prolidase activity in
keloids: correlation with type I collagen turnover. Br J Dermatol 154, 820-828.
Ovine Bone Marrow-Derived Mesenchymal Stem Cells
Engelmayr Jr,G.C., Sales,V.L., Mayer Jr,J.E. and Sacks,M.S. (2006) Cyclic flexure and laminar flow synergistically
accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart
valve tissues. Biomaterials, 27, 6083-6095.
Murine Lung Samples
Fichtner-Feigl,S., Strober,W., Kawakami,K., Puri,R.K. and Kitani,A. (2006) IL-13 signaling through the IL-13α2
receptor is involved in induction of TGF-β production and fibrosis. Nature Medicine, 12, 99-106.
Fujimoto, H., Gabazza, E. C., Taguchi, O., Nishii, Y., Nakahara, H., Bruno, N. E., Alessandro-Gabazza, C. N.,
Kasper, M., Yano, Y., and Nagashima, M. (2006) Thrombin-Activatable Fibrinolysis Inhibitor Deficiency
Attenuates Bleomycin-Induced Lung Fibrosis. American Journal of Pathology 168, 1086-1096.
Porcine Aortic Smooth Muscle Cells
Gavish,L., Perez,L. and Gertz,S.D. (2006) Low-level laser irradiation modulates matrix metalloproteinase activity
and gene expression in porcine aortic smooth muscle cells. Lasers Surg Med., 38, 779-786.
Porcine Bone Marrow Stromal Cells
Goh,J.C.H., Te Tay,P.D. and Sl Toh,P.D. (2006) Characterization of a Novel Polymeric Scaffold for Potential
Application in Tendon/Ligament Tissue Engineering. Tissue Engineering, 12, 91-99.
Murine Mesangial and Proximal Tubular Cell Culture Supernatants
Han,K.H., Kang,Y.S., Han,S.Y., Jee,Y.H., Lee,M.H., Han,J.Y., Kim,H.K., Kim,Y.S. and Cha,D.R. (2006)
Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic
rats. Kidney International, 70, 111-120.
Human Kidney-2 Cell Culture Supernatants
Han,S.Y., Jee,Y.H., Han,K.H., Kang,Y.S., Kim,H.K., Han,J.Y., Kim,Y.S. and Cha,D.R. (2006) An imbalance between
matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the
development of early diabetic nephropathy. Nephrology Dialysis Transplantation, 21, 2406.
Human Keratinocyte and Fibroblast Artificial Dermis
Harrison,C.A., Gossiel,F., Layton,C.M., Bullock,A.J., Johnson,T., Ubrey Blumsohn,P.D. and Sheila Macneil,P.D.
(2006) Use of an in Vitro Model of Tissue-Engineered Skin to Investigate the Mechanism of Skin Graft
Contraction. Tissue Engineering, 12, 3119-3113.
Leporine Temporomandibular Joint Disc Fibrocartilage, Knee Meniscus Fibrocartilage, Knee Articular
Cartilage and Pubic Symphysis
Hashem,G., Zhang,Q., Hayami,T., Chen,J., Wang,W. and Kapila,S. (2006) Relaxin and β-estradiol modulate targeted
matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis
Res Ther., 8, R98.
Equine Superficial Digital Flexor Tendon in Explant Culture
Haupt,JL., Donnelly,BP. and Nixon,AJ. (2006) Effects of platelet-derived growth factor-BB on the metabolic
function and morphologic features of equine tendon in explants culture. Am J Vet Res, 67, 1595-1600.
Human Osteoblast-Like SaOS-2 Cell Line
Huh,J.E., Yang,H.R., Park,D.S., Choi,D.Y., Baek,Y.H., Cho,E.M., Cho,Y.J., Kang-Il,K., Kim,D.Y. and Lee,J.D. (2006)
Puerariae radix promotes differentiation and mineralization in human osteoblast-like SaOS-2 cells. J
Ethnopharmacol, 104, 345-350.
Murine Pulmonary Myofibroblasts
Izumi,N., Mizuguchi,S., Inagaki,Y., Saika,S., Kawada,N., Nakajima,Y., Inoue,K., Suehiro,S., Friedman,S.L. and
Ikeda,K. (2006) BMP-7 opposes TGF-β1-mediated collagen induction in mouse pulmonary myofibroblasts
through Id2. American Journal of Physiology- Lung Cellular and Molecular Physiology, 290, 120-126.
Jacono,F.J., Peng,Y.J., Nethery,D., Faress,J.A., Lee,Z., Kern,J.A. and Prabhakar,N.R. (2006) Acute lung injury
augments hypoxic ventilatory response in the absence of systemic hypoxemia. Journal of Applied
Physiology, 101, 1795.
Kato,T., Okahashi,N., Ohno,T., Inaba,H., Kawai,S. and Amano,A. (2006) Effect of phenytoin on collagen
accumulation by human gingival fibroblasts exposed to TNF-ain vitro. Oral Diseases, 12, 156-162.
Human Alveolar Epithelial (A549) and Akata Cell Lines
Keating,D.T., Sadlier,D.M., Patricelli,A., Smith,S.M., Walls,D., Egan,J.J. and Doran,P.P. (2006) Microarray identifies
ADAM family members as key responders to TGF-beta 1 in alveolar epithelial cells. Respiratory Research, 7,
114.
Murine Kidneys
Kellner,D., Chen,J., Richardson,I., Seshan,S.V., EL Chaar,M., Vaughan Jr,E.D., Poppas,D. and Felsen,D. (2006)
Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral
ureteral obstruction. J Urol, 176, 806-812.
Kushibiki,T., Nagata-Nakajima,N., Sugai,M., Shimizu,A. and Tabata,Y. (2006) Enhanced anti-fibrotic activity of
plasmid DNA expressing small interference RNA for TGF-beta type II receptor for a mouse model of
obstructive nephropathy by cationized gelatin prepared from different amine compounds. J Control
Release, 110, 610-617.
Murine Tracheal Homogenates
Lama,V.N., Harada,H., Badri,L.N., Flint,A., Hogaboam,C.M., McKenzie,A., Martinez,F.J., Toews,G.B., Moore,B.B.
and Pinsky,D.J. (2006) Obligatory Role for Interleukin-13 in Obstructive Lesion Development in Airway
Allografts. American Journal of Pathology, 169, 47.
Human ER-Positive Breast Cancer MCF-7 Cell Line and Murine Osteoblast-Like MC3T3-E1 Cell Line
Lee,K.H. and Choi,E.M. (2006) Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume
on the function of osteoblastic MC3T3-E1 cells. Phytother.Res, 20, 952-960.
Murine Osteoblast-Like MC3T3-E1 Cell Line
Lee,K.H. and Choi,E.M. (2006) Rubus coreanus Miq. Extract Promotes Osteoblast Differentiation and Inhibits BoneResorbing Mediators in MC3T3-E1 Cells. The American Journal of Chinese Medicine, 34, 643-654.
Lee,K.S., Park,S.J., Kim,S.R., Min,K.H., Jin,S.M., Lee,H.K. and Lee,Y.C. (2006) Modulation of Airway Remodeling
and Airway Inflammation by Peroxisome Proliferator-Activated Receptor γ in a Murine Model of Toluene
Diisocyanate-Induced Asthma. The Journal of Immunology, 177, 5248.
Murine Liver Tissue
Lee,T.H., Jawan,B., Chou,W.Y., Lu,C.N., Wu,C.L., Kuo,H.M., Concejero,A.M. and Wang,C.H. (2006) alphaMelanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice.
J Gene Med, 8, 764-772.
Lee,J.H., Roh,M.R. and Lee,K.H. (2006) Effects of Infrared Radiation on Skin Photo-Aging and Pigmentation. Yonsei
Med J., 47, 485-490.
Murine Bone Marrow Stromal Cells and Osteoblasts
Leivo,J., Meretoja,V., Vippola,M., Levanen,E., Vallittu,P. and Mantyla,T.A. (2006) Sol-gel derived aluminosilicate
coatings on alumina as substrate for osteoblasts. Acta Biomater. 2, 659-668.
Li,B., Chen,J. and James,H.C.W. (2006) RGD peptide-conjugated poly (dimethylsiloxane) promotes adhesion,
proliferation, and collagen secretion of human fibroblasts. Mater Res, 79, 989-998.
Lijnen,P., Papparella,I., Petrov,V., Semplicini,A. and Fagard,R. (2006) Angiotensin II-stimulated collagen production
in cardiac fibroblasts is mediated by reactive oxygen species. J Hypertens, 24, 757-766.
Murine Hepatocytes and Hepatic Stellate Cells
Lin,Y.L., Wu,C.H., Luo,M.H., Huang,Y.J., Wang,C.N., Shiao,M.S. and Huang,Y.T. (2006) In vitro protective effects
of salvianolic acid B on primary hepatocytes and hepatic stellate cells. Journal of Ethnopharmacology, 105,
215-222.
