View the latest Feinstein Institute for Medical
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View the latest Feinstein Institute for Medical
FACES OF INNOVATION 2014 – 2015 ANNUAL REPORT TABLE OF CONTENTS The Feinstein Institute for Medical Research is a place where imaginative thinking, innovation and inquiry meet persistence, commitment and collaboration. Here, skilled scientists and researchers work in many disciplines with one goal: to solve unanswered questions about illness and disease and find answers that improve people’s lives. 2 A Message from Michael Dowling............................................................................3 A Message from Kevin J. Tracey, MD........................................................................4 A Message from Barbara Hrbek Zucker...................................................................5 Centers of Excellence...............................................................................................6 Research Directory.................................................................................................20 Board of Directors..................................................................................................35 Financial Summary................................................................................................36 Donors....................................................................................................................37 2015 ANNUAL REPORT A MESSAGE FROM MICHAEL DOWLING I venture to say that no one becomes a doctor without wanting to do the right thing for their patients. Similarly, no one becomes a researcher without believing strongly that they can cure disease. They are both highly motivated, intensely driven individuals who want to make a difference. The magic happens when you can bring the two disciplines together and have them work collaboratively to advance medicine and science. That’s what’s happening at The Feinstein Institute for Medical Research, where scientists and clinical researchers are finding answers to some of the world’s most challenging clinical problems to improve the lives of others. Their discoveries have an impact on individuals’ lives around the world, contributing to new treatments, drugs and equipment. With an international reputation for excellence, the Feinstein Institute has been able to attract the finest talent—scientific professionals who thrive in a supportive environment that encourages investigation, original thought and research. This diverse group of professionals has an equally diverse range of research interests. Recognized by their peers in their respective fields, Feinstein Institute scientists receive funding from the National Institutes of Health and other major institutions, and their findings are published in the most-respected scientific journals in the nation. Their work sparks ideas and contributes to global conversations on important medical issues, ranging from autoimmune disease and bioelectronic medicine to neurological disorders and behavioral health. Thanks to its donors’ generosity, the Feinstein Institute can continue to conduct groundbreaking research, work with partners in the scientific community on research projects, host symposia which explore topics of interests and train tomorrow’s physician-scientists. We are grateful for their support. The North Shore-LIJ Health System is proud of the Feinstein Institute’s staff and their progress in advancing medicine and healthcare. We look forward to the future and to new discoveries which will benefit us all. Michael J. Dowling President and CEO The North Shore-LIJ Health System THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 3 A MESSAGE FROM KEVIN J. TRACEY, MD The Feinstein Institute for Medical Research is an exceptional, internationallyrenowned organization of professionals with a responsibility to innovate and create the future, not wait for it. My colleagues and I prioritize collaboration— teaming with experts throughout the North Shore-LIJ Health System and other notable institutions—to produce knowledge necessary to cure disease. We rely on each other as expert, steadfast, and collegial teammates—knowing that together we will accomplish our goals. 4 The Feinstein Institute produced tremendous achievements in 2014 and 2015. In 2014, Feinstein Institute investigators published new insights into how to treat brain disorders in The Journal of Clinical Investigation, and a discovery of new genes, pathways and cell types involved in inherited susceptibility to rheumatoid arthritis in Nature. Kanti R. Rai, MD, an internationally-renowned leukemia researcher and hematologist, was recognized by the American Society of Hematology with the Society’s highest honor, the 2014 Wallace H. Coulter Award for Lifetime Achievement in Hematology. The Feinstein Institute established collaborations with the University of Notre Dame, Natera, Inc., a leader in non-invasive genetic testing and i360medical Ltd., an Irish medical device innovation company. Also in 2014, the Feinstein Institute established the first Brain Tumor Biotech Center with Voices Against Brain Cancer. Molecular Medicine, our peer-reviewed, open-access journal published its 20th anniversary edition. We announced a strategic affiliation to align the world-class cancer research of Cold Spring Harbor Laboratory with our network of clinical services to accelerate cancer research, diagnosis and treatment. Peter Davies, PhD, head of the Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, received one of the highest honors in neurology, the American Academy of Neurology’s Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases. And we launched an important new strategic initiative to lead the nascent field of bioelectronic medicine, an idea that was featured in the March issue of Scientific American. With the strong foundation established over the past years and the extraordinary researchers here, the Feinstein Institute is ideally and uniquely positioned for growth and continued success. This vision will be put into action with the support of generous donors. So join us and witness firsthand the results of a brilliant collaboration dedicated to the noblest cause. Kevin J. Tracey, MD President and CEO The Feinstein Institute for Medical Research 2015 ANNUAL REPORT A MESSAGE FROM BARBARA HRBEK ZUCKER As the research enterprise of North Shore-LIJ Health System, The Feinstein Institute for Medical Research stands at the threshold of an extraordinary time in medicine. The passion and quest for breakthroughs demonstrated each day by researchers at the Feinstein Institute is exemplified by award-winning achievements and widespread recognition by the scientific community. Working in laboratories and on clinical research programs, our scientists have devoted their lives to making our community a healthier place. They understand, firsthand, the needs of the people we serve and use this knowledge to develop new drugs and treatments. As you can see by the profiles of the outstanding researchers at work at the Feinstein Institute throughout this report, the future is bright with potential. Exemplary achievements, such as the advances we’re leading in bioelectronic medicine, are hallmarks of what we can and will do. The vision is in place, and the researchers are hard at work. Uniquely positioned within the North Shore-LIJ Health System that touches the lives of more than eight million people each year in the most diverse region in the nation, the Feinstein Institute is not only changing the face of medical research, but also the way medicine is delivered. Our culture of excellence and dedication to the treatment of human disease are demonstrated through the advances being made in the Feinstein Institute’s Centers of Excellence, which are highlighted on the pages that follow. Joining us in these vitally important endeavors are our generous donors—individuals, businesses and foundations— who have invested in the Feinstein Institute’s mission. Our committed donors are an essential part of our extraordinary team of physicians, scientists and researchers who enable us to advance science and shape medicine. This is a pivotal time in the evolution of the Feinstein Institute, and philanthropic support from our community is vital to both continue and advance our journey to study and cure disease. As chair of the Board of Directors of the Feinstein Institute, it’s both my pleasure—and honor—to remain a dedicated philanthropic partner of this organization. With your continued support, we will sustain the excellence of the Feinstein Institute now and for years to come. Barbara Hrbek Zucker Chair, Board of Directors The Feinstein Institute for Medical Research THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 5 CENTERS OF EXCELLENCE The Feinstein Institute for Medical Research is the research enterprise of the North Shore-LIJ Health System, and is organized into 13 Centers of Excellence with more than 100 research programs. 6 Feinstein Institute researchers perform and integrate basic and clinical science to discover causes and cures for numerous diseases. They have made groundbreaking discoveries in cancer, Parkinson’s disease, Alzheimer’s disease, lupus, arthritis, sepsis, psychiatric illnesses including schizophrenia and bipolar disorder and many other diseases. 2015 ANNUAL REPORT CENTER FOR ALZHEIMER’S DISEASE & MEMORY DISORDERS The Center for Alzheimer’s Disease & Memory Disorders is the only dedicated Alzheimer’s disease research facility on Long Island. Those in the center are committed to identifying new ways to detect and treat Alzheimer’s disease. This effort is critical not only to our local community, but to the population overall—as a result of the aging population and increased life expectancy, the number of Americans age 65 and older with Alzheimer’s disease may nearly triple by 2050. PETER DAVIES, PHD Head of the Center for Alzheimer’s Disease & Memory Disorders When Dr. Davies was a teenager, his biology class took a field trip to a school for developmentally disabled children. Many of the children suffered from serious brain disorders, which made a huge impression on Dr. Davies at the time. He wanted to understand how the children developed these brain disorders, and when he asked his teacher how he could pursue this, he was advised to study biochemistry. This advice put him on his path to scientific discovery. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 7 CENTER FOR AUTOIMMUNE & MUSCULOSKELETAL DISEASE The immune system is a complex set of cells and tissues that protect the body from invaders such as viruses or bacteria. Sometimes, however, this system goes awry and mistakes our own cells as invaders and repeatedly 8 attacks them—this is called autoimmunity. Researchers in the Center for Autoimmune & Musculoskeletal Disease focus on major types of autoimmune diseases, including arthritis, lupus, hearing disorders, multiple sclerosis, spinal cord injury and disc degeneration. They extensively research the function of risk genes and the mechanisms of tissue injury and develop novel therapies to treat them. 2015 ANNUAL REPORT BETTY DIAMOND, MD Head of the Center for Autoimmune & Musculoskeletal Disease Dr. Diamond’s father, uncle and brother were all interested in history, so she felt influenced to pursue art history. Throughout school, however, she discovered that she was interested in science. Finally, in her senior year of college, she thought What am I going to do with an art history degree? I don’t want to teach. Even though a very competitive career in research wasn’t the easiest path, Dr. Diamond couldn’t ignore her passion for science. From the moment she first learned about lupus in medical school, she knew she wanted to study it and hopefully make a difference in the lives of patients suffering from autoimmune and musculoskeletal diseases. CENTER FOR BIOMEDICAL SCIENCE Researchers in the Center for Biomedical Science discovered that the brain controls the immune system—more specifically, a nerve in the neck signals the release of natural chemicals the body needs to treat disease. The center is pioneering a new field of medicine called bioelectronic medicine, which uses small devices to tell the body to treat itself without manufactured drugs or their side effects. Bioelectronic medicine has the potential to treat a wideranging number of diseases, including arthritis, lupus, obesity, type 2 diabetes, inflammatory bowel disease and even certain cancers. Dr. Tracey, center, in the lab. KEVIN J. TRACEY, MD Head of the Center for Biomedical Science As a neurosurgery resident, Dr. Tracey met an 11-month-old named Janice who arrived in an ambulance with burns covering 75 percent of her body. She was accidently burned by her grandmother who was cooking, tripped and doused Janice with a pot of boiling spaghetti. Janice spent three weeks recovering in the burn unit and eventually stabilized. At the time, Dr. Tracey played with Janice, who was happy, smiling and giggling. The next day, her medical team was shocked to find her dead. There was no medical explanation for her death, Dr. Tracey was haunted by her case and focused his career path toward researching inflammation, which he believed caused Janice’s unexpected death. