2006 Annual Report Ext. Cover
Transcription
2006 Annual Report Ext. Cover
NARSAD The Mental Health Research Association Advancing research with three grant programs funding 718 scientists with $19 million in grants in 2006 Young Investigator Program supporting innovative research ideas of outstanding young scientists Independent Investigator Program building upon established scientific skills and unique investigative insights Distinguished Investigator Program facilitating breakthrough research by proven scientific leaders Accelerating discovery in genetics, molecular biology, bioinformatics, brain imaging and better medications Leading the world in charitable funding of research for mental health Annual Repor t 2006 for illnesses such as schizophrenia; bipolar disorder; depression; anxiety disorders; attention-deficit disorder; autism; eating disorders; and other childhood and adult disorders with researchers in the United States and 25 other countries NARSAD’s mission is to promote human health through advancements in brain and behavior research leading to more effective treatments and cures. Table of Contents About NARSAD Message from the President NARSAD: The Mental Health Research Association is the world’s leading charity for research on mental illnesses. It funds innovative scientific research on the causes, treatment and prevention of a range of serious neuoropsychiatric disorders. From the time it began giving grants in 1987 as the National Alliance for Research on Schizophrenia and Depression, NARSAD had distributed through the end of 2006 nearly $200 million in research funds to 2,284 scientists in 347 institutions in the United States and 25 other countries. NARSAD’s scope of funding now extends well beyond schizophrenia and depression to include bipolar disorder, anxiety disorders, and a range of childhood and adolescent disorders. NARSAD’s research grant programs support the work of outstanding scientists based at universities, medical centers and other nonprofit medical research institutions worldwide. Our Young Investigator grants encourage innovative ideas by talented earlycareer scientists, including many who are just launching research. NARSAD’s Independent Investigator grants sustain the work of mid-career scientists who have established successful research programs and demonstrated unique investigative insights. The Distinguished Investigator program facilitates breakthrough research by leaders in the field. All research grants are reviewed and recommended by NARSAD’s distinguished 94-member Scientific Council. In recent years, NARSAD has become the major nongovernmental source of grants for psychiatric research at leading American universities, including the University of California, Columbia, Harvard and Yale. NARSAD-funded research frequently leads to additional, major funding from the government and other private sources. In part this reflects NARSAD’s success in identifying worthy high-risk, high-reward research projects at their earliest stages of development. The implications are well captured by Steven B. Hyman, provost of Harvard University and a former director of the National Institute of Mental Health: “There is no organization in the United States doing a better job of dealing with the gap between our nation’s real and profound public health needs and our ability to fund research than NARSAD. What NARSAD traditionally has done is to fund young investigators — the source of our innovation and new ideas — in a really generous way.” Page 1 Message from the President of the Scientific Council 5 Twenty Years of Advancing Research 6 New Scientific Council Members 7 Research Highlights 9 NARSAD’s Annual Prizes — The Lieber Prize — The Falcone Prize — The Goldman-Rakic Prize — The Ruane Prize — The Sidney R. Baer, Jr. Prize 12 13 14 15 16 18 Report of the Executive Director 19 The Klerman/Freedman Awards 20 NARSAD Mental Health Research Symposia — New York City 21 — Regional 23 • Every dollar donated to NARSAD goes directly to funding research grants. • NARSAD receives no government funding. • Charity Navigator and The American Institute of Philanthropy, leading evaluators of charitable organizations, have given NARSAD their highest ratings for financial efficiency. NARSAD Community Outreach 26 Research Partners Program 27 2006 Grant Programs 34 NARSAD Grants in 2006 — Distinguished Investigators — Independent Investigators — Second-Year Independent Investigators — Young Investigators — Second-Year Young Investigators 36 36 38 40 48 NARSAD Contributors — Honor Tributes — Memorial Tributes 54 66 67 Independent Auditors’ Report — Financial Statements — Notes to Financial Statements 69 70 72 Message from the President The year 2006 was a special one for NARSAD. It marked the 20th anniversary of the formation of our Scientific Council and its initiation of our research programs. The year was also marked by major research achievements announced and published by many of our grantees, whose work moves us steadily toward our goal of “better treatments and cures for severe mental illnesses.” Our donor base is growing as evidenced by increased number of donors, contributions and endowment. In 2006, NARSAD raised $17.1 million from both new and loyal donors and earned $1.4 million of investment income from its growing endowment. The cumulative amount of funds raised by NARSAD, including special grants designated to cover our entire administrative and overhead expenses, has totaled $222 million since our inception in 1987. NARSAD continues its long-term relationship with two family foundations that have generously committed to underwriting these expenses. Through 2006, NARSAD provided nearly $200 million for 2,948 research grants to 2,284 scientists at 347 universities and medical research institutions in the United States and worldwide. Research Grant Awards In 2006, NARSAD provided $19 million in new research grant funding. The highly selective process employed by the Scientific Council in awarding research grants resulted in only 23 percent of the applicants receiving funding. There were 20 Distinguished Investigator grants provided to leading-edge researchers in a variety of disciplines, including some of the most widely recognized, innovative thinkers in psychiatric and neuroscience research. Each received $100,000 for their special research projects over one year. The Young Investigator program, which we initiated in 1987, awarded grants to 206 early-career scientists, each receiving one- or two-year grants of $30,000 and $60,000 respectively, to enhance their research and accelerate their careers. New grants were also awarded to 46 scientists in the Independent Investigator program, each of whom received $100,000 for a two-year period. Additionally, Young and Independent Investigators from 2005 who were in the second year of their NARSAD research projects received ongoing support. Research Leverage A vital result of NARSAD grants is their role as a catalyst for new research programs. Year after year, NARSAD grantees report that the scientific work accomplished with funding they receive from NARSAD leads to new, often larger grants. In 2006, NARSAD initiated a new survey of such subsequent grants received by NARSAD investigators. Data from the 20 percent of grantees who responded showed that they received subsequent new grant funding equal to 19 times the amount of their original NARSAD grants. In financial terms, this is exceptional leverage, suggesting that NARSAD provides the basis for new and larger research programs. Honoring the Scientific Council NARSAD’s board of directors and supporters honored our Scientific Council’s 20th anniversary as a special component of our annual New York gala in October. The Council, a group of leading scientists covering the broad spectrum of psychiatric and neuroscience research, has provided the grant-making strategies and grantee selection and review process at the core of NARSAD’s achievements. Each of the 94 members of the Scientific Council is a volunteer, generously devoting time and effort to identifyng the most promising research projects. Beginning as a small group in 1986, the Scientific Council has frequently elected new members in order to meet the challenges of fast-developing science and new technologies. In 2006, six new members were added to the Council: 1 Robert W. Buchanan, M.D.; Peter Buckley, M.D.; B. J. Casey, Ph.D.; Richard Keefe, Ph.D.; Godfrey D. Pearlson, M.D.; and Pasko Rakic, M.D., Ph.D. These new members add luster to the Council, which has included three Nobel Prize winners, Eric Kandel, M.D., Paul Greengard, Ph.D., and the late Julius Axelrod, Ph.D., as well as four former directors of the National Institute of Mental Health, among whom is the president of our Scientific Council, Herbert Pardes, M.D. The current NIMH director, Thomas Insel, M.D., previously served on the Council before being appointed to his NIMH post. Thirty-five Scientific Council members, each wearing a ribbon and medallion of honor, joined the 20th anniversary celebration, providing a dramatic moment as they entered the ballroom together to the music of Handel sung by members of “Sing for Hope,” an extraordinary group of professional musicians that frequently performs for charity events. Growing Donor Base Broadening NARSAD’s base of support remained a key concentration throughout the year. We accelerated this effort through new fund-raising events, our publications, increased public participation in our annual schedule of regional events and our websites — all creating a major impact. There were two additions to our events calendar in 2006: NARSAD’s inaugural Los Angeles “Campaign for the Brain — Silver Ribbon Weekend” and the first annual Boston Mental Health Research Symposium and Dinner. 2 The Los Angeles “Campaign for the Brain – Silver Ribbon Weekend” events brought the NARSAD message to Southern California under the leadership of Hal and Patsy Hollister, whose founding and development of NARSAD Artworks is legend in Los Angeles and well known throughout the country. The June weekend opened with a gala dinner, at Paramount Studios in Hollywood, that honored former first lady Rosalynn Carter for her achievements in the mental health field. The dinner was followed the next day by a free public symposium which was held in Royce Hall at University of California, Los Angeles, and led by Lewis Baxter, M.D., and renowned NARSAD prize-winning scientist Kay Redfield Jamison, Ph.D. The initiation of a NARSAD symposium and dinner in Boston in April was, in a special sense, a homecoming. No other community has received as many NARSAD grants as Boston, with a total of 362 to date representing more than $15 million. The medical research institutions in Boston have fostered the scientific promise sought by NARSAD’s Scientific Council. Our free public symposium was funded by the Sidney R. Baer, Jr. Foundation, which also provided generous support to the third annual Mental Health Research Symposium and Dinner in St. Louis, Missouri. Lee and Robert Peterson, long-time leaders of NARSAD’s board, organized their ninth annual “Sunshine from Darkness” Symposium and Gala in Sarasota, Florida. Once again this event attracted over 1,200 participants. The gala dinner honored NARSAD’s renowned humanitarian awardee Mike Wallace. February brought NARSAD’s third annual “Mission Possible” weekend in Washington, D.C. The leadership of this event by board member Sheila Rabaut guaranteed an extraordinary dinner in the Andrew W. Mellon Auditorium with Dr. Thomas Insel, director of the National Institute of Mental Health, as honoree. Dr. Insel also moderated the weekend’s free public symposium, which featured presentations on childhood and adolescent disorders by NARSAD Scientific Council members and grantees, all outstanding scientists. Photos top to bottom: Patsy Hollister, Hal Hollister, Lee and Bob Peterson, Sheila Rabaut with CNN correspondent and emcee for the event, Frank Sesno, and committee chair Wendy Adeler-Hall. The winter-season achievements of NARSAD’s volunteer leaders culminated in the Palm Beach “Sunshine from Darkness” Gala and Symposium, organized for the third year by Sallie and Alex Van Rensselaer. The gala, which was set at the luxurious and renowned Mar-a-Lago, was a high point of the resort’s charity season. The gala was further distinguished by its honoree, CNN’s Anderson Cooper, who spoke movingly about his brother’s mental illness. The following day, a free public symposium for the community offered an outstanding panel of NARSAD researchers. The annual meeting of NARSAD’s board of directors and Scientific above: Council in July featured the presentation of the 2006 Peterson Award Sallie and Alex Van to Mary and Mike Wallace. Both have used their great talents in behalf Rensselaer of NARSAD and its cause. Mary has served as a member of NARSAD’s left: Anderson Cooper board and Mike has been a powerful speaker and leader on the challenges of mental illness and the potential for recovery. (Both also spoke in a NARSAD co-sponsored public television series on mental illness, “Healthy Minds,” which made its debut in 2006.) Through the Peterson Award, the board of directors continues to honor those who work in the spirit of esteemed long-time supporters and board leaders Lee and Bob Peterson. The Gala Awards Celebration NARSAD’s 19th annual New York Gala took place at the Pierre Hotel in October. It celebrated the Scientific Council’s 20th anniversary, and also honored the six scientists receiving NARSAD prizes for outstanding achievement in brain and behavior research. The Lieber Prize for Schizophrenia Research was awarded to Jeffrey Lieberman, M.D., of Columbia University; the Falcone Prize for Affective Disorders Research went to Lori Altshuler of UCLA; the Ruane Prize for Child and Adolescent Psychiatry was awarded to David Shaffer, M.D., of Columbia University and David Brent, M.D., of the University of Pittsburgh; the Goldman-Rakic Prize for Cognitive Neuroscience Research was presented to Joaquin Fuster, M.D., Ph.D., of the University of California at Los Angeles; and the Sidney R. Baer, Jr. Prize went to Lorna Role, Ph.D., of Columbia University. The weekend began with NARSAD’s annual all-day Young Investigator Symposium on Friday, and continued Saturday morning. Over 1,000 attendees participated in these free symposium events. Research Partners Program Many other events and initiatives characterized NARSAD’s 2006 achievements, as will be detailed in this report. Among the most promising is the continued success of our Research Partners Program, which allows donors to support the research of a particular scientist. Currently, the research of 126 investigators is being supported by a wide range of individual donors and foundations. Some of these donors are especially interested in supporting the research project of a particular investigator, while others choose to support work at an institution about which they care (often as an alumnus). Still others wish to accelerate research in a particular field, such as research on autism or obsessivecompulsive disorder or bipolar disorder. Importantly, the Research Partners Program has become an increasingly popular philanthropic vehicle for charitable foundations that wish to support NARSAD and share a commitment to our goals. Many of these foundations recognize that NARSAD’s grant-making structure allows them greater ability to select the research and researchers most relevant to them and to obtain a better range of grant applicants than their own structure can provide. Typically, we learn that foundations have but one or two scientific advisors, and lack the breadth of expertise and grant-selection capability held by our Scientific Council. We are deeply appreciative of this broadening institutional recognition of the potential to support the best research through NARSAD’s grants program. 3 Information Resources NARSAD’s publications and other informational resources continue to serve as a vital link between our supporters and our scientists and provide information for the broader public. In the pages of NARSAD’s quarterly Research Newsletter, we were privileged to report on the extraordinary careers of the exceptional scientists who received NARSAD research prizes in 2006. We added an important dimension to the Newsletter’s reporting on the Young Investigator symposium by including commentaries from senior members of our Scientific Council, all distinguished teachers. Throughout the year, biographical profiles were featured on highly accomplished leaders in research who are members of the Scientific Council. The Schizophrenia Research Forum (SRF), which is co-sponsored by NARSAD, marked its second year of service in providing a virtual meeting place for the exchange of scientific information by investigators involved in psychiatric and cognitive research. The SRF website enjoyed a record number of visitors. Similarly, the newly revised NARSAD website offered a constant stream of information on new research findings by NARSAD-supported scientists, including reports on presentations at our research symposia held in cities around the country. A New President The year 2006 marked an important transition for NARSAD as the Board of Directors initiated a search for a full-time president and chief executive officer. Having held responsibility as president and C.E.O. since 1989, I look forward to seeing NARSAD achieve another level of growth under full-time professional leadership, augmenting our already excellent staff and programs. The conclusion of the presidential search was announced on May 21, 2007, with the appointment of Geoffrey Birkett. Mr. Birkett previously served as a senior vice president of global marketing for AstraZeneca Pharmaceuticals, where his portfolio included central nervous system medications. The majority of his career has been in the pharmaceutical industry, with particular emphasis on psychiatric drugs. He has held positions at Eli Lilly and Company, Lundbeck Pharmaceuticals, Glaxo Group Limited, and, for the last 15 years, AstraZeneca. We look forward to NARSAD receiving the benefit of his considerable experience in key areas of related pharmaceutical research, information technology and marketing. 4 As we move to the next stage of achieving NARSAD’s ambitious goals, I look forward to continuing to serve the organization as a member of the board of Geoff Birkettt directors. In closing, I thank our wonderful, enthusiastic supporters, our remarkable Scientific Council, our distinguished board of directors, and, particularly, our staff, for the opportunity to provide leadership over 18 years. I look forward to continuing cooperation with all. Above all, I have deep thanks for the many who shared in NARSAD’s efforts to enhance and accelerate the mission to build knowledge which will bring “better treatments and cures for severe mental illnesses.” With striking scientific progress in 2006, and with our great cadre of scientist-grantees and new NARSAD leadership, we will meet the goals of our mission. In closing, we and our grantees are deeply grateful to those whose gifts to NARSAD of funds, time and energy have made possible the achievements that are reported in the balance of this document. Your dedication, your belief in progress and your desire to enhance the lives of those who suffer are the inspiration for the effort of this entire organization. Sincerely, Constance E. Lieber President, NARSAD Message from the President of NARSAD’s Scientific Council Given all the current demands on our government’s revenues, it’s no surprise that the National Institutes of Health (NIH), our federal agency for medical research, once again is faced with extraordinary budget constraints. Many researchers of psychiatric disorders are experiencing considerable difficulty in finding support for their research. In this period of tight budgets, NARSAD has an even more vigorous role to play as a private source of research grants. My hope is that we will see some turnaround in NIH funding as a result of impending political changes in Washington. But regardless of what happens in the corridors of government, NARSAD is poised to grow and increase the pool of private funding for critically needed research on mental illnesses. Among the important developments at NARSAD is the naming of a superb new president, Geoff Birkett, who is an experienced and sophisticated leader. Additionally, Connie Lieber, who led NARSAD as president during the past 18 seminal years of this organization’s development, along with the other members of our board of directors, will continue to serve and support the organization in a vital capacity. This will enable NARSAD to sustain its high standards for grant-making and organizational operations and reach for even greater heights. The board is currently studying ways in which to amplify NARSAD’s impact on the pace and scope of research on psychiatric illnesses. The Scientific Council stands ready to help in every way possible. All this good news comes at a time when the potential for research breakthroughs, given recent advancements in science, has never been more promising. The moment holds great implications for the field of neuroscience and for the fight against mental illness. On behalf of the Scientific Council, we look forward to further expanding and enhancing NARSAD’s contributions to psychiatric research by capitalizing on the strengths of our Scientific Council, board of directors and new leadership. Thank you to everyone who is helping. This is one great family. Sincerely, Herbert Pardes, M.D. President and CEO, NewYork-Presbyterian Hospital 5 Front row, l-r: Drs. Nina Schooler, Rachel Klein, Nancy Andreasen, Pierre Blier, NARSAD’s President, Connie Lieber, Drs. Eric Kandel and Ariel Deutch. Back row, l-r: Drs. Godfrey Pearlson, Francine Benes, Bita Moghaddam, Peter Buckley, Peter Kalivas, Judith Rapoport, Michael Posner, J. John Mann, David Lewis, Anthony Grace, William Carpenter, Herbert Meltzer, Robert Kessler, Herbert Pardes, Jeffrey Lieberman, Fred Goodwin, Lewis Judd, Fritz Henn, Jack Barchas and Samuel Barondes. Celebrating Twenty Years of Advancing Research NARSAD’s research program was developed and continues to be led by its illustrious Scientific Council, now comprising 94-members. In 2006, NARSAD marked the Council’s 20th anniversary at its annual New York Gala. 6 The Council has been instrumental in guiding NARSAD’s growth from a program of funding 10 investigators in 1987 to 718 investigators in 2006. It identifies new frontiers for research, sets grantmaking policy, and rigorously reviews more than 1,000 grant proposals annually, recommending hundreds for funding. Its members also select the recipients of NARSAD’s career achievement prizes. Over the years, these recipients have included three scientists who subsequently were honored with Nobel Prizes. Scientific Council members who attended the October 27th gala at the Pierre Hotel were presented with commemorative medallions by NARSAD President Connie Lieber in recognition of their service. In honoring the body’s long record of achievement, the Council’s founding president, Herbert Pardes, M.D., looked back over its first two decades of work: “On July 24, 1986, the first full meeting of NARSAD’s Board of Directors and Scientific Council took place. I was privileged to be among the organizers and to become the Council’s president. Floyd Bloom, M.D., of the Scripps Clinic and Research Foundation, was selected to serve as vice president, and Julius Axelrod, Ph.D., of the National Institute of Mental Health, and Eli Robins, M.D., of Washington University, as honorary chairs. By the end of 1987, there were 24 members of the new Council providing expert guidance to NARSAD in the key areas of psychiatric research. “In my first annual report on the work of the Scientific Council, I stated — and I now reiterate: NARSAD stands as a symbol that the nation and its citizens are dedicated to the proposition that psychiatric illnesses can be ameliorated, and will, in the end, be extinguished. “Now numbering 94 members, the Council is widely recognized as a premier group of research and research administrative leaders covering a broad spectrum of brain and behavioral science. Each member volunteers his or her services in essential ways. The Council’s members review each year’s growing number of grant applications and select the very best research on psychiatric disorders, wherever it is done, regardless of discipline or location, focusing only on excellence. The Council also serves as an advisory group on policy and programs for NARSAD, and has facilitated important interactions with other entities concerned with psychiatric research. “All this has been accomplished as a result of the dedication, commitment and expertise of my distinguished Council colleagues, whose work represents a unique gift to those suffering from severe mental illnesses. Their contribution also represents an asset to a society that urgently needs to meet NARSAD’s original goal of productive scientific research to find the causes, cures and prevention of chronic and severe mental illnesses.” New Scientific Council Members The Scientific Council has never rested on its laurels. Each year, it effectively revivifies itself by electing some of the emerging leaders in neuropsychiatric research to join its ranks. This past year was no exception, with six outstanding individuals joining the Council, bringing its total membership to 94. Like those who elected them to serve, new council members are rich in talent and varied in backgrounds. And if past is prologue, they, too, will not only play a vital role in annually identifying the most promising research projects for NARSAD funding, but will also give their time as commentators and moderators for NARSAD’s public symposia on mental health research, and will serve as mentors to NARSAD Young Investigators. Robert W. Buchanan, M.D., is professor of psychiatry and chief at the Maryland Psychiatric Research Center Outpatient Research Program, University of Maryland School of Medicine, Baltimore. His research interests include neurobehavioral and neuroanatomical investigations of the pathophysiology of schizophrenia and investigation of new pharmacological approaches for treating cognitive impairments and treatmentresistant symptoms in schizophrenia. Dr. Buchanan has been involved in multiple aspects of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) project, including identification of potential pharmacological targets for treating cognitive impairments. He received a NARSAD Young Investigator Award in 1988. Peter F. Buckley, M.D., is professor and chairman of psychiatry at the Medical College of Georgia. With a background of studies in brain imaging and neurodevelopment, he is currently conducting a program of research on the neurobiology and treatment of schizophrenia. Dr. Buckley has been a professor and vice chair in the department of psychiatry at Case Western Reserve University School of Medicine and medical director at Northcoast Behavioral Healthcare System, the adult state psychiatric services for Cleveland and Toledo. He chairs the schizophrenia spectrum disorders and late-life review committee of the National Institute of Mental Health and has contributed to several expert consensus guidelines. Dr. Buckley received a NARSAD Young Investigator Award in 1992. B. J. Casey , Ph.D., is Sackler Professor of Developmental Psychobiology and director of the Sackler Institute for Developmental Psychobiology at Weill Medical College of Cornell University. She is also a visiting research collaborator in the psychology department of Princeton University. Dr. Casey’s research focuses on inhibitory mechanisms of attention, particularly their neurobiological basis, development and pathology. She studies the normal development of brain circuitry involved in inhibitory control and behavioral regulation and how disruptions in these brain systems (in the prefrontal cortex and basal ganglia) can give rise to a number of developmental disorders. Having published the first fMRI study with children, Dr. Casey continues to be a pioneer in the study of human brain development and behavior using noninvasive neuroimaging techniques and is moving toward relating these measures to genetics. 