Murine Lung Tissue
Liu,H., Liu,L., Fletcher,B.S. and Visner,G.A. (2006) Sleeping Beauty-based gene therapy with indoleamine 2, 3dioxygenase inhibits lung allograft fibrosis. The FASEB Journal, 20, 2384.
Murine Lung Tissue
Lopez,E., del Pozo,V., Miguel,T., Sastre,B., Seoane,C., Civantos,E., Llanes,E., Baeza,M.L., Palomino,P. and
Cardaba,B. (2006) Inhibition of Chronic Airway Inflammation and Remodeling by Galectin-3 Gene Therapy in
a Murine Model 1. The Journal of Immunology, 176, 1943-1950.
Murine Lung Tissue
Ma,B., Blackburn,M.R., Lee,C.G., Homer,R.J., Liu,W., Flavell,R.A., Boyden,L., Lifton,R.P., Sun,C.X. and
Young,H.W. (2006) Adenosine metabolism and murine strain-specific IL-4-induced inflammation,
emphysema, and fibrosis. Journal of Clinical Investigation, 116, 1274-1283.
Human Dermal Fibroblast Primary and CRL-2127 Cell Cultures
Makareeva,E., Cabral,W.A., Marini,J.C. and Leikin,S. (2006) Molecular Mechanism of Alpha 1(I)-Osteogenesis
Imperfecta/Ehlers-Danlos Syndrome: Unfolding of an N-Anchor Domain at the N-Terminal End of the Type I
Collagen Triple Helix. Journal of Biological Chemistry, 281, 6463.
Murine Lung Tissue
Manoury,B., Nenan,S., Guenon,I., Boichot,E., Planquois,J.M., Bertrand,C.P. and Lagente,V. (2006) Macrophage
metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice. J
Inflamm (Lond), 3, 2.
McFarlin,K., Gao,X., Liu,Y.B., Dulchavsky,D.S., Kwon,D., Arbab,A.S., Bansal,M., Li,Y., Chopp,M. and
Dulchavsky,S.A. (2006) Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the
rat. Wound Repair and Regeneration, 14, 471-478.
Leporine Bone Marrow-Derived Mesenchymal Stem Cells
Medrado,G.C.B., Machado,C.B., Valerio,P., Sanches,M.D. and Goes,A.M. (2006) The effect of a chitosan-gelatin
matrix and dexamethasone on the behavior of rabbit mesenchymal stem cells. Biomedical Materials, 1,
155-161.
Murine Rectal Tissue
Motomura,Y., Khan,W.I., El-Sharkawy,R.T., Verma-Gandhu,M., Verdu,E.F., Gauldie,J. and Collins,S.M. (2006)
Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein
1. Gut, 55, 662-670.
Human Lung Fibroblastic Cell Line TIG-3-20
Nagano, J., Iyonaga, K., Kawamura, K., Yamashita, A., Ichiyasu, H., Okamoto, T., Suga, M., Sasaki, Y., and Kohrogi,
H. (2006) Use of tacrolimus, a potent antifibrotic agent, in bleomycin-induced lung fibrosis. European
Respiratory Journal, 27, 460-469.
Narita,Y., Nomura,J., Ohta,S., Inoh,Y., Suzuki,K.M., Araki,Y., Okada,S., Matsumoto,I., Isohama,Y. and Abe,K.
(2006) Royal Jelly Stimulates Bone Formation: Physiologic and Nutrigenomic Studies with Mice and Cell
Lines. Bioscience, Biotechnology, and Biochemistry, 70, 2508-2514.
Murine Lung Tissue
Oikonomou,N., Harokopos,V., Zalevsky,J., Valavanis,C., Kotanidou,A., Szymkowski,D.E., Kollias,G. and Aidinis,V.
(2006) Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis. PLoS ONE, 1, e108.
Murine Osteoblast Primay Cultures
Oktar,F.N., Valério,P., Goller,G., Agathopoulos,S., Goes,A.M. and Leite,M.F. (2006) Biocompatibility of the Outer
Prismatic and the Inner Nacreous Layers of Four Different Molluscs. Key Engineering Materials, 309, 449.
Human Ligament Fibroblasts Primary Culture
Park,S.A., Kim,I.A., Lee,Y.J., Shin,J.W., Kim,C.R., Kim,J.K., Yang,Y.I. and Shin,J.W. (2006) Biological Responses of
Ligament Fibroblasts and Gene Expression Profiling on Micropatterned Silicone Substrates Subjected to
Mechanical Stimuli. Journal of Bioscience and Bioengineering, 102, 402-412.
Murine Hepatic Stellate Cells
Patella,S., Phillips,D.J., Tchongue,J., de Kretser,D.M. and Sievert,W. (2006) Follistatin attenuates early liver
fibrosis: effects on hepatic stellate cell activation and hepatocyte apoptosis. American Journal of
Physiology- Gastrointestinal and Liver Physiology, 290, 137-144.
Human Fibroblast HFL-1 and Epithelial A549 Cell Line Co-Cultures
Phillips,R.J., Blatt,L.M. and Ozes,O.N. (2006) Pirfenidone and Interferon Gamma-1b Inhibit the Profibrotic Effects
of Osteopontin. Chest, 130, 229S.
Murine Lung Tissue
Polte,T., Foell,J., Werner,C., Hoymann,H.G., Braun,A., Burdach,S., Mittler,R.S. and Hansen,G. (2006) CD137mediated immunotherapy for allergic asthma. Journal of Clinical Investigation, 116, 1025-1036.
Human Mesenchymal Populations and Articular Chondrocytes
Pound,J.C., Green,D.W., Chaudhuri,J.B., Mann,S., Roach,H.I. and Oreffo,R.O.C. (2006) Strategies to Promote
Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chondrocytes Encapsulated
in Polysaccharide Templates. Tissue Engineerig, 12, 2789-2799.
Reyes,M., Steinhelper,M.E., Alvarez,J.A., Escobedo,D., Pearce,J., Valvano,J.W., Pollock,B.H., Wei,C.L., Kottam,A.
and Altman,D. (2006) Impact of physiological variables and genetic background on myocardial frequencyresistivity relations in the intact beating murine heart. American Journal of Physiology- Heart and
Circulatory Physiology, 291, H1659.
Murine Fibroblast and Macrophage Co-Cultures
Saika, S., Ikeda, K., Yamanaka, O., Flanders, K. C., Okada, Y., Miyamoto, T., Kitano, A., Ooshima, A., Nakajima,
Y., and Ohnishi, Y. (2006) Loss of Tumor Necrosis Factor α Potentiates Transforming Growth Factor βmediated Pathogenic Tissue Response During Wound Healing. American Journal of Pathology 168, 18481860.
Ovine Blood-Derived Endothelial Progenitor Cells
Sales,V.L., Engelmayr Jr,G.C., Mettler,B.A., Johnson Jr,J.A., Sacks,M.S. and Mayer Jr,J.E. (2006) Transforming
Growth Factor-β1 Modulates Extracellular Matrix Production, Proliferation, and Apoptosis of Endothelial
Progenitor Cells in Tissue-Engineering Scaffolds. Circulation, 114, 1193-1199.
Murine Liver Tissue
Sato,Y., Harada,K., Furubo,S., Kizawa,K., Sanzen,T., Yasoshima,M., Ozaki,S., Isse,K., Sasaki,M. and Nakanuma,Y.
(2006) Inhibition of Intrahepatic Bile Duct Dilation of the Polycystic Kidney Rat with a Novel Tyrosine Kinase
Inhibitor Gefitinib. American Journal of Pathology, 169, 1238.
Porcine Cardiac Valve Leaflets
Schenke-Layland, K., Madershahian, N., Riemann, I., Starcher, B., Halbhuber, K. J., Konig, K., and Stock, U. A.
Impact of Cryopreservation on Extracellular Matrix Structures of Heart Valve Leaflets. The Annals of
Thoracic Surgery 81, 918-926.
Human Primary Fibroblast Cultures from Scleroderma Patients
Sherriff-Tadano,R., Ohta,A., Morito,F., Mitamura,M., Haruta,Y., Koarada,S., Tada,Y., Nagasawa,K. and Ozaki,I.
(2006) Antifibrotic effects of hepatocyte growth factor on scleroderma fibroblasts and analysis of its
mechanism. Modern Rheumatology, 16, 364-371.
Murine Lung Tissue
Shim,Y.M., Zhu,Z., Zheng,T., Lee,C.G., Homer,R.J., Ma,B. and Elias,J.A. (2006) Role of 5-Lipoxygenase in IL-13Induced Pulmonary Inflammation and Remodeling. The Journal of Immunology, 177, 1918.
Porcine Heart Valves
Stock,U.A., Degenkolbe,I., Attmann,T., Schenke-Layland,K., Freitag,S. and Lutter,G. (2006) Prevention of devicerelated tissue damage during percutaneous deployment of tissue-engineered heart valves. The Journal of
Thoracic and Cardiovascular Surgery, 131, 1323-1330.
Murine Lung Tissue and Bronchoalveolar Lavage Fluid
Sun,C.X., Zhong,H., Mohsenin,A., Morschl,E., Chunn,J.L., Molina,J.G., Belardinelli,L., Zeng,D. and Blackburn,M.R.