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 9 CENTER FOR CHRONIC LYMPHOCYTIC LEUKEMIA Those in the Center for Chronic Lymphocytic Leukemia study the activation and maturation of B-lymphocytes, and use this information to develop and test new diagnostics and treatments for patients suffering from chronic 10 lymphocytic leukemia (CLL). CLL is a B-lymphocyte cancer that resides in the blood, bone marrow and lymphoid tissues. It is the most common type of leukemia in adults. It is called “chronic” because it progresses more slowly than other types of leukemia. 2015 ANNUAL REPORT Dr. Chiorazzi, second from left, in the lab NICHOLAS CHIORAZZI, MD Head of the Center for Chronic Lymphocytic Leukemia Dr. Chiorazzi trained at North Shore University Hospital and returned 13 years later as a scientist. It was at this time that he made discoveries in CLL B cells, which compelled Dr. Chiorazzi to turn his focus exclusively to CLL. He and his colleagues in the center have investigated the control of CLL B cell activation, and their findings have significantly impacted the understanding of leukemia cells in patients with CLL. Dr. Chiorazzi continues to conduct research in the hopes of curing the disease. CENTER FOR GENOMICS & HUMAN GENETICS The mission of the Center for Genomics & Human Genetics is to identify and understand the genetic contribution to human diseases and translate these discoveries into new diagnostics and therapeutics. Center researchers are focused on autoimmune diseases and neuropsychiatric traits and disorders, and conduct a full range of human genetics research. PETER K. GREGERSEN, MD Head of the Center for Genomics & Human Genetics When Dr. Gregersen was a medical resident in the late 1970s, a young woman with lupus died under his care and he realized at that moment there was a need to generate knowledge about autoimmune diseases. He then began a rheumatology fellowship at a time when modern molecular biology and genetics were exploding, and he successfully cloned the first HLA genes for rheumatoid arthritis. This convinced him that research was the most important and exciting thing he could do with his life. Today, Dr. Gregersen pursues genetics research with a highly collaborative style, providing him with extraordinary connections and friendships around the world. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 11 CENTER FOR HEART & LUNG RESEARCH The Center for Heart & Lung Research brings together basic and clinical scientists who have an interest in the cardiopulmonary system. A major focus of the Center is the study of pulmonary hypertension, a 12 condition that can occur at any age. Blood vessels in the lungs narrow, causing poor blood flow through the lungs. This results in low oxygen in the blood, pressure in the lungs and a strain on the heart, which eventually causes the heart to fail. The center studies the cardiopulmonary mechanisms that are dysfunctional and their effects on other organs, including the brain. The goal of this research is to prevent or correct the dysfunction to improve quality of life and prevent death. 2015 ANNUAL REPORT Dr. Miller, on the left, in the lab EDMUND J. MILLER, PHD Head of the Center for Heart & Lung Research Dr. Miller started his scientific career in a pathology department, analyzing samples from patients to try to diagnose a disease state. He later joined a research group that studied acute lung injury. He was intrigued and fulfilled by this work and continues to study acute lung injury as well as chronic lung dysfunction. His current interest is in developing a better understanding of the mechanisms involved when the lung does not function properly and the consequences for both the lungs and the rest of the body. To him, the exciting part of research is the development of new ways to treat individuals with lung disease. CENTER FOR IMMUNOLOGY & INFLAMMATION Researchers in the Center for Immunology & Inflammation focus on understanding the basic biological principles of the immune system that protects the body against infections, environmental hazards and internal challenges, and how this system is impaired in disease. They carry out basic, translational, and patient-oriented research on a range of immune and inflammatory disorders, including sepsis, allergy and hypersensitivity, kidney injury, cancer, immune deficiency, HIV infection and conditions affecting maternal, fetal and neonatal health. Their ultimate BARBARA SHERRY, PHD Head of the Center for Immunology & Inflammation Growing up on Long Island, Dr. Sherry never knew a scientist, but she was always interested in science and it was her dream to work in a laboratory. In middle school, she spent a year working on her own research project that won her the school’s top award and gave her the opportunity to describe her research findings to her teachers and fellow students. She loved sharing what she discovered with others. From that moment, she was determined to pursue a career in research. goal is to develop improved treatments and discover cures for these life-threatening conditions. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 13 CENTER FOR MOLECULAR INNOVATION The Center for Molecular Innovation leads the discovery and development of novel therapeutics for human diseases, including lupus, arthritis, diabetes, Alzheimer’s disease and sepsis. It integrates approaches 14 in target discovery with medicinal chemistry to generate small organic compounds and potential drugs. The center has successfully identified several drug candidates and has repurposed existing drugs to target critical proteins involved in neurodegenerative and autoimmune diseases. 2015 ANNUAL REPORT Dr. Al-Abed, center, in the lab YOUSEF AL-ABED, PHD Head of the Center for Molecular Innovation Like most 14-year-olds, Dr. Al-Abed liked to play with his neighborhood friends. One day, he witnessed something that he could not comprehend; his best friend had his first seizure. No one knew what to do. For Dr. Al-Abed, those minutes were the longest of his life. Later, Dr. Al-Abed learned that his friend was diagnosed with epilepsy. He was shocked by how suddenly his friend changed from being just like him to being afflicted with illness. He was consumed with the question of how one day people can be “normal” and then the next day completely changed. This question compelled Dr. Al-Abed to pursue chemistry, science and medicine, inspiring his work to discover new therapies to help patients. CENTER FOR NEUROSCIENCE The mission of the Center for Neuroscience is to shed light on the abnormalities of functional brain organization that underlie nervous system disease. To characterize these networks as biomarkers of disease and treatment, investigators use multimodal brain imaging in conjunction with novel computational methods. Study populations include healthy volunteers and patients with Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, dystonia and Tourette syndrome. DAVID EIDELBERG, MD Head of the Center for Neuroscience Dr. Eidelberg’s post-doctoral training led to a position in a research lab working with PET imaging. He brought PET research to North Shore University Hospital two decades ago. Since that time, he has developed novel imaging techniques that aid in diagnosing and evaluating the progression of Parkinson’s disease. His state-of-the-art PET imaging methods are also used to further understand how current therapies treat Parkinson’s disease. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 15 CENTER FOR ONCOLOGY & CELL BIOLOGY Researchers in the Center for Oncology & Cell Biology study cancer and related aspects of cell biology, all geared toward understanding the abnormal growth and behavior of cells that have been malignantly 16 transformed. These efforts include finding ways to harness the body’s own immune system to attack cancerous growths through antibodies and T cells, approaches that are currently in clinical trials. 2015 ANNUAL REPORT Dr. Rothstein, center, in the lab THOMAS L. ROTHSTEIN, MD, PHD Head of the Center for Oncology & Cell Biology One Saturday morning, at age 12, Dr. Rothstein awoke with severe abdominal pain. After an office examination, he overheard the doctor telling his parents “you know, people still die from ruptured appendices.” As he recovered from surgery, those words rang in Dr. Rothstein’s ears. It was then that he decided to become a doctor so that he could help others. A year later, Dr. Rothstein had his first science class in 7th grade. He was, for the first time, exposed to the world of scientific thinking and was totally captivated. These two experiences put Dr. Rothstein on the track he continues to pursue today—being an MD/PhD physician-scientist, who advances science to improve patients’ lives. CENTER FOR PATIENT-ORIENTED RESEARCH The major goal for investigators in the Center for Patient-Oriented Research is patient-directed research. This includes clinical trials, epidemiology and statistics and focused laboratory science. For example, a team of researchers in the center focuses on the elucidation of the genetics and pathophysiology of DiamondBlackfan anemia (DBA), a rare bone marrow disorder. They work to translate laboratory knowledge into relevant diagnostic and therapeutic tools. Dr. Lipton, on the right, in the lab JEFFREY M. LIPTON, MD, PHD Head of the Center for Patient-Oriented Research As a grade school student, after seeing the Soviet Union launch Sputnik in 1957, Dr. Lipton knew he wanted to be a scientist. But, his fear of heights and poor sense of direction steered him away from aerospace and toward the lab. He obtained his MD and PhD and his long-standing interest in the biology of blood cell production led him to focus on Diamond-Blackfan anemia. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 17 CENTER FOR PSYCHIATRIC NEUROSCIENCE The mission of the Center for Psychiatric Neuroscience is to study behavioral health to identify causes, triggers, markers and treatments for such illnesses as bipolar disorder, schizophrenia and other psychotic disorders. 18 Combining different perspectives in multi-disciplinary research is key to making advances in these illnesses. The Feinstein Institute and the Zucker Hillside Hospital provide valuable platforms to advance such efforts. 2015 ANNUAL REPORT JOHN M. KANE, MD Head of the Center for Psychiatric Neuroscience Dr. Kane has been fascinated by behavior and emotion since he was a child. In medical school, he encountered a patient who suffered from schizophrenia and bizarre delusions. Dr. Kane was intrigued by these dramatic and disabling symptoms, and was even more interested in how medicines available at the time reduced patients’ symptoms. Since that day, Dr. Kane has been dedicated to researching drug discovery and the development of new treatments for schizophrenia. THE CENTER FOR TRANSLATIONAL RESEARCH The Center for Translational Research promotes the identification of therapeutic targets, the development of treatment strategies, and the validation of preclinical studies, leading to commercialized technologies for diagnosing or treating human disease. Through cohesive collaboration, researchers in the center work together and share ideas in hope of advancing biomedical technologies in various research fields. PING WANG, MD Head of the Center for Translational Research Dr. Wang grew up in an industrial city where there was much emphasis on machinery. Being born and raised in this environment, it was natural for him to have a deep interest in figuring out how and why machines worked the way they did. When medicine was introduced to him later in life, he applied his interest in machinery and grew a curiosity to discover how the human body works and what causes disease. Today, Dr. Wang believes that parts of the human body work together to form a beautiful machine that is far more complicated than anything humans have created or even imagined. He works toward the goal of conducting effective and successful laboratory discoveries and translating them into clinical practice for improving patient outcome. