XXI World Congress on Parkinson`s Disease and Related Disorders
Transcription
XXI World Congress on Parkinson`s Disease and Related Disorders
XXI World Congress on Parkinson’s Disease and Related Disorders Milan, Italy 6-9 December 2015 PROGRAM www.oic.it/iaprd2015 XXI World Congress on Parkinson’s Disease and Related Disorders TABLE OF CONTENTS Welcome Letter ............................................................................. page 3 About IAPRD ................................................................................. page 4 Committees................................................................................... page 6 Travel Awards ............................................................................... page 8 CME Accreditation ........................................................................ page 10 Scientific Information ................................................................... page 11 Program at a glance ..................................................................... page 14 Scientific Program Sunday, 6 December .................................................................. page Monday, 7 December ................................................................. page Tuesday, 8 December ................................................................ page Wednesday, 9 December ........................................................... page 18 24 33 40 Poster Sessions Monday, 7 December ................................................................. page 45 Tuesday, 8 December ................................................................ page 56 Wednesday, 9 December ........................................................... page 69 Name Index ................................................................................... page 81 General Information ..................................................................... page 91 Social Events ................................................................................. page 94 Sponsored Symposia .................................................................... page 96 Congress Venue Layout ................................................................ page 98 Acknowledgements ...................................................................... page 101 Company Profiles .......................................................................... page 102 2 XXI World Congress on Parkinson’s Disease and Related Disorders WELCOME LETTER Dear Colleagues, on behalf of the board of the International Association of Parkinsonism and Related Disorders, it is our pleasure to welcome all of you to the XXI World Congress on Parkinson’s Disease and Related Disorders, taking place in exciting Milan, Italy. The motto of this Congress is “Sharing Richness”, and indeed, it is the ultimate goal of our Association to share the overwhelming amount of new developments in not only the understanding of the etiology and pathophysiology of the multitude of motor and behavioural disorders, but also the therapeutic strategies, essential to further increase quality of life of world-wide patients suffering those debilitating diseases. This Congress will reach this goal by bringing together a, traditionally equigender, large faculty of distinguished younger scientists, clinicians and allied health experts. The Congress includes plenary lectures, cutting edge scientific symposia, interactive forum discussions and educational workshops, and offers numerous slots for oral presentation of ongoing research and ‘selected topics.’ Milan, the undisputed international center for fashion and modern design, and cultural capital of Northern Italy, home of ‘the last supper’, offers a challenging venue to make your visit a pinnacle of your scientific tourism so far. Erik Ch. Wolters IAPRD President Angelo Antonini Congress Chair 3 XXI World Congress on Parkinson’s Disease and Related Disorders ABOUT IAPRD ABOUT THE INTERNATIONAL ASSOCIATION OF PARKINSONISM AND RELATED DISORDERS Established over fifty years ago by the World Federation of Neurology, the International Association of Parkinsonism and Related Disorders (IAPRD) is an international, professional association of clinicians, scientists and other healthcare professionals who are interested in neurodegenerative disorders including Parkinson’s disease, secondary parkinsonism, hyperkinetic and hypokinetic movement disorders, and other disorders affecting muscle tone and motor coordination. The International Association of Parkinsonism and Related Disorders is a fully independent, charitable institution under Dutch law aiming to conduct research into and advance knowledge of Parkinson’s disease and other movement disorders, as well as to advise the World Federation of Neurology in matters related to Parkinson’s disease and other movement disorders. The Association is having its registered seat in the Municipality of Amsterdam, The Netherlands, and is registered in the Trade Register of the Amsterdam Chamber of Commerce and Industries. MEETINGS The IAPRD organizes regularly meetings and educational activities, and every two years, a World Congress on Parkinson’s disease and Related Disorders is organized, which evaluates progress and identifies promising areas for research in these fields. At various intervals, also workshops on current issues in Parkinson’s disease, designed to produce consensus reports, are organized. The Committee is especially committed to developing educational programs for physicians in not fully westernized countries. 4 XXI World Congress on Parkinson’s Disease and Related Disorders ABOUT IAPRD PUBLICATIONS In order to fulfil its mission statements, IAPRD not only develops educational activities such as symposia and congresses (including the World Congress of Parkinson’s Disease and Related Disorders), but also promotes publications, among them its official journal, Parkinsonism & Related Disorders, as well as textbooks. To optimally channel communication between basic research and clinical communities, and in order to promote optimal diagnosis and treatment for the various movement disorders, Parkinsonism & Related Disorders is supplied free of charge to all IAPRD members, and listed books can be ordered by all members at reduced prices via the Amsterdam - Free University Press. To learn more about IAPRD, please visit the association website: http://www.iaprd.org/ 5 XXI World Congress on Parkinson’s Disease and Related Disorders COMMITTEES COMMITTEES Angelo Antonini, Italy (Chair) Alberto Albanese, Italy (Co-Chair) Erik Ch. Wolters, The Netherlands (President, Int. Association of Parkinsonism and Related Disorders) EXECUTIVE SCIENTIFIC BOARD Erik Ch. Wolters, The Netherlands (Chair) Alberto Albanese, Italy Angelo Antonini, Italy Christian Baumann, Switzerland Peter Riederer, Germany Moussa Youdim, Israel SCIENTIFIC PROGRAM COMMITTEE Alberto Albanese, Italy Angelo Antonini, Italy Jean-Philippe Azulay, France Christian Baumann, Switzerland Vincenzo Bonifati, The Netherlands David Brooks, United Kingdom M. Angela Cenci, Sweden Alberto J. Espay, USA Victor Fung, Australia Nobutaka Hattori, Japan Beom S. Jeon, Korea Per Odin, Sweden Ronald F. Pfeiffer, USA K. Ray Chaudhuri, United Kingdom Irena Rektorova, Czech Republik Fabrizio Stocchi, Italy Jon Stoessl, Canada Eng King Tan, Singapore Francesc Valldeoriola, Spain Jens Volkmann, Germany Gregor K. Wenning, Austria Zbigniew K. Wszolek, USA 6 XXI World Congress on Parkinson’s Disease and Related Disorders COMMITTEES INDUSTRY LIAISON COMMITTEE Fabrizio Stocchi, Italy (Chair) Roongroj Bhidayasiri, Thailand K. Ray Chaudhuri, United Kingdom Dirk Dressler, Germany Heinz Reichmann, Germany Daniel Truong, USA Erik Ch. Wolters, The Netherlands Moussa Youdim, Israel PROCEEDINGS COMMITTEE Zbigniew K. Wszolek, USA (Chair) Angelo Antonini, Italy Vincenzo Bonifati, The Netherlands Susan Calne, Canada Jonathan Carr, South Africa Ronald F. Pfeiffer, USA Robert Rodnitzky, USA Eng Kin Tan, Singapore Erik Ch. Wolters, The Netherlands ABSTRACT COMMITTEE Erik Ch. Wolters, The Netherlands (Chair) Angelo Antonini, Italy Peter Riederer, Germany TRAVEL AWARDS COMMITTEE Erik Ch. Wolters, The Netherlands (Chair) Alessandro Di Rocco, USA 7 XXI World Congress on Parkinson’s Disease and Related Disorders TRAVEL AWARDS 8 TRAVEL AWARDS Congress Travel Awards are sponsored by the Melvin Yahr International Parkinson’s Disease Foundation (Chaired by Dr. Alessandro Di Rocco) and the International Association of Parkinsonism and Related Disorders. The awards are aimed to promote participation at the Congress by young researchers under the age of 35. Congratulations to all awardees. Abdellatif Abbaoui, Morocco Chahidi Abderrahmane, Morocco Ikbol Abdukadirova, Uzbekistan Assiya Akanova, Kazakhstan Karthick Kumar Alagamuthu, India Cristina Alcacer, Spain Vivian Altmann, Brasil Tania Álvarez Avellón, Spain Nilesh Ambhore, India Sina Asaadi, Iran Dilorom Ayupova, Uzbekistan Anvar Azimov, Uzbekistan Sneha Banavara, India Ela Barcelon, Philippines Melinda Barkhuizen, South Africa Rui Duarte Barreto, Portugal Sarvar Bebitov, Uzbekistan Seti Belay, Ethiopia Alice Biosa, Italy Lalit Pratap Chandravanshi, India Nargiza Chekeeva, Kyrgyz Republic Maria Chondrogiorgi, Greece Chi-Jing Choong, Malaysia Alin Ciobica, Romania Ilaria Cova, Italy Maria Diez Cirarda, Spain Vidyadhara Dj, India Sojida Djalilova, Uzbekistan Farangisbonu Doniyorova, Uzbekistan Maria Magdalena Dumitru, Romania Roberto Erro, Italy Zhangqiuzi Fan, China Monika Figura, Poland Ndiaga Matar Gaye, Senegal Hanneke Geut, The Netherlands Elvina Giyazitdinova, Uzbekistan Daniela Gonçalves, Portugal Alicia González Martínez, Spain Deepali Gupta, India Richa Gupta, India Ron Terry Gurel, Israel Sabrina Guzzetti, Italy Kristina Harutyunyan, Armenia Stephanie Hirschbichler, Austria Ekaterina Ilicheva, Russia Elena Ivanova, Russia Mahalakshmi Iyer, India Shyam Jaiswal, India Joy Jibin, India Mirzo Juraev, Uzbekistan Stefania Kalampokini, Greece Kovendan Kalimuthu, India Kunduz Karbozova, Kyrgyz Republic Sofiya Khachaturyan, Armenia Mukhlisa Khanova, Uzbekistan Kamola Khasanova, Uzbekistan Nino Khizanishvili, Georgia Nataliia Kozhemiako, Ukraine Gokul Krishna, India Akanksha Kulshreshtha, India Nitin Kumar, India Pardeep Kumar, India Oybek Kurbanov, Uzbekistan Magdalena Kurnik, Poland Wafaa Laabbar, Morocco Navya Lakkappa, India Abhishenk Lenka, India Jia Liu, China Mahmoud Loftinia, Iran Olaia Lucas Jimenez, Spain XXI World Congress on Parkinson’s Disease and Related Disorders Mustaq Ahamed Shafi, India Sarvi Sharifi, The Netherlands Anuradha Sharma, India Vinod Kumar Sharma, India Vikas Sharma, India Neha Sharma, India Sorabh Sharma, India Ranjit Singh, India Enda Cindylosa Sitepu, Indonesia Nodirjon Sokhibnazarov, Uzbekistan Pranay Srivastava, India Anna Strasz, Poland Albert Stezin Sunny, India Natalia Szejko, Poland Marat Tadjenov, Uzbekistan Joy Lynn Tan, Singapore Lokesh Thangamani, India Dilshod Tolibov, Uzbekistan Oybek Turgunkhujaev, Uzbekistan Djahangir Tursunov, Uzbekistan Anahit Voskanyan, Armenia Amha Meshesha Weldehana, Ethiopia Rajesh Singh Yadav, India Farkhod Yunusov, Uzbekistan TRAVEL AWARDS Elena Lyashenko, Russia Antonella Macerollo, Italy Manjunath Mahadevappa, India Irina Miliukhina, Russia Sanjarbek Mirdedayev, Uzbekistan Mari Anne Kristin Moll, Philippines Tim Moors, The Netherlands Elisavet Moti, Greece Bakhrom Muinjonov, Uzbekistan Somnath Mukherjee, India Rajini Naduthota, India Nodir Nurmetov, Uzbekistan Simone Olgiati, Italy Manuela Padurariu, Romania Pankaj Pandey, India Fawaz Pullishery, India Marialuisa Quadri, Italy Sumit Rajput, India Jayalakshmi Ramalingam, India Gretchen Reynolds, USA Anna Sauerbier, Germany Emma Scelzo, Italy Alice Serafin, Italy Irina Serbanoiu, Romania Agostino Seresini, Italy 9 XXI World Congress on Parkinson’s Disease and Related Disorders CME ACCREDITATION 10 CME ACCREDITATION The XXI World Congress on Parkinson’s Disease and Related Disorders is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net. The XXI World Congress on Parkinson’s Disease and Related Disorders is designated for a maximum of 20 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/ she actually spent in the educational activity. Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits™. Information on the process to convert EACCME credit to AMA credit can be found at www.ama-assn.org/go/internationalcme. Live educational activities, occurring outside of Canada, recognized by the UEMS-EACCME for ECMEC credits are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of The Royal College of Physicians and Surgeons of Canada. The CME questionnaire and certificate will be available on the Congress website www.oic.it/iaprd2015 from 10 December 2015 to 6 January 2016. Please note that the registration code, printed on your badge is necessary to access the CME questionnaire and to print out your certificate. XXI World Congress on Parkinson’s Disease and Related Disorders THIS IS NO ORDINARY MEETING One of the most interesting aspects of the XXI World Congress on Parkinson’s Disease and Related Disorders is the diversity of approaches presented. This allows for original solutions to be discussed for a wide range of problems, both on research and clinical management. Needless to say, the contact between neurologists working in different countries is vital for such an exchange to take place. Presentations are geared to various levels of skills, so that participants from a variety of backgrounds will have the chance to enrich their knowledge and enjoy the networking opportunities. Delegates will find that there is an exciting range of subjects in main lectures, parallel sessions, interactive and educational sessions, symposia and poster sessions. The emphasis is on discussion and on a positive critical attitude. Language difficulties and hierarchical divisions may have hindered scientific discussion in other meetings, however IAPRD congresses have managed to rise above both barriers. We now look forward to the involvement of all participants, be it in open forums during all the sessions, or at a more personal “one to one” level. SCIENTIFIC INFORMATION SCIENTIFIC INFORMATION THE XXI IAPRD CONGRESS – HIGHLIGHTS The wide range of topics included in the program will be presented by international experts. Lectures, symposia, session summaries, and discussions will be led by experienced moderators while educational sessions and updates will summarize on the newest aspects. As customary, a considerable amount of platform time will be given over to discussion. A further opportunity is the Technical Exhibition, where novelties may be explored and where delegates will have the chance to liaise with industry representatives. The Congress will address all aspects of movement disorders including basic science, genetics, differential diagnosis and therapeutic interventions. OFFICIAL LANGUAGE The official language of the International Association Parkinsonism and Related Disorders is English. All participants are encouraged to join discussions, independently of their fluency in English as the exchange of ideas and critical evaluation of presentations is the main purpose of the entire Congress. 11 XXI World Congress on Parkinson’s Disease and Related Disorders SCIENTIFIC INFORMATION PLENARY SESSIONS There will be seven Plenary Sessions, covering the main topics of the Congress, delivered by leading clinical experts, basic scientists and other health care professionals. PARALLEL SESSIONS They will focus on specific topics, regarding clinical and/or basic science aspects in the field of movement disorders, representing several points of view. INTERACTIVE SESSIONS They are planned on Monday and Tuesday program. Debates will offer a lively and hopefully fruitful discussion on controversial issues. EDUCATIONAL SESSIONS They will cover all aspects of Parkinson’s disease and other movement disorders, and will serve the educational mission of the IAPRD. SPECIAL SESSION “PAST, PRESENT AND FUTURE OF TECHNOLOGY FOR PARKINSON DISEASE” On Tuesday 8 December from 13.00 to 15.00 in Yellow Hall 3 the World Federation of Neurology (WFN) program “Past, Present and Future of Technology for Parkinson Disease” will take place. It is a session to educate clinicians and researchers about some of the technologies available for assessing and monitoring different aspects of Parkinson’s disease and related disorders. The program will provide a framework to categorize the many technological options that are quickly becoming available in both clinical and research environments. There will be a discussion of the role of non-profit entities in the development of tools as well as how to integrate others into decision-making (including the role of the patient). Potential shortcomings, unmet needs and possible opportunities will also be highlighted. ORAL POSTER PRESENTATIONS 97 selected posters have been given the opportunity to present a 6-minutes short oral presentation of their abstract. And another 12 have been selected to present their data in a 12-minutes presentation during the Selected Topics Sessions. 12 XXI World Congress on Parkinson’s Disease and Related Disorders SLIDE CENTRE The Slide Centre is situated on level +1. All meeting rooms are equipped with a computer slide projector alone, and no traditional slide or overhead projectors for transparencies are available. It will be not possible to use personal laptops in the meeting rooms. Speakers are kindly requested to use “PowerPoint” (Windows or Macintosh/Apple) for their presentations. The dimensions of PowerPoint presentation should not exceed 300 MB, videos included. Please use “.gif ” and “.jpg” extensions for images. Other types of extensions will be accepted provided they can be recognized by PowerPoint. The use of CD-Rom, pens or memory stick is advisable to ease downloading of presentations, and same should be handed to technicians at the Slide Centre in good time. Please remember to collect your CD or memory pen from the Slide Centre at the end of the session. Speakers with PowerPoint presentation on CD Rom or memory pen: please report to the Slide Centre at least one hour before your presentation or the day before if you are scheduled to speak in the morning. Speakers with presentation on personal laptops: please report to the Slide Centre at least four hours before your presentation or the day before, if scheduled in the morning. This timing will allow your presentation to be downloaded onto the main computer. SCIENTIFIC INFORMATION POSTERS Authors are required to attach their posters to the appropriate poster board. Posters will be displayed with a daily rotation on Monday 7, Tuesday 8 and Wednesday 9 December. Poster boards will be duly numbered and set up material will be provided by the Organizing Secretariat. Dates and times of Poster Session discussions are indicated in the program at a glance and in the scientific program. Authors are expected to be present at their poster board during discussion. 13 XXI World Congress on Parkinson’s Disease and Related Disorders PROGRAM AT A GLANCE SUNDAY, 6 DECEMBER 2015 Silver Hall Red Hall 2 10.30 12.00 12.30 Red Hall 1 Yellow Hall 3 Diagnosis of Parkinson’s disease Oral Poster Session (1.30.01-1.30.12) Pre-Congress Symposium Recognition of life-long curiosity in Parkinson’s disease etiopathogenesis Break Genetics What is new in synucleinopathies 14.00 Break 14.30 Update on other degenerative What is new in tauopathies Mental dysfunction in movement disorders Parkinson’s disease 16.00 Break 16.30 PD pharmacotherapeutical interventions 18.00 18.30 Oral Poster Session (1.30.13-1.30.24) Break Opening Ceremony 20.00 Welcome Reception (Exhibition Area) MONDAY, 7 DECEMBER 2015 Silver Hall Red Hall 2 8.30 Behavioural disorders Advances in in parkinsonism Parkinson’s disease imaging (1) 10.00 10.15 Parkinson’s disease non-pharmacological interventions 11.45 12.00-13.30 (Exhibition Area) Visit Exhibition POSTER SESSION I (1.001-2.036) 12.45 SELECTED TOPIC SESSION (2.60.01-2.60.06) 13.00-13.30 Lunch (Exhibition Area) 13.45 What exactly do the basal ganglia do? 15.15 15.30 17.00 17.15 14 18.45 Iatrogenic motor disorders Update on sleep disorders Blue Hall Red Hall 1 Yellow Hall 3 Unusual movement disorders (1) Genetics Oral Poster Session (2.50.01-2.50.12) Short break Industry Sponsored Symposium 1 Industry Sponsored Symposium 2 Short break Interactive discussion Management of clinical-geneticParkinson’s disease pathological cases complications Oral Poster Session (2.50.13-2.50.24) Short break Neurorehabilitation for Device-aided Management of Oral Poster Session Parkinson’s disease: Parkinson’s disease autonomic dysfunction (2.50.25-2.50.37) future perspectives treatments: in parkinsonism practical issues XXI World Congress on Parkinson’s Disease and Related Disorders 8.30 Red Hall 2 Blue Hall Red Hall 1 Yellow Hall 3 Interventions in parkinsonism (MSA/ PSP/CBD) Advances in Parkinson’s disease imaging (2) Unusual movement disorders (2) Update on tremor Oral Poster Session (3.50.01-3.50.10) 10.00 10.15 Short break Biomarkers in Parkinson’s disease 11.45 Short break 12.00 Industry Sponsored Symposium 3 Visit Exhibition POSTER SESSION II (2.037-3.087) (Exhibition Area) SELECTED TOPIC SESSION (3.60.01-3.60.06) (Exhibition Area) 13.00-13.30 Lunch (Exhibition Area) 13.30 13.45 Short break Dystonia revisited 15.15 Short break 15.30 Non-motor symptoms in movement disorders 17.00 Neurodegeneration Hands on dystonia: botulinum toxin workshop PROGRAM AT A GLANCE TUESDAY, 8 DECEMBER 2015 Silver Hall Dystonia Short break 17.15 Deep brain stimulation 18.45 Animal models in Diagnostic challenges movement disorders Oral Poster Session 3.50.11-3.50.22 WEDNESDAY, 9 DECEMBER 2015 8.30 Silver Hall Red Hall 2 Red Hall 1 Yellow Hall 3 MD developments 2014-2015: Best PRD Articles Sensor and sleep deficits in Parkinson’s disease Diagnosis of uncommon movement disorders Oral Poster Session (4.50.01-4.50.12) 10.00 Short break 10.15 Cognitive impairment in Parkinson’s disease 11.45 Psychogenic movement disorders 13.15 Visit Exhibition POSTER SESSION III (3.088-6.070) (Exhibition Area) 13.45 Disease associations in movement disorders: controversies 15.15 Closing Ceremony DIRECTORY Plenary Sessions Sponsored Symposia Recent advances in essential tremor Clinical Parallel Sessions Instrumental hallmarks of parkinsonism Translational Interactive Parallel Sessions Sessions Oral Poster Session (4.50.13-4.50.23) Educational Oral Poster Sessions Sessions Exhibition Area 15 UNDER THE PATRONAGE OF SCIENTIFIC PROGRAM XXI World Congress on Parkinson’s Disease and Related Disorders SUNDAY, 6 DECEMBER 10.30-12.00 PRE-CONGRESS SYMPOSIUM RECOGNITION OF LIFE-LONG CURIOSITY IN PARKINSON’S DISEASE ETIOPATHOGENESIS Chairmen: T. Brücke (Austria), P. Riederer (Germany), E.Ch. Wolters (The Netherlands) Committee: T. Brücke (Austria), R. Horowski (Germany), P. Riederer (Germany), M.B.H. Youdim (Israel), E.Ch. Wolters (The Netherlands) 10.30 Japanese pioneers in Parkinson’s disease (introduction by P. Riederer) N. Hattori (Japan) 11.00 Senator-Doktor-Franz-Burda Award: 20 years of gene-hunting in Parkinson’s disease (introduction by T. Brücke) A. Zimprich (Austria) 11.30 The impact of genetic research in movement disorders (introduction by E.Ch. Wolters) Z.K. Wszolek (USA) 12.00 Break 12.30-14.00 CLINICAL PARALLEL SESSION 1.10 GENETICS Chairmen: S. Goldwurm (Italy), E.K. Tan (Singapore) 18 RED HALL 2 12.30 Autosomal dominant Parkinsonism Z.K. Wszolek (USA) 13.00 Autosomal recessive Parkinsonism V. Bonifati (The Netherlands) 13.30 Common and rare risk variants for Parkinsonism O. Ross (USA) SILVER HALL XXI World Congress on Parkinson’s Disease and Related Disorders RED HALL 2 TRANSLATIONAL PARALLEL SESSION 1.20 WHAT IS NEW IN SYNUCLEINOPATHIES Chairmen: P. Riederer (Germany), G.K. Wenning (Austria) 12.30 Alpha-synuclein propagation N.L. Rey (USA) 13.00 Phenotypic spectrum of alpha-synuclein mutations E.M. Valente (Italy) 13.30 Multiple system atrophy-mimics and boundary issues in multiple system atrophy H.