7 New Scientific Council Members Richard Keefe, Ph.D., is associate professor of psychiatry and behavioral sciences at Duke University Medical Center. Through his research, Dr. Keefe is trying to understand cognitive dysfunction in patients with schizophrenia and related disorders, and in people at high risk for them, and to improve treatment for cognitive deficits. He has been particularly involved in designing methods to assess cognitive change and has led the development of batteries of tests for several multi-site studies of responses to cognitive dysfunction treatment, including the National Institute of Mental Health’s CATIE (Clinical Antipsychotic Trials in Intervention Effectiveness) Project, and BACS (Brief Assessment of Cognition in Schizophrenia). Dr. Keefe received NARSAD Young Investigator Awards in 1991 and 1995. 8 Godfrey D. Pearlson M.D., is professor of psychiatry at Yale University School of Medicine and director of the Olin Neuropsychiatry Research Center at Hartford Hospital’s Institute of Living. The mission of the neuroscientists at the Olin Neuropsychiatry Research Center, recently founded by Dr. Pearlson, is to study severe psychiatric illnesses and rapidly translate their findings into new, effective treatments. In the center’s four component laboratories, he and colleagues are applying brain imaging techniques to a broad variety of neuropsychiatric conditions, from childhood to old age, including dementias, mood disorders, substance abuse problems, autism, schizophrenia, attention-deficit hyperactivity disorder, post-traumatic stress disorder and psychopathy. Dr. Pearlson received a NARSAD Distinguished Investigator Award in 2000. Pasko Rakic, M.D., Ph.D., is the Duberg Professor of Neurobiology and Neurology, chairman of the department of neurobiology and director of the Kavli Institute for Neuroscience at Yale University. His research focus is the development of the cerebral cortex and the regulation of neuron production and cell interactions during their migration to the cerebral cortex. He and his colleagues have identified and characterized a number of genes and molecules involved in regulating neuron proliferation, migration, differentiation, and death, and are studying molecular factors regulating the rate of neuronal movement and the “stop signal” for determining their final position. His studies in various mammalian species have led to new hypotheses of cortical development and evolution. 2006 N A R S A D Research Highlights Research findings by NARSAD grantees were essential to scientific advances in psychiatry and neuroscience in 2006. Throughout the year, their articles appeared in publications of the leading journals in the field. Highly rated articles (cited as “Impact Factors”) appeared in journals ranging from Behavioral Genetics, Bioinformatics, Cell, and the American Journal of Psychiatry to multidisciplinary journals such as Science and Nature, as well as those specializing in the neurosciences such as Neuron and Psychoneuroendocrinology. Articles were published, too, in such key journals as the Archives of General Psychiatry and Biological Psychiatry. Widely read medical publications led by the New England Journal of Medicine highlighted important advances reported by NARSAD researchers. This annual summary offers introductory highlights of important research published by a selection of NARSAD grantees. Our aim is to suggest the extraordinary breadth of NARSAD research, ranging from the epidemiology of depression, to gene variance in autism, to risk genes for schizophrenia. Selected Achievements of NARSAD Investigators, 2006 Antipsychotic Drugs Violent Behavior A landmark study aimed at enhancing treatment with antipsychotic drugs was published in the American Journal of Psychiatry by a research group under the leadership of Jeffrey A. Lieberman, M.D., NARSAD Distinguished Investigator, Scientific Council member and winner of the 2006 Lieber Prize for Schizophrenia Research. This study examined the comparative effectiveness of so called first-generation antipsychotic drugs versus that of the newer “atypical” antipsychotics that have been increasingly prescribed and widely used over the last two decades. The study’s initial reports had indicated that there were no differences in effectiveness between the first- and secondgeneration antipsychotics. Understanding of the basic causes of violence and aggression has long been a goal for scientists. A new and promising approach to the problem was disclosed in a study by Andreas Meyer-Lindenberg, M.D., of the National Institute of Mental Health (NIMH), who received a NARSAD Young Investigator Award in 2000. He and his colleagues reported that a computer-based neuroanatomical method (which measures differences in concentrations of brain tissue) and functional magnetic resonance imaging allowed them to study the role of a key enzyme associated with violent behavior. This enzyme, monoamine oxidase A, when accompanied by a gene variation which lowered its expression, resulted in significant structural and functional brain differences, impacting the ability to regulate emotional and aggressive responses. Significant differences did appear, however, in a slightly lower rate of discontinuation by patients on major atypical medications compared to other drugs, although their use was associated with unwanted weight gain and metabolic side effects. The study found that patients with chronic schizophrenia were more likely to continue treatment if they were taking the drugs olanzapine (Zyprexa) and risperidone (Risperdal) rather than other atypical antipsychotic drugs. It further confirmed that for patients who did not respond to previous atypical antipsychotic medications, the drug clozapine (Clozaril) offered a better response than did second-generation atypical antipsychotics with which it was compared. Bipolar Genetics A new gene linked to bipolar disorder was found in a collaboration by Hugh Gurling, M.D., a NARSAD Distinguished Investigator at University College in London, and his colleague, Professor Ole Mors, at the University of Aarhus in Denmark. The gene, known as slynar, is found on chromosome 12 and appears to be present in around 10 percent of people with bipolar disorder. The finding could lead to new treatments for depression and bipolar disorder, including preventive strategies. 9 2006 N A R S A D Research Highlights Maternal Depression A central issue in the study of depression in children has been the impact of parents who may also be depressed. Myrna Weissman, Ph.D., of Columbia University, a NARSAD Distinguished Investigator and Scientific Council member, headed a study on this issue reported in the Journal of the American Medical Association. Dr. Weissman observed that when mothers were successfully treated with medication for depression over a three-month period, their children showed a reduction in diagnoses of depression and other psychiatric disorders. The study also noted that children of mothers who remained depressed were at increased risk for depressive and other symptoms. Cognition in Schizophrenia 10 One of the great challenges in developing an understanding of psychiatric disorders is the creation of animal models that enable studies of brain impacts and development. The engineering of a mouse model to mimic the cognitive aspects of schizophrenia was accomplished by researchers at Columbia University under the leadership of Nobel laureate Eric R. Kandel, M.D., a NARSAD Distinguished Investigator and Scientific Council member. He and NARSAD investigators Christoph Kellendonk, Ph.D., and Holly Moore, Ph.D., and associates, developed a mouse strain characterized by abnormal activity of the dopamine system in a specific part of the brain causing cognitive and behavioral impairments mimicking those in people with schizophrenia. The research team’s findings suggest that cognitive symptoms of schizophrenia may arise from subtle genetic differences in the dopamine receptor gene that increase receptor activity in people with schizophrenia. Depression Treatment Protein Target A protein that seems to play a role in the lifting of depression has been discovered. The research work, in mice, was led by Nobel laureate Paul Greengard, Ph.D., of Rockefeller University, a NARSAD Distinguished Investigator, Scientific Council member and winner of the Lieber Prize for Schizophrenia Research in 1996. Dr. Greengard’s discovery of a protein called p11 may provide a more specific target for new treatments for depression, anxiety disorders and other psychiatric conditions thought to involve malfunctions in the serotonin system. Antidepressants and Children The widely discussed issue of possible negative consequences of antidepressant treatment for children was reported in the Archives of General Psychiatry by Mark Olfson, M.D., of Columbia University, a NARSAD investigator. His case-control study focused on the relationship of antidepressant treatment to suicide attempts and deaths in adults and children. It concluded that although treatment with antidepressant medication was not associated with either suicide attempts or death in adults, it was significantly associated with both in children and adolescents. Gene Variant for Autism A gene variant that more than doubles the risk of autism was found in a study by Phillip Ebert, Ph.D., and Pat Levitt, Ph.D., NARSAD investigators and colleagues at the Vanderbilt University Kennedy Center for Research on Human Development. Their finding provides new insights into the genetic basis of this complex disorder. They report that a genetic variant associated with the MET gene is common in children with autism and appears more frequently in families that have more than one affected child. Significantly, the study concluded that people with two copies of the variant were 2.27 times as likely to have autism as members of the general population, while individuals with only one copy were at 1.67 times normal risk. These findings significantly further the investigation of the interaction between genes and environmental factors in autism. Cellular Targets for Depression Amygdala Shrinkage in Autism New research has identified which among several different kinds of cells in the brain is the chief target of the widely prescribed antidepressant Prozac. The discovery was made by Grigori Enikolopov, Ph.D., of Cold Spring Harbor Laboratories, a NARSAD Independent Investigator. It may enable a new generation of more specific treatments for depression, with fewer side effects. It also lays the foundation for studies of how, when, and where neurons are generated from stem cells in the brain. Researchers have found that the amygdala, the brain’s fear center, likely becomes abnormally small in the most severely socially impaired males with autism spectrum disorders. They have also linked such shrinkage to impaired verbal social behavior in early childhood. These findings were reported in studies led by Richard J. Davidson, Ph.D., of the University of Wisconsin, a NARSAD Distinguished Investigator, and colleagues, including Kim Dalton, Ph.D., a 2005 NARSAD Young Investigator. They provide the first evidence linking objective measures of social impairment and amygdala structure and related brain function in autism. Neuregulin-1 Gene Expression NARSAD researchers have discovered how certain genes work at the molecular level to increase the risk of schizophrenia. Their findings are among the first to suggest a biological basis for two of the most compelling schizophrenia risk genes. Previous genetic studies have identified two genes as schizophrenia risk genes — Disrupted-in-Schizophrenia-1 (DISC-1) and Neuregulin-1 — but the way in which they work has been unclear. DISC-1 is important for brain development, particularly the development of the limbic system, the brain’s memory and emotion “hub.” Neuregulin-1 controls the wiring of the brain during development, communication between nerve cells, and adaptation to new situations. A study led by NARSAD investigators Barbara Lipska, Ph.D., Amanda J. Law, Ph.D., and Daniel R. Weinberger, M.D., a NARSAD Distinguished Investigator and member of the Scientific Council, suggests that in patients with schizophrenia, altered Neuregulin-1 expression likely disrupts the gene’s signaling, which affects brain development and plasticity, thus contributing to the development of the disease. A Gene Controlling Fear A gene that controls both innate and learned forms of fear has been identified in a collaborative study by Nobel laureate Eric Kandel, M.D., of Columbia University, a NARSAD Distinguished Investigator and Scientific Council member, and colleagues, including Gleb R. Shumyatsky, M.D., a NARSAD Young Investigator, and Vadim Volshakov, M.D., a NARSAD Independent Investigator at Harvard Medical School. They identified the gene — known as stathmin or oncopotein18 — as highly concentrated in the amygdala, a key region of the brain that deals with fear and anxiety. The study provides genetic evidence that amygdala-enriched stathmin is required for the expression of innate fear and formation of memory of learned fear. It will provide important information on how learned and innate fears are experienced and processed, and may point the way to new therapies. 11 For Outstanding Achievement in Psychiatric Research NARSAD’s Annual Prizes NARSAD awarded psychiatry’s leading prizes for career achievement in research to six distinguished scientists at the organization’s 19th Annual New York Gala, held October 27th. Those honored were selected by members of NARSAD’s Scientific Council. NARSAD initiated its series of annual prizes in 1987 with the introduction of the Lieber Prize for Outstanding Achievement in Schizophrenia Research. Four other prizes have been established over the years, and to date, 71 scientists have been honored, two of whom have subsequently received the Nobel Prize. The six awardees for 2006 are among the world’s most innovative investigators of schizophrenia, mood disorders, childhood and adolescent psychiatric disorders and cognitive neuroscience. The prizes, widely considered among the most prestigious in the field of neuropsychiatric research and totaling $230,000, recognize exceptional contributions to the understanding and treatment of psychiatric disorders. The prizes and their 2006 recipients are: 12 The Lieber Prize for Outstanding Achievement in Schizophrenia Research Jeffrey A. Lieberman, M.D. The Falcone Prize for Outstanding Achievement in Affective Disorders Research Lori L. Altshuler, M.D. The Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience Joaquin M. Fuster, M.D., Ph.D. The Ruane Prize for Outstanding Achievement in Child and Adolescent Psychiatric Research David A. Brent, M.D., and David Shaffer, M.D. The Sidney R. Baer, Jr. Prize Lorna W. Role, Ph.D. Scientific Council president Herbert Pardes, M.D., described the prizewinners as “scientists who have demonstrated the highest levels of commitment to research and devised outstanding approaches to our understanding and treatment of an area of human illness more devastating than any other.” The Lieber Prize for Outstanding Achievement in Schizophrenia Research Jeffrey A. Lieberman, M.D. Dr. Lieberman has made a major scientific impact on our understanding and treatment of schizophrenia through a series of systematic studies focused on elucidating the psychobiology in first-episode patients. His research has demonstrated progressive changes in brain morphology in these patients. Recently, Dr. Lieberman has served as principal investigator of the largest randomized clinical trial in schizophrenia, the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), sponsored by the National Institute of Mental Health. — William E. Bunney, Jr., M.D. Martin Chair of Psychiatry, University of California, Irvine; Chair, NARSAD Scientific Council Lieber Prize Selection Committee 13 Jeffrey A. Lieberman, M.D., is Kolb Professor and chairman of the department of psychiatry at Columbia University’s College of Physicians and Surgeons; director of the New York State Psychiatric Institute; Lieber Professor and director of the Lieber Center for Schizophrenia Research, at Columbia; and psychiatristin-chief at the Columbia University Medical Center of the NewYork-Presbyterian Hospital. A graduate of the George Washington School of Medicine, Dr. Lieberman received his training in psychiatry at St. Vincent’s Hospital and Medical Center of New York Medical College. Before moving to Columbia University in 2005, he was the Thad and Alice Eure Distinguished Professor of Psychiatry, Pharmacology and Radiology and vice chairman for research and scientific affairs at the University of North Carolina School of Medicine in Chapel Hill. Previously, he was on the faculties of Albert Einstein College of Medicine and Mount Sinai School of Medicine, and served as director of research at the Hillside Hospital of Long Island Jewish Medical Center. Dr. Lieberman’s research has advanced our understanding of the development and course of schizophrenia and the mechanisms and effectiveness of antipsychotic drugs for treating the disease. His work has been reported in more than 200 scientific articles and he has edited or co-edited eight books. He also serves, or has served, as associate editor of eight journals, including the American Journal of Psychiatry, Biological Psychiatry and Neuropsychopharmacology. Dr. Lieberman received a NARSAD Distinguished Investigator Award in 1999 and is a member of the Institute of Medicine of the National Academy of Sciences. The Falcone Prize for Outstanding Achievement in Affective Disorders Research Lori L. Altshuler, M.D. Dr. Lori Altshuler has been awarded the Falcone Prize for her outstanding achievements in improving the understanding and treatment of patients with the severe mood disorders of recurrent unipolar depression and bipolar illness. She has uncovered brain mechanisms involved in these disorders, using static and functional brain imagery techniques that revealed abnormalities in temporal lobe structure, particularly the amygdala. Her work in therapeutics has been equally stellar, describing a range of interventions for depression, mania and their co-morbidities. She found that even mild depression has striking effects on quality of life, and she has studied and found medications that assist in achieving full remission by treating the symptoms of anxiety, obesity, fatigue, and poor concentration. She also has conducted vital studies of the effects of illness and medications on women's endocrine and reproductive function, most recently finding that pregnancy does not protect women who stop antidepressant medication from recurrent depression. 14 Robert M. Post, M.D. Professor of Psychiatry, Penn State College of Medicine; Head, Bipolar Collaborative Network; Chair, NARSAD Scientific Council Falcone Prize Selection Committee Lori L. Altshuler, M.D., is Gouw Chair in Mood Disorders, professor of psychiatry and biobehavioral sciences, director of the Mood Disorders Research Program, and director of the Women's Research Program at the Jane & Terry Semel Institute for Neuroscience & Human Behavior of the Geffen School of Medicine at the University of California, Los Angeles. She is also chief of the Bipolar Disorders Clinic at the Greater Los Angeles Veterans Administration Healthcare System. After earning her M.D. at Cornell Medical College, Dr. Altshuler completed her internship and residency at UCLA. She was appointed to the UCLA faculty in 1989, following a fellowship in the Biological Psychiatry Branch at the National Institute of Mental Health. Dr. Altshuler has received numerous grants to study the treatment of bipolar disorder and the underlying functional neuroanatomic abnormalities in patients in different mood states. In 1990, NARSAD awarded Dr. Altshuler her first research grant, later followed by a NARSAD Independent Investigator Award in 1998 and a Distinguished Investigator Award in 2006. She also has received National Institute of Mental Health grants to study depression in women during pregnancy and the postpartum period, and has enjoyed a career NIMH award since 2000 for her study of the neuroanatomic underpinnings of bipolar disorder. Among many other honors, Dr. Altshuler became a Distinguished Fellow of the American Psychiatric Association in 2003. She has published more than 150 articles in peer-reviewed publications and serves on the editorial boards of several professional journals. The Goldman-Rakic Prize for Outstanding Achievement in Cognitive Neuroscience Joaquin M. Fuster, M.D., Ph.D. A brilliant neuroscientist whose pioneering research has advanced our understanding of the cerebral cortex, Dr. Fuster has focused on studying the mechanisms of cognitive functions. He has investigated fundamental processes that are critically altered in mental illness, such as attention and memory, as well as the integration of information across different sensory modalities. The techniques, findings and conceptual ideas that he has developed and published in a series of definitive papers and compelling books have had a profound influence on scholars worldwide. His work is directly related to disorders such as schizophrenia and will provide a key to the development of more effective modes of understanding, treatment and rehabilitation. — Jack D. Barchas, M.D. Henry Professor and Chair of Psychiatry, Weill Medical College of Cornell University; Psychiatrist-in-Chief, New York Weill Cornell Medical Center of NewYork-Presbyterian Hospital; Chair, NARSAD Scientific Council Goldman-Rakic Prize Selection Committee Joaquin M. Fuster, M.D., Ph.D., is professor of psychiatry and biobehavioral science at the University of California, Los Angeles, where he also serves on the medical school faculty and is a member of the Brain Research Institute and the Semel Institute for Neuroscience & Human Behavior. Building on a halfcentury of seminal research at UCLA on the functions of the brain’s frontal lobe, Dr. Fuster is currently investigating the relationships between neural activity and cortical blood flow in working memory. a two-year stay as a visiting scientist at the Max Planck Institute for Psychiatry, in Munich. At UCLA in 1970 he discovered, in the primate prefrontal cortex, socalled memory cells, which retain information for prospective actions. Because of their time-bridging capability, these nerve cells of the prefrontal cortex are widely considered fundamental to the frontal lobe’s cognitive functions and to the planning, language, and reasoning abilities that are so severely affected in schizophrenia. Dr. Fuster earned his M.D. from the University of Barcelona, in his native city, and his Ph.D. from the University of Granada. He did his internship at the University of Barcelona and residency in the Neuropsychiatric Hospital of the University of Innsbruck, Austria. He moved to UCLA following Dr. Fuster has published hundreds of articles in professional journals and is the author of several books. He is an honorary member of the Spanish Royal Academy of Medicine and of the European Brain and Behavior Society, and the recipient of numerous national and international prizes and awards. 15 The Ruane Prize for Outstanding Achievement in Child and Adolescent Psychiatric Research David A. Brent, M.D. David Shaffer, M.D. Dr. Shaffer and Dr. Brent have devoted their professional lives to the study of the diagnosis, treatment and prevention of childhood depression and suicide. Both have explored the issue from several aspects, including epidemiology, drug and non-drug treatment, support for advocacy groups, and public education. The work of these leaders in child psychiatry has had great influence on today’s educators and practitioners. — Judith L. Rapoport, M.D. Chief, Child Psychiatry Branch, National Institute of Mental Health; Chair, NARSAD Scientific Council Ruane Prize Selection Committee l - r: David A. Brent, M.D. and David Shaffer, M.D. 16 David A. Brent, M.D., holds an endowed chair in suicide studies at the Western Psychiatric Institute and Clinic of the University of Pittsburgh School of Medicine, where he is also academic chief of the division of child and adolescent psychiatry, director of services for teens at risk and professor of child psychiatry. A graduate of Jefferson Medical College, in Philadelphia, Dr. Brent did his internship in pediatrics and a fellowship in psychosocial pediatrics at the University of Colorado Medical Center. Following a residency in child and general psychiatry at the Western Psychiatric Institute, he joined the institute’s faculty, where he has remained during the quartercentury since. He also holds University of Pittsburgh appointments as professor of pediatrics at the Children’s Hospital of Pittsburgh and professor of epidemiology at the Graduate School of Public Health, from which he earlier earned a master of science degree in psychiatric epidemiology. The focus of Dr. Brent’s research efforts has been to understand adolescent depression and suicidal behavior and to translate research findings into prevention and treatment. His research group has conducted psychological autopsy studies that have helped to establish the role of mood disorder, substance abuse, impulsive aggression, parental suicidal behavior and access to guns as risk factors for adolescent suicide. A series of family studies growing from this work has shown that suicidal behavior aggregates in families, and that the familial transmission of earlyonset suicidal behavior appears to be mediated by the transmission of impulsive aggression. His research group also has helped demonstrate the efficacy of cognitive behavior therapy for adolescent depression. Dr. Brent received a NARSAD Distinguished Investigator Award in 2001 for a study of medication-resistant depression in adolescents, and is a recipient of many honors, including membership in the Institute of Medicine of the National Academy of Sciences. He has published nearly 150 papers in professional journals and contributed numerous book chapters. David Shaffer, M.D., is the Philips Professor of Child Psychiatry and professor of psychiatry and pediatrics at Columbia University College of Physicians and Surgeons; attending psychiatrist at Columbia University Medical Center NewYork-Presbyterian Hospital, where he is also director of pediatric psychiatry at Babies Hospital; and director of the division of child psychiatry at the New York State Psychiatric Institute. Originally from South Africa, Dr. Shaffer received a degree in psychological medicine from the University of London. He trained in pediatrics at the Hospital for Sick Children, Great Ormond Street, and trained in psychiatry at the Maudsley Hospital. It was from there, in the 1960s, that he conducted the first epidemiological study of child and early adolescent suicide using the psychological autopsy method. Unexpected at the time, the findings revealed a short delay between experiencing a stressor and the act of suicide, the frequency of aggressive behavior, and the suggestion that imitation played a role in youth suicide. His later work confirmed that most teen suicides occur in the context of a psychiatric illness. His research also highlighted the significance of alcohol and substance abuse and a prior suicide attempt as additional risk factors for older male teens, but not for females, in whom major depression is especially important. In a controlled study of suicide-awareness programs, Dr. Shaffer and his colleagues revealed significant limitations to a purely educational approach to suicide prevention. He set out to develop a strategy and technique for screening teens for the disorders that predispose them to suicide and created the Columbia Teen Screen, which is in use nationwide. Dr. Shaffer has published more than 100 peer-reviewed articles on his work and authored 80 book chapters. He serves on the editorial board of several professional journals and is past president of the American Foundation for Suicide Prevention and of the Society for Research in Child and Adolescent Psychopathology. He received a NARSAD Distinguished Investigator Award in 1992. 