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 19 RESEARCH DIRECTORY 20 There are 800 Feinstein Institute investigators and staff who conduct research in immunology, inflammation, neurology, obstetrics/ gynecology, oncology, pediatrics, psychiatry, surgery, urology, genetics and many other specialties. These scientists collaborate with nearly 10,000 physicians across the North Shore-LIJ Health System. Together, they touch the lives of millions of patients each year in the health system’s 19 hospitals, more than 400 outpatient physician practices and a vast network of skilled-nursing home care rehabilitation facilities. The health system’s 2,200-square-mile footprint throughout the New York metropolitan area includes some of the most ethnically-diverse communities in the US, providing an immense opportunity for clinical research faculty and staff who recruit more than 15,000 subjects per year into more than 2,100 studies. Feinstein Institute investigators are internationally-acclaimed authorities in their scientific and medical fields. They win prestigious awards, belong to exclusive scientific and medical honor societies, and are invited worldwide to lecture about their research. Their discoveries are published in the most prestigious scientific and medical journals. The directory to follow highlights select Feinstein Institute investigators organized first by their specialty and then alphabetically by name. * this directory includes researchers who have a Feinstein Institute appointment, are Investigators and/or are on a “scientific track.” 2015 ANNUAL REPORT RESEARCH DIRECTORY Autoimmune Research AUTOIMMUNE & MUSCULOSKELETAL DISEASE Cynthia Aranow, MD Ona E. Bloom, PhD Nadeen Chahine, PhD Anne Davidson, MBBS Betty Diamond, MD Giovanni Franchin, MD, PhD Richard A. Furie, MD Patricio Huerta, PhD Sun Jung Kim, PhD Czeslawa Kowal, PhD Meggan Mackay, MD Frances Santiago-Schwarz, PhD Myoungsun Son, PhD Andrea Vambutas, MD Yong-Rui Zou, PhD BIOMEDICAL SCIENCE Sangeeta S. Chavan, PhD Cliff Deuschman, MD Jared Huston, MD Valentin A. Pavlov, PhD Jesse Roth, MD Kevin J. Tracey, MD Bruce T. Volpe, MD Haichao Wang, PhD Huan Yang, MD, PhD IMMUNOLOGY & INFLAMMATION Vincent R. Bonagura, MD Sleiman Ghorayeb, PhD Christine Metz, PhD Richard J. Schanler, MD Barbara Sherry, PhD Pravin C. Singhal, MD Brain Research ALZHEIMER’S DISEASE & MEMORY DISORDERS Peter Davies, PhD Concepcion Goldberg, MD, PhD Marc L. Gordon, MD Philippe Marambaud, PhD NEUROSCIENCE John Boockvar, MD Stephen L. Dewey, PhD Vijay Dhawan, PhD David Eidelberg, MD Deborah Elkis-Abuhoff, PhD Andrew S. Feigin, MD Chunyan Li, PhD Ashesh Mehta, MD, PhD Michael Schulder, MD Aziz M. Ulug, PhD PSYCHIATRIC NEUROSCIENCE Barbara A. Cornblatt, PhD Christoph U. Correll, MD Juan A. Gallego, MD Terry Goldberg, PhD Vivian Kafantaris, MD John M. Kane, MD Katherine Karlsgodt, PhD Jeremy Koppel, MD Todd Lencz, PhD Anil Malhotra, MD Delbert G. Robinson, MD Keith M. Shafritz, PhD Philip R. Szeszko, PhD Jianping Zhang, MD, PhD Cancer Research CHRONIC LYMPHOCYTIC LEUKEMIA Nicholas Chiorazzi, MD Charles C. Chu, PhD Patricia K.A. Mongini, PhD Kanti R. Rai, MD ONCOLOGY & CELL BIOLOGY Lionel Blanc, PHD Daniel R. Budman, MD Daniel A. Grande, PhD Benchang Guo, PhD Johnson Liu, MD Louis Potters, MD Thomas L. Rothstein, MD, PhD Rosamaria Ruggieri, PhD Sharon Singh, MD Samuel Z. Soffer, MD Bettie M. Steinberg, PhD Marc H. Symons, PhD Sarah Vaiselbuh, MD Genomics & Human Genetics Peter K. Gregersen, MD Annette T. Lee, PhD Heart & Lung Research Harly Greenberg, MD Shu Fang Liu, MD, PhD Edmund Miller, PhD Kaie Ojamaa, PhD Saul R. Powell, PhD Arunabh Talwar, MD Molecular Innovation Yousef Al-Abed, PhD Patient-Oriented Research Louis R. Kavoussi, MD Martin L. Lesser, PhD Jeffrey M. Lipton, MD, PhD Thomas McGinn, MD Jacqueline Moline, MD Raj K. Narayan, MD Renee Pekmezaris, PhD Charles Schleien, MD Robert A. Silverman, MD Henry Simpkins, MD, PhD Adrianna Vlachos, MD Translational Research Max Brenner, MD, PhD Horacio Rilo, MD Ping Wang, MD THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 21 RESEARCH DIRECTORY YOUSEF AL-ABED, PHD CYNTHIA ARANOW, MD LIONEL BLANC, PHD ONA E. BLOOM, PHD Dr. Al-Abed leads the Center of Molecular Innovation, which aims to discover and develop novel therapeutics for human diseases including lupus, arthritis, diabetes, Alzheimer’s disease and sepsis. This research integrates target discovery with medicinal chemistry to generate small organic compounds and potential drugs. Dr. Aranow specializes in lupus and rheumatoid arthritis. She is the clinical director of the Feinstein Institute Center for Clinical Research in Autoimmune Disease and co-director of the Clinical Trials Unit. She conducts studies to better understand and develop treatments for diseases such as lupus and rheumatoid arthritis. Dr. Blanc’s research focuses on developmental erythropoiesis and its impairment in pathological conditions and why genetic disorders in erythroid development trigger a cancer predisposition in children, notably osteogenic sarcoma. The focus of Dr. Bloom’s research is to identify the molecular factors necessary to recover from central nervous system (CNS) injury or disease. Towards that goal, her lab is investigating factors that influence the course of CNS injury or disease, as well as the process to recover from CNS injury or disease. VINCENT R. BONAGURA, MD JOHN BOOCKVAR, MD MAX BRENNER, MD, PHD DANIEL R. BUDMAN, MD Recurrent respiratory papillomatosis (RRP) is a disease caused by the human papillomavirus (HPV)—it is the recurrence of tumors of the upper airway that can lead to airway blockages and suffocation. Dr. Bonagura studies the immune response to HPV to understand why RRP patients do not produce the needed immune response to prevent or control the virus. Dr. Boockvar’s research interests focus on malignant brain tumor formation, treatment and ways to overcome resistance to therapy. In addition to his basic science interests, he currently conducts multiple clinical trials using bloodbrain barrier disruption to deliver high-dose chemotherapy for patients with malignant brain tumors. Dr. Brenner’s research goal is to discover and develop better treatments for patients with autoimmune and inflammatory diseases. Recent areas of focus include rheumatoid arthritis and inflammatory bowel disease. Dr. Budman conducts preclinical, translational and phase I, II and III clinical research in an effort to determine new drug developments for cancer. Molecular Innovation Autoimmune & Musculoskeletal Disease Oncology & Cell Biology Autoimmune & Musculoskeletal Disease 22 Immunology & Inflammation 2015 ANNUAL REPORT Neuroscience Translational Research Oncology & Cell Biology RESEARCH DIRECTORY NADEEN CHAHINE, PHD SANGEETA S. CHAVAN, PHD NICHOLAS CHIORAZZI, MD Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia Dr. Chahine’s research focuses on degeneration and regeneration of musculoskeletal tissues, particularly intervertebral disc, articular cartilage and tendonous tissues. Her lab uses tools of bioengineering, cellular and molecular biology and animal physiology to develop new treatment strategies for repairing arthritic and diseased musculoskeletal tissues. The major focus of Dr. Chavan’s research is in bioelectronic medicine, and developing knowledge about the neuroanatomical pathways and neural codes in the vagus nerve that underlie its regulation of the immune response. She also works to develop targeted therapeutics for the treatment of longterm effects of inflammatory diseases. Dr. Chiorazzi studies the activation and maturation of B-lymphocytes, and uses this information to develop and test new diagnostics and treatments for patients suffering from chronic lymphocytic leukemia (CLL), a B-lymphocyte cancer residing in the blood, bone marrow and lymphoid tissues. His studies have impacted CLL patient prognosis and care. Dr. Chu’s research interests are currently focused on understanding the molecular basis for the development of B cell chronic lymphocytic leukemia (CLL). More broadly, he is interested in B cell biology, particularly B cell maturation and development and its relationship to disease and autoimmunity. Autoimmune & Musculoskeletal Disease Biomedical Science CHARLES C. CHU, PHD 23 BARBARA A. CORNBLATT, PHD CHRISTOPH U. CORRELL, MD Psychiatric Neuroscience Psychiatric Neuroscience Dr. Cornblatt’s research focus is on the early identification and treatment of adolescents and young adults who are considered to be at-risk for developing serious psychiatric illness as adults, especially schizophrenia and other psychotic disorders. She directs the Recognition and Prevention (RAP) program. Dr. Correll researches the identification and treatment of patients with severe psychiatric disorders. His areas of focus include schizophrenia-spectrum, mood-spectrum and aggressive-spectrum disorders. He is also an expert in the risk-benefit evaluation of psychotropic medications. ANNE DAVIDSON, MBBS PETER DAVIES, PHD The current interests of Dr. Davidson are focused on pathogenesis and therapy of lupus. Her lab’s first goal is to understand more about the regulation of autoantibodyproducing B cells and to use newly-discovered pathways of immune activation to design and test novel therapies for lupus. The major goal of Dr. Davies’ research is to improve the understanding of Alzheimer’s disease to allow for the discovery, development and testing of effective therapies. Recent work focuses on activation of cell cycle mechanisms in Alzheimer’s disease and modifications of the microtubule associated protein tau as a reporter for signal transduction in the human brain. Autoimmune & Musculoskeletal Disease Alzheimer’s Disease & Memory Disorders THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH RESEARCH DIRECTORY CLIFF DEUTSCHMAN, MD STEPHEN L. DEWEY, PHD VIJAY DHAWAN, PHD BETTY DIAMOND, MD Dr. Deutschman investigates sepsis. Laboratory work includes determinants of organ dysfunction, with emphasis on mitochondrial dysfunction, aberrant signal transduction and abnormalities of neural and endocrine control mechanisms. Clinical projects focus on epidemiologically based definitions of sepsis. He is also involved in both laboratory and clinical investigations throughout the Department of Pediatrics. Dr. Dewey studies the effects of substance abuse on brain function and structure. He has researched brain exposure to caffeine, tobacco, alcohol, marijuana, cocaine, methamphetamine, opiates, heroin and chemical solvents, and most recently focused on developing a novel treatment for drug abuse. Dr. Dhawan’s research focuses on how biophysics and bioengineering can be applied to neuroscience, and particularly to the study of disease mechanisms in movement disorders and other neurodegenerative conditions. Dr. Diamond studies the induction and pathogenicity of DNA-reactive antibodies in lupus. These studies are designed to provide new strategies to prevent autoimmunity or protect against tissue damage in lupus. She also studies the contribution of maternal antibody to abnormal brain development. DAVID EIDELBERG, MD DEBORAH ELKIS-ABUHOFF, PHD ANDREW S. FEIGIN, MD GIOVANNI FRANCHIN, MD, PHD Dr. Eidelberg directs an imaging research program in brain disease. His program has developed novel imaging techniques to characterize and quantify neural circuits in neurodegenerative disorders and to study their modulation by using functional imaging with PET and fMRI. This approach has provided unique insights into Parkinson’s disease and related movement disorders. Dr. Elkis-Abuhoff’s research interests bring together behavioral medicine and creative/medical art therapy with neuroscience. Her recent research projects connect art therapy with those diagnosed with Parkinson’s disease, cancer and connecting the creative process to neurological responses. Dr. Feigin directs the Laboratory of