(2006) Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and
injury. Journal of Clinical Investigation, 116, 2173-2182.
Human Tendon Fibroblasts
Talwalkar,S.C., Evans,C.E., Trail,I.A. and McGrouther,D.A. (2006) Does Anatomical Location of a Tendon (Hand or
Forearm) Influences Fibroblast Function in the Presence of Physical Forces. Journal of Bone and Joint
Surgery – British Volume 88-B Supp. III:411.
Volmer,J.B., Thompson,L.F. and Blackburn,M.R. (2006) Ecto-5'-Nucleotidase (CD73)-Mediated Adenosine Production
Is Tissue Protective in a Model of Bleomycin-Induced Lung Injury. The Journal of Immunology, 176, 44494458.
Murine Liver Tissue
Wang,C.H., Lee,T.H., Lu,C.N., Chou,W.Y., Hung,K.S., Concejero,A.M. and Jawan,B. (2006) Electroporative alphaMSH gene transfer attenuates thioacetamide-induced murine hepatic fibrosis by MMP and TIMP modulation.
Gene Therapy, 13, 1000-1009.
Bovine Annulus Fibrosus Primary Cell Culture
Wilda,H. and Gough,J.E. (2006) In vitro studies of annulus fibrosus disc cell attachment, differentiation and matrix
production on PDLLA/45S5 Bioglass composite films. Biomaterials, 27, 5220-5229.
Wu,G.L.D.M. and Varga,J. (2006) Increased Bleomycin-Induced Skin Fibrosis in Mice Lacking the Th1-Specific
Transcription Factor T-bet. Pathobiology, 73, 224-237.
Yasuoka,H., Jukic,D.M., Zhou,Z., Choi,A.M. and Feghali-Bostwick,C.A. (2006) Insulin-like growth factor binding
protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis. Arthritis Rheum, 54, 3001-3010.
2005
Murine Lung Explant
Aono,Y., Nishioka,Y., Inayama,M., Ugai,M., Kishi,J., Uehara,H., Izumi,K. and Sone,S. (2005) Imatinib as a Novel
Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice. American Journal of Respiratory and
Critical Care Medicine, 171, 1279.
Murine Lung Explants
Azuma,A., Li,Y.J., Abe,S., Usuki,J., Matsuda,K., Henmi,S., Miyauchi,Y., Ueda,K., Izawa,A. and Sone,S. (2005)
Interferon-β Inhibits Bleomycin-Induced Lung Fibrosis by Decreasing Transforming Growth Factor-β and
Thrombospondin. American Journal of Respiratory Cell and Molecular Biology, 32, 93-98.
Barbarin,V., Xing,Z., Delos,M., Lison,D. and Huaux,F. (2005) Pulmonary overexpression of IL-10 augments lung
fibrosis and Th2 responses induced by silica particles. American Journal of Physiology- Lung Cellular and
Molecular Physiology, 288, 841-848.
Beamer,C.A. and Holian,A. (2005) Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis
following silica exposure. American Journal of Physiology- Lung Cellular and Molecular Physiology, 289,
186-195.
Burdick,M.D., Murray,L.A., Keane,M.P., Xue,Y.Y., Zisman,D.A., Belperio,J.A. and Strieter,R.M. (2005) CXCL11
Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling. American Journal
of Respiratory and Critical Care Medicine, 171, 261.
Human Fibroblasts
Cabral,W.A., Makareeva,E., Colige,A., Letocha,A.D., Ty,J.M., Yeowell,H.N., Pals,G., Leikin,S. and Marini,J.C.
(2005) Mutations Near Amino End of alpha 1(I) Collagen Cause Combined Osteogenesis Imperfecta/EhlersDanlos Syndrome by Interference with N-propeptide Processing. Journal of Biological Chemistry, 280,
19259-19269.
Human to Mouse Cardiac Allografts
Campbell,L.G., Ramachandran,S., Liu,W., Shipley,J.M., Itohara,S., Rogers,J.G., Moazami,N., Senior,R.M. and
Jaramillo,A. (2005) Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the
pathogenesis of cardiac allograft rejection. Am J Transplant, 5, 517-528.
Chan,C.P., Lan,W.H., Chang,M.C., Chen,Y.J., Lan,W.C., Chang,H.H. and Jeng,J.H. (2005) Effects of TGF-βs on the
growth, collagen synthesis and collagen lattice contraction of human dental pulp fibroblasts in vitro.
Archives of Oral Biology, 50, 469-479.
Chen,Q., Rabach,L., Noble,P., Zheng,T., Lee,C.G., Homer,R.J. and Elias,J.A. (2005) IL-11 Receptor a in the
Pathogenesis of IL-13-Induced Inflammation and Remodeling 1. The Journal of Immunology, 174, 23052313.
Human Periodontal Fibroblasts
Chen,Y.J., Jeng,J.H., Jane Yao,C.C., Chen,M.H., Hou,L.T. and Lan,W.H. (2005) Long-term effect of pulsed Nd: YAG
laser irradiation on cultured human periodontal fibroblasts. Lasers in Surgery and Medicine, 36, 225-233.
Choi,E.M. (2005) The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells.
Biochem Pharmacol, 70, 363-368.
Chunn,J.L., Molina,J.G., Mi,T., Xia,Y., Kellems,R.E. and Blackburn,M.R. (2005) Adenosine-Dependent Pulmonary
Fibrosis in Adenosine Deaminase-Deficient Mice 1. The Journal of Immunology, 175, 1937-1946.
Comporti,M., Arezzini,B., Signorini,C., Sgherri,C., Monaco,B. and Gardi,C. (2005) F 2-isoprostanes stimulate collagen
synthesis in activated hepatic stellate cells: a link with liver fibrosis?’ Laboratory Investigation, 85, 13811391.
Equine Tendons
Dahlgren,L., Mohammed,H. and Nixon,A. (2005) Temporal expression of growth factors and matrix molecules in
healing tendon lesions. Journal of Orthopaedic Research, 23, 84-92.
Murine Thrombi
Deatrick,K.B., Eliason,J.L., Lynch,E.M., Moore,A.J., Dewyer,N.A., Varma,M.R., Pearce,C.G., Upchurch,G.R.,
Wakefield,T.W. and Henke,P.K. (2005) Vein wall remodeling after deep vein thrombosis involves matrix
metalloproteinases and late fibrosis in a mouse model. J Vasc Surg, 42, 140-148.
Murine Abdominal Wall Samples
DuBay,D.A., Wang,X., Adamson,B., Kuzon,W.M., Dennis,R.G. and FRANZ,M.G. (2005) Progressive fascial wound
failure impairs subsequent abdominal wall repairs: A new animal model of incisional hernia formation.
Surgery, 137, 463-471.
Simian Renal Fibroblasts (NRK-49F)
El Chaar,M., Attia,E., Chen,J., Hannafin,J., Poppas,D.P. and Felsen,D. (2005) Cyclooxygenase-2 Inhibitor Decreases
Extracellular Matrix Synthesis in Stretched Renal Fibroblasts. Nephron Exp Nephrol, 100, 150-155.
Ovine Vascular Smooth Muscle Cells
Engelmayr,G.C., Mayer,J.E., Rabkin,E., Sacks,M.S., Schoen,F.J. and Sutherland,F.W.H. (2005) The independent role
of cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials, 26,
175-187.
Murine Colon Homogenate
Fichtner-Feigl,S., Fuss,I.J., Preiss,J.C., Strober,W. and Kitani,A. (2005) Treatment of murine Th1-and Th2-mediated
inflammatory bowel disease with NF-κB decoy oligonucleotides. Journal of Clinical Investigation, 115,
3057-3071.
Ovine Mesenchymal Progenitor Cells and Fetal Chondrocytes
Fuchs, J. R., Hannouche, D., Terada, S., Zand, S., Vacanti, J. P., and Fauza, D. O. (2005) Cartilage Engineering
from Ovine Umbilical Cord Blood Mesenchymal Progenitor Cells. Stem Cells 23, 958-964.
Murine Fibroblasts and Mesenchymal Stem Cells
Ge,Z., Goh,J.C.H. and Lee,E.H. (2005) Selection of Cell Source for Ligament Tissue Engineering. Cell
Transplantation, 14, 573-583.
Murine Lung Biopsies
Genovese,T., Cuzzocrea,S., Di Paola,R., Failla,M., Mazzon,E., Sortino,M.A., Frasca,G., Gili,E., Crimi,N. and
Caputi,A.P. (2005) Inhibition or knock out of inducible nitric oxide synthase result in resistance to
bleomycin-induced lung injury. Respir Res, 6, 58.
Porcine Anterior Cruciate Ligaments
Harrison,R.D. (2005) Effect of Extraction Protocols and Epidermal Growth Factor on the Cellular Repopulaton of
Decellularized Anterior Cruciate Ligament Allografts. Biomed Mater Res A,75, 841-854.