-J. Kim (South Korea) 12.30-14.00 SUNDAY, 6 DECEMBER 12.30-14.00 RED HALL 1 EDUCATIONAL PARALLEL SESSION 1.40 DIAGNOSIS OF PARKINSON’S DISEASE Chairmen: E. Melamed (Israel) †, E.Ch. Wolters (The Netherlands) 12.30 Clinical definition E.Ch. Wolters (The Netherlands) 13.00 Pre-motor manifestations A. Iranzo (Spain) 13.30 Non motor manifestations K. Ray Chaudhuri (United Kingdom) 19 XXI World Congress on Parkinson’s Disease and Related Disorders SUNDAY, 6 DECEMBER 12.30-14.00 YELLOW HALL 3 ORAL POSTER SESSION (1.30.01-1.30.12) Chairmen: A. Elia (Italy), E. Fiorenzato (Italy) OP 1.30.01 An unexpected higher prevalence of Parkinson’s disease in females than males in the province of Trento (Italy): a clues for the etiopathogenesis? M.C. Malaguti, N. Vanacore, S. Ferrari, S. Piffer, R. Pertile, R. Roni, A. Polverino, M. Gentilini, F. Cembrani, V. Bertozzi, M. Pellegrini, D. Orrico (Italy) OP 1.30.02 Parkinson’s disease in Senegal: epidemiologic, clinical and therapeutic aspects N.M. Gaye, L.B. Seck, N.S. Diagne, A.D. Sow, A.M. Diop, O. Cisse, A.B. Faye, M.S. Diop, K. Toure, M. Ndiaye, A.G. Diop, M.M. Ndiaye (Senegal) OP 1.30.03 A step forward to the future: UPDRS kinematic measures for telemedicine G. Albani, C. Azzaro, F. Parisi, C. Ferraris, M. Giuberti, L. Contin, D. Pianu, L.G. Pradotto, V. Cimolin, M. Galli, R. Nerino, G. Ferrari, A. Mauro (Italy) OP 1.30.05 Longer duration of Parkinson’s disease is associated with reduced prevalence of hypertension V. Brandi, D. Vetrano, M.S. Pisciotta, M.R. Lo Monaco, A. Laudisio, G. Onder, R. Bernabei, G. Zuccalà (Italy) OP 1.30.06 Gastroesophageal dysmotility in advanced Parkinson’s disease F. Mancini, L. Manfredi, M. Lacerenza, C. Colombo A. Bestetti (Italy) OP 1.30.07 Speech disorders and Parkinson’s disease M. Pettorino, E. Pellegrino, M.G. Busà (Italy) OP 1.30.08 An alternative perspective on interpretation of the secondary motor symptoms of Parkinson’s disease L. Vucolova (USA) OP 1.30.09 An alternative perspective on interpretation of the cardinal motor symptoms of Parkinson’s disease L. Vucolova (USA) OP 1.30.10 Falling direction is important predictors for mechanism of falls in patients with Parkinson’s disease J. Youn, M. Hwang, D. Kim, J.W. Cho (South Korea) OP 1.30.11 Frequency and risk of falls in Parkinson’s disease in Ibadan T. Farombi, M. Owolabi, A. Ogunniyi (Nigeria) OP 1.30.12 Falls in Parkinson’s disease: effects on health related quality of life T. Farombi, J. Yaria, M. Owolabi, A. Ogunniyi (Nigeria) 14.00 20 Break XXI World Congress on Parkinson’s Disease and Related Disorders SILVER HALL CLINICAL PARALLEL SESSION 1.11 UPDATE ON OTHER DEGENERATIVE MOVEMENT DISORDERS Chairmen: F. Cardoso (Brazil), G.B. Landwehrmeyer (Germany) 14.30 Huntington disease G.B. Landwehrmeyer (Germany) 15.00 Spino-cerebellar ataxia A. Dürr (France) 15.30 Neurodegenerations with brain iron accumulation S.A. Schneider (Germany) 14.30-16.00 RED HALL 2 SUNDAY, 6 DECEMBER 14.30-16.00 TRANSLATIONAL PARALLEL SESSION 1.21 WHAT IS NEW IN TAUOPATHIES Chairmen: C. Colosimo (Italy), B.S. Jeon (South Korea) 14.30 Phenotypic spectrum G. Höglinger (Germany) 15.00 Neuropathology D. Irwin (USA) 15.30 Imaging biomarkers D.J. Brooks (Denmark) 14.30-16.00 RED HALL 1 EDUCATIONAL PARALLEL SESSION 1.41 MENTAL DYSFUNCTION IN PARKINSON’S DISEASE Chairman: J. Kulisevsky (Spain) 14.30 Cognitive deterioration J. Kulisevsky (Spain) 15.00 Depression P. Barone (Italy) 15.30 Psychosis T. van Laar (The Netherlands) 21 XXI World Congress on Parkinson’s Disease and Related Disorders SUNDAY, 6 DECEMBER 14.30-16.00 YELLOW HALL 3 ORAL POSTER SESSION (1.30.13-1.30.24) Chairmen: A. Elia (Italy), F. Mancini (Italy) OP 1.30.13 A prospective study of cumulative incidence and course of RLS in de novo PD patients during chronic dopaminergic therapy S. Calzetti, E. Marchesi, M. Goldoni, A. Negrotti (Italy) OP 1.30.14 Semantic and phonemic verbal fluency in patients with Parkinson’s disease (PD) A.D. Roesch, A. Meyer, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) OP 1.30.15 Emotion recognition and emotion expression in Parkinson’s disease: an unifying emotional mirror mechanism? L. Ricciardi, F. Visco-Comandini, R. Erro, F. Morgante*, M. Bologna*, A. Fasano**, D. Ricciardi*, M. Edwards, J. Kilner (United Kingdom, *Italy, **Canada) OP 1.30.16 Association of depressive symptoms with circadian blood pressure alterations in Parkinson’s disease M.S. Pisciotta, D.L. Vetrano, V. Brandi, M.R. Lo Monaco, A. Laudisio, D. Fusco, G. Onder, R. Bernabei, G. Zuccalà (Italy) OP 1.30.17 Blood biomarkers associated with cognitive decline in early stage and drug-naive Parkinson’s disease patients J. Santiago, J. Potashkin (USA) OP 1.30.18 Impact of gender on impulse control disorders and other non-motor symptoms among Parkinson’s disease patients N. Kovács, G. Deli, Z. Aschermann, A. Makkos, J. Janszky, M. Kovács (Hungary) OP 1.30.19 Effects of Parkinson’s disease on cognitive action control: insights on impulsive response tendencies using an oclomotor Simon task J. Duprez, J. Houvenaghel, S. Argaud, M. Vérin, P. Sauleau (France) OP 1.30.20 Sensory attenuation and Parkinson’s disease: a new pathophysiological framework of bradykinesia A. Macerollo, J. Chen, P. Korlipara, T. Foltynie, J. Rothwell, M. Edwards, J. Kilner (United Kingdom) OP 1.30.21 Fine motor function skills in patients with Parkinson’s disease (PD) with and without mild cognitive impairment (MCI) P. Dahdal, A. Meyer, M. Chaturvedi, K. Nowak, A.D. Roesch, U. Gschwandtner, P. Fuhr (Switzerland) OP 1.30.24 Continuous monitoring of PD with an affordable novel computerised motor test based on a tablet M. Da Lio, M. De Cecco, P. Bosetti, M. Malaguti (Italy) 16.00 22 Break XXI World Congress on Parkinson’s Disease and Related Disorders SILVER HALL PLENARY SESSION 1.1 PARKINSON’S DISEASE PHARMACOTHERAPEUTICAL INTERVENTIONS Chairman: E.Ch. Wolters (The Netherlands) 16.30 Parkinson’s disease-related non-motor symptoms K. Ray Chaudhuri (United Kingdom) 17.00 Levodopa based strategies P.A. LeWitt (USA) 17.30 Enzyme-based strategies F. Stocchi (Italy) 18.30-20.00 SUNDAY, 6 DECEMBER 16.30-18.00 SILVER HALL PLENARY SESSION OPENING CEREMONY Welcoming words by the IAPRD President and the Congress Chair E.Ch. Wolters (The Netherlands), A. Antonini (Italy) Welcoming words L. Battistin (Italy) A. Berardelli (Italy) Transplantation in Parkinson’s disease A. Bjorklund (Sweden) 23 XXI World Congress on Parkinson’s Disease and Related Disorders MONDAY, 7 DECEMBER 8.30-10.00 SILVER HALL CLINICAL PARALLEL SESSION 2.10 BEHAVIOURAL DISORDERS IN PARKINSONISM Chairmen: D. Aarsland (Sweden), J. Kulisevsky (Spain) 8.30 Impulsivity and compulsivity in Parkinson’s disease M. Samuel (United Kingdom) 9.00 Psychosis M. Onofrj (Italy) 9.30 Deep brain stimulation-effect on emotions and behaviour E. Moro (France) 8.30-10.00 RED HALL 2 TRANSLATIONAL PARALLEL SESSION 2.20 ADVANCES IN PARKINSON’S DISEASE IMAGING (1) Chairmen: U. Bonuccelli (Italy), A. Strafella (Canada) 8.30 Optimizing diagnosis in Parkinson’s disease A.J. Stoessl (Canada) 9.00 Structural connectivity A. Tessitore (Italy) 9.30 Functional connectivity I. Rektorova (Czech Republic) 8.30-10.00 BLUE HALL INTERACTIVE PARALLEL SESSION 2.30 UNUSUAL MOVEMENT DISORDERS (1) - video session Coordinator: F. Morgante (Italy) Speakers: F. Morgante (Italy), F. Cardoso (Brazil), M. Stamelou (Greece) 24 XXI World Congress on Parkinson’s Disease and Related Disorders RED HALL 1 EDUCATIONAL PARALLEL SESSION 2.40 GENETICS Chairmen: V. Bonifati (The Netherlands), E. Melamed (Israel) † 8.30 Genetics of Parkinson’s disease - Genotypes V. Bonifati (The Netherlands) 9.00 Genetics of Parkinson’s disease - Phenotypes Z.K. Wszolek (USA) 9.30 Genetic entities mimicking Parkinson’s Disease O. Ross (USA) 8.30-10.00 YELLOW HALL 3 MONDAY, 7 DECEMBER 8.30-10.00 ORAL POSTER SESSION (2.50.01-2.50.12) Chairmen: A. Elia (Italy), I. Isaias (Germany) OP 2.50.01 Relationship between stay-at-home patients’ understanding of nformation regarding their Parkinson’s disease and the burden of spouse caregivers H. Takamoto, M. Hori (Japan) OP 2.50.02 Restoration of tensegrity equilibrium can lead to beneficial modification of Parkinson disease’s motor symptoms L. Vucolova (USA) OP 2.50.03 Use of three-dimensional gait analysis to assess the effectiveness of conventional rehabilitation protocols in people with Parkinson’s disease M. Pau, F. Corona, C. Casula, R. Pili, M. Murgia, M. Guicciardi (Italy) OP 2.50.04 The worse is the clinical status of the patient with Parkinson, the higher is the stride length percentage of improvement after automated mechanical peripheral stimulation A. Kleiner, M. Galli, M. Gaglione, D. Hildebrand*, P. Sale, G. Albertini, F. Stocchi, M.F. De Pandis (Italy, *Brazil) OP 2.50.05 Stress Reduction Training in PD Patients - Influence on neuropsychiatric symptoms? A. Meyer, A. Hadinia, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) OP 2.50.06 Cognitive Behavioral Group Therapy (CBT) for stress reduction in patients with Parkinson’s disease. A randomized control trial A. Hadinia, A. Meyer, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) OP 2.50.07 Quality of life measured by PDQ39 and SEIQoL during anti-stress training for Parkinson’s disease (PD) patients K. Nowak, A. Meyer, M. Chaturvedi, A. Hadinia, U. Gschwandtner, P. Fuhr (Switzerland) 25 XXI World Congress on Parkinson’s Disease and Related Disorders MONDAY, 7 DECEMBER OP 2.50.08 Cortisol measurements as a laboratory biomarker for stress reduction in Parkinson’s disease (PD) patients K. Nowak, A. Meyer, A. Hadinia, M. Chaturvedi, A.D. Roesch, U. Gschwandtner, P. Fuhr (Switzerland) OP 2.50.09 Effects of cognitive loading on standing balance and postural stability in Parkinson’s disease patients with freezing of gait W. Buated, P. Lolekha*, T. Fujinami, S. Hidaka, N. Kashyap (Japan, *Thailand) OP 2.50.10 Theatre is a valid complementary therapeutic interventions for emotional rehabilitation of Parkinson’s patients G. Mirabella, P. De Vita, S. Rampelli, F. Lena, F. Dilettuso, M. Iacopini, R. D’Avella, M.C. Borghese, S. Mazzotta, D. Lanni, M. Grano, S. Lubrani, N. Modugno (Italy) OP 2.50.11 Pharmaceutical design in Parkinson’s disease: what do patients prefer? K. Lefteri, F. Liu, M. Brown (United Kingdom) OP 2.50.12 Unlocking Alzheimers and Parkinsonism - Do you dream for cure? J. Joy (India) 10.00 Short break 10.15-11.45 SILVER HALL PLENARY SESSION 2.1 PARKINSON’S DISEASE NON-PHARMACOLOGICAL INTERVENTIONS Chairmen: A. Antonini (Italy), G. Pezzoli (Italy) 26 10.15 Rehabilitation G. Abbruzzese (Italy) 10.45 Transcranial stimulation A. Priori (Italy) 11.15 Genetic, dietary and pharmacological determinants of urate and their impact on Parkinson’s disease M.A. Schwarzschild (USA) XXI World Congress on Parkinson’s Disease and Related Disorders EXHIBITION AREA SELECTED TOPIC SESSION (2.60.01-2.60.06) Chairmen: A. Elia (Italy), I. Isaias (Germany) OP 2.60.01 An explorative assessment of antioxidant and inflammatory biomarkers for identification of prodromal Parkinson’s disease (PD) J. Campolo, R. De Maria, L. Cozzi, M. Parolini, P. Proserpio, L. Nobili, G. Gelosa, I. Piccolo, P. Marraccini (Italy) OP 2.60.02 Autonomic dysfunction in Parkinson’s disease associated with common glucocerebrosidase gene mutations F. Del Sorbo, A.E. Elia, L.M. Romito, P. Soliveri, C. Barzaghi, B. Garavaglia, P. Cortelli, A. Albanese (Italy) OP 2.60.03 Impulsive-compulsive behaviors in Parkin-associated Parkinson’s disease: a case-control study F. Morgante, A. Fasano*, M. Ginevrino, S. Petrucci, L. Ricciardi**, F. Bove, C. Criscuolo, M. Moccia, A.R. Bentivoglio, M.T. Pellecchia, G. Di Michele**, P. Barone, E.M. Valente (Italy, *Canada, **United Kingdom) MONDAY, 7 DECEMBER 12.00-13.30 OP 2.60.04 Recognition of life-long curiosity in Parkinson’s disease treatment developments P. Riederer (Germany) OP 2.60.05 Effect of pharmacist-led interventions on motor symptoms in Parkinson’s patients: a pilot study C. Stuijt, T. Van Laar (The Netherlands) OP 2.60.06 Long-term effectiveness of NUPLAZID™ (pimavanserin) in PD psychosis: Data from 2 open-label studies R. Mills, S. Isaacson, J. Azulay*, J. Ferreira**, D. Kreitzman, T. Ilic***, K. Chi-Burris, H. Williams (USA, *France, **Portugal, ***Serbia) 12.00-13.30 EXHIBITION AREA POSTER SESSION I (1.001-2.036) 27 XXI World Congress on Parkinson’s Disease and Related Disorders MONDAY, 7 DECEMBER 13.45-15.15 SILVER HALL PLENARY SESSION 2.2 WHAT EXACTLY DO THE BASAL GANGLIA DO? Chairmen: A. Berardelli (Italy), A.M. Cenci Nilsson (Sweden) 13.45 Volitional moving M. Hallett (USA) 14.15 Role of (in)direct pathway in action control R.M. Costa (Portugal) 14.45 Basal ganglia modulation of limbic circuits in learning and memory processes P. Calabresi (Italy) 15.15 Short break 15.30-17.00 SILVER HALL CLINICAL PARALLEL SESSION 2.11 IATROGENIC MOTOR DISORDERS Chairmen: A.J. Espay (USA), M. Stamelou (Greece) 15.30 Clinical phenotype A.J. Espay (USA) 16.00 Imaging characterization M. Tinazzi (Italy) 16.30 Therapeutic approach F. Morgante (Italy) 15.30-17.00 TRANSLATIONAL PARALLEL SESSION 2.21 UPDATE ON SLEEP DISORDERS Chairmen: P. Cortelli (Italy), A. Iranzo (Spain) 28 15.30 Restless eye movement behavior disorder L. Ferini-Strambi (Italy) 16.00 Excessive daytime sleepiness and sleep attacks C. Baumann (Switzerland) 16.30 Restless legs syndrome C. Bassetti (Switzerland) RED HALL 2 XXI World Congress on Parkinson’s Disease and Related Disorders BLUE HALL INTERACTIVE PARALLEL SESSION 2.31 INTERACTIVE DISCUSSION CLINICAL-GENETIC-PATHOLOGICAL CASES Coordinator: C. Adler (USA) Speakers: C. Adler (USA), N. Hattori (Japan), W.D.J. van de Berg (The Netherlands) 15.30-17.00 RED HALL 1 EDUCATIONAL PARALLEL SESSION 2.41 MANAGEMENT OF PARKINSON’S DISEASE COMPLICATIONS Chairman: P. Odin (Sweden) 15.30 Motor complications P. Odin (Sweden) 16.00 Non-motor fluctuations A. Storch (Germany) 16.30 Impulse control disorders M.C. Rodriguez-Oroz (Spain) 15.30-17.00 MONDAY, 7 DECEMBER 15.30-17.00 YELLOW HALL 3 ORAL POSTER SESSION (2.50.13-2.50.24) Chairman: R. Cilia (Italy) OP 2.50.13 Pharmacogenetics of levodopa: an algorithm for dose prediction V. Altmann, M. Rieck, A. Schumacher-Schuh, S. Callegari-Jacques, C. de Mello Rieder, M. Hutz (Brazil) OP 2.50.14 Treatment with l-dopa normalize learning as measured with CVLT-2 in drug naive patients with Parkinsons`disease H.T.J. Sari, O.B. Tysnes, J.P. Larsen, A. Gramstad, G.O. Skeie (Norway) OP 2.50.16 Onset and duration of motor effects with IPX066, levodopa-carbidopa extended-release capsules: comparison with immediate-release levodopa-carbidopa and with levodopa-carbidopa+entacapone S. Gupta, S. Khanna, R. Rubens, N. Modi (USA) OP 2.50.17 Outpatient levodopa-carbidopa intestinal gel titration in patients with advanced Parkinson’s disease R. Rodriguez, M. Lobatz, J. Dubow, S. Eaton, C. Hall, K. Chatamra, J. Benesh (USA) OP 2.50.18 Effects of levodopa-carbidopa intestinal gel on non-motor symptoms and safety of outpatient titration: a new phase 3 study in patients with advanced Parkinson’s disease D. Standaert, J. Slevin, C. Hall, J. Dubow, S. Eaton, K. Chatamra, J. Benesh (USA) 29 XXI World Congress on Parkinson’s Disease and Related Disorders MONDAY, 7 DECEMBER OP 2.50.19 Determination of minimal important difference thresholds for Parkinson’s Disease Questionnaire-39 in advanced Parkinson’s disease patients A. Antonini, E. Dansie Bacci*, K. Sail*, Y.J. Jalundhwala*, P.L. Kandukuri*, T. Marshall*, K. Chatamra*, I. Wiklund**, D. Revicki* (Italy, *USA, **United Kingdom) OP 2.50.20 Gastrointestinal safety of levodopa-carbidopa intestinal gel in advanced Parkinson’s disease patients: GLORIA long-term registry interim results D. Domagk, S. Dam-Larsen*, **A. Antonini, L. Bergmann***, A. Yegin***, W. Poewe**** (Germany, *Denmark, **Italy, ***USA, ****Austria) OP 2.50.21 Antiparkinsonian medication adjustments following deep brain stimulation of subthalamic nucleus in patients with advanced Parkinson’s disease A. Gamaleya, E. Bril, A. Tomskiy, N. Gubareva, A. Poddubskaya, N. Fedorova, V. Shabalov (Russia) OP 2.50.22 Comparison of the antiparkinsonian and antidyskinetic effects of hemantane and amantadine E. Ivanova, I. Kapitsa, E. Valdman, T. Voronina (Russia) OP 2.50.24 A study of real life tolerability of rotigotine transdermal patch in Parkinson’s disease across all motor stages R. Barreto, A. Sauerbier, A. Rizos, R. Chaudhuri (United Kingdom) 17.00 Short break 17.15-18.45 RED HALL 2 TRANSLATIONAL PARALLEL SESSION 2.22 NEUROREHABILITATION FOR PARKINSON’S DISEASE: FUTURE PERSPECTIVES Chairmen: G. Abbruzzese (Italy), K.B. Bhattacharyya (India) 30 17.15 Gait and posture J.-P. Azulay (France) 17.45 Behavioural adaptation B.R. Bloem (The Netherlands) 18.15 Exercise M. Hirsch (USA) XXI World Congress on Parkinson’s Disease and Related Disorders BLUE HALL INTERACTIVE PARALLEL SESSION 2.32 DEVICE-AIDED PARKINSON’S DISEASE TREATMENTS: PRACTICAL ISSUES Chairmen: E. Dietrichs (Norway), L. Lopiano (Italy) 17.15 Selecting the right patient P. Odin (sweden) 17.45 Infusion therapies T. van Laar (The Netherlands) 18.15 Deep brain stimulation F. Valldeoriola (Spain) 17.15-18.45 MONDAY, 7 DECEMBER 17.15-18.45 RED HALL 1 EDUCATIONAL PARALLEL SESSION 2.42 MANAGEMENT OF AUTONOMIC DYSFUNCTION IN PARKINSONISM Chairman: H. Kaufmann (USA) 17.15 Blood pressure H. Kaufmann (USA) 17.45 Urogenital P. Cortelli (Italy) 18.15 Gastrointestinal F. Stocchi (Italy) 19.00-20.30 WHITE HALL 1 ANNUAL GENERAL MEETING 31 XXI World Congress on Parkinson’s Disease and Related Disorders MONDAY, 7 DECEMBER 17.15-18.45 YELLOW HALL 3 ORAL POSTER SESSION (2.50.25-2.50.37) Chairmen: R. Cilia (Italy), P. Martinez-Martin (Spain), G. Riboldazzi (Italy) OP 2.50.25 Rotigotine efficacy on sleep disturbances in Parkinson’s Disease patients: evidence from a polysomnographic study C. Liguori, M. Pierantozzi, F. Placidi, A. Stefani (Italy) OP 2.50.26 Efficacy of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson’s disease A. Agro, J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, H. Shill*, R. Hauser* (Canada, *USA) OP 2.50.27 Baseline disease severity not predictive of sublingual apomorphine (APL-130277) dose needed to convert a PD patient from the OFF to ON state J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, A. Agro (Canada) OP 2.50.28 Minimum MDS-UPDRS part iii change needed to convert a Parkinson’s disease patient from the OFF to full ON state with sublingual apomorphine (APL-130277) J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, A. Agro (Canada) OP 2.50.29 Differences between apomorphine (APO) and lisuride (LIS) in PD therapy R. Horowski (Germany) OP 2.50.30 The effect of bilateral sub-thalamic nucleus deep brain stimulation (STN-DBS) on prosody of speech of Parkinson’s disease F. Majdinasab, S.A.H. Habibi, E. Ghorbani, M. Khoddami (Iran) OP 2.50.31 Can intraoperative clinical testing predict stimulation-induced effects of STN-DBS? J. Blume, E. Rothenfußer-Korber, A. Janzen, U. Bogdahn, J. Schlaier, M. Lange (Germany) OP 2.50.32 The impact of microelectrode recording on selecting the most optimal trajectories for electrode implantation M. Nagy, N. Kovács, Z. Aschermann, G. Deli, I. Balás (Hungary) OP 2.50.33 Reflex saccades evaluation can estimate long-term symptom progression in DBS STN vs only medically treated Parkinson’s disease patients S. Szlufik, A. Przybyszewski, J. Dutkiewicz, P. Habela, T. Mandat, D. Koziorowski (Poland) OP 2.50.34 High frequency repetitive transcranial magnetic stimulation can improve the quality of life and depression in Parkinson’s disease: a randomized, double-blind, placebo-controlled study N. Kovács, G. Deli, Z. Aschermann, A. Makkos, M. Kovács, J. Janszky, E. Pál (Hungary) OP 2.50.35 The impact of STN DBS on kinetic tremor in Parkinson’s disease patients S. Szlufik, M. Szumilas, J. Dutkiewicz, D. Koziorowski, T. Mandat, E. Slubowska (Poland) OP 2.50.36 The combined depletion of monoamines alters the effectiveness of subthalamic deep brain stimulation E. Faggiani, C. Delaville, A. Benazzouz (France) 32 OP 2.50.37 Unilateral deep brain stimulation of subthalamic nuclei does not affect reactive inhibition in Parkinson’s patients G. Mirabella, G. Giannini, M. Fragola, M. Santilli, N. Modugno (Italy) XXI World Congress on Parkinson’s Disease and Related Disorders SILVER HALL CLINICAL PARALLEL SESSION 3.10 INTERVENTIONS IN PARKINSONISM (MULTIPLE SYSTEM ATROPHY/PROGRESSIVE SUPRANUCLEAR PALSY/CORTICO BASAL DEGENERATION) Chairmen: C. Colosimo (Italy), G. Höglinger (Germany) 8.30 Multiple system atrophy G.K. Wenning (Austria) 9.00 Progressive supranuclear palsy M. Stamelou (Greece) 9.30 Cortico basal degeneration C. Colosimo (Italy) 8.30-10.00 TUESDAY, 8 DECEMBER 8.30-10.00 RED HALL 2 TRANSLATIONAL PARALLEL SESSION 3.20 ADVANCES IN PARKINSON’S DISEASE IMAGING (2) Chairmen: I. Rektorova (Czech Republic), M. Samuel (United Kingdom) 8.30 Biomarkers of atypical Parkinsonism A. Antonini (Italy) 9.00 Imaging correlates of Parkinson cognitive impairment R. Biundo (Italy) 9.30 Molecular imaging and neural networks in impulse control disorders A. Strafella (Canada) 8.30-10.00 BLUE HALL INTERACTIVE PARALLEL SESSION 3.30 UNUSUAL MOVEMENT DISORDERS (2) - Video Session Coordinator: A.J. Espay (USA) Speakers: K. Bhatia (United Kingdom), F. Cardoso (Brazil), A.J. Espay (USA) 33 XXI World Congress on Parkinson’s Disease and Related Disorders TUESDAY, 8 DECEMBER 8.30-10.00 RED HALL 1 EDUCATIONAL PARALLEL SESSION 3.40 UPDATE ON TREMOR Chairmen: A. Friedman (Poland), R. Helmich (The Netherlands) 8.30 Tremor: Pathophysiology R. Helmich (The Netherlands) 9.00 Tremor: Clinical aspects E.D. Louis (USA) 9.30 Tremor: Treatment F. Vingerhoets (Switzerland) 8.30-10.00 YELLOW HALL 3 ORAL POSTER SESSION (3.50.01-3.50.10) Chairmen: R. Cilia (Italy), I. Isaias (Germany) OP 3.50.01 Case study of sporadic multiple system atrophy at a young age B. Muinjonov, E. Giyazitdinova (Uzbekistan) OP 3.50.02 Vascular parkinsonism as a common manifestation of second stage of CADASIL syndrome B. Muinjonov, E. Giyazitdinova (Uzbekistan) OP 3.50.03 Hyperkinesia in ancient China: perspectives and prescriptions J. Liu, L. Wang (China) OP 3.50.04 Cortical and subcortical neurodegeneration in chorea-acanthocytosis and Huntington’s disease: more differences than similarities J. Liu, H. Heinsen*, T. Arzberger*, B. Bader*, C. Schmitz*, M. Kiessling*, A. Danek* (China, *Germany) OP 3.50.05 Novel GNAL mutation with intra-familial clinical heterogeneity: expanding the phenotype M. Carecchio, C. Panteghini, C. Reale, C. Barzaghi, V. Monti, L. Romito, F. Sasanelli, B. Garavaglia (Italy) OP 3.50.06 DYT16/PRKRA founder mutation causes childhood-onset generalized dystonia in a family from Southern Italy M. Quadri, S. Olgiati, M. Sensi*, F. Gualandi*, E. Groppo*, V. Rispoli*, J. Graafland, G.J. Breedveld, G. Fabbrini*, V. Bonifati (The Netherlands, *Italy) OP 3.50.07 Frequency of the pain and sleep problems at dystonia patients and influence of deep brain stimulation V. Vuletic (Croatia) OP 3.50.08 Tobacco increases dystonia risk but may ameliorate symptoms C. Hellberg, A. Puschmann (Sweden) 34 XXI World Congress on Parkinson’s Disease and Related Disorders OP 3.50.10 Differential induction of dyskinesia and inflammatory responses by intermittent versus continuous L-DOPA delivery in the 6-OHDA model of Parkinson’s disease A.R. Carta, G. Mulas, S. Spiga, D. Lecca E. Pillai (Italy) 10.00 Short break 10.15-11.45 SILVER HALL PLENARY SESSION 3.1 BIOMARKERS IN PARKINSON’S DISEASE Chairmen: N. Hattori (Japan), H. Reichmann (Germany) 10.15 Biomarkers in Parkinson’s disease R. Uitti (USA) 10.45 Plasma and cerebro spinal fluid biomarkers in Parkinson’s disease S. Saiki (Japan) 11.15 In-life diagnostic accuracy C. Adler (USA 11.45 Short break 12.00-13.30 TUESDAY, 8 DECEMBER OP 3.50.09 Wilson disease: acute dystonia during treatment with SSRI or SNRI L. Wictor, K. Wictorin, H. Widner, A. Puschmann (Sweden) EXHIBITION AREA SELECTED TOPIC SESSION (3.60.01-3.60.06) Chairmen: D. Calandrella (Italy), A. Merola (Italy), L. Romito (Italy) OP 3.60.01 PANDA: prolonged release oxycodone/naloxone (OXN PR) for severe Parkinson’s disease (PD)related pain K.R. Chaudhuri, P. Martinez-Martin*, O. Rascol**, M. Lomax, J. Decesare, M. Hopp*** (United Kingdom, *Spain, **France, ***Germany) OP 3.60.02 Chronic subcutaneous infusion therapy with apomorphine in advanced Parkinson’s disease: effects on motor and non motor symptoms with brain metabolism correlations M. Auffret, A. Maurus, M. Vérin, J. Houvenaghel, F. Le Jeune, S. Drapier (France) OP 3.60.03 Clinical and neuropathological features of rapid progressive dementia with lewy bodies A. Geut, D. Hepp, A. Ingrassia, Y. Galis, E. Foncke, A. Lemstra, A. Rozemuller, W. Van De Berg (The Netherlands) OP 3.60.04 Epigenome-wide DNA methylation analysis in brothers and monozygotic twins discordant for Parkinson’s disease O. Kaut, I. Schmitt, S. Witt, J. Tost*, U. Wüllner (Germany, *France) 35 XXI World Congress on Parkinson’s Disease and Related Disorders TUESDAY, 8 DECEMBER OP 3.60.05 Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson’s disease A. Michel, P. Downey, J. Nicolas, D. Scheller (Belgium) OP 3.60.06 Understanding the differential regulation of GBA and GBAP1 expression V. Rimoldi, G. Rovaris, L. Straniero, G. Pezzoli, S. Goldwurm, G. Soldà, R. Asselta, S. Duga (Italy) 12.00-13.30 EXHIBITION AREA POSTER SESSION II (2.037-3.087) 13.45-15.15 SILVER HALL PLENARY SESSION 3.2 DYSTONIA REVISITED Chairmen: M. Hallett (USA), J. Jankovic (USA) 13.45 Dystonia revisited A. Albanese (Italy) 14.15 Pharmacological interventions in dystonia D. Truong (USA) 14.45 Surgical interventions in dystonia J. Volkmann (Germany) 15.15 Short break 15.30-17.00 SILVER HALL CLINICAL PARALLEL SESSION 3.11 NON-MOTOR SYMPTOMS IN MOVEMENT DISORDERS Chairmen: C. Adler (USA), E.D. Louis (USA) 36 15.30 Non-motor symptoms in Parkinson’s disease R. Pfeiffer (USA) 16.00 Non-motor symptoms in essential tremor E.D. Louis (USA) 16.30 Non-motor symptoms in dystonia A. Berardelli (Italy) XXI World Congress on Parkinson’s Disease and Related Disorders RED HALL 2 TRANSLATIONAL PARALLEL SESSION 3.21 NEURODEGENERATION Chairmen: P. Riederer (Germany), M.C. Rodriguez-Oroz (Spain) 15.30 Mitochondrial function A. Schapira (United Kingdom) 16.00 Role of iron H. Reichmann (Germany) 16.30 Role of mitochondrial biogenesis M.B.H. Youdim (Israel) 15.30-17.00 BLUE HALL TUESDAY, 8 DECEMBER 15.30-17.00 INTERACTIVE PARALLEL SESSION 3.31 HANDS ON DYSTONIA: BOTULINUM TOXIN WORKSHOP Coordinator: C. Colosimo (Italy) Speakers: C. Colosimo (Italy), D. Dressler (Germany), D. Truong (USA) 15.30-17.00 RED HALL 1 EDUCATIONAL PARALLEL SESSION 3.41 DYSTONIA Chairman: A. Albanese (Italy) 15.30 Pathophysiology/Classification A. Albanese (Italy) 16.00 Clinical aspects J. Jankovic (USA) 16.30 Surgical interventions A. Fasano (Canada) 17.00 Short break 37 XXI World Congress on Parkinson’s Disease and Related Disorders TUESDAY, 8 DECEMBER 17.15-18.45 SILVER HALL CLINICAL PARALLEL SESSION 3.12 DEEP BRAIN STIMULATION Chairmen: M.F. Contarino (The Netherlands), A. Fasano (Canada) 17.15 Indications of deep brain stimulation E. Moro (France) 17.45 Sensing technology: rationale P. Brown (United Kingdom) 18.15 Adaptive deep brain stimulation: state of the art and where are we heading to A. Priori (Italy) 17.15-18.45 BLUE HALL INTERACTIVE PARALLEL SESSION 3.32 ANIMAL MODELS IN MOVEMENT DISORDERS Chairmen: A.M. Cenci Nilsson (Sweden), M.B.H. Youdim (Israel) 17.15 Animal models of neurodegeneration in Parkinson’s disease F. Blandini (Italy) 17.45 Symptomatic models of motor- and non-motor features in Parkinson’s disease A.M. Cenci Nilsson (Sweden) 18.15 Huntington animal model S.M. Hersch (USA) 17.15-18.45 EDUCATIONAL PARALLEL SESSION 3.42 DIAGNOSTIC CHALLENGES Chairman: G.K. Wenning (Austria) 38 17.15 Multiple system atrophy vs Parkinson’s disease G.K. Wenning (Austria) 17.45 Progressive supranuclear palsy subtypes M. Stamelou (Greece) 18.15 Cortico basal degeneration and cortico basal syndrome C. Colosimo (Italy) RED HALL 1 XXI World Congress on Parkinson’s Disease and Related Disorders YELLOW HALL 3 ORAL POSTER SESSION (3.50.11-3.50.22) Chairmen: D. Calandrella (Italy), A. Merola (Italy), L. Romito (Italy) OP 3.50.11 Interoceptive awareness in patients with functional motor disorders B. Demartini, L. Ricciardi*, L. Crucianelli*, C. Krahé*, M.J. Edwards*, A. Photopoulou* (Italy, *United Kingdom) OP 3.50.12 Center of pressure velocity and its fast alternating deviations as an objective measure of balance – normal values and their sensitivity investigated in SCA patients A. Sobanska, M. Rakowicz, L. Czerwosz, A. Sulek, I. Stepniak, R. Rola (Poland) OP 3.50.13 Clinical profile of hundred patients with Ataxia Telangiectasia from India M. Mahadevappa, D.V. Santhosh, M. Netravathi, R. Yadav, P.K. Pal (India) OP 3.50.14 Altered functional topography of the striatum in resting state FMRI in Parkinson’s disease S.N. Tan, Y. Zhang, A. Liu, J. Wang, M.J. Mckeown (Canada) TUESDAY, 8 DECEMBER 17.15-18.45 OP 3.50.15 Is the mechanism of nervous cells death in Parkinson different than in other neurodegenerations - arguments from MRI study? A. Friedman, R. Kulinski, J. Galazka-Friedman (Poland) OP 3.50.16 Putaminal diffusivity changes correlates with motor progression in Parkinson’s disease on 6-year follow-up L.L. Chan, K.M. Ng, C.S. Yeoh, H.H. Li, H. Rumpel, E.K. Tan (Singapore) OP 3.50.17 Fatigue in Parkinson’s disease and striatum dopamine