Experimental Therapeutics for Movement Disorders, which conducts clinical trials of new therapies for Parkinson’s disease, Huntington’s disease and other movement disorders. Dr. Feigin is particularly interested in utilizing PET imaging methods as a biomarker for neurodegenerative disorders in the preclinical phase of illness. Dr. Franchin’s recent focus is on clinical research and patient care. He is interested in lupus and rheumatoid arthritis, and is involved with clinical trials looking at new therapeutic targets for these diseases. He is also investigating the link between metabolism and disease activity in patients with lupus. Biomedical Science Neuroscience Neuroscience Autoimmune & Musculoskeletal Disease 24 Neuroscience 2015 ANNUAL REPORT Neuroscience Neuroscience Autoimmune & Musculoskeletal Disease RESEARCH DIRECTORY RICHARD A. FURIE, MD JUAN A. GALLEGO, MD SLEIMAN GHORAYEB, PHD CONCEPCION GOLDBERG, MD, PHD The goal of Dr. Furie’s research is to investigate the signaling pathways in myeloproliferative diseases —a group of conditions that cause blood cells to grow abnormally in the bone marrow—over the course of the disease. Understanding these mechanisms could allow for the development of more efficacious and bettertargeted therapies. Dr. Gallego’s current research focus is on the role of microRNAs in cerebrospinal fluid and peripheral blood in patients with schizophrenia. Additionally, he is conducting a study using induced pluripotent stem cells derived from first-episode psychosis patients. Dr. Ghorayeb’s research includes diagnostic and therapeutic ultrasound in orthopaedics, dentistry, ophthalmology, urology and obstetrics and gynecology. Projects include assessment of osteoporosis; dental pulp stem cells; penile, testicular and cervical tissue characterization; retinal reattachment; and evaluation of cartilage implanted with preconditioned scaffolds. Dr. Goldberg works to examine RNAs found in the brain using microarray technology. She studies abnormal expression of RNA in tissue from people at high risk or currently suffering from Alzheimer’s disease. She is working to identify novel brain chemicals that can become treatment targets for new drugs. Autoimmune & Musculoskeletal Disease Psychiatric Neuroscience Immunology & Inflammation Alzheimer’s Disease & Memory Disorders 25 TERRY GOLDBERG, PHD Psychiatric Neuroscience Dr. Goldberg is designing the next generation of neurocognitive assessments for patients with psychiatric disease. These tests will be used to diagnose and follow patients over time to see whether the treatments help in improving symptoms. MARC L. GORDON, MD DANIEL A. GRANDE, PHD HARLY GREENBERG, MD The focus of Dr. Gordon’s research is in behavioral neurology and neuropsychiatry. He leads clinical research studies in Alzheimer’s disease, mild cognitive impairment and vascular dementia. His current research involves clinical trials of novel medications, biomarker studies and imaging techniques. Dr. Grande’s research aims to improve treatments for injuries of the musculoskeletal system, including cartilage regeneration and repair, meniscus repair, tendon repair and bone fracture augmentation and fusion. Recent focus has been on developing novel cellmodified scaffolds for enhancing tendon repair and methods to provide gene therapy and tissue-engineered constructs for bone injuries. Dr. Greenberg’s educational and research efforts are in the field of sleep medicine. Recent work has focused on the cardiovascular pathophysiology of sleep apnea and intermittent hypoxia, assessing functional outcomes of sleep apnea therapy and on developing novel diagnostic and screening modalities for sleep-disordered breathing. Alzheimer’s Disease & Memory Disorders Oncology & Cell Biology Heart & Lung Research THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH RESEARCH DIRECTORY PETER K. GREGERSEN, MD BENCHANG GUO, PHD PATRICIO HUERTA, PHD JARED HUSTON, MD Dr. Gregersen conducts international collaboration efforts to achieve a comprehensive genetic description for autoimmune diseases, with a particular focus on lupus and rheumatoid arthritis. He also studies a number of newly defined risk genes for autoimmunity, several of which are potential targets of new drugs. Dr. Guo studies antigeninitiated B cell activation under the influence of T cells. He works to find a dialogue between B cells and T cells in immunity. Dr. Huerta is interested in exploring the interactions between the nervous system and the immune system in health and disease. He currently studies brain abnormalities occurring in lupus and sepsis-induced long-term cognitive deficit, with the goal to isolate key immune and neural mechanisms with the purpose of creating therapies for autoimmunity and brain disorders. The focus of Dr. Huston’s research is to understand how the central nervous system maintains homeostasis and protects against traumatic injury. He is currently studying the beneficial effects of vagus nerve stimulation with the hope that it can improve care of traumatized patients. JOHN M. KANE, MD KATHERINE KARLSGODT, PHD LOUIS R. KAVOUSSI, MD Genomics & Human Genetics Oncology & Cell Biology Autoimmune & Musculoskeletal Disease Biomedical Science 26 VIVIAN KAFANTARIS, MD Psychiatric Neuroscience Dr. Kafantaris’ main research focus is the pharmacological treatment of bipolar disorder and the related area of severe dysregulated aggression associated with conduct disorder or oppositional defiant disorder. She currently studies the neurodevelopmental underpinnings of bipolar disorder and treatment with lithium. 2015 ANNUAL REPORT Psychiatric Neuroscience Dr. Kane’s focus is in the field of schizophrenia research. His work has focused on improving the early diagnosis and treatment of schizophrenia, as well as developing new treatments and treatment strategies to enhance patient long-term effectiveness and quality of life. Psychiatric Neuroscience Dr. Karlsgodt’s research investigates the neural circuitry underlying the executive functions, such as working memory, in individuals with severe psychiatric illness. Her work has incorporated methods such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI) and studies in relevant patient populations such as schizophrenia and bipolar disorder. Patient-Oriented Research Dr. Kavoussi is dedicated to the treatment of urological disease through innovative surgical procedures, diagnostics and medical care. RESEARCH DIRECTORY SUN JUNG KIM, PHD JEREMY KOPPEL, MD CZESLAWA KOWAL, PHD Autoimmune & Musculoskeletal Disease Genomics & Human Genetics The focus of Dr. Kim’s research is to identify regulatory mechanisms of inflammatory function of dendritic cells under both homeostatic and inflammatory conditions. This is with the goal to understand the molecular mechanisms that inhibit the development of autoimmune diseases, particularly in lupus and inflammatory bowel diseases. Dr. Koppel’s research program focuses on elucidating the biology of behavioral disturbances in Alzheimer’s disease and the development of novel treatments. Recent work has focused on the endocannabinoid system in Alzheimer’s disease and the contribution of abnormal tau protein deposition to the development of psychotic symptoms. Dr. Kowal’s research focuses on the mechanisms of the antibody-mediated neuronal abnormalities leading to brain pathology and to hormonal serum alterations in lupus. Projects include the function of the blood-brain barrier in the antibody-mediated pathology of the adult brain and of the maternal antibodymediated abnormalities in the developing brain. Dr. Lee’s current research focus is to discover and validate new biomarkers for early detection, prediction of disease course and outcome and treatment response in cancer, particularly breast and ovarian cancers. Autoimmune & Musculoskeletal Disease Psychiatric Neuroscience ANNETTE T. LEE, PHD 27 TODD LENCZ, PHD Psychiatric Neuroscience Dr. Lencz researches the use of biomarkers, especially novel genetic technologies, to better understand the causes and treatment of schizophrenia. He develops and implements strategies for identifying relationships between genetic variation and psychiatric disease, and examines the role that schizophrenia risk genes play in brain structure, function and development. MARTIN L. LESSER, PHD Patient-Oriented Research Dr. Lesser is a biostatistician and assists investigators in data analysis, research question formulation, study design, data management, storage and retrieval, as well as publication preparation and patient safety and data quality monitoring. CHUNYAN LI, PHD JEFFREY M. LIPTON, MD, PHD Dr. Li’s research is focused on monitoring and treating the injured brain. Projects include developing the next generation brain multimodality monitoring devices using BioMEMS technology, and investigating trigeminal nerve stimulation as a novel therapeutic approach to traumatic brain injury by the activation of endogenous neuroprotective mechanisms. The goal of Dr. Lipton’s research is the elucidation of the genetics and pathophysiology of DiamondBlackfan anemia (DBA), a disorder of the bone marrow. He is working with numerous collaborators to develop genotype-phenotype correlations, resulting in the discovery of a number of DBA genotypes. Neuroscience Patient-Oriented Research THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH RESEARCH DIRECTORY JOHNSON LIU, MD Oncology & Cell Biology Dr. Liu’s research career has focused on the molecular basis of hematopoietic stem cell disorders, collectively referred to as the inherited bone marrow failure syndromes. His current research is aimed at understanding the molecular pathophysiology of Diamond Blackfan anemia and Shwachman-Diamond syndrome. His lab also researches erythropoiesis and sickle cell anemia. SHU FANG LIU, MD, PHD Heart & Lung Research Dr. Liu’s research focus is on molecular mechanisms of septic shock, and septic multiple organ injury. Using modern molecular biology techniques, his goal is to discover the key molecules that can be new targets for developing new therapies. MEGGAN MACKAY, MD Autoimmune & Musculoskeletal Disease Dr. Mackay is a rheumatologist whose primary interests are in lupus, rheumatoid arthritis, scleroderma and vasculitis. She is a co-director of the Clinical Trials Unit and conducts studies to better understand and develop treatments for autoimmune disease. ANIL MALHOTRA, MD Psychiatric Neuroscience Dr. Malhotra works on identifying the biological underpinnings of schizophrenia and determining how antipsychotic drugs work to quell the symptoms of the disease. His group assesses genes and neural circuits associated with increased risk for schizophrenia with the goal of developing more effective treatments. 28 Alzheimer’s Disease & Memory Disorders Patient-Oriented Research THOMAS MCGINN, MD ASHESH MEHTA, MD, PHD Dr. Marambaud’s research focuses on the molecular basis of neuronal degeneration in Alzheimer’s disease and other dementias. His laboratory studies the early biochemical changes leading to the formation of two classic lesions of the Alzheimer’s disease brain: the senile plaques and the neurofibrillary tangles. Dr. McGinn has taught, researched and worked in the area of academic general internal medicine with a focus on providing highquality health care in urban communities. Recent areas of focus include the validation of clinical prediction rules, as well as the prevalence, risk factors and treatment of hepatitis C. Dr. Mehta’s lab uses multiple methods for measuring brain structure and function to advance understanding of human brain function and the treatment of epilepsy. The lab works to improve the diagnosis of epilepsy patients, and better understand the root causes of epilepsy, and the physiological basis of brain structure, function and cognition. PHILIPPE MARAMBAUD, PHD 2015 ANNUAL REPORT Neuroscience CHRISTINE METZ, PHD Immunology & Inflammation Dr. Metz’s research focuses on inflammation in both pregnant and non-pregnant populations and identifying ways to reduce and prevent dysfunctional inflammation. Much of her work centers on endothelial cells, which facilitate the rapid transport of blood and immune cells throughout the body, particularly to sites of infection and inflammation. RESEARCH DIRECTORY EDMUND MILLER, PHD JACQUELINE MOLINE, MD Dr. Miller’s research focuses on lung inflammation and the role of the lung as an inflammatory organ. The studies in his lab involve both acute and chronic disorders that impact the lung. He is closely studying the role of MIF in severe sepsis and pulmonary hypertension. Dr. Moline develops initiatives aimed at promoting and engaging health and wellness, and she oversees a population health and epidemiology research program. Her research interests include World Trade Center health effects, asbestos exposure, occupational lung disorders and heavy metal toxicity. Heart & Lung Research Patient-Oriented Research PATRICIA K.A. MONGINI, PHD Chronic Lymphocytic Leukemia Dr. Mongini’s research focuses on the immune system’s B cells and why B cells sometimes become pathogenic and cause disease. Understanding how to prevent the abnormal development of pathogenic B cells is a critical challenge particularly given the greater emergence of B cell malignancy and certain autoimmune diseases with increased age. RAJ K. NARAYAN, MD Patient-Oriented Research Dr. Narayan’s research aims to develop the next generation of human monitoring devices, with a particular focus on the monitoring of the injured brain. His recent work has focused on the development of a “smart catheter” for the monitoring of multiple physiological parameters simultaneously with a single monitor. 