Murine Hepatic Stellate cells (HSC-T6) and Liver Samples
Hsu,Y.C., Lin,Y.L., Chiu,Y.T., Shiao,M.S., Lee,C.Y. and Huang,Y.T. (2005) Antifibrotic effects of Salvia miltiorrhiza
on dimethylnitrosamine-intoxicated rats. Journal of Biomedical Science, 12, 185-195.
Rat Left Ventricle
Iwata,K., Sawa,Y., Kitagawa-Sakakida,S., Kawaguchi,N., Matsuura,N., Nakamura,T. and Matsuda,H. (2005) Gene
transfection of hepatocyte growth factor attenuates the progression of cardiac remodeling in the
hypertrophied heart. The Journal of Thoracic and Cardiovascular Surgery, 130, 719-725.
Kato,T., Okahashi,N., Kawai,S., Kato,T., Inaba,H., Morisaki,I. and Amano,A. (2005) Impaired Degradation of Matrix
Collagen in Human Gingival Fibroblasts by the Antiepileptic Drug Phenytoin. J Periodontol, 76, 941-950.
Human Periodontal Ligament Cell Cultures
Kawase,T., Okuda,K., Saito,Y. and Yoshie,H. (2005) In vitro evidence that the biological effects of platelet-rich
plasma on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-beta
or platelet-derived growth factor. J Periodontol, 76, 760-767.
Cadaveric Human Lumbar Intervertebral Discs
Keshari,K.R., Lotz,J.C., Kurhanewicz,J. and Majumdar,S. (2005) Correlation of HR-MAS Spectroscopy Derived
Metabolite Concentrations With Collagen and Proteoglycan Levels and Thompson Grade in the Degenerative
Disc. Spine, 30, 2683-2688.
Human Myocardial Samples
Klotz, S., Foronjy, R. F., Dickstein, M. L., Gu, A., Garrelds, I. M., Jan Danser, A. H., Oz, M. C., D'Armiento, J., and
Burkhoff, D. (2005) Mechanical Unloading During Left Ventricular Assist Device Support Increases Left
Ventricular Collagen Cross-Linking and Myocardial Stiffness. Circulation 112, 364-374.
Porcine Aortic Valves in Culture
Konduri,S., Xing,Y., Warnock,J.N., He,Z. and Yoganathan,A.P. (2005) Normal Physiological Conditions Maintain the
Biological Characteristics of Porcine Aortic Heart Valves: An Ex Vivo Organ Culture Study. Annals of
Biomedical Engineering, 33, 1158-1166.
Kushibiki,T., Nagata-Nakajima,N., Sugai,M., Shimizu,A. and Tabata,Y. (2005) Delivery of plasmid DNA expressing
small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal
fibrosis. J Control Release, 105, 318-331.
Murine Dermal Fibroblasts
Lateef,H., Aslam,M.N., Stevens,M.J. and Varani,J. (2005) Pretreatment of diabetic rats with lipoic acid improves
healing of subsequently-induced abrasion wounds. Archives of Dermatological Research, 297, 75-83.
Murine Granulomas
Layland,L.E., Wagner,H. and Prazeres da Costa,C. (2005) Lack of antigen-specific Th1 response alters granuloma
formation and composition in Schistosoma mansoni-infected MyD88-/-mice. Eur.J.Immunol, 35, 3248-3257.
Human Ligament Fibroblasts
Lee,C.H., Shin,H.J., Cho,I.H., Kang,Y.M., Kim,I.A., Park,K.D. and Shin,J.W. (2005) Nanofiber alignment and
direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials, 26, 12611270.
Lee,K.H. and Choi,E.M. (2005) Biochanin A Stimulates Osteoblastic Differentiation and Inhibits Hydrogen PeroxideInduced Production of Inflammatory Mediators in MC3T3-E1 Cells. Biological & Pharmaceutical Bulletin, 28,
1948-1953.
Murine Lung Tissue Supernatant
Liu,H., Drew,P., Gaugler,A.C., Cheng,Y. and Visner,G.A. (2005) Pirfenidone inhibits lung allograft fibrosis through Larginine-arginase pathway. Am J Transplant, 5, 1256-1263.
Matsushita,M., Yamamoto,T. and Nishioka,K. (2005) Plasminogen activator inhibitor-1 is elevated, but not essential,
in the development of bleomycin-induced murine scleroderma. Clinical and Experimental Immunology,
139, 429-438.
Human Venous Myofibroblasts
Mol,A., van Lieshout,M.I., Dam-de Veen,C.G., Neuenschwander,S., Hoerstrup,S.P., Baaijens,F.P. and Bouten,C.V.C.
(2005) Fibrin as a cell carrier in cardiovascular tissue engineering applications. Biomaterials, 26, 31133121.
Moore,B.B., Ballinger,M.N., White,E.S., Green,M.E., Herrygers,A.B., Wilke,C.A., Toews,G.B. and Peters-Golden,M.
(2005) Bleomycin-Induced E Prostanoid Receptor Changes Alter Fibroblast Responses to Prostaglandin E2 1.
The Journal of Immunology, 174, 5644-5649.
Cricetine Left Ventricles
Nakamura,T., Matsumoto,K., Mizuno,S., Sawa,Y., Matsuda,H. and Nakamura,T. (2005) Hepatocyte growth factor
prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts. American Journal
of Physiology- Heart and Circulatory Physiology, 288, 2131-2139.
Human Lung Fibroblast Culture Supernatants
Nakoman,C., Resmi,H., Ay,O., Acikel,U., Atabey,N. and Güner,G. (2005) Effects of basic fibroblast factor (bFGF) on
MMP-2, TIMP-2, and type-I collagen levels in human lung carcinoma fibroblasts. Biochimie, 87, 343-351.
Leporine Temporomandibular Joint Discs
Naqvi,T., Duong,T.T., Hashem,G., Shiga,M., Zhang,Q. and Kapila,S. (2005) Relaxin's induction of metalloproteinases
is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants.
Arthritis Res Ther, 7, R1-11.
Nethery,D.E., Moore,B.B., Minowada,G., Carroll,J., Faress,J.A. and Kern,J.A. (2005) Expression of mutant human
epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. Journal of Applied Physiology,
99, 298-307.
Human Atheromatous Plaques
Penz, S., Reininger, A. J., Brandl, R., Goyal, P., Rabie, T., Bernlochner, I., Rother, E., Goetz, C., Engelmann, B.,
and Smethurst, P. A. (2005) Human atheromatous plaques stimulate thrombus formation by activating
platelet glycoprotein VI. The FASEB Journal 19, 898-909. 2005.
Porcine Chordae Tendineae
Ritchie, J., Warnock, J. N., and Yoganathan, A. P. (2005) Structural Characterization of the Chordae Tendineae in
Native Porcine Mitral Valves. The Annals of Thoracic Surgery 80, 189-197.
Murine Osteoblast Primary Cultures
Sampaio,B.V., Göller,G., Oktar,F.N., Val rio,P., Goes,A.M. and Leite,M.F. (2005) Biocompatibility Evaluation of
Three Different Titanium-Hydroxyapatite Composites. Key Eng.Mater, 284, 639-642.
Santiago,B., Gutierrez-Cañas,I., Dotor,J., Palao,G., Lasarte,J.J., Ruiz,J., Prieto,J., Borrbs-Cuesta,F., Pablos,J.L.
and Biotech,D. (2005) Topical Application of a Peptide Inhibitor of Transforming Growth Factor-bold beta 1
Ameliorates Bleomycin-Induced Skin Fibrosis. Journal of Investigative Dermatology, 125, 450-455.
Murine Osteoblast Primary Cultures
Schainberg,APM., Özyeğin,LS., Kursuoğlu,P., Valério,P., Goes,AM. and Leite,MF. (2005) Biocompatibility evaluation
of Zeolite compared to bone HA, calcium phosphate (Ca2PO4) and Eugenol Paste. Key Engineering Materials
284-286, 561-564.
Murine Lung Tissue
Strieter,R.M., Keane,M.P., Burdick,M.D., Sakkour,A., Murray,L.A. and Belperio,J.A. (2005) The role of CXCR2/CXCR2
ligands in acute lung injury. Curr.Drug Targets Inflamm.Allergy, 4, 299-303.
Human Hepatic Stellate LI90 Cell Line
Sugimoto,R., Enjoji,M., Nakamuta,M., Ohta,S., Kohjima,M., Fukushima,M., Kuniyoshi,M., Arimura,E., Morizono,S.
and Kotoh,K. (2005) Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate
cells. Liver International, 25, 420-428.
Ovine Fetal and Adult Chondrocytes
Terada,S., Fuchs,J.R., Yoshimoto,H., Fauza,D.O. and Vacanti,J.P. (2005) In Vitro Cartilage Regeneration From
Proliferated Adult Elastic Chondrocytes. Annals of Plastic Surgery, 55, 196-201.
Ovine Chondrocytes
Terada,S., Yoshimoto,H., Fuchs,J.R., Sato,M., Pomerantseva,I., Selig,M.K., Hannouche,D. and Vacanti,J.P. (2005)
Hydrogel optimization for cultured elastic chondrocytes seeded onto a polyglycolic acid scaffold.