transporter scan (DaTscan) uptake A. Sauerbier, P. Martinez-Martin*, M. Politis, A. Rizos, N. Trojanovic, N. Mulholland, G. Vivian, B. Corcoran, D. Trivedi, L. Perkins, R. Inniss, T. Chiwera, R. Barreto, M. Parry, A. Martin, N. Dimitrov, R. Brown, K. Ray Chaudhuri (United Kingdom, *Spain) OP 3.50.18 The MIBG scintigraphy and DAT SPECT contribute to the diagnosis of PD and other related disorders, and evaluations of the course and stage of PD S. Tada, R. Ando, H. Iwaki, T. Tsujii, Y. Yabe, N. Nishikawa, M. Nagai, M. Nomoto (Japan) OP 3.50.19 Characteristic metabolic brain pattern in Slovenian Parkinson’s disease patients P. Tomse, R. Tomaz, Z. Pirtošek , Y. Ma*, D. Eidelberg*, M. Trost (Slovenia, *USA) OP 3.50.20 Updated long-term safety from ongoing phase 3 trials of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease R. Rodriguez, N. Schmulewitz, D. Stein, W. Robieson, C. Hall, S. Eaton, K. Chatamra, J. Benesh, A. Espay (USA) OP 3.50.21 Opioid K receptor variant delays the onset of dyskinesias in Parkinson’s disease R. Cilia, R. Asselta, R. Benfante, E. Cereda, D. Vallauri, L.Marabini, D. Fornasari, S. Goldwurm, G. Pezzoli (Italy) OP 3.50.22 Motor effects of phosphodiesterase 9 inhibition in the non-human primate model of Parkinson’s disease G. Masilamoni, A. Singh, X. Tang, A. McRiner, L. Leventhal, S. Papa (USA) 39 XXI World Congress on Parkinson’s Disease and Related Disorders WEDNESDAY, 9 DECEMBER 8.30-10.00 SILVER HALL CLINICAL PARALLEL SESSION 4.10 MOVEMENT DISORDERS DEVELOPMENTS 2014-2015: BEST PARKINSON RELATED DISEASES ARTICLES Chairmen: S.M. Calne (Canada), R. Pfeiffer (USA), Z.K. Wszolek (USA) R. Rodnitzky (USA) J.H. Friedman (USA) 8.30-10.00 RED HALL 2 TRANSLATIONAL PARALLEL SESSION 4.20 SENSOR AND SLEEP DEFICITS IN PARKINSON’S DISEASE Chairmen: A. Antonini (Italy), P. Riederer (Germany) 8.30 Vision I. Bodis-Wollner (USA) 9.00 Auditory C. Vitale (Italy) 9.30 Sleep R. Bhidayasiri (Thailand) 8.30-10.00 RED HALL 1 EDUCATIONAL PARALLEL SESSION 4.40 DIAGNOSIS OF UNCOMMON MOVEMENT DISORDERS Chairman: V.S. Kostic (Serbia and Montenegro) 40 8.30 Myoclonus V.S. Kostic (Serbia and Montenegro) 9.00 Chorea and tics J. Roth (Czech Republic) 9.30 Cerebellar syndromes A. Dürr (France) XXI World Congress on Parkinson’s Disease and Related Disorders YELLOW HALL 3 ORAL POSTER SESSION (4.50.01-4.50.12) Chairman: P. Martinez-Martin (Spain) OP 4.50.01 Synaptic homeostasis in Parkinson’s disease: an high-density EEG study in different stage of the disease V. Trendafilov, S. Sarasso*, J. Moeller, C. Staedler, A. Kaelin-Lang, S. Galati (Switzerland, *Italy) OP 4.50.02 Brain network changes in relation to beginning apathy in PD patients F. Hatz, A. Meyer, U. Gschwandtner, P. Fuhr (Switzerland) OP 4.50.03 Functional connectivity underpinnings of fatigue in “drug-naïve” patients with Parkinson’s disease A. Giordano, A. Tessitore, R. De Micco, G. Caiazzo, A. Russo, M. Cirillo, F. Esposito, G. Tedeschi (Italy) OP 4.50.04 Correlation of the EEG frequency with cognitive performance in Parkinson’s disease - six-months follow-up V. Cozac, M. Chaturvedi, F. Hatz, A. Meyer, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) OP 4.50.05 Alertness as assessed by clinical testing and alpha reactivity does not correlate with executive function decline in Parkinson’s disease (PD) R. Sturzenegger, A. Meyer, M. Chaturvedi, V. Cozac, F. Hatz, U. Gschwandtner, P. Fuhr (Switzerland) WEDNESDAY, 9 DECEMBER 8.30-10.00 OP 4.50.06 EEG features of dyskinesias, complicated by levodopa therapy in patient with parkinson’s disease U. Askhonov, B. Gafurov, G. Ashanov (Uzbekistan) OP 4.50.07 Electromyographic diagnostics of Parkinson’s disease and detection risk groups among relatives of patients D. Ayupova (Uzbekistan) OP 4.50.08 Identification of the globus pallidus interna based on time patterns analysis in Parkinson’s disease D.S. Andres, C. Daniel*, M. Merello* (Switzerland, *Argentina) OP 4.50.09 Identification of novel PD genes by whole-exome sequencing in Italian families L. Straniero, G. Soldà, R. Asselta, I. Guella*, G. Pezzoli, M. Farrer*, S. Goldwurm, S. Duga (Italy, *Canada) OP 4.50.10 DNAJC6 mutations associated with early-onset Parkinson’s disease S. Olgiati, M. Quadri, M. Fang, J.P. Rood, J.A. Saute*, H.F. Chien*, C.G. Bouwkamp, J. Graafland, M. Minneboo, G.J. Breedveld, J. Zhang***, F.W. Verheijen, W. Mandemakers, A.J. Boon, A.J. Kievit, L.B. Jardim*, E.R. Barbosa*, C.R. Rieder*, K.L. Leenders, J. Wang**, V. Bonifati (The Netherlands, *Brazil, **China) OP 4.50.12 Defective glucocerebrosidase in GBA1 mutant Parkinson’s disease fibroblasts is rescued by chemical chaperone ambroxol through modulation of lysosomal factors G. Ambrosi, C. Ghezzi, R. Zangaglia, G. Levandis, C. Pacchetti, F. Blandini (Italy) 10.00 Short break 41 XXI World Congress on Parkinson’s Disease and Related Disorders WEDNESDAY, 9 DECEMBER 10.15-11.45 SILVER HALL PLENARY SESSION 4.1 COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE Chairmen: P. Barone (Italy), A.J. Stoessl (Canada) 10.15 Mild cognitive impairment J. Kulisevsky (Spain) 10.45 Disrupted functional connectivity and other markers of cognitive decline in Parkinson’s Disease O. Monchi (Canada) 11.15 Parkinson’s disease dementia and dementia with Lewy bodies D. Aarsland (Sweden) 11.45-13.15 SILVER HALL PLENARY SESSION 4.2 PSYCHOGENIC MOVEMENT DISORDERS Chairmen: K. Bhatia (United Kingdom), M. Hallett (USA) 11.45 Epidemiology and pathophysiology of psychogenic movement disorders M. Edwards (United Kingdom) 12.15 Clinical presentations M. Hallett (USA) 12.45 Electrophysiological evaluation P. Pal (India) 13.15-13.45 POSTER SESSION III (3.088-6.070) 42 EXHIBITION AREA XXI World Congress on Parkinson’s Disease and Related Disorders SILVER HALL CLINICAL PARALLEL SESSION 4.11 DISEASE ASSOCIATIONS IN MOVEMENT DISORDERS: CONTROVERSIES Chairmen: U. Bonuccelli (Italy), P. Martinez Martin (Spain), M. Onofrj (Italy) 13.45 Alzheimer’s disease and Parkinson’s disease A. Korczyn (Israel) 14.15 Essential tremor and Parkinson’s disease J. Jankovic (USA) 14.45 Vascular parkinsonism and Parkinson’s disease I. Rektor (Czech Republic) 13.45-15.15 RED HALL 2 WEDNESDAY, 9 DECEMBER 13.45-15.15 TRANSLATIONAL PARALLEL SESSION 4.21 RECENT ADVANCES IN ESSENTIAL TREMOR Chairmen: E.D. Louis (USA), J. Volkmann (Germany) 13.45 Refining diagnostic criteria M. Edwards (United Kingdom) 14.15 Genetics E.K. Tan (Singapore) 14.45 Surgical treatment A. Fasano (Canada) 13.45-15.15 RED HALL 1 EDUCATIONAL PARALLEL SESSION 4.41 INSTRUMENTAL HALLMARKS OF PARKINSONISM Chairman: R. Ceravolo (Italy) 13.45 Neuropathology W.D.J. van de Berg (The Netherlands) 14.15 Magnetic resonance imaging A. Tessitore (Italy) 14.45 Position Emission Tomography/Single-Photon Emission Computed Tomography R. Ceravolo (Italy) 43 XXI World Congress on Parkinson’s Disease and Related Disorders WEDNESDAY, 9 DECEMBER 13.45-15.15 YELLOW HALL 3 ORAL POSTER SESSION (4.50.13-4.50.23) Chairman: A. Antonini (Italy) OP 4.50.13 Caffeine intake and genetic susceptibility to Parkinson’s disease P. Sharan, E.K. Tan (Singapore) OP 4.50.15 Ameliorative effects of 1,3,4-thiadiazole derivatives on scopolamine induced cognitive deficits in mice A. Kulshreshtha, P. Piplani (India) OP 4.50.16 c-Rel deficient mice, a mouse model of “spreading” PD-like pathology E. Parrella, A. Bellucci, V. Porrini, A. Lanzillotta, M. Benarese, G. Vegezzi, C. Baiguera, A. Antonini, P.F. Spano, M. Pizzi (Italy) OP 4.50.17 Integration of cortical and basal ganglia inputs in motor thalamus of parkinsonian animal models G. Orban, W. Song, A. Kaelin-Lang, S. Galati (Switzerland) OP 4.50.20 Role of dopaminergic receptors and post synaptic signaling in arsenic induced neurotoxicity: ameliorative effect of curcumin P. Srivastava, Y. Dhuriya, R. Gupta, R. Shukla, A.B. Pant, V.K. Khanna (India) OP 4.50.21 Antiparkinson and antioxidant effect of pyridylpyrazolinyl substituted heterosteroids in LPS induced neuroinflammation model of neurodegenerative disorders R. Singh, R. Bansal (India) OP 4.50.22 Inhibition of PERK and NFKB pathway can reduce death of stressed dopaminergic neurons differentiated from human stem cell line Z.L. Chaudhry, B. Ahmed (United Kingdom) OP 4.50.23 Oral intake of anti-hangover substance increases aldehyde dehydrogenase activity: new preventive and therapeutic potentials for oxidative neuronal injury? C. Bang, B. Kang, S. Choung, K. Choi (South Korea) 15.15-15.30 PLENARY SESSION CLOSING CEREMONY 44 SILVER HALL XXI World Congress on Parkinson’s Disease and Related Disorders P 1.001 The study of the prevalence of Parkinson disease K. Karbozova (Kyrgyzstan) P 1.002 Sex differences in Parkinson’s disease U. Fiszer, M. Michałowska, T. Szatanowski (Poland) P 1.003 An unexpected higher prevalence of Parkinson’s disease in females than males in the province of Trento (Italy): a clues for the etiopathogenesis? M.C. Malaguti, N. Vanacore, S. Ferrari, S. Piffer, R. Pertile, R. Roni, A. Polverino, M. Gentilini, F. Cembrani, V. Bertozzi, M. Pellegrini, D. Orrico (Italy) P 1.004 Parkinson’s disease in Senegal: epidemiologic, clinical and therapeutic aspects N.M. Gaye, L.B. Seck, N.S. Diagne, A.D. Sow, A.M. Diop, O. Cisse, A.B. Faye, M.S. Diop, K. Toure, M. Ndiaye, A.G. Diop, M.M. Ndiaye (Senegal) P 1.006 Birth month and Parkinson’s disease: Is there any relationship? R. Kurisaki, H. Hori, K. Nakahara, A. Kuratomi, Y. Nishida, K. Uekawa (Japan) P 1.008 A step forward to the future: UPDRS kinematic measures for telemedicine G. Albani, C. Azzaro, F. Parisi, C. Ferraris, M. Giuberti, L. Contin, D. Pianu, L.G. Pradotto, V. Cimolin, M. Galli, R. Nerino, G. Ferrari, A. Mauro (Italy) P 1.009 Occupational exposure to Organic solvents and welding fumes and risk of Parkinson’s disease K. Kovendan, R. Chandirasekar, K. Murugan, S. Vincent (India) P 1.011 An explorative assessment of antioxidant and inflammatory biomarkers for identification of prodromal Parkinson’s disease (PD) J. Campolo, R. De Maria, L. Cozzi, M. Parolini, P. Proserpio, L. Nobili, G. Gelosa, I. Piccolo, P. Marraccini (Italy) P 1.012 Urinary biomarkers of oxidative stress in early Parkinson’s disease S. Calzetti, R. Andreoli, A. Negrotti, G. De Palma, E. Marchesi, S. Riccardi, A. Mutti (Italy) P 1.013 A comparative study of oxidative stress markers between the tremor dominant and akinetic-rigid subtypes of patients with Parkinson’s disease R. Naduthota, R. Christopher, R. Yadav, P.K. Pal (India) P 1.014 The relationship between serum and cerebrospinal fluid inflammatory biomarkers in Parkinson’s disease I. Miliukhina, A. Kudrevatykh, E. Gracheva, M. Karpenko (Russia) P 1.015 Level of S100B protein in blood plasma depending on the form Parkinson’s disease M. Juraev, R. Matmurodov, K. Khalimova (Uzbekistan) P 1.016 Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in PD M. Hirayama, S. Hasegawa, T. Minato, T. Asahara, K. Nomoto, H. Tsuji, A. Okamoto, K. Ohno (Japan) P 1.017 Changes in serum level of interferon-gamma, alpha tumor necrosis factor and autoantibodies in Parkinson’s disease E. Giyazitdinova, G. Rakhimbayeva, Y. Musayeva, B. Muinjonov (Uzbekistan) POSTER SESSION 1 - MONDAY, 7 DECEMBER POSTER SESSION 1 (1.001-2.036) 45 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 1 - MONDAY, 7 DECEMBER 46 P 1.018 Blood lipid parameters in patients with Parkinson’s disease E. Giyazitdinova, B. Muinjonov, G. Rakhimbayeva, Y. Musayeva (Uzbekistan) P 1.019 CSF levels of heart fatty acid binding protein in Parkinson’s and Alzheimer’s disease D. Chiasserini, L. Biscetti, P. Eusebi, L. Farotti, N. Tambasco, P. Calabresi, L. Parnetti (Italy) P 1.020 Cancer comorbidity among Parkinson’s Disease patients ; a population based large-scale cohort study R. Gurel, N. Giladi, V. Rosani, T. Gurevich, B. El-Ad, B. Hemo, J. Tzamir, C. Peretz (Israel) P 1.021 Association between cancers and risk of Parkinson disease: a cohort study R. Piri, M. Naghavi-Behzad (Iran) P 1.022 Risk of cancer among patients with Parkinson disease M. Naghavi-Behzad, R. Piri (Iran) P 1.023 Cancer in Parkinson’s disease P. Tacik, S. Curry, A. Strongosky, S. Fujioka, M. Heckman, Z.K. Wszolek (USA) P 1.024 Intraventricular tumour presenting as progressive supranuclear palsy-like phenotype M. Morelli, F. Fera, F. Bono, A. Fratto, G. Arabia, A. Quattrone (Italy) P 1.025 A case of premenstrual tremor S. Khachaturyan, K. Harutyunyan, A. Voskanyan, G. Avagyan, H. Amirjanyan, I. Gabrielyan, M. Hovhannes* (Armenia) P 1.026 Motor and cognitive deterioration in advanced young-onset PD: a cautionary tale N. Zupancic Kriznar, B. Meglic, M. Trost, M. Kramberger Gregoric, L. Ocepek, R. Rajnar, Z. Pirtošek (Slovenia) P 1.027 Progression of Parkinson’s disease during the 5-year follow-up M. Petrovic, E. Stefanova, T. Stojkovic, V. Kostic (Serbia) P 1.028 Changes of resting state EEG in patients with left-sided and right-sided Parkinson’s disease N. Kozhemiako, S. Kryzhanovskyi, A. Cherninskyi, I. Karaban, N. Karasevich (Ukraine) P 1.029 Evaluation of serum amino acid profile in patients with advanced Parkinson’s disease M. Figura, K. Kusmierska, E. Bucior, S. Szlufik, D. Koziorowski, Z. Jamrozik, A. Friedman, P. Janik (Poland) P 1.030 Hospitalisation in early Parkinson’s disease using Hospital Episodes Statistics from the PD MED trial S. Muzerengi, R. Woolley, C. Rick, N. Ives, R. Gray, F. Dowling, C.E. Clarke (United Kingdom) P 1.031 Hospitalisation coding errors in Parkinson’s disease in a large UK teaching hospital S. Muzerengi, C. Rick, I. Begaj, N. Ives, F. Evison, R. Woolley, C.E. Clarke (United Kingdom) P 1.032 Hospital-based study on emergency admission in patients with Parkinson’s disease S. Fujioka, J. Fukae, H. Ogura, T. Mishima, S. Yanamoto, M. Higuchi, G. Umemoto, Y. Tsuboi (Japan) P 1.033 Usefulness of Parkinson’s KinetiGraph in a Parkinson’s disease clinic - Survey of 82 patients L. Klingelhoefer, A. Rizos*, A. Sauerbier*, D. Trivedi*, R. Inniss*, L. Perkins*, H. Reichmann*, K.R. Chaudhuri* (Germany, *United Kingdom) XXI World Congress on Parkinson’s Disease and Related Disorders Premotor symptoms as predictors of outcome in Parkinson’s disease: a nationwide populationbased and case-control study M. Chang (Taiwan) P 1.036 Non motor symptoms impact quality of life (QOL) in de novo Parkinson’s disease (PD) C. Toyoda, T. Umehara, H. Matsuno, H. Oka (Japan) P 1.037 Clinical manifestations at stage de novo of Parkinson disease in the neurological clinic of Fann National Teaching Hospital O. Cisse, A.M. Basse, E.H.M. Ba, S.M.L. Dadah, N.M. Gaye, M.A. Diop, F.Y. Fogang, A.D. Sow, M.S. Diop, A. Diatta, M. Ndiaye, A.G. Diop, M.M. Ndiaye (Senegal) P 1.038 Assessing the non-motor symptom burden progression in a longitudinal study of 411 Parkinson’s patients, using the non-motor symptom questionnaire M. Grilo, D. Trivedi, E. Moti, R. Barreto, A. Sauerbier, A. Rizos, L. Perkins, R. Inniss, T. Chiwera, K.R. Chaudhuri (United Kingdom) P 1039 Quality of life in patients with Parkinson’s Disease in Uzbekistan N. Tolibova, M. Khanova, O. Turgunkhujaev (Uzbekistan) P 1.040 Validation of the Italian Non Motor Symptoms Questionnaire and Non Motor Symptoms Scale for Parkinson’s disease I. Cova, N. Vanacore, P. Contri, G. Meco, S. Pomati, G. Grande, E. Lacorte, A. Priori, C. Mariani (Italy) P 1.041 Parkinson’s disease non-motor profile and MAPT haplotypes M.E. Di Battista, A. Rubino, C. Papi, M. Valente, E. Pascale, C. Purcaro, G. Meco (Italy) P 1.042 Sleep and mood predict quality of life change in Parkinson’s disease: a longitudinal study K.M. Prakash, N. Nadkarni, W. Lye, M. Yong, E. Tan (Singapore) P 1.043 Frequency and sleep stage sequence of SOREM periods in Parkinson’s disease T. Murer, E. Werth, R. Poryazova, Y. Gavrilov, D. Waldvogel, C. Baumann, P. Valko (Switzerland) P 1.044 REM sleep behavior disorder and cognitive functions in Parkinson’s disease E. Lyashenko, O. Levin, M. Poluektov (Russia) P 1.045 REM Sleep Behavior Disorder (RBD) as a predictor of development of daytime hypersomnia and nocturia in Parkinson’s disease (PD) M. Nodel, N. Yakhno, J. Ukraintseva (Russia) P 1.046 Sleep and motor symptoms in Parkinson’s disease with REM sleep behavior disorder: a preliminary study K.H. Park, C. Kim, Y. Sung (South Korea) P 1.047 Insomnia in Parkinson’s disease B. Muinjonov, E. Giyazitdinova (Uzbekistan) P 1.048 Association between daytime sleepiness and the cholinergic ascending reticular activating system in Parkinson’s disease M. Iijima, M. Osawa, K. Kitagawa (Japan) P 1.049 The painful dimension of Parkinson’s disease – relation between pain, depression and sleep N. Horia, I. Serbanoiu, C. Panea (Romania) POSTER SESSION 1 - MONDAY, 7 DECEMBER P 1.034 47 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 1 - MONDAY, 7 DECEMBER 48 P 1.050 The first Parkinson’s Disease Pain Questionnaire (King’s PD Pain Quest) – An interim analysis of a multicentre study of the patient’s perspective A. Rizos, P. Martinez-Martin*, S. Pal, C. Carroll, D. Martino, R. Sophia, C. Falup-Pecurariu**, B. Kessel, A. Sauerbier, A. Martin, M. Parry, R. Inniss, L. Parkins, D. Trivedi, T. Chiwera, P. Odin***, A. Antonini****, K.R. Chaudhuri (United Kingdom, *Spain, **Romania, ***Sweden, ****Italy) P 1.051 ON-OFF fluctuations predict the re-emergence of fatigue in Parkinson’s disease T. Tamburini, D. Massucco, G. Abbruzzese (Italy) P 1.052 Visuospatial, visuoconstructive and visuoperceptive functioning in patients with Parkinson`s disease M. Rodriguez-Violante, G. Arciniega-Martinez, A. Jorge De Sarachaga, Y. Rodriguez-Agudelo, A. Cervantes-Arriaga, M. Chavez-Oliveros (Mexico) P 1.054 The importance of Ishihara Testing in early diagnosing of Parkinson’s disease S. Mirdedaev (Uzbekistan) P 1.055 Somatization factor in Parkinson’s disease: a preliminary study L. Bonanni, D. Carrozzini*, M. Fulchieri, M. Onofrj, S. Delli Pizzi, A. Thomas (Italy, *Denmark) P 1.056 Autonomic disorders in Parkinson’s disease J. Toshev, N. Nurmetov, O. Kurbanov, Z. Ibodullaev (Uzbekistan) P 1.057 The ability of autonomic function tests to detect the possible deterioration of autonomic system in PD patients - Preliminary results A. Strasz, W. Niewiadomski, A. Gasiorowska, A. Karbowniczek, M. Zylinski, M. Skupinska, G. Cybulski, E. Palasz, G. Niewiadomska (Poland) P 1.058 Autonomic dysfunction in Parkinson’s disease associated with common glucocerebrosidase gene mutations F. Del Sorbo, A.E. Elia, L.M. Romito, P. Soliveri, C. Barzaghi, B. Garavaglia, P. Cortelli, A. Albanese (Italy) P 1.059 Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder S.H. Lee, J.S. Kim (South Korea) P 1.060 Longer duration of Parkinson’s disease is associated with reduced prevalence of hypertension V. Brandi, D. Vetrano, M.S. Pisciotta, M.R. Lo Monaco, A. Laudisio, G. Onder, R. Bernabei, G. Zuccalà (Italy) P 1.061 Clinical course of migraine in Parkinson patients M. Lotfinia (Iran) P 1.062 Vegetative nervous system status according to cardiointervalogram data of ethnic Kyrgyz people with Parkinson disease N. Chekeeva (Kyrgyzstan) XXI World Congress on Parkinson’s Disease and Related Disorders Cardiac sympathetic denervation predicts levodopa-induced dyskinesia in patients with Parkinson’s disease S. Kang, J.Y. Ahn, H. Kim (South Korea) P 1.064 Structural and functional myocardial abnormalities in patients with Parkinson’s disease compared with control group: an echocardiography study A. Gonzalez-Martinez, A. Lopez-Garcia, J. Piqueras-Flores, A. Moreno-Reig, J. Vaamonde-Gamo (Spain) P 1.065 Relationship S100 Protein levels in blood plasma with a frequency of occurrence of cardiovascular complications Parkinson’s disease M. Juraev, R. Matmurodov, K. Khalimova (Uzbekistan) P 1.067 Colonic volume and gastrointestinal symptoms in Parkinson’s disease K. Knudsen, T. Fedorova, P. Borghammer (Denmark) P 1.068 Gastroesophageal dysmotility in advanced Parkinson’s disease F. Mancini, L. Manfredi, M. Lacerenza, C. Colombo, A. Bestetti (Italy) P 1.069 Alpha-synuclein immunohistochemistry studies of gastrointestinal tissue from patients with prodromal Parkinson’s disease M. Gersel Stokholm, S.J. Hamilton-Dutoit, E.H. Danielsen, P. Borghammer (Denmark) P 1.071 What can go wrong? Sexual dysfunction in Parkinson’s disease I. Serbanoiu, H. Nicolae, C. Panea (Romania) P 1.072 Pulmonary function and clinical characteristics of Parkinson’s disease S. Cheon, M. Park, J.W. Kin (South Korea) P 1.073 Character of respiratory disorders in Parkinson’s disease J. Toshev, N. Nurmetov, O. Nurmetov, Z. Ibodullaev (Uzbekistan) P 1.074 Dysphagia, pneumonia and hospital admissions in Parkinson’s Disease: a multicentre observational study E. Moti, K. Lauckaite*, R. Barreto, C. Bitsara, M. Grilo, S. Diaconu**, T. Chiwera, A. Rizos, J. Johnson, S. Bostantjopoulou***, C. Falup-Pecurariu***, K. Ray Chaudhuri (United Kingdom, *Lithuania, **Romania, ***Greece) P 1.075 Speech disorders and Parkinson’s disease M. Pettorino, E. Pellegrino, M.G. Busà (Italy) P 1.076 Positional nystagmus from BPPV in polysomnography of PD patients E. Werth, C. Baumann, D. Straumann, P. Valko, K. Weber, Y. Valko (Switzerland) P 1.077 An alternative perspective on interpretation of the secondary motor symptoms of Parkinson’s disease L. Vucolova (USA) P 1.078 An alternative perspective on interpretation of the cardinal motor symptoms of Parkinson’s disease L. Vucolova (USA) P 1.079 Prevalence of anxiety in Parkinson’s disease K. Mengesha (Ethiopia) POSTER SESSION 1 - MONDAY, 7 DECEMBER P 1.063 49 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 1 - MONDAY, 7 DECEMBER 50 P 1.080 Can arm swing be clinical predictors of postural instability in Parkinson’s disease? W. Buated, P. Lolekha*, S. Hidaka, N. Kashyap, T. Fujinami (Japan, *Thailand) P 1.081 Clinical predictors of postural instability in Parkinson’s disease: the Nintendo Wii Balance Board Posturographic Study P. Lolekha, W. Buated*, S. Hidaka*, N. Kashyap*, T. Fujinami* (Thailand, * Japan) P 1.082 Postural instability detected by stabiloplatform examination in the patients with vascular mild cognitive impairment and Parkinson’s disease patients with mild cognitive impairment I. Miliukhina, T. Sergeev, A. Kudrevatykh, E. Gracheva, M. Didour (Russia) P 1.083 Clinical and objective evaluation of turning in floor squares of various sizes in patients with Parkinson’s disease and healthy controls L. Stuhlinger, U. Fietzek, A. Plate, C. Hamann, K. Bötzel, A. Ceballos-Baumann (Germany) P 1.084 Posturography evaluation and balance tests as potential markers of assessment of postural disability progression in Parkinson’s disease patients after DBS STN implantation S. Szlufik, M. Kloda, D. Koziorowski, I. Potrzebowska, J. Dutkiewicz, K. Gregier, T. Mandat, A. Friedman (Poland) P 1.085 Postural sensory correlates of gait freezing in Parkinson’s disease Y.E. Huh, J. Youn, Y.S. Kim, M. Hwang, J.W. Cho (South Korea) P 1.086 Alterations in the dynamic balance level in elderly with Parkinson´s disease B. Mendez-Rial, J.M. Cancela Carral, C. Ayan, M.H. Vila (Spain) P 1.087 Evaluation of spatiotemporal parameters in Parkinson’s disease and their correlation with UPDRS motor score about 32 cases D. Kadi, N. Ababou, S. Daoudi, M. Aderkichi (Algeria) P 1.088 Using the “StartReact” paradigm to investigate postural instability in Parkinson’s disease J. Tan, T. Perera, J. Mcginley, W. Thevathasan (Australia) P 1.089 Timed up and Go and its application in older adults with Parkinson’s disease. Systematic review I. Mollinedo-Cardalda, J.M. Cancela Carral, G. Rodriguez-Fuentes (Spain) P 1.090 Factors influencing the falls in patients with Parkinson`s disease N. Skripkina, O. Levin (Russia) P 1.091 Falling direction is important predictors for mechanism of falls in patients with Parkinson’s disease J. Youn, M. Hwang, D. Kim, J.W. Cho (South Korea) P 1.092 Frequency and risk of falls in Parkinson’s disease in Ibadan T. Farombi, M. Owolabi, A. Ogunniyi (Nigeria) P 1.093 Falls in Parkinson’s disease: effects on health related quality of life T. Farombi, J. Yaria, M. Owolabi, A. Ogunniyi (Nigeria) P 1.094 A prospective study of cumulative incidence and course of RLS in de novo PD patients during chronic dopaminergic therapy S. Calzetti, E. Marchesi, M. Goldoni, A. Negrotti (Italy) XXI World Congress on Parkinson’s Disease and Related Disorders Semantic and phonemic verbal fluency in patients with Parkinson’s disease (PD) A.D. Roesch, A. Meyer, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) P 1.096 Facial emotion recognition in Parkinson’s disease S. Kalampokini, E. Lyros, M. Luley, J. Spiegel, M. Unger (Germany) P 1.097 Emotion recognition and emotion expression in Parkinson’s disease: an unifying emotional mirror mechanism? L. Ricciardi, F. Visco-Comandini, R. Erro, F. Morgante*, M. Bologna*, A. Fasano**, D. Ricciardi*, M. Edwards, J. Kilner (United Kingdom, *Italy, **Toronto - Canada) P 1.098 Mentally and emotional disorders of Parkinson’s disease K. Khasanova (Uzbekistan) P 1.099 Behavioral and psychological symptoms in Korean patients with early Parkinson’s disease J. Ahn, H. Kim, J. Heo (South Korea) P 1.100 Prevalence of depression in Parkinson’s disease patients A.M. Woldehana (Ethiopia) P 1.101 Prevalence of depression and dementia in Parkinson’s disease F. Yunusov, G. Rakhimbaeva (Uzbekistan) P 1.102 Clinical correlates of depression and anxiety in patients with Parkinson’s disease H. Hambardzumyan, H. Manvelyan (Armenia) P 1.103 Suicidal ideation in Parkinson’s disease M.M. Dumitru (Romania) P 1.104 Is there any relationship between olfactory dysfunction and depression in Parkinson’s disease? K. Hasegawa, H. Onuma, S. Nakamura, A. Kumon, E. Horiuchi (Japan) P 1.105 Association of depressive symptoms with circadian blood pressure alterations in Parkinson’s disease M.S. Pisciotta, D.L. Vetrano, V. Brandi, M.R. Lo Monaco, A. Laudisio, D. Fusco, G. Onder, R. Bernabei, G. Zuccalà (Italy) P 1.106 Vascular risk factors and depressive symptoms in Parkinson’s disease dementia M.H. Park, J.Y. Min (South Korea) P 1.107 Clinical impact of mood disorders on non-motor symptoms in Parkinson’s disease T. Shinoda, T. Maeda (Japan) P 1.108 Parkinson’s disease and cognitive reserve S. Guzzetti, A. Caporali, F. Mancini, L. Manfredi, R. Daini, A. Antonini (Italy) P 1.109 Is cognitive function influenced to the self-assessment about the psychological symptom in PD? A. Kumon, Y. Kobayashi, M. Saruwatari, N. Kawashima, K. Hasegawa (Japan) P 1.110 Theory of the mind in subjects with Parkinson´s disease: a case-control study G.G. Arciniega-Martinez, A. Jorge De Sarachaga, J.E. Simancas-Ruiz, M.S. Escobar-Barrios, E.E. Carreon-Bautista, L.F. Balboa-Alegría, A. Cervantes-Arriaga, M. Rodriguez-Violante (Mexico) POSTER SESSION 1 - MONDAY, 7 DECEMBER P 1.095 51 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 1 - MONDAY, 7 DECEMBER 52 P 1.111 The heterogeneity of cognitive impairments in Parkinson’s disease L. Alonso Recio, P. Martín Plasencia, J.M. Serrano Rodríguez (Spain) P 1.112 Cognitive profile in non-demented GBA-carriers Parkinson’s disease patients C. Siri, E. Reali, B. Pozzi, A. Colombo, R. Cilia, M. Canesi, C.B. Mariani, N. Meucci, G. Sacilotto, S. Tesei, A.L. Zecchinelli, M. Zini, G. Pezzoli, S. Goldwurm (Milan) P 1.113 Description of cognitive disorders of Alzheimer’s disease and Parkinson’s disease D. Tolibov, G. Rakhimbaeva (Uzbekistan) P 1.114 Cognitive disorders in Parkinsonism S. Karakhonova, G. Ishanhodjaeva (Uzbekistan) P 1.115 Cognitive impairment in Parkinson’s disease is associated with reduced cerebrovascular reactivity A. Rubino, T. Romeo, M.E. Di Battista, M. Valente, C. Papi, P. Giacomini, G. Meco (Italy) P 1.116 MoCA vs. MMSE sensitivity as screening instruments of cognitive impairment in PD, MSA and PSP patients E. Fiorenzato, L. Weis, C. Falup-Pecurariu*, A. Antonini, R. Biundo (Italy, *Romania) P 1.117 Blood biomarkers associated with cognitive decline in early stage and drug-naive Parkinson’s disease patients J. Santiago, J. Potashkin (USA) P 1.118 Visual Hallucination Inventory (VHI) and NMS Questionnaire (NMSQ) in identification and characterisation of visual hallucinations (VH) in elderly patients with Parkinson’s disease (PD) S. Gangadharan, G. Padmakumar, M. Rees, A. Johnson, A. Withanage, C.P. Padmakumar (Australia) P 1.119 Impact of gender on impulse control disorders and other non-motor symptoms among Parkinson’s disease patients N. Kovács, G. Deli, Z. Aschermann, A. Makkos, J. Janszky, M. Kovács (Hungary) P 1.120 Pathological gambling in Parkinson’s disease patients: dopaminergic medication or personality traits fault? L. Brusa, V. Pavino, R. Ceravolo, M.C. Massimetti, A. Stefani, P. Stanzione (Italy) P 1.121 Impulsive-compulsive behaviors in Parkin-associated Parkinson’s disease: a case-control study F. Morgante, A. Fasano*, M. Ginevrino, S. Petrucci, L. Ricciardi**, F. Bove, C. Criscuolo, M. Moccia, A.R. Bentivoglio, M.T. Pellecchia, G. Di Michele**, P. Barone, E.M. Valente (Italy, *Canada, **United Kingdom) P 1.122 Compulsive eating and olfaction in Parkinson’s disease A. Gonçalves, A. Mendes, N. Vila-Chã, I. Moreira, J. Fernandes, J. Damásio, S. Cavaco (Portugal) P 1.123 Effects of Parkinson’s disease on cognitive action control: insights on impulsive response tendencies using an oclomotor Simon task J. Duprez, J. Houvenaghel, S. Argaud, M. Vérin, P. Sauleau (France) P 1.124 Sensory attenuation and Parkinson’s disease: a new pathophysiological framework of bradykinesia A. Macerollo, J. Chen, P. Korlipara, T. Foltynie, J. Rothwell, M. Edwards, J. Kilner (United Kingdom) XXI World Congress on Parkinson’s Disease and Related Disorders Fine motor function skills in patients with Parkinson’s disease (PD) with and without mild cognitive impairment (MCI) P. Dahdal, A. Meyer, M. Chaturvedi, K. Nowak, A.D. Roesch, U. Gschwandtner, P. Fuhr (Switzerland) P 1.126 The relationship between impulse control disorders and dyskinesia in Parkinson’s disease: the ALTHEA study R.J. Vorovenci, L. Weiss, R. Biundo, A. Antonini (Italy) P 1.130 Continuous monitoring of PD with an affordable novel computerised motor test based on a tablet M. Da Lio, M. De Cecco, P. Bosetti, M. Malaguti (Italy) P 1.131 N30 somatosensory evoked potential is negatively correlated with motor function in Parkinson’s disease S.Y. Kang, H. Ma, H. Song, Y.H. Soh (South Korea) P 1.132 Reconsidering diagnosis and prevalence of neuropathy in PD A. Rubino, M.E. Di Battista, M. Valente, L. De Lipsis, G.O.R. Valente, G. Meco (Italy) P 1.133 Methylmalonic acid is an important factor that cause peripheral neuropathy in Idiopathic Parkinson`s disease J.