29 KAIE OJAMAA, PHD VALENTIN A. PAVLOV, PHD RENEE PEKMEZARIS, PHD LOUIS POTTERS, MD The goal of Dr. Ojamaa’s research is to understand the causes of heart disease so that novel therapeutics can be developed. She studies inflammation and neurohormones during a heart attack, and why the heart often fails in the long term. In the newborn patient with congenital heart defects, her studies address how increased inflammation may affect neurodevelopment. Dr. Pavlov’s research focuses on the regulation of immune function and inflammation by the nervous system. He studies the role of brain and peripheral neuronal pathways in controlling cytokine responses and inflammation, and the therapeutic efficacy of cholinergic modalities in inflammatory and obesity-driven disorders and cancer-associated immune dysfunction. With an emphasis on the growing population of seniors, Dr. Pekmezaris conducts community-based research investigations with seniors, including telehealth trials for patients living with congestive heart failure, a randomized trial in anemia of chronic disease and a study to predict site of death in end of life patients. Dr. Potters conducts research in prostate cancer, with a focus on prostate brachytherapy techniques and outcomes. He also works on systems and process research for high-quality and safe treatment of innovative care and delivery models. Heart & Lung Research Biomedical Science Patient-Oriented Research Oncology & Cell Biology THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH RESEARCH DIRECTORY SAUL R. POWELL, PHD KANTI R. RAI, MD HORACIO RILO, MD Heart & Lung Research Chronic Lymphocytic Leukemia Translational Research Dr. Powell is involved in cardiac metabolism research and examines the role of the ubiquitin proteasome system in cellular function and malfunction. He conducts ongoing studies that examine altered function of the ubiquitin proteasome system in several diseases. Dr. Rai collaborates in basic and clinical research to conduct a number of experimental drug trials for patients suffering from chronic lymphocytic leukemia (CLL), a cancer that resides in the blood, bone marrow and lymphoid tissues. His studies have impacted CLL patient prognosis and care. Dr. Rilo’s expertise are conducting clinical islet cell transplant for patients suffering from chronic pancreatitis and type 1 diabetes, and performing immunotherapy for pancreatic cancer. His research focuses on mitigating transplant rejection, preservation of donor organs and development of stem cell therapies to treat lifethreatening diseases. JESSE ROTH, MD THOMAS L. ROTHSTEIN, MD, PHD Dr. Roth’s research is focused on obesity and diabetes. Projects include devising earlier ways to diagnose and treat diabetes, understanding how excess body weight brings out diabetes, and uncovering how the microbiome, the microbes in the intestine of the host, influence the host’s food intake and body weight. Dr. Rothstein’s lab aims to clarify the role and function of B lymphocytes in health and disease. His focus is on human B1 cells, a unique B lymphocyte subset that produces “natural” antibody and regulates T-cell activity. Human B1 cells may be important in understanding and treating autoimmune diseases and degenerative diseases of aging. DELBERT G. ROBINSON, MD Psychiatric Neuroscience Dr. Robinson and his firstepisode schizophrenia research network, which includes sites across the country and in Canada, study pharmacotherapy for schizophrenia. The network is currently conducting the RAISE trial, which assesses psychosocial and pharmacological treatments for schizophrenia. 30 Biomedical Science 2015 ANNUAL REPORT Oncology & Cell Biology ROSAMARIA RUGGIERI, PHD FRANCES SANTIAGO-SCHWARZ, PHD Oncology & Cell Biology Dr. Ruggieri researches glioblastoma and medulloblastoma, the most common types of brain tumors in adults and children. She is working on the development of an inhibitor that could provide novel treatments for these types of tumors. Autoimmune & Musculoskeletal Disease Dr. Santiago-Schwarz’s research is concerned with the control of monocyte and dendritic cell development in normal and abnormal physiology as well as developing new therapeutic agents for autoimmune diseases. Current work focuses on disrupted cytokine and immunoreceptor networks affecting monocyte/ dendritic cell activity, particularly in rheumatoid arthritis and lupus. RESEARCH DIRECTORY RICHARD J. SCHANLER, MD CHARLES SCHLEIEN, MD MICHAEL SCHULDER, MD KEITH M. SHAFRITZ, PHD Dr. Schanler researches neonatal nutrition and critical inflammatory disorders of newborns. His nutritional and anti-inflammatory studies aim to provide better outcomes for infants in the neonatal intensive care unit. Dr. Schleien researches cardiopulmonary resuscitation, including brain-blood flow, drug effects, metabolism and mechanics of CPR. Recently, his focus has been in pediatric CPR and hypothermia following cardiac arrest in children. He also has an interest in clinical bioethics in children, as well as other critical care topics. Dr. Schulder investigates new methods of image guidance for neurosurgery, including the incorporation of functional MRI as well as intraoperative MRI. Dr. Shafritz’s research examines the neural and cognitive mechanisms of attention, executive function and emotion. He also studies psychological disorders that involve dysregulation of these processes, such as autism and attention deficit hyperactivity disorder. He works to determine the brain mechanisms underlying behavioral disorders so that future treatments can target those specific brain areas. Immunology & Inflammation Patient-Oriented Research Neuroscience Psychiatric Neuroscience 31 BARBARA SHERRY, PHD ROBERT A. SILVERMAN, MD Dr. Sherry’s research interest is in the mechanisms that coordinate the innate immune response. Her ultimate goal is to gain a better understanding of the molecular mechanisms that regulate chemokine and chemokine receptor responses in healthy individuals, and to identify how these pathways are dysregulated in sepsis, HIV infection and chronic lymphocytic leukemia. Dr. Silverman researches pre-diabetes and diabetes in emergency room patients, as well as the effects of air pollution on asthma-related hospital admissions. He also studies air pollution and cardiac deaths that occur outside of the hospital. Immunology & Inflammation Patient-Oriented Research HENRY SIMPKINS, MD, PHD Patient-Oriented Research Dr. Simpkins uses si/sh RNA knockdown techniques to study the molecular mechanisms of cisplatin resistance that develops in tumor cells. He is studying his area of medicine to create safer, more effective chemotherapies. SHARON SINGH, MD Oncology & Cell Biology Dr. Singh is focused on elucidating the pathways responsible for the cancer predisposition in patients with bone marrow failure syndromes. A recent research focus is on determining the impact of ribosomal protein haploin sufficiency on the immune system. THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH RESEARCH DIRECTORY PRAVIN C. SINGHAL, MD SAMUEL Z. SOFFER, MD MYOUNGSUN SON, PHD BETTIE M. STEINBERG, PHD Dr. Singhal’s research is focused on studying the mechanism of the progression of renal lesions in patients with HIV-associated nephropathy (HIVAN), a complication of AIDS. He also studies the effects of opiates and ethanol on T cell injury. Dr. Soffer studies mechanisms of metastasis and resistance to anti-angiogenic therapies in pediatric soft tissue sarcomas. The goal is to prevent micrometastatic disease following tumor resection in a host of pediatric solid tumors. The research focus of Dr. Son is on a pathogenic pathway in lupus; specifically the fundamental tolerance role of complement C1q in immune system. She studies the function of LAIR-1 and manipulating C1q and LAIR1 for down-regulation of myeloid cells to improve the severity of lupus. Dr. Steinberg’s research is primarily focused on diseases of the airway caused by human papillomaviruses (HPVs). One of these diseases is recurrent respiratory papillomatosis (RRP). She also studies HPV-induced head and neck cancers. MARC H. SYMONS, PHD PHILIP R. SZESZKO, PHD ARUNABH TALWAR, MD KEVIN J. TRACEY, MD Dr. Symons has focused his research on the molecular dissection of signaling pathways that are responsible for tumor cell invasion and survival, with current emphasis on brain tumors. The research focuses on two types of malignant tumors: glioblastoma and medulloblastoma. Dr. Szeszko uses MRI to study the brains of patients who suffer from psychiatric disorders in order to identify structural and functional abnormalities that play a role in the pathogenesis of disorders including schizophrenia, bipolar disorder and obsessivecompulsive disorder. He also identifies neuroimaging predictors of treatment response and outcome. Immunology & Inflammation Oncology & Cell Biology Autoimmune & Musculoskeletal Disease Oncology & Cell Biology 32 Oncology & Cell Biology 2015 ANNUAL REPORT Psychiatric Neuroscience Heart & Lung Research Dr. Talwar studies translational research in pulmonary medicine with a focus on pulmonary hypertension and advanced lung disease. He also researches comorbidities of these diseases and their impact on patients’ mental health and quality of life. Biomedical Science Dr. Tracey’s research focus is inflammation, the physiological and immunological response to infection and injury and the mechanism by which neurons control the immune system. Most recently, he has made discoveries in bioelectronic medicine. Bioelectronic medicine tells nerves to produce the natural chemicals the body uses to cure itself. RESEARCH DIRECTORY AZIZ M. ULUG, PHD Neuroscience Dr. Ulug is experienced in functional applications of MRI, such as functional MRI (fMRI) and MR spectroscopic imaging (MRSI). His research focuses on neuroimaging applications of MR diffusion tensor imaging (DTI). SARAH VAISELBUH, MD ANDREA VAMBUTAS, MD ADRIANNA VLACHOS, MD Dr. Vaiselbuh specializes in histiocytic disorders, pediatric leukemia and lymphoma and her research focuses on stem cell niche biology and the tumor microenvironment. Dr. Vambutas’s research interests are in the restoration of natural hearing in patients with immune-mediated hearing loss who are resistant to conventional corticosteroid therapy. She is currently studying how to prevent further hearing loss and identify new biologic markers in these patients. Dr. Vlachos’s research focuses on inherited bone marrow failure syndromes, particularly Diamond Blackfan anemia (DBA). Her goal is to better understand the epidemiology and biology of this red cell disorder, and ultimately discover better diagnostic and treatment options. Oncology & Cell Biology Autoimmune & Musculoskeletal Disease Patient-Oriented Research 33 BRUCE T. VOLPE, MD HAICHAO WANG, PHD Biomedical Science Translational Research PING WANG, MD HUAN YANG, MD, PHD Dr. Volpe studies recovery after neurological injury with non-invasive technology including interactive robot training and transcranial direct current stimulation (tDCS). His group is also exploring the effect of repetitive trans-cranial magnetic stimulation (rTMS) on brain metabolism using PET technology. The