J.Biomed.Mater.Res.75A, 907-916.
Murine Osteoblast Primary Culture
Valério,P., Guimarbes,M.H.R., Pereira,M.M., Leite,M.F. and Goes,A.M. (2005) Primary osteoblast cell response to
sol-gel derived bioactive glass foams. Journal of Materials Science: Materials in Medicine, 16, 851-856.
Human Fibroblast Primary Culture
Vancheri,C., Gili,E., Failla,M., Mastruzzo,C., Salinaro,E.T., LoFurno,D., Pistorio,M.P., La Rosa,C., Caruso,M. and
Crimi,N. (2005) Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2
receptor. The Journal of Allergy and Clinical Immunology, 116, 1242-1248.
Vittal, R., Horowitz, J. C., Moore, B. B., Zhang, H., Martinez, F. J., Toews, G. B., Standiford, T. J., and Thannickal,
V. J. (2005) Modulation of Prosurvival Signaling in Fibroblasts by a Protein Kinase Inhibitor Protects against
Fibrotic Tissue Injury. American Journal of Pathology 166, 367-375.
Canine Arterial Tissue
Yamaguchi-Okada,M., Nishizawa,S., Koide,M. and Nonaka,Y. (2005) Biomechanical and phenotypic changes in the
vasospastic canine basilar artery after subarachnoid hemorrhage. Journal of Applied Physiology, 99, 20452052.
Murine Pancreatic Tissue
Yoo,B.M., Yeo,M., Oh,T.Y., Choi,J.H., Kim,W.W., Kim,J.H., Cho,S.W., Kim,S.J. and Hahm,K.B. (2005) Amelioration
of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas, 30, e71-e79.
Murine Pancreatic Tissue
Yoo,B.M., Oh,T.Y., Kim,Y.B., Yeo,M., Lee,J.S., Surh,Y.J., Ahn,B.O., Kim,W.H., Sohn,S. and Kim,J.H. (2005) Novel
Antioxidant Ameliorates the Fibrosis and Inflammation of Cerulein-Induced Chronic Pancreatitis in a Mouse
Model. Pancreatology, 5, 165-176.
Zhou,Y-j., Yin,D-m., Chen,H-s., Shi,J-h., Sha,B-x. and Wang,X. (2005) Inhibitory effects of idoxifene on hepatic
fibrosis in rats. Acta Pharmacologia Sinica, 26, 581-586.
2004
Barbarin, V., Arras, M., Misson, P., Delos, M., McGarry, B., Phan, S. H., Lison, D., and Huaux, F. (2004)
Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice. American Journal of
Respiratory Cell and Molecular Biology 31, 78-85. 299.
Belperio,J.A., Dy,M., Murray,L., Burdick,M.D., Xue,Y.Y., Strieter,R.M. and Keane,M.P. (2004) The Role of the Th2
CC Chemokine Ligand CCL17 in Pulmonary Fibrosis 1. The Journal of Immunology, 173, 4692-4698.
Human Lung Tissue Samples and Murine Lung Homogenates
Berman,J.S., Serlin,D., Li,X., Whitley,G., Hayes,J., Rishikof,D.C., Ricupero,D.A., Liaw,L., Goetschkes,M. and
O'Regan,A.W. (2004) Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice. American
Journal of Physiology- Lung Cellular and Molecular Physiology, 286, 1311-1318.
Murine Mammary Carcinoma MCa Cell Line
Casarsa,C., Mischis,M.T. and Sava,G. (2004) TGFbeta1 regulation and collagen-release-independent connective
tissue re-modelling by the ruthenium complex NAMI-A in solid tumours. Journal of Inorganic Biochemistry,
98, 1648-1654.
Murine Lung Samples
Cho,J. (2004) ISS inhibits expression of MMP-9 and MMP-2 in a mouse model of airway remodeling. The Journal of
Allergy and Clinical Immunology, 113, 92.
Cilli,F., Khan,M., Fu,F. and Wang,J.H. (2004) Prostaglandin E2 affects proliferation and collagen synthesis by human
patellar tendon fibroblasts. Clin J Sport Med, 14, 232-236.
Human Pediatric Aortic Cells
Fu,P., Sodian,R., Luders,C., Lemke,T., Kraemer,L., Hubler,M., Weng,Y., Hoerstrup,S.P., Meyer,R. and Hetzer,R.
(2004) Effects of basic fibroblast growth factor and transforming growth factor-beta on maturation of
human pediatric aortic cell culture for tissue engineering of cardiovascular structures. ASAIO J, 50, 9-14.
Hattori, N., Mizuno, S., Yoshida, Y., Chin, K., Mishima, M., Sisson, T. H., Simon, R. H., Nakamura, T., and Miyake,
M. (2004) The Plasminogen Activation System Reduces Fibrosis in the Lung by a Hepatocyte Growth FactorDependent Mechanism. American Journal of Pathology, 164, 1091-1098.
Murine Lung Samples
Honda,K., Marquillies,P., Capron,M. and Dombrowicz,D. (2004) Peroxisome proliferator-activated receptor γ is
expressed in airways and inhibits features of airway remodeling in a mouse asthma model. The Journal of
Allergy and Clinical Immunology, 113, 882-888.
Murine Liver Tissues
Hsu,Y.C., Chiu,Y.T., Lee,C.Y., Lin,Y.L. and Huang,Y.T. (2004) Increases in fibrosis-related gene transcripts in livers
of dimethylnitrosamine-intoxicated rats. Journal of Biomedical Science, 11, 408-417.
Murine Periodontal Ligament Cells
Inoue,M., LeGeros,R.Z., Hoffman,C., Diamond,K., Rosenberg,P.A. and Craig,R.G. (2004) Effect of enamel matrix
proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. Journal of
Biomedical Materials Research, 69, 172-179.
Murine Osteoblast-like (MC3T3-E1) and Odontoblast-like (MDPC23) Cell Lines
Inoue,M., LeGeros,R.Z., Inoue,M., Tsujigiwa,H., Nagatsuka,H., Yamamoto,T. and Nagai,N. (2004) In vitro response
of osteoblast-like and odontoblast-like cells to unsubstituted and substituted apatites. Journal of
Biomedical Materials Research, 70, 585-593.
Kolodsick,J.E., Toews,G.B., Jakubzick,C., Hogaboam,C., Moore,T.A., McKenzie,A., Wilke,C.A., Chrisman,C.J. and
Moore,B.B. (2004) Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts 1. The Journal of Immunology,
172, 4068-4076.
Murine Hepatic Stellate Cells and Liver Tissue and Human Hepatic Stellate (TWNT-4) Cell Line
Kotoh,K., Nakamuta,M., Kohjima,M., Fukushima,M., Morizono,S., Kobayashi,N., Enjoji,M. and Nawata,H. (2004)
Arg-Gly-Asp (RGD) peptide ameliorates carbon tetrachloride-induced liver fibrosis via inhibition of collagen
production and acceleration of collagenase activity. Int J Mol Med, 14, 1049-1053.
Human Fibroblast (NHDF) Cell Line
Koya-Miyata,S., Okamoto,I., Ushio,S., Iwaki,K., Ikeda,M. and Kurimoto,M. (2004) Identification of a Collagen
Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism. Bioscience,
Biotechnology, and Biochemistry, 68, 767-773.
Human Dermal Biopsy
Lateef, H., Stevens, M. J., and Varani, J. (2004) All-trans-Retinoic Acid Suppresses Matrix Metalloproteinase Activity
and Increases Collagen Synthesis in Diabetic Human Skin in Organ Culture. American Journal of Pathology
165, 167-174.
Human and Murine Bone Marrow Stromal Fibroblasts
Lawson,M.A., Barralet,J.E., Wang,L., Shelton,R.M. and Triffitt,J.T. (2004) Adhesion and Growth of Bone Marrow
Stromal Cells on Modified Alginate Hydrogels. Tissue Engineering, 10, 1480-1491.
Lee,C.G., Link,H., Baluk,P., Homer,R.J., Chapoval,S., Bhandari,V., Kang,M.J., Cohn,L., Kim,Y.K. and
McDonald,D.M. (2004) Vascular endothelial growth factor (VEGF) induces remodeling and enhances T H 2mediated sensitization and inflammation in the lung. Nature Medicine, 10, 1095-1103.
Leporine Chondrocytes
Lee,J. and Son,Y. (2004) TGF-beta Stimulates Conversion of Fibrocartilage Phenotype of Costal Chondrocytes.
Tissue Eng.Reg.Med, 1, 171-177.
Human Embryonic Kidney (HEK-293, 293-EBNA and 293-T) Cell Lines and Human Fibrosarcoma (HT1080) Cell Line
Leitinger,B., Steplewski,A. and Fertala,A. (2004) The D2 period of collagen II contains a specific binding site for the
human discoidin domain receptor, DDR2. J Mol Biol, 344, 993-1003.