17 The Ruane Prize In Memoriam It is with deep sorrow that we report the death of Joy M. Ruane on October 11, 2006. Mrs. Ruane joined with her husband, Bill, in creating and sustaining the Ruane Prize for Outstanding Achievement in Child and Adolescent Psychiatric Research. We mourned Bill Ruane’s loss just a year ago as we mourn Joy’s now. Bill and Joy were a couple with extraordinary philanthropic concerns. Their very strong support for NARSAD through the years had always been based on a request for anonymity. But their conviction of the importance of the search for treatments and cures, and of breakthroughs by great scientists in child and adolescent psychiatry, led them to give their names to this award. NARSAD mourns an extraordinary couple and expresses deep gratitude for their dedication to the lives of others, most especially to the needs and hopes of children and adolescents. The Sidney R. Baer, Jr. Prize for Schizophrenia Research Lorna W. Role, Ph.D. Although Dr. Role is not new to science, she is relatively new to schizophrenia research and is an ideal recipient of the Sidney R. Baer, Jr. Prize. To solve the riddle of schizophrenia, it has been imperative that we recruit top neuroscientists and apply the most powerful research strategies. Dr. Role was in the prime of her career, working on nicotinic neurotransmitters and on neuregulin isoforms, when she was recruited to the Lieber Center for Schizophrenia Research and then received a NARSAD Distinguished Investigator Award. Since that fortuitous start, she has carried out spectacular work on the combined effects of candidate genes on the mechanisms that cause schizophrenia and give rise to its symptoms, and the effects on these of novel therapeutic agents. —- Jeffrey A. Lieberman, M.D., Kolb Professor and Chair of Psychiatry, Columbia University College of Physicians and Surgeons; Lieber Professor and Director, Lieber Center for Schizophrenia Research; Director, New York State Psychiatric Institute 18 Lorna A. Role, Ph.D., is professor of cell biology in the Center for Neurobiology and Behavior at Columbia University College of Physicians ‘and Surgeons, where she has been a member of the faculty for 21 years. Her scientific trajectory has taken her from a bachelor’s degree in mathematics to a Ph.D. in physiology, both earned at Harvard University, to promising research into the mechanisms of the central nervous system. Beginning with studies on the physiology and development of neuronal synapses responsive to nicotine, her research has focused on molecular mechanisms and neural pathways underlying motivation, memory and mood. Over the last decade, in collaboration with Dr. David Talmage, her group identified a novel class of neuregulin-1 isoforms (proteins produced by a candidate gene for schizophrenia), shown to be key regulators of the formation and maintenance of circuits in the central nervous system. A NARSAD Distinguished Investigator Award in 2000 launched Dr. Role’s current investigations of neuregulin gene signaling in schizophrenia. She has published nearly 100 articles in professional journals. Among many other honors, Dr. Role has received a Sloan Scholars Award, Klingenstein Scholars Award, and McKnight Scholars and Development Award in Neuroscience. She has advised and mentored dozens of doctoral and postdoctoral trainees. Report of the Executive Director Success, they say, breeds success. In keeping with NARSAD’s phenomenal growth over the past several years, 2006 was yet another year of exceeding expectations. It is no surprise, therefore, that in 2006, NARSAD was singled out for its organizational integrity as well as for the societal impact of the scientific research that it funds. We can all take pride in these accomplishments. Grant-making is at the heart of NARSAD’s work, and 2006 was by all measures a record-setting year. I am particularly proud of the 206 Young Investigators whose work we were able to fund. These outstanding men and women are the hope for the future of mental health research, and I am certain that we will be hearing about their findings in the years to come, as they build on work begun with NARSAD’s support. This past October, at our annual New York gala, we honored our Scientific Council, which makes NARSAD’s research grants programs possible. In celebrating the 20th anniversary of the Council’s founding, it was so very meaningful to watch as these scientists of high achievement were recognized for their contributions to NARSAD’s development and growth. Likewise our regional dinners and research symposia in 2006 were extraordinary events both in terms of fund-raising and making available to the public sound information about some of the latest developments in research. All these elements came together especially well at our first Boston symposium and dinner, which demonstrated the power of bringing under one roof researchers, donors and potential donors. In the last several years, it has increasingly been our goal to raise public awareness about NARSAD’s vital work. In 2006, we were fortunate to be assisted by celebrity spokespersons. At our annual Palm Beach gala, Anderson Cooper of CNN spoke movingly about his brother who suffered and died from severe mental illness. In just a few short minutes, Anderson was able to express the feelings and aspirations of each person in the room. And, at our inaugural gala in Los Angeles, former first lady Rosalynn Carter helped provide a historical perspective on our quest for better treatments and cures. In doing so, she conveyed what our organization’s work over two decades has been all about. While our regional symposia have become a valuable tool for informing the public, a far greater number of people now have the opportunity to learn about mental illness and the progress being made in research from our website, www.narsad.org, which was re-launched in 2006 after a major redesign. We were also able to reach many more people in 2006 with the debut of the award-winning television series “Healthy Minds,” produced by PBS station WLIW21 in New York with assistance from NARSAD. The program’s 13 episodes can now be viewed in full on our website. As NARSAD’s public profile has steadily risen, it has earned well-deserved plaudits from trusted public entities and institutions. In 2006, the Better Business Bureau Wise Giving Alliance — having completed a comprehensive assessment of NARSAD’s governance, fundraising practices, informational materials and how we spend our money — informed NARSAD that it had met the BBB Standards for Charity Accountability. We are proud of their glowing report and will add it to those of other charity rating services that have evaluated and commended our work. As NARSAD celebrates 20 years of grant-making in 2007, the scope of its operations and their cumulative impact continue to grow. A presidential search has now given us new leadership, and it is with renewed energy and optimism that we approach the next 20 years of fund-raising, grant-making and public education. We remain committed as ever to our mission, fully expecting that success will, indeed, continue to breed success. Stephen G. Doochin NARSAD’s Executive Director 19 Honoring NARSAD Young Investigators The Klerman and Freedman Awards The Klerman and Freedman Awards annually recognize the high achievements of past NARSAD Young Investigators. The Klerman Award, for exceptional clinical research, was established in 1994 by Myrna Weissman, Ph.D., of Columbia University, in memory of her husband, Gerald L. Klerman, M.D. The Freedman Award, which recognizes excellence in basic research, honors the memory of Daniel X. Freedman, M.D., a pioneer in biological psychiatry. In part through these awards, the legacies of Gerald Klerman and Daniel Freedman, in their roles as teachers, physicians and administrators, continue to make an indelible impact upon the field of neuropsychiatry and inspire the careers of neuroscientists of all ages. The Twelfth Annual Klerman Awardee Hilary P. Blumberg, M.D. Yale University School of Medicine Dr. Blumberg Dr. Hilary Blumberg was selected for her groundbreaking work demonstrating hyperactive amygdala function and decreased activity of the area of the brain that regulates amygdala function, the ventral prefrontal cortex (VPFC), as well as the development of these structures and their malfunction in adolescent bipolar disorder patients. Her work has further demonstrated the effect of mood-stabilizing medications (divalproex and lithium) in normalizing the function of the amygdala-VPFC circuit, which raises the possibility that the ability to identify bipolar disorder early in its course may provide the opportunity to improve prognosis by halting the progression of the disorder. — Jan Fawcett, M.D., University of New Mexico; Chair, Klerman Award selection committee 20 Hilary P. Blumberg, M.D., is an associate professor of psychiatry and diagnostic radiology and director of the Mood Disorders Research Program at Yale University School of Medicine and the Department of Veterans Affairs (West Haven campus). She graduated summa cum laude from Harvard University and then completed her medical degree, psychiatry residency training and postdoctoral training in neuroimaging at Cornell University Medical College. The Ninth Annual Freedman Award Michael D. Ehlers, M.D., Ph.D. Howard Hughes Medical Institute and Duke University Dr. Michael D. Ehlers is a world leader in understanding the mechanisms that govern synapse formation and function in the brain. Using both molecular and imaging methods, he has elaborated how the archi tecture of brain cells is organized and maintained, and how the ability of cells to change their structure may be critical to understanding how brain function is altered in neuropsychiatric disorders. Dr. Ehlers — Ariel Y. Deutch, Ph.D., Vanderbilt University; Chair, Freedman Award selection committee Michael D. Ehlers, M.D., Ph.D., is associate professor and Wakeman Scholar in the department of neurobiology at Duke University. He received his B.S. degree in chemistry at the California Institute of Technology before pursuing graduate and medical studies in neuroscience at the Johns Hopkins University. In 2005, he was selected as one of 43 biomedical researchers in the United States to become an investigator of the Howard Hughes Medical Institute. He received NARSAD’s Young Investigator award in 2000 and 2002. NARSAD 2006 Mental Health Research Symposia In 2006, the symposium series entered its eighteenth year. Its ambitious goal is to bring news of the cutting-edge work being performed by NARSAD-supported researchers, and developments and trends in their diverse areas of expertise, to NARSAD’s supporters and members of the general public. Provided free of charge and attended by many hundreds and sometimes over a thousand people, each of these events testifies to the public’s thirst for authoritative information about mental illness. The flagship event of the series, held annually in New York City, extends over two full days; regional symposia are typically half-day events. All events in the series promote scientific literacy and vividly convey the great excitement generated by rapid advances in neuroscientific research. While the broad scope of the past year’s events is indicated in the summaries that follow, full accounts of each symposium are provided throughout the year in NARSAD’s quarterly newsletters, and are available online. NARSAD’s 18th Annual New York Research Symposium New York City October 27-28, 2006 The 18th Annual NARSAD New York Mental Health Research Symposium was held at the Mount Sinai School of Medicine in New York City on October 27th and 28th. At the symposium, 15 NARSAD Young Investigator grantees described their research projects and offered comments on the future direction of their studies. As in past years, presentations were organized by category: Basic Science, Mood Disorders and Schizophrenia. Three members of NARSAD’s Scientific Council provided expert commentary and contextualization of the individual presentations: Peter W. Kalivas, Ph.D., professor and chair of neurosciences at the Medical University of South Carolina (Basic Science); J. John Mann, M.D., Ph.D., professor of psychiatry and translational neuroscience, Columbia University College of Physicians & Surgeons and chief of neuroscience at the New York State Psychiatric Institute (Mood Disorders); and Jeffrey A. Lieberman, M.D., chair of psychiatry at Columbia University College of Physicians & Surgeons and director of the New York State Psychiatric Institute (Schizophrenia). Herbert Pardes, M.D., president and CEO of NewYork-Presbyterian Hospital and president of NARSAD’s Scientific Council, moderated the symposium. Robert M. A. Hirschfeld, M.D., Titus H. Harris Chair and professor of the department of psychiatry and behavioral sciences at the University of Texas Medical Branch in Galveston and member of the NARSAD Scientific Council, selected the 15 researchers who reported at the symposium from a pool of 206 NARSAD Young Investigators for 2006. 21 New York City Symposium Program Session 1: Basic Science Research Commentator: Peter W. Kalivas, Ph.D. Presenters: Mark Ansorge, Ph.D., of Columbia University, spoke about the role of the neurotransmitter serotonin in modulating depressive-like behavior. Selena Bartlett, Ph.D., at the Julio Gallo Clinic and Research Center of the University of California, San Francisco, spoke about dopamine receptor trafficking and its involvement in schizophrenia. Jean-Claude Beique, Ph.D., of Johns Hopkins University, discussed anomalies in synaptic structure and how these may play a role in schizophrenia. Stephanie L. Borgland, Ph.D., at the Ernest and Julio Gallo Clinic and Research Center of the University of California, San Francisco, discussed how orexin, a substance manufactured in the hypothalamus, affects glutamate receptors in the brain, in turn influencing a range of behaviors involved in serious mental illness. Colleen McClung, Ph.D., of the University of Texas Southwestern Medical Center at Dallas, explained the role of genes in the daily circadian rhythm and their role in mood disorders. Session 2: Affective Disorders Research Commentator: John Mann, M.D., Ph.D. Presenters: 22 Robert Berman, M.D., Ph.D., of the New York State Psychiatric Institute, described a new method of brain stimulation called FEAST, used in treating refractory depression. Amanda Guyer, Ph.D., of Columbia University, spoke about new ways of identifying children at risk for bipolar disorder. Steven F. Kendell, Ph.D., of Yale University, explained how riluzole (Rilutek), an atypical antipsychotic medicine, is used to treat resistant depression. Jason Scalia, Ph.D., of Columbia University, explained how SSRI inhibitors, taken by depressed patients, may promote neurogenesis in the hippocampus. Hugh Brent Solvason, M.D., Ph.D., of Stanford University School of Medicine, spoke about managing elevated obesity and diabetes risk in patients being treated for bipolar disorder. Session 3: Schizophrenia Research Commentator: Jeffrey A. Lieberman, M.D. Presenters: Dimitri Avramopoulos, M.D., Ph.D., of the Johns Hopkins University School of Medicine, discussed the genetics of schizophrenia. Stefania Bonaccorso, M.D., Ph.D., of Vanderbilt University, spoke about improving cognition in patients with schizophrenia. Karin E. Borgmann-Winter, M.D., of Children’s Hospital of Philadelphia, discussed a novel method of assessing the transition from latency to disease in schizophrenia, which could lead to new early-intervention strategies. Steven R. Laviolette, Ph.D., of the Schulich School of Medicine at the University of Western Ontario, explained how the cannabinoid system in the brain might be involved in some of the emotional processing deficits commonly observed in schizophrenia. Anita Ramani, Ph.D., of New York University School of Medicine, described use of a new MRI technique called diffusion kurtosis imaging to study brain structure in schizophrenia. NARSAD 2006 Mental Health Research Regional Symposia Sarasota, Florida Ninth Annual Mental Health Research Symposium January 7, 2006 More than 1,100 people attended NARSAD’s ninth annual mental health research symposium in Sarasota, and heard from a panel of four leading researchers. Wade Berrettini, M.D., Ph.D., from the University of Pennsylvania, served as panel moderator and delivered a presentation on nicotine addiction in psychiatric disorders. The other presenters included: A. John Rush, Jr., M.D., professor of psychiatry and vice chairman of research at the University of Texas Southwestern Medical Center at Dallas, who discussed means of achieving better outcomes with depressed patients; Joseph R. Calabrese, M.D., professor of psychiatry at Case Western Reserve University, who provided an update on the management of depression and bipolar disorder; and John P. O'Reardon, M.D., assistant professor of psychiatry at the University of Pennsylvania, who spoke on new approaches to severe mood disorders, specifically, vagus nerve stimulation and transcranial magnetic stimulation. Washington, D.C. Third Annual “Mission Possible” Research Symposium February 26, 2006 Moderated by Thomas Insel, M.D., director of the National Institute of Mental Health (NIMH) and a former member of NARSAD’s Scientific Council; presentations included: Daniel S. Pine, M.D., chief of child and adolescent research in the mood and anxiety disorders program at NIMH, who explained that anxiety disorders in childhood are probably the best predictors of risk for depression over a lifetime; B. Timothy Walsh, M.D., Ruane Professor of Pediatric Psychopharmacology at the College of Physicians and Surgeons of Columbia University and founder of the Eating Disorders Research Unit at New York State Psychiatric Institute, who addressed the subject of eating disorders; David J. Posey, M.D., M.S., associate professor of psychiatry and chief of the Christian Sarkine Autism Treatment Center at the Indiana University School of Medicine, discussed efforts to develop medications to treat autism; and Ellen Leibenluft, M.D., chief of the unit on affective disorders of the pediatrics and developmental neuropsychiatry branch in the NIMH mood and anxiety program, who discussed childhood bipolar disorder. 23 NARSAD 2006 Mental Health Research Regional Symposia Palm Beach, Florida Third Annual “Sunshine from Darkness” Research Symposium March 11, 2006 Wade Berrettini, M.D., Ph.D., of the University of Pennsylvania, moderated the panel and made a presentation about his study of nicotine dependence in people with psychiatric illnesses; Joseph R. Calabrese, M.D., of Case Western Reserve University, talked about developments in the diagnosis and treatment of bipolar disorder; John P. O’Reardon, M.D., of the University of Pennsylvania, described research on new therapies for treatment-resistant depression; and A. John Rush, Jr., M.D., of the University of Texas Southwestern Medical Center at Dallas, discussed new approaches for treating depression. 24 St. Louis, Missouri In conjunction with The Sidney R. Baer, Jr. Foundation Third Annual St. Louis Research Symposium April 1, 2006 Moderated by Herbert Y. Meltzer, M.D., Bixler/May/ Johnson Professor of Psychiatry, professor of pharmacology and director of the Psychobiology Program for Translational Research at Vanderbilt University School of Medicine, in Nashville, Tennessee; presentations included: Amelia Gallitano-Mendel, M.D., Ph.D., instructor of psychiatry at Washington University School of Medicine, who discussed her research on a family of genes called immediate early genes (IEGs), which are activated at high levels in the brain in response to changes in the environment, and whose function may help her team elucidate biological pathways disrupted in schizophrenia; John W. Newcomer, M.D., professor of psychiatry and medicine at Washington University School of Medicine, who spoke about mental disorders, metabolic disturbances and cardiovascular risk; Joan L. Luby, M.D., associate professor of child psychiatry at Washington University School of Medicine, who discussed depression in preschool-age children and on the implications for early intervention and long-term outcome; and Yvette I. Sheline, M.D., professor of psychiatry, radiology and neurology at Washington University School of Medicine, who discussed anhedonia, a core symptom of major depressive disorder characterized by markedly diminished interest or pleasure in most activities. Boston, Massachusetts In conjunction with The Sidney R. Baer, Jr. Foundation First Annual Boston Mental Health Research Symposium April 30, 2006 Moderated by Francine M. Benes, M.D., Ph.D., president and psychiatrist-in-chief of McLean Hospital, who serves as chair of Partners Psychiatry and Mental Health and a professor of psychiatry at Harvard Medical School. Presentations were made by: Jonathan Picker, M.D., Ph.D., attending physician in clinical genetics at Children’s Hospital Boston, who discussed prenatal development and schizophrenia; Maurizio Fava, M.D., professor of psychiatry at Harvard Medical School and director of Massachusetts General Hospital’s Depression Clinical and Research Program, who reviewed lessons learned from the NIMH’s STAR*D study, which has tracked 2,876 “real world” patients suffering from depression; Gina R. Kuperberg, M.D., Ph.D., associate professor of psychology at Tufts University and a psychiatrist at Massachusetts General Hospital, who spoke of her research on spatiotemporal imaging of thought in schizophrenia; and Christopher A. Walsh, M.D., Ph.D., chief of the division of genetics at Children’s Hospital Boston and chief of neurogenetics in the department of neurology at Howard Hughes Medical Institute/Beth Israel Deaconess Medical Center, who discussed his lab’s efforts to identify recessive genes associated with brain malformations that may be linked with susceptibility for schizophrenia. Los Angeles, California Inaugural “Campaign for the Brain” Weekend June 24-25, 2006 Moderators included Lewis Baxter, M.D., professor of psychiatry and neuroscience at the University of Florida, and Kay Redfield Jamison, Ph.D., professor of psychiatry at the Johns Hopkins School of Medicine, with presenations by: Tyrone D. Cannon, Ph.D., Staglin Family Professor of Psychology, Psychiatry and Biobehavioral Sciences and director of the Center for Cognitive Neuroscience at the University of California, Los Angeles, who spoke on vulnerability to major psychoses; David L. Braff, M.D., professor of psychiatry and director of the schizophrenia program at the University of California, San Diego, School of Medicine, who addressed advances in schizophrenia research and treatment; Mark A. Frye, M.D., associate professor of psychiatry (in residence), director of the Bipolar Research Program and associate director of the Mood Disorders Research Program at the Geffen School of Medicine, at the University of California, Los Angeles, who provided an update of treatments for bipolar disorder; and Vivien Burt, M.D., Ph.D., professor of psychiatry at Geffen School of Medicine at the University of California, Los Angeles, and founder and director of the Women’s Life Center of the Semel Institute for Neuroscience and Human Behavior, who discussed postpartum psychoses and depression. 25 NARSAD Events Community Outreach NARSAD Community Meetings Tenafly, New Jersey — March 23, 2006 NARSAD National Leadership Council member Dr. Arthur Peck hosted a community meeting in his home with guest speaker Herbert Lachman, M.D., of Albert Einstein College of Medicine. Dr. Lachman presented an update on new findings related to the identification of the genes underlying schizophrenia and bipolar disorder. Brooklyn Heights, New York — May 11, 2006 Hosted by longtime NARSAD supporters and National Leadership Council members Miriam Katowitz and Arthur Radin; guest speaker: Antigona Martinez, Ph.D., of the Nathan Kline Institute for Psychiatric Research (New York State Office of Mental Health). Dr. Martinez explained how state-of-the-art brain imaging techniques are being used to investigate basic abnormalities of brain functioning in schizophrenia. The 14th Annual Michigan NARSAD Golf Classic Mount Clemens, Michigan — June 19, 2006 Held at the Gowanie Golf Club in Mount Clemens, this annual event is organized by NARSAD National Leadership Council member Peppino Puleo. Always a great day and a tremendous success, The Michigan NARSAD Golf Classic has raised more than $250,000 for mental health research. 26 The 10th Annual John & Kevin Kennedy Memorial Soccer Tournament West Babylon, New York — August 19 and 20, 2006 Sponsored by Lindenhurst Sport Club. Proceeds to NARSAD. First Annual Knights for NARSAD Music Festival Pequannock, New Jersey — August 26, 2006 Presented by the Knights of Columbus Council 5943 — a great day of musical entertainment and fun for the entire family. Michigan Marathon for NARSAD Detroit, Michigan — October 2006 Tom Coles, M.D., a member of NARSAD’s National Leadership Council and former board member, completed his 11th marathon in Michigan in October, running to raise funds for NARSAD. NARSAD Seminar: Recent Progress in Autism Research Great Neck, New York — November 14, 2006 NARSAD and the Great Neck Special Education Parent-Teacher Association co-hosted a special seminar on autism at a local middle school. The guest speaker for the evening was Adriana Di Martino, M.D., of the Institute for Pediatric Neuroscience at New York University’s Child Study Center, who gave a presentation on autism and discussed her recent brain imaging studies, which compare social cognition in typically developing children versus those with autism. Depression Awareness Fundraiser North Woodbridge, New Jersey — December 17, 2006 An evening of dinner and dancing, organized in memory of Nilda Sanchez, featured a special performance by the salsa dance group, Clasico Dancers. 