-S.Park, P.-W. Go, K. Kang, H.-W. Lee (South Korea) P 1.134 A case series of coexisting Parkinson’s disease and epilepsy A. Son, D. Kaminski, A. Gurevich, M. Biagioni, B. Stone, R. Gilbert, M. Nirenberg, A. Di Rocco (USA) P 1.135 Parkinson’s disease with congenital porencephalia M. Khanova, N. Tolibova, O. Turgunkhujaev, K. Maksudova (Uzbekistan) P 2.001 Recognition of life-long curiosity in Parkinson’s disease treatment developments P. Riederer (Germany) P 2.002 Review of interventions to reduce hospitalisation in Parkinson’s disease S. Muzerengi, C. Herd, C. Rick, C.E. Clarke (United Kingdom) P 2.003 Does premorbid educational attainment modify motor compensation in Parkinson’s disease? Y.H. Sohn, M.K. Sunwoo, P.H. Lee (South Korea) P 2.004 Relationship between stay-at-home patients’ understanding of nformation regarding their Parkinson’s disease and the burden of spouse caregivers H. Takamoto, M. Hori (Japan) P 2.005 Usefulness of the well being map for the follow-up of Parkinson’s disease patients B. Schuller, Y. Zouitina, M. Lefranc, O. Godefroy, M. Tir, P. Krystkowiak (France) P 2.006 Pilates method guidelines for physical therapy in patients with Parkinson’s disease I. Mollinedo-Cardalda, J.M. Cancela Carral, G. Rodriguez-Fuentes (Spain) P 2.007 Restoration of tensegrity equilibrium can lead to beneficial modification of Parkinson disease’s motor symptoms L. Vucolova (USA) P 2.008 Impact of the whole body vibration training on the motor symptoms in Parkinson’s disease patients A. Karbowniczek, W. Niewiadomski, A. Gasiorowska, A. Strasz, G. Cybulski, E. Palasz, G. Niewiadomska (Poland) POSTER SESSION 1 - MONDAY, 7 DECEMBER P 1.125 53 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 1 - MONDAY, 7 DECEMBER 54 P 2.009 Impact of the whole body vibration training on activity of daily living and quality of life in Parkinson’s disease patients A. Karbowniczek, W. Niewiadomski, A. Gasiorowska, A. Strasz, G. Cybulski, E. Palasz, G. Niewiadomska (Poland) P 2.010 Changes in maximum static force of knee extensors caused by prolonged whole body vibration training in Parkinson’s disease patients W. Niewiadomski, A. Strasz, A. Karbowniczek, A. Gasiorowska, M. Zylinski, K. Pariaszewska, G. Cybulski, E. Palasz, G. Niewiadomska (Poland) P 2.011 Cases of negative effect of chronic whole-body vibration on the dynamics of the flow and the quality of life in patients with Parkinson’s disease O. Turgunkhujaev, N. Tolibova, M. Khanova, R. Matmurodov, K. Khalimova (Uzbekistan) P 2.012 Longitudinal study of the effect of a combined exercise program (land and water) on the physical condition in elderly with Parkinson´s disease B. Mendez-Rial, J.M. Cancela Carral, C. Ayan, M.H. Vila, M. Seijo (Spain) P 2.013 The control of quiet stance in persons with Parkinson’s disease C. Rigoldi, M. Galli, L. Mainardi, G. Guffanti, A. Maras, G. Riboldazzi (Italy) P 2.014 Effects of trunk proprioceptive neuromuscular facilitation on dynamic balance, mobility and quality of life in Parkinson’s disease B.S. Sneha, S. Karthikbabu, N. Syed*, L.K. Prashanth (India, *Canada) P 2.015 Use of three-dimensional gait analysis to assess the effectiveness of conventional rehabilitation protocols in people with Parkinson’s disease M. Pau, F. Corona, C. Casula, R. Pili, M. Murgia, M. Guicciardi (Italy) P 2.016 A pilot study: evaluation of a tactile cueing device prototype for patients with Parkinson’s disease R. Schweinfurther, M. Herold-Nadig, V. Klamroth-Marganska, S. Neumann, S. Brühlmann, A. Menig, D. Zutter, J.C. Möller, M. Oechsner, R. Riener (Switzerland) P 2.019 Center of pressure displacements during gait initiation in individuals with Parkinson’s disease C. Rigoldi, M. Galli, A. Maras, G. Riboldazzi (Italy) P 2.020 The worse is the clinical status of the patient with Parkinson, the higher is the stride length percentage of improvement after automated mechanical peripheral stimulation A. Kleiner, M. Galli, M. Gaglione, D. Hildebrand*, P. Sale, G. Albertini, F. Stocchi, M.F. De Pandis (Italy, *Brazil) P 2.021 Neurofeedback in Parkinson’s disease S. Esmail, D. Linden (United Kingdom) P 2.022 A pilot randomised controlled trial (RCT) of real-time fMRI neurofeedback and motor training for the treatment of Parkinson’s disease (PD) L. Subramanian, M. Busse, M. Brosnan*, D. Turner, H. Morris, D. Linden (United Kingdom, *Ireland) P 2.023 Effects of virtual reality exercise program on balance in lower parkinsonism patients G. Lee (South Korea) XXI World Congress on Parkinson’s Disease and Related Disorders Stress Reduction Training in PD Patients - Influence on neuropsychiatric symptoms? A. Meyer, A. Hadinia, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) P 2.025 Cognitive Behavioral Group Therapy (CBT) for stress reduction in patients with Parkinson’s disease. A randomized control trial A. Hadinia, A. Meyer, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) P 2.026 Quality of life measured by PDQ39 and SEIQoL during anti-stress training for Parkinson’s disease (PD) patients K. Nowak, A. Meyer, M. Chaturvedi, A. Hadinia, U. Gschwandtner, P. Fuhr (Switzerland) P 2.027 Cortisol measurements as a laboratory biomarker for stress reduction in Parkinson’s disease (PD) patients K. Nowak, A. Meyer, A. Hadinia, M. Chaturvedi, A.D. Roesch, U. Gschwandtner, P. Fuhr (Switzerland) P 2.028 Effects of cognitive loading on standing balance and postural stability in Parkinson’s disease patients with freezing of gait W. Buated, P. Lolekha*, T. Fujinami, S. Hidaka, N. Kashyap (Japan, *Thailand) P 2.029 Learning rhythm: an innovative multifunctional neuro-rehabilitative method to improve cognitive performances in Parkinson’s disease patients S. Minella, S. Guzzetti, F. Mancini (Italy) P 2.030 The potential of cognitive-behavioral intervention for anxiety in Parkinson’s disease G.O. Reynolds, D.H. Barlow, A. Cronin-Golomb (USA) P 2.031 Short and long term effect of cognitive rehabilitation in mild cognitive impairment subtypes in Parkinson’s disease M. Diez-Cirarda, N. Ojeda, J. Peña, O. Lucas-Jimenez, M.Á. Gómez-Beldarrain, J.C. GómezEsteban, N. Ibarretxe-Bilbao (Spain) P 2.032 Treatment and diagnosis with the use of neuropsychological scale in patients with subcortical parkinsonian dementia N. Sokhibnazarov, F. Muratov (Uzbekistan) P 2.033 Theatre is a valid complementary therapeutic interventions for emotional rehabilitation of Parkinson’s patients G. Mirabella, P. De Vita, S. Rampelli, F. Lena, F. Dilettuso, M. Iacopini, R. D’Avella, M.C. Borghese, S. Mazzotta, D. Lanni, M. Grano, S. Lubrani, N. Modugno (Italy) P 2.034 Beneficial role of voice inter-relating process and OM mantra enchanting in Parkinson’s disease patients in south Delhi metro population V. Sharma (India) P 2.035 New opportunities for innovation and internet technologies in rehabilitation of patients with Parkinson’s disease in the Aral Sea region of the Republic of Uzbekistan G. Izyumova, D. Izyumov (Uzbekistan) P 2.036 Zero non-motor symptoms in a martial arts’ expert L. Jaffe (USA) POSTER SESSION 1 - MONDAY, 7 DECEMBER P 2.024 55 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 56 POSTER SESSION 2 (2.037-3.087) P 2.037 Pharmaceutical design in Parkinson’s disease: what do patients prefer? K. Lefteri, F. Liu, M. Brown (United Kingdom) P 2.038 Effect of pharmacist-led interventions on motor symptoms in Parkinson’s patients: a pilot study C. Stuijt, T. Van Laar (The Netherlands) P 2.039 Unlocking Alzheimers and Parkinsonism - Do you dream for cure? J. Joy (India) P 2.040 Protective effects of superoxide dismutation activity in genetic models of Parkinson’s disease A. Biosa, F. Roberta, V.K. Godena*, A. Sanchez-Martinez*, L. Bubacco, M. Beltramini, A.J. Whitworth*, M. Bisaglia (Italy, *United Kingdom) P 2.041 Randomized double-blind, placebo-controlled multi-center trial for determining efficacy of molecular hydrogen water for Parkinson’s disease, baseline characteristics A. Yoritaka, N. Hattori, The Hydrogen Water Parkinson Study Group (Japan) P 2.042 Pharmacogenetics of levodopa: an algorithm for dose prediction V. Altmann, M. Rieck, A. Schumacher-Schuh, S. Callegari-Jacques, C. de Mello Rieder, M. Hutz (Brazil) P 2.043 Gait analysis in Parkinson’s disease assessing the effect of levodopa using a validated electronic walkway B. Mondal, S. Choudhury, R. Banerjee, P. Chatterjee, M.U. Kulsum, S. Chatterjee, K. Chatterjee, S. Sen, A. Ghoshal, S. Shubham, D. Naskar, S.S. Anand, H. Kumar (India) P 2.044 Treatment with l-dopa normalize learning as measured with CVLT-2 in drug naive patients with Parkinsons`disease H.T.J. Sari, O.B. Tysnes, J.P. Larsen, A. Gramstad, G.O. Skeie (Norway) P 2.045 Dopaminergic therapy: on a number of complications as increasing of libido in patients with Parkinson’s disease and Parkinson’s syndrome S. Mirdedaev (Uzbekistan) P 2.046 Dyskinesia and L-dopa treatment J. Nunomura, M. Tomiyama, C. Suzuki, A. Arai, H. Nishijima, R. Haga, T. Ueno, T. Kon, Y. Funamizu (Japan) P 2.047 Role of striatal projection neurons in the generation of L-DOPA-induced dyskinesia C. Alcacer, I. Sebastianutto, T. Fieblinger, J. Jakobsson, A. Cenci (Sweden) P 2.048 The effectiveness of amantadine and dopamine in the treatment of Guillain-Barre syndrome M. Tadjenov, R. Sadikov, Y. Musaeva, S. Kuranbaeva (Uzbekistan) P 2.049 Efficacy of rasagiline in PD patients with mild cognitive impairment D. Weintraub, R.A. Hauser, M. Davis, A. Choudhry (USA) P 2.050 Symptomatic efficacy of rasagiline in early PD: a meta-analysis R.A. Hauser, R. Eliaz, E. Eyal, V. Abler, T. Schilling (USA) XXI World Congress on Parkinson’s Disease and Related Disorders H-3 receptor antagonist anD JNK-3 inhibitor: a new therapeutic approach to treat Parkinson’s disease N. Ambhore, S. Mohire, R.R. Kalidindi, S. Mulukutala, V. Murthy*, E. Kannan (India, *USA) P 2.052 Motor effects of phosphodiesterase 9 inhibition in the non-human primate model of Parkinson’s disease G. Masilamoni, A. Singh, X. Tang, A. McRiner, L. Leventhal, S. Papa (USA) P 2.053 Impact of current antipsychotic medications on comparative mortality and adverse events in people with Parkinson’s disease psychosis (PDP) R. Mills, C. Ballard*, S. Isaacson, H. Williams, A. Corbett*, B. Coate, R. Pahwa, O. Rascol**, D. Burn* (USA, *United Kingdom, **France) P 2.054 Parkinson’s disease with psychosis (PDP): role of 5-HT2A receptors R. Horowski, P.-A. Loeschmann, P. Riederer (Germany) P 2.055 Efficacy and tolerability of NUPLAZID™ (pimavanserin) in PD psychosis: analysis of an integrated phase 3 placebo-controlled dataset R. Mills, J. Friedman, W. Ondo, R. Pahwa, K. Black, K. Chi-Burris, H. Williams (USA) P 2.056 Long-term effectiveness of NUPLAZID™ (pimavanserin) in PD psychosis: Data from 2 open-label studies R. Mills, S. Isaacson, J. Azulay*, J. Ferreira**, D. Kreitzman, T. Ilic***, K. Chi-Burris, H. Williams (USA, *France, **Portugal, ***Serbia) P 2.057 Antiparkinsonian medication adjustments following deep brain stimulation of subthalamic nucleus in patients with advanced Parkinson’s disease A. Gamaleya, E. Bril, A. Tomskiy, N. Gubareva, A. Poddubskaya, N. Fedorova, V. Shabalov (Russia) P 2.060 Onset and duration of motor effects with IPX066, levodopa-carbidopa extended-release capsules: comparison with immediate-release levodopa-carbidopa and with levodopa-carbidopa+entacapone S. Gupta, S. Khanna, R. Rubens, N. Modi (USA) P 2.061 Outpatient levodopa-carbidopa intestinal gel titration in patients with advanced Parkinson’s disease R. Rodriguez, M. Lobatz, J. Dubow, S. Eaton, C. Hall, K. Chatamra, J. Benesh (USA) P 2.062 Evodopa-Carbidopa intestinal gel treatment in patients with < 10 years of Parkinson's disease: GLORIA Registry interim results A. Antonini, K.R. Chaudhuri*, L. Bergmann**, A. Yegin**, K. Onuk**, W. Poewe*** (Italy, *United Kingdom, **USA, ***Austria) P 2.063 The impact of levodopa-carbidopa intestinal gel on health-related quality of life in Parkinson’s disease N. Kovács, G. Deli, Z. Aschermann, P. Ács, A. Makkos, M. Kovács, J. Janszky, S. Komoly (Hungary) P 2.064 Effects of levodopa-carbidopa intestinal gel on non-motor symptoms and safety of outpatient titration: a new phase 3 study in patients with advanced Parkinson’s disease D. Standaert, J. Slevin, C. Hall, J. Dubow, S. Eaton, K. Chatamra, J. Benesh (USA) POSTER SESSION 2 - TUESDAY, 8 DECEMBER P 2.051 57 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 58 P 2.065 Telemedicine facilitates efficient and safe home titration of Levodopa/Carbidopa Intestinal Gel (LCIG) in patients with advanced Parkinson’s disease T. Willows, N. Dizdar, D. Nyholm, H. Widner, K. Groth, J. Larsson, J. Permert, S. Kjellander (Sweden) P 2.066 Determination of minimal important difference thresholds for Parkinson’s Disease Questionnaire-39 in advanced Parkinson’s disease patients A. Antonini, E. Dansie Bacci*, K. Sail*, Y.J. Jalundhwala*, P.L. Kandukuri*, T. Marshall*, K. Chatamra*, I. Wiklund**, D. Revicki* (Italy, *USA, **United Kingdom) P 2.067 Gastrointestinal safety of levodopa-carbidopa intestinal gel in advanced Parkinson’s disease patients: GLORIA long-term registry interim results D. Domagk, S. Dam-Larsen*, **A. Antonini, L. Bergmann***, A. Yegin***, W. Poewe**** (Germany, *Denmark, **Italy, ***USA, ****Austria) P 2.068 Updated long-term safety from ongoing phase 3 trials of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease R. Rodriguez, N. Schmulewitz, D. Stein, W. Robieson, C. Hall, S. Eaton, K. Chatamra, J. Benesh, A. Espay (USA) P 2.069 Italian survey on intraduodenal levodopa gel treatment in advanced Parkinson disease: state of the art 10 years after marketing M. Sensi, G. Cossu, F. Mancini, N. Modugno, M. Pilleri, R. Quatrale, F. Tamma, M. Zibetti, M. Aguggia, A. Antonini, L. Bartolomei, M. Amboni, D. Calandrella, M. Canesi, M.G. Ceravolo, R. Ceravolo, P. Cortelli, R. Eleopra, E. Grassi, M. Guido, G. Gusmaroli, M. Coletti, P. Marano, F. Morgante, C. Pacchetti, G. Riboldazzi, S. Rossi, A. Stefani, G. Meco, A. Tessitore, G. Fabbrini, M.V. Saddi (Italy) P 2.070 Comparison of the antiparkinsonian and antidyskinetic effects of hemantane and amantadine E. Ivanova, I. Kapitsa, E. Valdman, T. Voronina (Russia) P 2.071 Favourable effect of safinamide on mood over 2-year treatment of fluctuating Parkinson’s disease patients C. Cattaneo, R. La Ferla, E. Müller*, M. Sardina (Italy, *Germany) P 2.072 Post-hoc analysis of safinamide studies as add-on therapy to levodopa in mid- to late-stage fluctuating Parkinson’s Disease patients C. Cattaneo, R. La Ferla, E. Bonizzoni, M. Sardina (Italy) P 2.073 Efficacy and safety of istradefylline for the treatment of non-motor symptoms and quality of life (QOL) in patients with Parkinson’s disease K. Abe, S. Kitamura, J. Ogura, M. Fujita, H. Yoshikawa (Japan) P 2.075 Clinical characteristics of Parkinson’s disease patients responsive to Istradefylline treatment T. Hazama, K. Fukada, Y. Mitani, M. Kinoshita, K. Takata, Y. Kokunai, J. Sawada (Japan) P 2.076 Efficacy and safety of istradefylline for the treatment of non-motor symptoms and quality of life (QOL) in patients with Parkinson’s disease and QOL in their caregivers K. Abe, S. Kitamura, J. Ogura, M. Fujita, H. Yoshikawa (Japan) XXI World Congress on Parkinson’s Disease and Related Disorders One-year follow-up of opicapone’s efficacy and safety in patients with Parkinson’s disease and motor fluctuations (BIPARK I) J. Ferreira, A. Lees*, A. Santos, N. Lopes, J. Rocha, P. Soares-da-Silva (Portugal, *United Kingdom) P 2.078 The 1-Metylxantine affinity for A2A adenosine receptors is similar to caffeine, theobromine, theophylline and adenosine. The importance of xanthine core L.C. Jimenez-Botello, R.B. Muñoz-Soto, I. Castilla De Cortazar Larrea, M. Garcia-Magariño Alonso, M.A. Soriano-Ursua, J. Correa-Basurto (Mexico) P 2.079 Meta-analysis: donepezil in the treatment of cognitive impairment & dementia in patients with Parkinson’s disease E. Barcelon, L. Shiong Shu, P.M. Pasco (Philippines) P 2.080 Pooled efficacy of opicapone as adjunctive therapy to levodopa in patients with Parkinson’s disease and motor fluctuations J. Ferreira, A. Lees*, N. Lopes, A. Santos, J. Rocha, P. Soares-da-Silva (Portugal, *United Kingdom) P 2.081 Pooled safety and tolerability of opicapone in the treatment of Parkinson’s disease and motor fluctuations A. Lees, J. Ferreira*, H. Gama*, C. Oliveira*, N. Lopes*, J. Rocha*, P. Soares-da-Silva* (United Kingdom, *Portugal) P 2.082 PANDA: prolonged release oxycodone/naloxone (OXN PR) for severe Parkinson’s disease (PD)related pain K.R. Chaudhuri, P. Martinez-Martin*, O. Rascol**, M. Lomax, J. Decesare, M. Hopp*** (United Kingdom, *Spain, **France, ***Germany) P 2.083 A study of real life tolerability of rotigotine transdermal patch in Parkinson’s disease across all motor stages R. Barreto, A. Sauerbier, A. Rizos, R. Chaudhuri (United Kingdom) P 2.084 Rotigotine efficacy on sleep disturbances in Parkinson’s Disease patients: evidence from a polysomnographic study C. Liguori, M. Pierantozzi, F. Placidi, A. Stefani (Italy) P 2.085 Chronic subcutaneous infusion therapy with apomorphine in advanced Parkinson’s disease: effects on motor and non motor symptoms with brain metabolism correlations M. Auffret, A. Maurus, M. Vérin, J. Houvenaghel, F. Le Jeune, S. Drapier (France) P 2.086 Efficacy of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson’s disease A. Agro, J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, H. Shill*, R. Hauser* (Canada, *USA) P 2.087 The effects of sublingual apomorphine (APL-130277) by disease severity on the acute reversal of OFF episodes in Parkinson’s disease patients J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, A. Agro (Canada) P 2.088 Baseline disease severity not predictive of sublingual apomorphine (APL-130277) dose needed to convert a PD patient from the OFF to ON state J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, A. Agro (Canada) POSTER SESSION 2 - TUESDAY, 8 DECEMBER P 2.077 59 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 60 P 2.089 Safety of sublingual apomorphine (APL-130277) for the treatment of OFF episodes in patients with Parkinson’s disease A. Agro, J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, S. Isaacson* (Canada, *USA) P 2.090 Minimum MDS-UPDRS part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with sublingual apomorphine (APL-130277) J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, A. Agro (Canada) P 2.091 Differences between apomorphine (APO) and lisuride (LIS) in PD therapy R. Horowski (Germany) P 2.092 A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson’s disease: the pilot study E. Scelzo, E. Beghi, M. Rosa, E. Bianchi, C. Pacchetti, A. Antonini, L. Romito, L. Lopiano, N. Modugno, F. Tamma, A. Priori (Italy) P 2.093 A comparison of deep brain stimulation and continuous intrajejunal levodopa infusion in advanced Parkinson’s disease: The INVEST study D. Van Poppelen, R.M. De Bie, J.M. Dijk (The Netherlands) P 2.094 Multicenter experience of mixed deep brain stimulation implants for moviment disorders F. Preda, C. Cavandoli, A. Antonini, R. Eleopra, M. Mondani, S. Sarubbo, A. Martinuzzi, M. Pilleri, M. Cavallo, A. Landi, M. Sensi (Italy) P 2.095 Effect of bilateral subthalamic DBS on gait in patients with idiopathic Parkinson’s disease R. Borgohain, R.M. Kandada, V.P.V. Kagita, A.K. Puligopu, S.A. Jabeen, M.A. Kanikannan (India) P 2.096 The effect of bilateral sub-thalamic nucleus deep brain stimulation (STN-DBS) on prosody of speech of Parkinson’s disease F. Majdinasab, S.A.H. Habibi, E. Ghorbani, M. Khoddami (Iran) P 2.097 The effect of deep brain stimulation of subthalamic nucleus on cognitive functions in Parkinson’s disease - Pilot study K. Potasz-Kulikowska, K. Kulikowski, A. Górecka-Mazur, W. Pietraszko, J. Polak, A. Krygowska-Wajs (Poland) P 2.098 The effect of subthalamic deep brain stimulation on ghrelin levels in Parkinson’s disease A. Chrobak, A. Furgała, S. Jeziorko, G. Siwek, W. Pietraszko, M. Moskała, K. PotaszKulikowska, U. Fiszer, A. Krygowska-Wajs (Poland) P 2.099 Can intraoperative clinical testing predict stimulation-induced effects of STN-DBS? J. Blume, E. Rothenfußer-Korber, A. Janzen, U. Bogdahn, J. Schlaier, M. Lange (Germany) P 2.100 Subthalamic deep brain stimulation in Parkinson’s disease: does the therapeutic range remain the same in the absence of clinical intraoperative testing? Y. Zouitina, M. Lefranc, A. Benoist, P. Merle, D. Montpellier, M. Roussel, J.M. Constans, J.M. Macron, O. Godefroy, M. Tir, P. Krystkowiak (France) P 2.101 Deep brain stimulation of STN for advanced Parkinson disease with octopolar leads: programming electrical parameters guided for a neuroanatomical-3D-image software 12 months follow-up G. Salazar (Spain) XXI World Congress on Parkinson’s Disease and Related Disorders The impact of microelectrode recording on selecting the most optimal trajectories for electrode implantation M. Nagy, N. Kovács, Z. Aschermann, G. Deli, I. Balás (Hungary) P 2.103 Effect of high versus low frequency subthalamic nucleus deep brain stimulation in freezing of gait S. Asaadi, Z. Gholizadeh Ghozloujeh, A. Zali, F. Ashrafi, R. Jalili Khoshnood (Iran) P 2.104 Comparative study of microrecording-based STN location and MRI-based STN location R. Verhagen, P.R. Schuurman, P. Van Den Munckhof, M.F. Contarino, R.M.A. De Bie, L.J. Bour (The Netherlands) P 2.105 Three new techniques for improving DBS therapy: what are we waiting for? L. Bour, F. Contarino, S. Van Gils (The Netherlands) P 2.106 Reflex saccades evaluation can estimate long-term symptom progression in DBS STN vs only medically treated Parkinson’s disease patients S. Szlufik, A. Przybyszewski, J. Dutkiewicz, P. Habela, T. Mandat, D. Koziorowski (Poland) P 2.107 High frequency repetitive transcranial magnetic stimulation can improve the quality of life and depression in Parkinson’s disease: a randomized, double-blind, placebo-controlled study N. Kovács, G. Deli, Z. Aschermann, A. Makkos, M. Kovács, J. Janszky, E. Pál (Hungary) P 2.108 The impact of STN DBS on kinetic tremor in Parkinson’s disease patients S. Szlufik, M. Szumilas, J. Dutkiewicz, D. Koziorowski, T. Mandat, E. Slubowska (Poland) P 2.109 Weight gain after subthalamic nucleus deep brain stimulation in PD: the role of electrodes position, hormonal setting and clinical outcome M. Fichera, D. Baroncini, R. Balestrino, A. Franzin, G. Comi, M.A. Volonté (Italy) P 2.110 The three-dimensional motion analysis system as an useful tool in evaluation of gait disorders in Parkinson’s disease patients treated with DBS STN S. Szlufik, M. Stolarczyk, J. Dutkiewicz, A. Stolarczyk, T. Mandat, A. Friedman, J.M. Deszczynski, D. Koziorowski (Poland) P 2.111 Current status of the treatment with Deep Brain Stimulation (DBS) conducted in Ehime, Japan H. Yabe, K. Tanaka, R. Ando, H. Iwaki, N. Nishikawa, M. Nagai, M. Nomoto (Japan) P 2.112 The combined depletion of monoamines alters the effectiveness of subthalamic deep brain stimulation E. Faggiani, C. Delaville, A. Benazzouz (France) P 2.113 Unilateral deep brain stimulation of subthalamic nuclei does not affect reactive inhibition in Parkinson’s