intent of Dr. Wang’s research is to uncover the mechanisms underlying the pathogenesis of inflammatory diseases, including cerebral ischemic injury and sepsis. He is working to identify novel therapeutic targets to fight against severe injury- and infection-elicited dysregulated inflammation. Dr. Wang’s research goal is to develop better therapies to prevent septic onset and progression. He and his team members are studying several potential drug candidates for the treatment of sepsis and other organ injuries including hemorrhagic shock, acute kidney injury, ischemiareperfusion injury, stroke and radiation injury. Dr. Yang studies the immune system and diseases caused by inflammation, with a focus on sepsis. Specifically, she studies the molecular basis of sepsis in order to develop an improved treatment for sepsis. Biomedical Science Biomedical Science THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH RESEARCH DIRECTORY JIANPING ZHANG, MD, PHD YONG-RUI ZOU, PHD Dr. Zhang’s research goal is to improve treatment outcomes of patients with schizophrenia and other psychiatric disorders. Current research is focused on pharmacogenomics of antipsychotic drug response, using genomic markers to predict medication efficacy and side effects. He treats and studies patients with early stages of schizophrenia. Dr. Zou studies hematopoietic stem cell (HSC) function under normal and inflammatory conditions. Another current focus is on how inflammatory factors affect the bone morrow microenvironment and differentiation of stromal cells in lymphoid organs in autoimmune diseases. Psychiatric Neuroscience 34 2015 ANNUAL REPORT Autoimmune & Musculoskeletal Disease BOARD OF DIRECTORS Robert B. Catell Anthony Cerami, PhD Nicholas Chiorazzi, MD Susan B. Claster Steven M. Cohen Thomas J. Degnan, MD Michael A. Epstein Leonard Feinstein Lloyd M. Goldman Susan Karches Curt N. Launer Marjorie Boas Levins Seth Lipsay Nancy A. Marks Charles Merinoff Susan L. Merinoff Edward D. Miller Ralph A. Nappi Peter J. Pappas, Jr Lewis S. Ranieri Jack J. Ross Michael C. Slade Kevin J. Tracey, MD Barbara Hrbek Zucker 35 EX-OFFICIOS Mark L. Claster Michael J. Dowling Laurence A. Kraemer Laura S. Peabody Robert S. Shapiro Bettie M. Steinberg, PhD Andrew C. Yacht, MD THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH FINANCIAL SUMMARY FOR THE YEAR ENDED DECEMBER 31, 2014 (UNAUDITED DOLLARS) Philanthropy and Health System Support $45,583,188 Licensing, Royalties and Other $2,342,043 Total Revenue $92,370,613 36 Grants Revenue $44,445,382 Facilities and Capital Spending $9,246,960 Total Administrative Cost $9,634,144 2015 ANNUAL REPORT Total Expense $92,730,066 Total Research Investment $73,848,962 DONORS H $10,000,000+ n $5,000,000 l $1,000,000 s $500,000 Appliance World of Huntington 2014 Honor Roll The North Shore-LIJ Health System is grateful for the continued support of so many friends. We wish to thank all of our donors whose generosity and ongoing partnership enable us to fulfill our mission of improving the health of the communities we serve. Dr. Brahim Ardolic We make every effort to be accurate and complete in this donor listing. If you have any questions with regard to how your name and/or organization appears, please contact the North Shore-LIJ Health System Foundation at 516-465-2550. Mr. and Mrs. Carlos A. Arredondo The names listed below represent donors, corporations and foundations that have made cumulative gifts of $2,500 or more in 2014. Symbols appearing next to listings reflect lifetime giving. Mr. William Artemenko 57 Bay Street Associates Mr. Greg A. Agran u Lorraine S. Aaron u Ainslie Foundation Aaronson Rappaport Feinstein & Deutsch, LLP u Air Serv Corporation Mr. Arthur A. Abeles Airway Maintenance, LLC Abilene, Inc. Mr. Herbert Aboff Mr. and Mrs. Michael Aboff u Aboff’s Inc. Airline Vending Services, Inc. The Alan T. Brown Foundation to Cure Paralysis Mona Fishman Albert and Andrew Albert s Mr. and Mrs. Richard S. Abramson l Mr. and Mrs. Wayne Albinder Louis & Anne Abrons Foundation Inc. Mr. and Mrs. Michael W. Alderman Mr. and Mrs. William Achenbaum l Mr. and Mrs. John W. Alexander u Mr. and Mrs. Richard H. Ader Mr. Paul R. Ades u The Adikes Family Foundation u Advantage Title Agency, Inc. AdvantageCare Physicians Aeroterm US Inc. AAF AFCO Insurance Premium Finance Affinion Group Aflac Ms. Galina Agapov Mr. Herbert S. Agin and Dr. Denny Agin u $100,000 Alcon Laboratories, Inc. Mr. and Mrs. Michael J. Alesandro u Allergan, Inc. AllianceBernstein Alliance for Lupus Research s Alliance Ground International, LLC Allied Aviation Services, Inc Alonna, LLC Ms. Adelah AlSayer Mr. and Mrs. Charles M. Alter Mr. and Mrs. Philip S. Altheim u Altman Warwick, Inc. American Academy of Dermatology Arizona Beverages USA Arnone, Lowth, Wilson, Leibowitz, Andriano & Greco, Inc. American Academy of Family Physicians Foundation Ms. Elena I. Arredondo Ms. Marisa Arredondo Arthritis Foundation Mr. and Mrs. Russell M. Artzt s ASCAP u Mr. and Mrs. George Asch u American Heart Association u Ms. Margaret M. Ash American Land Services, Inc. Mr. and Mrs. Michael L. Ashner l American Orthopaedic Society for Sports Medicine Assets Recovery Center, LLC American Regent, Inc. Astoria Bank s American Signcrafters Atria Senior Living u The American Society of Hematology u Au Bon Pain Mr. and Mrs. Peter Amoruso Amster, Rothstein & Ebenstein LLP Mr. and Mrs. Albert Anastasi Mr. and Mrs. Arthur A. Anderman s Ms. Christine Anderson-Vietri Angels on the Bay, Inc. u The Anikstein Family u AXA Advisors Mr. and Mrs. Stuart F. Ayre Mr. and Mrs. Henry D. Babcock, Jr. BAE Systems N. Bailey & H. Kirshner Foundation Mr. and Mrs. Morgan Bale Ms. Audrey R. Balog Mr. and Mrs. Thomas M. Bancroft u Annidis Health Systems Corporation Norwood Foundation, Inc. Mr. and Mrs. Douglas Band Anonymous l Banfi Vintners Foundation s Anonymous s Bank of America, N.A. s Anonymous u Jeanine and Merrill Banks u Anonymous Lloyd Staffing Mr. Charles Apelian Mr. and Mrs. Nishan Apelian l Apollo Security, Inc. Dr. and Mrs. Mark E. Astiz BankUnited Ms. Joanne Barbara u THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 37 Barbash Family Fund, Inc. l Ms. Cathy Barbash l Mrs. Lillian Barbash l Mr. Shep Barbash l Ms. Susan Barbash l Harbour Club, LLC Mr. and Mrs. Christopher J. Barber u Mr. and Mrs. Anthony F. Barbiero Barclays Capital Judy and Ron Baron Mr. and Mrs. Manuel H. Barron BWD Group, LLC Mr. and Mrs. Edward Blumenfeld and Family l Mr. Charles Blumenkehl Mr. and Mrs. J. Robert Blumenthal BNP Associates, Inc Mr. and Mrs. Andrew Boas l Dr. and Mrs. Richard S. Boas l Mr. and Mrs. John Bohlsen n Bohlsen Restaurant Group Mr. and Mrs. Stanley F. Barshay u Mr. and Mrs. Geoffrey T. Boisi s Bartlett, McDonough, Bastone & Monaghan, LLP u Dr. and Mrs. Richard J. Bonanno Mr. and Mrs. Joseph Bongiorno Mr. and Mrs. Ralph M. Baruch l ADJO Contracting Corporation Mrs. Sandra Atlas Bass H Mr. David W. Baum u 38 Mr. and Mrs. Roger A. Blumencranz l Mr. and Mrs. Anthony Bonomo l Physicians’ Reciprocal Insurers The Incorporated Village of Bayville Dr. John A. Boockvar Mr. Kevin S. Beiner Boston Scientific Corporation u Dr. Alessandro G. Bellucci Botto Mechanical Corporation Mr. and Mrs. Paul Berger Mr. William Bowles The Sol and Margaret Berger Foundation l Mr. Kevin Boyle Mr. James Bergstrom The Berlin Family Foundation u Brain and Behavior Research Foundation l Mr. and Mrs. Sidney Berman The Brain Aneurysm Foundation u Mr. Martin W. Bernard u Dr. Lenore Brancato and Dr. Louis Potters Mr. Abraham Bernstein Jill and Jay Bernstein Family Foundation u Mr. and Mrs. Frank J. Besignano Bessemer Trust BP Elevator Co. Norbert & Henry Bratt Charitable Trust Mr. E. Steve Braun H Mr. and Mrs. Harry P. Braunstein Mr. and Mrs. Michael Broxmeyer Ms. Rebecca Broxmeyer Mrs. Tracy L. Broxmeyer l Dr. Michael S. Bruno l Estate of Emelda E. Burns u Busch White Norton, LLP Mr. and Mrs. Allen E. Busching u Drs. Annabella Bushra and Peter Abrons Century 21 Associates Foundation Inc. u Century Elevator Maintenance Corporation The Anthony Cerami and Ann Dunne Foundation for World Health l Certilman Balin Adler & Hyman, LLP u Clifford Chance US, LLP Dr. Richard T. Byrnes Dr. Kenneth B. Chapman CA Technologies H Charles H. Thorne, M.D., PLLC Cablevision The Chasanoff Foundation, Inc. l Mr. Joseph R. Cabral Mr. and Mrs. Robert W. Chasanoff l Dr. Jean Cacciabaudo and Dr. William Maiorino Mr. Stanley Chera Mr. Joseph G. Cairo, Jr. The Pat Cairo Family Foundation Inc. u Mr. and Mrs. Salvatore Calcagno Mr. James W. Callanan Cameo Import Inc. Mr. and Mrs. Edward A. Chernoff l MARS Children’s Hospital Foundation Children’s Medical Fund of New York H Children’s Miracle Network Hospitals n Cameron Engineering & Associates, LLP Mr. Richard Chipman u Mr. and Mrs. William J. Candee, III Mr. Andrew Chonoles Ann and Peter Cannell u Chubb & Son, Inc. Jonathan S. Canno and Pierce Roberts Canno s Cigna Health and Life Insurance Company Capell, Barnett, Matalon & Schoenfeld, LLP Cincinnati Children’s Hospital Medical Center Mr. Salvatore Capitano Circulatory Technology, Inc. u Ms. Lucinda M. Cardinal and Mr. Daniel S. Tamkin u Citigroup Mr. and Mrs. Michael G. Caridi u CHIPS Technology Group, LLC Mr. and Mrs. Jerry Clair u Ms. Joan Claster and Mr. Leonard Kaye Dr. Richard Braunstein Carillon Nursing & Rehabilitation Center Brean Capital, LLC Mr. and Mrs. Robert A. Carlstrom u David J. Beyda Memorial Foundation Mr. Fred Brettschneider Laura Louise Breyer Dr. Maria T. Carney and Mr. Joseph M. Carney Ms. Jennifer L. Bickhardt Bridgehampton National Bank Bonnie Cashin Fund CLK Commercial Management Biener Auto Group Inc. Bridgehampton Stone, Inc. CLL Global Research Foundation u Carl Vincent Bini Memorial Fund Bridgewater Associates, LP Dr. Miriam Caslow and Mr. Robert J. Caslow Club House Italia of USA LLC Biomedical Research Models, Inc. Dr. Derek Brinster Mr. and Mrs. Frank Castagna l CNA Foundation Bio-Reference Laboratories u Brock Solutions Mr. and Mrs. O. F. Biondi Jr. Mr. and Mrs. Bert E. Brodsky u Biotronik, Inc Mr. and Mrs. Chester F. Broman Dr. Fabien D. Bitan Mr. and Mrs. Robert Brooks Mr. and Mrs. Leon Black u Mr. and Mrs. Dayton T. Brown, Jr. l Ms. Elise M. Bloom and Mr. Gregory I. Rasin The William Brown Foundation, Inc. u Bloomingdale’s u Mr. Daniel H. Broxmeyer Mr. Eric S. Blumencranz s Mr. Evan Broxmeyer Bestcare, Inc. Bethpage Federal Credit Union BWD Group, LLC 2015 ANNUAL REPORT Estate of Mark Broxmeyer l F ifth Avenue of L.I. Realty Associates Mr. and Mrs. Robert F. Castano Mr. Peter Castle Mr. Frederick Catanese Mr. and Mrs. Robert B. Catell s Ms. Colleen Cavaliere Centennial Elevator Industries, Inc. Central General Medical & Dental Staff u Mr. and Mrs. Mark L. Claster n Carl Marks Foundation, Inc. The Clinton Family Foundation Estate of Arthur G. Cohen Mr. and Mrs. Edward M. Cohen Hiram Cohen & Son, Inc. Mr. and Mrs. Jonathan Cohen Mr. and Mrs. Michael S. Cohen Mr. and Mrs. Ronald Cohen Ms. Sharon J. Cohen l Mr. and Mrs. Steven A. Cohen H Mr. and Mrs. Steven M. Cohen and Mrs. Bernice Cohen l H $10,000,000+ Mr. and Mrs. Maurice J. Cohn l Damaghi Families l n $5,000,000 l $1,000,000 s $500,000 Douglas Elliman Real Estate u Epilepsy Foundation Max B. Cohn Family Foundation Farahnaz and Babak Damaghi Mr. and Mrs. Michael J. Dowling Epilepsy Study Consortium, Inc. Mr. Seymour Cohn Haleh and Kambiz Damaghi Robert N. and Nancy A. Downey l Sol Cohn Foundation Mitra and Nader Damaghi Mr. Damien Drab Mr. Michael Epstein and Ms. Lisa Martin Epstein l Estate of Louise Colavito Shahnaz and Nasser Damaghi Mr. and Mrs. Daniel J. Driscoll Cold Spring Hills Center for Nursing & Rehabilitation Morris & Rose Danzig Charitable Trust u Mr. and Mrs. Michael J. Driscoll Ms. Karen Coleman Mr. and Mrs. Philippe P. Dauman u Mr. and Mrs. John K. Colgate, Jr. s David Lerner Associates u Duenas Trucking Simon & Eve Colin Foundation, Inc. u Mr. Robert G. Davidoff Colliers International LI Inc. Ms. Katherine M. Davis Compass Group, North America Computershare Trust Company of Canada Estate of Irwin Davis l Mr. and Mrs. Lawrence S. Davis l Davis Vision Mrs. Ruth A. Drucker u Dr. and Mrs. Neal F. Epstein Mrs. Phyllis Epstein Mr. and Mrs. Scott Erlich Essig Electrical Services, Inc. The Estee Lauder Companies Inc. s Duffner & Voigt Inc. The Norma Duncan Testamentary Trust Etchepare Family Foundation Dunkin Donuts/Baskin Robbins Foundation Mr. and Mrs. Bernard Ettinger u Mr. Thomas Durkin