2006 N A R S A D Research Partners Program The NARSAD Research Partners Program unites donors and scientists, who give to each other the benefit of their separate and intense motivation to find better treatments and cures for brain disorders. In this program, donors select a recipient of a NARSAD grant and, in turn, have the grant named in their honor. The donors’ involvement continues beyond this initial stage, as they receive research progress reports from the recipients of their grants, and receive honorary mention in all published work resulting from the research they helped to fund. NARSAD is fortunate to have donors with intense interest in funding research in specific areas within its overall research strategies, and is deeply grateful to all Research Partners for their critical support of dedicated scientists and their vital projects. Research Partner Grants Distinguished Investigators Sidney R. Baer, Jr. Investigator Jerrold P. Rosenbaum, M.D. Donor: Sidney R. Baer, Jr. Foundation Harvard University Essel Investigator Aaron T. Beck, M.D. Donor: The Essel Foundation University of Pennsylvania Harold A. Sackeim, Ph.D. Columbia University Fairfax Foundation Investigator John H. Krystal, M.D. Donor: Fairfax Foundation Yale University Lieber Investigators Robert R. Freedman, M.D. Donor: Constance and Stephen Lieber University of Colorado at Denver and Health Sciences Center Mary-Claire King, Ph.D. University of Washington Nancy S. Wexler, Ph.D. Columbia University Ritter Foundation Investigator Tyrone D. Cannon, Ph.D. Donor: Ritter Foundation University of California, Los Angeles 27 Research Partner Grants Independent Investigators Attias Investigator Hilary P. Blumberg, M.D. Donor: The Attias Family Foundation Yale University Sidney R. Baer, Jr. Investigator Pamela Sklar, M.D., Ph.D. Donor: Sidney R. Baer, Jr. Foundation Harvard University Essel Investigators Rene Anand, Ph.D. Donor: The Essel Foundation Ohio State University Sabine Bahn, M.D., Ph.D., M.R.C. Psych. University of Cambridge Ilana Kremer, M.D. Technion-Israel Institute of Technology Anne B. Sereno, Ph.D. University of Texas Health Science Center at Houston Hofmann Trust Investigators Daniel Levesque, Ph.D. Donor: Hofmann Trust University of Montreal Paul J. Moberg, Ph.D., ABPP University of Pennsylvania Medical School 28 Dr. Walter F. Nichols Investigator Sam Thiagalingam, Ph.D. Donor: Eleanor N. Jernigan Endowment Boston University Nellie Blumenthal Investigators Faith B. Dickerson, Ph.D., M.P.H. Donor: Katz Family Foundation University of Maryland Mary Phillips, M.D. University of Pittsburgh Lattner Foundation Investigator Steven E. Arnold, M.D. Donor: Lattner Foundation University of Pennsylvania Lieber Investigators Deanna M. Barch, Ph.D. Donor: Constance and Stephen Lieber Washington University School of Medicine Todd S. Braver, Ph.D. Washington University Tony P. George, M.D., FRCPC Yale University David J. Posey, M.D. Indiana University Maltz Family Investigators Noboru Hiroi, Ph.D. Donor: Maltz Family Foundation Albert Einstein College of Medicine of Yeshiva University Paul A. Slesinger, Ph.D. Salk Institute for Biological Studies Guochuan Emil Tsai, M.D., Ph.D. University of California, Los Angeles Xia Zhang, M.D., Ph.D. University of Ottawa Research Partner Grants Independent Investigators Nicholson Foundation Investigators Pierre J. Blanchet, M.D., Ph.D. Donor: Nicholson Foundation University of Montreal Fang Liu, M.D., Ph.D. University of Toronto William & Gloria Paul Family Foundation Investigator Dan Rujescu, M.D. Donor: William & Gloria Paul Family Foundation University of Munich Southwest Florida Investigators Jeffrey D. Erickson, Ph.D. Donor: Sunshine from Darkness Gala Lee and Bob Peterson Louisiana State University Rima F. Kaddurah-Daouk, Ph.D. Duke University William and Henry Test Investigator Wendy R. Kates, Ph.D. Donor: The Test Endowment State University of New York, Upstate Medical University Toulmin Investigators Howard Gershenfeld, M.D., Ph.D. Donor: Virginia Toulmin University of Texas Southwestern Medical Center at Dallas Karen E. Stevens, Ph.D. University of Colorado at Denver and Health Sciences Center van Ameringen Investigators William A. Carlezon, Jr., Ph.D. Donor: The van Ameringen Foundation Harvard University Joseph F. Cubells, M.D., Ph.D. Emory University School of Medicine Research Partner Grants Young Investigators Anonymous Robert M. Berman, M.D., Ph.D. Columbia University Peter Bulow, M.D. Columbia University Akira Kugaya, Ph.D. Yale University Atherton Investigator Naama Barnea-Goraly, M.D. Donor: Robert, Martha and John Atherton Foundation Stanford University Sidney R. Baer, Jr. Investigators Selena E. Bartlett, Ph.D. Donor: Sidney R. Baer, Jr. Foundation University of California, San Francisco Joshua W. Brown, Ph.D. Indiana University Miles G. Cunningham, M.D., Ph.D. Harvard University Peter A. Fahnestock, M.D. Washington University 29 Research Partner Grants Young Investigators Sidney R. Baer, Jr. Investigators (continued) Amelia Gallitano-Mendel, M.D., Ph.D. Washington University Takanori Hashimoto, M.D., Ph.D. University of Pittsburgh Daphne J. Holt, M.D., Ph.D. Harvard University Christine Hooker, Ph.D. University of California, Berkeley Dan V. Iosifescu, M.D. Harvard University Jang Woo Kim, M.D. Harvard University Roy H. Perlis, M.D. Harvard University Tracey Petryshen, Ph.D. Harvard University Shaun Matthew Purcell, Ph.D. Harvard University 30 Tatiana Sitnikova, Ph.D. Harvard University Steve Stufflebeam, M.D. Harvard University Daniel H. Wolf, M.D., Ph.D. University of Pennsylvania Foster Bam Investigators Matthew M. Kurtz, Ph.D. Donor: Foster Bam Yale School of Medicine Nenad Sestan, M.D., Ph.D. Yale University Brian Bass Investigator Arielle D. Stanford, M.D. Donor: Barbara and Michael Bass Columbia University Effie D. Beeman Investigator Yuejin Chen, M.D., Ph.D. Donor: Effie Beeman Vanderbilt University Blowitz-Ridgeway Investigators Koraly Perez-Edgar, Ph.D. Donor: Blowitz-Ridgeway Foundation George Mason University Tonya Jo White, M.D. University of Minnesota Bowman Family Investigators Bettina Bankier, M.D. Donor: Bowman Family Foundation Harvard University Lynn L. Johnson, Pharm.D. University of Colorado at Denver and Health Sciences Center Boaz Levy, Ph.D. Harvard University Research Partner Grants Young Investigators Bowman Family Investigators (contined) Michael J. Ostacher, M.D., MPH Harvard University Kristi A. Sacco, Psy.D. Yale University Burdge Family Trust Investigator Beth E. Snitz, Ph.D. Donor: Burdge Charitable Trust University of Pittsburgh Elizabeth Elser Doolittle Investigator Jubao Duan, Ph.D. Donor: Elizabeth Elser Doolittle Charitable Trusts Northwestern University Essel Investigators Stephanie L. Borgland, Ph.D. Donor: The Essel Foundation University of California, San Francisco Wei-Yang Lu, M.D., Ph.D. University of Toronto Chiara Nosarti, MSc., Ph.D. Institute of Psychiatry/King's College London Timothea Toulopoulou, Ph.D., M.Sc., B.A. Institute of Psychiatry/King's College London Chong-Bin Zhu, Ph.D. Vanderbilt University Freer Family Investigator Gregor E. Berger, M.D. Donor: The Freer Family University of Melbourne Rollin M. Gerstacker Investigator Jonathan Metzl, M.D., Ph.D. Donor: Rollin M. Gerstacker Foundation University of Michigan Medical Center Alice & Walter Happ Investigators Katherine Burdick, Ph.D. Donor: Estate of Alice K. Happ Albert Einstein College of Medicine of Yeshiva University Tamim Shaikh, Ph.D. University of Pennsylvania International Partnership for Mental Health Research Investigator Ofer Agid, M.D. University of Toronto Donor: International Partnership for Mental Health Research Marcia Simon Kaplan Investigator Jessica H. Kalmar, Ph.D. Donor: Marcia Simon Kaplan Yale University Katowitz/Radin Investigators Antigona Martinez, Ph.D. Donor: Miriam Katowitz and Arthur Radin New York University Lee Zuckerman, Ph.D. Columbia University Lieber Investigators Stefania Bonaccorso, M.D. Donor: Constance and Stephen Lieber Vanderbilt University Darlene H. Brunzell, Ph.D. Yale University Eiji Hattori, M.D. RIKEN Brain Science Institute 31 Research Partner Grants Young Investigators Lieber Investigators (continued) Hiroko Koike, M.D., Ph.D. Columbia University Giamal N. Luheshi, Ph.D. McGill University Ganeshwaran H. Mochida, M.D., M.M.Sc. Harvard University Roel A. Ophoff, Ph.D. Utrecht University Narsimha Reddy Pinninti, MBBS, M.D., DPM University of Medicine & Dentistry of New Jersey Helen B. Simpson, M.D., Ph.D. Columbia University Takuya Takahashi, M.D., Ph.D. Cold Spring Harbor Laboratory Jacob A.S. Vorstman, M.D. Utrecht University 32 Harold I. & Faye B. Liss Foundation Investigator Edgar A. Buttner, M.D., Ph.D. Donor: Harold I. & Faye B. Liss Foundation Harvard University Marshall-Reynolds Foundation Investigator Falk W. Lohoff, M.D. Donor: Marshall-Reynolds Foundation University of Pennsylvania NARSAD Artworks Investigator Andrea Faedo, Ph.D. Donor: NARSAD Artworks University of California, San Francisco Daniel X. Freedman Investigator Weidong Li, M.D., Ph.D. Donor: NARSAD Research Fund University of California, Los Angeles Domenici Investigator Brett Y. Lu, M.D., Ph.D. Donor: NARSAD Research Fund University of New Mexico Gwill Newman Investigator Maria Cecilia Angulo, Ph.D. Donor: NARSAD Research Fund Université René Descarte NAMI of Michigan Investigator Simon J. Evans, Ph.D. Donor: National Alliance for the Mentally Ill of Michigan University of Michigan Medical Center Oxley Investigators Naomi Eisenberger, Ph.D. Donor: The Oxley Foundation University of California, Los Angeles Syed Naqvi, M.D. University of California, Los Angeles Prechter Investigator Sandra Villafuerte, Ph.D. Donor: World Heritage Foundation (Waltraud Prechter) University of Michigan Medical Center Sallie Foundation Investigator Julie Linker, Ph.D. Donor: The Sallie Foundation Virginia Commonwealth University Seaver Investigator Evdokia Anagnostou, M.D. Donor: The Beatrice & Samuel A. Seaver Foundation Mount Sinai School of Medicine Research Partner Grants Young Investigators Mogens Schou Investigator Alexander B. Niculescu, M.D., Ph.D. Donor: Marylou Selo Indiana University Stone Investigator Serge A. Mitelman, M.D. Donor: Jean and Donald Stone Mount Sinai School of Medicine Southwest Florida Investigators Martin Beaulieu, Ph.D. Donor: Sunshine from Darkness Gala, Lee and Bob Peterson Duke University Jean-Claude Beique, Ph.D. Johns Hopkins University Xinzhong Dong, Ph.D. Johns Hopkins University Thomas M. Maynard, Ph.D. University of North Carolina-Chapel Hill Jill A. Morris, Ph.D. Northwestern University Karl D. Murray, Ph.D. University of California, Davis Karen K. Szumlinski, Ph.D. University of California, Santa Barbara William and Henry Test Investigator R. Jeroen Pasterkamp, Ph.D. Donor: The Test Endowment Utrecht University Wodecroft Foundation Investigators Anirban Basu, Ph.D. Donor: Wodecroft Foundation University of Chicago Dwight E. Bergles, Ph.D. Johns Hopkins University Karin Borgmann-Winter, M.D. University of Pennsylvania Yuncai Chen, Ph.D. University of California, Irvine Branislav Mancevski, M.D. Columbia University Lori Montross, Ph.D. University of California, San Diego Steffen Moritz, Ph.D. University of Hamburg Jeremy Amiel Rosenkranz, Ph.D. University of Texas at Austin Naoya Sawamura, Ph.D. Waseda University 33 Accelerating Discovery 2006 Grant Programs NARSAD’s annual grant-making process is characterized by painstaking scientific review and dedicated administrative follow-through. The objective is to make certain that the most promising psychiatric research is supported. Each year, NARSAD invites scientists from all over the world, at all career stages, to submit grant applications for review. 34 Members of NARSAD’s Scientific Council donate time and talent to a careful and thorough review of each of the 1,000-plus grant proposals received each year. The Council, in turn, recommends the most meritorious applications to the Board of Directors, which has the responsibility for approving them. The return on NARSAD’s cumulative investment — which in 2006 neared the $200-million mark — has been enormous. NARSAD support has allowed scientists to publish important findings in the most prestigious medical and scientific journals, where their results are shared with other researchers, clinicians and the public. NARSAD support also allows scientists with new ideas to change research direction, something that is normally quite difficult for established researchers to do. Supported scientists are then able to collect enough preliminary data to obtain subsequent funding for larger studies that build on the results of NARSAD-supported work. 2006 NARSAD Grants — An Overview In 2006, a record number of new grants were made, totaling approximately $19 million. Brief summaries of the three major grant programs follows: “an exceptional group of scientists…who have become extraordinarily prestigious in the fields related to understanding and treating mental illness.” Dr. Barchas points out that the NARSAD Distinguished Investigator Award is more difficult to obtain than a grant from the National Institutes of Health. Applicants in 2006 not surprisingly represented all areas of first-rate research in mental illness, from genetics, imaging, neurobiology and psychology, to applied and translational research. Dr. Barchas summarized the grant-making process for 2006: “As much as possible, the final selection of awardees reflects a balance among areas of research and scholars of diverse orientations. A striking aspect of this year’s competition is the degree to which genetics has come to involve multiple areas of investigation, from cell biology to behavior. Also remarkable is the excellence of the proposals not only from researchers in such traditional fields as psychiatry and psychology, but also from highly accomplished investigators in other fields who now want to apply their knowledge and skills toward the enormous problems of severe mental illness. “In an era of tight constraints in the federal government’s funding of new research at the seed-funding stage, NARSAD’s Distinguished Investigator awards are more critical than ever for the excellence and vitality of research on mental illness.” 46 Independent Investigator Awards 20 Distinguished Investigator Awards The Distinguished Investigator program, launched in 1988, is highly selective, seeking to fund urgent research by experienced and highly accomplished scientists from leading institutions. The program offers one-year grants of up to $100,000, and fills an increasingly important niche in mental-health grantgiving. Jack D. Barchas, M.D., chair of the department of psychiatry at Weill Medical College of Cornell University and long-time Scientific Council member, headed the committee that selected the 2006 Distinguished Investigators. In his words, they are NARSAD’s Independent Investigator Award program provides support for scientists during the critical period between the initiation of their research careers and the securing of sustained funding. The award is designed for scientists at the associate professor level or equivalent who are clearly independent and have won national competitive support as principal investigators. The 2006 Independent Investigators will receive up to $100,000 over two years in support of their research programs, which encompass clinical and basic research of major brain and behavior disorders, post-traumatic stress disorder, autism, and attention-deficit hyperactivity disorder (ADHD). The grantees were selected by a committee headed by Robert M. Post, M.D., of NARSAD’s Scientific Council. The far-ranging studies by the 2006 Independent Investigators will look at such important and compelling subjects as the role of stress in the development of mental illness; the effectiveness and action of drugs for various disorders; changes in brain structure of people with different types of depression; genetic susceptibility for depression, bipolar disorder and schizophrenia; biomarkers for mood disorders; suicidal tendencies in people with bipolar disorder; and possible drug treatments for autism. 206 Young Investigator Awards A record number of Young Investigators were chosen in 2006 from an applicant pool that numbered over 800. Each grant recipient will receive $30,000 a year, for one or two years, in support of research being conducted at more than 80 universities and research centers in the U.S., Canada, Europe, Australia, and Israel. The selection committee was chaired by Dr. Herbert Y. Meltzer, Bixler/May/Johnson Professor of Psychiatry and professor of pharmacology at Vanderbilt University Medical Center and a longtime Scientific Council member. “While our mission is still mainly focused on schizophrenia and depression, it has broadened to encompass outstanding research across the spectrum of brain and behavior disorders, and these are reflected in the new grants,” Dr. Meltzer said. These disorders include autism, Alzheimer’s disease, anxiety disorders, post-traumatic stress disorder, addiction, obsessive-compulsive disorder, Tourette syndrome and eating disorders. Dr. Meltzer also reported a welcome increase in the number and quality of clinical studies. In addition, he said, “NARSAD makes a point of supporting areas often neglected by other funders, such as psychosocial research.” Young Investigators reflect current research trends made possible by innovative technological and computational advances, particularly in brain imaging and genetics. These, in turn, are fueling a rapid upsurge in what is called translational research, through which basic discoveries are turned into new or improved therapies. Among powerful new technologies, functional magnetic resonance imaging (fMRI) provides a noninvasive view of blood-flow patterns indicating brain areas in action; and magnetic resonance spectroscopy (MRS) makes it possible to measure chemical activity in the brain. Many of the Young Investigators will study the cells, proteins, and pathways involved in neural development and function and the physiological bases for the aberrant behaviors of psychiatric disorders. Some studies are aimed at better, faster-acting drugs; others are developing and testing nonpharmacological interventions like cognitive therapy and brain stimulation. Studies are underway to help patients cope better with their illnesses and to comply better with treatment regimens. In addition to isolating and testing a range of new molecular targets for drugs, 2006 Young Investigators are also seeking to explain how existing drugs work. 35 The Staglin Family Music Festival Award for Schizophrenia Research The NARSAD Staglin Award is annually earmarked for a single early-career scientist whose research is uncovering the causes of schizophrenia and leading to improved treatments. The $250,000 grant, over three years, is donated to NARSAD by The Eva S. Anton, Ph.D. Staglin Family Music Festival for Mental Health, hosted by Shari and Garen Staglin at their Napa Valley vineyard to raise funds for mental health research. The 2006 Staglin Family Music Festival for Mental Health awardee was Eva S. Anton, Ph.D., an associate professor at the University of North Carolina School of Medicine and a 2005 NARSAD Young Investigator. Dr. Anton is studying neuregulin-1 (NRG1), one of the genes whose variants have been strongly linked with the development of schizophrenia. His research promises to shed light on how NRG1, with its influence over the growth, placement, and function of neurons in the developing brain, could lead to defects in neural circuitry. 2006 NARSAD Grants Distinguished Investigators Lori Altshuler, M.D. John H. Krystal, M.D. University of California, Los Angeles “Etiology of Orbitofrontal Dysfunction in Bipolar Disorder” Yale University “GABRA2 Contributions to NMDA Receptor Deficient-Related Prefrontal Dysfunction” Susan G. Amara, Ph.D. University of Pittsburgh “Zebrafish as a Vertebrate Model System for Examining the Genetics of Antidepressant Action” Aaron T. Beck, M.D. University of Pennsylvania “Cognitive Behavioral Therapy for Negative Symptoms of Schizophrenia: A Pilot Study” Xandra O. Breakefield, Ph.D. Harvard University “Live Cell Imaging of Synaptic Dynamics” Maja Bucan, Ph.D. University of Pennsylvania “Identification and Characterization of Conserved Non-Coding and/or Regulatory Elements in Schizophrenia Candidate Regions” Tyrone D. Cannon, Ph.D. 36 University of California, Los Angeles “A Translational Genetics Approach to Schizophrenia and Bipolar Disorder” Robert R. Freedman, M.D. University of Colorado at Denver and Health Sciences Center “Development of Nicotinic Receptor Agonist Therapy for Schizophrenia” Paul J. Lombroso, M.D. Yale University “Regulation of MAP Kinase by the Striatal Enriched Protein Tyrosine Phosphatase (STEP)” John S. March, M.D., M.P.H. Duke University “Pharmacogenomic Approach to Severe SSRI-Induced Adverse Drug Reactions in Youth” Angus C. Nairn, Ph.D. Yale University “Neuroproteomic Analysis of the Actions of BDNF and Other Neurotrophic Factors” John C. Roder, Ph.D. University of Toronto “Validation of DISC-1 as a Schizophrenia Gene” Jerrold P. Rosenbaum, M.D. Harvard University “Magnetic Resonance Spectroscopic Imaging of Children at Risk for Anxiety and Depression” Harold A. Sackeim, Ph.D. Columbia University “Development of a Novel Focal Europharmacotherapy (FEAT)” Elliot S. Gershon, M.D. C. Dominique Toran-Allerand, M.D. University of Chicago “Genomic Imbalances in Bipolar Disorder and Schizophrenia” Columbia University “17a-estradiol, Neurogenesis and Disorders of Mood” Elizabeth Gould, Ph.D. Nancy S. Wexler, Ph.D. Princeton University “Parenting, Social Stress and Neural Plasticity in Primates: Possible Models of Anxiety and Depression” Columbia University “Genome Scan for Genes Predisposing to Schizophrenia and Affective Disorder in the Venezuelan Huntington's Disease Kindred” Mary-Claire King, Ph.D. Marina Wolf, Ph.D. University of Washington “A Genomic Approach to Gene Discovery in Schizophrenia” The Chicago Medical School “Receptor Trafficking in Animal Models of Psychiatric Disorders” 2006 NARSAD Grants Independent Investigators Steven E. Arnold, M.D. Marco Battaglia, M.D. University of Pennsylvania “Chronic Stress Effects in ‘Sandy’, a Genetic Mouse Model of Schizophrenia: Behavior and Molecular Neuroanatomy” San Raffaele Vita--Salute University “A fMRI and Genetic Study of Cerebral Responses to Socialemotional Stimuli in Children Followed-up for Social Shyness” Deanna M. Barch, Ph.D. Pierre J. Blanchet, M.D., Ph.D. Washington University “The Development Neurobiology of Working Memory Deficits as a Risk Factor for Schizophrenia” University of Montreal “Randomized, Double-blind, Placebo-controlled Pilot Trial on the Efficacy of Docosahexaenoic Acid on Tardive Dyskinesia” 2006 NARSAD Grants Independent Investigators Hilary P. Blumberg, M.D. Shaul Hestrin, Ph.D. Yale University “Frontal Markers of Vulnerability and Resilience to Bipolar Disorder” Stanford University “Cannabinoids and Inhibitory Networks in the Neocortex” Vadim Bolshakov, Ph.D. Noboru Hiroi, Ph.D. Harvard University “Synaptic Plasticity in the Amygdala Underlying Extinction of Conditioned Fear” Albert Einstein College of Medicine “A Human 22q11.2 Segment and Endophenotypes of Schizophrenia in Mice” Linda Carpenter, M.D. L. Fredrik Jarskog, M.D. Brown University “Do Emotional and Biological Responses to a Laboratory Stress Test Predict Risk for Depressive and Anxiety Disorders?” University of North Carolina-Chapel Hill “Longitudinal Effects of Typical and Atypical Antipsychotics on Rat Brain Structure by High Resolution MRI” Pablo E. Castillo, M.D., Ph.D. Wouter Koek, Ph.D. Albert Einstein College of Medicine “Endocannabinoid-Signaling in Schizophrenia” University of Texas Health Science Center at San Antonio “Early-Life Stress, Genetic Vulnerability, and Affective Disorders” Hagit Cohen, Ph.D. Ben Gurion University “Stressful Experiences in Early-Life as a Potential Risk Factor for Altered Stress Responsivity in Adulthood Phenotypic, Endphenotypic and Environmental Influences in an Animal Model” Melissa P. DelBello, M.D. University of Cincinnati “Identifying Biomarkers of Abnormal Metabolism in Adolescents with Bipolar Disorder Using Proton and Phosphorus Magnetic Resonance Spectroscopies” Kim Q. Do, Ph.D., Privat-Docent University of Lausanne “Glutathione/Redox Dysregulation in First Psychotic Episode Patients: Towards a Biomarker Profile for Early Intervention” Douglas C. Eikenburg, Ph.D. University of Houston “Regulation of Neuronal GRK3 Expression: A Critical Modulator of Signaling in Bipolar Disorder” Grigori Enikolopov, Ph.D. Cold Spring Harbor Laboratory “Neural Stem and Progenitor Cell Targets of Antidepressant Therapies” Brian A. Fallon, M.D., M.P.H. Columbia University ”IV Ceftriaxone for Refractory Psychosis Submission” Ruth Feldman, Ph.D. Bar-Ilan University “Effects of Maternal Depression and Genetic Disposition on the Development of PTSD in Infants and Young Children Exposed to War, Terror, and Violence” Mark A. Frye, M.D. Mayo Clinic, Minnesota “High-Field Proton MRS of Anterior Cingulate in Bipolar vs. Unipolar and Melancholic vs. Atypical Depression” Uriel Heresco-Levy, M.D. Hebrew University “N-methyl-D-aspartate Receptor (NMDAR)-Based Pharmacotherapy with D-cycloserine for Treatment-Resistant Major Depressive Disorder” Christian G. Kohler, M.D. University of Pennsylvania “Emotion Recognition and Expression in Stable Schizophrenia” Tao Li, M.D., Ph.D. University of London “Exploring Influence of Genetic Variation on the Cognitive Deficits Underlying Schizophrenia” Xiaohua Li, M.D., Ph.D. University of Alabama at Birmingham “Clinical Implication of Glycogen Synthase Kinase-3 in Mood Disorders” Fang Liu, M.D., Ph.D. University of Toronto “A Protein-Protein Interaction in Hyper-Dopaminergia: In Search of a Novel Therapeutic Target for Antipsychotics” In Kyoon Lyoo, M.D., Ph.D. Seoul National University Hospital “Amygdala Shape Alteration in Posttraumatic Stress Disorder (PTSD): A Longitudinal Follow-Up Study” Anil K. Malhotra, M.D. Albert Einstein College of Medicine “Genetics of White Matter Integrity in Schizophrenia” Dara S. Manoach, Ph.D. Harvard University “Spatiotemporal Dynamics of Intact and Impaired Executive Functions in Schizophrenia: Task Preparation, Performance Evaluation, and Remedial Performance Adjustment” Lauren B. Marangell, M.D. Baylor College of Medicine “Achieving a Better Understanding of Suicidality in a Generalizable Cohort of Patients with Bipolar Disorder” Kenneth E. McCarson, Ph.D. University of Kansas “Chronic Pain Activates Mechanisms of Depression” Francis J. McMahon, M.D. National Institute of Mental Health “Genetic Determinants of Outcome and Side Effects of Antidepressant Treatment” 37 2006 NARSAD Grants Independent Investigators Venkatesh N. Murthy, Ph.D. Stephen R Salton, M.D., Ph.D. Harvard University “Synaptic Function and Plasticity in Two Mouse Models of Schizophrenia” Mount Sinai School of Medicine “Role of the BDNF-inducible Gene VGF in Depression and Antidepressant Responses” Ziad Nahas, M.D. Wei-Xing Shi, Ph.D. Medical University of South Carolina “A Pilot Safety and Efficacy Study of Chronic Epidural Prefrontal Cortical Stimulation (EpCS) in Severe Treatment-Resistant Unipolar Depression” Yale University “Prefrontal Control of Dopamine Neurons in the Ventral Tegmental Area” David J. Posey, M.D. Harvard University “Whole Genome Association Scan of Bipolar Disorder” Indiana University “Memantine in Autism: A Placebo-Controlled Trial of Combined