patients G. Mirabella, G. Giannini, M. Fragola, M. Santilli, N. Modugno (Italy) P 2.114 Impact of gait and balance training on advanced Parkinson’s disease patients after bilateral STN-DBS V.P.V. Kagita, D.R. Borgohain, D.A. Kumar, D.R.M. Kandadai, S.A. Jabeen, M.A. Kanikannan (India) P 2.115 Is emotional prosody of speech affected by Quality of life and depression in bilateral sub-thalamic nucleus deep brain stimulation (STN-DBS) of Parkinson’s disease? F. Majdinasab, S.A.H. Habibi, E. Ghorbani, S.A. Khatoonabadi, S. Salehi (Iran) POSTER SESSION 2 - TUESDAY, 8 DECEMBER P 2.102 61 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 62 P 2.116 Impulse control disorders in Parkinson’s disease and effect of bilateral STN DBS on them R.M. Kandadai, R. Borgohain, S.A. Jabeen, M.A. Kanikannan, A.K. Pulligopu, V.V.P. Kagita (India) P 2.117 Mortality of advanced Parkinson’s disease patients who received deep brain stimulation surgery H. Ryu, M. Kim, S. You, M. Kim, Y.J. Kim, J. Kim, K. Kim, S.J. Chung (South Korea) P 2.118 Infections related to deep brain stimulation in patients with Parkinson’s disease: clinical characteristics and risk factors M.S. Kim, J.S. Jeong, H. Ryu, S.J. Chung (South Korea) P 2.119 Deep brain stimulation babies E. Scelzo, J. Mehrkens*, K. Bötzel*, P. Krack, A. Mendes**, S. Chabardes, M. Polosan, E. Seigneuret, E. Moro, V. Fraix (France, *Germany, **Portugal) P 2.120 Photo-stimulating effect of low reactive level laser can improve overactive bladder in a patient with Parkinson disease? T. Uchiyama, T. Yamamoto, Y. Watanabe, T. Kadowaki, K. Suzuki, K. Hashimoto, K. Kaga, C. Shibata-Yamaguchi, T. Yamanishi, R. Sakakibara, S. Kuwabara, K. Hirata (Japan) P 2.121 A comparison study for the optimal stimulation site of high-frequency repetitive transcranial magnetic stimulation in Parkinson’s disease M. Yokoe, T. Maruo, K. Hosomi, T. Shimokawa, H. Kishima, S. Oshino, S. Morris, Y. Kageyama, Y. Goto, T. Shimizu, H. Mochizuki, T. Yoshimine, Y. Saitoh (Japan) P 2.122 Transcranial magnetic stimulation for rehabilitation of axial symptoms in Parkinson’s disease M. Biagioni, S. Agarwa, K. Sticklor, G. Dacpano, A. Cucca*, A. Son, P. Kumar, D. Kaminski, A. Gurevich, M. Brys, F. Battenberg, A. Quartarone, A. Di Rocco (USA, *Italy) P 2.123 Adult neural progenitor cells auto transplantation in a non-human primate model of Parkinson’s disease: a pre-clinical study J. Cottet, S. Badoud, S. Borgognon, P. Chatagny, M. Fregosi, V. Moret, J. Bloch, J. Brunet, E. Rouiller (Switzerland) P 2.124 Differential induction of dyskinesia and inflammatory responses by intermittent versus continuous L-DOPA delivery in the 6-OHDA model of Parkinson’s disease A.R. Carta, G. Mulas, S. Spiga, D. Lecca E. Pillai (Italy) P 2.125 Association of α-synuclein gene expression with Parkinson’s disease is attenuated with higher serum urate in the PPMI cohort M. Schwarzschild, K. Fitzgerald, R. Bakshi, E. Macklin, C. Scherzer, A. Ascherio (USA) P 2.126 The experience of the Unit of Functional Neurosurgery - Hopital des Specialites Rabat - in the surgical management of movements desorders E. Hakkou, A. Melhaoui, Y. Arkha, W. Regragui, M. Jiddane, A. El Khamlichi, A. El Ouahabi (Morocco) P 3.001 Clinical and neuropathological features of rapid progressive dementia with lewy bodies A. Geut, D. Hepp, A. Ingrassia, Y. Galis, E. Foncke, A. Lemstra, A. Rozemuller, W. Van De Berg (The Netherlands) P 3.002 Clinical usefulness of F18-FP-CIT PET/CT in possible dementia with Lewy bodies: preliminary study J. Ahn, J. Heo, H. Kim (South Korea) XXI World Congress on Parkinson’s Disease and Related Disorders The association with cognitive function in Lewy body disease: The study of serum biomarkers S. Nakashita, Y. Tajiri, K. Wada-Isoe, K. Nakashima (Japan) P 3.004 Lysosomal enzyme activities in postmortem brain tissue of patients with Lewy Body disease T. Moors, S. Paciotti*, A. Ingrassia, D. Chiasserini*, P. Eusebi*, L. Parnetti*, T. Beccari*, W. Van De Berg (The Netherlands, *Italy) P 3.005 The plasma level of alpha-synuclein in lysosomal storage diseases B. Muinjonov, E. Giyazitdinova (Uzbekistan) P 3.006 Lewy body disease as pure autonomic failure with more than 20 years history: a post mortem study K. Oiwa, Y. Hasegawa, K. Yasui, Y. Iwasaki, M. Yoshida, A. Takahashi (Japan) P 3.007 Typical atypical or atypical atypical Parkinsonism? S.T. Hirschbichler, R. Erro, M. Stamelou*, B. Balint, K. Bhatia (United Kingdom, *Greece) P 3.008 Gastrointestinal symptom is a significant indicator of nigrostriatal dopaminergic degeneration in idiopathic REM sleep behavior disorder patients J. Lee, C.M. Shin, E.J. Yun, Y. Kim, B.S. Jeon (South Korea) P 3.009 Case study of sporadic multiple system atrophy at a young age B. Muinjonov, E. Giyazitdinova (Uzbekistan) P 3.010 The earliest finding of brain MRI in a case with the Parkinson variant of multiple system atrophy: clinical usefulness of diffusion-weight imaging K.Y. Kwon (South Korea) P 3.011 Anatomical profile of cognitive impairment in MSA E. Fiorenzato, R. Biundo, L. Weis, K. Seppi*, M. Onofrj, P. Cortelli, H. Kaufmann**, F. Krismer*°, G. Wenning*, A. Antonini (Italy, *Austria, **USA) P 3.012 Case report: multiple system atrophy C L. Fazzi, P.R.J.P. Gianotti, J.R.T. Ponte Junior, I.F.D.S. Massaia, M.A.G.T. Silva, M.L. Gorzoni, R.A.J. Ocha, W.L. Sanvito, B.G. Dutra (Brazil) P 3.013 Cognitive function in multiple system atrophy-C (cerebellar type) Y. Yang (South Korea) P 3.014 Generation and characterization of iPSC-derived cortical pyramidal neurons from patients affected by multiple system atrophy G. Monzio Compagnoni, E. Frattini, S. Salani, F. Fortunato, N. Bresolin, G.P. Comi, S. Corti, A. Di Fonzo (Italy) P 3.015 Confocal laser microscopy and 3D reconstruction of Pick-like and ring-like inclusions in atypical multiple system atrophy B. Sikorska, G.G. Kovacs*, P.P. Liberski (Poland, *Austria) P 3.016 Hyposmia in progressive supranuclear palsy B. Muinjonov, E. Giyazitdinova (Uzbekistan) P 3.017 Diagnosis of progressive supranuclear palsy in a memory clinic setting C. Nilsson, K. Tilderkvist, A. Santillo, M. Landqvist Waldö, K. Nilsson, D. Van Westen, S. Vestberg, E. Englund (Sweden) POSTER SESSION 2 - TUESDAY, 8 DECEMBER P 3.003 63 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 64 P 3.018 Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC): a prospective multicenter PSP/ CBD cohort study in Japan H. Takigawa, T. Ikeuchi, I. Aiba, M. Morita, O. Onodera, T. Shimohata, T. Tokuda, S. Murayama, K. Nakashima, JALPAC Study Group (Japan) P 3.019 Progression of atrophy in brainstem structures for differentiation of progressive supranuclear palsy–parkinsonism from Parkinson’s Disease M. Hwang (South Korea) P 3.020 Regional brain atrophy and cognitive impairment of pure akinesia with gait freezing J.Y. Hong, H.J. Yun, M.K. Sunwoo, J.H. Ham, J. Lee, Y. Sohn, P.H. Lee (South Korea) P 3.021 Corpus callosum volumetry as a tool to differentiate subtypes of progressive supranuclear palsy A. Lenka, S.A. Pasha, S. Mangalore, K. Jhunjhunwala, R. Yadav, J. Saini, P.K. Pal (India) P 3.022 Parkinson’s disease or symptomatic parkinsonism? Can they be combined? A. Voskanyan, S. Khachaturyan*, K. Harutyunyan, G. Avagyan, E. Khachatryan, H. Amirjanyan, I. Gabrielyan, H. Manvelyan (Armenia) P 3.023 Whether the Parkinson’s disease develops in patients with chronic cerebral ischemia? D. Izyumov, G. Izyumova (Uzbekistan) P 3.024 Comparative analysis of cognitive and affective disorders at vascular parinsonism and Parkinson’s disease S. Djalilova, Z. Ibodullayev, A. Mamadaliyev, D. Abdullayeva (Uzbekistan) P 3.025 Vascular parkinsonism as a common manifestation of second stage of CADASIL syndrome B. Muinjonov, E. Giyazitdinova (Uzbekistan) P 3.026 Neuroophthalmic disorders in children with cerebral palsy I. Abdukadirova, Y. Madjidova (Uzbekistan) P 3.027 Did Charcot have vascular parkinsonism? H. Teive, F.M. Branco Germiniani, R. Puppi Munhoz* (Brazil, * Canada) P 3.028 Movement disorders after stroke in third level hospital Marrakech morocco A. Chahidi, M. Chraa*, N. Kissani* (France, *Morocco) P 3.030 Use of the drug choline ALFOSTSERAT in combined treatment of vascular Parkinsonism O. Kurbanov, N. Nurmetov, Z. Ibodullaev, D. Abdullaeva (Uzbekistan) P 3.031 Analysis of the effectiveness of CEA and evaluation of factors affecting its long-term results M. Ataniyazov, G. Rakhimbaeva (Uzbekistan) P 3.032 Effect of rhythmic auditory stimulation on gait in patients with stroke M. Fouad, G. Mousa (Egypt) P 3.033 Acute parkinsonism as a predominant sign of neuroleptic malignant syndrome in a patient with schizophrenia P. Koprivnik (Slovenia) P 3.035 Parkinsonism in acute hepatic encephalopathy: Experimental evidence in rat O. El Hiba, A. Abbaoui, H. Gamrani (Morocco) XXI World Congress on Parkinson’s Disease and Related Disorders Parkinsonism in patient diagnosed as multiple sclerosis-case report N. Khizanishvili, M. Beridze, M. Mdivani, E. Devidze, L. Shanidze, N. Kvirkvelia (Georgia) P 3.037 Implication of CD4 in progression of Parkinsonian syndrome on patients with lupus erythematosus S. Bebitov, K. Mirzaeva, G. Rakhimbaeva (Uzbekistan) P 3.038 Enteric fever presenting as catatonia and parkinsonism: an unusual presentation S.K. Jaiswal (India) P 3.039 Predictive value of [123I]FP-CIT-SPECT on surgical outcome in idiopathic adult chronic hydrocephalus: a pilot study C. Del Gamba, F. Aquila, P. Perrini, D. Volterrani, U. Bonuccelli, N. Benedetto, R. Ceravolo (Italy) P 3.040 Impulse control disorders and punding in Perry syndrome T. Mishima, S. Fujioka, R. Kurisaki, S. Yanamoto, M. Higuchi, J. Tsugawa, J. Fukae, R. Neshige, Y. Tsuboi (Japan) P 3.042 Parkinsonism and central nervous system disease among lead exposed workers Y. Ahn (South Korea) P 3.043 Pesticide exposure and parkinsonism: a systematic review and meta-analysis M. Chondrogiorgi, I. Tzoulaki, E. Evangelou, G. Ntritsos, X. Tseretopoulou, M. Pappa, S. Konitsiotis, E. Ntzani (Greece) P 3.044 Neurotoxic alterations in pesticide exposed population: a preliminary study R.S. Yadav (India) P 3.045 The role of the motor cortex in essential tremor S. Sharifi, F. Luft, T. Heida, W. Mugge, A. Schouten, L. Bour, A. Van Rootselaar (The Netherlands) P 3.046 Development of a wireless sensor for tremors analysis D. Alimonti, P. Locatelli, M. Caldara, V. Re (Italy) P 3.047 Spike shape analysis of electromyography for parkinsonian tremor evaluation J. Marusiak, R. Andrzejewska, D. wiercz, K. Kisiel-Sajewicz, A. Jaskólska, A. Jaskólski (Poland) P 3.048 Unrevealing the diagnoses of a sample of cases with hard-to-classify tremor and normal DaT-SPECT M. Menendez-Gonzalez, T. Alvarez-Avellon, A. López-Muñiz, J. Vega Álvarez (Spain) P 3.049 Research on neuropsychiatric symptoms in patients with essential tremor and Parkinson’s disease in Latvian population L. Smeltere, V. Kuznecovs, R. Smelters (Latvia) P 3.050 Transcranial direct current stimulation in the treatment of essential tremor N. Helvaci Yilmaz, B. Polat, L. Hanoglu (Turkey) Impact of an interdisciplinary deep brain stimulation screening model on post-surgical complications in essential tremor patients M. Higuchi, M. Okun, Y. Tsuboi (Japan) P 3.051 P 3.052 POSTER SESSION 2 - TUESDAY, 8 DECEMBER P 3.036 Centrifugal progression of TDP-43 pathology along olfactory pathway in ALS patients in contrast to centripetal progression of alpha-synuclein pathology in PD patients T. Takeda, M. Iijima, T. Uchihara, C. Duyckaerts, S. Uchiyama, K. Kitagawa (Japan) 65 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 66 P 3.053 Clinical profile of Filipino patients with amyotrophic lateral sclerosis seen in a tertiary hospital: a 5 year-retrospective study M.A.K.D. Moll, J.P. Reyes (Philippines) P 3.054 Myokymia revealing multiple sclerosis H. Tibar, E. Ait Benhaddou, W. Regragui, A. Benomar, M. Yahyaoui, N. Birouk, M. Jiddane (Morocco) P 3.055 Pathogenetic mechanisms myoclonic hyperkinesia O. Kurbanov, N. Nurmetov, Z. Ibodullaev, D. Abdullaeva (Uzbekistan) P 3.056 Restless legs syndrome presenting as acute form in a patient with Guillain-Barre syndrome M. Ozmenoglu, V.A. Cakmak, N. Usta, S. Gazioglu (Turkey) P 3.057 Analysis of weight and BMI among patients with Huntington’s disease N. Szejko, L. Milanowski, A. Gogol, Z. Jamrozik, P. Janik (Poland) P 3.059 Hyperkinesia in ancient China: perspectives and prescriptions J. Liu, L. Wang (China) P 3.060 Cortical and subcortical neurodegeneration in chorea-acanthocytosis and Huntington’s disease: more differences than similarities J. Liu, H. Heinsen*, T. Arzberger*, B. Bader*, C. Schmitz*, M. Kiessling*, A. Danek* (China, *Germany) P 3.062 The rise, the fall and the revival of hyperglycemic hemichorea D. Lee, T. Ahn (South Korea) P 3.063 Inhaled steroid induced hemichorea-hemiballism H.J. Kim, H.J. Kang, S. Han (South Korea) P 3.064 Reversible hemichorea-hemiballism associated with post-thrombolysis reperfusion H.J. Kim, J.H. Jin, H. Roh, H.J. Kang, H.Y. Kim (South Korea) P 3.065 Tardive dyskinesia after long-term treatment with topical Prostoglandin F2α analog (latanoprost) B. Bulut, D. Ince Gunal, K. Agan Yildirim (Turkey) P 3.066 Neuroleptic Induced Dyskinesia or…? K. Harutyunyan, I. Gabrielyan, H. Amirjanyan, S. Khachaturyan, G. Avagyan, A. Nazaryan, A. Voskanyan, H. Manvelyan (Armenia) P 3.067 Novel GNAL mutation with intra-familial clinical heterogeneity: expanding the phenotype M. Carecchio, C. Panteghini, C. Reale, C. Barzaghi, V. Monti, L. Romito, F. Sasanelli, B. Garavaglia (Italy) P 3.068 Health-related quality of life in primary and secondary dystonia after pallidal deep brain stimulation M. Nagy, N. Kovács, Z. Aschermann, G. Deli, I. Balás (Hungary) P 3.069 DYT16/PRKRA founder mutation causes childhood-onset generalized dystonia in a family from Southern Italy M. Quadri, S. Olgiati, M. Sensi*, F. Gualandi*, E. Groppo*, V. Rispoli*, J. Graafland, G.J. Breedveld, G. Fabbrini*, V. Bonifati (The Netherlands, *Italy) XXI World Congress on Parkinson’s Disease and Related Disorders Affected side is a prognostic factor in typist’s cramp S.Y. Kang, S.K. Song, J.Y. Hong, J.H. Ham, S.J. Kim, H. Song, P.H. Lee, Y.H. Sohn (South Korea) P 3.071 A questionnaire survey of musician’s dystonia performed in a music college K. Konaka, M. Mihara, H. Mochizuki (Japan) P 3.072 Bias of visuo-spatial attention in cervical dystonia G. Chillemi, A. Calamuneri, F. Morgante, C. Terranova, V. Rizzo, P. Girlanda, A. Quartarone (Italy) P 3.073 Frequency of the pain and sleep problems at dystonia patients and influence of deep brain stimulation V. Vuletic (Croatia) P 3.074 A case of hemifacial spasm in young adult I. Gabrielyan, K. Harutyunyan, H. Amirjanyan, G. Avagyan, H. Hambardzumyan, S. Khachaturyan, A. Nazaryan, H. Manvelyan (Armenia) P 3.075 Atypical presentation of psychogenic movement disorder with jaw-opening dystonia: two cases reports W.T. Yoon (South Korea) P 3.076 Tobacco increases dystonia risk but may ameliorate symptoms C. Hellberg, A. Puschmann (Sweden) P 3.077 A cross-sectional structured survey of patients receiving botulinum toxin type A treatment for blepharospasm D. Truong, J. Fezza, J. Burns, J. Woodward, T. Hedges, A. Verma (USA) P 3.078 Therapeutic assessment of botulinum toxin in the treatment of hemifacial spasm H. Teive, J.P. Batisti, N. Galli, A.D. Kleinfelder (Brazil) P 3.079 Acute allergic reaction following injection of generic, government-provided botulinum toxin A (GGPBTA) for hemifacial spasm H. Teive, F.M. Branco Germiniani, R.H. Scola, R.N. Brito, G. Ribas, L. Fiuza Parolin, V. Scavasine, M. Canever, C.M. Borges, K.F. Miska Thölken, S. Zuneda Serafini (Brazil) P 3.080 Zolpidem in movement disorder after cardiac arrest H. Teive, W. Arruda, M. Silva, D. Bertholdo (Brazil) P 3.081 Paradoxical effect of a high frequency stimulation protocol on temporal discrimination in dystonic patients R. Erro, M. Tinazzi, J. Rothwell, K.P. Bhatia (United Kingdom) P 3.082 Dopaminergic medicines are drugs of choice for medicament-resistant facial nerve neuropathy A. Azimov, R. Sadykov, S. Dadajonov, O. Azizova, R. Ismoilov (Uzbekistan) P 3.083 Dopaminergic medicines are drugs of choice for medicament-resistant facial nerve neuropathy: EMG study A. Azimov, R. Sadykov, S. Dadajonov, O. Azizova, R. Ismoilov, E. Giyazitdinova (Uzbekistan) P 3.084 Late onset Wilson’s disease with central pontine and extrapontine MRI changes T. Biller, G. Fatterpekar, M. Nirenberg, M. Brys (USA) POSTER SESSION 2 - TUESDAY, 8 DECEMBER P 3.070 67 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 2 - TUESDAY, 8 DECEMBER 68 P 3.085 Wilson disease: acute dystonia during treatment with SSRI or SNRI L. Wictor, K. Wictorin, H. Widner, A. Puschmann (Sweden) P 3.086 A clinicoradiologic study of hypertrophic olivary degeneration T. Konno, A. Strongosky, D. Broderick, Z.K. Wszolek (USA) P 3.087 Interoceptive awareness in patients with functional motor disorders B. Demartini, L. Ricciardi*, L. Crucianelli*, C. Krahé*, M.J. Edwards*, A. Photopoulou* (Italy, *United Kingdom) XXI World Congress on Parkinson’s Disease and Related Disorders P 3.088 The distribution and progression pattern of adult onset cerebellar ataxias: hospital based study J.S. Kim, J. Cho, J.E. Yoon, J. Youn (South Korea) P 3.089 Idiopathic very late-onset cerebellar ataxia: a Brazilian case series H. Teive, A. Moro, M. Moscovich, W. Arruda, R. Munhoz (Brazil) P 3.090 Anthropometric profile of patients with Spinocerebellar Ataxia H. Teive, C. Leite, D. Macedo, M.E. Schieferdecker, R. Vilela, A. Moro (Brazil) P 3.091 Anthropometric equations to assess muscle mass in patients with spinocerebellar ataxia H. Teive, D. Macedo, C. Leite, M.E. Schieferdecker, R. Vilela, A. Moro, C. Taconeli (Brazil) P 3.092 Estimation of skeletal muscle mass in patients with spinocerebellar ataxia H. Teive, C. Leite, D. Macedo, M.E. Schieferdecker, R. Vilela, A. Moro (Brazil) P 3.093 Comparison of Non-motors symptoms in patients with Spinocerebellar ataxia type 10 and type 3 A. Moro, M. Moscovich, M. Farah, R. Munhoz, W. Arruda, S. Raskin, T. Ashizawa, H. Teive (Brazil) P 3.094 Sleep architecture observed in the patients with SCA 10 E. London, A.C. Crippa, M. Moscovich, T. Ashizawa, H. Teive (Brazil) P 3.095 Center of pressure velocity and its fast alternating deviations as an objective measure of balance – Normal values and their sensitivity investigated in SCA patients A. Sobanska, M. Rakowicz, L. Czerwosz, A. Sulek, I. Stepniak, R. Rola (Poland) P 3.096 The importance of the vestibular evaluation in the body balance prognosis and therapy in spinocerebellar ataxia B.S. Zeigelboim, H.A.G. Teive, J.H. Faryniuk, G. Santos, M.I. Severiano, V.R. Fonseca (Brazil) P 3.097 Otoneurological findings prevalent in hereditary ataxias B.S. Zeigelboim, H.A.G. Teive, G. Santos, M.I. Severiano, V.R. Fonseca, J.H. Faryniuk (Brazil) P 3.098 Labyrinth diseases in autosomal recessive ataxia B.S. Zeigelboim, H.A.G. Teive, G. Santos, M.I. Severiano, E. Abdulmassih, J.H. Faryniuk (Brazil) P 3.099 Non-invasive biomarkers for spinocerebellar ataxias, types 2 &12 patients and their correlation with cerebellar degeneration R.R. Moganty, V. Swarup, A.K. Srivastava, M.V. Padma (India) P 3.100 Clinical profile of hundred patients with Ataxia Telangiectasia from India M. Mahadevappa, D.V. Santhosh, M. Netravathi, R. Yadav, P.K. Pal (India) P 3.101 Burden of mitochondrial DNA variations in Friedreich’s Ataxia (FRDA) patients and sharing of mitochondrial lineage with Caucasians I. singh, S. Sakhya, M. Behari, M.V.P. Srivastava, G. Shukla, V. Goyal, A.K. Srivastava, M. Faruq (India) P 3.102 Distal hereditary motor neuropathy with HSJ1 chaperone mutation, presenting with peripheral motor neuropathy, associated to parkinsonism, and cerebellar ataxia. Case report H. Teive, F. Kok, S. Raskin, W. Arruda (Brazil) POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER POSTER SESSION 3 (3.088-6.070) 69 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER 70 P 3.103 Sporadic progressive ataxia with palatal tremor S. Agarwal, A. Son, J. Rucker, M. Brys (USA) P 3.104 HMG-CoA Reductase Inhibitors-induced cerebellar ataxia. A Brazilian case series A. Moro, M. Moscovich, W. Arruda, R. Munhoz, H. Teive (Brazil) P 3.105 Comparison of gait and cognitive function in the elderly with Alzheimer’s disease dementia, mild cognitive impairment and normal control S.W. Moon (South Korea) P 3.106 Movement disorders in Ethiopia S. Belay (Ethiopia) P 3.107 The role and significance of neuron specific protein S100B at extrapyramidal disorders M. Juraev, R. Matmurodov, K. Khalimova (Uzbekistan) P 4.002 Transcranial B-mode sonography in Parkinson’s disease and parkinsonism: our experience on 403 patients M. Ravagnani, K. Savio, P. Pastorello, D. Barbagli, M. Mongiovetti, G. Gusmaroli (Italy) P 4.003 Altered functional topography of the striatum in resting state FMRI in Parkinson’s disease S.N. Tan, Y. Zhang, A. Liu, J. Wang, M.J. Mckeown (Canada) P 4.004 Is the mechanism of nervous cells death in Parkinson different than in other neurodegenerations – Arguments from MRI study? A. Friedman, R. Kulinski, J. Galazka-Friedman (Poland) P 4.005 Volumetry of the olfactory bulbs and tracts in the differential diagnosis of Parkinson’s disease from parkinsonisms M. Menendez-Gonzalez, A. López-Muñiz, J. Vega Álvarez (Spain) P 4.006 Apathy is associated to altered resting-state functional connectivity and structural changes in Parkinson’s disease O. Lucas-Jiménez, N. Ojeda, J. Peña, M. Díez-Cirarda, A. Cabrera, J.C. Gómez-Esteban, M. Gómez-Beldarrain, N. Ibarretxe-Bilbao (Spain) P 4.007 Structural changes in basal ganglia-thalamocortical circuits in Parkinson’s disease with cognitive impairment A. Son, M. Biagioni, S. Agarwal, Y. Li, M. Brys, A. Di Rocco, J. Galvin (USA) P 4.008 Magnetic resonance characteristic of Parkinson’s disease based on the presence of cognitive impairments N. Okiljonova, Y. Madjidova (Uzbekistan) P 4.009 White matter changes associated with cognitive impairment in Parkinson’s disease M. Chondrogiorgi, L. Astrakas, A. Zikou, M. Argyropoulou, S. Konitsiotis (Greece) P 4.010 Putaminal diffusivity changes correlates with motor progression in Parkinson’s disease on 6-year follow-up L.L. Chan, K.M. Ng, C.S. Yeoh, H.H. Li, H. Rumpel, E.K. Tan (Singapore) XXI World Congress on Parkinson’s Disease and Related Disorders Magnetic resonance characteristic of Parkinson’s disease based on the presence of cognitive impairment D. Farangis Bonu (Uzbekistan) P 4.012 The 2D-Medial Temporal lobe Atrophy (2D-MTA) correlates with memory in Parkinson’s disease T. Alvarez Avellón, M. Menendez Gonzalez, F. Cuetos Vega, R. Ribacoba Montero (Spain) P 4.013 Changes of cerebral morphometry in patients with cerebrovascular and Parkinson’s diseases R. Bogdanov, S. Borisova, S. Kotov, G. Stashuk (Russia) P 4.014 Abnormal white matter integrity in elderly patients with idiopathic normal-pressure hydrocephalus: a tract-based spatial statistics study K. Kang, H. Lee, W. Choi, U. Yoon, J. Lee (South Korea) P 4.015 Exploring the grey matter correlates of Wilson’s disease using voxel based morphometry A.S. Sunny, L. George, K.R. Jhunjhunwala, A. Lenka, J. Saini, M. Netravathi, P.K. Pal (India) P 4.016 Arterial spin labeling (ASL) may be useful for diagnosing existence of dementia in Parkinson’s disease K. Abe, T. Yamamoto, M. Yamamoto, N. Akiyama, M. Fujita (Japan) P 4.017 Predictors of normal and abnormal outcome in clinical brain dopamine transporter imaging E. Jaakkola, J. Joutsa, V. Kaasinen (Finland) P 4.018 Iodine-123-FP-CIT SPECT in familial parkinsonism S. Onuma, K. Hasegawa, S. Nakamura, E. Horiuchi (Japan) P 4.019 Dopaminergic dysfunction and cognitive impairment in Parkinson’s disease: evidence from a SPECT study in a large cohort of de-novo patients D. Frosini, M. Giuntini, C. Pagni, E. Del Prete, G. Tognoni, D. Volterrani, U. Bonuccelli, R. Ceravolo (Italy) P 4.020 Fatigue in Parkinson’s disease and striatum dopamine transporter scan (DaTscan) uptake A. Sauerbier, P. Martinez-Martin*, M. Politis, A. Rizos, N. Trojanovic, N. Mulholland, G. Vivian, B. Corcoran, D. Trivedi, L. Perkins, R. Inniss, T. Chiwera, R. Barreto, M. Parry, A. Martin, N. Dimitrov, R. Brown, K. Ray Chaudhuri (United Kingdom, *Spain) P 4.021 The MIBG scintigraphy and DAT SPECT contribute to the diagnosis of PD and other related disorders, and evaluations of the course and stage of PD S. Tada, R. Ando, H. Iwaki, T. Tsujii, Y. Yabe, N. Nishikawa, M. Nagai, M. Nomoto (Japan) P 4.022 Characteristic metabolic brain pattern in Slovenian Parkinson’s disease patients P. Tomse, R. Tomaz, Z. Pirtošek , Y. Ma*, D. Eidelberg*, M. Trost (Slovenia, *USA) P 4.023 Features neuroimaging and neurological disorders in Alzheimer’s disease with parkinsonism D. Tolibov, G. Rakhimbaeva (Uzbekistan) P 4.025 Can Quantitative EEG (QEEG) differentiate patients with Parkinson’s disease (PD) from healthy controls? M. Chaturvedi, F. Hatz, A. Meyer, V. Cozac, U. Gschwandtner, V. Roth, P. Fuhr POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER P 4.011 71 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER 72 P 4.026 Synaptic homeostasis in Parkinson’s disease: an high-density EEG study in different stage of the disease V. Trendafilov, S. Sarasso*, J. Moeller, C. Staedler, A. Kaelin-Lang, S. Galati (Switzerland, *Italy) P 4.027 Nigrostriatal dopamine-independent resting-state functional networks in Parkinson’s disease P.H. Lee, J.S. Baik, Y.H. Sohn (South Korea) P 4.028 Brain network changes in relation to beginning apathy in PD patients F. Hatz, A. Meyer, U. Gschwandtner, P. Fuhr (Switzerland) P 4.029 Functional connectivity underpinnings of fatigue in “drug-naïve” patients with Parkinson’s disease A. Giordano, A. Tessitore, R. De Micco, G. Caiazzo, A. Russo, M. Cirillo, F. Esposito, G. Tedeschi (Italy) P 4.030 Classification of early stage Parkinson’s disease in EEG and tremor time-frequency features space O. Sushkova, Y. Obukhov, I. Kershner, A. Karabanov, A. Gabova (Russia) P 4.031 Correlation of the EEG frequency with cognitive performance in Parkinson’s disease - Six-months follow-up V. Cozac, M. Chaturvedi, F. Hatz, A. Meyer, K. Nowak, U. Gschwandtner, P. Fuhr (Switzerland) P 4.032 Alertness as assessed by clinical testing and alpha reactivity does not correlate with executive function decline in Parkinson’s disease (PD) R. Sturzenegger, A. Meyer, M. Chaturvedi, V. Cozac, F. Hatz, U. Gschwandtner, P. Fuhr (Switzerland) P 4.033 EEG features of dyskinesias, complicated by levodopa therapy in patient with Parkinson’s disease U. Askhonov, B. Gafurov, G. Ashanov (Uzbekistan) P 4.034 Polysomnographic features of REM sleep behavior disorder with or without Parkinson’s disease C. Ha, E. Bae (South Korea) P 4.035 Electromyographic diagnostics of Parkinson’s disease and detection risk groups