Extended Nursing Personnel, CHHA u Evercore Trust Company Ms. Alyssa Davner E.I.B. LMCC Fund Mr. and Mrs. Francois X. de Mallmann Eagle Capital Management, LLC Henry M. Ebbitt Trust Eye Care Centers of America, Inc. The De Rosa Foundation for Colon Cancer Research and Prevention u Paul R. Eckna Memorial Foundation EZE Software Group Mr. Michael P. Contillo F.A.C.T. Long Island Foundation Mr. and Mrs. Robert F. Castano Mrs. Vincent de Roulet l Fache Industries, Inc. Mrs. Alison Conyngham Neisloss Ira W. DeCamp Foundation u Dr. David R. Edelstein and Ms. Eve Lesser DeCorato Cohen Sheehan & Federico u Edgewood Management, LLC The Eger Foundation Mr. and Mrs. Peter M. Fahey u Degmor, Inc. Mr. and Mrs. David Einbinder u Fan Fox and Leslie R. Samuels Foundation, Inc. l DEI Incorporated Dr. and Mrs. Mark B. Eisenberg Farrell Fritz, P.C. Peter & Jeri Dejana Family Foundation u Mr. and Mrs. Martin Eisenberg Ms. Cara Faske Mr. and Mrs. Claudio Del Vecchio Mr. and Mrs. Ronald Eisenberg FBR Capital Markets & Company Mr. and Mrs. Saul Eisenberg u Foundation of the American College of Allergy, Asthma & Immunology Mr. Michael Condran Mr. Dennis Connors Mr. Thomas Constance Conyngham Foundation Agency Frederic W. Cook & Co., Inc. Mr. Jonathan D. Cooper Spectronics Corporation Mr. and Mrs. John Corrado The Corso Family Foundation - Care of Joseph Corso Mr. and Mrs. Konstantine Costalas Dr. and Mrs. Peter D. Costantino Costco Wholesale l Ms. Eileen V. Costello The Craigmyle Foundation s Cravath, Swaine & Moore LLP Dr. and Mrs. James M. Crawford Credit Union Miracle Day, Inc. Mr. and Mrs. Peter O. Crisp n Mr. and Mrs. Brad Cronin Ellen and Daniel Crown l Deloitte & Touche LLP Delta Air Lines u Dr. and Mrs. Louis DeLuca Mr. and Mrs. Manfred E. Demenus Dentons Department of Pediatrics, SIUH Mr. and Mrs. Thomas E. Dewey, Jr. s Dr. Kush Dholakia Diamond Blackfan Anemia Foundation Dr. Eric S. Cruzen The DiBenedetto Family Foundation Ms. Josephine Cupo DiFazio Power & Electric, LLC Michele and James Cusack Mr. and Mrs. Jack DiMaio Drs. Patricia and Fred Cushner Mr. Joseph DiMartino u Cystic Fibrosis Foundation u Dime Savings Bank of Williamsburgh D & D Elevator Maintenance, Inc. Drs. Catherine A. D’AgostinoBarakat and Richard R. Barakat Dr. Michael Y. Divon u Donaldson Interiors, Inc. Dr. John D’Angelo Mr. and Mrs. Thomas E. Dooley l Mr. and Mrs. Joseph F. D’Angelo u Mr. and Mrs. Lawrence Doppelt u DAL Global Services, LLC Barbara Dorsch Foundation Jillian E. Daly Foundation u Mr. and Mrs. John C. Doscas u $100,000 The Charles L. Read Foundation Mr. and Mrs. Warren Eisenberg u Eisenhardt Mills, Inc. ExxonMobil Foundation Faegre Baker Daniels, LLP Mr. and Mrs. Robert Feidelson Mr. and Mrs. Adam Elberg The Louis and Gertrude Feil Family H Mr. Christopher Eler Mr. David H. Feinberg Mr. Martin Elias l Mr. and Mrs. Frank Feinberg H Ike, Molly & Steven Elias Foundation Mr. and Mrs. Herbert Feinberg u Ms. Theresa Elkowitz Drs. Sheryl and Randall Feingold Dr. Marty Ellington Ms. Amy Feinstein u Thomas and Jeanne Elmezzi Private Foundation H Mr. and Mrs. Jeffrey L. Feinstein u Emergency Medicine Services of SI, PC u Mr. and Mrs. Richard S. Feinstein u Mr. and Mrs. Leonard Feinstein H Empire Office Equipment Mr. and Mrs. Michael E. Feldman u Endometriosis Foundation of America, Inc. u Ms. Ann Feldstein Mr. and Mrs. Marshall Felenstein u Mr. and Mrs. Peter Engel Mrs. Amy Feller Mr. and Mrs. Daniel Englander u Mr. and Mrs. Larry Fenster Mr. and Mrs. Israel Englander l Mr. and Mrs. Anthony C. Ferreri u Mr. Charles Entenmann u Mr. and Mrs. Christopher C. Ferreri Mr. Robert Entenmann Mr. and Mrs. Joseph Ferreri Family of William Entenmann Mr. and Mrs. Fredric Fetkowitz Entertainment Industry Foundation Ficalora Family Foundation u THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 39 Dr. and Mrs. David H. Fields u Dr. and Mrs. Noah S. Finkel Mr. and Mrs. David S. Finkelstein Friends of Maya Chang, Inc. Joel Finkelstein Cancer Foundation H Mr. Scott Frishman u Mr. and Mrs. Brian Finn u Mr. Glen Froio First Presbyterian Church The Clothes Line Mr. and Mrs. Tony Fromer Fiserv Solutions, Inc. Mr. Alan J. Fumuso Mr. and Mrs. Daniel Fisher u Philip J. Hahn Foundation Mr. and Mrs. Robert L. Fromer l Mr. and Mrs. Robert Fisher Fumuso, Kelly, DeVerna, Snyder, Swart & Farrell, LLP Dr. Nick Fitterman Estate of Agnes Trill Funk u Five Corners Car Wash The G & A Foundation u Flightstar Aircraft Services, LLC Mr. and Mrs. Henry Gabbay u Florence Corporation Mr. and Mrs. Gregory G. Galdi Mr. and Mrs. Thomas J. Flynn u Custom Computer Specialists The Ford Foundation Mr. Stanley C. Gale s The Morris and Natalie Forgash Foundation The Gambino Medical & Science Foundation, Inc. n Mr. Alan Forman Altronix Corporation 40 Friends and Angels: The Tracy Vicere Foundation, Inc. Mr. and Mrs. Thomas Gambino, Sr. Mr. and Mrs. Leif Arntzen Dr. Victor Fornari Mr. and Mrs. Carl Gambino Dr. Jamie A. Fortunoff and Dr. Paul P. Romanello Mr. and Mrs. Thomas Gambino, Jr. Mr. and Mrs. Robert Fortunoff u Mr. and Mrs. Andrew Rotondi Ms. Rene A. Giacalone u Mr. and Mrs. Anthony T. Giaccone u Intermarket Insurance Agency Inc. Mr. and Mrs. Christopher C. Giamo Mr. John V. Gibson u Mr. and Mrs. Alan R. Gilbert Mr. S. Parker Gilbert u Gilead Sciences, Inc. Mr. and Mrs. Edward M. Giles The Clark Gillies Foundation l Aaron & Betty Gilman Family Foundation Mr. Abraham Gindi u Mr. and Mrs. Myron Ginsberg Giorgio Armani Emporio Armani Glen Head Charity Fund, Inc. u Glen Oaks Club, Inc. u Dr. and Mrs. Douglas K. Frank Nathan’s Famous Services, Inc. he Gould-Shenfeld T Family Foundation Mr. Michael A. Gould s The Sarah Grace Foundation for Children with Cancer, Inc. Mr. Martin Granowitz Dr. and Mrs. Jeffrey J. Grant u Mr. and Mrs. Robert Goebert Great South Bay Y.M.C.A. The Arnold P. Gold Foundation Green Art Plumbing Supply Mr. Marc Gold Mr. and Mrs. Martin B. Greenberg s Mr. and Mrs. Alan Goldberg u Mr. and Mrs. Alan I. Greene H The David and Alan Greene Family Foundation, Inc. Garfunkel Wild, P.C. u Mr. Eric Gatoff Mr. and Mrs. Fredric H. Gould s GM Advisory Group Edward & Marjorie Goldberger Foundation Abraham B. & Sarah Frank Fund u Dr. Joanne Gottridge-Patrizi and Mr. Lester Patrizi u Mrs. Pearl Glowatz Mr. and Mrs. Arthur H. Goldberg u Gates Capital Corporation Mr. and Mrs. George E. Gottridge s Granger & Sahasra Endodontic Estate of Robert B. Gardner, Jr. l The Frank Family Foundation Lawrence Scott Events, Ltd. Mr. and Mrs. Ronald A. Gottlieb u Dr. and Mrs. Albert L. Granger The Foundation of the AAGL Frank Crystal & Company Mr. Lawrence Gottesman s Roy Henry Glover Memorial Trust s Garden City Rams - Boys Lacrosse, Inc. George A. Gaston Charitable Trust u Gordon L. Seaman, Inc. u Mr. and Mrs. Ralph Glogower Foundation for Surgical Fellowships u Dr. Kirk N. Garratt Gordon & Silber, P.C. Grandstand Sports & Memorabilia, Inc. The Foundation for READ FragranceNet.com Mr. and Mrs. Donald J. Gordon u Glen Oaks Philanthropic Fund u Howard L. and Judie Ganek Philanthropic Fund Michael J. Fox Foundation for Parkinson’s Research s Goody Two Shoes & The Schnittman Family Mr. and Mrs. Richard Goldberg Mr. Robert M. Goldberg n The Fay J. Lindner Foundation Dr. and Mrs. Bruce Golden Mrs. Mildred Golden u Granite Building 2 LLC Mr. and Mrs. Richard M. Greene u The Niki and Joe Gregory Charitable Foundation l Gristmill Construction Company, LLC Mr. and Mrs. Leonard S. Gruenberg, Jr. Franklin Hospital - Medical Staff Fund s Gavin’s Got Heart Ms. Edna S. Goldman u Mr. Jay Goldman l The Vincent Gruppuso Foundation u Mr. and Mrs. William H. Frazier u Mr. Michael J. Geiger Genentech, Inc. u Mr. and Mrs. Lloyd M. Goldman H Ms. Joanne Grzelak Fresh Meadow Country Club s Mrs. Carolyn W. Fried Dr. Ethan Fried and Mrs. Joan Bester The Fried Foundation, Inc. u Fried, Frank, Harris, Shriver & Jacobson, LLP The Raphael D. and Francine Friedlander Foundation l Friedman Benda, LLC Mr. Clifford H. Friedman u The Gerald J. and Dorothy R. Friedman New York Foundation n Ms. Ruth Friedman 2015 ANNUAL REPORT Mr. and Mrs. Robert Genser T he Joyce and Irving Goldman Family Foundation Ms. Gladys George and Dr. Stuart Orsher s Goldman Sachs & Co. l Mr. and Mrs. Raymond L. George, III Elliot Goldofsky, M.D., P.C. Mr. and Mrs. Gary M. Geresi Mrs. Lola Goldring Myrna and Freddie Gershon Mr. and Mrs. Richard D. Goldstein l The Gershwind Family Foundation l Sarah C. Goldstein Irrevocable Trust u Mr. and Mrs. J. R. Getz Mr. and Mrs. Robert L. Golub Mrs. Ronnie Pashcow Getz Mr. and Mrs. Ernest P. Gonzalez GGG Construction Corporation Goodhart National Gorman Agency, Inc. Dr. and Mrs. Merrill Goodman s Mr. and Mrs. Paul A. Guden Mr. and Mrs. Lee E. Gunderson Mr. Francis C. Gunther Mr. and Mrs. Joseph Gurwin l Dr. Leo Guthart u Patricia and Edward Gutman l The Gynecologic Oncology Group The H Company, Ltd. Dr. Robert D. Haar The Marc Haas Foundation u Mr. and Mrs. Adam Haber Ms. Trudi Haberman H $10,000,000+ Amy Hagedorn n Mr. and Mrs. Peter R. Haje Mr. and Mrs. Stephen L. Hammerman s Hampton Designer Showhouse Foundation, Inc. n $5,000,000 l $1,000,000 s $500,000 Margaret Mellon Hitchcock Foundation u Mr. and Mrs. Francis Ingrassia u Mr. and Mrs. Allen S. Kaplan Dr. and Mrs. Mark S. Hochberg Intelli-Tec Security Services Mr. and Mrs. Ramesh Kapoor u Interboro Management, Inc. The Karches Foundation H International Asbestos Removal Inc. Mr. and Mrs. Brad Karp International Trade Logistics, Inc. Katten Muchin Rosenman Foundation, Inc. Dr. Gary Horbar and Dr. Sharon Hochweiss Dr. Cynthia and Mr. Robert Hoey Sotirios Kassapidis, MD, P.C. Milton and Miriam Handler Foundation s Drs. Ira and Ruth Hoffman u Hanley Funeral Home, Inc. Mr. and Mrs. Steven R. Hoffman Iranian American Jewish Federation of New York u Mr. and Mrs. Alvin Katz Helen Hoffritz Charitable Trust s Dr. Tochi Iroku-Malize Hofstra University ISK Institute for Orthopedics and Sports Medicine Ms. Holly Katz Mr. and Mrs. Bernard Hann l Jeri Finesilver Cancer Foundation Harboglow, Inc. Mr. and Mrs. Robert L. Harding s Harding Educational and Charitable Foundation Harmonic, Inc. Ms. Erica Harold Mrs. Tara Hart and Mr. Edward Tam Mr. and Mrs. Peter J. Hoffman Mr. and Mrs. Ronald P. Hohmann Dr. Peter H. Hollis Islip Breast Cancer Coalition The Honeysuckle Foundation for Children with Cancer u ISS Facility Services, Inc. Mr. Chander S. Iyer u Mr. and Mrs. James B. Hoover u Mr. Anthony T. Izzo u Dr. and Mrs. Alan R. Hartman Mr. and Mrs. Norman H. Harvey u Mr. and Mrs. Richard A. Horowitz u Mr. Walter H. Haydock Mr. and Mrs. Ron J. Horowitz s P & F Industries, Inc. Mr. and Mrs. Ira Hazan l Ms. Catherine Hottendorf Healthcare Association of NYS & Affiliates Mr. and Mrs. Randolph G. Howard, Jr. Healthfirst, Inc. Mr. and Mrs. David J. Hoyt Mr. and Mrs. Michael F. Heaney HRI Health Research Inc. u Friedman, LLP HSBC Philanthropic Programs The William Randolph Hearst Foundations, Inc. l Mr. and Mrs. Charles G. Hughes The Hecht-Levi Foundation H. M. Hughes Co., Inc. Dr. and Mrs. Lawrence P. Hecker Heidelberg Engineering Heidell, Pittoni, Murphy & Bach, LLP Mr. and Mrs. Steven D. Heinemann Benjamin J. Heitner, C.P.A., P.C. Ms. Mary Jane Helenek Mr. and Mrs. Jonathan N. Helfat u Mr. Alexander Hellinger Dr. Jonathan Hemli Mr. Matthew Henebry Henry Schein, Inc. s Elliott and Susan Hershman u Mr. and Mrs. John B. Hess u Marlene Hess and James D. Zirin H Mr. Stephen Hess u Hewlett Associates, LP Hightower Holding, LLC William and Judy Hiltz l Mr. and Mrs. Randall S. Hinden u Island Medical Specialists, PLLC Holten Ave., Inc. Dr. Gary Horbar and Dr. Sharon Hochweiss Mr. and Mrs. Stuart M. Hayim u Investors Bank Foundation C. G. Hughes Company Mr. and Ms. David M. Katz Mr. and Mrs. Michael Katz l Mr. and Mrs. Robert Katz u Mr. and Mrs. Saul B. Katz H Mr. and Mrs. George S. Kaufman Mr. and Mrs. Ivan Kaufman l Mr. and Mrs. Marvin A. Kaufman u Benefits Planning Corporation Mr. Mark Jacobson l Mr. and Mrs. Mitchell Jacobson l MSC Industrial Direct Company, Inc. Mr. and Mrs. Scott Jaffee Dr. and Mrs. Mark P. Jarrett Jaspan Schlesinger, LLP Estate of Elmer L. Jefferson l Estate of Helen T. Jefferson u Mr. and Mrs. James P. Jeffery JemCap LLC Mr. and Mrs. Robert Kaufman n Mr. and Mrs. Steven Kaufman Kaufman, Borgeest & Ryan, LLP Mr. George Kaye The Kazickas Family Foundation, Inc. Kck, Inc. Mr. and Mrs. John C. Kean, III u Kean Development Company W.M. Keck Foundation u The Kelleher Foundation Kellenberg Memorial High School Jet