Pharmacotherapy” Michael Poulter, Ph.D. Robarts Research Institute “Dysregulation of GABA-A Receptor Gene Expression in Depression/Suicide” Henriette Raventos, M.D., M. Sc. Universidad de Costa Rica “Phenotypic Characterization of a Neuregulin-1 Missense Mutation Associated with Psychosis in Costa Rica” 38 Dan Rujescu, M.D. Pamela Sklar, M.D., Ph.D. Paul A. Slesinger, Ph.D. Salk Institute for Biological Studies “Role of SNX27 in Regulation of G Protein Signaling in the Brain” Jeffrey A. Stanley, Ph.D. Wayne State University “Assessing Membrane Precursor Levels in Pediatric ADHD: A Whole-Brain, Multi-Voxel 31P Spectroscopy Study at 4 Tesla” Sam Thiagalingam, Ph.D. Boston University “Epigenetic Modulation of Serotonin Signaling in the Pathogenesis of Schizophrenia” University of Munich “Identification of Novel Schizophrenia Genes” Guochuan Emil Tsai, M.D., Ph.D. Ronald M. Salomon, M.D. University of California, Los Angeles “Evaluating Sarcosine, a Glycine Uptake Inhibitor, for Cognition Enhancement in Schizophrenia” Vanderbilt University “MRI BOLD Imaging of Interregional Variability in Depression: Sensitivity to Effects of Acute Tryptophan Depletion” Xia Zhang, M.D., Ph.D. University of Ottawa “Role of Cytoplasmic Polyadenylation Element Binding Protein (CPEB)” 2006 NARSAD Second-Year Grants Independent Investigators Michael Hall Allen, M.D. Sofia Avissar, Ph.D. University of Colorado at Denver and Health Sciences Center “Effects of Nicotine Replacement Therapy on Agitation and Aggression in Schizophrenic Smokers” Ben Gurion University “Receptor G-Protein Desensitization Regulators: Involvement of Alterations in mRNA and Protein Expression in the Pathogenesis and Treatment of Major Depression” Rene Anand, Ph.D. Ohio State University “Dysfunctional Modulation of Nicotinic Receptors in Schizophrenia” Celso Arango, M.D., Ph.D. Hospital General Universitario Gregorio Maranon “Safety and Tolerability of Antipsychotic Drugs in Children and Adolescents” Alberto Ascherio, MD, DrPH Harvard University “Prospective Study of Depression in a Large Cohort of Nurses” Sabine Bahn, M.D., Ph.D., M.R.C. Psych. University of Cambridge “Abnormal T-Cell Function in Schizophrenia Reflects Peripheral Abnormalities and Provides a Means of Detecting Global Deficits in Signalling, Gene Transcription, and Protein Expression” Samuel A. Ball, Ph.D. Yale University ”Psychotic-Spectrum Personality Disorders in Homeless Persons” Michael Bauer, M.D., Ph.D. Charite University Medicine Berlin “Thyroid Hormone and Mood Modulation in Bipolar Disorder: Neurobiological Mechanisms” 2006 NARSAD Second-Year Grants Independent Investigators Richard G. Boles, M.D. Tony P. George, M.D. University of Southern California “mtDNA Sequence Variants and Predisposition Towards Depression” Yale University “Effects of Galanthamine on Neurocognitive Deficits in Smokers and Non-smokers with Schizophrenia” Kelly N. Botteron, M.D. Washington University “Diffusion Tensor Imaging in Early-Onset Affective Disorder: A Twin Study” Howard Gershenfeld, M.D., Ph.D. University of Texas Southwestern Medical Center at Dallas “Developing Biomarkers for Treatment-Resistant Depression” Todd S. Braver, Ph.D. Michael R. James, Ph.D. Washington University “Improving Prefrontal Cortex Function in Schizophrenia through Focused Training of Cognitive Control” Queensland Institute of Medical Research “Genetic Mapping of Schizophrenia Locus on Chromosome 2” Anne Buist, M.Med., M.D. Duke University “Metabolic Signatures of Antipsychotic Drugs in the Treatment of Schizophrenia” University of Melbourne “Relapse of Bipolar Affective Disorder in the Perinatal Period: Role of Sleep and Circadian Rhythm” William A. Carlezon, Jr., Ph.D. Harvard University “Role of SPROUTY in Neurogenesis and Antidepressant-like Effects in Rats” Gabriel Corfas, Ph.D. Rima F. Kaddurah-Daouk, Ph.D. Wendy R. Kates, Ph.D. State University of New York, Upstate Medical University “An fMRI Study of Genetic Modulation of Emotional Processing in Velocardiofacial Syndrome” Ilana Kremer, M.D. Harvard University “Neuregulin-1-erbB Signaling and Schizophrenia” Technion-Israel Institute of Technology “Genetic Predisposition to Metabolic Syndrome and Type II Diabetes in Schizophrenia Patients” Joseph F. Cubells, M.D., Ph.D. Mark Laudenslager, Ph.D. Emory University School of Medicine “Genetics of Interferon-Alpha-Induced Depression” University of Colorado at Denver and Health Sciences Center “Salivary Cortisol and DHEA as a Valid Biomarker in Bipolar Disorder: Insights into Outcomes” Faith B. Dickerson, Ph.D., M.P.H. University of Maryland “Functional Recovery in Bipolar Disorder: The Role of Neurocognitive Factors” Anne Duffy, M.D. McGill University “Integrative Prospective Studies Among the Offspring of Well-Characterized Bipolar Parents” Cynthia Neill Epperson, M.D. Yale University “Serotonin, Neurosteroids and GABA Contributions to SSRI Treatment Response in PMDD: A 1H-MRS Study” Jeffrey D. Erickson, Ph.D. Louisiana State University “Scaling of Vesicular Glutamate and GABA Storage in Neocortical Synapses” Monika Fleshner, Ph.D. University of Colorado, Boulder “Prevention of Negative Behavioral Effects of Acute Fluoxetine: Role of BDNF” Liisa A.M. Galea, Ph.D. University of British Columbia “Models of Postpartum Depression: Effects on Behavior, Stress Reactivity and Hippocampal Neurogenesis in Both Mother and Offspring” Daniel Levesque, Ph.D. University of Montreal “Identification of Genes Associated with Nur77-Dependent Transcriptional Activity in Antipsychotic Drug Actions” A. Kimberly McAllister, Ph.D. University of California, Davis “Regulation of NMDAR Trafficking and Function by Class I MHC Molecules” Paul J. Moberg, Ph.D., ABPP University of Pennsylvania Medical School “Olfactory Dysfunction in Schizophrenia: A Model System to Investigate Aberrant Neurodevelopment” Terence J. O'Brien, M.D. University of Melbourne “The Effects of Hypercortisolaemia on Limbic Epileptogenesis” Arturas Petronis, M.D., Ph.D. University of Toronto “Epigenomic Profiles in Major Psychiatric Disease: The First 15 Percent of the Genome” Mary Phillips, M.D. University of Pittsburgh “Defining the Neural Markers of Bipolar Disorder: A Functional Neuroimaging Study” Teodor T. Postolache, M.D. University of Maryland “Relationship between Allergen Specific IgE Antibodies and Exacerbation of Recurrent Mood Disorders” 39 2006 NARSAD Second-Year Grants Independent Investigators Delbert Robinson, M.D. Martin H. Teicher, M.D., Ph.D. Albert Einstein College of Medicine “Long-Acting Risperidone for Patients Who Fail Their First Antipsychotic Treatment Trial” Harvard University “Early Stress and the Neurobiology of Depression” Ronnen H. Segman, M.D. Stanford University “Declarative Memory in Schizophrenia: fMRI of Hippocampal Subfield Function” Hebrew University “Peripheral Blood Mononuclear Cell Gene Expression Profiling of Postpartum Depressive Disorder” Anne B. Sereno, Ph.D. University of Texas Health Science Center at Houston “Effects of Dopaminergic Medications on Orienting in Schizophrenia” Yvette I. Sheline, M.D. Washington University “Decreased White Matter Connectivity in Late-Life Depressions” Karen E. Stevens, Ph.D. University of Colorado at Denver and Health Sciences Center “Gestational Choline Supplementation for the Amelioration of Sensory Inhibition Deficits” 40 Anthony D. Wagner, Ph.D. Mark Allen Whisman, Ph.D. University of Colorado, Boulder “Prospective Associations Among Genes, Stress and Depression” Kimberly A. Yonkers, M.D. Yale University “A Controlled Study of SSRI Exposure in Neonates” Carlos A. Zarate, M.D. National Institute of Mental Health “An Investigation of Glutamatergic Modulators as Pharmacologic Strategies to Bring Rapid (Next Day) and Sustained Antidepressant Effects” 2006 NARSAD Grants Young Investigators R. Alison Adcock, M.D., Ph.D. Saloua Benmansour, Ph.D. University of California, San Francisco “Correlated Activation in Midbrain and Hippocampus as a Predictor of Memory: fMRI in Schizophrenia and Control Subjects” University of Texas Health Science Center at San Antonio “Influence of Ovarian Hormones on the Interaction Between Antidepressants and Serotonin Transporters” Evdokia Anagnostou, M.D. Gregor E. Berger, M.D. Mount Sinai School of Medicine “Brain Glutamate Concentrations in Autistic Adolecents by Magnetic Resonance Spectroscopy” University of Melbourne “Genetic Modulators of Clinical and Neurobiological Outcomes in Early Psychosis: A Genotype to Phenotype Approach” Julie Audet, Ph.D. Zubin Bhagwagar, M.D. University of Toronto “Effect of Lithium on Signal Transduction Dynamics in Somatic Stem Cells” Yale University “A Proton MRS Study of GABA and 5-HT Interactions” David A. Baker, Ph.D. Emory University “Chaperones of the Glucocorticoid Receptor, Depression and Early-Life Stress” Marquette University “Cystine-Glutamate Exchange and the Phencyclidine Model of Schizophrenia” Ranita Basu, M.D. University of Pittsburgh “Psychosocial Stress, Cortisol and Insulin Resistance and Risk of Cardiovascular Disease in Schizophrenia” Anita Bechtholt, Ph.D. University of Pennsylvania “Examining the Mechanisms of Chronic Antidepressant Efficacy” Cecile Beguin, Ph.D. Harvard University “Synthesis and Evaluation of Salvinorin A Analogues as Kappaopioid Receptor Ligands for the Treatment of Mood Disorders” Elisabeth Binder, M.D., Ph.D. Hugh T. Blair, Ph.D. University of California, Los Angeles “Modulation of Serotonergic Neural Activity by Fear and Anxiety” Sondra Bland, Ph.D. University of Colorado, Boulder “Mechanisms of Stressor Controllability Modulation of Stressinduced Changes in Neurogenesis and Basic Fibroblast Growth Factor Expression in the Rat Hippocampus” 2006 NARSAD Grants Young Investigators William Bobo, M.D. Zafiris Daskalakis, M.D., Ph.D., FRCP Vanderbilt University “Effect of Addition of Modafinil (MOD) on the Tolerability and Efficacy for Cognition to Atypical Antipsychotic Drugs in Patients with Schizophrenia (SCH) or Schizoaffective Disorder (SCHAD)” University of Toronto “Enhancing Working Memory Performance and Gamma Band Synchrony in Patients with Schizophrenia Using Repetitive Transcranial Magnetic Stimulation (TMS)” Maura Boldrini, M.D., Ph.D. Carmen de Groote, Ph.D. Columbia University “Tryptophan Hydroxylyases Protein in the Raphe Nucleus from a Matched Set of Subjects with Bipolar Disorder, Depression, Schizophrenia and Controls with and without Suicide” University of Manchester “In Vivo Magnetic Resonance Imaging of Glutamate and GABA Transmission in Schizophrenia” David Cristopher Bragg, Ph.D. University of Toronto “Suicide in Major Psychosis: Parent of Origin Effect and Genomic Imprinting in Serotonin and Norepinephrine System Genes” Harvard University “Analysis of DISC1 and its Role in Neurite Outgrowth and Synapse Formation” Allegra Broft, M.D. Columbia University “Imaging of Dopamine Systems in Bulimia Nervosa” Vincenzo De Luca, M.D. J. Bruno Debruille, M.D., Ph.D. McGill University “Neurocognitive Mechanisms Underlying the Maintenance of Delusions: A Longitudinal Study in First Psychotic Episode Patients” Peter Bulow, M.D. Gabriel S. Dichter, Ph.D. Columbia University “Treating Depression with Transcranial Direct Current Stimulation” University of North Carolina-Chapel Hill “The Neural Influence of Affective Dysregulation on Executive Function in Unipolar Major Depression” Edgar A. Buttner, M.D., Ph.D. Harvard University “Pharmacogenomics of Caenorhabditis Elegans Used to Discover Novel Genetic Targets of Psychoactive Medications” Daniel P. Dickstein, M.D. Brown University “Reversal Learning in Pediatric Bipolar Disorder” Dara M. Cannon, Ph.D. Anna Dobretsova, Ph.D. National Institute of Mental Health “Dopamine Receptor Imaging in Mood Disorders” University of Arkansas for Medical Sciences “Neuron-oligodendrocyte Interactions in a Developmental Model of Schizophrenia” Eran Chemerinski, M.D. Mount Sinai School of Medicine““ Cognitive Enhancement in the Schizophrenia Spectrum with Dihydrexidine” Sufen Chiu, M.D., Ph.D. University of California, Davis “Pediatric Psychosis and Schizophrenia” Kodavali Venkata Chowdari, Ph.D. University of Pittsburgh “Mechanisms of Altered GAD67 and mRNA Expression in Schizophrenia” Alex Dranovsky, M.D., Ph.D. Columbia University “Effects of Stress and Antidepressants on Cellular and Circuit Plasticity of Adult-Born Hippocampal Neurons” Michael R. Drew, Ph.D. Columbia University “The Role of Adult Hippocampal Neurogenesis in Fear Conditioning” Cristiane S. Duarte, Ph.D., M.P.H. Columbia University “Childhood Depression and Obesity: Correlates and Pathways” Francesca Cicchetti, Ph.D. Helen Link Egger, M.D. Laval University “The Role of Inflammation in Schizophrenia” Duke University “Four Year Functional MRI Follow-up of Preschoolers with and without Anxiety Disorders” Anis Contractor, Ph.D. Northwestern University “Dopaminergic Regulation of Excitatory Synapses in the CA3 Region of the Hippocampus” Naomi Eisenberger, Ph.D. University of California, Los Angeles “An fMRI Study of Cytokine-Associated Depression and Social Pain” Donald Channing Cooper, Ph.D. James C. Eliassen, Ph.D. University of Texas Southwestern Medical Center at Dallas “The Molecular and Physiological Signature of Psychosis in the Hippocampal Prefrontal Cortical Pathway” University of Cincinnati “Identifying a Neurochemical Basis for fMRI Abnormalities in Bipolar Disorder with Phosphorus MRSI” Miles G. Cunningham, M.D., Ph.D. Oleg V. Evgrafov, Ph.D., D.Sc. Harvard University “A Developmental Model for Structural Defects in Schizophrenia” University of Southern California “Identification of Genes Involved in Etiology of Schizophrenia by Expression Profiling” 41 2006 NARSAD Grants Young Investigators Andrea Faedo, Ph.D. Belinda Garner, Ph.D. University of California, San Francisco “Role of Tbr1 in Glutamergic Neuron Differentiation: Implications for Schizophrenia” University of Melbourne “Glucocorticoid Receptor Function in First-Episode Psychosis and in Individuals at Ultra High Risk for Psychosis” Peter A. Fahnestock, M.D. Anthony J. Giuliano, Ph.D. Washington University “Effects of Antipsychotic Medications on Energy Intake and Expenditure” Harvard University Stress Reactivity in Individuals at Genetic and Clinical High Risk Schizophrenia” Christopher P. Fall, Ph.D. Stephen J. Glatt, Ph.D. University of Illinois, Chicago “Neuromodulation of Network Activity in Prefrontal Cortical Microcircuits” State University of New York, Upstate Medical University “Re-Establishing DRD2 as a Risk Gene for Schizophrenia: Haplotype Mapping and Family-Based Association Analysis” Jin Fan, Ph.D. Joseph A. Gogos, M.D., Ph.D. Mount Sinai School of Medicine “Selective Impairment of Attentional Networks and Treatment Effects of Attentional Functions in Schizophrenia” Columbia University “Hippocampal Structure and Function in a BDNF Val66Met Knock-in Mouse Strain” Vincent P. Ferrera, Ph.D. Stephen J. Gold, Ph.D. Columbia University “Risk and Reward in Dorsolateral Prefrontal Cortex” University of North Texas “Regulator of G-Protein Signaling 10 (RGS10): A Novel Modulator of Muscarinic Receptor Signaling” Marc Flajolet, Ph.D. 42 Rockefeller University “Identification of Adenosine A2A Receptor Regulatory Proteins to Interfere with Dopamine D2 Signaling Pathway” Rachel Helena Flomen, Ph.D. University of London “Identification of Functional Variant(s) in the CHRNA7 Region of 15q13-q14 that Predispose to P50 Sensory Gating Deficit and to Smoking Risk in Psychosis” Stan B. Floresco, Ph.D. University of British Columbia “Neural Encoding in the Prefrontal Cortex During Set Shifting: Alteration by NMDA Antagonists” Erika E. Forbes, Ph.D. University of Pittsburgh “A Neuroimaging Study of Positive Affect in Current and Remitted Adolescent Depression” Cynthia H.Y. Fu, M.D., MSc, FRCPC University of London “The Serotonin Transporter Polymorphism, Cerebral Endophenotypes and Depression” Catherine A. Fullerton, M.D., M.P.H. Harvard University “Utilizing Mecamylamine to Examine the Cognitive Effects of Nicotinic Acetylcholine Receptors in Smokers and Non-smokers with Schizophrenia” Amelia Gallitano-Mendel, M.D., Ph.D. Washington University The Effect of Antipsychotic Treatment on a Genetic Mouse Model of Schizophrenia” Keming Gao, M.D., Ph.D. Case Western Reserve University “A Pragmatic Clinical Effectiveness Trial in Multi-morbid Anxious Patients with Bipolar I or II” Doron Gothelf, M.D. Tel Aviv University “Are Variants of the COMT Gene a Risk Factor for Longitundinal Decline in Prefrontal Volumes, Reduced Cognitive Performance, and Development of Psychosis in Adolescents with 22q11.2 Deletion Syndrome?” Melissa Green, Ph.D. Macquarie University “Remediation of Facial Emotion Perception in Psychotic Disorders” Cornelius Gross, Ph.D. European Molecular Biology Laboratory “Identifying Susceptibility Genes for Mood Disorders Using SNP Analysis in the Mouse” Eugenia V. Gurevich, Ph.D. Vanderbilt University “The Role of Arrestins in Neurodevelopment: Implications for Schizophrenia” Kent C. Harris, Ph.D. Huntington Medical Research Institute “Direct Detection of Glial Glutamate Function in Schizophrenia with 13C Acetate MR Spectroscopy” Allison G. Harvey, D.Phil. University of California, Berkeley “Sleep Disturbances, Emotion Regulation and Bipolar Disorder” Takanori Hashimoto, M.D., Ph.D. University of Pittsburgh “Alterations in Cortical Inhibitory Circuitry in Schizophrenia, Regional Specificity and Compensatory Mechanism” Kanehiro Hayashi, Ph.D. University of Texas Southwestern Medical Center at Dallas “Regulatory Mechanisms of Cytoskeletal Dynamics in Schizophrenia” 2006 NARSAD Grants Young Investigators Elizabeth P. Hayden, Ph.D. Pascal S. Kaeser, M.D. University of Western Ontario “Genetic and Environmental Influences on Temperament in Preschoolers” University of Texas Southwestern Medical Center at Dallas “Creating Mouse Models for Understanding Molecular Mechansims of Schizophrenia” Shawn Hayley, Ph.D. Theodore S. Kalbfleisch, Ph.D. Carleton University “Depressive-like Illness Provoked by Stressor and Interferonalpha: Endogenous Cytokine Mechanisms” University of Louisville “Development of Bioinformatics Infrastructure in Support of Biomarker Discovery in Schizophrenia Studies” Peter B. Hedlund, M.D., Ph.D. Jessica H. Kalmar, Ph.D. The Scripps Research Institute “The 5-HT7 Receptor - The Missing Link in Depression?” Yale University “Developing Neurobehavioral Endophenotypes to Dissociate Pediatric Bipolar Disorder from Attention-Deficit/Hyperactivity Disorder” Aude Henin, Ph.D. Harvard University “Magnetic Resonance Spectroscopy in Children at Risk for Bipolar Disorder” Kameel N. Karkar, M.D. Loren Keith Henry, Ph.D. University of California, San Francisco “Cellular and Molecular Characterization of Tangential Migration Mutants” Vanderbilt University ”Structure-base Modeling of the Serotonin Transporter to Elucidate Sites of Antidepressant Action and Psychiatric DiseaseAssociated Mutations” University of Sydney “Conditional NPY Y1 Receptor Deficient Mice: A Potential New Animal Model for Schizophrenia?” Carrie L. Heusner, Ph.D. University of California, Los Angeles “Identification of Synaptic Molecules that Signal to the Nucleus During Neuronal Plasticity” Daphne J. Holt, M.D., Ph.D. Harvard University “Spatiotemporal Imaging of Emotional Salience in First-Episode Schizophrenia” Jinger G. Hoop, M.D. Medical College of Wisconsin “Genetic Testing for Schizophrenia: Views of Patients, Families, and Clinicians” Yue-Qiao Huang, Ph.D. Drexel University “Molecular Mechanism of NMDA Receptor Endocytosis” Dan V. Iosifescu, M.D. Harvard University “Brain GABA Levels and Treatment Response in Major Depressive Disorder” Hank P. Jedema, Ph.D. University of Pittsburgh “The Influence of the Bed Nucleus of the Stria Terminalis on Monoaminergic Ventral Tegmental Area and Locus Coeruleus Neurons Following Chronic Stress Exposure” Jutta Joormann, Ph.D. Stanford University “Stress Reactivity and Emotion Regulation in Children at Risk for Depression” Mario Francisco Juruena, M.D. University of London “Mineralocorticoid Receptor Function in Treatment-Resistant Depressed Patients: Response to Prednisolone Suppression Test” Tim Karl, Ph.D. Tod E. Kippin, Ph.D. University of California, Santa Barbara “Antipsychotic Drug Regulation of Neural Stem Cells and Neurogenesis in the Adult Mammalian Brain: Role of Dopamine D2 Receptors and Relation to Clinical Efficacy” Yoav Kohn, M.D. Hebrew University “Identification of Genes for Psychiatric Disorders in a Genetic Isolate from Israel” Sila Konur, Ph.D. University of California, San Francisco “Evaluation of a Developmental NMDA Receptor Hypothesis for Schizophrenia” Sandra J. Kuhlman, Ph.D. Cold Spring Harbor Laboratory “Role of GAD67-mediated GABA Synthesis in the Maturation and Dynamics of GABAergic Synapses and Innervation in Mouse Frontal Cortex” Po-Hsiu Kuo, Ph.D. Virginia Commonwealth University “Genetics in the Comorbidity of Major Depression and Alcohol Dependence” Matthew M. Kurtz, Ph.D. Yale School of Medicine “Cognitive Remediation for Schizophrenia: Effects on Distal Outcome Measures and Relationship to Social-Skills Training” Cecile D. Ladouceur, Ph.D. University of Pittsburgh “Neural Circuitry Underlying Emotion Regulation in Adolescents at High Risk of Bipolar Disorder” Yulia Landa, Psy.D. Cornell University “Cognitive Behavioral Therapy for Paranoia in Schizophrenia” 43 2006 NARSAD Grants Young Investigators Maria Danet S. Lapiz, Ph.D. Sanjay J. Mathew, M.D. University of Texas Health Science Center at San Antonio “Effect of Chronic Cold Stress on Cognitive Flexibility in the Rat Attentional Set Shifting and Reversal with Chronic Antidepressant Treatment” Mount Sinai School of Medicine “Continuation Riluzole in the Prevention of Relapse Following Ketamine” Amanda J. Law, Ph.D. University of California, Los Angeles “Investigating the Role of 14-3-3 eta in Schizophrenia” University of Oxford “Molecular and Functional Characterization of Type IV, Neuregulin-I, a Novel Isoform Associated with Genetic Risk for Schizophrenia” Royce Lee, M.D. University of Chicago “A Pilot Study of the Effect of Intranasal Corticotropin-Releasing Hormone on Emotion Processing in Remitted Depression” Boaz Levy, Ph.D. Harvard University “Recovery of Cognitive Functioning in Bipolar Patients with a Comorbid Substance Use Disorder 3 Months after Discharge” Zhi Li, Ph.D. Johns Hopkins University “Abnormal Dendritic Trafficking of Val66Met BDNF: Role of the Translin/Trax RNA Binding Complex” 44 Gregory A. Light, Ph.D. University of California, San Diego “Neurophysiological Biomarkers as Targets for Assessing Functioning in Schizophrenia” Julie Linker, Ph.D. Virginia Commonwealth University “Genetic and Environmental Risk Factors for Suicidal Behavior in Depressed Youth” Daniel Lodge, Ph.D. University of Pittsburgh “Afferent Modulation of Dopamine System Responsivity in an Animal Model of Schizophrenia” Falk W. Lohoff, M.D. University of Pennsylvania “Shared Bipolar/Schizophrenia Susceptibility Genes on Chromosome 8p” Victor A. Lopez-Soto, M.D. University of Texas Health Science Center at San Antonio “Gene-Environment Interaction Study of the Serotonin Transporter and Tryptophan Hydroxlase-2 in War Survivors with Depression and Suicidal Behavior” Rajnish Mago, M.D. Thomas Jefferson University “Antidepressant-Induced Excessive Sweating: Measurement and Treatment with Terazosin” Francoise S. Maheu, Ph.D. National Institute of Mental Health “Neural Circuits Underlying Rewarding Social Interactions and Depression: Influence of Maltreatment on Brain Development in Adolescents Study” Anna Matynia, Ph.D. Clinton B. McCracken, Ph.D. University of Pittsburgh “Effects of Deep Brain Stimulation on Afferent Regulation of Nucleus Accumbens Neuronal Activity” Mayank Mehta, Ph.D. Brown University “Influence of NMDA Antagonists on Hippocampal Dynamics” José J. Miguel-Hidalgo, Ph.D. University of Mississippi Medical Center “Glutamatergic Markers of Astrocytes in Major Depression with Comorbid Alcoholism” Peter Milev, M.D., Ph.D. University of Minnesota “Functional Anatomy of Illusory Contour Perception in People with Schizophrenia and its Relationship with In Vivo Measures of GABA and Glutamate: Functional MRI and 7 T Magnetic Resonance Spectroscopy Studies” Marc J. Miresco, M.D. McGill University “Genetic-Environmental Determinants of the Development of Impulsivity Traits in Children” Serge A. Mitelman, M.D. Mount Sinai School of Medicine “Five-Year Longitudinal Diffusion-Tensor Imaging Assessment of White Matter in Schizophrenia” Ganeshwaran H. Mochida, M.D., M.M.Sc. Harvard University “Genes for Developmental Disorders of the Human Cerebral Cortex” Sarita A. Mohanty, M.D., MPH University of Southern California “Improving Depression Care for the Medically Indigent in a County Emergency Department” Anna M. Muller, Ph.D. University of California, Los Angeles “Investigating the Impact of a Skills-based Intervention Program on Insight and Engagement in Follow-up Psychiatric Care” Inez Myin-Germeys, Ph.D. Maastricht University “Stress Reactivity in Psychosis: Linking Phenomenology, Neurobiology and Genetics” Syed Naqvi, M.D. University of California, Los Angeles “PUFA Augmentation for Treatment of Adolescent Unipolar Major Depression” 2006 NARSAD Grants Young Investigators Raad Nashmi, Ph.D. Koraly Perez-Edgar, Ph.D. California Institute of Technology “Examining Mechanisms of Nicotine Addiction Using Knock-in Mice with Fluorescently Labeled a4 Nicotinic Receptors” George Mason University “Assessing the Molecular Genetic Links Between Early Temperament and Psychopathology in Adolescence: The Potential Role of Dopamine (DRD4), Serotonin (5HTT), and Corticotropin-Releasing Hormone (CRH)” Matthew Nolan, Ph.D. University of Edinburgh “A Genetic Approach to Investigating the Contribution of the Cerebellum to the Symptoms of Schizophrenia” Sherie Lynn Novotny, M.D. University of Medicine & Dentistry of New Jersey “Oxcarbazepine vs. Placebo in Childhood Autism” Peter Olausson, Ph.D. Yale University “Chronic Corticosterone Exposure as a Novel Animal Model of Depression: A Proteomics Analysis” Urban Osby, M.D., Ph.D. Karolinska Institute “Genetic Risks for Suicide in Schizophrenia” Thaddeus W.W. Pace, Ph.D. Emory University School of Medicine “Inflammatory Signaling and Glucocorticoid Receptor Function in Patients with Major Depression” Silvia Paddock, Ph.D. Karolinska Institute “Identification and Characterization of Susceptibility Genes for Bipolar Affective Disorder: Multi-Gene Mining and Studies of GRIK2” Tracie Ann Paine, Ph.D. Harvard University “Role of Protein Kinase A and CREB in the Medial Prefrontal Cortex in Attention: Relationship to Schizophrenia” Abraham A. Palmer, Ph.D. University of Chicago “Genetic Studies of Fear Learning in Mice and Humans” Michael V. Pantalon, Ph.D. Yale University “Efficacy of Motivational Adherence Enhancement for Bipolar Post-Partum Women” Sergio Paradiso, M.D., Ph.D. University of Iowa “Social Perception-related Brain Activity in Schizophrenia Patients Treated First with Haloperidol and then with Novel Antipsychotics” Sang Ki Park, Ph.D. Pohang University of Science and Technology “Par-4 in Dopamine Signaling and Mood Disorders” Mani N. Pavuluri, M.D., Ph.D. University of Illinois, Chicago “fMRI Study of the Cognitive and Affective Circuitry Dysfunction in Pediatric Bipolar Disorder” Roy H. Perlis, M.D. Harvard University “Pharmacogenomics of Antidepressant-emergent Adverse Effects in Major Depressive Disorder” Benjamin D. Philpot, Ph.D. University