among relatives of patients D. Ayupova (Uzbekistan) P 4.036 Identification of the globus pallidus interna based on time patterns analysis in Parkinson’s disease D.S. Andres, C. Daniel*, M. Merello* (Switzerland, *Argentina) P 5.001 Mayo Clinic Florida Morris K. Udall. Center of excellence for Parkinson’s research A. Strongosky, R. Rademakers, O. Ross, R. Uitti, J. Van Gerpen, Z.K. Wszolek, D. Dickson (USA) P 5.002 Epigenetics role in Parkinson’s disease M. Dehbashi, M. Rouigari (Iran) P 5.003 Identification of novel PD genes by whole-exome sequencing in Italian families L. Straniero, G. Soldà, R. Asselta, I. Guella*, G. Pezzoli, M. Farrer*, S. Goldwurm, S. Duga (Italy, *Canada) P 5.004 Antioxidant kinase inhibitors for LRRK2 Parkinson’s disease P. Sharan, D.C. Angeles, P. Ho, B.W. Dymock, K. Lim, E. Tan (Singapore) XXI World Congress on Parkinson’s Disease and Related Disorders LRRK2 and GBA mutation analysis in a cohort of Italian familial and sporadic PD I. Trezzi, V. Melzi, G. Franco, L. Borellini, E. Monfrini, N. Bresolin, G.P. Comi, A. Di Fonzo (Italy) P 5.007 I2020T LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway E. Ohta, T. Nihira, A. Uchino, Y. Imaizumi, Y. Okada, W. Akamatsu, K. Takahashi, M. Nagai, M. Ohyama, M. Ryo, M. Ogino, S. Murayama, A. Takashima, K. Nishiyama, Y. Mizuno, H. Mochizuki, F. Obata, H. Okano (Japan) P 5.008 Neuropsychological assessment in patients with Parkinson’s disease associated with PARK2 gene mutations: a case-control study P. Amami, C. Bagella, A. Elia, C. Barzaghi, B. Garavaglia, A. Albanese (Italy) P 5.010 Cytogenetic study and compared with measurements of oxidative stress and PINK1 gene in Parkinson’s disease (PD) patients J. Pichai Fenn, D. Shanwaz, S. Keshavarao, B. Vellingiri (India) P 5.011 DNAJC6 mutations associated with early-onset Parkinson’s disease S. Olgiati, M. Quadri, M. Fang, J.P. Rood, J.A. Saute*, H.F. Chien*, C.G. Bouwkamp, J. Graafland, M. Minneboo, G.J. Breedveld, J. Zhang***, F.W. Verheijen, W. Mandemakers, A.J. Boon, A.J. Kievit, L.B. Jardim*, E.R. Barbosa*, C.R. Rieder*, K.L. Leenders, J. Wang**, V. Bonifati (The Netherlands, *Brazil, **China) P 5.012 Novel compound heterozygous mutations of PLA2G6 in a Korean pedigree of young-onset Parkinson’s disease: a study of whole genome sequencing E.J. Choi, W. Lee, J. Shin, J. Seo, C.S. Lee (South Korea) P 5.013 Evaluation of genetic load in early-onset Parkinson’s disease patients by next-generation sequencing A. Seresini, T. Brambilla, C. Siri, G. Sacilotto, M. Zini, G. Pezzoli, M. Seia, S. Goldwurm (Italy) P 5.014 Association of TNF-alpha and IL-1beta genes polymorphism in Parkinson’s disease M. Subramanium, S. Keshavarao*, I. Kim (South Korea, *India) P 5.016 Polymorphisms of dopamine receptor genes are associated to increased risk of visual hallucinations in Italian Parkinson’s disease patients C. Comi, M. Ferrari, F. Marino, G. Riboldazzi, S. Rosa, R. Cantello, G. Bono, M. Cosentino (Italy) P 5.017 Evaluation of clinical phenotypes associated with cytogenetic effects and Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in Parkinson’s disease in Coimbatore region, South India M. Iyer, M. Gomathi, D. Shanawaz, B. Vellingiri, S. Keshavarao (India) P 5.018 A Molecular And Genetic basis study in POLG mutation of MtDNA in Parkinson’s patients in South Indian population K.K. Alagamuthu, M. Shafi Ahammed Khan, Y. Mohd, P. Krishnan, S. Keshvarao, B. Vellingiri (India) POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER P 5.006 73 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER 74 P 5.019 Association of mortalin (HSPA9) and other mitochondria-related genes with the risk of Parkinson’s disease and Alzheimer’s disease S.J. Chung, M. Kim, H. Ryu, J. Kim, Y.J. Kim, K. Kim, S. You, S.Y. Kim, J. Lee (South Korea) P 5.020 Screening of spontaneous genomic alterations and p53 gene polymorphism in new onset of Parkinson’s disease J. Ramalingam, I. Mahalaxmi, M. Subramaniam, L. Thangamani, A. Meyyazhagan, B. Vellingiri (India) P 5.021 Identification and verification of novel FBXO7 interacting proteins W. Mandemakers, R. Masius, M. Minneboo, D. Dekkers, J. Demmers, M. Kros, V. Bonifati (The Netherlands) P 5.022 Defective glucocerebrosidase in GBA1 mutant Parkinson’s disease fibroblasts is rescued by chemical chaperone ambroxol through modulation of lysosomal factors G. Ambrosi, C. Ghezzi, R. Zangaglia, G. Levandis, C. Pacchetti, F. Blandini (Italy) P 5.023 “Benign” GBA variants may alter gene splicing in South African Parkinson’s disease cases M. Barkhuizen, D.G. Anderson, F.H. Van Der Westhuizen, A.F. Grobler (South Africa) P 5.024 Epigenome-wide DNA methylation analysis in brothers and monozygotic twins discordant for Parkinson’s disease O. Kaut, I. Schmitt, S. Witt, J. Tost*, U. Wüllner (Germany, *France) P 5.025 DNA methylation status and LINE-1 expression in rat brain S. Mukherjee, K. Upadhyaya, D. Sharma (India) P 5.026 Caffeine intake and genetic susceptibility to Parkinson’s disease P. Sharan, E.K. Tan (Singapore) P 5.027 Interaction between a GWAS-linked genetic variant and caffeine intake in Parkinson’s disease Y.C. Cheng, M.H. Yong, E.K. Tan (Singapore) P 5.028 Interaction between caffeine intake and N-acetyltransferase 2 genotype in Parkinson’s disease J.W. Lim, M.H. Yong, J.C.J. Allen, S. Shenolikar, K.M. Prakash, E.K. Tan (Singapore) P 5.029 Systems biology analysis of the proteomic alterations in Parkinson’s disease: common and diseasespecific pathways T. Alberio, C. Monti, H. Bondi, I. Colugnat, L. Lopiano, A. Chiò, M. Fasano (Italy) P 5.030 Two new SCL20A2 mutations identified in two southern Italy families with primary familial brain calcification S. Scannapieco, M. Gagliardi, G. Annesi, M. Morelli, G. Iannello, G. Nicoletti, A. Gambardella, A. Quattrone (Italy) P 5.031 A novel nonsense CAMTA1 mutation presenting as a tremor predominant phenotype S. Agarwal, R. Gilbert, H. Lau (USA) P 5.032 Exome sequencing in a family with autosomal-recessive mental retardation, polyneuropathy, ataxia and epilepsy H. Hor, C. Wider (Switzerland) XXI World Congress on Parkinson’s Disease and Related Disorders Vanishing white matter disease and juvenile lateral sclerosis type 4: possibly a novel genetic and clinical overlap J. Good, F. Vingerhoets, C. Wider (Switzerland) P 5.034 Association of Parkinson’s disease (PD) with geterozygous carriers of the Wilson disease (WD) gene E. Ilyechova, T. Sankova, I. Milyukhina, M. Karpenko, L. Puchkova (Russia) P 5.035 Polymorphisms of genes of oxidative stress and glutamate excitotoxicity in patients with tardive dyskinesia in schizophrenia N. Nurmetov, O. Kurbanov, Z. Ibodullaev, D. Abdullaeva (Uzbekistan) P 5.036 Cytogenetic, genotypic, gene sequencing and gene expression studies on the stroke patients. A case control study R. Chandirasekar, K. Murugan, B. Lakshman Kumar, R. Jayakumar*, K. Sasikala (India, *Malaysia) P 5.037 Analysis of GABA and serotonin levels concordance with Vitamin D receptor gene (VDR) polymorphism in late onset Alzheimer disease (LOAD) M. Shafi Ahammed Khan, K. Alagamuthu, J. Ramalingam, P. Krishnan, Y. Mohd, B. Vellingiri (India) P 5.038 Cytogenetic biomarkers and molecular study of PS1 gene in Alzheimer’s disease in South Indian population L. Thangamani, A. Meyyazhagan, S. Keshavarao, B. Vellingiri (India) P 5.039 Identification of chromosomal alteration and association study of neuroligins and neurexins gene polymorphisms with Alzheimer’s disease (ad) patients in Coimbatore population, TamilNadu, India S. Srinivasan, A. Meyyazhagan, D. Shanwaz, B. Vellingiri (India) P 5.040 NcRNAs, Nutrition and Brain disorders M. Dehbashi, M. Rouigari (Iran) P 5.041 CREB expression in hippocampus of different age groups of wistar rats S. Sharma, S. Rajput (India) P 5.042 Toward a pharmacological control of gene therapy for Parkinson’s disease M. Humbert-Claude, A. Chtarto* (Switzerland, *Belgium) P 6.001 Safinamide differentially modulates glutamate release in the basal ganglia nuclei M. Morari, A. Brugnoli, C. Caccia, E. Melloni, G. Padoani, S. Vailati, M. Sardina (Italy) P 6.002 Safinamide and glutamate release: new insights E. Melloni, A. Brugnoli, C. Caccia, M. Morari, G. Padoani, S. Vailati, M. Sardina (Italy) P 6.003 Restoration of biochemical, behavioral and ultrastructural changes in aging rat brain: neuroprotective role of 17β -estradiol P. Kumar, R.K. Kale, N.Z. Baquer (India) P 6.004 4i (N-(3-Chloro-2-methylphenyl) quinoxalin-2-carboxamide), a novel 5-HT3 receptor antagonist alleviates depressive behavior evoked in streptozotocin-induced diabetic mice: role of oxidative stress D. Gupta, M. Radhakrishnan (India) POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER P 5.033 75 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER 76 P 6.005 Functional connectivity changes in gait related neural network in PD with freezing of gait M. Mihara, Y. Watanabe, K. Konaka, H. Otomune, H. Fujimoto, H. Mochizuki (Japan) P 6.006 Neuroprotective effects of Withania Someniferais on mice brain: a therapeutic potential drug for Parkinson’s disease V. Sharma, L. Singh (India) P 6.007 Effect of electroconvulsive therapy on visuospatial memory in rats N. Lakkappa, P. Thaggikuppe Krishnamurthy (India) P 6.008 Anti-aging and neuro-protective effects of syzygium cumini (Jambolan) extract on spatial learning and memory of aging male rats P. Pandey, S.F. Bashir (India) P 6.010 Ameliorative effects of 1,3,4-thiadiazole derivatives on scopolamine induced cognitive deficits in mice A. Kulshreshtha, P. Piplani (India) P 6.011 Effect of combination therapy of caffeinated coffee and selective 5-HT4 agonist, prucalopride, in an Alzheimer’s disease mouse model: possible implications on Amyloid Beta formation N. Al-Shehaby, L. Mahran, K. Abou-Aisha, M. Rady, N. El-Sayed (Egypt) P 6.012 Possible involvement of janus kinase-signal transducers and activators of transcription (JAK/STAT) signaling pathway in vitamin e-mediated anti-depressant-like effects in a rat depression model N. Alrasheed, M. Al-Samhari, S. Al-Rejaie, R. Ahmed, N. Dzimiri (Saudi Arabia) P 6.013 The mutation causing the motor and behavioral disorders in white mice O. Turgunkhujaev, R. Matmurodov, N. Tolibova, M. Khanova, Z. Absaitov (Uzbekistan) P 6.014 Genetic models of Parkinson’s disease M. Dehbashi, M. Rouigari (Iran) P 6.015 Progressive axonal degeneration of the striatonigral dopaminergic neurons in calcium-independent phospholipase A2β-knockout mice G. Beck, K. Shinzawa, H. Sumi-Akamaru, H. Mochizuki (Japan) P 6.016 c-Rel deficient mice, a mouse model of “spreading” PD-like pathology E. Parrella, A. Bellucci, V. Porrini, A. Lanzillotta, M. Benarese, G. Vegezzi, C. Baiguera, A. Antonini, P.F. Spano, M. Pizzi (Italy) P 6.017 Neurodegeneration of the dopaminergic neurons due to the inhibition of platelet-derived growth factor receptors (PDGFR) In Zebrafish Larvae A. Norazit, D. Wong, N. Abdul Halim, S. Mohd Noor (Malaysia) P 6.018 Integration of cortical and basal ganglia inputs in motor thalamus of parkinsonian animal models G. Orban, W. Song, A. Kaelin-Lang, S. Galati (Switzerland) P 6.019 Role of brain neurotransmitters in Parkinson’s induced rats N. Kumar, R.K. Khanna (India) P 6.020 Spreading depression susceptibility is reduced in parkinson rat model M. Lotfinia (Iran) XXI World Congress on Parkinson’s Disease and Related Disorders The hippocampal serotonin system is related with the antidepressant effect of sertraline, venlafaxine, nortriptyline and L-tryptophan in the 6-OHDA-lesioned rats M. Vital, Z. Thiago, M. Meira Santos Lima, C. Da Cunha, R. Andreatini, R. Santiago (Brazil) P 6.022 Weak static magnetic field exposure blocks 6-hydroxydopamine (6-OHDA)-induced neuronal degeneration R. Uzan-Gueta, L. Schachter, Y. Loboda, J. Finberg (Israel) P 6.023 High fat diet feeding exacerbates the toxic effects of 6-hydroxydopamine in rats: Possible involvement of histone acetylation S. Sharma, R. Taliyan (India) P 6.024 Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson’s disease A. Michel, P. Downey, J. Nicolas, D. Scheller (Belgium) P 6.025 Opioid K receptor variant delays the onset of dyskinesias in Parkinson’s disease R. Cilia, R. Asselta, R. Benfante, E. Cereda, D. Vallauri, L. Marabini, D. Fornasari, S. Goldwurm, G. Pezzoli (Italy) P 6.027 Symptomatic and biochemical assessments using microdialysis method of an antidyskinetic compound in a L-DOPA induced dyskinesias rat model S. Robelet, V. Girod, D. Revy, B. Audrey, B. Adeline (France) P 6.028 Increased serotonin innervation of the sensorimotor striatum in a primate model of Parkinson’s disease D. Gagnon, T. Di Paolo, M. Parent (Canada) P 6.029 Design and synthesis of coumarin based dual binding acetylcholinesterase inhibitors for the treatment of cognitive dysfunction S. Shaffali, P.P. Piplani (India) P 6.030 Increased density of large calretinin expressing interneurons in the striatum of parkinsonian monkeys S. Petryszyn, M. Parent (Canada) P 6.032 Phosphorylation by okadaic acid enhances MPP+ induced hydroxyl radical generation in rat striatum T. Obata, M. Nakajima (Japan) P 6.033 Studying pain-related manifestations in an MPTP-induced rat model of Parkinson’s disease M. Padurariu, A. Ciobica, R. Lefter, E. Anton (Romania) P 6.034 Exercising is reducing anxiety, depression and memory deficits induced by a MPTP-induced rat model of Parkinson’s disease A. Ciobica, M. Padurariu, R. Lefter, E. Anton (Romania) P 6.035 Computer aided movement analysis of MPTP mouse on inverted horizontal grid W. Niewiadomski, E. Palasz, M. Skupinska, M. Zylinski, M. Steczkowska, A. Gasiorowska, G. Niewiadomska, G. Riedel* (Poland, *United Kingdom) P 6.036 Rolipram, a PDE-IV inhibitor protects against experimental Parkinsonism in mice N. Kumar, R.K. Khanna (India) POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER P 6.021 77 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER 78 P 6.037 Crossbreeding two mice strains with differential susceptibility to 1-Methyl-4-Phenyl-1,2,3,6Tetrahydropyridine (MPTP) positively modulates nigral dopaminergic phenotype D.J. Vidyadhara, H. Yarreiphang, T.R. Raju, P. Anand Alladi (India) P 6.038 Nigrostriatal degeneration dictates a top-down genetic program for neuroplasticity and neurorepair: focus on the hippocampus and Wnt/GSK-3β/β-catenin signaling cascade B. Marchetti, F. L’Episcopo, C. Tirolo, N. Testa, M.F. Serapide (Italy) P 6.039 Distribution, metabolism and elimination of opicapone in the rat and non-human primates A.I. Loureiro, C. Fernandes-Lopes, P. Soares-da-Silva (Portugal) P 6.040 Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat D. Gonçalves, G. Alves, A. Fortuna, P. Soares-da-Silva, A. Falcão (Portugal) P 6.041 Opicapone improved the effect of L-DOPA on the MPTP-induced Parkinson’s-like syndrome in cynomolgus monkeys M.J. Bonifacio, F. Sousa, S. Medakkar*, J. Vivian*, P. Soares-da-Silva (Portugal, *Singapore) P 6.042 Opicapone improves the levodopa induced rotational behavior in 6-OHDA hemiparkinsonian rats E. Moura, M.J. Bonifacio, P. Soares-da-Silva (Portugal) P 6.043 Perinatal arsenic exposure alters central dopaminergic system of rats L.P. Chandravanshi, R. Gupta*, R.K. Shukla, V.K. Khanna, S.K. Trigun (India) P 6.044 Role of dopaminergic receptors and post synaptic signaling in arsenic induced neurotoxicity: ameliorative effect of curcumin P. Srivastava, Y. Dhuriya, R. Gupta, R. Shukla, A.B. Pant, V.K. Khanna (India) P 6.045 Evidence of heavy metals implication in Parkinson’s disease: involvement of serotonin and the beneficial therapeutic role of curcumin H. Benammi, O. El Hiba, H. Gamrani (Morocco) P 6.046 Experimental model of extrapyramidal disorders caused by reserpine D. Tursunov (Uzbekistan) P 6.047 Exogenous salsolinol influences gut-brain axis M. Kurnik, K. Gil, M. Białas, V. Aleksandrovych, A. Bugajski, P. Thor (Poland) P 6.048 Characterization of the lipopolysaccharide induced model of Parkinson’s disease: role of oxidative stress and neuroinflammation N. Sharma, B. Nehru (India) P 6.049 Antiparkinson and antioxidant effect of pyridylpyrazolinyl substituted heterosteroids in LPS induced neuroinflammation model of neurodegenerative disorders R. Singh, R. Bansal (India) P 6.050 Apocyanin, a microglial NADPH oxidase inhibitor prevents dopaminergic neuronal degeneration in lipopolysaccharide induced Parkinson’s disease model N. Sharma, B. Nehru (India) P 6.051 Bacopa monnieri supplements offset motor and co-morbid behavioral pathology, oxidative impairments and neurotoxicity in an chronic environmental toxin model of Parkinson’s disease in mice G. Krishna, R. Hosamani*, M. Muralidhara (India, *USA) XXI World Congress on Parkinson’s Disease and Related Disorders Neuroprotective effect of ethanolic extract of Pandanus odoratissimus Ln. to Paraquat mice model of Parkinson’s disease E.C. Sitepu, R. Adji, A.K. Tedja, S. Simanjaya (Indonesia) P 6.053 Alteration of striatal tetrahydrobiopterin in iron-induced unilateral model of Parkinson’s disease B. Aryal (Nepal) P 6.054 Copper poisoning induces neurobehavioral features of Parkinson’s disease in rat: alters dopaminergic system and locomotor performance A. Abbaoui, O. El Hiba, H. Gamrani (Morocco) P 6.055 Deciphering the mechanism of cadmium induced brain dopaminergic dysfunctions and assess the protective potential of quercetin in rats R. Gupta, R.K. Shukla, L.P. Chandravanshi, P. Srivastava, Y. Dhuriya, A.V. Pant, V.K. Khanna (India) P 6.056 The protective effect of curcumin on dopaminergic system after chronic aluminum intoxication: possible link with Parkinson’s disease W. Laabbar, A. Elgot, H. Gamrani (Morocco) P 6.057 Origin of α-mannosidase in CSF A. Tasegian, S. Paciotti, M.R. Ceccarini, M. Codini, T. Moors, D. Chiasserini, E. Albi, W.D. Van De Berg*, L. Parnetti, T. Beccari (Italy, *The Netherlands) P 6.058 Synapsin III alterations in Parkinson’s disease A. Bellucci, M. Zaltieri, F. Longhena, G. Faustini, J. Grigoletto, G. Favero, S. Castrezzati, R. Rezzani, M. Pizzi, F. Benfenati, M.G. Spillantini*, C. Missale, P. Spano (Italy, *United Kingdom) P 6.059 Understanding the differential regulation of GBA and GBAP1 expression V. Rimoldi, G. Rovaris, L. Straniero, G. Pezzoli, S. Goldwurm, G. Soldà, R. Asselta, S. Duga (Italy) P 6.060 Astrocytes and microglia: new insights in oxidative metabolism of dopamine A. De Iuliis, L. Facci, S. Skaper, G. Arrigoni, M. Plebani, P. Giusti, A. Antonini (Italy) P 6.061 Structural analysis of alpha-synuclein oligomers via antibody fingerprinting L. Nilsson, T. Islam, I. Iakovleva, K. Brännström, A. Olofsson (Sweden) P 6.062 Deregulation of miRNAs 103a, 30b and 29a in peripheral blood of L-dopa treated Parkinson’s patients A. Serafin*, L. Foco*, S. Zanigni*, H. Blankenburg*, A. Picard*, A. Zanon*, G. Giannini*, I. Pichler*, M.F. Facheris*, P. Cortelli*, P.P. Pramstaller*,°, A.A. Hicks*, F.S. Domingues*, C. Schwienbacher* (*Italy, °Germany) P 6.063 An experimental study of transplantation of human amniotic epithelial cells in the corpus striatum of Parkinson’s induced wistar albino rats P. Ravisankar (India) P 6.064 Inhibition of PERK and NFKB pathway can reduce death of stressed dopaminergic neurons differentiated from human stem cell line Z.L. Chaudhry, B. Ahmed (United Kingdom) P 6.065 Oral intake of anti-hangover substance increases aldehyde dehydrogenase activity: new preventive and therapeutic potentials for oxidative neuronal injury? C. Bang, B. Kang, S. Choung, K. Choi (South Korea) POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER P 6.052 79 XXI World Congress on Parkinson’s Disease and Related Disorders POSTER SESSION 3 - WEDNESDAY, 9 DECEMBER 80 P 6.066 Blocking mitochondrial fission is protective in dopaminergic neuronal cells with inducible α-synuclein expression R.Z. Fan, K. Tieu (United Kingdom) P 6.067 A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson’s disease C. Choong, T. Sasaki, T. Yasuda, H. Hayakawa, K. Baba, Y. Hirata, S. Uesato, H. Mochizuki (Japan) P 6.068 IL-1beta induces MMP-9 expression associated with cell migration via NOX2-derived ROS signals in rat brain astrocytes C. Yang, P. Yu (Taiwan) P 6.069 Effect of metal ions on aggregation of amyloid beta peptide Z. Abbaskhani (Iran) P 6.070 Presenilins mutations within moroccan cases with Alzheimer disease N. El Kadmiri (Morocco) XXI World Congress on Parkinson’s Disease and Related Disorders Alonso Recio L., 52 Alrasheed N., 76 Altmann V., 29, 56 Alvarez-Avellon T., 65, 71 Alves G., 78 Amami P., 73 Ambhore N., 57 Amboni M., 58 Ambrosi G., 41, 74 Amirjanyan H., 46, 64, 66, 67 Anand S.S., 56 Anand Alladi P., 78 Anderson D.G., 74 Ando R., 39, 61, 71 Andreatini R., 77 Andreoli R., 45 Andres D.S., 41, 72 Andrzejewska R., 65 Angeles D.C., 72 Annesi G., 74 Anton E., 77 Antonini A., 26, 30, 33, 40, 44, 48, 51, 52, 53, 57, 58, 60, 63, 76, 79 Aquila F., 65 Arabia G., 46 Arai A., 56 Arciniega-Martinez G., 48 Arciniega-Martinez G.G., 51 Argaud S., 22, 52 Argyropoulou M., 70 Arkha Y., 62 Arrigoni G., 79 Arruda W., 67, 69, 70 Aryal B., 79 Arzberger T., 34, 66 Asaadi S., 61 Asahara T., 45 Ascherio A., 62 Aschermann Z., 22, 32, 52, 57, 61, 66 Ashanov G., 41, 72 Ashizawa T., 69 Ashrafi F., 61 Askhonov U., 41, 72 Asselta R., 36, 39, 41, 72, 77, 79 Astrakas L., 70 Ataniyazov M., 64 Audrey B., 77 Auffret M., 35, 59 Avagyan G., 46, 64, 66, 67 Ayan C., 50, 54 Ayupova D., 41, 72 Azimov A., 67 Azizova O., 67 Azulay J.-P., 30 Azulay J., 27, 57 Azzaro C., 20, 45 B Ba E.H.M., 47 Baba K., 80 Bader B., 34, 66 Badoud S., 62 Bae E., 72 Bagella C., 73 Baiguera C., 44, 76 Baik J.S., 72 Bakshi R., 62 Balás I., 32, 61, 66 Balboa-Alegría L.F., 51 Balestrino R., 61 Balint B., 63 Ballard C., 57 Banerjee R., 56 Bang C., 44, 79 Bansal R., 44, 78 Baquer N.Z., 75 Barbagli D., 70 Barbosa E.R., 41, 73 Barcelon E., 59 Barkhuizen M., 74 Barlow D.H., 55 Baroncini D., 61 Barone P., 21, 27, 42, 52, 96 Barreto R., 30, 39, 47, 49, 59, 71 Bartolomei L., 58 Barzaghi C., 27, 34, 48, 66, 73 Bashir S.F., 76 Basse A.M., 47 Bassetti C., 28 Batisti J.P., 67 Battacharyya K.B., 30 Battenberg F., 62 Baumann C., 28, 47, 49 Bebitov S., 65 Beccari T., 63, 79 Beck G., 76 Begaj I., 46 Beghi E., 60 Behari M., 69 Belay S., 70 Bellucci A., 44, 76, 79 Beltramini M., 56 Benammi H., 78 Benarese M., 44, 76 Benazzouz A., 32, 61 Benedetto N., 65 Benesh J., 29, 39, 57, 58 Benfante R., 39, 77 Benfenati F., 79 Benoist A., 60 Benomar A., 66 Bentivoglio A.R., 27, 52 Berardelli A., 28, 36 Bergmann L., 30, 57, 58 Beridze M., 65 Bernabei R., 20, 22, 48, 51 Bertholdo D., 67 Bertozzi V., 20, 45 Bestetti A., 20, 49 Bhatia K., 33, 42 , 63 Bhatia K.P., 67 Bhattacharyya K.B., 30 Bhidayasiri R., 40 Biagioni M., 53, 62, 70 Białas M., 78 Bianchi E., 60 Bilbault T., 32, 59, 60 Biller T., 67 Biosa A., 56 Birouk N., 66 Bisaglia M., 56 Biscetti L., 46 Bitsara C., 49 Biundo R., 33, 52, 53, 63 Bjorklund A., 23 Black K., 57 Blandini F., 38, 41, 74 Blankenburg H., 79 Bloch J., 62 Bloem B.R., 30 Blume J., 32, 60 Bodis-Wollner I., 40 Bogdahn U., 32, 60 NAME INDEX A Aarsland D., 24, 42 Ababou N., 50 Abbaoui A., 64, 79 Abbaskhani Z., 80 Abbruzzese G., 26, 30, 48 Abdukadirova I., 64 Abdul Halim N., 76 Abdullaeva D., 64, 66, 75 Abdullayeva D., 64 Abdulmassih E., 69 Abe K., 58, 71 Abler V., 56 Abou-Aisha K., 76 Absaitov Z., 76 Ács P., 57 Adeline B., 77 Aderkichi M., 50 Adji R., 79 Adler C., 29, 35, 36 Agan Yildirim K., 66 Agarwa S., 62 Agarwal S., 70, 74 Agro A., 32, 59, 60 Aguggia M., 58 Ahmed B., 44, 79 Ahmed R., 76 Ahn J., 51, 62 Ahn J.Y., 49 Ahn T., 66 Ahn Y., 65 Aiba I., 64 Ait Benhaddou E., 66 Akamatsu W., 73 Akiyama N., 71 Al-Rejaie S., 76 Al-Samhari M., 76 Al-Shehaby N., 76 Alagamuthu K., 75 Alagamuthu K.K., 73 Albanese A., 27, 36, 37, 48, 73 Albani G., 20, 45 Alberio T., 74 Albertini G., 25, 54 Albi E., 79 Alcacer C., 56 Aleksandrovych V., 78 Alimonti D., 65 Allen J.C.J., 74 81 XXI World Congress on Parkinson’s Disease and Related Disorders NAME INDEX 82 Bogdanov R., 71 Bologna M., 22, 51 Bonanni L., 48 Bondi H., 74 Bonifacio M.J., 78 Bonifati V., 18, 25, 34, 41, 66, 73, 74 Bonizzoni E., 58 Bono F., 46 Bono G., 73 Bonuccelli U., 24, 43, 65, 71 Boon A.J., 41, 73 Borellini L., 73 Borges C.M., 67 Borghammer P., 49 Borghese M.C., 26, 55 Borgognon S., 62 Borgohain D.R., 61 Borgohain R., 60, 62 Borisova S., 71 Bosetti P., 22, 53 Bostantjopoulou S., 49 Bötzel K., 50, 62 Bour L., 61, 65 Bour L.J., 61 Bouwkamp C.G., 41, 73 Bove F., 27, 52 Brambilla T., 73 Branco Germiniani F.M., 64, 67 Brandi V., 20, 22, 48, 51 Brännström K., 79 Breedveld G.J., 34, 41, 66, 73 Bresolin N., 63, 73 Bril E., 30, 57 Brito R.N., 67 Broderick D., 68 Brooks D.J., 21 Brosnan M., 54 Brown M., 26, 56 Brown P., 38 Brown R., 39, 71 Brücke T., 18 Brugnoli A., 75 Brühlmann S., 54 Brunet J., 62 Brusa L., 52 Brys M., 62, 67, 70 Buated W., 26 , 50, 55 Bubacco L., 56 Bucior E., 46 Bugajski A., 78 Bulut B., 66 Burn D., 57 Burns J., 67 Busà M.G., 20, 49 Busse M., 54 C Cabrera A., 70 Caccia C., 75 Caiazzo G., 41, 72 Cakmak V.A., 66 Calabresi P., 28, 46 Calamuneri A., 67 Calandrella D., 35, 39, 58 Caldara M., 65 Callegari-Jacques S., 29, 56 Calne S.M., 40 Calzetti S., 22, 45, 50 Campolo J., 27, 45 Cancela Carral J.M., 50, 53, 54 Canesi M., 52 , 58 Canever M., 67 Cantello R., 73 Caporali A., 51 Cardoso F., 21, 24, 33 Carecchio M., 34, 66 Carreon-Bautista E.E., 51 Carroll C., 48 Carrozzini D., 48 Carta A.R., 35, 62 Castilla De Cortazar Larrea I., 59 Castrezzati S., 79 Casula C., 25, 54 Cattaneo C., 58 Cavaco S. Cavallo M., 60 Cavandoli C., 60 Ceballos-Baumann A., 50 Ceccarini M.R., 79 Cembrani F., 20, 45 Cenci A., 56 Cenci Nilsson A.M., 28, 38 Ceravolo M.G., 58 Ceravolo R., 44, 52, 58, 65, 71 Cereda E., 39, 77 Cervantes-Arriaga A., 48, 51 Chabardes S., 62 Chahidi A., 64 Chan L.L., 39, 70 Chandirasekar R., 45, 75 Chandravanshi L.P., 78, 79 Chang M., 47 Chatagny P., 62 Chatamra K., 29, 30, 39, 57, 58 Chatterjee K., 56 Chatterjee P., 56 Chatterjee S., 56 Chaturvedi M., 22, 25, 26, 41, 53, 55, 71, 72 Chaudhry Z.L., 44, 79 Chaudhuri K.R., 35, 46, 47, 49, 57, 59 Chaudhuri R., 30, 59 Chavez-Oliveros M., 48 Chekeeva N., 48 Chen J., 22, 52 Cheng Y.C., 74 Cheon S., 49 Cherninskyi A., 46 Chi-Burris K., 27, 57 Chiasserini D., 46, 63, 79 Chien H.F., 41, 73 Chillemi G., 67 Chiò A., 74 Chiwera T., 39, 47, 48, 49, 71 Cho J., 69 Cho J.W., 20, 50 Choi W., 71 Choi E.J., 73 Choi K., 44, 79 Chondrogiorgi M., 65, 70 Choong C., 80 Choudhry A., 56 Choudhury S., 56 Choung S., 44, 79 Chraa M., 64 Christopher R., 45 Chrobak A., 60 Chung S.J., 62, 74 Cilia R., 29, 32, 34, 39, 52, 77 Cimolin V., 20, 45 Ciobica A., 77 Cirillo M., 41, 72 Cisse O., 20, 45, 47 Clarke C.E., 46, 53 Coate B., 57 Codini M., 79 Coletti M., 58 Colombo A., 52 Colombo C., 20, 49 Colosimo C., 21, 33, 37, 38 Colugnat I., 74 Comi C., 73 Comi G., 61 Comi G.P., 63, 73 Constans J.M., 60 Contarino F., 38, 61 Contarino M.F., 61 Contin L., 20, 45 Contri P., 47 Corbett A., 57 