Wearable textile-based phototherapy systems

Wearable textile-based phototherapy
systems
Ir. Koen van Os
Intelligent textiles, Philips Research, Eindhoven, The Netherlands
pHealth, June 28th, Tallinn Estland
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Introduction
•  Imagine a world in which electronics are free from their rigid, confining
encapsulation, are intimately integrated into the fiber of our daily lives
and distributed throughout our ambient environment.
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Koen van Os, pHealth2013
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Content
•  Philips
•  Philips and e-textiles
•  Place-it project
–  Industrialization
–  End-user approach
–  Clinical study
•  Next steps in PLACE-it
•  Conclusions
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Koen van Os, pHealth2013
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Philips
Improving people’s lives through meaningful
innovation.
Healthcare
Consumer Lifestyle
Lighting
Comfortable, wearable, light emitting devices can be envisioned in all three parts
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Koen van Os, pHealth2013
Philips Research
Facts & Figures
“meaningful innovations that improve
people’s health and well-being”
•  One of the world’s largest private research
institutions
•  Founded in 1914
•  Research budget ~1% of Philips turnover
•  650 scientific publications every year
•  >20 part-time professors
•  Laboratories in the Netherlands, Germany, the
United Kingdom, France, India, USA, and China
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Koen van Os, pHealth2013
Why smart textiles
How many materials
……... like textiles?
are familiar to and trusted
by users
can be stretched, folded and
reshaped again and again
can be produced in high volumes
for low costs (roll to roll)
can be breathable and lightweight
can be combined with others by:
- stitching and sewing
- good adhesion by glues
fit perfectly around moving bodies
are robust enough to withstand the torture in washing machines
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Making use of smart textiles properties
Textile properties
Comfortable wearable electronics
•  conformable
•  efficient sensors (body parameters) and
actuators (interaction) on the body
•  breathable
•  lightweight
•  robust
•  high production
speed
•  sensors and actuators are easily placed in the
correct position
•  continuous monitoring
•  therapy while going about your business
•  sustainable
Large-area electronics
•  sensor systems for “ambient intelligence”
•  lighting
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Categories
First
Second
Third
Georgia Tech
Wearable Motherboard
Weaving data lines
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Weaving / embroidery
Remove before wash
Hybrid technologies
Traditional
electronics
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Functional fibers
Solar / LED / OLED
Functional fabrics
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•  Circuits need to be
extremely rugged exposed to
mechanically demands
(Fabrication / Use)
•  The comfort and washability
of the smart textile should
not be affected by the
presence of the circuits.
•  Circuits require power
supplies that are light-weight
and have a high capacity
•  Commercial smart textiles
need to comply both the
textile and electronics field.
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Some requirements
What we expect from flexible display
What we expect from e-textile
R = 50 mm minimum
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R = 0.5 mm minimum
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First Philips e-textile application: Lumalive concept
Seamless integration of LED
technology in clothing
Real eye-catcher at events
Dynamic content can be customized
for every customer
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LED -OLED Light and wearables
1
Black Eyed Peas project (2011)
Roger van der Heide, Philips Design
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Michal Jackson project (2009)
Philips Lumalive
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Luminous Textiles
Philips + Kvadrat textiles
1
2
Soft light
Soft touch
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Soft sound
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PLACE-it project
•  Platform for Large Area Conformable Electronics by InTegration:
•  Technology platform for thin, lightweight and free-form optoelectronic systems
–  On-body health and wellness applications
–  New dimensions in product design
•  Aim:
–  integration platform of different flexible optoelectronic technologies.
–  Create conformable devices
–  Formulate industry design rules.
–  Build demonstrators
•  Feb 2010 – Nov 2013
• PLACE-it consortium
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Consortium
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PLACE-it Integration of technologies
Co-development of 3 technologies with the goal of
heterogeneous integration
imec
TNO/Holst
Foil
Philips Research
TU Berlin
Elastic
(Silicone, PU)
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Textile
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Based on PLACE-it technology:
Light therapy for pain relief
Philips BlueTouch …
www.blueledtherapy.com
www.led-schmerztherapie.de
… for treatment of back pain
A unique platform for effective light-based therapies
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pHealth2013
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Clinical background: muscular and joint pains
•  About 37% of the global population experience
muscular or joint pain which ranges from tolerable to
intolerable.
•  19% of adult Europeans suffer from chronic muscle
pain which affects quality of their lives
www.bentolson.co.uk/images/photos/back%20pain%20large.jpg
•  About 40% of pain sufferers view their pain
management solutions as inadequate
•  Most muscle pain occurs in the neck, shoulder and
back region.