of North Carolina-Chapel Hill “Synaptic Basis for NMDA Receptor Hypofunction in Schizophrenia” Elizabeth M. Powell, Ph.D. University of Maryland “Rescue of GABAergic Cell Loss: Anatomical and Behavioral Profiles” Andrew P. Prescot, Ph.D. Harvard University “TE-Averaged Proton Magnetic Resonance Spectroscopy: Monitoring the Effects of High-Dose Oral Glycine Loading on Brain Glycine Levels in Patients with Schizophrenia” Gilbert A. Preston, M.D. University of Utah “Alpha Frequency rTMS Improves Memory Encoding in Healthy Persons” Patrick Provost, Ph.D. Laval University “A Link Between RNA Interference, microRNAs and Alzheimer's Disease” Marita Pruessner, Ph.D. McGill University “Cortisol Regulation and its Association with Hippocampal Volume in Individuals at Ultra-High Risk for Psychosis” Shaun Matthew Purcell, Ph.D. Harvard University “A Gene-Based Approach to Epistatic Gene-Gene Interaction in Common Neuropsychiatric Disease” David C. Purselle, M.D. Emory University “Diagnostic Mediators of Suicidal Behavior in African-Americans” Jason J. Radley, Ph.D. Salk Institute for Biological Studies “Differential Role of the Medial Prefrontal Cortex in Neuroendocrine and Autonomic Responses to Psychological Stress” Wiveka Ramel, Ph.D. Stanford University “Vulnerability and Depressive Relapse: An fMRI Study of MoodMemory Relations” Michael A. Rapp, M.D., Ph.D. Mount Sinai School of Medicine “Neuroplasticity Genes and Gene Products in Recurrent Major Depression” 45 2006 NARSAD Grants Young Investigators Ann M. Rasmusson, M.D. Salomao Segal, M.D. Yale University “Neurobiological Predictors of Response to Cognitive Processing Therapy for PTSD in Women with and without Major Depression” Columbia University “Neurochemistry, Neuropsychology, and Behavior of Deep Brain Stimulation in the Cingulate Bundle” Amir Raz, Ph.D. Daniel Senkowski, Ph.D. McGill University “Attentional Regulation of Affect and Cognition in Impulse Control Disorders” University Hospital of Hamburg “The Cocktail Party Phenomenon in Schizophrenia” Eleonore Real, Ph.D. Yale University “Characterization of a Novel Candidate Gene in Schizophrenia” Cold Spring Harbor Laboratory “Molecular Mechanisms Controlling Intracellular AMPA Receptor Trafficking” Lise Rioux, Ph.D. Drexel University College of Medicine “Neuregulins and Olfactory Bulb Plasticity in Schizophrenia” Victoria Blythe Risbrough, Ph.D. University of California, San Diego “Developing Behavioral and Neuroimaging Markers of Trait Anxiety” Melissa M. Rolls, Ph.D. Pennsylvania State University “Identification of Proteins Required for Neuronal Compartmentalization” 46 Susan Lee Rossell, Ph.D. University of Melbourne “Using Ketamine to Model Thought Disorder” Laura M. Rowland, Ph.D. University of Maryland “Neural Changes Associated with Successful Learning in Schizophrenia” Kristine Roy, Ph.D. Harvard University “The Role of Neuregulin-erbB Receptor Signaling in Oligodendrocyte Development and Behavior” Scott J. Russo, Ph.D. University of Texas Southwestern Medical Center at Dallas “The Role of Ventral Tegmental Area AKT Signaling Proteins in Depression-Related Behaviors and Neuronal Morphology” Amar Sahay, Ph.D. Columbia University “Molecular Mechanisms Underlying the Sensitive Period for Anxiety” Paola Salvatore, M.D. Harvard University “Comparison of Dimensional and Categorical Representations of the Psychopathology of Psychotic Disorders” Rebecca Seal, Ph.D. University of California, San Francisco “The Role of Glutamate Release by Monoamine Neurons” Thomas W. Sedlak, M.D., Ph.D. Johns Hopkins University “The Role of Heme Oxygenase in the Oxidative Stress of Alzheimer's Disease” Nenad Sestan, M.D., Ph.D. Simone G. Shamay-Tsoory, Ph.D. University of Haifa “Characterization of Theory of Mind and Empathy Deficits in Schizophrenia: A Neuropsychological Examination of Affective vs. Cognitive Aspects of Social Cognition” Jiajun Shi, Ph.D. University of Chicago “Association of Neurogenesis and Neuroplasticity Genes with Bipolar Disorder” Peter Siekmeier, M.D. Harvard University “The Use of a Neurocomputational Model to Examine Hippocampal Etiologies of Schizophrenia and Develop More Effective Psychopharmacologic Treatments” Alan Simmons, Ph.D. University of California, San Diego “Differences in Neural Structure and Functioning of PTSD Patients Involving Affective Processing” Naomi M. Simon, M.D. Harvard University “Bipolar Disorder, Chronic Stress, and Accelerated Aging” Monsheel S.K. Sodhi, MRPharmS, MSc, Ph.D. Vanderbilt University “The Impact of Post-Transcriptional and Epigenetic Factors on the Psychopathy of Schizophrenia” Chantal Martin Soelch, Ph.D. National Institute of Mental Health “Relationship Between Reward Learning, Dopaminergic Function and Anhedonia in Depression: An Event-Related fMRI Study” Carl W. Stevenson, Ph.D. University of Nottingham “Effects of Early Adversity on Prefrontal Cortex Function During Aversive Learning” Holly A. Swartz, M.D. University of Pittsburgh “Psychotherapy for Bipolar II Depression” Sharif A. Taha, Ph.D. University of California, San Francisco “Neural Encoding of Cue Associations in the Nucleus Accumbens During Latent Inhibition” 2006 NARSAD Grants Young Investigators Yilang Tang, M.D. Arthur Westover, M.D. Emory University “Biochemical Genetics of Catechol O-Methyltransferase” University of Texas Southwestern Medical Center at Dallas “Outcomes of Managed Care in the Texas Public Mental Health System” Cenk Tek, M.D. Yale University “Mental Transformations in Schizophrenia in Relation to Negative Symptoms and Deficit Syndrome” Dawn Thompson, Ph.D. University of California, San Francisco “GASP and the Trafficking of the Dopamine Receptor Family” Sebastien Thuault, Ph.D. Columbia University “Identifying the Molecular and Cellular Mechanisms of Working Memory Using a Dual Transgenic Approach” Paula Ulery, M.S., Ph.D. University of Texas Southwestern Medical Center at Dallas “Role of N-Terminus Phosphorylation on Syntaxin-1 Activity: Implications for Neurotransmitter Release” Stefan Ursu, M.D., Ph.D. University of California, Davis “The Relationship Between Reward Processing, Orbitofrontal Cortex Dysfunction and Negative Symptoms in Unmedicated Schizophrenia Patients: A Functional MRI Exploration” Vladimir Vladimirov, M.D., Ph.D. Virginia Commonwealth University “Assessment of the Expression and Activation of Cell Survival Molecules in the P13K/AKT Pathway in Schizophrenia” Jacob A.S. Vorstman, M.D. Utrecht University “Clinical and Genetic Aspects of Psychosis in the 22q11.2 Deletion Syndrome” Carole Weaver, Ph.D. University of California, San Diego “The Role of the Lithium Target GSK3 in the Regulation of Axonal Transport” Tonya Jo White, M.D. University of Minnesota “Study of Prefrontal Structure and Function in Children and Adolescents with Velocardiofacial Syndrome” Janet M. Witte, M.D., M.P.H. Harvard University “A Double-Blind, Placebo-Controlled Study of Acamprosate Added to Escitalopram and Behavioral Treatment in Major Depressive Disorder with Comorbid Alcohol Abuse/Dependence” Todd S. Woodward, Ph.D. University of British Columbia “Dysconnectivity of Hippocampo-Prefrontal Neural Systems in Schizophrenia” Houhui Xia, Ph.D. Louisiana State University “Differential Effects on CREB Inactivation by Class-I HDAC Proteins in Depression” Jian Xu, Ph.D. Salk Institute for Biological Studies “New Knockout Mice of Kainate Receptors, Genes Associated with Schizophrenia and Depression” Qing Xu, Ph.D. Cornell University “Identifying Early Markers of Cortical Interneuron Subtypes” Jamie M. Zeitzer, Ph.D. Stanford University “Sleep Regulation, Depression and Hypocretin” Hanting Zhang, M.D., Ph.D. West Virginia University “Regulation of Adult Neurogenesis by Cyclic AMP-Specific Phospohodiesterase 4 (PDE4)” Amy Wenzel, Ph.D. Xiaodong Zhang, Ph.D. University of Pennsylvania “Cognitive and Behavioral Predictors of Suicide Behavior in Suicide Attempters” Duke University “Functional Analysis of Neuronal-specific Tryptophan Hydroxylase-2 (TPH2)” Anne E. West, M.D., Ph.D. Meng-Yang Zhu, M.D., Ph.D. Duke University “Regulation of Activity-Dependent GABAergic Synapse Development by Brain-Derived Neurotrophic Factor” East Tennessee State University “Phox2 Genes, Neurogenes, and Depression” Mark J. Zylka, Ph.D. University of North Carolina-Chapel Hill “Contribution of Mrgprd-Expressing Pain Circuits to Psychiatric Disorders” 47 2006 NARSAD Second-Year Grants Young Investigators Ofer Agid, M.D. Anirban Basu, Ph.D. University of Toronto “Differentiating the Roles of Striatal vs. Extrastriatal Dopamine D2 Receptors in Antipsychotic Response” University of Chicago “Estimating Risks and Costs of Cardiovascular Diseases Associated with the Long-Term Use of Atypical Antipsychotics in Schizophrenia” Maricela Alarcon, Ph.D. University of California, Los Angeles “Identification of Genes for Autism and its Endophenotypes” Nelly Alia-Klein, Ph.D. Brookhaven National Laboratory “Endophenotypes of Inhibitory Control in a Group of Alcoholic Domestic Abusers” Patrick Allen, Ph.D. Yale University “Regulation of Glutamate Receptor Function via the PP1 Regulatory Subunit Neurabin” Mark Alter, M.D., Ph.D. Columbia University “Examination of Maternal Effects on Transmission of Behavioral Phenotype in 5-HT1AR Knockout Mice” Maria Cecilia Angulo, Ph.D. Université René Descarte “Neuron-glia Interactions Mediated by Nicotinic Acetylcholine Receptors: A Putative Cellular Mechanism for Schizophrenia and Tobacco Addiction” Mark Ansorge, Ph.D. 48 Columbia University “Consequences of SERT Inhibition During Development on Adult Behavior and Neurophysiology” Masato Asai, M.D., Ph.D. Harvard University “Role of Neuron Restrictive Silencing Element in Controlling CRH Expression in the Brain” Dimitrios Avramopoulos, M.D., Ph.D. Johns Hopkins University “Characterization of the Neuregulin-3 gene, a Positional and Functional Candidate for Schizophrenia” Bettina Bankier, M.D. Medical University of Vienna “Impact of Major Depressive Disorder and Anxiety Disorders on Inflammation in Stable Coronary Heart Disease Patients” Naama Barnea-Goraly, M.D. Stanford University “Investigation of White Matter Structure in Children and Adolescents with Autism, Their Autism-Discordant Siblings, and Controls: A Diffusion Tensor Imaging Study” Selena E. Bartlett, Ph.D. University of California, San Francisco “Dopamine Receptor Trafficking and the Modulation of Mesolimbic Dopamine Responses” Celyne Bastien, Ph.D. Laval University “Hypervigilance in BPD: Event-Related Potentials Measures of Cognitive Information Processing During Wake and Sleep” Martin Beaulieu, Ph.D. Duke University “Akt/GSK3 Signaling Cascade and the Action of Dopamine” Jean-Claude Beique, Ph.D. Johns Hopkins University “Investigation of the Role of SAP102 in Controlling NMDA Receptor Function: Possible Link with the NMDA Receptor Hypofunction Hypothesis of Schizophrenia” Monica Beneyto, Ph.D. University of Pittsburgh “AMPA Receptor Trafficking Abnormalities in the Postsynaptic Density of the Schizophrenia Prefrontal Cortex” Dwight E. Bergles, Ph.D. Johns Hopkins University “Synaptic Signaling Between Neurons and Oligodendrocyte Precursor Cells: Modulation by Antidepressive Therapies and Glucocorticoids” Robert M. Berman, M.D., Ph.D. Columbia University “Testing Neurocircuitry of Antidepressant Response Using Focal Brain Stimulation” Olivier Berton, Ph.D. University of Texas Southwestern Medical Center at Dallas “Neuroplastic Adaptations of Mesolimbic Pathways in a Mouse Model of Stress-Induced Anhedonia: Role of BDNF Signalling” Gautam N. Bijur, Ph.D. University of Alabama at Birmingham “The Mood Stabilizing Drug Lithium Activates Calcium Signaling by Inhibiting Glycogen Synthase Kinase-3beta” Thomas A. Blanpied, Ph.D. University of Maryland “Molecular Exchange and Morphological Dynamics of Individual Postsynaptic Densities” Stefania Bonaccorso, M.D. Vanderbilt University “Does the Addition of Divalproex (VPA) Acid to Risperidone, Olanzapine or Aripiprazole Improve Cognition and Psychopathology in Outpatients with Schizophrenia or Schizoaffective Disorder?” Dominika Borek, Ph.D. University of Texas Southwestern Medical Center at Dallas “Structural and Biophysical Studies of G72 Protein and its Complex with D-Amino Acid Oxidase” Ugo Borello, Ph.D. University of California, San Francisco “Role of the Fgf and Wnt Genes in the Development of the Cerebral Cortex” 2006 NARSAD Second-Year Grants Young Investigators Stephanie L. Borgland, Ph.D. Deana Davalos, Ph.D. University of California, San Francisco “The Role of Orexins in Modulation Dopaminergic Neurotransmission: A Potential Novel Therapeutic Target for the Treatment of Schizophrenia” Colorado State University “Brain Abnormalities in Infants with Prenatal Maternal Depression” Karin Borgmann-Winter, M.D. University of Pennsylvania “Studies of the Neuroprotective Effects of Antipsychotics in Adolescent and Young Adult Psychosis” Elvira Bramon, M.D. University of London “Susceptibility Genes for Psychosis: A Family Study Combining Molecular Genetics and Neurophysiology” Susan A. Brunelli, Ph.D. Columbia University “Gene Expression and QTL Mapping in Rats Selectively Bred for Infant Anxiety” Darlene H. Brunzell, Ph.D. Yale University “Beta2* Nicotine Acetylcholine Receptors Affect Schizophrenia Phenotypes Via Modulation of CREB” Katherine Burdick, Ph.D. Albert Einstein College of Medicine “Neurocognitive Endophenotypes in Bipolar Disorder” Chadi A. Calarge, M.D. University of Iowa “The Prevalence of Long-term Risperidone-Induced Hyperprolactinemia and its Effect on Sex Hormones and Bone Mineral Density” Lu Chen, Ph.D. University of California, Berkeley “Dissecting the Interaction Between Serotonin System and Glutamate Transmission in Major Depressive Disorder” Qian Chen, Ph.D. University of Chicago “Genetic Studies of the Role of BDNF in the Pathogenesis of Depression” Karl Deisseroth, M.D., Ph.D. Stanford University “Mechanism and Significance of Excitation-Neurogenesis Coupling” Adriana Di Martino, M.D. New York University “Brain Hemoglobin Temporal Dynamic Responses in Children with Autism: A Near Infrared Optical” Xinzhong Dong, Ph.D. Johns Hopkins University “Functional Studies of a Novel Family of Neuropeptide Receptors in the Brain” Jubao Duan, Ph.D. Northwestern University “Functional Characterization of Polymorphisms in Trace Amine Receptor 4 Associated with Schizophrenia” Kevin Duff, Ph.D. University of Iowa “Predicting Cognitive Decline with Lifetime Affective Burden” Steven Duffy, Ph.D. University of Toronto “Regulation of NMDA Receptors, Synaptic Plasticity, and Synaptic Inhibition by D-serine and Neto-1” Sharon Eastwood, D.Phil. University of Oxford “The Developmental Pathogenesis of Schizophrenia: Testing the Subplate Hypothesis” James Christopher Edgar, Ph.D. University of Illinois, Urbana-Champaign “Auditory Gating Deficit: Mechanisms of Neural Synchrony” Haim Einat, Ph.D. University of Minnesota “BCL-2 and Bipolar Disorder: Translating Biochemistry to Behavior” Yuejin (Yueli) Chen, M.D., Ph.D. Simon J. Evans, Ph.D. Vanderbilt University “Anticonvulsant Mood Stabilizers, Antipsychotic Drugs and the Insulin Resistance Syndrome” University of Michigan Medical Center “Fibroblast Growth Factor System Splice Variant Expression in Human Forebrain and Dysregulation in Major Depressive Disorder” Yuncai Chen, Ph.D. University of California, Irvine “Mechanisms of Dendritic Abnormalities in Schizophrenia” Zhe-Yu Chen, M.D., Ph.D. Cornell University “Knock-In Mouse Model for BDNF (Val66Met) Human Polymorphism” Gail L. Daumit, M.D., MHS Johns Hopkins University “Patient Safety for Persons with Severe Mental Illness: Medical Injuries During Hospitalization” Paul B. Fitzgerald, MBBS, MPM, FRANZCP Monash University “A Study of Prefrontal Cortical Plasticity in Schizophrenia” Michael Galsworthy, Ph.D. University of Zurich “Utilizing Innovative Technology to Explore Behavioral and Cognitive Consequences of Chronic Stress and Depression within Naturalistic Housing Settings in the Mouse” Wen-Jun Gao, M.D., Ph.D. Drexel University “Interactions of Dopamine and NMDA Receptors in the Prefrontal Cortex” 49 2006 NARSAD Second-Year Grants Young Investigators David C. Glahn, Ph.D. Steven Kendell, M.D. University of Texas Health Science Center at San Antonio “Neuropsychological and Neuroimaging Abnormalities in Sibling Pairs Discordant for Bipolar Disorders” Yale University “Measurement of Riluzole's Impact Upon Cortical Amino Acid Neurotransmitter Levels in Treatment-Resistant Major Depressive Disorder” Leisa Glantz, Ph.D. University of North Carolina-Chapel Hill “Altered Pyramidal Neuron Architecture in the Prefrontal and Temporal Cortices of Subjects with Depression and Schizophrenia” “Searching for ADHD Genes on Chromosome 15” A. Chistina Grobin, Ph.D. Hiroko Koike, M.D., Ph.D. University of North Carolina-Chapel Hill “GABAA Receptor Modulation of Cortical Interneuron Development” Columbia University “Dysregulation of Dopaminergic Transmission and the Development of 22Q11-Associated Psychiatric Phenotypes” Handan Gunduz-Bruce, M.D. Yale University “GABA-Glutamate Interactions and Psychosis” Amanda E. Guyer, Ph.D. National Institute of Mental Health “Risk for Bipolar Disorder in Preschoolers: A Clinical Neuroscience Study” 50 Jang Woo Kim, M.D. Harvard University Renu Kotwal, M.D. University of Cincinnati “A Pilot Trial of the Efficacy and Safety of Antidepressant Monotherapy for Acute Bipolar Type II Depression vs. Monotherapy with Lithium Carbonate vs. Combination of Lithium Carbonate and Antidepressant: An 8-week Randomized, Double-blind, Clinical Trial” Ashok N. Hegde, Ph.D. Julie A. Kreyenbuhl, Pharm.D., Ph.D. Wake Forest University “RGS4 Reduction and Development of Schizophrenia-like Symptoms” University of Maryland “Adherence to Medications for Type 2 Diabetes Among Patients with Schizophrenia” Christine Marcelle Heim, Ph.D. Emory University “Imaging Neural Substrates of Depression Risk After Childhood Abuse: Processing of Masked Emotional Faces” Jeffrey Henderson, Ph.D. University of Toronto “Role of EphB-Family Receptor Tyrosine Kinases in Regulation NMDA-Mediated Signaling Relevant to Schizophrenia” Christine Hooker, Ph.D. University of California, Berkeley “Neural Mechanisms of Emotion Regulation and Social Functioning in Schizophrenia” Mei Huang, Ph.D. Vanderbilt University “The Important Role of 5HT2C Receptor Antagonism in Atypical Antipsychotic Drug-Induced Dopamine Release in the Medial Prefrontal Cortex” Kristin R. Laurens, Ph.D. University of London “Developmental Correlates of Brain Structure and Function in Children at High-Risk for Schizophrenia” Steven R. Laviolette, Ph.D. University of Western Ontario “Emotional Processing and Learning in an Amygdala to Prefrontal Cortex Functional Circuit: Role of Dopamine and Dopamine Receptor Subtypes” Francis Lee, M.D., Ph.D. Cornell University “Novel Proteins Regulating Neurotrophin Receptor Trafficking” Frank Jangsup Lee, Ph.D. University of Toronto “Dichotomy of Dopamine Transporter Regulation by Dopamine D2 Receptors” Waguih W. IsHak, M.D. Younglim Lee, Ph.D. University of California, Los Angeles “Quality of Life as a Contributor to Response Prediction in Major Depressive Disorder (MDD) in a Natural Clinical Setting” Indiana University “Selective Lesioning of Glia in the Amygdala as a Model of Recurrent Mood Disorders” Lynn L. Johnson, Pharm.D. Weidong Li, M.D., Ph.D. University of Colorado at Denver and Health Sciences Center “The Effects of Cannabis Use in People with Schizophrenia on Clinical, Neuropsychological and Physiological Phenotypes” University of California, Los Angeles “Developmental Studies of DISC-1 Mutations Using an Inducible Model: Impact on Prefrontal and Hippocampal Systems” Roberta M. Kelly, Ph.D. Pesach Lichtenberg, M.D. Salk Institute for Biological Studies “Anatomy of Motor Disturbances that Accompany Mood Disorders” Hebrew University “D-Serine Substitution Monotherapy in Treatment-Resistant Patients with Schizophrenia” 2006 NARSAD Second-Year Grants Young Investigators Wei-Yang Lu, M.D., Ph.D. Jill A. Morris, Ph.D. University of Toronto “Physical Interaction Between Acetylcholinesterase and BetaNeurexin: Implications for Cognitive Deficits in Schizophrenia” Northwestern University “Neurodevelopment, Neuronal Migration and Schizophrenia: Deciphering the Function of DISC-1 (Disrupted in Schizophrenia-1)” Giamal N. Luheshi, Ph.D. Jun Mukai, M.D., Ph.D. McGill University “Maternal Infection and the Role of Cytokines in the Development of Schizophrenia” Columbia University “Impaired Palmitate Modification of Neuronal Proteins and the Psychiatric Phenotypes Associated with 22q11 Microdeletions” Angus W. MacDonald, III, Ph.D. Eleanor Murphy, Ph.D. University of Minnesota “The Genetic and Neural Basis of Paranoia: A Functional MRI Study in Twins” Columbia University “Investigating the Challenges of Recruiting Ethnic Minorities in Genetic Research” Branislav Mancevski, M.D. Karl D. Murray, Ph.D. Columbia University “A Naturalistic Study of Duration of Untreated Psychosis and Neuroleptic Response in Schizophrenia” University of California, Davis “A Screen for Novel Molecular Alterations Associated with Decreased Cortical Inhibitory Function in Schizophrenia” Scott C. Matthews, M.D. Alexander B. Niculescu, M.D., Ph.D. University of California, San Diego “Understanding the Neural Substrates of Autonomic Nervous System Dysfunction in Major Depressive Disorder” Indiana University “Convergent Functional Genomic Studies in Mice Lacking the Clock Gene DBP: A Possible Animal Model of Bipolar Depression” Thomas M. Maynard, Ph.D. Jack B. Nitschke, Ph.D. University of North Carolina-Chapel Hill “Mitochondrial Dysfunction in a Murine Model of Schizophrenia” University of Wisconsin, Madison “Functional Neuroanatomy of Anticipation Abnormalities in Social Anxiety Disorder” Colleen Ann McClung, Ph.D. University of Texas Southwestern Medical Center at Dallas “The Role of NPAS2 in Depression and Anxiety Disorders” David P. Olson, M.D., Ph.D. Steven J. Mee, M.D. Harvard University “Magnetic Resonance Spectroscopy and Metabolite Relaxometry in Major Depressive Disorder” University of California, Irvine “Psychological Pain: A Neglected Core Construct of Mood Disorders and Potential Risk Factor for Suicide-Construction of a Rating Scale” Utrecht University “Common Genomic Variation and its Role in Neuropsychiatric Traits” Roel A. Ophoff, Ph.D. Edward G. Meloni, Ph.D. Guy Orr, M.D. Harvard University “Role of CREB Function in the Bed Nucleus of the Stria Terminals (BNST) in Fear-, Anxiety-, and Depressive-Like Behaviors” Tel Aviv University “Traumatic Brain Injury and Risk for Schizophrenia” Kelly Louise Minor, Ph.D. Harvard University “Neuropsychological Functioning in Bipolar Disorder and Comorbid Substance Abuse” Stanford University “Prevention of Postpartum Depression” Michael J. Ostacher, M.D., MPH Takeo Mizuno, M.D., Ph.D. Iheanyi Julian Osuji, Ph.D. Columbia University “Dopamine Differentially Modulates Medium Spiny Neuron Synapses in the Nucleus Accumbens: Implications for the Pathophysiology of Schizophrenia” University of Texas Southwestern Medical Center at Dallas “Cognition as a Predictor of Treatment Response in Chronically Depressed Patients” Lori Montross, Ph.D. University Hospital of Hamburg “Serotonin Transporter Gene Polymorphism, Depression, Cortisol, and Norepinephrine in 1,024 Patients with Heart Disease: The Heart and Soul Study” University of California, San Diego “Suicide Among Patients with Schizophrenia: A Qualitative Investigation of Risk and Protective Factors” Christian Otte, M.D. Steffen Moritz, Ph.D. Carmine M. Pariante, M.D., MRCPsych University of Hamburg “Confidence in Errors as a Possible Basis for Delusions in Schizophrenia” University of London “Why do Depressed Patients Have Reduced Glucocorticoid Receptor Function In Vitro?” 51 2006 NARSAD Second-Year Grants Young Investigators R. Jeroen Pasterkamp, Ph.D. Mark J. Sergi, Ph.D. Utrecht University “Functionl Proteomics: A Novel Approach to Dissect the Intracellular Signaling Mechanisms that Underlie Neuronal Network Formation” California State University, Northridge “Improving Skill Acquisition in Schizophrenia: Neurocognitive Prediction of Effective Instruction” Tracey Petryshen, Ph.D. Tamim Shaikh, Ph.D. Harvard University “Genetic Mapping and Expression Studies of Mouse Chromosome Substitution Strains to Identify Psychiatric Disorder Genes” University of Pennsylvania “Genomic Rearrangements in Bipolar Disorder” Franck Polleux, Ph.D. University of Miami “Depression and Progression of Congestive Heart Failure — An Examination of Physiological and Psychosocial Pathways” University of North Carolina-Chapel Hill “Role of Calcium Signaling in the Control of the Migration and Neurotransmitter Expression of Cortical Interneurons” Harish C. Prasad, M.D., Ph.D. Vanderbilt University “Functional Genomics of the Human Serotonin Transporter in Mood Disorders” Konasale M. Prasad, M.D. University of Pittsburgh “Molecular Endophenotypes of RGS4 Polymorphisms in FirstEpisode Schizophrenia” Anita Ramani, Ph.D. 52 New York University “Quantitative Magnetization Transfer Imaging in the Early Detection of Schizophrenia” Kerry J. Ressler, M.D., Ph.D. Emory University “The Effects of Hippocampal vs. Amygdala BDNF Deletions on Measures of Emotion” Jeremy Amiel Rosenkranz, Ph.D. University of Texas at Austin “Modulation of Entorhinal Cortex in a Model of Schizophrenia” Biing-Jiun Shen, Ph.D. Martine Simard, Ph.D. Laval University “Longitudinal Neuropsychological Study in Elderly Patients with Very Late-Onset and Early-Onset Schizophrenia Disorders” Arthur A. Simen, M.D., Ph.D. Yale University “Quantitative Trait Mapping a Large Mormon Pedigree with Severe Depression and Anxiety” Helen B. Simpson, M.D., Ph.D. Columbia University “Using Motivational Interviewing to Enhance Treatment Outcome in Obsessive-Compulsive Disorder” Tatiana Sitnikova, Ph.D. Harvard University “Spatiotemporal Imaging of Verbal and Nonverbal Comprehension in Schizophrenia” Patrick D. Skosnik, Ph.D. Indiana University “Visual System Neural Synchronization in Schizotypy and Cannabis Use” Daniel Saal, M.D., Ph.D. Hugh B. Solvason, M.D., Ph.D. Washington State University, Pullman “The Role and Mechanism of Stress Evoked Modulation of Excitatory Synaptic Inputs to the Ventral Tegmental Area” Stanford University “Quantitative Characterization of Insulin Resistance in Patients with Bipolar Disorder Treated with Atypical Antipsychotic Medication: Effect of Treatment with an Oral Hypoglycemic Agent” Kristi A. Sacco, Psy.D. Yale University “Effects of Atomoxetine on Cognitive Function in Schizophrenia” Naoya Sawamura, Ph.D. Iris E.C. Sommer, M.D., Ph.D. Utrecht University “Language Lateralization in Patients with Affective Psychosis, a Comparison to Findings in Schizophrenia” Waseda University “Functional Analysis of Nuclear DISC-1” Ryan Spellecy, Ph.D. Jason Scalia, Ph.D. Medical College of Wisconsin “Stakeholders’ Experiences with Psychiatric Advance Directives” Columbia University “The Neurobiology of Depressive Disorder: Hippocampal Neurogenesis and Serotonin Replacement Therapy” Elizabeth Scarr, Ph.D. University of Melbourne “Muscarinic M1 Receptors in Schizophrenia” Julie K. Staley, Ph.D. Yale University “Antidepressant Mediated Adaptations in Nicotinic Acetylcholine Receptor Expression” John Strauss, M.D., M.Sc. University of Toronto “Association Study of Neuroplasticity Genes in Childhood-Onset Mood Disorders: Beyond the Usual Suspects” 2006 NARSAD Second-Year Grants Young Investigators Irina Strigo, Ph.D. Holly C. Wilcox, Ph.D. University of California, San Diego “Neural Processes of Aversive Stimuli in Patients with Depression” Johns Hopkins University “Offspring of Suicide Decedents Study” Steve Stufflebeam, M.D. Daniel H. Wolf, M.D., Ph.D. Harvard University “Spatiotemporal Mapping of Visual Motion Perception in Schizophrenia” University of Pennsylvania “Hippocampal Dysfunction in Early Schizophrenia” Alina Suris, Ph.D. University of Toronto “Immunological Susceptibility Mechanisms in Schizophrenia” University of Texas Southwestern Medical Center at Dallas “Memory Reconsolidation Interference in PTSD” Karen K. Szumlinski, Ph.D. University of California, Santa Barbara “Homer1 Isoforms in an Animal Model of Psychosis” Takuya Takahashi, M.D., Ph.D. Cold Spring Harbor Laboratory “Synaptic Delivery of AMPA Receptors in the Developmental Barrel Cortex of Rats In Vivo” Tianlai Tang, M.D., Ph.D. Vanderbilt University “Estimating and Reducing the Cardiovascular Risk of Patient with Schizophrenia from Lipid Measures in Ischemic Electrocardio-graphic Changes” Hiroaki Tomita, Ph.D. Tohoku University “Possible Implications of Phospherine Phospatase-Like (PSPHL) Gene in Bipolar Disorder” Timothea Toulopoulou, Ph.D., M.Sc. University of London “Schizophrenia Susceptibility Genes and Cognitive Impairment: Exploring the Extent to Which Phenotypic Co-Variation is Due to a Genetic Overlap” Jason Tregellas, Ph.D. University of Colorado at Denver and Health Sciences Center “fMRI of Auditory Gating in Schizophrenia” Gabriel A. Vargas, M.D., Ph.D. University of California, San Francisco “Identification of an Interaction between the Dopamine D1 Receptor and Niemann-Pick C1 Protein” Jun-Feng Wang, Ph.D. University of Toronto “The Role of Glutathione S-Transferase in Bipolar Disorder and Its Treatment” Jeffrey Welge, Ph.D. University of Cincinnati “Psychometrics and Detection Thresholds for Change on Symptom Severity Scales in Schizophrenia and Mania” Albert Hung Choy Wong, M.D. Ikwunga Wonodi, M.D. University of Maryland “Genetic Polymorphisms of Dopamine Signaling and Smooth Pursuit Eye Movement Dysfunction in Schizophrenia: A Genetic Study of a Schizophrenia Endophenotype” Stephen J. Wood, Ph.D. University of Melbourne “Prefrontal Cortical Function in People at Ultra-High Risk for Psychosis: An fMRI Study of Reflexive Eye Movements” Gouhua Xia, M.D., Ph.D. Case Western Reserve University “A Pilot Study on rTMS for Treatment of Bipolar Depression” Dongrong Xu, Ph.D. Columbia University “A DTI Study of Anatomical Connectivity in Adolescents with Bipolar Disorder” Kavitha Yaddanapudi, Ph.D. Columbia University “Defining Pathogenesis of Autoimmune-Mediated Pediatric Neuropsychiatric Disorders” Hui Zhang, Ph.D. Columbia University “Glutamatergic and Dopaminergic Neurotransmission in AKT1 Null Mice” Zhongming Zhao, Ph.D. Virginia Commonwealth University “A Bioinformatics Approach to Studying Schizophrenia Susceptibility Genes” Chong-Bin Zhu, Ph.D. Vanderbilt University “Phosphorylation and Activation of Serotonin Transporter by p38 MAPK” Lee Zuckerman, Ph.D. Columbia University “Frontal Cortical Regulation of Forebrain Dopamine in a Genetic Mouse Model of Striatal D2 Receptor Overexpression in Schizophrenia” 53 2006 N A R S A D Contributors Research Leaders $100,000 + 54 Anonymous The Attias Family Foundation Sidney R. 