Corcoran B., 39, 71 Corona F., 25, 54 Correa-Basurto J., 59 Cortelli P., 27, 28, 31, 48, 58, 63, 79 Corti S., 63 Cosentino M., 73 Cossu G., 58 Costa R.M., 28 Cottet J., 62 Cova I., 47 Cozac V., 41, 71, 72 Cozzi L., 27, 45 Crippa A.C., 69 Criscuolo C., 27, 52 Cronin-Golomb A., 55 Crucianelli L., 39, 68 Cucca A., 62 Cuetos Vega F., 71 Curry S., 46 Cybulski G., 48, 53, 54 Czerwosz L., 39, 69 D D’Avella R., 26, 55 Da Cunha C., 77 Da Lio M., 22, 53 Dacpano G., 62 Dadah S.M.L., 47 Dadajonov S., 67 XXI World Congress on Parkinson’s Disease and Related Disorders Dimitrov N., 39, 71 Diop A.G., 20, 45, 47 Diop A.M., 20, 45, 47 Diop M.S., 20, 45, 47 Dizdar N., 58 Djalilova S., 64 Domagk D., 30, 58 Domingues F.S., 79 Dowling F., 46 Downey P., 36, 77 Drapier S., 35, 59 Dressler D., 37 Dubow J., 29, 32, 57, 59, 60 Duga S., 36, 41, 79, 72 Dumitru M.M., 51 Duprez J., 22, 52 Dürr A., 21, 40 Dutkiewicz J., 32, 50, 61 Dutra B.G., 63 Duyckaerts C., 65 Dymock B.W., 72 Dzimiri N., 76 Dzyngel B., 32, 59, 60 E Eaton S., 29, 39, 57, 58 Edwards M., 22, 42, 43, 51, 52 Edwards M.J., 39, 68 Eidelberg D., 39, 71 El Hiba O., 64, 78, 79 El Kadmiri N., 80 El Khamlichi A., 62 El Ouahabi A., 62 El-Ad B., 46 El-Sayed N., 76 Eleopra R., 58, 60 Elgot A., 79 Elia A., 20, 22, 25, 27, 73 Elia A.E., 27, 48 Eliaz R., 56 Englund E., 63 Erro R., 22, 51, 63, 67 Escobar-Barrios M.S., 51 Esmail S., 54 Espay A., 39, 58 Espay A.J., 28, 33 Esposito F., 41, 72 Eusebi P., 46, 63 Evangelou E., 65 Evison F., 46 Eyal E., 56 F Fabbrini G., 34, 58, 66 Facci L., 79 Facheris M.F., 79 Faggiani E., 32, 61 Falcão A., 78 Falup-Pecurariu C., 48, 49, 52 Fan R.Z., 80 Fang M., 41, 73 Farah M., 69 Farangis Bonu D., 71 Farombi T., 20, 50 Farotti L., 46 Farrer M., 41, 72 Faruq M., 69 Faryniuk J.H., 69 Fasano A., 22, 27, 37, 38, 43, 51, 52 Fasano M., 74 Fatterpekar G., 67 Faustini G., 79 Favero G., 79 Faye A.B., 20, 45 Fazzi L., 63 Fedorova N., 30, 57 Fedorova T., 49 Fera F., 46 Ferini-Strambi L., 28 Fernandes J., 52 Fernandes-Lopes C., 78 Ferrari G., 20, 45 Ferrari M., 73 Ferrari S., 20, 45 Ferraris C., 20, 45 Ferreira J., 27, 57, 59 Fezza J., 67 Fichera M., 61 Fieblinger T., 56 Fietzek U., 50 Figura M., 46 Finberg J., 77 Fiorenzato E., 20, 52, 63 Fiszer U., 45, 60 Fitzgerald K., 62 Fiuza Parolin L., 67 Foco L., 79 Fogang F.Y., 47 Foltynie T., 22, 52 Foncke E., 35, 62 Fonseca V.R., 69 Fornasari D., 39, 77 Fortuna A., 78 Fortunato F., 63 Fouad M., 64 Fragola M., 32, 61 Fraix V., 62 Franco G., 73 Franzin A., 61 Frattini E., 63 Fratto A., 46 Fregosi M., 62 Friedman A., 34, 39, 46, 50, 61, 70 Friedman J., 57 Friedman J.H., 40 Frosini D., 71 Fuhr P., 22, 22, 25, 26, 41, 51, 53, 55, 71, 72 Fujimoto H., 76 Fujinami T., 26, 50, 55 Fujioka S., 46, 65 Fujita M., 58, 71 Fukada K., 58 Fukae J., 46, 65 Fulchieri M., 48 Funamizu Y., 56 Furgała A., 60 Fusco D., 22, 51 NAME INDEX Dahdal P., 22, 53 Daini R., 51 Dam-Larsen S., 30, 58 Damásio J., 52 Danek A., 34, 66 Daniel C., 41, 72 Danielsen E.H., 49 Dansie Bacci E., 30, 58 Daoudi S., 50 Davis M., 56 De Bie R.M., 60 De Bie R.M.A., 61 De Cecco M., 22, 53 De Iuliis A., 79 De Lipsis L., 53 De Maria R., 27, 45 de Mello Rieder C., 29, 56 De Micco R., 41, 72 De Palma G., 45 De Pandis M.F., 25, 54 De Vita P., 26, 55 Decesare J., 35, 59 Dehbashi M., 72, 75, 76 Dekkers D., 74 Del Gamba C., 65 Del Prete E., 71 Del Sorbo F., 27, 48 Delaville C., 32, 61 Deli G., 22, 32, 52, 57, 61, 66 Delli Pizzi S., 48 Demartini B., 39, 68 Demmers J., 74 Deszczynski J.M., 61 Devidze E., 65 Dhuriya Y., 44, 78, 79 Di Battista M.E., 47, 52, 53 Di Fonzo A., 63, 73 Di Michele G., 27, 52 Di Paolo T., 77 Di Rocco A., 53, 62, 70 Diaconu S., 49 Diagne N.S., 20, 45 Diatta A., 47 Dickson D., 72 Didour M., 50 Dietrichs E., 31 Diez-Cirarda M., 55, 70 Dijk J.M., 60 Dilettuso F., 26, 55 G Gabova A., 72 Gabrielyan I., 46, 64, 66, 67 Gafurov B., 41, 72 Gaglione M., 25, 54, 74 Gagnon D., 77 Galati S., 41, 44, 72, 76 Galazka-Friedman J., 39, 70 Galis Y., 35, 62 Galli M., 20, 25, 45, 54 Galli N., 67 Galvin J., 70 Gama H., 59 Gamaleya A., 30, 57 Gambardella A., 74 Gamrani H., 64, 78, 79 83 XXI World Congress on Parkinson’s Disease and Related Disorders NAME INDEX 84 Gangadharan S., 52 Garavaglia B., 27, 34, 48, 66, 73 Garcia-Magariño Alonso M., 59 Gasiorowska A., 48, 53, 54, 77 Gavrilov Y., 47 Gaye N.M., 20, 45, 47 Gazioglu S., 66 Gelosa G., 27, 45 Gentilini M., 20, 45 George L., 71 Gersel Stokholm M., 49 Geut A., 35, 62 Ghezzi C., 41, 74 Gholizadeh Ghozloujeh Z., 61 Ghorbani E., 32, 60, 61 Ghoshal A., 56 Giacomini P., 52 Giannini G., 32, 61, 79 Gianotti P.R.J.P., 63 Gil K., 78 Giladi N., 46 Gilbert R., 53, 74 Ginevrino M., 27, 52 Giordano A., 41, 72 Giovinazzo A., 32, 59, 60 Girlanda P., 67 Girod V., 77 Giuberti M., 20, 45 Giuntini M., 71 Giusti P., 79 Giyazitdinova E., 34, 45, 46, 47, 63, 64, 67 Go P.-W., 53 Godefroy O., 53, 60 Godena V.K., 56 Gogol A., 66 Goldoni M., 22, 50 Goldwurm S., 18, 36, 39, 41, 52, 72, 73, 77, 79 Gomathi M., 73 Gómez-Beldarrain M., 70 Gómez-Beldarrain M.Á., 55 Gómez-Esteban J.C., 55, 70 Gonçalves A., 52 Gonçalves D., 78 Gonzalez-Martinez A., 49 Good J., 75 Górecka-Mazur A., 60 Gorzoni M.L., 63 Goto Y., 62 Goyal V., 69 Graafland J., 34, 41, 66, 73 Gracheva E., 45, 50 Gramstad A., 29, 56 Grande G., 47 Grano M., 26, 55 Grassi E., 58 Gray R., 46 Gregier K., 50 Grigoletto J., 79 Grilo M., 47, 49 Grobler A.F., 74 Groppo E., 34, 66 Groth K., 58 Gschwandtner U., 22, 25, 26, 41, 51, 53, 55, 71, 72 Gualandi F., 34, 66 Gubareva N., 30, 57 Guella I., 41, 72 Guffanti G., 54 Guicciardi M., 25, 54 Guido M., 58 Gupta D., 75 Gupta R., 44, 78, 79 Gupta S., 29, 57 Gurel R., 46 Gurevich A., 53, 62 Gurevich T., 46 Gusmaroli G., 58, 70 Guzzetti S., 51, 55 H Ha C., 72 Habela P., 32, 61 Habibi S.A.H., 32, 60, 61 Hadinia A., 25, 26, 55 Haga R., 56 Hakkou E., 62 Hall C., 29, 39, 57, 58 Hallett M., 28, 36, 42 Ham J.H., 64, 67 Hamann C., 50 Hambardzumyan H., 51, 67 Hamilton-Dutoit S.J., 49 Han S., 66 Hanoglu L., 65 Harutyunyan K., 46, 64, 66, 67 Hasegawa K., 51, 71 Hasegawa S., 45 Hasegawa Y., 63 Hashimoto K., 62 Hattori N., 18, 29, 35, 56 Hatz F., 41, 71, 72 Hauser R., 32, 59 Hauser R.A., 56 Hayakawa H., 80 Hazama T., 58 Heckman M., 46 Hedges T., 67 Heida T., 65 Heinsen H., 34, 66 Hellberg C., 34, 67 Helmich R., 34 Helvaci Yilmaz N., 65 Hemo B., 46 Heo J., 51, 62 Hepp D., 35, 62 Herd C., 53 Herold-Nadig M., 54 Hersch S.M., 38 Hicks A.A., 79 Hidaka S., 26, 50, 55 Higuchi M., 46, 65 Hildebrand D., 25, 54 Hirata K., 62 Hirata Y., 80 Hirayama M., 45 Hirsch M., 30 Hirschbichler S.T., 63 Ho P., 72 Höglinger G., 21, 33 Hong J.Y., 64, 67 Hopp M., 35, 59 Hori H., 45, 74 Hori M., 25, 53 Horia N., 47, 49 Horiuchi E., 51, 71 Horowski R., 18, 32, 57, 60 Hosamani R., 78 Hosomi K., 62 Houvenaghel J., 22, 35, 52, 59 Hovhannes M., 46 Huh Y.E., 50 Hutz M., 29, 56 Hwang M., 20, 50, 64 I Iacopini M., 26, 55 Iakovleva I., 79 Iannello G., 74 Ibarretxe-Bilbao N., 55, 70 Ibodullaev Z., 48, 49, 64, 66, 75 Ibodullayev Z., 64 Iijima M., 47, 65 Ikeuchi T., 64 Ilic T., 27, 57 Ilyechova E., 75 Imaizumi Y., 73 Ince Gunal D., 66 Ingrassia A., 35, 62, 63 Inniss R., 39, 46, 47, 48, 71 Iranzo A., 19, 28 Irwin D., 21 Isaacson S., 27, 57, 60 Isaias I., 25, 34 Ishanhodjaeva G., 52 Islam T., 79 Ismoilov R., 67 Ivanova E., 30, 58 Ives N., 46 Iwaki H., 39, 61, 71 Iwasaki Y., 63 Iyer M., 73 Izyumov D., 55, 64 Izyumova G., 55, 64 J Jaakkola E., 71 Jabeen S.A., 60, 61, 62 Jaffe L., 55 Jaiswal S.K., 65 Jakobsson J., 56 Jalili Khoshnood R., 61 JALPAC Study Group, Jalundhwala Y.J., 30, 58 Jamrozik Z., 46, 66 Janik P., 46, 66 Jankovic J., 36, 37, 43 Janszky J., 22, 32, 52, 57, 61 Janzen A., 32, 60 Jardim L.B., 41, 73 Jaskólski A., 65 Jayakumar R., 75 Jeon B.S., 21, 63 XXI World Congress on Parkinson’s Disease and Related Disorders K Kaasinen V., 71 Kadi D., 50 Kadowaki T., 62 Kaelin-Lang A., 41, 44, 72, 76 Kaga K., 62 Kageyama Y., 62 Kagita V.P.V., 60, 61, 62 Kalampokini S., 51 Kale R.K., 75 Kalidindi R.R., 57 Kaminski D., 53, 62 Kandada R.M., 60 Kandadai D.R.M., 61 Kandadai R.M., 62 Kandukuri P.L., 30, 58 Kang K., 71 Kang B., 44, 79 Kang H.J., 66 Kang K., 53 Kang S., 49 Kang S.Y., 53, 67 Kanikannan M.A., 60, 61, 62 Kannan E., 57 Kapitsa I., 30, 58 Karaban I., 46 Karabanov A., 72 Karakhonova S., 52 Karasevich N., 46 Karbowniczek A., 48, 53, 54 Karbozova K., 45 Karpenko M., 45, 75 Karthikbabu S., 54 Kashyap N., 26, 50, 55 Kaufmann H., 31, 63 Kaut O., 35, 74 Kawashima N., 51 Kershner I., 72 Keshavarao S., 73, 75 Keshvarao S., 73 Kessel B., 48 Khachatryan E., 64 Khachaturyan S., 46, 64, 66, 67 Khalimova K., 45, 49, 54, 70 Khanna R.K., 76, 77 Khanna S., 29, 57 Khanna V.K., 44, 78, 79 Khanova M., 47, 53, 54, 76 Khasanova K., 51 Khatoonabadi S.A., 61 Katzenschlager R., 96 Khizanishvili N., 65 Khoddami M., 32, 60 Kiessling M., 34, 66 Kievit A.J., 41, 73 Kilner J., 22, 51, 52 Kim C., 47 Kim D., 20, 50 Kim H., 49, 51, 62 Kim H.J., 66 Kim H.-J., 19 Kim H.Y., 66 Kim I., 73 Kim J., 62, 74 Kim J.S., 48, 69 Kim K., 62, 74 Kim M., 62, 74 Kim M.S., 62 Kim S.J., 67 Kim S.Y., 74 Kim Y., 63 Kim Y.J., 62, 74 Kim Y.S., 50 Kin J.W., 49 Kinoshita M., 58 Kishima H., 62 Kisiel-Sajewicz K., 65 Kissani N., 64 Kitagawa K., 47, 65 Kitamura S., 58 Kjellander S., 58 Klamroth-Marganska V., 54 Kleiner A., 25, 54 Kleinfelder A.D., 67 Klingelhoefer L., 46 Kloda M., 50 Knudsen K., 49 Kobayashi Y., 51 Kok F., 69 Kokunai Y., 58 Komoly S., 57 Kon T., 56 Konaka K., 67, 76 Konitsiotis S., 65, 70 Konno T., 68, 68 Koprivnik P., 64 Korczyn A., 43 Korlipara P., 22, 52 Kostic V., 46 Kostic V.S., 40 Kotov S., 71 Kovacs G.G., 63 Kovács M., 22, 32, 52, 57, 61 Kovács N., 22, 32, 52, 57, 61, 66 Kovendan K., 45 Kozhemiako N., 46 Koziorowski D., 32, 46, 50, 61 Krack P., 62 Krahé C., 39, 68 Kramberger Gregoric M., 46 Kreitzman D., 27, 57 Krishna G., 78 Krishnan P., 73, 75 Krismer F., 63 Kros M., 74 Krygowska-Wajs A., 60 Krystkowiak P., 53, 60 Kryzhanovskyi S., 46 Kudrevatykh A., 45, 50 Kulikowski K., 60 Kulinski R., 39, 70 Kulisevsky J., 21, 24, 42, 96 Kulshreshtha A., 44, 76 Kulsum M.U., 56 Kumar D.A., 61 Kumar H., 56 Kumar N., 76, 77 Kumar P., 62, 75 Kumon A., 51 Kuranbaeva S., 56 Kuratomi A., 45 Kurbanov O., 48, 64, 66, 75 Kurisaki R., 45, 65 Kurnik M., 78 Kusmierska K., 46 Kuwabara S., 62 Kuzņecovs V., 65 Kvirkvelia N., 65 Kwon K.Y., 63 L L’Episcopo F., 78 La Ferla R., 58 Laabbar W., 79 Lacerenza M., 20, 49 Lacorte E., 47 Lakkappa N., 76 Lakshman Kumar B., 75 Landi A., 60 Landqvist Waldö M., 63 Landwehrmeyer G.B., 21 Lange M., 32, 60 Lanni D., 26, 55 Lanzillotta A., 44, 76 Larsen J.P., 29, 56 Larsson J., 58 Lau H., 74 Lauckaite K., 49 Laudisio A., 20, 22, 48, 51 Le Jeune F., 35, 59 Lecca D., 35, 62 Lee C.S., 73 Lee D., 66 Lee G., 54 Lee H., 71 Lee H.-W., 53 Lee J., 63, 64, 71, 74 Lee P.H., 53, 64, 67, 72 Lee S.H., 48 Lee W., 73 Leenders K.L., 41, 73 Lees A., 59 Lefranc M., 53, 60 Lefter R., 77 Lefteri K., 26, 56 Leite C., 69 Lemstra A., 35, 62 Lena F., 26, 55 Lenka A., 64, 71 Levandis G., 41, 74 NAME INDEX Jeong J.S., 62 Jeziorko S., 60 Jhunjhunwala K.R., 71 Jhunjhunwala K., 64 Jiddane M., 62, 66 Jimenez-Botello L.C., 59 Jin J.H., 66 Johnson A., 52 Johnson J., 49 Jorge De Sarachaga A., 48, 51 Joutsa J., 71 Joy J., 26, 56 Juraev M., 45, 49, 70 85 XXI World Congress on Parkinson’s Disease and Related Disorders NAME INDEX Leventhal L., 39, 57 Levin O., 47, 50 LeWitt P.A., 23 Li H.H., 39, 70 Li Y., 70 Liberski P.P., 63 Liguori C., 32, 59 Lim J.W., 74 Lim K., 72 Linden D., 54 Liu A., 39, 70 Liu F., 26, 56 Liu J., 34, 66 Lo Monaco M.R., 20, 22, 48, 51 Lobatz M., 29, 57 Locatelli P., 65 Loeschmann P.-A., 57 Lolekha P., 26, 50, 55 Lomax M., 35, 59 London E., 69 Longhena F., 79 Lopes N., 59 Lopez-Garcia A., 49 López-Muñiz A., 65, 70 Lopiano L., 31, 60, 74 Lotfinia M., 48, 76 Louis E.D., 34, 36, 43 Loureiro A.I., 78 Lubrani S., 26, 55 Lucas-Jimenez O., 55, 70 Luft F., 65 Luley M., 51 Lyashenko E., 47 Lye W., 47 Lyros E., 51 M Ma H., 53 Ma Y., 39, 71 Macedo D., 69 Macerollo A., 22, 52 Macklin E., 62 Macron J.M., 60 Madjidova Y., 64, 70 Maeda T., 51 Mahadevappa M., 39, 69 Mahalaxmi I., 74 Mahran L., 76 86 Mainardi L., 54 Majdinasab F., 32, 60, 61 Makkos A., 22, 32, 52, 57, 61 Maksudova K., 53 Malaguti M., 22, 53 Malaguti M.C., 20, 45 Mamadaliyev A., 64 Mancini F., 20, 22, 49, 51, 55, 58 Mandat T., 32, 50, 61 Mandemakers W., 41, 73, 74 Manfredi L., 20, 49, 51 Mangalore S., 64 Manvelyan H., 51, 64, 66, 67 Marabini L., 39, 77 Marano P., 58 Maras A., 54 Marchesi E., 22, 45, 50 Marchetti B., 78 Mariani C., 47 Mariani C.B., 52 Marino F., 73 Marraccini P., 27, 45 Marshall T., 30, 58 Martin A., 39, 48, 71 Martín Plasencia P., 52 Martinez-Martin P., 32, 35, 39, 41, 43, 48, 59, 71 Martino D., 48 Martinuzzi A., 60 Maruo T., 62 Marusiak J., 65 Masilamoni G., 39, 57 Masius R., 74 Massaia I.F.D.S., 63 Massimetti M.C., 52 Massucco D., 48 Matmurodov R., 45, 49, 54, 70, 76 Matsuno H., 47 Mauro A., 20, 45 Maurus A., 35, 59 Mazzotta S., 26, 55 Mcginley J., 50 Mckeown M.J., 39, 70 McRiner A., 39, 57 Mdivani M., 65 Meco G., 47, 52, 53, 58 Medakkar S., 78 Meglic B., 46 Mehrkens J., 62 Meira Santos Lima M., 77 Melamed E. †, 19, 25 Melhaoui A., 62 Melloni E., 75 Melzi V., 73 Mendes A., 52, 62 Mendez-Rial B., 50, 54 Menendez-Gonzalez M., 65, 70, 71 Mengesha K., 49 Menig A., 54 Merello M., 41, 72 Merle P., 60 Merola A., 35, 39 Meucci N., 52 Meyer A., 22, 25, 26, 41, 51, 55, 71, 72 Meyyazhagan A., 73, 74, 75 Michałowska M., 45 Michel A., 36, 77 Mihara M., 67, 76 Milanowski L., 66 Miliukhina I., 45, 50 Mills R., 27, 57 Milyukhina I., 75 Min J.Y., 51 Minato T., 45 Minella S., 55 Minneboo M., 41, 73, 74 Mirabella G., 26, 32, 55, 61 Mirdedaev S., 48, 56 Mirzaeva K., 65 Mishima T., 46, 65 Miska Thölken K.F., 67 Missale C., 79 Mitani Y., 58 Mizuno Y., 73 Moccia M., 27, 52 Mochizuki H., 62, 67, 73, 76, 80 Modi N., 29, 57 Modugno N., 26, 32, 55, 58, 60, 61 Moeller J., 41, 72 Moganty R.R., 69 Mohd Noor S., 76 Mohd Y., 73, 75 Mohire S., 57 Moll M.A.K.D., 66 Möller J.C., 54 Mollinedo-Cardalda I., 50, 53 Monchi O. Mondal B., 56 Mondani M., 60 Monfrini E., 73 Mongiovetti M., 70 Monti C., 74 Monti V., 34, 66 Montpellier D., 60 Monzio Compagnoni G., 63 Moon S.W., 70 Moors T., 63, 79 Morari M., 75 Moreira I., 52 Morelli M., 46, 74 Moreno-Reig A., 49 Moret V., 62 Morgante F., 22, 24, 27, 28, 51, 52, 58, 67 Morita M., 64 Moro A., 69, 70 Moro E., 24, 38, 62 Morris H., 54 Morris S., 62 Moscovich M., 69, 70 Moskała M., 60 Moti E., 47, 49 Mousa G., 64 Mugge W., 65 Muinjonov B., 34, 45, 46, 47, 63, 64, 74 Mulas G., 35, 62 Mulholland N., 39, 71 Müller E., 58 Mulukutala S., 57 Munhoz R., 69, 70 Muñoz-Soto R.B., 59 Muralidhara M., 78 Muratov F., 55 Murayama S., 64, 73 Murer T., 47 Murgia M., 25, 54 Murthy V., 57 Murugan K., 45, 75 Musaeva Y., 56 Musayeva Y., 45, 46 XXI World Congress on Parkinson’s Disease and Related Disorders N Nadkarni N., 47 Naduthota R., 45 Nagai M., 39, 61, 71, 73 Naghavi-Behzad M., 46 Nagy M., 32, 61, 66 Nakahara K., 45 Nakajima M., 77 Nakamura S., 51, 71 Nakashima K., 63, 64 Nakashita S., 63 Naskar D., 56 Nazaryan A., 66, 67 Ndiaye M., 20, 45, 47 Ndiaye M.M., 20, 45, 47 Negrotti A., 22, 45, 50 Nehru B., 78 Nerino R., 20, 45 Neshige R., 65 Netravathi M., 39, 69, 71 Neumann S., 54 Ng K.M., 39, 70 Nicolas J., 36, 77 Nicoletti G., 74 Niewiadomska G., 48, 53, 54, 77 Niewiadomski W., 48, 53, 54, 77 Nihira T., 73 Nilsson L., 79 Nilsson C., 63 Nilsson K., 63 Nirenberg M., 53, 67 Nishida Y., 45 Nishijima H., 56 Nishikawa N., 39, 61, 71, 73 Nobili L., 27, 45 Nodel M., 47 Nomoto K., 45 Nomoto M., 39, 61, 71 Norazit A., 76 Nowak K., 22, 25, 26, 41, 51, 53, 55, 72 Ntritsos G., 65 Ntzani E., 65 Nunomura J., 56 Nurmetov N., 48, 49, 64, 66, 75 Nurmetov O., 49 Nyholm D., 58 O Obata F., 73 Obata T., 77 Obeso J., 97 Obukhov Y., 72 Ocepek L., 46 Ocha R.A.J., 63 Odin P., 29, 31, 48 Oechsner M., 54 Ogino M., 73 Ogunniyi A., 20, 50 Ogura J., 58 Ogura H., 46 Ohno K., 45 Ohta E., 73 Ohyama M., 73 Oiwa K., 63 Ojeda N., 55, 70 Oka H., 47 Okada Y., 73 Okamoto A., 45 Okano H., 73 Okiljonova N., 70 Okun M., 65 Olanow C.W., 97 Olgiati S., 34, 41, 66, 73 Oliveira C., 59 Olofsson A., 79 Onder G., 20, 22, 48, 51 Ondo W., 57 Onodera O., 64 Onofrj M., 24, 43, 48, 63 Onuk K., 57 Onuma S., 71 Onuma H., 51 Orban G., 44, 76 Orrico D., 20, 45 Osawa M., 47 Oshino S., 62 Otomune H., 76 Owolabi M., 20, 50 Ozmenoglu M., 66 P Pacchetti C., 41, 58, 60, 74 Paciotti S., 63, 79 Padma M.V., 69 Padmakumar C.P., 52 Padmakumar G., 52 Padoani G., 75 Padurariu M., 77 Pagni C., 71 Pahwa R., 57 Pál E., 32, 61 Pal P., 42 Pal P.K., 39, 45, 64, 69, 71 Pal S., 48 Palasz E., 48, 53, 54, 77 Pandey P., 76 Panea C., 47, 49 Pant A.V., 79 Pant A.B., 44., 78 Panteghini C., 34, 66 Papa S., 39, 57, 96 Papi C., 47, 52 Pappa M., 65 Parent M., 77 Pariaszewska K., 54 Parisi F., 20, 45 Park J.-S., 53 Park K.H., 47 Park M., 49 Park M.H., 51 Parkins L., 48 Parnetti L., 46, 63, 79 Parolini M., 27, 45 Parrella E., 44, 76 Parry M., 39, 48, 71 Pascale E., 47 Pasco P.M., 59 Pasha S.A., 64 Pastorello P., 70 Pau M., 25, 54 Pavino V., 52 Pellecchia M.T., 27, 52 Pellegrini M., 20, 45 Pellegrino E., 20, 49 Peña J., 55, 70 Perera T., 50 Peretz C., 46 Perkins L., 39, 46, 47, 71 Permert J., 58 Perrini P., 65 Pertile R., 20, 45 Petrovic M., 46 Petrucci S., 27, 52 Petryszyn S., 77 Pettorino M., 20, 49 Pezzoli G., 26, 36, 39, 41, 52, 72, 73, 77, 79 Pfeiffer R., 36, 40 Photopoulou A., 39, 68 Pianu D., 20, 45 Picard A., 79 Piccolo I., 27, 45 Pichai Fenn J., 73 Pichler I., 79 Pierantozzi M., 32, 59 Pietraszko W., 60 Piffer S., 20, 45 Pili R., 25, 54 Pillai E., 35, 62 Pilleri M., 58, 60 Piplani P., 44, 76, 77 Piqueras-Flores J., 49 Piri R., 46 Pirtošek Z., 39, 46, 71, 96 Pisciotta M.S., 20, 22, 48, 51 Pizzi M., 44, 76, 79 Placidi F., 32, 59 Plate A., 50 Plebani M., 79 Poddubskaya A., 30, 57 Poewe W., 30, 57, 58, 97 Polak J., 60 Polat B., 65 Politis M., 39, 71 Polosan M., 62 Poluektov M., 47 Polverino A., 20, 45 Pomati S., 47 Ponte Junior J.R.T., 63 Porrini V., 44, 76 Poryazova R., 47 Potashkin J., 22, 52 Potasz-Kulikowska K., 60 Potrzebowska I., 50 Pozzi B., 52 Pradotto L.G., 20, 45 Prakash K.M., 47, 74 Pramstaller P.P., 79 NAME INDEX Mutti A., 45 Muzerengi S., 46, 53 87 XXI World Congress on Parkinson’s Disease and Related Disorders NAME INDEX Prashanth L.K., 54 Preda F., 60 Priori A., 26, 38, 47, 60 Proserpio P., 27, 45 Przybyszewski A., 32, 61 Puchkova L., 75 Puligopu A.K., 60 Pulligopu A.K., 62 Puppi Munhoz R., 64 Purcaro C., 47 Puschmann A., 34, 35, 67, 68 Q Quadri M., 34, 41, 66, 73 Quartarone A., 62, 67 Quatrale R., 58 Quattrone A., 46, 74 R Rademakers R., 72 Radhakrishnan M., 75 Rady M., 76 Rajnar R., 46 Rajput S. Raju T.R., 78 Rakhimbaeva G., 51, 52, 64, 65, 71 Rakhimbayeva G., 45, 46 Rakowicz M., 39, 69 Ramalingam J., 74, 75 Rampelli S., 26, 55 Rascol O., 35, 57, 59, 96 Raskin S., 69 Ravagnani M., 70 Ravisankar P., 79 Ray Chaudhuri K., 19, 23, 39, 71 Re V., 65 Reale C., 34, 66 Reali E., 52 Rees M., 52 Regragui W., 62, 66 Reichmann H., 35, 37, 46 Rektor I., 43 Rektorova I., 24, 33 Revicki D., 30, 58 Revy D., 77 Rey N.L., 19 Reyes J.P., 66 88 Reynolds G.O., 55 Rezzani R., 79 Ribacoba Montero R., 71 Ribas G., 67 Riboldazzi G., 32, 54, 58, 73 Riccardi S., 45 Ricciardi D., 22, 51 Ricciardi L., 22, 27, 39, 51, 52, 68 Rick C., 46, 53 Rieck M., 29, 56 Riedel G., 77 Rieder C.R., 41., 73 Riederer P., 18, 19, 27, 37, 40, 53, 57 Riener R., 54 Rigoldi C., 54 Rimoldi V., 36, 79 Rispoli V., 34, 66 Rizos A., 30, 39, 46, 47, 48, 49, 59, 71 Rizzo V., 67 Robelet S., 77 Roberta F., 56 Robieson W., 39, 58 Rocha J., 59 Rodnitzky R., 40 Rodriguez R., 29, 39, 57, 58 Rodriguez-Agudelo Y., 48 Rodriguez-Fuentes G., 50, 53 Rodriguez-Oroz M.C., 29, 37 Rodriguez-Violante M., 48, 51 Roesch A.D., 22, 26, 51, 53, 55 Roh H., 66 Rola R., 39, 69 Romeo T., 52 Romito L., 34, 35, 39, 60, 66 Romito L.M., 27, 48 Roni R., 20, 45 Rood J.P., 41, 73 Rosa M., 60 Rosa S., 73 Rosani V., 46 Ross O., 18, 25, 72 Rossi S., 58 Roth J., 40 Roth V., 71 Rothenfußer-Korber E., 32, 60 Rothwell J., 22, 52, 67 Rouigari M., 72, 75, 76 Rouiller E., 62 Roussel M., 60 Rovaris G., 36, 79 Rozemuller A., 35, 62 Rubens R., 29, 57 Rubino A., 47, 52, 53 Rucker J., 70 Rumpel H., 39, 70 Russo A., 41, 72 Ryo M., 73 Ryu H., 62, 74 S Sacilotto G., 52, 73 Saddi M.V., 58 Sadikov R., 56, 67 Saiki S., 35 Sail K., 30, 58 Saini J., 64, 71 Saitoh Y., 62 Sakakibara R., 62 Sakhya S., 69 Salani S., 63 Salazar G., 60 Sale P., 25, 54 Salehi S., 61 Samuel M., 24, 33 Sanchez-Martinez A., 56 Sankova T., 75 Santhosh D.V., 39, 69 Santiago R., 77 Santiago J., 22, 52 Santilli M., 32, 61 Santillo A., 63 Santos A., 59 Santos G., 69 Sanvito W.L., 63 Sarasso S., 41, 72 Sardina M., 58, 75 Sari H.T.J., 29, 56 Sarubbo S., 60 Saruwatari M., 51 Sasaki T., 80 Sasanelli F., 34, 66 Sasikala K., 75 Sauerbier A., 30, 39, 46, 47, 48, 59, 71 Sauleau P., 22, 52 Saute J.A., 41, 73 Savio K., 70 Sawada J., 58 Scannapieco S., 74 Scavasine V., 67 Scelzo E., 60, 62 Schachter L., 77 Schapira A., 37 Scheller D., 36, 77 Scherzer C., 62 Schieferdecker M.E., 69 Schilling T., 56 Schlaier J., 32, 60 Schmitt I., 35, 74 Schmitz C., 34, 66 Schmulewitz N., 39 58 Schneider S.A., 21 Schouten A., 65 Schuller B., 53 Schumacher-Schuh A., 29, 56 Schuurman P.R., 61 Schwarzschild M., 62 Schwarzschild M.A., 26 Schweinfurther R., 54 Schwienbacher C., 79 Scola R.H., 67 Sebastianutto I., 56 Seck L.B., 20, 45 Seia M., 73 Seigneuret E., 62 Seijo M., 54 Sen S., 56 Sensi M., 34, 58, 60, 66 Seo J., 73 Seppi K., 63 Serafin A., 79 Serapide M.F., 78 Serbanoiu I., 47, 49 Seresini A., 73 Sergeev T., 50 Serrano Rodríguez J.M., 52 Severiano M.I., 69 Shabalov V., 30, 57 Shaffali S., 77 Shafi Ahammed Khan M., 73, 75 Shanawaz D., 73, 75 Shanidze L., 65 XXI World Congress on Parkinson’s Disease and Related Disorders Soliveri P., 27, 48 Son A., 53, 62, 70 Song W., 76 Song H., 53, 67 Song S.K., 67 Song W., 44 Sophia R., 48 Soriano-Ursua M.A., 59 Sousa F., 78 Sow A.D., 20, 45, 47 Spano P., 79 Spano P.F., 44, 76 Spiegel J., 51 Spiga S., 35, 62 Spillantini M.G., 79 Srinivasan S., 75 Srivastava A.K., 69 Srivastava M.V.P., 69 Srivastava P., 44, 78, 79 Staedler C., 41, 72 Stamelou M., 24, 28, 33, 38, 63 Standaert D., 29, 57 Stanzione P., 52 Stashuk G., 71 Steczkowska M., 77 Stefani A., 32, 52, 58, 59 Stefanova E., 46 Stein D., 39, 58 Stepniak I., 39, 69 Sticklor K., 62 Stocchi F., 23, 25, 31, 54, 96, 97 Stoessl A.J., 24, 42 Stojkovic T., 46 Stolarczyk A., 61 Stolarczyk M., 61 Stone B., 53 Storch A., 29 Strafella A., 24, 33 Straniero L., 36, 41, 72, 79 Strasz A., 48, 53, 54 Straumann D., 49 Strongosky A., 46, 68, 72 Stuhlinger L., 50 Stuijt C., 27, 56 Sturzenegger R., 41, 72 Subramaniam M., 74 Subramanian L., 54 Subramanium M., 73 Sulek A., 39, 69 Sumi-Akamaru H., 76 Sung Y., 47 Sunny A.S., 71 Sunwoo M.K., 53, 64 Sushkova O., 72 Suzuki C., 56 Suzuki K., 62 Swarup V., 69 Świercz D., 65 Syed N., 54 Szatanowski T., 45 Szejko N., 66 Szlufik S., 32, 46, 50, 61 Szumilas M., 32, 61 T Tacik P., 46 Taconeli C., 69 Tada S., 39, 71 Tadjenov M., 56 Tajiri Y., 63 Takahashi A., 63 Takahashi K., 73 Takamoto H., 25, 53 Takashima A., 73 Takata K., 58 Takeda T., 65 Takigawa H., 64 Taliyan R., 77 Tambasco N., 46 Tamburini T., 48 Tamma F., 58, 60 Tan E., 47, 72 Tan E.K., 18, 39, 43, 44, 70, 74 Tan J., 50 Tan S.N., 39, 70 Tanaka K., 61 Tang X., 39, 57 Tasegian A., 79 Tedeschi G., 41, 72 Tedja A.K., 79 Teive H., 64, 67, 69, 70 Teive H.A.G., 69 Terranova C., 67 Tesei S., 52 Tessitore A., 24, 44, 58, 72 Testa N., 78 Thaggikuppe Krishnamurthy P., 76 Thangamani L., 74, 75 The Hydrogen Water Parkinson Study Group, 56 Thevathasan W., 50 Thiago Z., 77 Thomas A., 48 Thor P., 78 Tibar H., 66 Tieu K., 80 Tilderkvist K., 63 Tinazzi M., 28, 67 Tir M., 53, 60 Tirolo C., 78 Tognoni G., 71 Tokuda T., 64 Tolibov D., 52, 71 Tolibova N., 47, 53, 54, 76 Tomaz R., 39, 71 Tomiyama M., 56 Tomse P., 39, 71 Tomskiy A., 30, 57 Toshev J., 48, 49 Tost J., 35, 74 Toure K., 20, 45 Toyoda C., 47 Trendafilov V., 41, 72 Trezzi I., 73 Trigun S.K., 78 Trivedi D., 39, 46, 47, 48, 71 Trojanovic N., 39, 71 Trost M., 39, 46, 71 Truong D., 36, 37, 67 Tseretopoulou X., 65 Tsuboi Y., 46, 65 Tsugawa J., 65 Tsuji H., 45 Tsujii T., 39, 71 Turgunkhujaev O., 47, 53, 54, 76 Turner D., 54 Tursunov D., 78 Tysnes O.B., 29, 56 Tzamir J., 46 Tzoulaki I., 65 U Uchihara T., 65 Uchino A., 73 NAME INDEX Sharan P., 44, 72, 74 Sharifi S., 65 Sharma D., 74 Sharma N., 78 Sharma S., 75, 77 Sharma V., 55, 76, Shenolikar S., 74 Shibata-Yamaguchi C., 62 Shill H., 32, 59 Shimizu T., 62 Shimohata T., 64 Shimokawa T., 62 Shin C.M., 63 Shin J., 73 Shinoda T., 51 Shinzawa K., 76 Shiong Shu L., 59 Shubham S., 56 Shukla G., 69 Shukla R., 44., 78 Shukla R.K., 78, 79 Sikorska B., 63 Silva M., 67 Silva M.A.G.T., 63 Simancas-Ruiz J.E., 51 Simanjaya S., 79 Singh A., 39, 57 Singh I., 69 Singh L., 76 Singh R., 44, 78 Siri C., 52, 73 Sitepu E.C., 79 Siwek G., 60 Skaper S., 79 Skeie G.O., 29, 56 Skripkina N., 50 Skupinska M., 48, 77 Slevin J., 29, 57 Slubowska E., 32, 61 Smeltere L., 65 Smelters R., 65 Sneha B.S., 54 Soares-da-Silva P., 59, 78 Sobanska A., 39, 69 Soh Y.H., 53 Sohn Y., 64 Sohn Y.H., 53, 67, 72 Sokhibnazarov N., 55 Soldà G., 36, 41, 72, 79 89 XXI World Congress on Parkinson’s Disease and Related Disorders NAME INDEX Uchiyama S., 65 Uchiyama T., 62 Uekawa K., 45 Ueno T., 56 Uesato S., 80 Uitti R., 35, 72 Ukraintseva J., 47 Umehara T., 47 Umemoto G., 46 Unger M., 51 Upadhyaya K., 74 Usta N., 66 Uzan-Gueta R., 77 V Vaamonde-Gamo J., 49 Vailati S., 75 Valdman E., 30, 58 Valente E.M., 19, 27, 52 Valente G.O.R., 53 Valente M., 47, 52, 53 Valko P., 47, 49 Vallauri D., 39, 77 Valldeoriola F., 31 Van De Berg W., 35, 62, 63 Van De Berg W.D., 79 van de Berg W.D.J., 29, 44 Van Den Munckhof P., 61 Van Der Westhuizen F.H., 74 Van Gerpen J., 72 Van Gils S., 61 van Laar T., 21, 27, 31, 56 Van Poppelen D., 60 Van Rootselaar A., 65 Van Westen D., 63 Vanacore N., 20, 45, 47 Vega Álvarez J., 65, 70 Vegezzi G., 44, 76 Vellingiri B., 73, 74, 75 90 Verhagen R., 61 Verheijen F.W., 41, 73 Vérin M., 22, 35, 52, 59 Verma A., 67 Vestberg S., 63 Vetrano D., 20, 48 Vetrano D.L., 22, 51 Vidyadhara D.J., 78 Vila M.H., 50, 54 Vila-Chã N., 52 Vilela R., 69 Vincent S., 45 Vingerhoets F., 34, 75 Visco-Comandini F., 22, 51 Vital M., 77 Vitale C., 40 Vivian G., 39, 71 Vivian J., 78 Volkmann J., 36, 43 Volonté M.A., 61 Volterrani D., 65, 71 Voronina T., 30, 58 Vorovenci R.J., 53 Voskanyan A., 46, 64, 66 Vucolova L., 20, 25, 49, 53 Vuletic V., 34, 67 W Wada-Isoe K., 63 Waldvogel D., 47 Wang J., 39, 41, 70, 73 Wang L., 34, 66 Watanabe Y., 62, 76 Weber K., 49 Weintraub D., 56 Weis L., 52, 63 Weiss L., 53 Wenning G., 63 Wenning G.K., 19, 33, 38 Werth E., 47, 49 Whitworth A.J., 56 Wictor L., 35, 68 Wictorin K., 35, 68 Wider C., 74, 75 Widner H., 35, 58, 68 Wiklund I., 30, 58 William H., 57 Williams H., 27, 57 Willows T., 58 Withanage A., 52 Witt S., 35, 74 Woldehana A.M., 51 Wolters E.Ch., 18, 19, 23 Wong D., 76 Woodward J., 67 Woolley R., 46 Wszolek Z.K., 18, 25, 40, 46, 68, 72 Wüllner U., 35, 74 Y Yabe H., 61 Yabe Y., 39, 71 Yadav R., 39, 45, 64, 69 Yadav R.S., 65 Yahyaoui M., 66 Yakhno N., 47 Yamamoto M., 71 Yamanishi T., 62, 71 Yanamoto S., 46, 65 Yang C., 80 Yang Y., 63 Yaria J., 20, 50 Yarreiphang H., 78 Yasuda T., 80 Yasui K., 63 Yegin A., 30, 57, 58 Yeoh C.S., 39, 70 Yokoe M., 62 Yong M., 47 Yong M.H., 74 Yoon U., 71 Yoon J.E., 69 Yoon W.T., 67 Yoritaka A., 56 Yoshida M., 63 Yoshikawa H., 58 Yoshimine T., 62 You S., 62, 74 Youdim M.B.H., 18, 37, 38 Youn J., 20, 50, 69 Yu P., 80 Yun E.J., 63 Yun H.J., 64 Yunusov F., 51 Z Zali A., 61 Zaltieri M., 79 Zangaglia R., 41, 74 Zanigni S., 79 Zanon A., 79 Zecchinelli A.L., 52 Zeigelboim B.S., 69 Zhang J., 41, 73 Zhang Y., 39, 70 Zibetti M., 58 Zikou A., 70 Zimprich A., 18 Zini M., 52, 73 Zouitina Y., 53, 60 Zuccalà G., 20, 22, 48, 51 Zuneda Serafini S., 67 Zupancic Kriznar N., 46 Zutter D., 54 Zylinski M., 48, 54, 77 XXI World Congress on Parkinson’s Disease and Related Disorders CONGRESS VENUE MiCo – Milano Congressi Congress Centre (Fiera Milano) Via Gattamelata (Entrance Gate 14) - MiCo North Wing 20149 Milano - Italy Tel. +39 02 4997 6275 Fax +39 02 4801 0265 Website: www.micomilano.it ORGANIZING SECRETARIAT GENERAL INFORMATION GENERAL INFORMATION OIC s.r.l. Viale G. Matteotti 7 50121 Florence - Italy Tel. +39 055 50351 Fax +39 055 5001912 infoiaprd2015@oic.it www.oic.it/iaprd2015 REGISTRATION DESK The Registration Desk will be situated on level +1 of the MiCo Congress Centre North Wing and will be open for registration and information according to the following time schedule: Sunday, December 6 Monday, December 7 Tuesday, December 8 Wednesday, December 9 8.00-21.00 8.00-19.00 8.00-19.00 8.00-15.30 Please collect the conference kit at the Registration Desk and wear your personal name badge during the scientific sessions and social activities. 