Human Cardiac Left Ventricle Tissue
Liang,H., Müller,J., Weng,Y.G., Wallukat,G., Fu,P., Lin,HS, Bartel,S., Knosalla,C., Pregla,R. and
Hetzer,R.(2004) Changes in myocardial collagen content before and after left ventricular assist device
application in dilated cardiomyopathy. Chinese Medical Journal, 117, 401-407.
Mcmillan,S.J. and Lloyd,C.M. (2004) Prolonged allergen challenge in mice leads to persistent airway remodelling.
Clinical & Experimental Allergy, 34, 497-507.
Human Colonic Tissue
Mimura,T., Bateman,A.C., Lee,R.L., Johnson,P.A., McDonald,P.J., Talbot,I.C., Kamm,M.A., MacDonald,T.T. and
Pender,S.L.F. (2004) Up-Regulation of Collagen and Tissue Inhibitors of Matrix Metalloproteinase in Colonic
Diverticular Disease. Diseases of the Colon & Rectum, 47, 371-379.
Nomura,Y., Taniguchi,M., Miyata,M., Ariyasu,T., Yamauchi,H., Ikeda,M. and Kurimoto,M. (2004) Interferon-gamma
liniment protects hairless mice against ultraviolet irradiation-induced skin damage. Biomedical Research,
25, 277-285.
Murine Lung Tissue
Ono, M., Sawa, Y., Mizuno, S., Fukushima, N., Ichikawa, H., Bessho, K., Nakamura, T., and Matsuda, H. (2004)
Hepatocyte Growth Factor Suppresses Vascular Medial Hyperplasia and Matrix Accumulation in Advanced
Pulmonary Hypertension of Rats. Circulation, 110, 2896-2902.
Murine Gingival Fibroblasts
Paik,J.W., Kim,C.S., Cho,K.S., Chai,J.K., Kim,C.K. and Choi,S.H. (2004) Inhibition of cyclosporin A-induced gingival
overgrowth by azithromycin through phagocytosis: an in vivo and in vitro study. J Periodontol, 75, 380-387.
Murine Lung Tissue
Phillips,R.J., Burdick,M.D., Hong,K., Lutz,M.A., Murray,L.A., Xue,Y.Y., Belperio,J.A., Keane,M.P. and Strieter,R.M.
(2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. Journal of
Clinical Investigation, 114, 438-446.
Leporine Bronchoalveolar Lavage Fluid
Schmidt,R., Ruppert,C., Markart,P., Lubke,N., Ermert,L., Weissmann,N., Breithecker,A., Ermert,M., Seeger,W. and
Gunther,A. (2004) Changes in pulmonary surfactant function and composition in bleomycin-induced
pneumonitis and fibrosis. Toxicology and Applied Pharmacology, 195, 218-231.
Ovine, Leporine and Murine Tissue Constructs
Shieh,S.J. and Terada,S. (2004) Tissue engineering auricular reconstruction: in vitro and in vivo studies.
Biomaterials, 25, 1545-1557.
Bovine Collagen
Skilbeck,C.A., Walker,P.G., David,T. and Nash,G.B. (2004) Disturbed flow promotes deposition of leucocytes from
flowing whole blood in a model of a damaged vessel wall. British Journal of Haematology, 126, 418-427.
Human Fibrosarcoma (HT-1080) Cell Line Procollagen
Steplewski,A., Ito,H., Rucker,E., Brittingham,R.J., Alabyeva,T., Gandhi,M., Ko,F.K., Birk,D.E., Jimenez,S.A. and
Fertala,A. (2004) Position of single amino acid substitutions in the collagen triple helix determines their
effect on structure of collagen fibrils. J Struct Biol, 148, 326-337.
Sue,R.D., Belperio,J.A., Burdick,M.D., Murray,L.A., Xue,Y.Y., Dy,M.C., Kwon,J.J., Keane,M.P. and Strieter,R.M.
(2004) CXCR2 Is Critical to Hyperoxia-Induced Lung Injury 1. The Journal of Immunology, 172, 3860-3868.
Human Lymphoblast-like Jurkat D1.1 and E6-1 Cell Lines and Human Primary Fibroblast Lines
Suppl,A., Yurovsky,V.V. and White,B. (2004) Effect of CD154-CD40 interactions on collagen production by
fibroblasts. Arthritis Res. 3A, P062.
Suzuki,M., Tanabe,F., Nakamura,S., Motoda,R. and Orita,K. (2004) NK-355, an aminovinyl photosensitizing dye,
enhances collagen production through TGF-β1 upregulation. Journal of Dermatological Science, 34, 56-58.
Murine Brain Tissue
Tang,J., Liu,J., Zhou,C., Alexander,J.S., Nanda,A., Granger,D.N. and Zhang,J.H. (2004) MMP-9 Deficiency Enhances
Collagenase-Induced Intracerebral Hemorrhage and Brain Injury in Mutant Mice. Journal of Cerebral Blood
Flow & Metabolism, 24, 1133-1145.
Valerio,P., Pereira,M.M., Goes,A.M. and Leite,M.F. (2004) The effect of ionic products from bioactive glass
dissolution on osteoblast proliferation and collagen production. Biomaterials, 25, 2941-2948.
Murine Thrombi
Varma,M.R., Moaveni,D.M., Dewyer,N.A., Varga,A.J., Deatrick,K.B., Kunkel,S.L., Upchurch Jr,G.R., Wakefield,T.W.
and Henke,P.K. (2004) Deep vein thrombosis resolution is not accelerated with increased
neovascularization. J Vasc Surg, 40, 536-542.
Murine Primary Hepatic Stellate Cell Line
Wada,W., Kuwano,H., Hasegawa,Y. and Kojima,I. (2004) The Dependence of Transforming Growth Factor-β-Induced
Collagen Production on Autocrine Factor Activin A in Hepatic Stellate Cells. Endocrinology, 145, 2753-2759.
Watanabe,S., Nagashio,Y., Asaumi,H., Nomiyama,Y., Taguchi,M., Tashiro,M., Kihara,Y., Nakamura,H. and Otsuki,M.
(2004) Pressure activates rat pancreatic stellate cells. American Journal of Physiology- Gastrointestinal and
Liver Physiology, 287, 1175-1181.
Yamamoto,T. and Nishioka,K. (2004) Animal model of sclerotic skin. VI: Evaluation of bleomycin-induced skin
sclerosis in nude mice. Archives of Dermatological Research, 295, 453-456.
Yamamoto,T. and Nishioka,K. (2004) Possible Role of Apoptosis in the Pathogenesis of Bleomycin-Induced
Scleroderma. Journal of Investigative Dermatology, 122, 44-50.
Human Left Ventricle Tissue Biopsies
Zhang,J. and Narula,J. (2004) Molecular biology of myocardial recovery. Surg Clin North Am, 84, 223-242.
Human Pulmonary Fibroblasts
Zhang,L., Keane,M.P., Zhu,L.X., Sharma,S., Rozengurt,E., Strieter,R.M., Dubinett,S.M. and Huang,M. (2004)
Interleukin-7 and Transforming Growth Factor-{beta} Play Counter-regulatory Roles in Protein Kinase C{delta}-dependent Control of Fibroblast Collagen Synthesis in Pulmonary Fibrosis. Journal of Biological
Chemistry, 279, 28315-28319.
2003
Blackburn,M.R., Lee,C.G., Young,H.W.J., Zhu,Z., Chunn,J.L., Kang,M.J., Banerjee,S.K. and Elias,J.A. (2003)
Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13adenosine amplification pathway. Journal of Clinical Investigation, 112, 332-344.
Trout Plasma, Endolymph and Otolith Explant
Borelli,G., Guibbolini,M.E., Mayer-Gostan,N., Priouzeau,F., De Pontual,H., Allemand,D., Puverel,S., Tambutte,E.
and Payan,P. (2003) Daily variations of endolymph composition: relationship with the otolith calcification
process in trout. Journal of Experimental Biology, 206, 2685-2692.
Human Fibroblasts
Cabral,W.A., Mertts,M.V., Makareeva,E., Colige,A., Tekin,M., Pandya,A., Leikin,S. and Marini,J.C. (2003) Type I
Collagen Triplet Duplication Mutation in Lethal Osteogenesis Imperfecta Shifts Register of a Chains
throughout the Helix and Disrupts Incorporation of Mutant Helices into Fibrils and Extracellular Matrix.
Journal of Biological Chemistry, 278, 10006-10012.
Murine Lung Samples
Chung,MP., Monick,MM., Hamzeh,NY., Butler,NS., Powers,LS. and Hunninghake,GW. (2003) Role of repeated lung
injury and genetic background in bleomycin-induced fibrosis. American Journal of Respiratory Cell and
Molecular Biology 29, 375-380.
Denton,C.P., Zheng,B., Evans,L.A., Shi-wen,X., Ong,V.H., Fisher,I., Lazaridis,K., Abraham,D.J., Black,C.M. and de
Crombrugghe,B. (2003) Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth
Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in
Transgenic Mice. Journal of Biological Chemistry, 278, 25109-25119.