Way Security & Investigations, LLC Kelley Drye & Warren, LLP u Mr. and Mrs. Jack Kelly Hugoton Foundation l Jewish Community Foundation of Greater Hartford, Inc. Hunter Douglas JFK International Air Terminal, LLC Mr. and Mrs. Marc Kemp Hunter Roberts Construction Group The John W. Engeman Theater at Northport Mr. and Mrs. J. Donald Kennedy u Huntington Country Club Jonathan Quattrocchi Sheetrock & Spackling Huntington Hills Center for Health & Rehabilitation Huntington Hospital Medical Staff s Huntington’s Disease Society of America u Mr. Michael Kelly Kenneth J. Delaney Contracting Corp. Dr. James F. Kenny u Mr. and Mrs. Michael D. Jordan u Mr. Paul Kesluk Mr. Arlin Jorge u Kidney & Hypertension Specialists of New York, P.C. Arlindo & Evelyn Jorge Family Trust u Dr. Michael Kim JPMorgan Chase l The David Kimmel Foundation u J.S. Held Incorporated Mr. John J. King u Arnold and Ann Jurdem King Kullen Grocery Co., Inc. u Mr. and Mrs. Jeffrey Jurick s Dr. and Mrs. Alan M. Kisner Mrs. Lyn Jurick l Mr. and Mrs. William Kissam Mr. and Mrs. Harvey B. Kadden Estate of Marion A. Kahn l Kiwanis Club of Huntington Childrens Foundation Inc. Mr. and Mrs. Edward Kalikow Kiwanis, Metropolitan Division Impact Displays Group The Sidney & Pearl Kalikow Foundation Kiwanis Pediatric Trauma Center, NSUH l InfoHedge Technologies Mr. and Mrs. Jeffrey M. Kanter Mr. and Mrs. Laurence S. Hyman Mr. and Mrs. M. Allan Hyman u Ms. Nicole Iacovano I Chera & Sons Foundation, Inc. ICOR Associates, LLC I.J. Peiser’s Sons, Inc. Illumina, Inc. Mr. and Mrs. Richard C. Imbert l u $100,000 THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 41 The Nancy Klauber Forest Foundation u Mr. and Mrs. Sheldon F. Kwiat u Mr. and Mrs. Mark Levitt Mr. and Mrs. William S. Mack Dr. Arthur A. Klein Dr. and Mrs. Sean Lager Estate of Leo J. Levy u The Macula Foundation, Inc. n Lakeville Pace Mechanical, Inc. Mr. and Mrs. Mark D. Levy Maddaloni Jewelers Mr. and Mrs. Frank Lalezarian u Mrs. Valerie Levy u The Joseph Maffeo Foundation u Mr. and Mrs. Kevin Lalezarian u Mr. and Mrs. Victor P. Levy s The MagnaCare Foundation Mr. and Mrs. Brian T. Lally L.I. Automotive Group Mr. and Mrs. Phillip Malakoff LaMay & Sons, Inc. Mr. George J. Liebner Mr. and Mrs. Darryl Mallah l Mr. and Mrs. Ralph E. Lambert u Lifetime Brands, Inc. Mr. Daniel Manalo Dr. Victor R. Klein Dr. Morton Kleiner u Mr. Mark T. Kleinknecht and Ms. Jessica A. Harter-Kleinknecht Mr. and Mrs. Richard P. Kleinknecht u Mr. and Mrs. Martin Lifton l Mr. and Mrs. David Mandelbaum Mrs. Marion Kleinkramer u Landauer, Inc. Lightpath, Inc. KLS Martin, L.P. Mr. and Mrs. Jerry Landsberg u Mr. and Mrs. Mark S. Lilling u Manhasset Women’s Coalition Against Breast Cancer u B & R Knapp Foundation, Inc. u Mr. and Mrs. Clifford P. Lane l Limo Almi Foundation l Ms. Susan Knoepffler Mr. Hank Lane Mr. and Mrs. Peter J. Linchitz Mr. and Mrs. David M. Knott u Mr. and Mrs. Jeffrey B. Lane l Mr. and Mrs. Andrew S. Linder u Kohl’s Cares l Mr. Robert Lane Alfred J. Lippman Foundation Ms. Stephanie Kollar Dr. David Langer Mr. and Mrs. Seth B. Lipsay s Susan G. Komen Greater New York City u Mr. and Mrs. Alexander M. Laughlin u Mr. and Mrs. Leonard Litwin H Mrs. Patricia Marcin Ellen and James S. Marcus l Dr. Arnold Komisar Mr. and Mrs. Curtis N. Launer s Lizardos Engineering Associates, P.C. u Mr. Leigh Marcus Kone, Inc. The Bernard and Muriel Lauren Foundation Ms. Aurora Llanos Mrs. Doris R. Margett Mr. and Mrs. Mark Lauria u Harry J. Lloyd Charitable Trust Mr. and Mrs. Harry F. Mariani l Mr. Carl Lombardi Mr. and Mrs. Morris Mark London Jewelers David J. and Bobbie Marks Family Fund u The Kleinknecht Family Foundation Mr. and Mrs. Peter Kossoy Karen M. Kostroff, MD and Jon R. Cohen, MD u 42 Mr. and Mrs. Jeffrey T. Kovner u The Judith C. White Foundation, Inc. Axis Construction Corporation Mark Lauria Associates, Inc. Mr. and Mrs. Benjamin Lavon The Alice Lawrence Foundation, Inc. The Long Island Association for AIDS Care, Inc. Mr. and Mrs. Peter G. Manian Mr. and Mrs. Alan J. Mann Mr. and Mrs. Robert M. Mann u Mr. and Mrs. David J. Manning Mr. and Mrs. John A. Marciano Mr. and Mrs. George L. Marks u Long Island Charities Foundation Mrs. Nancy A. Marks n Long Island Community Foundation u Dr. and Mrs. Bradley J. Marsh s Dr. and Mrs. David LeDoux Long Island Jewish Medical Center - Administration u Mr. and Mrs. Peter Marsh Mr. and Mrs. Jeffrey A. Kraut Mr. and Mrs. Gerard G. Leeds l Long Island Real Estate Group u Mr. and Mrs. Cary A. Kravet l Mr. and Mrs. Michael S. Leeds l Ms. Arri Lord Mrs. Susan C. Lehrman s L’OREAL USA Mr. and Mrs. Scott Kravet Mrs. Isabel B. Leib Mr. Glenn Lostritto Mr. Stanley Kreitman l Mr. and Mrs. Jonathan W. Leigh l Dr. Yosef P. Krespi Dr. and Mrs. Lyle S. Leipziger u Mr. and Mrs. James J. Loughlin The William Marx Foundation u Estate of Florence B. Kressin l Lenox Hill Hospital OB/ GYN Department Loughlin Management Partners & Company Ms. Jeanne Massimillo Lenox Hill Medical Anesthesiology, PLLC s Ms. Eileen Lovett Mrs. Marjorie A. Matheson u Mr. and Mrs. Leslie A. Lerner Mr. and Mrs. John Lesser Lupus Clinical Trials Consortium, Inc. Mr. and Mrs. Howard M. Lester Lupus Research Institute s The Leukemia & Lymphoma Society, Inc. Mr. Eric Luse Jack & Dorothy Kupferberg Family Foundation Mr. and Mrs. Arthur S. Levine l Ms. Mary Macedonia Dr. Marina S. Kurian Dr. Mitchell E. Levine KPMG, LLP u Dr. and Mrs. Richard S. Lazzaro Mr. and Mrs. Werner H. Kramarsky Sol and Mildred Lederman Supporting Foundation u Kramer Levin Naftalis & Frankel, LLP Kravet, Inc. Ms. Francine Kreuter Mrs. Cathy S. Krieger Mr. Stuart Kronick Mrs. Barbara W. Kummel u The Kupferberg Foundation l Mr. Max Kupferberg l Mr. and Mrs. Seth Kupferberg l Dr. Daniel B. Kuriloff Mr. Laurence A. Levine Dr. Michael Kurzman Mrs. Marjorie Boas Levins and Mr. Jack Levins n The Kurzrok Foundation, Inc. Mrs. Shirley I. Leviton l 2015 ANNUAL REPORT Steel Equities, Inc. Mrs. Eileen Ludwig Greenland n Lymphoma Research Foundation Mrs. Lorraine R. Machiz l Mr. and Mrs. David S. Mack n Earle I. Mack Foundation, Inc. Mr. and Mrs. Fredric H. Mack u Mr. and Mrs. William L. Mack H Mr. and Mrs. Leonard Marsh u Martin Clearwater & Bell, LLP u Gertie F. Marx Private Foundation u The Page & Otto Marx Foundation s The V. & L. Marx Foundation Mr. and Mrs. Thomas P. Mathers Mrs. Helen Matuz Mr. Harold Matzner u Mr. and Mrs. Jeffrey S. Maurer u Maxi Aids, Inc. Estate of Arthur May Mr. and Mrs. Amerigo Mazza Mr. and Mrs. Michael Mazzei u Mr. James McCahill Mr. and Mrs. James McCahill St. James Insurance Group Mr. Anthony D. McCann H $10,000,000+ n $5,000,000 McCarter & English, LLP Millennium Health Foundation Mr. and Mrs. Andrew I. Namm u Mr. and Mrs. F. J. McCarthy u Mrs. Catherine Nelkin Miller Mr. and Mrs. Ralph A. Nappi u Mr. and Mrs. Edward D. Miller l Drs. Tina and Raj K. Narayan Carleigh McCormack Fund l Mr. and Mrs. Kenneth Miller Nash Family Foundation H Ms. Patricia McCrossen Reimerdes and Mr. Rudy Krizan u Mr. and Mrs. Sidney A. Miller u Drs. Beth and Ira Nash Mr. Timothy McDonald Susan E. Miller Mr. and Mrs. Peter G. Nason Estate of Rhoda Miller Goldman Nassau Academy of Family Physicians 341 Commack Road, Inc. The McDowell Foundation MC Electric Mr. Philip L. Milstein l $1,000,000 s $500,000 North Shore Surgical Specialists, MD, P.C. North Shore University Hospital - Administration North Shore University Hospital - Auxiliary n North Shore University Hospital Medical Staff Society Inc. North Shore-LIJ Care Connect Mims Family Painting Corporation Mr. and Mrs. Anthony Nastasi u Dr. Thomas G. McGinn Bushra Mina Pulmonary and Critical Care Physician, P.C. Nate’s Corp. Northfield Bank u Mr. and Mrs. Charles McGuffog The David Minkin Foundation Mr. and Mrs. Raffiq Nathoo Notalvision Inc. Mr. Robert J. McIntyre Mr. and Mrs. Christopher Mitchell National Hockey League Foundation Mr. and Mrs. Edward Novick Dr. Joseph T. McGinn, Jr. u Mr. and Mrs. J. Stewart McLaughlin u Ms. Pamela M. McLaughlin Mr. James McMullen and Dr. Kathryn Crowley u MDeverywhere Mechanical Solutions, Inc. Medtronic, Inc. u Mr. and Mrs. Myles G. Megdal Dr. Ashesh D. Mehta Dr. Rajeev Mehta Mr. and Mrs. Stephen Meister Lewis S. Meltzer, Esq. u The Meltzer Lippe Foundation Marshs of Huntington Mr. and Mrs. Neil Mitchell Dr. Monte Nussbaum Ms. Mindy B. Nelkin Nussbaum Yates Berg Klein & Wolpow, LLP Network For Good NY Auto Giant.com Mr. and Mrs. Richard E. Montag Neuberger Berman, LLC NYBKW Charitable Foundation u The Don Monti Memorial Research Foundation, Inc. H Neurological Surgery, P.C. N.Y. Epilepsy & Neurology, PLLC New York Blood Center, Inc. Richard B. Nye and Francesca Stanfill Nye l The Ambrose Monell Foundation l Monster’s Kids u Erin and Richard D. Monti Caroline and Arthur Saladino The James D. & Kay Y. Moran Foundation Morgan Stanley u Ms. Linda Merinoff u Mrs. Susan L. Merinoff H Merit Service Solutions, LLC Ms. Christina Merrill Merrill Lynch, Pierce, Fenner & Smith Inc. u Estate of Harold W. Metal u Metropolitan Commercial Bank Metropolitan Property Services Mr. and Mrs. Lee Metzendorf u Estate of Joseph and Rosalie Meyer l Mr. and Mrs. Martin Meyers Mr. and Mrs. Michael Meyers The Lee Michaels Group, LLC Ms. Penny Novick u Mr. and Mrs. Harold Nelkin n Mr. and Mrs. Joseph Moinian The H&S Menowitz Foundation u Mr. and Mrs. Charles Merinoff l The Northern Trust Company Mr. and Mrs. James L. Neisloss s Sylvia Modeste, R.N. Mr. and Mrs. Patrick Moravick Ms. Rita Mercieca National Philanthropic Trust DAF s Northeastern Aviation Corporation Nueva Generacion Manufacturas S.A. De C.V. Memorial Sloan Kettering Cancer Center Robert and Joyce Menschel Family Foundation Nastasi & Associates, Inc. Craig H. Neilsen Foundation u Dr. and Mrs. Mark A. Mittler Mr. and Mrs. Gerald Mordfin Moritt Hock & Hamroff, LLP Mr. and Mrs. Gary E. Morris New York Community Bank Foundation s NYS Troopers PBA Signal 30 Fund, Inc. New York Container Terminal, Inc. u OB-GYN Services, P.C. New York Crohn’s Foundation l Estate of Bella Oberman New York Fire Alarm Association Inc. Mr. and Mrs. Denis O’Brien Dr. and Mrs. Stephen A. Obstbaum u The New York Mets Foundation, Inc. l Oceanic Heritage Foundation u Mrs. Melanie Morris New York State Council on Leadership and Student Activities Mr. Robert Morris New York State Health Foundation Mr. and Mrs. Sanford Morris Newport Private Group Mr. and Mrs. Stanley J. Morris u Dr. Stephen J. Nicholas u The Rampart Group Mr. and Mrs. Kyle R. Mostransky Jamie Nicholls & Fran Biondi Charitable Trust Mr. and Mrs. Morris W. Offit The Olin Family Foundation Inc. u Mr. Daniel Olsen Mr. and Mrs. Stuart P. Olsten l Olympus America Corporation Sandler O’Neill and Partners, LP Mr. Richard Nichols Ophthotech Corporation Ethel & Alexander Nichoson Foundation Optos, Inc. Optovue, Inc. Mr. and Mrs. Richard Nicotra Original Energy Nidek Incorporated Ms. Nataliya Orlovskaya Niki Charitable Art Foundation s Mr. and Mrs. Justin Ort Mr. and Mrs. Richard H. Murcott u Carole and Dr. Michael Nimaroff Dr. Rafael Ortiz Mr. and Mrs. Thomas P. Murphy NLD for Pediatrics n Dr. Viola Ortiz Mr. and Mrs. Stanley Muss u Dr. and Mrs. Marc A. Nolan Dr. and Mrs. Michael Ostad North American Data Forms Inc. OTG Management, LLC North American Partners in Anesthesia, LLP n Mr. and Mrs. Jonathan Otto North Shore Implant & Oral Surgery Associates Pacira Pharmaceuticals, Inc. u The Mount Sinai School of Medicine u MSG Holdings, L.P. Mr. and Mrs. Paul Mullins u Mullooly, Jeffrey, Rooney & Flynn, LLP yman and Ruth Muss H Foundation, Inc. Michaels Philanthropic Foundation s Mr. and Mrs. Robert J. Myers u Drs. Michael F. and Mary Ann Michelis u Dr. and Mrs. Souhel Najjar Dr. and Mrs. Jason J. Naidich u $100,000 Oxford Airport Technical Services Mr. Anthony Paduano THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 43 Palm Bay International, Inc. Priority One Ambulance Dr. and Mrs. Harold L. Rekate Mr. and Mrs. Peter W. Rosenthal Pam’s Pals Inc. Professional Physical Therapy Drs. Maria and Angelo Reppucci Mr. and Mrs. Robert D. Rosenthal l PAN Long Island Challenge Inc. Project to Cure l Restaurant Management Inc. Mr. and Mrs. Edward Pantzer PS Marcato Elevator Co., Inc. Retina Specialist, P.C. Dr. Mitchell S. Roslin Mr. and Mrs. James A. Pappas PTW, Inc. Mr. David Rewers Dr. and Mrs. Bernard M. Rosof u Public Administrator of Kings County Rheumatology Research Foundation u Mr. and Mrs. George H. 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