91 XXI World Congress on Parkinson’s Disease and Related Disorders GENERAL INFORMATION REGISTRATION FEES – ON SITE Fees are in Euro and include VAT REGISTRATION FEES Full Participants Students/Trainees/ Post-Docs/Fellows and Residents* Allied health professionals* Emerging Countries** Exhibitors Congress Dinner ON-SITE € 750,00 € 400,00 € 400,00 € 400,00 € 400,00 Educational Sessions*** € 25,00 € 95,00 * In order to benefit from the reduced fee, the registration form must be accompanied by a letter from the head of the department confirming this status and/or a valid student card. ** Emerging countries are defined according to the World Bank Country Classification of Low income and Lower-middle income economies. *** The fee includes the participation in all Educational Sessions indicated in the scientific program and the textbook “PD and Other Movement Disorders” for free. REGISTRATION FEES FOR ALL CONGRESS PARTICIPANTS INCLUDE: − Free access to the Welcome Reception − Participation in scientific sessions − Entrance to the exhibition area − Final program book and other printed material of the Congress − Certificate of Attendance − Access to CME certificate after the Congress − Lunches and refreshments according to the program − Free Associate Membership of IAPRD with free electronic subscription to its journal “Parkinsonism and Related Disorders” BADGES Participants are kindly requested to wear the name badge when entering the Congress venue and to access any offered services. Badge color coding is as follows: No color = Delegates Blue = Faculty Gold = IAPRD Executive Scientific Board Red = Exhibitors Yellow = Press 92 CERTIFICATE OF ATTENDANCE The certificate of attendance will be obtainable on site. XXI World Congress on Parkinson’s Disease and Related Disorders CLOAKROOM AND LUGGAGE DEPOSIT A cloakroom and luggage deposit located on level +1 will be available during the official Congress time schedule. MiCo Congress Centre and the organisers are not responsible for any items lost or left behind. EXHIBITION An exhibition of the latest pharmaceutical products, electromedical devices and scientific publications is located on level +1 of the MiCo North Wing. Opening hours will be corresponding to the congress activities as follows: Sunday, December 6 9.00-21.00 Monday, December 7 8.00-18.45 Tuesday, December 8 8.00-18.45 Wednesday, December 9 8.00-15.30 GENERAL INFORMATION REFRESHMENTS Coffee and tea, refreshments and lunch will be offered to all registered participants in the Exhibition Area at the times indicated in the timetable. Delegates will have the chance to visit the Poster Area as well as the Technical Exhibition on level +1 of the MiCo North Wing. FREE WI-FI Free wi-fi Internet connection is available in all meeting rooms and common spaces. LOST AND FOUND For lost and found items, please refer to the cloakroom on site. MOBILE PHONES The use of mobile phones is not allowed during all scientific sessions. Mobile phones must be switched off or muted. SMOKING POLICY Smoking is strictly prohibited during all meetings and sessions and in exhibition halls at all times. Your compliance is appreciated. 93 XXI World Congress on Parkinson’s Disease and Related Disorders SOCIAL EVENTS SOCIAL EVENTS OPENING CEREMONY Sunday, December 6 -hrs 18.30 Silver Hall – MiCo Congress Centre (Congress venue) WELCOME RECEPTION Sunday, December 6 - hrs 20.00 Exhibition Area – MiCo Congress Centre (Congress venue) CONGRESS DINNER Tuesday, December 8 – hrs 20.00 Gessi Milano Showroom – Via A. Manzoni 16/A - Milan The Congress Dinner of the XXI World Congress on Parkinson’s Disease and Related Disorders will be held in a very unique venue, set right in the core of the fashion and design district of Milan city centre which represents its true soul. Gessi brand is acknowledged worldwide for its fashionable designs in all types of living environments. With its creations, Gessi has created a new style of living: a “design to be experienced, to be worn and breathed”. On March 2013 Gessi opened the brand new Gessi Milano Showroom inside a historic building in the upscale fashion district. The area, a former movie theater, was radically reinterpreted creating an actual plunge into nature in a “secret garden”, unexpected, inspired by the Parco Trivulzio on which the Space stands. A special evening in a special location! Tickets for the Dinner at € 95,00 are available at the registration desk. 94 Oregon Convention Center September 20 – 23, 2016 ATTENDEES WILL INCLUDE Movement Disorder Specialists Neurologists & Neuroscientists Geriatricians & Family Physicians Nurses & Social Workers Physical, Occupational & Speech Therapists People with Parkinson’s disease Care partners & Family Representatives of industry The 4th World Parkinson Congress is a unique international event designed to bring together the full spectrum of people who live with Parkinson’s disease and those who serve the Parkinson community. We hope this cross-pollination helps in finding a cure as well as identifying the best treatment practices for people living with Parkinson’s. www.WPC2016.org The official language of the WPC 2016 is English. IMPORTANT DATES DECEMBER 7, 2015 Abstract Submission opens JANUARY 11, 2016 Registration and Housing open APRIL 25, 2016 Abstract Submission & Travel Grant Application deadline JULY 5, 2016 Early Registration deadline XXI World Congress on Parkinson’s Disease and Related Disorders SPONSORED SYMPOSIA MONDAY, 7 DECEMBER - 11.45-12.45 RED HALL 1 ZAMBON SYMPOSIUM SAFINAMIDE FOR THE MANAGEMENT OF MID- TO LATE-PD PATIENT: A CASE-BASED REVIEW 11.45 New treatment options for mid- to late-PD stage - the clinical development of safinamide F. Stocchi (Italy) 12.00 Beyond the dopaminergic pathway in mid- to late-PD stage - the mechanism of action of safinamide S. Papa (USA) 12.15 New approaches for managing motor complications O. Rascol (France) 12.30 Advances in the management of non-motor symptoms in PD P. Barone (Italy) MONDAY, 7 DECEMBER - 12.45-13.45 BLUE HALL ABBVIE SYMPOSIUM ADVANCED PARKINSON DISEASE: FROM SCIENCE TO CLINICAL APPLICATION Chairman: J. Kulisevsky (Spain) 96 12.45 Welcome and Introduction J. Kulisevsky (Spain) 12.50 Advanced PD: incidence, definition, and patient considerations Z. Pirtošek (Slovenia) 13.05 Optimizing treatment strategies: changing the mode of delivery R. Katzenschlager (Austria) 13.20 Translating scientific and clinical data into real world setting R. Katzenschlager (Austria) 13.35 Multidisciplinary care and aftercare: establishing best practices for patients and caregivers Z. Pirtošek (Slovenia) XXI World Congress on Parkinson’s Disease and Related Disorders SILVER HALL CYNAPSUS SYMPOSIUM Chairmen: C.W. Olanow (USA), F. Stocchi (Italy) 12.00 Motor complications - Phenomenology and mechanisms J. Obeso (Spain) 12.20 Current therapy for motor complications in PD W. Poewe (Austria) 12.40 Rescue therapies - A new direction in the treatment of OFF episodes C. Warren Olanow (USA) 13.00 KOL Panel Discussion J. Obeso (Spain), C.W. Olanow (USA), W. Poewe (Austria), F. Stocchi (Italy) SPONSORED SYMPOSIA TUESDAY, 8 DECEMBER - 12.00-13.30 97 XXI World Congress on Parkinson’s Disease and Related Disorders WHITE ROOM 2 WHITE ROOM 1 TO LEVEL +1 CONGRESS VENUE LAYOUT Level +2 SILVER HALL FROM LEVEL +1 98 XXI World Congress on Parkinson’s Disease and Related Disorders YELLOW HALL 1 Faculty Lounge SLIDE CENTRE RED HALL 1 BLUE HALL 1,2 RED HALL 2 TO LEVEL +2 FROM LEVEL 0 YELLOW HALL 3 FROM LEVEL +2 Buffet Lunch 5 4 3 Buffet Lunch 2 CONGRESS VENUE LAYOUT Level +1 6 9 REGISTRATION AREA 8 7 SELECTED TOPIC SESSIONS AREA 10 11 POSTER AREA ENTRANCE TO EXHIBITION 12 BAR REGISTRATION AREA HISTORY OF PD EXHIBITION 17/18 POSTER AREA 16 CLOAKROOM Buffet Lunch COMPANY NAME ABBVIE BRITANNIA PHARMACEUTICALS CANÈ MEDICAL TECHNOLOGY EVER NEURO PHARMA GONDOLA MEDICAL TECHNOLOGIES IAPRD 2017 DESK IAPRD SOCIETY DESK MEDTRONIC MERKUR DESK MERZ ST. JUDE MEDICAL WISEPRESS MEDICAL BOOKSHOP ZAMBON BOOTH CODE 10 9 11 6 12 4 5 17-18 3 2 7 8 16 99 Restoring Movement with Ease LJŶĂƉƐƵƐŝƐƉƌŽƵĚƚŽďĞĂƐƵƉƉŽƌƚĞƌŽĨƚŚĞ yy/tŽƌůĚŽŶŐƌĞƐƐŽŶWĂƌŬŝŶƐŽŶ͛Ɛ ŝƐĞĂƐĞĂŶĚDŽǀĞŵĞŶƚŝƐŽƌĚĞƌƐ͘ LJŶĂƉƐƵƐŝƐĂƐƉĞĐŝĂůƚLJƉŚĂƌŵĂĐĞƵƚŝĐĂůĐŽŵƉĂŶLJƚŚĂƚŝƐ ĨŽĐƵƐĞĚŽŶƚŚĞĐůŝŶŝĐĂůĂŶĚƌĞŐƵůĂƚŽƌLJĚĞǀĞůŽƉŵĞŶƚŽĨĂ ƐƵďůŝŶŐƵĂůĂƉŽŵŽƌƉŚŝŶĞĨŝůŵƐƚƌŝƉ;W>ͲϭϯϬϮϳϳͿ͘ LJŶĂƉƐƵƐΖĚƌƵŐĐĂŶĚŝĚĂƚĞ͕W>ͲϭϯϬϮϳϳ͕ŝƐĂƐƵďůŝŶŐƵĂů ĨŽƌŵŽĨĂƉŽŵŽƌƉŚŝŶĞƚŚĂƚŝƐĐƵƌƌĞŶƚůLJĞŶƌŽůůŝŶŐƉĂƚŝĞŶƚƐ ŝŶWŚĂƐĞ///ĐůŝŶŝĐĂůƐƚƵĚŝĞƐ;ĐůŝŶŝĐĂůƚƌŝĂůƐ͘ŐŽǀ͗ EdϬϮϰϲϵϬϵϬĂŶĚEdϬϮϱϰϮϲϵϲͿ͘ ƉŽŵŽƌƉŚŝŶĞ͕ǀŝĂŝŶũĞĐƚŝŽŶ͕ŝƐĐƵƌƌĞŶƚůLJƚŚĞŽŶůLJĂƉƉƌŽǀĞĚ ĚƌƵŐĂŶĚƌŽƵƚĞŽĨĂĚŵŝŶŝƐƚƌĂƚŝŽŶ;ŝŶƚŚĞhŶŝƚĞĚ^ƚĂƚĞƐ͕ ƵƌŽƉĞ͕:ĂƉĂŶĂŶĚŽƚŚĞƌĐŽƵŶƚƌŝĞƐͿĨŽƌƚŚĞĂĐƵƚĞ͕ ŝŶƚĞƌŵŝƚƚĞŶƚƚƌĞĂƚŵĞŶƚŽĨΗK&&ΗĞƉŝƐŽĚĞƐŝŶƉĂƚŝĞŶƚƐǁŝƚŚ WĂƌŬŝŶƐŽŶΖƐĚŝƐĞĂƐĞ͘ 549$5)/"4%"2$:/" XXXDZOBQTVTDB XXI World Congress on Parkinson’s Disease and Related Disorders PLATINUM SUPPORTER GOLD SUPPORTER SILVER SUPPORTERS ACKNOWLEDGEMENTS The XXI World Congress on Parkinson’s Disease and Related Disorders would like to acknowledge the support of the following companies: SUPPORTERS abcd 101 XXI World Congress on Parkinson’s Disease and Related Disorders COMPANY PROFILES Abbvie 1 North Waukegan Road North Chicago - USA www.abbvie.com AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. At AbbVie, we have the expertise of a proven pharmaceutical leader and the focus and passion of an entrepreneur and innovator. As a result, AbbVie is a leading company with the stability, resources, expertise and passion to discover, develop and bring to market groundbreaking science to solve the biggest health problems that face the world today and tomorrow. AbbVie employs approximately 25,000 people worldwide and markets medicines in more than 170 countries. Adamas Pharmaceuticals Suite 750, 1900 Powell Street 94608 Emeryville - USA Tel. +1.510.450.3500 Fax +1.510.428.0519 info@adamaspharma.com www.adamaspharma Adamas Pharmaceuticals, Inc. focuses on the development and commercialization of therapeutics for chronic disorders of the central nervous system. ADS-5102, the company’s lead product candidate, is in Phase 3 trials for the treatment of levodopa-induced dyskinesia associated with Parkinson’s disease and a Phase 2 trial for the treatment of major symptoms associated with multiple sclerosis, including walking impairment. The company’s portfolio includes Namzaric™ and Namenda XR®, two FDA-approved products with Forest Laboratories Holdings Limited, an indirect wholly-owned subsidiary of Allergan plc. Please visit www.adamaspharma.com to learn more. 102 XXI World Congress on Parkinson’s Disease and Related Disorders Av. da Siderurgia Nacional 4745-457 Coronado (S. Romão e S. Mamede) Trofa - Porto - Portugal Tel. +351.22.986.6100 Fax +351.22.986.6190 info@bial.com www.bial.com BIAL is an international pharmaceutical company strongly committed to innovation with the mission to discover, develop and provide new therapeutic solutions. Consistently investing more than 20% of its turnover in Research and Development (R&D), BIAL has established an ambitious R&D program centred on the central nervous, cardiovascular system and allergy immunotherapy. The company has developed an antiepileptic drug, (Zebinix - eslicarbazepine acetate) already commercialized in the US market and in several European countries. A second compound from its R&D pipeline for the treatment of Parkinson’s disease, Opicapone, is under review by the European Medicines Agency. BOEHRINGER INGELHEIM ITALIA Via Lorenzini, 8 20139 Milan - Italy Tel. +39.02.5355.1 Fax +39.02.5355.222 info@boehringer-ingelheim.it www.boehringer-ingelheim.it COMPANY PROFILES BIAL abcd The Boehringer Ingelheim group is one of the world’s 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 146 affiliates and more than 47,700 employees. The focus of the family-owned company, founded in 1885, is on researching, developing, manufacturing and marketing new medications of high therapeutic value for human and veterinary medicine. Social responsibility, caring for the employees, environmental protection and sustainability are important elements of the corporate culture. In 2014 company achieved net sales of about 13.3 billion euros. R&D expenditure corresponds to 19.9% of its net sales. 103 XXI World Congress on Parkinson’s Disease and Related Disorders COMPANY PROFILES Britannia Pharmaceuticals Longwater Avenue, 200 RG2 6GP Reading - United Kingdom +44.118.920.9500 events@britannia-pharm.com www.britannia-pharm.com Britannia Pharmaceuticals Limited is a UK based pharmaceutical company specializing in niche innovative products for chronic and serious medical conditions, and in particular, the treatment of patients with Parkinson’s disease. The need for apomorphine as a treatment option for Parkinson’s disease has led to the development of APO-go and other associated brands around the globe, which are available in many countries through our Distribution or Licensing Partners. Canè Medical Technology Via Cuorgnè, 42/a 10098 Rivoli (TO) - Italy Tel. +39.011.957.4872 Fax +39. 011.959.8880 mailbox@canespa.it www.canespa.it Canè was founded in 1978 as manufacturer of ambulatory infusion pumps. Starting from the first syringe-drivers, Canè’s products have evolved into the CRONO line of miniature pumps which may be worn without impacting patients’ normal daily routine. Canè’s CRONO series includes the ambulatory infusion pumps and the dedicated syringes which are used with them. Depending upon the therapy, the syringes may have volumes of 10, 20, 30 or 50 ml. All pump R&D and design work is done in-house, as are final assembly and testing. Canè works with pharmaceutical companies and other medical device manufacturers to provide customized solutions where required. 104 XXI World Congress on Parkinson’s Disease and Related Disorders Rep.: Rhea Rebello Richmond Street West, 828 M6J 1C9 Toronto - Canada Tel. +1.416.703.2449 Fax +1.416.703.8752 rrebello@cynapsus.ca www.cynapsus.ca Cynapsus is a specialty pharmaceutical company that is focused on the clinical and regulatory development of a sublingual apomorphine film strip (APL-130277), for the on-demand turning ON of debilitating OFF episodes associated with Parkinson’s disease (PD). The Company recently completed a Phase 2 clinical trial for APL-130277. Apomorphine is the only molecule approved for acute, intermittent treatment of OFF episodes for advanced PD patients, but is currently only approved as a subcutaneous injection in the United States, Europe, Japan and other countries. Cynapsus’ drug candidate, APL-130277, is a sublingual form of apomorphine that is currently enrolling patients in Phase III clinical studies (clinicaltrials.gov: NCT02469090 and NCT02542696). Cynapsus intends to submit a new drug application in 2016. COMPANY PROFILES Cynapsus Therapeutics ELSEVIER Radarweg, 29 1043 Amsterdam - The Netherlands Tel. + 44.01865.84.3670 a.so-so@elsevier.com www.elsevier.com Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge. Elsevier provides web-based, digital solutions -among them ScienceDirect, Scopus, and Elsevier Research Intelligence. 105 XXI World Congress on Parkinson’s Disease and Related Disorders COMPANY PROFILES Ever Neuro Pharma Rep.: Marie-Kristin Schoeppl Oberburgau, 3 4866 Unterach - Austria Tel. +43.766.520.5550 Fax +43.766.520.555910 office@everpharma.com www.everpharma.com EVER Neuro Pharma is an Austrian pharmaceutical company focused on the field of neuroscience. Based on our experience and proprietary R&D technology platform we develop innovative therapies for neurological disorders. Among other agents our product portfolio is strengthened with Dacepton® (apomorphine hydrochloride) for the treatment of disabling motor symptoms in the advanced stage of Parkinson´s disease. We focus on the complete Package of Care including Medical Devices for the intermittent and continuous drug delivery. Recognizing current trends we keep to our endeavor for further and constant improvement of our patient oriented services. Global Kinetics Corporation Rep.: Stefan Asberg Collins Street Level 15/440 3000 Melbourne – Australia Tel. +46.766.316.112 stefan.asberg@globalkineticscorp.com www.globalkineticscorporation.com Global Kinetics Corporation (GKC) along with the Florey Neuroscience Institute (Australia) has developed the Parkinson’s KinetiGraph™ (PKG™) for objective, ambulatory assessment of movement disorder symptoms in Parkinson’s disease. The PKG™ records a patient’s movement continuously over 7-10 days and reports correlations of fluctuation severity with respect to dosage. The PKG™ provides clinicians with an assessment of a patient’s clinical state which is objective, includes scaled measures of bradykinesia and dyskinesia with repeat reliability, links fluctuations with the timing of medication, is comparable over time and allows assessment during the activities of daily living. 106 XXI World Congress on Parkinson’s Disease and Related Disorders Rep.: Francesco Cecchini Vicolo Nassetta, 2 CH-6900 Lugano - Switzerland Tel. +41.91.921.3838 Fax +41.91.921.3939 info@gondola.org www.gondola-parkinson.com Gondola Medical Technologies SA specializes in restorative therapies for neurological conditions. It has developed the proprietary GONDOLA™ medical device to deliver the AMPS stimulation, an effective treatment for motor symptoms in intermediate and advanced stages of Parkinson’s disease. AMPS is a non-invasive, automated, pressure-based stimulation that allows to: - reduce Freezing of Gait, - improve walking skills, - reduce slowness of movement, - improve balance. The treatment requires less than 2 minutes, its benefits are perceived immediately and last 3 to 5 days after use of the device; regular home use allows to maintain benefits overtime. COMPANY PROFILES Gondola Medical Technologies Medtronic Rep.: Cathy Persidis Route du Molliau, 31 1131 Tolochenaz - Switzerland Tel. +41.21.802.7000 cathy.persidis@medtronic.com www.medtronic.com As a global leader in medical technology, services and solutions, Medtronic improves the health and lives of millions of people each year. We believe our deep clinical, therapeutic and economic expertise can help address the complex challenges - such as rising costs, aging populations, and the burden of chronic disease - faced by families and healthcare systems today. But, we can’t do it alone. That’s why we’re committed to partnering in new ways and developing powerful solutions that deliver better patient outcomes. Founded in 1949 as a medical repair company, we’re now among the world’s largest medical technology, services and solutions companies, employing more than 85,000 people worldwide, serving physicians, hospitals and patients in more than 160 countries. Join us in our commitment to take healthcare Further, Together. Learn more at Medtronic.com. 107 XXI World Congress on Parkinson’s Disease and Related Disorders COMPANY PROFILES Melvin Yahr International Parkinson’s Diesease Foundation Rep.: Alessandro Di Rocco Larkin Dr, 290 10957 Monroe - USA Tel. +1.718.541.3566 Fax +1877.786.5759 This organization, founded by Melvin D. Yahr M.D., strives to support excellence in neurologic training, patient care, and scientific advancement related to Parkinson’s disease and associated motor disorders. Travel grants are offered to neurology residents, fellows and junior researchers enabling them to attend and participate in scientific meetings, thus increasing their understanding of the basic neuroscience underlying Parkinson’s disease. Applications for such financial aid from young physicians and scientists from minority groups, underprivileged communities and developing countries are particularly welcome. The foundation also provides seed money for the start up of innovative laboratory and clinical research projects, and for meetings dedicated to the study of Parkinson’s disease throughout the world. Mundipharma International Rep.: Sara Dickerson Unit 194 Cambridge Science Park Milton Road CB4 0AB Cambridge - United Kingdom Tel. +44(0)1223.424444 sara.dickerson@mundipharma.co.uk www.mundipharma.com 108 The Mundipharma network of independent associated companies consists of privately owned companies and joint ventures covering the world’s pharmaceutical markets. The Mundipharma network has a presence in 51 countries with more than 7,800 employees across the world. These companies are committed to bringing to patients the benefits of pioneering treatment options in the core therapy areas of pain management, oncology, respiratory and inflammatory conditions. Through innovation, design and acquisition, the Mundipharma network of independent associated companies delivers important treatments to meet the most pressing needs of patients, healthcare professionals and health systems worldwide. XXI World Congress on Parkinson’s Disease and Related Disorders Centro Direzionale Colleoni Palazzo Andromeda, 20/3 20864 Agrate Brianza (MB) - Italy +39039607471 sjmnews@sjm.com www.sjm.com What if a company could invent breakthrough technologies that transform the treatment of some of the world’s most expensive epidemic diseases? At St. Jude Medical we are turning what if into why not by partnering with physicians, hospitals and insurers to save and improve millions of lives worldwide – while reducing health care costs for all. St. Jude Medical is committed to meeting or exceeding the high quality and safety expectations of our patients, customers and regulators. Headquartered in St. Paul, USA, St. Jude Medical is focused on six key treatment areas: Heart Failure, Arrhythmias, Vascular Disease, Structural Heart, Chronic Pain, Neurological Diseases. COMPANY PROFILES St. Jude Medical US WorldMeds Ste L07 4010 Dupont Circle 40207 Louisville - USA Tel. +1.866.750.8796 Fax +1. 502.815.8001 wmardis@usworldmeds.com www.usworldmeds.com At US WorldMeds, we hold a fundamental belief that our science has the potential to improve the lives of Parkinson’s patients. US WorldMeds’ commitment to Parkinson’s patients is reflected in all that we do. Our pipeline of development projects, along with our currently available PD treatment, reflects our resolve to bring innovative solutions to Parkinson’s patients. US WorldMeds is proud to be a Sponsor at the XXI World Congress on Parkinson’s disease and Related Disorders. US WorldMeds is committed to supporting patients and care partners to increase Parkinson’s disease awareness and help improve the quality of care. 109 XXI World Congress on Parkinson’s Disease and Related Disorders COMPANY PROFILES Wisepress Medical Bookshop High Path, 25 SW19 2JL London - United Kingdom Tel. +44.208.715.1812 james.davie@wisepress.com www.wisepress.com Wisepress.com, Europe’s leading conference bookseller, has a range of books and journals relevant to the themes of the meeting. In addition to attending 200 conferences per year, Wisepress has a comprehensive medical and scientific bookshop online with great offers. Follow us on Twitter for the latest news @WisepressBooks. ZAMBON Rep.: Maria Grazia Papini Via Lillo del Duca, 10 20091 Bresso Tel. +39.02.66524.1 mariagrazia.papini@zambongroup.com www.zambonpharma.com Zambon is a leading Italian family company that has operated for 109 years in the chemical and pharmaceutical industries. The company is well-established in 3 therapeutic areas: respiratory, pain and woman care. Zambon is also focusing on strengthening the respiratory area with the treatment of severe diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), with the acquisition of Pharma Profile from Philips. Zambon is carrying on the 132 million Euro investments plan for the years 2013 – 2017 in supporting research and development. The Group entered into a new important therapeutic area, the Central Nervous System (CNS), with the molecule Safinamide for the treatment of Parkinson’s disease. The Respiratory Business and CNS are the two main drivers of the development strategy of the company. Zambon, headquartered in Milan, is present in 84 countries with more than 2,600 employees and 19 operating subsidiaries. 110 XXI World Congress on Parkinson’s Disease and Related Disorders ........................................................................................................................................................................... NOTES ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... 111 XXI World Congress on Parkinson’s Disease and Related Disorders NOTES ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... ........................................................................................................................................................................... 112 ........................................................................................................................................................................... XXII World Congress on Parkinson’s Disease and Related Disorders Ho Chi Minh City, Vietnam 12-15 November 2017 Organizing Secretariat Viale Matteotti, 7 50121 Florence, Italy Tel. +39 055 50351 infoiaprd2017@oic.it