houndsgood.com/wp-content/uploads/2009/07/backpain.jpg
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Blue light
Use LED property: narrow emission spectrum
– apply optimal wavelength, exclude toxic wavelengths
Advantages blue light
- Stimulates body’s own processes
- No drug related side effects
- Still effective after treatment
NO effects
Direct heat sensation
Nitric Oxide (NO⋅)
release
stimulates blood flow,
oxygenation and nutrition supply
can protect cells against oxygen
shortage and
decreases inflammation
improves cell functioning and can
prevent muscle damage
Deep heat penetration
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Wearable light therapy
Combine small LED dimensions and electronic textile
Body fit by stretchable strap
- Comfort
- Combine with other activities
- Unobtrusive
Flexible device
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BLUE TOUCH DESIGN
•  END USER DRIVEN
•  CLINICAL STUDY
•  INDUSTRIALIZATION
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END-user design driven
COMFORT
Design with textile qualities
Comfort experienced
End-user questionnaires
DISCOMFORT
Discomfort measured
Heat on skin by phototherapy
Thermal behavior of textile construction
Biocompatibility of materials (skin touching)
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Textile qualities
Edge finish
- Very reliable assembly
Soft
Light weight
Surface finish
-  Aesthetics
-  Touch
-  Hygienic + cleanable
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BlueTouch Comfort features
2 Body locations
Sensor
-  Overheating protection
-  Energy saving
-  Eye safety
3 Intensity levels
Low
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Medium
High
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BLUE TOUCH DESIGN
•  END USER DRIVEN
•  CLINICAL STUDY
•  INDUSTRIALIZATION
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Clinical study
Improve understanding of the physiological
effects of LED irradiation of the skin
Primary objectives for PLACE-it demonstrator:
–  Establish further evidence for the mechanism of NO generation in vivo
–  Demonstrate increased blood flow
–  Asses comfort and side effects of irradiation
Bioresponses measured include:
- Nitric oxide (NO) release
O2C: - blood flow
- blood flow velocity
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- oxygen saturation
- skin temperature
- fraction of hemoglobin
-  subjective heat sensation
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NO measurement set-up
He
flow controller
collection chamber
lamp unit
58/100 mW/cm2
55 mm
valve 1
cushion
lab jack
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collection chamber
valve 2
ECO physics NO detector
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12)
NO release
Blue (453 nm)
Green (524 nm)
1000
1000
900
Control (min)
Control
1000
900
Control (max)
800
900
Control (min)
Control (max)
800
Irradiated (min)
Irradiated
700
Irradiated (max)
Control (max)
800
Irradiated (min)
Irradiated
600
500
400
500
400
300
100
200
100
0
100
0
-­‐100
6 (5⅓)
1 (2)
2 (5⅓)
3 (8⅔)
Irradiated (m
300
0
5 (2)
6 (5⅓)
-­‐100
Cycle (Minutes after lamp on/off)
4 (12)
5 (2)
6 (5⅓)
1 (2)
3 (8⅔)
Irradiated (m
400
200
2 (5⅓)
Control (ma
Irradiated (max)
500
200
1 (2)
Control (min
600
300
5 (2)
-­‐100
lamp on/off)
Irradiated (min)
700
Irradiated (max)
600
NO release (a.u.)
NO release (a.u.)
NO release (a.u.)
700
Control (min)
Control
4 (12)
Cycle (Minutes after lamp on/off)
2 (5⅓)
3 (8⅔)
4 (12)
5 (2)
6 (5⅓)
Cycle (Minutes after lamp on/off)
similar skin temperatures reached for blue and green irradiation
www.place-it-project.eu : NEWSLETTERS
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p = 0.0014
p = 0.006
p = 0.47
p = 0.21
p = 0.0003
p = 0.005
p = 0.03
Back: blue (453 nm), 58 mW/cm2
7
1 mm
7.0
6 mm
6.0
∆T
6
5
5.0
4
4.0
3
3.0
2
2.0
1
1.0
0
0.0
-­‐1
-­‐1.0
-­‐2
abdomen
back
adomen
15 min
Average temperature difference
Relative difference in average blood flow
8.0
p = 0.36
Blood flow
back
15 + 5 min
•  Not too hot; generally comfortable warmth
•  No skin discolouration other than transient erythema
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BLUE TOUCH DESIGN
•  END USER DRIVEN
•  CLINICAL STUDY
•  INDUSTRIALIZATION
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Industrialization
Conductive wire based fabrics inside
Industrialization achievements:
•  Weaving
•  Conductive wires
•  Gluing interconnects with LEDs
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Industrial feasible
High performing
Full automatic
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E Textiles Learnings @ Philips
-  Design for comfort
- End-user approach
- Make use of intrinsic textile qualities
-  Clinical evidence
- Medical certification
- Endorsement
-  Industrialization
- Differences in industries
- Where to enter the supply chain
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PLACE-it application
Phototherapy for Jaundice
Neonatal jaundice
- Increased level of Bilirubin in the blood
- Can cause brain damage
Common treatment is phototherapy
Electronic textiles
can bring improvement
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Clinical background: neonatal jaundice
•  Treatment is required for 80% pre-term babies
•  Treatment is required for 10 – 30% term babies
•  Length and intensity of treatment differ per baby
and can be days
•  The most successful treatment is blue light
(1 – 5 mW/cm2)
http://www.doctorshangout.com/profiles/blogs/life-smile
•  US market supplies home care solutions,
in Europe this is hospital care.
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Bilirubin ‘Blanket’
-  High efficacy
-  Kangaroo care and feeding (important for bonding)
possible during treatment
-  Pleasant for baby, nurses and parents
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Conclusions
•  Challenges for successful electronic textile products include designing
meaningful products which capture textile qualities and minimize the
ecological impact.
•  Smart textiles play an important and crucial role in large area lighting
and flexible light for health and well-being.
•  A close cooperation of experts and clinical testing is a prerequisite to
gain acceptance and endorsement by medical stakeholders.
•  Philips has already electronic textile products successfully
industrialized: many lessons learned
•  PLACE-it and is for us a perfect project to develop application and
industrialization knowledge.
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Acknowledgements:
PLACE-it Project –members
Philips Light & Health Venture
Intelligent Textiles team Philips Research / Philips Innovation Services
By-Wire.net, Marina Toeters
Thank you very much for your attention!
Contact information: Koen.van.Os@Philips.com
Philips Research