Human Atherosclerotic Plaques
Goncalves, I., Moses, J., Dias, N., Pedro, L. M., Fernandes e Fernandes, Nilsson, J., and Ares, M. P. S. (2003)
Changes Related to Age and Cerebrovascular Symptoms in the Extracellular Matrix of Human Carotid
Plaques. Stroke 34, 616-622.
Huaux,F., Liu,T., McGarry,B., Ullenbruch,M., Xing,Z. and Phan,S.H. (2003) Eosinophils and T Lymphocytes Possess
Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis 1. The Journal of Immunology, 171, 54705481.
Murine Fibroblasts
Huaux,F., Liu,T., McGarry,B., Ullenbruch,M. and Phan,S.H. (2003) Dual Roles of IL-4 in Lung Injury and Fibrosis 1.
The Journal of Immunology, 170, 2083-2092.
Murine Lung Hydrolysates
Hutson,P.R., Crawford,M.E. and Sorkness,R.L. (2003) Liquid chromatographic determination of hydroxyproline in
tissue samples. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences,
791, 427-430.
Leporine Chondrocytes
Ibusuki,S., Fujii,Y., Iwamoto,Y. and Matsuda,T. (2003) Tissue-Engineered Cartilage Using an Injectable and in Situ
Gelable Thermoresponsive Gelatin: Fabrication and in Vitro Performance. Tissue Engineering, 9, 371-384.
Murine Osteoblast-like MC3T3-E1 Cell Line
Luppen,C.A., Smith,E., Spevak,L., Boskey,A.L. and Frenkel,B. (2003) Bone morphogenetic protein-2 restores
mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures. J Bone Miner Res, 18,1186-1197.
Murine Osteoblast-like MC3T3-E1 Subclone Cell Line
Luppen,C.A., Leclerc,N., Noh,T., Barski,A., Khokhar,A., Boskey,A.L., Smith,E. and Frenkel,B. (2003) Brief Bone
Morphogenetic Protein 2 Treatment of Glucocorticoid-inhibited MC3T3-E1 Osteoblasts Rescues Commitmentassociated Cell Cycle and Mineralization without Alteration of Runx2. Journal of Biological Chemistry, 278,
44995-45003.
Ohnishi, N., Miyata, T., Ohnishi, H., Yasuda, H., Tamada, K., Ueda, N., Mashima, H., and Sugano, K. (2003) Activin
A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for
pancreatic fibrosis. Gut 52, 1487-1493.
Porcine, Ovine and Tissue-Engineered Cardiac Valve Leaflets
Schenke-Layland,K., Opitz,F., Gross,M., Döring,C., Halbhuber,K.J., Schirrmeister,F., Wahlers,T. and Stock,U.A.
(2003) Complete dynamic repopulation of decellularized heart valves by application of defined physical
signals - an in vitro study. Cardiovascular Research, 60, 497-509.
Suzuki, H., Aoshiba, K., Yokohori, N., and Nagai, A. (2003) Epidermal Growth Factor Receptor Tyrosine Kinase
Inhibition Augments a Murine Model of Pulmonary Fibrosis 1. Cancer Research 63, 5054-5059.
Murine Thrombi
Thanaporn,P., Myers,D.D., Wrobleski,S.K., Hawley,A.E., Farris,D.M., Wakefield,T.W. and Henke,P.K. (2003) Pselectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model. Surgery, 134, 365-371.
Valério,P., Goes,A.M., Pereira,M.M. and Leite,M.F. (2003) Cytological and biochemical evaluation of osteoblast in
contact with ionic products of bioactive ceramics. Key Engineering Materials, 240, 703-706.
Murine Plasma
Vergnes,L., Phan,J., Strauss,M., Tafuri,S. and Reue,K. (2003) Cholesterol and Cholate Components of an
Atherogenic Diet Induce Distinct Stages of Hepatic Inflammatory Gene Expression. Journal of Biological
Chemistry, 278, 42774-42784.
Yamamoto,T. and Nishioka,K. (2003) Role of Monocyte Chemoattractant Protein-1 and its Receptor, CCR-2, in the
Pathogenesis of Bleomycin-Induced Scleroderma. Journal of Investigative Dermatology, 121, 510-516.
Human Lung Fibroblast (8F1024, 8F1608 and 9F0892) Cell Lines
Yurovsky,VV. (2003) Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Enhances Collagen Production by
Human Lung Fibroblasts. American Journal of Respiratory Cell and Molecular Biology, 28, 225-231.
2002
Blease, K., Schuh, J. M., Jakubzick, C., Lukacs, N. W., Kunkel, S. L., Joshi, B. H., Puri, R. K., Kaplan, M. H., and
Hogaboam, C. M. (2002) Stat6-Deficient Mice Develop Airway Hyperresponsiveness and Peribronchial Fibrosis
during Chronic Fungal Asthma. American Journal of Pathology 160(2), 481-490.
Human Pulmonary Fibrosis Fibroblasts, Normal Fibroblasts, U4A, U3A, and U4A/JAK1 Cell Lines and
Murine Lung Samples
Huang,M., Sharma,S., Zhu,L.X., Keane,M.P., Luo,J., Zhang,L., Burdick,M.D., Lin,Y.Q., Dohadwala,M. and
Gardner,B. (2002) IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis. Journal of
Clinical Investigation, 109, 931-937.
Jain,V.V., Kitagaki,K., Businga,T., Hussain,I., George,C., O'Shaughnessy,P. and Kline,J.N. (2002) CpGoligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. The Journal of
Allergy and Clinical Immunology, 110, 867-872.
Murine Liver Samples
Kitamura,K., Nakamoto,Y., Akiyama,M., Fujii,C., Kondo,T., Kobayashi,K., Kaneko,S. and Mukaida,N. (2002)
Pathogenic Roles of Tumor Necrosis Factor Receptor p55-Mediated Signals in Dimethylnitrosamine-Induced
Murine Liver Fibrosis. Lab Invest, 82, 571-584.
Cultured Neonatal Heart Smooth-Muscle Cells
Langford,S.D., Trent,M.B. and Boor,P.J. (2002) Semicarbazide-sensitive amine oxidase and extracellular matrix
deposition by smooth-muscle cells. Cardiovascular Toxicology, 2, 141-150.
Lanone,S., Zheng,T., Zhu,Z., Liu,W., Lee,C.G., Ma,B., Chen,Q., Homer,R.J., Wang,J. and Rabach,L.A. (2002)
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and-12 in IL-13-induced
inflammation and remodeling. Journal of Clinical Investigation, 110, 463-474.
Murine Cardiac Samples
Li,Y.Y., Kadokami,T., Wang,P., McTiernan,C.F. and Feldman,A.M. (2002) MMP inhibition modulates TNF-a
transgenic mouse phenotype early in the development of heart failure. American Journal of PhysiologyHeart and Circulatory Physiology, 282, 983-989.
Murine Glomerular Mesangial Cells
Routh,R., McCarthy,K. and Welbourne,T. (2002) Troglitazone inhibits glutamine metabolism in rat mesangial cells.
American Journal of Physiology- Endocrinology and Metabolism, 282, 231-238.
Murine Lung Tissue
Schuh,JM., Power,CA., Proudfoot,AE., Kunkel,SL, Lukacs,NW and Hogaboam,CM. (2002) Airway
hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses
to aspergillus in CCR4-/- mice. FASEB J. 16, 1313-1315.
Murine Lung Tissue
Suhara, H., Sawa, Y., Fukushima, N., Kagisaki, K., Yokoyama, C., Tanabe, T., Ohtake, S., and Matsuda, H. (2002)
Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary
hypertension in rats. The Journal of Thoracic and Cardiovascular Surgery 123, 855-861.
Takeda,U., Utani,A., Wu,J., Adachi,E., Koseki,H., Taniguchi,M., Matsumoto,T., Ohashi,T., Sato,M. and Shinkai,H.
(2002) Targeted Disruption of Dermatopontin Causes Abnormal Collagen Fibrillogenesis. Journal of
Yamamoto,T. and Nishioka,K. (2002) Analysis of the effect of halofuginone on bleomycin-induced scleroderma.
Rheumatology, 41, 594-596.
2001
Bovine Chondrocytes
Amiel,G.E., Yoo,J.J., Kim,B.S. and Atala,A. (2001) Tissue engineered stents created from chondrocytes. J Urol,
165, 2091-2095.
Human Granulosa Cells
Aston,K.E., Stamouli,A., Thomas,E.J., Vyas,S., Iredale,J.P., Arthur,M.J.P. and Richardson,M.C. (2001)
Endocrinology and paracrinology Effect of gonadotrophin on cell and matrix retention and expression of
metalloproteinases and their inhibitor in cultured human granulosa cells modelling corpus luteum function.
Molecular Human Reproduction, 2, 26-30.
Blease,K., Jakubzick,C., Schuh,J.M., Joshi,B.H., Puri,R.K. and Hogaboam,C.M. (2001) IL-13 Fusion Cytotoxin
Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice 1. The Journal of Immunology, 167,
6583-6592.