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Miller and Ms. Anita Singewald Joseph M. Miller, M.D. Mr. Matthew Miller Ms. Meredith Miller Mr. and Mrs. Michael E. Miller Mr. Stephen A. Miller Mr. and Mrs. William H. Miller, Jr. Mr. and Ms. Lawrence Mills Mr. and Mrs. Peter Mills Ms. Joanne Milobsky Mr. and Mrs. Arthur Mindheim Mr. Jerry Miner and Mrs. Lydia Miner John H. Miner, M.D. Ms. Maureen Mingle Mr. Burton S. Minkoff Ms. Mimi Minkoff Mr. Frederick Minturn Mr. Bill Mitchell Ms. Susan M. Mitchell Mr. and Mrs. William J. Mitchell, Jr. Mr. Alexander Mitrovich Mr. and Mrs. Franklin W. Mixdorf Mr. and Mrs. Allen Moberly Mrs. Sandra W. Mock Mrs. Lillian Modell Ms. Virginia Moffat Mr. and Mrs. Traian C. Moga Mr. and Mrs. Wendell Mohr Mrs. Mary R. Molloy Mr. and Mrs. Peter Molyneux Momouth-Ocean County Chapter of the NJPA Dr. and Mrs. John Monaco Ms. Marie Monsky Ms. Rene Montemayor Mr. and Mrs. John Montgomery Mr. Bill Moore Mr. Donald A. Moore Mr. and Mrs. James E. Moore Lillian S. and Joseph J. 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Mitchell Peters Mr. and Mrs. Alfred Peterson Mr. John Peterson Ms. Marion Peterson Mr. R. D. Peterson Mr. and Mrs. Ernest Petrulio Dr. and Mrs. Norman A. Petti Ms. Mary L. Petty and Mr. Wally Trezise Mr. and Mrs. William R. Pfefferkorn Pfizer Foundation Ms. Ruth H. Phillips Ms. Ruth Phipps Ms. Karen L. Piana Ms. Allene Piazza Mr. Richard Pilbrow Ms. Carol Pinter Piper Jaffray Ms. Pamela Pitchford Dr. and Mrs. Mark I. Pitman Mr. Alan P. Pittman Mr. and Mrs. Leonard Ploener Mr. and Mrs. C. R. Ploger Mr. James Plous Ronald M. Podell, M.D. Ms. Patricia T. Poitras Mr. and Mrs. Eugene Poluha Mr. William W. Porch Mrs. Jeanne S. Porter Mrs. Richard Porter Mr. and Mrs. Morton Porwick Mr. and Mrs. Joel Post Ms. Alison Potts Ms. Peggy J. Potts Mr. Herbert Powell Ms. Laura Powell Mr. Michael Miller and Ms. Marita Powell Mr. and Mrs. Marlowe G. Pranger Mr. Robert L. Pratt Mr. Charles Press Bruce H. 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Stanly Mr. and Mrs. Christopher Stansbury Mr. and Mrs. Paul F. Starck Ms. Marilyn Steele Mrs. and Mr. Maggy Stein Mr. and Mrs. Jack Stein Mr. Michael L. Stein Mr. and Mrs. Steven E. Steiner Mr. and Mrs. George F. Steinfels Mr. Daniel Steinhart Mr. and Mrs. Benjamin Steinman Ms. Nancy R. Steinman Dr. Devora Steinmetz Mrs. Barbara K. Steltz Dr. Giorgio Stendoro Dr. and Mrs. Melvin Stern 2006 N A R S A D Contributors Mrs. Blanche B. Stevens Mrs. Patricia Stevenson Mr. and Mrs. Samuel H. Stevenson Mr. and Mrs. Alan Stewart Mr. and Mrs. William L. Stewart Mr. and Mrs. Jimmy B. Stickland Ms. Patricia L. Stiffler Ms. Katherine A. Stinson Mr. Michael Stoaks Mr. and Mrs. Bernard Stolberg Ms. Joan Stolpen Mr. Todd Stone Ms. Karen Stone-McCown Ms. Laurie Storm Ms. Patricia A. Stover Mr. Robert J. Stracks Mr. and Mrs. Robert Fountaine Mr. and Mrs. Walter Straus Mr. and Mrs. John Strawbridge Mr. Andrew Street Ms. Harriet Streets Mr. and Mrs. Warren Strittmatter Mr. and Mrs. Carl W. Strobel Ms. Kerry G. Stubbs Mr. Frank Su Mr. and Mrs. Michael Sudarsky Dr. Edward Sukoff Mr. Jyotheesh Sukumaran Mr. Timothy C. Sullivan Mr. and Mrs. Edwin Sundell SUPARI Fund Mr. and Mrs. Richard Sussman Mr. Jerry Suter Mr. and Mrs. Russel Suter Mr. and Mrs. Tom A. Suter Ms. Wauneta Suter Ms. LaDonna Sutton Mrs. Valerie Swaisland Mr. and Mrs. Donald L. Swank Ms. Carolyn Swanson Mr. and Mrs. Frank Swanson Ms. Margaret Swanson Mr. and Mrs. Richard Swanson Mr. and Mrs. Cy L. Swartz Mrs. Gene Swiderski Mr. Douglas M. Sykes Mr. and Mrs. Joseph Szubryt Mr. Kevin S. Tait Dr. Maria A. Taliercio Mr. John J. Talley Mr. Bryce G. Tanner Mr. Dhuanne S. Tansill Mr. and Mrs. Herbert A. Tanzer Mr. Ernest Taub Mr. Joseph A. Taylor Margaret C. Taylor, Ph.D. Ms. Margaret H. Taylor and Mr. Vance R. Parker Ms. Nancy E. Taylor Mrs. Marjorie C. Taylor Mr. Ronald Taylor Mr. William R. Taylor Mr. and Mrs. Gerald P. Tchir Mr. and Mrs. Gerard W. Teachman Team Mental Health Services Mr. Norman Teitelbaum Ms. Patricia Telkins Ms. Gladys Telschow Tennessee Valley Recycling, LLC Ms. Shirley Terrell Ms. Mary Thaler The Teagle Foundation Inc. Ms. Alberta Thien Mr. Joshua A. Thoma Mr. Claude S. Thomas Dr. Colin G. Thomas, Jr. Mr. Ernest Thomas Mr. John C. Thomas Dr. Joseph P. Thomas Mr. and Mrs. Ronald A. Thomas Ms. Carolyn Thompson Ms. Glenda Thompson Jess L. Thompson, M.D. Ms. Wawa J. Thorson Mr. James V. Tigani Mr. and Mrs. James R. Tinsley, lll Mr. and Mrs. Howard B. Tisch Mr. and Mrs. Carlos A. Tizon Mr. and Mrs. William Told Mr. and Mrs. Roger Tollefsen Mr. and Mrs. Felix Tomei, III Mr. Henry Tominaga Mrs. Marianne E. Tompkins Ms. Kim M. Torres Dr. Peter M. Torrice Ms. Linda Tosti Dr. and Mrs. Ronald Tosto Mr. Robert W. Touchberry Mr. Robert Towne Mr. and Mrs. David Tozer Mrs. Esther F. Trachtman Mr. and Mrs. Remy W. Trafelet Ms. Carol R. Trager Mr. Philip Tremo Mr. and Mrs. Jack Trentelman Ms. Gloria A. Tressler Mr. and Mrs. Mort Trew Mr. and Mrs. Anthony Troschinetz Mrs. Ilse W. Trumbull Ms. Gail Tsimprea Ms. Charlene Tucker Mr. and Mrs. Charles Tucker Mr. Rick Tucker Ms. Helen Tufaro Ms. Elaine Tullson Ms. Valerie K. Turer Mr. and Mrs. Perry Turgeon Mr. and Mrs. Arthur J. Turner, Jr. Turner Hopkins Fund Ms. Sara Turner Ms. Adele C. Tursone Mr. and Mrs. Donald Tuson Mr. Jacob S. Ulczynski Mr. Heistand S. Underwood Dr. Leslie G. Ungerleider and Mr. Robert Desimone University of Pennsylvania Dept of Psychiatry Mr. Kurt Unkel Ms. Virginia Valentine Ms. Jean H. Vallee Dr. and Mrs. Jose Vallenas Mr. John T. Van Aken Mrs. Clara E. Van Dorn Ms. Marjean L. Van Eman Margaret R. Van Horn, M.D. Ms. Dolphine Van Marcke Mrs. Pamela Van Rensselaer-Long Mr. and Mrs. John R. Van Syckle Mr. and Mrs. John M. Van Zander Ms. Merry S. Vance Ms. Elizabeth R. Vanderhorst Mr. and Mrs. Dale E. Vanderwerff Ms. Barbara Varani Ms. Elizabeth A. Varkoly Mr. James B. Vasile Mrs. Darlene S. Vasi-Williams Ms. Minelba Velez Mrs. Barbara Vella Mr. Scott Velozo Verfaillie's Shoes, Inc. Mrs. Joan Vesper Ms. Carmen R. Victor Mr. Louis Vlahantones Ms. Michele Vodev Ms. Joan K. Vogt Mr. Thomas F. Vogt and Ms. Gwen E. Guglielmi Mr. and Mrs. Thomas T. Volponi Mr. Kurt J. von Boeselager Mr. and Mrs. H. T. Vroom Mrs. Samuel B. Vrooman, III Ms. Marie T. Wackrow Ms. Meredith Waddell and Mr. David Kaplan Mr. Kelly J. Waffle Ms. Dorothy A. Wagner Ms. Elizabeth Wagner Mrs. Joanne Wagner Mr. and Mrs. Louis Wagner Mr. and Mrs. Norman Wain Ms. Elisabeth Waldburger Mr. and Mrs. Bryan L. Walker Mr. and Mrs. John C. Walker Ms. Teresa Walker Ms. Aviva Walker-Sicard Mr. and Mrs. Alexander Wall Ms. Patricia A. Wallace Mr. Sanford Wallenstein Mr. and Mrs. William J. Walls Ms. Ann Walnum Mr. and Mrs. Matt Walsh Mr. and Mrs. Richard L. Walsh Mr. and Mrs. Robert Walsh Ms. Sharron Walter Mr. and Mrs. John S. Walters Ms. Teresa Wang Ms. Lori Warmington Mr. and Mrs. Charles A. Warne Ms. Rita Waterman Mr. John F. Watkins Ms. Anne Waugh Mr. and Mrs. Barry Waxman Ms. Catherine Weaver Mr. and Mrs. William Weaver Mr. Gregory Weber Mr. and Mrs. John W. Weber Ms. Margaret C. Weber Ms. Ruth Weber Mr. and Mrs. Joseph A. Weidner Mr. and Mrs. Kurt Weil Mr. and Mrs. Edward H. Weinberg Mrs. Valerie Weinbrenner Ms. Karen Weiner Mrs. Kathryn E. Weinrich Mr. Kevin J. Weinrich Mr. and Mrs. Laurence Weinstein Mr. and Mrs. Will Weinstein Ms. Janet Weiss Ms. Karen Weiss Mr. and Mrs. Lawrence Weiss Mr. and Mrs. Morry Weiss Rabbi Richard A. Weiss Mr. and Mrs. James Welbourne WELCA Mr. and Mrs. Parker Weld Mr. and Mrs. Philip Wells Mr. John J. Welter Mr. Yi Wen Ms. Linda Werner Mr. Everett Wessner Dr. and Mrs. James D. Westhoven Mr. and Mrs. Harris Weston Mr. and Mrs. Daryl D. Westphalen Mr. and Mrs. Carroll R. Wetzel Richard and Betty Wheaton Mrs. Virginia Whitcombe Mr. Allen White Mr. and Mrs. James R. White Mr. Joseph M. White Mr. and Mrs. Bradford White Mr. Mark White and Ms. Catherine Fitzgibbons Mr. and Mrs. Richard B. White Mr. and Mrs. John R. Whiting Ms. Patricia L. Whitney Mr. and Mrs. Donald K. Whittemore Mr. and Mrs. Jay Wiggins Mr. and Mrs. Christopher S. Wilcox Ms. Cynthia Wiley Mr. and Mrs. Michael Wilhelm Mr. Allan R. Williams Ms. Annie Williams Ms. Kim E. Williams Mr. Myron Williams Mr. Nathaniel E. Williams Mr. and Mrs. Richard E. Williams Mr. Steve Williams Mrs. Edmund Williamson Mr. William Willis Mr. and Mrs. Roger H. Willoughby Ms. Barbara Wilson Mr. Robert C. Wilson Mr. and Mrs. Elliot Winestock Ms. Elaine K. Winik Mrs. Jerri Winston The Herbert and Ruth Winter Foundation Ms. Jo A. Winter Mr. Ingo Winzer Mrs. Mary Ann Wisehart Ms. Patricia T. Wiseman Mr. Peter Wisner Mr. Kyle Witczak Mr. and Mrs. Robert E. Wittes Ms. Sarah Woelfel Mr. Laurence Wohl Mr. Sudhir Wokhlu Mr. and Mrs. Mark L. Wolf Mr. Richard Wolf Ms. Ellen Wolfe Mr. and Mrs. Frank J. Wolfe 65 2006 N A R S A D Contributors Ms. Sydelle Wolfsohn Ms. Susan J. Lamson and Mr. Allan B. Wolfson Ms. Robin Wolfson Mrs. Ruth S. Wolfson Ron K. Wolner, M.D. Mr. and Mrs. Lester Wolosoff Ms. Jan Woltman Mr. and Mrs. Kelvin Womack Ms. Rita Womack Dr. David Wong Deborah H. Wong, Ph.D. Ms. Joy S. Wong Ms. Betty Wood Ms. Carolyn Wood Mrs. Jewell Wood Mr. and Mrs. Robert Woodford Mr. and Mrs. Gary Woodland Mr. and Mrs. Peter Woodruff Mr. Mark Woodson Root Ms. Mary Woolley Mr. Randall J. Wormser Ms. Doris Wortman Ms. Krista L. Wortman Mr. and Mrs. Charles Wright Mr. and Mrs. Clarence Wright Mr. and Mrs. David Wright Ms. Helen Wright Mr. and Mrs. Joseph Wright, Jr. Ms. Susan Wright Wujek-Calcaterra & Sons, Inc. Mrs. Marilyn R. Wyatt Dr. and Mrs. John Wylie Ms. Joanne Yablonsky Joel Yager, M.D. Mr. and Mrs. Edward A. Yakamavage Mr. Mark Yamanaka Mr. and Mrs. Mahmoud Yasin Mr. Jeffrey Yen Ms. Coleen Young Ms. Deborah Young Mr. and Mrs. March Young Ms. Nancy Young Dr. and Mrs. Steven J. Young Mr. and Mrs. Paul A. Yurachek Mr. and Mrs. Andrew L. Zachary Mr. and Mrs. Sidney Zafran Mr. Gerald Zahler Mrs. Maria T. Zamparelli Ms. Judith Zartman Ms. Judith J. Zawojewski Mr. Axel Zdarsky Ms. Linda J. Zecchino Mr. Nicholas Zechmann Ms. Dolly Zeller Mr. and Mrs. Alex Zenker Mr. and Mrs. Benjamin Zenn Ms. Anne M. Zerrien-Lee Ms. Susan J. Zerweck Mr. Ron M. Zettlemoyer Mr. Yunyue Zhu Mr. Mark Ziegenhorn Mr. and Mrs. Robert Ziegler Mr. Melvin Zimmerman and Mrs. Abyna Zimmerman Mr. Philip Zimmerman Mr. and Mrs. William Zimmerman Ms. Susan E. Bach and Dr. Edward J. Zoble Ms. Wendy Zuckerman Ms. and Mr. Ann Zugelter 2006 N A R S A D Honor Tributes 66 Rosalie Alexander Sara Alford-Morrison Brian Anderson Terry Anderson Jasmine Appleberry Edward Arvey Auelta Family Alisa Ball Lynne Barber Neil Barber Judith and Shale Baskin Sue Bass Larry Benenson Hal Bates Jerry Berchin Leslie Berg Ellen Bernstein Maria Betancourt Mary K. Bird Ted Biro Don Bottemiller Larry Brambrut Ruth Brasser Brenda Manuel L. Brodie Barbara Brown Kim Bruning Sylvan Buchman Art Buchwald Bill Burgess Karol Burnham Thomas Burton Irwin Bushman Jeremiah Callaghan Marcia Chavez Scott C. Cline and Family Thomas B. Coles, M.D. Paul Cooks Thomas Davidson Morley Denbo Arvilla Denning Daryl B. Denning Timothy B.Devanney David Dillon Donna Dixon Lloyd Doering Clifford Doyle Jan Durwood Maureen Durwood Albert Dworkin Patricia Ellis Leonard Ente Kaci Fairchild Fran Feigenbaum Karen Feld The Fogel Family Virginia Gates Mark George Rebecca Gerig James E. Gerstner Lauren Green Harvey Greenberg Nancy Greenwood Bill Griffin Patricia Griffin Christine Gurney Dan Haupt Ben Healy Barnett Helzberg L. J. Henman Bob Hess Dan Heyer James Heyer David Hinden Annick Hollister Raymond M. Hood Tom Hood Troy Hood Ross Hoying Anne R.Hudson Kevin Hughes Jerry Jacobs Robert Jaunkalns Nate Jones Andrew Kahn Douglas J. Kaiser Marcia Kaplan Stephen Kastenberg Brooke D. Katz Joel Katz Patrick J. Kelly Howard Kristol Barbara Kuller Jim Kunen John Latta Dr. Leiberman David Levy Ellen Levy Sasha Lickle Constance Lieber Erik Lindstrom Lori Lipman Adelle Locatelli Blogathon Erwin Lurie Christopher M., M.D. Edward Mackie's Mom Clair Manson Kenneth Marcus Paul Margolis Richard Marias Helen S. Mayberg, M.D. James McAnulty Allan McCall Joseph McDonough Peter McNally Marshall & Eric McVadon Mental Health Center Ruth Michelich Richard Missner Jane Novak John P. O'Reardon Herbert Pardes, M.D. Dorothy Peagler Arthur Peck Gail Perzia-Whetstone Lee Peterson Terry and David Pogue Kirsten Rabaut Arthur Radin Christopher Reed Ann Rhode Nick Ridgely Frank Ring Roger Rinn Ira Rose Kelly Roseberry Dr. I. Rosenfeld George Rubin John Rush Phyllis Russal Buzz Savidge Annie Saylor Joseph H. Schaffer Elaine Schirmer Chancey Schmick John Schulze Serenity Center Fred Simpson Tammy Skelton Marvin Slomowitz Cheryl Smith Salwa Smith Samuel Smith Robert Snyder Sam Sokolsky-Tifft Desanka Stipic Jean Stone Judy and Bruce Taylor Family Robert Tominaga Topp Family E. Fuller Torrey Vittorio & Maria Tosti Virginia Toulmin David M.Unger Alexander Van Rensselaer Jo-Ann Weber Sandra Wells Nancy E. Wiley Bruce E. Williams Virginia Wyman Stan & Fern Zimmer 2006 N A R S A D Memorial Tributes Logan Adams Michael A. Adams Carlo A. Adan Affin Robert Alderdice Sebell Alexander Lenore Allbough Helen E. Amatangelo Steven M. Anderson Jasmine Applebury Al Arezzi Frank J. Ascoli Michel Assael Nell Bailey Gregory T. Bak Esther Baker Marianne Banerjee Richard A. Barnett Maria Barretta Edwin Bassett Georgette Battles Harley Bebir Lucia Bedarida Yetta Benson Bill Berdy Elena Berinstein Ben Bernstein Raj Bhangu Bill V. Billingslea James Bistadien Ken Blacic Michael Bland Keith Blanks Dorothy Bock Robert C. Brandt Evan Bromberg Kim Bruning Frederick Buie Eddy Bullingtion Chantal Marie Burke Houston Butler Patrick Butters Charles Cain Dan Calhoun Derek Campbell Donald Campbell Stanley Caplan Erna Carloson Harold Carver Laurence Chalfin Michael Chang Donalda M. Clark Donna Clark Robert Daniel Clifford Lillian Cohen Martin Cohen Mitchell Cohen Sheila Cohen Sean Collins Michael Connolly Richard Cooper Lou Copertino Mickey Corey Julie Curfman William Dailey Winifred Davidson Moody Davis Lawrence DeAngelis Miron Deca Arvilla Denning Angela Deraco Katherine Deschner Geri Di Maio Ruth Dickson Jonathan Dixon Mitchell Doughty Hugh Dowling Edward Doyle Jerry Driskell Joseph Ducate Katherine Dunlap Alan Dutka Mary Eckhardt Hebert Edelstein Robert Edwalds W.. N. Edwards Drew Eggleton Harold Ehrlich Dennis Eiselman Robert Eisen Sheldon Eldridge Robert Elliot Sue Elsberry Robert Elsey Sharon Eppard Beatrice Epstein Richard Ernst Elaine Etlinger Louis Etlinger Jason Evans Thomas Evans Philip Facey Leslie Falzone Laura Fast Francia Feiken Lionel Felzer Wayne Fenton Bernard Ferry Meredith Fick Judy Fimbres Christopher Fiorillo Gertrude Fontaine Graham Frevert Joey Frey Jason Frisco Karen From Aram Gabriel Cicely Garrick Lawrence Gates Joseph Gear Scattie Gentle Anna George T. Edward Giles Ted R. Giles Ira Goldman Nora Goodman Stephen Grabin Bill Graeff Mary Gralnick Stephen Gray William Gray David Green Margery Greenberg Fred Gross Marie Gushurst Craig Hall Nicole Hall Sam Halpern Carlos Ham Jerry Hankins Greg Hanna Pam Hawkins Mark Haygreen James Healy Carl Heinz Earl Heinze Benjamin Hendrickson Raymond Hibbeln Daniel Hinden Eva Hinkley Anna Hirchak-Ebert Richard Hoheb Sophie Holmquist Philip Holzman Enid Horowitz Tad A. Howe Memorial Fund William Howells Jessica Howison Elsie Huber Linda Hug Gregory Humes George Hupkowicz Todd Husted Patricia Hutchings Sharon Hutson Mark Ikenson Watson Ingersoll Betty Isaacs Nyssa Jacobs Dean Jacobsen Arnold Jalef Sabrina James Neal Jameson Alma Jankowsky Jennifer Jarvis Claire Jaskula Jimbo Helen Johnston John Joiner Pamela Jones Kaley Jordan Shelley K. Andrew Kahn Charles Kalvelage Sylvan Kaplan Mike Karbo Morty Kass Jeanne Katz Walter Katz Claude Kaufman Howard Kaufman Mildred Kaufmann Fran Kay Florence Kaye Gertrude Keller Theresa Kelley Aileen Kelly Grant Kendall Michael Kennedy Eileen Kennery Robert Kenney Eric Kertzner Virginia Kesner Dalia Keyser Frances Khoury Mariagrazia Kiggen Norman Kime Cora Kinserlow Kirschner Parents Diana Klingensmith Rhonda Knotts Michael Kopach Joseph and Gene Kraus Fanny Krems Blanche Krinsky Estelle Kulik Norman Lahti Terry Laird Dale Laliberty John Landmesser Gloria Landon Ida Lassow Charles Lauricella Charles C. Lawrence rs. Leader Ray Ledbury Nina Leichter Aunt Lenore Robert Lester Brian James Lewin Jeff Lewis Michael Lewitz Beverly Lieblich Laura Liebman Nathaniel Liebman Patricia Linton Helen Lischner-Call Scott Loeffler Elsie Lord William Lund Mary Lunney Corey Lyding Edmund Lynch Anita MacDonald Scott MacDonald Christopher Mack Edith MacKennan Jerome Mactye Gordon Mader Sylvia Marcus Todd Marcus Paul Margolis 67 2006 N A R S A D Memorial Tributes 68 Anne Marsh Mrs. Martens Earnestine Martens Josephine Mason Lily Matos Luella Mattes Michael Matthews Kellie Matus Tom Matye Travis Matye Dorothy Mayerson Robert C. McClain Rachel Kathleen McClean Anne McDonald J. McDowell Cheryl McKy Carolyn McNamara Jenny McPhee Bert Meadow Megan Meier George Melnyk McCann Melton Ira Mendell Gloria Menken Barbara Merkle David Merlen Steven Messer Mary Meyer Michael Meyers Apphia Michelich Ronald Michelich Lawrence Milinowicz Helene and Louis Miller Hazel Mitchell Phillip Moio Stephen Mole Frances Monaco Amy Moore Manny Morganlander Antonio Morreale Kathryn Moxley Vi Mueller Donna Murphy Brian Musgrave Helen Napolitano Paul Nash William Nelson William C. Normand Daniel Raymond Norsby Gerald Nuznoff Nancy O'Connell Paul O'Leary Vincent Onorato Malamud Ovidiu Carter Owen Arthur Parante Judy Parmet Barbara Parres Grace Patston Theresa Paull Nicole Peal Geoffrey Pease Carli Pervis Michael Peterson Bonnie Picard L. Pickett Gregory Pittner Michael Poirer Lindsay Pollack John Porch Andrew Premo Richard Pritchard Dorothy Proctor Gordon Pscheidt Mickey Putnam Ramez Qureshi Yvonne Rainey Panna Rawal Anthony Razziano Eric Reath Charles Reddy Eleanor Reed Todd Reuling Christine Reuter Amber Reynolds Bessie Reynolds Danielle Richardson Frances Richman Lawrence Roberson Brian Roberts Susan Robinson Jo-Ann Rockwell Sydney Rogut Ruth Roland Christopher Romagnoli Brian Rorick David Rosales Matthew Rosen Matt Rothman Barbara Russell Edna Ryer Irwin Sack Vicent Salvatore Nilda Sanchez Leonard Sandler Donald Sands Clair and Ben Sauls Joseph Schachter Laura Scher Lorene Schnuriger Pearl and Joe Segredo Werner Selo George Seminary Jeffrey Senter Bob Shearer Brian Sheridan Kathy Shovlin Michael Simanoff Mary Simon Thomas Smith Tracey Smith Adam Brian Snell Nancy Snyder Jeanette Soodak Joey Sorbo Joan Sorisio Jimmy Sparks Maragaret Spindell Morton Spool Katherine Stackhouse Alma Starbuck Ann Stebelski Robert Stillmack Ken Stratton Pamela Stubbs Wes Sweetser Dorothy Swerdlow Troy Swink Stephen Tebes Timothy Teigler Nathan Toner James Toscas Sylvia Toth Dorothy Tracy Adam Trott Michael Uris Alex R.Van Rensselaer Eleanor Vekovius Kathleen Vogle Jack Volponi Mary Waddell Po Wen Wang Edward Weaver George Weber Gerri Weber David Weidner Janet A. Weis Harry Weiss Art Weissman Brad Westgate Heidi Westhoven Harold Whisler Thomas C., Whisler Carolyn White Diane White Michael Wieman Aaron Wiezorek Matthew Wilkey Mary Jane Williams Donald Andrew Willis Patricia Willis Richard Wilson Geri Wisebrot Steven Witkop David Witt Michael Woliner Agnes Wood Ryan Woodland Fred Wright Brenda Yianokopolous William Young Peter W. Zartman Ellen Zettlemoyer Gertrude Zurell David Zurlo 2006 N A R S A D Independent Auditors’ Repor t To the Board of Directors of The National Alliance for Research on Schizophrenia and Depression, Inc. and NARSAD Research Institute, Inc. Great Neck, New York We have audited the accompanying combined statement of financial position of The National Alliance for Research on Schizophrenia and Depression, Inc. and NARSAD Research Institute, Inc. (collectively “NARSAD”) as of December 31, 2006, and the related combined statements of activities, functional expenses, and cash flows for the year then ended. These financial statements are the responsibility of the Organization’s management. Our responsibility is to express an opinion on these financial statements based on our audit. We did not audit the financial statements of investment partnerships and investment companies which represent approximately 24% of NARSAD’s total net assets as of December 31, 2006 and approximately 17% of NARSAD’s total revenue for the year then ended. Those statements were audited by other auditors whose reports have been furnished to us, and our opinion, insofar as it relates to the amounts included for the investments in these investment partnerships and invested companies, is based solely on the reports of the other auditors. We conducted our audit in accordance with auditing standards generally accepted in the United States of America. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Organization’s internal control over financial reporting. Accordingly, we express no such opinion. An audit also includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion. In our opinion, the combined financial statements referred to above present fairly, in all material respects, the combined financial position of The National Alliance for Research on Schizophrenia and Depression, Inc. and NARSAD Research Institute, Inc. as of December 31, 2006, and the changes in its net assets and its cash flows for the year then ended, in conformity with accounting principles generally accepted in the United States of America. Information for the year ended December 31, 2005 is presented for comparative purposes only and was extracted from the combined financial statements of National Alliance for Research on Schizophrenia and Depression, Inc. and NARSAD Research Institute, Inc. for that year on which we expressed an unqualified opinion, dated February 10, 2006. February 9, 2007 NARSAD Note: As discussed in Note 2 (i) of the Notes to Combined Financial Statements, extraordinary contributions of $7 million were received in 2005 when the United States government offered unique tax benefits to spur charitable giving. For a complete copy of the audited NARSAD Combined Financial Statements and Supplemental Material please contact the NARSAD office at 800.829.8289 or e-mail: info@narsad.org 69 2006 N A R S A D Financial Statements Combined Statement of Financial Position (with comparative totals for 2005) December 31, 2006 2005 Assets Cash and cash equivalents Investments, at market or fair value (Notes 2 and 3) Due from broker (Note 3) Investment guarantee receivable (Note 3) Contribution receivable Pledges receivable, net (Note 4) Prepaid expenses Assets held in charitable remainder trusts (Note 5) Furniture, fixtures, equipment and proprietary information systems, net (Notes 2 and 7) Security deposits $ 11,019,371 18,802,753 485,393 14,763 1,305,299 11,503 2,620,308 31,452 25,903 $ 34,316,745 $ 14,368,798 16,146,068 31,911 122,822 87,654 1,251,984 9,106 2,563,286 40,995 25,903 $ 34,648,527 Liabilities and Net Assets Liabilities: 70 Accounts payable and accrued expenses Grants payable Accrued compensation Line of credit payable (Note 12) Annuities payable (Note 5) Charitable gift annuities payable (Note 6) Total liabilities Commitments and contingency (Notes 13 and 15) Net Assets: Unrestricted (Note 2) Unrestricted - board designated endowment (Notes 2 and 8) Temporarily restricted (Notes 2 and 9) Permanently restricted (Notes 2 and 11) Total net assets $ 61,785 15,840,334 105,511 2,000,000 1,464,791 524,307 19,996,728 (7,480,022) 12,509,262 2,567,277 6,723,500 14,320,017 $34,316,745 $ 72,469 13,628,073 74,040 2,000,000 1,495,661 457,947 17,728,190 (6,489,866) 12,509,262 4,388,306 6,512,635 16,920,337 $34,648,527 See accompanying notes to combined financial statements. $ - 17,237,423 1,049,060 2,505,500 20,791,983 615,973 1,259,790 1,875,763 22,667,746 (990,156) (6,489,866) $ (7,480,022) 12,509,262 $ 12,509,262 - 57,022 1,432,837 76,239 18,286,483 $ 21,677,590 - $ 717,095 1,230,736 (122,822) Unrestricted UnrestrictedBoard Designated Endowment * All administration and fundraising expenses are funded by specially designated grants. Support and revenue: Contributions (Note 2) Contribution of services (Note 14) Bequests Commitment receivable Net realized and unrealized gains (losses) on investments Net appreciation (depreciation) of assets held in charitable remainder trusts Dividend and interest income Annuities due Net assets released from restrictions (Note 10) Total support and revenue Expenses: Program services: Research grants and awards Scientific advancement Program support Total program services Supporting services: Fundraising* Administration* Total supporting services Total expenses Change in net assets Net assets, beginning of year Net assets, end of year Year Ended December 31, Financial Statements 2006 NARSAD 71 210,865 6,512,635 $ 6,723,500 (1,821,029) 4,388,306 $ 2,567,277 2005 $24,055,542 726,062 834,929 (422,002) 499,716 (12,186) 965,722 91,559 26,739,342 17,401,540 956,002 1,981,470 20,339,012 500,090 987,761 1,487,851 21,826,863 4,912,479 12,007,858 $16,920,337 $15,698,602 766,852 1,441,601 (122,822) 717,095 57,022 1,432,837 76,239 20,067,426 17,237,423 1,049,060 2,505,500 20,791,983 615,973 1,259,790 1,875,763 22,667,746 (2,600,320) 16,920,337 $ 14,320,017 Totals 2006 See accompanying notes to combined financial statements. 210,865 (18,286,483) (1,821,029) 210,865 - $ Permanently restricted - $ 15,698,602 766,852 - Temporarily restricted Combined Statement of Activities (with comparative totals for 2005) 2006 Notes to Combined Financial Statements 1. Nature of the Organization The National Alliance for Research on Schizophrenia and Depression, Inc. (“NARSAD”) is a corporation organized in 1981 under the Commonwealth of Kentucky Not-For-Profit Corporation Act. NARSAD raises and provides funding for scientific research into the causes, treatments, prevention and cures of severe mental illnesses, primarily schizophrenia and depression. In September 1997, NARSAD Research Institute, Inc. (the “Institute”) was organized under Section 501(c)(3) of the New York Not-for-Profit Corporation Law and, therefore, has made no provisions for income taxes in the accompanying financial statements. In addition, the Institute has been determined by the Internal Revenue Service not to be a “private foundation” within the meaning of Section 509(a) of the Internal Revenue Code. All contributions received by the Institute are available to NARSAD for grant distribution. The Institute, an organization affiliated with NARSAD, did not have any activity until 1998. As NARSAD demonstrates both control over and economic interest in the Institute, the accounts of NARSAD and the Institute (collectively “NARSAD”) have been consolidated for presentation in these financial statements. 2. 72 (d) Cash and Cash Equivalents Cash equivalents represent short-term investments with original maturities of three months or less. (e) Investments at Market or Fair Value Investments consist of U.S. government debt securities, REIT Preferred Securities, equities and partnerships. Investments in equity securities with readily determinable market values and investments in debt securities are valued at their fair values in the statement of financial position, based on the last reported sales price on the largest recognized exchange on which they are traded. Income from investments, including unrealized gains and losses, dividends and interest are reported in the statement of activities as change in unrestricted net assets. Investments in partnership interest, without readily determinable market values, are recorded at their fair value, as determined by the general partner. Donated investments are recorded at estimated fair market value on the date of donation. Securities transactions and related income and expenses are recorded on a trade date basis. Summary of Significant Accounting Policies (a) Principles of Combination The accompanying combined financial statements include NARSAD and the Institute, which are related through common board membership, financial control and identical management. Intercompany accounts and transactions have been eliminated in combination. (b) Basis of Presentation The financial statements of NARSAD have been prepared on the accrual basis. In the statement of financial position, assets and liabilities are presented in order of liquidity or conversion to cash and their maturity resulting in the use of cash, respectively. (c) Financial Statement Presentation The classification of a not-for-profit organization’s net assets and its support, revenue and expenses is based on the existence or absence of donor-imposed restrictions. It requires that the amounts for each of three classes of net assets, permanently restricted, temporarily restricted, and unrestricted, be displayed in a statement of financial position and that the amounts of change in each of those classes of net assets be displayed in a statement of activities. (f) Other Than Temporary Impairment of Investments At December 31, 2006 NARSAD deemed that all securities which were in an unrealized loss position were temporarily impaired. Positive evidence considered in reaching NARSAD’s conclusion that the investments were not other than temporarily impaired consisted of: a. There were no specific events which caused concern; b. NARSAD’s ability and intent to retain the investments for a sufficient amount of time to allow an anticipated recovery in value; and c. NARSAD determined that the changes in market value were considered normal in relation to the overall fluctuations in interest rates. (g) Depreciation and Amortization The cost of furniture, fixtures and equipment is depreciated over the estimated useful lives of the assets using the straight-line method. The estimated useful lives of the assets are as follows: Furniture and equipment Proprietary information systems Leasehold improvements 5 years 5 years Lesser of 3 years or term of lease These classes are defined as follows: (i) Permanently Restricted — Net assets resulting from contributions and other inflows of assets whose use by NARSAD is limited by donor-imposed stipulations that neither expire by passage of time nor can be fulfilled or otherwise removed by actions of NARSAD. (ii) Temporarily Restricted — Net assets resulting from contributions and other inflows of assets whose use by NARSAD is limited by donor-imposed stipulations that either expire by passage of time or can be fulfilled and removed by actions of NARSAD pursuant to those stipulations. When such stipulations end or are fulfilled, such temporarily restricted net assets are reclassified to unrestricted net assets and reported in the statement of activities. (iii) Unrestricted — Board Designated Endowment — Net assets not restricted by donor-imposed stipulations but internally restricted by NARSAD for a specific purpose. (iv) Unrestricted — The part of net assets that is neither permanently nor temporarily restricted by donor-imposed (or internally imposed) stipulations. It is NARSAD’s policy to capitalize all fixed asset purchases greater than $1,000. (h) Income Taxes NARSAD was incorporated in the State of Kentucky and is exempt from Federal and state income taxes under Section 501(c)(3) of the Internal Revenue Code and therefore has made no provision for income taxes in the accompanying financial statements. NARSAD has been determined by the Internal Revenue Service not to be a “private foundation” within the meaning of Section 509(a) of the Internal Revenue Code. There was no unrelated business income for 2006. (i) Contributions and Promises to Give Contributions and promises to give are recorded as revenue when either unsolicited cash is received or when donors make a promise to give. Contributions and promises to give are classified as either unrestricted, temporarily restricted, or permanently restricted support. In 2005, three significant donors made extraordinary one-time increased contributions of $7,000,000. 2006 Notes to Combined Financial Statements (j) Use of Estimates In preparing financial statements in conformity with accounting principles generally accepted in the United States of America, management is required to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and revenues and expenses during the reporting period. Actual results could differ from those estimates. As of December 31, 2006, NARSAD has recorded a due from broker in the amount of $485,393 for trades that were unsettled at year end. 4. Unconditional promises to give that are expected to be collected within one year are recorded at their net realizable value. Unconditional promises to give that are expected to be collected in future years are recorded at present value of estimated future cash flows. Conditional promises to give are not included as support until such time as the conditions are substantially met. (k) Functional Allocation of Expenses The cost of providing the various programs and other activities have been summarized on an individual basis in the statement of activities. Accordingly, certain costs have been allocated around the programs and supporting services benefited. Included in pledges receivable are the following unconditional promises to give: (l) Comparative Financial Information The financial statements include certain prior year summarized comparative information. Such information does not include sufficient detail to constitute a presentation in conformity with generally accepted accounting principles. Accordingly, such information should be read in conjunction with the prior year financial statements from which the summarized information was derived. With respect to the statement of activities, the prior year information is not presented by net asset class. With respect to the statement of functional expenses, the prior year functional expenses are presented in total but not by functional classification. December 31, Pledges receivable Discount at 6.00% Net present value of pledges receivable Amounts due in: Less than one year One to five years 5. (m) 3. Effect of Recently Issued Accounting Pronouncements In September 2006, the Financial Accounting Standards Board (“FASB”) issued Statement of Financial Accounting Standards (“SFAS”) No. 157, “Fair Value Measurements”. This standard clarifies the definition of fair value for financial reporting, establishes a framework for measuring fair value and requires additional disclosures about the use of fair value measurements. SFAS No. 157 is effective for financial statements issued for fiscal years beginning after November 15, 2007 and interim periods within those fiscal years. As of December 31, 2006, NARSAD does not believe the adoption of SFAS No. 157 will impact the amounts reported in the financial statements. However, additional disclosures will be required about the inputs used to develop the measurements of fair value and the effect of certain of the measurements reported in the statement of income for a fiscal period. December 31, U.S. government debt securities REIT Preferred securities $ 4,706,497 $ 4,692,079 - 9,172,240 Equities Partnerships - pooled investments * 2,000,000 10,745,775 3,364,899 $15,878,737 $18,802,753 * Cost 2005 Market Value $ 2,888,216 $ 2,776,063 1,776,710 1,947,875 5,744,503 6,599,470 3,439,288 4,822,660 $13,848,717 $16,146,068 One partnership investment is covered by a contribution agreement whereby a contributor personally guarantees that NARSAD’s return will be equal to the invested amount plus interest thereon, compounded at an annual rate of six percent. As of December 31, 2006, there was no amount recorded as a receivable under such agreement. 2005 $1,269,058 (17,074) $1,305,299 $1,251,984 $1,278,344 32,344 $1,310,688 $1,234,529 34,529 $1,269,058 Assets Held in Charitable Remainder Trusts A liability has been recorded for the present value of the future cash flows expected to be paid to the life tenants over their estimated lives. In each taxable year of the trust, the trustee shall pay to the donor during their lifetime, a unitrust amount equal to the lesser of (a) the net income of the trust for the taxable year, or (b) six percent (6%) of the fair market value of the assets of the trust valued as of the first day of each taxable year of the trust (the “valuation date”). Thus, as the market value of the respective trusts fluctuates, so do the annuities payable to the life tenants, less any payments made. As of December 31, 2006, the present value of future payments due to the life tenants amounted to $1,464,791. NARSAD’s investments are summarized as follows: 2006 Market Value 2006 $1,310,688 (5,389) During 1994, two charitable remainder annuity trusts were established naming NARSAD as both trustee of the assets maintained in trust and the recipient of all remainder assets after the death of the respective donors and/or their beneficiaries (the “life tenants”). Each donor put certain assets in trust from which NARSAD, in its role as trustee, remits annuity payments to the life tenants, until such a time that the life tenants are deceased. Upon the death of the life tenants, all principal and income of the trusts will be distributed to NARSAD. As of December 31, 2006, the fair value of net assets held for charitable remainder trusts amounted to $2,620,308. Investments at Fair or Market Value Cost Pledges Receivable, Net 6. Charitable Gift Annuities Under the Charitable Gift Annuity agreement, donors make contributions in exchange for a promise to receive a fixed amount over a specified period of time, usually the life of donor or beneficiary. During the term of the agreement, NARSAD acts as custodian of these funds, whereby the asset and the net present value of the related liability are reflected in the statement of financial position. After the term of the agreement, the remaining assets belong to NARSAD. At December 31, 2006, the Charitable Gift Annuity investment account had a fair market value of $1,315,668 and the related liability amounted to $524,307. 73 2006 Notes to Combined Financial Statements 7. Furniture, Fixtures, Equipment and Proprietary Information Systems, Net Furniture, fixtures, equipment and proprietary information systems, stated at cost, consists of the following: December 31, Furniture and equipment Proprietary information systems Leasehold improvements Total furniture, fixtures, equipment and proprietary information systems Less: Accumulated depreciation and amortization Furniture, fixtures, equipment, and proprietary information systems, net 8. 2006 $244,059 60,500 11,915 2005 $234,091 60,500 11,915 316,474 306,506 (285,022) (265,511) $31,452 $40,995 Unrestricted Board Designated Endowment In 2000, the Board of Directors established an endowment fund for the benefit of NARSAD and the Institute. The use of principal is to be retained for future growth and income may be applied periodically to current projects at the discretion of the Board of Directors. Included in the endowment fund are investments with a cost basis as of December 31, 2006 of $12,509,262. 9. 74 Temporarily Restricted Net Assets Temporarily restricted net assets represent contributions received and certain income related to the following: Research $2,567,277 10. Net Assets Released from Restrictions Temporarily restricted net assets were released from donor restrictions by incurring expenses satisfying the restricted purpose as follows: Research $18,286.483 Mental Illness Research Award Fund The Mental Illness Research Award Fund was established in 1987 from the San Diego Alliance for the Mentally Ill. Investment income earned annually is restricted by the donor for use in research. The funds may be invested, at the discretion of the Finance Committee, in fixed income and equity securities. Administrative Endowment Fund The Administrative Endowment Fund was established in 1988 to fund administrative expenses for support of research in schizophrenia and depression. 12. Line of Credit Payable In 2004, NARSAD established a line of credit with a bank of up to $2,000,000, payable at various interest rate options. At December 31, 2006, $2,000,000 was outstanding on the line of credit. This line of credit was fully repaid January 8, 2007. 13. Concentrations of Credit Risk Financial instruments which potentially subject NARSAD to concentrations of credit risk consist principally of temporary cash investments. NARSAD places its temporary cash investments with high quality financial institutions and, by policy, limits the amount of credit exposure to any one institution. At times, such investments may be in excess of FDIC insurance limits. 14. Volunteer Services In 2006, NARSAD’s Scientific Council contributed services of $766,852, which is reflected in the program support in the combined statement of activities. NARSAD’s Scientific Council consists of a group of scientists who are leaders in neuroscience and psychiatry. These volunteers primarily review research grants and projects on behalf of NARSAD. Additionally, a substantial number of individuals volunteer significant amounts of their time to NARSAD’s fundraising and other activities; the value of these contributed services is excluded since they do not meet criteria for financial statement recognition. 11. Permanently Restricted Net Assets 15. Commitments and Contingency Permanently restricted net assets are comprised of the following: Lease Commitments December 31, 2006 Research Endowment Fund Endowed Research Partnership Program Mental Illness Research Award Fund Administrative Endowment Fund $3,678,465 3,000,000 35,000 10,035 $6,723,500 Research Endowment Fund The Research Endowment Fund was established by donors to accumulate endowments. These funds may be invested, at the discretion of NARSAD’s Finance Committee, in fixed income and equity securities. In accordance with donor restrictions, a portion of the principal, in the amount of $1,000,000, is to remain preserved in this fund until a cure for schizophrenia is found. Investment income is restricted by the donor for use in research. Endowed Research Partnership Program The Endowed Research Partnership Program was established in 2003 to support the Research Partnership Program. NARSAD currently leases office space in Great Neck, New York. The lease calls for a base rent, payment of certain operating expenses and future increases based on the Consumer Price Index. In addition, NARSAD also leases office equipment located in Great Neck, New York. Future minimum rental commitments as of December 31, 2006 are as follows: 2007 $58,817 Rent expense under all operating leases was $174,584 in 2006. Contingency As described in Note 11, NARSAD preserves certain endowments, which, in the event a cure for schizophrenia is found, would be required to be forwarded to organizations either specified by the donor or at the discretion of NARSAD’s Board of Directors. As of December 31, 2006, such endowments amounted to $1,000,000 and are included as permanently restricted net assets in the accompanying statement of financial position. N A RS A D Of ficers and Directors Chairman Hal B. Hollister California Co-Founder, NARSAD Artworks President Constance E. Lieber New York President, Essel Foundation President Emeritus Gwill Newman New Mexico Retired President, Brain Research Foundation, University of Chicago Vice Presidents Joel Gurin New York J. Robert Peterson Florida The Peterson Foundation Jeanne P. Robertson California Chairperson, McLean National Council Secretary Sheila Rabaut, Virginia TREASURER Kiliaen Drackett Van Rensselaer New York Executive Director, National Marketing, Cingular Wireless Matthias B. Bowman New York Private Investor Nella L. Domenici, Esq. New York Carolyn Hamilton Texas President, NAMI Metropolitan Houston Helen S. Hintz New Jersey John B. Hollister California CEO, EEG Spectrum International, Inc. David Maltz Ohio/Florida Maltz Family Foundation Lawrence G. Mohr, Jr. California Founder, Mohr, Davidow Ventures Robert M. Pestronk Michigan Health Officer, Genesee County Director, Genesee County Health Department Liz Robbins New York/District of Columbia President, Liz Robbins Associates Marylou Selo New York President, Werner Alfred Selo Foundation Garen Staglin California Chairman and CEO, eOne Global Jean Stone New York Past President, Mental Health Association of Westchester County Harriet Vicente New York Harriet and Esteban Vicente Foundation Mary Wallace New York Robert S. Warshaw, Esq. New York Trustee, Renate, Hans and Maria Hofmann Trust Trustee, Harriet and Esteban Vicente Foundation Executive Director Stephen G. Doochin New York 75 N A RS A D National Leadership Council NARSAD’s National Leadership Council is a volunteer group bringing the message of new hope through research to communities throughout the United States in private and public gatherings. Chairpersons Edward Arvey Thomas B. Coles, Jr., M.D. Marvin L. Higgins Jean McDaniel Ellen and Howard Schusterman John W. Stackhouse 76 Dr. Sander Abend Amy Alexander Philip P. Ardery Robert Asher and Maureen Schoenbeck Margaret and Allan Atherton Martha and Robert Atherton Bevinn Badenhausen Susan Barenholtz Judy Baskin Barbara and Michael J. Bass Linda L. Bauer Effie D. Beeman Sylvia and P. Bruce Benzler Chris Berrettini Judith and Howard Boasberg Robert O. Boorstin Susan Bourget and Dr. Peter Coles Terrance Brennan Penny Burton Beverly and David Cardwell James I. Crawford The Hon. Susan Crosby Audrey Curtis Connie Donahoe Elaine M. Edwards Nancy and Ralph Everitt Mary Ellen Falk Frederick Findlen, D.M.D Roger Goldman and Stephanie Riven Audrey and Arthur N. Greenberg Lucie Hinden Suzanne and Charles Hoyt Paul Huffman D.J. Jaffe Tom F. Jordan, Jr. Miriam E. Katowitz and Arthur Radin Maria Lewis Kussmaul Mary Kyle Roxanne and Guy Lanquetot Bill Lichtenstein and June Peoples John M. Lizzul Ann and Richard J. Madigan Marlene Mieske and Neal Goldman Dominique Moir Edith Dent Moore Carol and Richard J. Orr Janet Paleo Lucia and S. Giles Payne Dr. Arthur Peck John P. Pfouts Jean and Peppino Puleo Arthur Rand and Sandra Hart Rand Viki Reath M. Bonny Redlich Dr. Henry Sadovsky and Jane Mastro Sadovsky Joyce Schut Carolyn Scripps Dr. Sherman and Ellen Shapiro Lilian Sicular Geoffrey Simon Joyce Tate Sallie and Alex Van Rensselaer Carolyn Wehner Beverly and Kurt Weil Nancy Wilkey Dr. Martin and Nancy Willick Stuart J. Winston Kathy and James N. Zartman N A RS A D Scientific Council President Herbert Pardes, M.D. NewYork-Presbyterian Hospital Vice President Emeritus Floyd E. Bloom, M.D. Scripps Research Institute George K. Aghajanian, M.D. Yale University Huda Akil, Ph.D. University of Michigan Nancy C. Andreasen, M.D., Ph.D. University of Iowa Jay M. Baraban, M.D., Ph.D. The Johns Hopkins University Jack D. Barchas, M.D. Cornell University Samuel H. Barondes, M.D. University of California, San Francisco Francine M. Benes, M.D., Ph.D. Harvard University Wade H. Berrettini, M.D., Ph.D. University of Pennsylvania Randy D. Blakely, Ph.D. Vanderbilt University Pierre Blier, M.D., Ph.D. University of Ottawa Robert W. Buchanan, M.D. University of Maryland Peter F. Buckley, M.D. Medical College of Georgia William E. Bunney, Jr., M.D. University of California, Irvine William F. Byerley, M.D. University of California, San Francisco Marc G. Caron, Ph.D. Duke University William T. Carpenter, Jr., M.D. University of Maryland B.J. Casey, Ph.D. Cornell University Cameron S. Carter, M.D. University of California, Davis Dennis S. Charney, M.D. Mount Sinai School of Medicine Bruce M. Cohen, M.D., Ph.D. Harvard University Jonathan D. Cohen, M.D., Ph.D. Princeton University/University of Pittsburgh Edwin H. Cook, M.D. University of Illinois at Chicago Joseph T. Coyle, M.D. Harvard University J. Raymond DePaulo, Jr., M.D. The Johns Hopkins University Ariel Y. Deutch, Ph.D. Vanderbilt University Wayne C. Drevets, M.D. National Institute of Mental Health Ronald S. Duman, Ph.D. Yale University Jan A. Fawcett, M.D. University of New Mexico Alan Frazer, Ph.D. University of Texas, San Antonio Robert R. Freedman, M.D. University of Colorado at Denver Health Sciences Center J. John Mann, M.D. Columbia University Elliot S. Gershon, M.D. University of Chicago Helen S. Mayberg, M.D. Emory University Mark A. Geyer, Ph.D. University of California, San Diego Robert W. McCarley, M.D. Harvard University Alexander H. Glassman, M.D. Columbia University Bruce S. McEwen, Ph.D. The Rockefeller University Frederick K. Goodwin, M.D. George Washington University Paul R. McHugh, M.D. The Johns Hopkins University Anthony A. Grace, Ph.D. University of Pittsburgh Herbert Y. Meltzer, M.D. Vanderbilt University Paul Greengard, Ph.D. The Rockefeller University Bita Moghaddam, Ph.D. University of Pittsburgh Stephan Heckers, M.D. Vanderbilt University Dennis L. Murphy, M.D. National Institute of Mental Health Rene Hen, Ph.D. Columbia University Charles B. Nemeroff, M.D., Ph.D. Emory University Fritz A. Henn, M.D., Ph.D. Brookhaven National Laboratory Eric J. Nestler, M.D., Ph.D. University of Texas Southwestern Medical Center at Dallas Robert M. A. Hirschfeld, M.D. University of Texas Medical Branch, Galveston Steven M. Paul, M.D. Indiana University Steven E. Hyman, M.D. Harvard University Godfrey Pearlson, M.D. Yale University Robert B. Innis, M.D., Ph.D. National Institute of Mental Health Daniel S. Pine, M.D. National Institute of Mental Health Lewis L. Judd, M.D. University of California, San Diego Michael I. Posner, Ph.D. University of Oregon Peter W. Kalivas, Ph.D. Medical University of South Carolina Robert M. Post, M.D. Pennsylvania State Hospital Eric R. Kandel, M.D. Columbia University Pasko Rakic, M.D., Ph.D. Yale University Richard S.E. Keefe, Ph.D. Duke University Judith L. Rapoport, M.D. National Institute of Mental Health Samuel J. Keith, M.D. University of New Mexico Carolyn B. Robinowitz, M.D. Georgetown University/George Washington University Martin B. Keller, M.D. Brown University Bryan L. Roth, M.D., Ph.D. University of North Carolina, Chapel Hill Kenneth S. Kendler, M.D. Virginia Commonwealth University John L. R. Rubenstein, M.D., Ph.D. University of California, San Francisco James L. Kennedy, M.D. University of Toronto Elaine Sanders-Bush, Ph.D. Vanderbilt University Robert M. Kessler, M.D. Vanderbilt University Alan F. Schatzberg, M.D. Stanford University Kenneth K. Kidd, Ph.D. Yale University Nina R. Schooler, Ph.D. Georgetown University Rachel G. Klein, Ph.D. New York University Philip Seeman, M.D., Ph.D. University of Toronto John H. Krystal, M.D. Yale University Solomon H. Snyder, M.D. The Johns Hopkins University James F. Leckman, M.D. Yale University John S. Strauss, M.D. Yale University Robert H. Lenox, M.D. University of Pennsylvania John A. Talbott, M.D. University of Maryland David A. Lewis, M.D. University of Pittsburgh Carol A. Tamminga, M.D. University of Texas Southwestern Medical Center at Dallas Jeffrey A. Lieberman, M.D. Columbia University Robert C. Malenka, M.D., Ph.D. Stanford University Husseini K. Manji, M.D. National Institute of Mental Health Ming T. Tsuang, M.D., Ph.D. University of California, San Diego Leslie G. Ungerleider, Ph.D. National Institute of Mental Health Nora D. Volkow, M.D. National Institute on Drug Abuse Daniel R. Weinberger, M.D. National Institute of Mental Health 77 “NARSAD is unique because it funds only breakthrough, cutting-edge, innovative research. NARSAD grants enable up-and-coming scientists to gatherpilot data which can then be parlayed into significantly larger grants, and allow more senior investigators to branch out into new and exciting areas…and that’s really extraordinary.” Thomas R. Insel, M.D. Director, National Institute of Mental Health N A R S A D The Mental Health Research Association 60 Cutter Mill Road, Suite 404, Great Neck, NY 11021 516.829.0091 • 800.829.8289 • www.narsad.org