Trout and Turbot Endolymph and Otoliths
Borelli,G., Mayer-Gostan,N., De Pontual,H., Boeuf,G. and Payan,P. (2001) Biochemical Relationships Between
Endolymph and Otolith Matrix in the Trout (Oncorhynchus mykiss) and Turbot (Psetta maxima). Calcified
Tissue International, 69, 356-364.
Bouma,P., Cabral,W.A., Cole,W.G. and Marini,J.C. (2001) COL5A1 Exon 14 Splice Acceptor Mutation Causes a
Functional Null Allele, Haploinsufficiency of a1 (V) and Abnormal Heterotypic Interstitial Fibrils in EhlersDanlos Syndrome II. Journal of Biological Chemistry, 276, 13356-13364.
Leporine Lens Epithelial Cells
Ishida,I., Saika,S. and Ohnishi,Y. (2001) Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ.
Graefe's Archive for Clinical and Experimental Ophthalmology, 239, 770-777.
Leporine Lens Epithelial Cells
Ishida,I.K.U. (2001) Experimental study on the efficacy of minoxidil in preventing postoperative capsular
opacification. Journal of the Wakayama Medical Society, 52, 207-215.
Lee,C.G., Homer,R.J., Zhu,Z., Lanone,S., Wang,X., Koteliansky,V., Shipley,J.M., Gotwals,P., Noble,P. and Chen,Q.
(2001) Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth
Factor β1. Journal of Experimental Medicine, 194, 809-822.
Human Left Ventricle Samples
Li, Y. Y., Feng, Y., McTiernan, C. F., Pei, W., Moravec, C. S., Wang, P., Rosenblum, W., Kormos, R. L., and
Feldman, A. M. (2001) Downregulation of Matrix Metalloproteinases and Reduction in Collagen Damage in
the Failing Human Heart After Support With Left Ventricular Assist Devices. Circulation 104, 1147-1152.
Murine Renal Tissue
Mizuno,S., Matsumoto,K. and Nakamura,T. (2001) Hepatocyte growth factor suppresses interstitial fibrosis in a
mouse model of obstructive nephropathy. Kidney International, 59, 1304-1314.
Rat Fetal Lung Fibroblast (RFL-6) Cell Line
Samimi,A. and Last,J.A. (2001) Inhibition of Lysyl Hydroxylase by Malathion and Malaoxon. Toxicology and Applied
2000
Rat Aortic Smooth Muscle Cells and Pig Auricular Chondrocytes
Brown, AN., Kim, BS., Alsberg,E. And Mooney,DJ.(2000) Combining Chondrocytes and Smooth Muscle Cells to
Engineer Hybrid Soft Tissue Constructs. Tissue Engineering, 6, 297-305.
Human Primary Fibroblast Cultures
Kurasawa,K., Hirose,K., Sano,H., Endo,H., Shinkai,H., Nawata,Y., Takabayashi,K. and Iwamoto,I. (2000) Increased
interleukin-17 production in patients with systemic sclerosis. Arthritis & Rheumatism, 43, 2455-2463.
Murine Cardiac Left Ventricles
Li,Y.Y., Feng,Y.Q., Kadokami,T., McTiernan,C.F., Draviam,R., Watkins,S.C. and Feldman,A.M. (2000) Myocardial
extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be
modulated by anti-tumor necrosis factor alpha therapy. Proceedings of the National Academy of Sciences,
97, 12746.
Murine Renal Tissue
Mizuno,S. (2000) Reciprocal balance of hepatocyte growth factor and transforming growth factor-β 1 in renal
fibrosis in mice. Kidney International, 57, 937.
Tokuda,A., Itakura,M., Onai,N., Kimura,H., Kuriyama,T. and Matsushima,K. (2000) Pivotal Role of CCR1-Positive
Leukocytes in Bleomycin-Induced Lung Fibrosis in Mice 1. The Journal of Immunology, 164, 2745-2751.
1999
Bovine Articular Chondrocyte Cultures
Ioannidis,N., Kurz,B., Hansen,U. and Schünke,M. (1999) Influence of fulvic acid on the collagen secretion of bovine
chondrocytes in vitro. Cell and Tissue Research, 297, 141-147.
Murine Dermis Samples
Jimenez,P.A. and Rampy,M.A. (1999) Keratinocyte Growth Factor-2 Accelerates Wound Healing in Incisional
Wounds. Journal of Surgical Research, 81, 238-242.
Murine Tail Tendon
Kuznetsova,N. and Leikin,S. (1999) Does the Triple Helical Domain of Type I Collagen Encode Molecular Recognition
and Fiber Assembly while Telopeptides Serve as Catalytic Domains? Effect of Proteolytic Cleavage On
Fibrillogenesis And On Collagen-Collagen Interaction In Fibers. Journal of Biological Chemistry, 274, 3608336088.
Murine Liver Tissue
Natsume, M. (1999) Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL6-deficient mice. Journal of Leukocyte Biology 66, 601-608.
Murine Bone Marrow Stromal Cells
Notoya,K., Nagai,H., Oda,T., Gotoh,M., Hoshino,T., Muranishi,H., Taketomi,S., Sohda,T. and Makino,H. (1999)
Enhancement of Osteogenesis In Vitro and In Vivo by a Novel Osteoblast Differentiation Promoting
Compound, TAK-778. Journal of Pharmacology and Experimental Therapeutics, 290, 1054-1064.
Murine Liver Tissue
Shimizu,I., Mizobuchi,Y., Yasuda,M., Shiba,M., Ma,Y.R., Horie,T., Liu,F. and Ito,S. (1999) Inhibitory effect of
oestradiol on activation of rat hepatic stellate cells in vivo and in vitro. Gut, 44, 127-136.
Murine Liver Tissue and Primary cultures of Stellate cells and Hepatocytes
Shimizu,I., Ma,Y.R., Mizobuchi,Y., Liu,F., Miura,T., Nakai,Y., Yasuda,M., Shiba,M., Horie,T. and Amagaya,S. (1999)
Effects of sho-saiko-to, a japanese herbal medicine, on hepatic fibrosis in rats. Hepatology, 29, 149-160.
Murine Liver Homogenate
Yasuda,M., Shimizu,I., Shiba,M. and Ito,S. (1999) Suppressive effects of estradiol on dimethylnitrosamine-induced
fibrosis of the liver in rats. Hepatology, 29, 719-727.
1998
Human Osteoblasts
Andrade,A.L., Valqrio,P., Goes,A.M., Leite,M.F. and Domingues,R.Z. (1998) Behavior of Osteoblasts Cultured on
Collagen Coated Bioactive Glass. Biomaterials, 19, 1019 – 1025.
Murine Tail Tendon
Knight,D.P., Nash,L., Hu,X.W., Haffegee,J. and Ho,M.W. (1998) In vitro formation by reverse dialysis of collagen
gels containing highly oriented arrays of fibrils. Journal of Biomedical Materials Research, 41, 185-191.
Human Bone Marrow Fibroblastic Cells
Oreffo,R.O., Driessens,F.C., Planell,J.A. and Triffitt,J.T. (1998) Effects of novel calcium phosphate cements on
human bone marrow fibroblastic cells. Tissue Eng, 4, 293-303.
Murine Aortic Explants
Tang,J., O'Callaghan,D., Rouy,S. and Godlewski,G. (1998) Quantitative changes in collagen levels following 830-nm
diode laser welding. Lasers in Surgery and Medicine, 22, 207-211.
1997
Human Amniotic Membrane Samples
Hampson,V., Liu,D., Billett,E. and Kirk,S. (1997) Amniotic membrane collagen content and type distribution in
women with preterm premature rupture of the membranes in pregnancy. BJOG: An International Journal of
Obstetrics & Gynaecology, 104, 1087-1091.
Murine Cardiac Ventricles
Lubec,B., Hjelm,M., Hoeger,H., Gialamas,J. and Lubec,G. (1997) 4-Thiaproline reduces heart lipid peroxidation and
collagen accumulation in the diabetic db/db mouse. Amino Acids, 12, 343-351.
Murine Articular Cartilage
Nakamura,M., Watanabe,J., Ogawa,R. and Kanamura,S. (1997) Immunohistochemical localization of type II and type
I collagens in articular cartilage of the femoral head of dexamethasone-treated rats. The Histochemical
Journal, 29, 645-654.
Addendum (Citations with Undetermined Experimental Model)
Asaumi,H., Watanabe,S., Taguchi,M., Nagashio,Y., Nomiyama,Y., Tashiro,M., Kihara,Y. and Otsuki,M. (2004)
Inhibition of pancreatic stellate cell activation by green tea catechin through anti-oxidative effect.
Pancreas, 29, 351.
Heemskerk,J.W., Siljander,P., Vuist,W.M., Breikers,G., Reutelingsperger,C.P., Barnes,M.J., Knight,C.G., Lassila,R.
and Farndale,R.W. (1999) Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response
of single, collagen-adherent platelets. Thromb Haemost, 81, 782-792.
Hsia-Wei Liu,P.D., Chen,C.H.W.A., Tsai,C.L.I.N., Lin,I.H. and Hsiue,G.H.O. (2007) Heterobifunctional poly(ethylene
glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cell
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