Systemic lupus erythematosus and chronic myeloid leukemia: mere

Journal of Applied Pharmaceutical Science Vol. 4 (11), pp. 098-100, November, 2014
Available online at http://www.japsonline.com
DOI: 10.7324/JAPS.2014.41117
ISSN 2231-3354
Systemic lupus erythematosus and chronic myeloid leukemia: mere
coexistence or association?
Rudrajit Paul, Jayanti Ray, Babulal Daulagajao, Rojina Choudhury, Sanjoy Bhattacharya
Department of Medicine, Medical College Kolkata, 88, College Street, Kolkata- 7000 73, India.
ARTICLE INFO
ABSTRACT
Article history:
Received on: 24/06/2014
Revised on: 11/08/2014
Accepted on: 09/10/2014
Available online: 27/11/2014
Systemic Lupus Erythematosus (SLE) is a multisystem connective tissue disorder associated with increased
predisposition to haematological malignancies. Myeloid series malignancies are rarely associated with SLE. We
here report a case of Philadelphia chromosome positive chronic myeloid leukemia (CML) associated with SLE in
a 36 year old Indian housewife. This is probably the first such case to be reported from India and only a handful
of such cases have been reported in World literature till now. The patient presented initially with leukopenia. She
was treated with imatinib with good results.
Key words:
SLE, CML, imatinib,
eosinophilia, myeloid
malignancy.
INTRODUCTION
Systemic Lupus erythematosus (SLE) is a multi-system
disease associated with a variety of clinical manifestations.
Haematological manifestations are quite common in SLE and
include anemia, leukopenia, thrombocytopenia or clotting
disorders (Sasidharan et al., 2012). In fact, in some studies,
haematological manifestations have been found to be the
commonest presenting symptom of SLE (Sasidharan et al.,
2012). Haematological malignancies are sometimes associated
with SLE and malignancies of both myeloid and lymphoid
lineage have been reported (Lu et al., 2013). Among these,
Chronic myeloid leukemia (CML) is very rarely associated with
SLE. We here report a case of CML associated with SLE. As far
as we searched, this is probably the first such case to be reported
from India.
The case report
A 36 years old female housewife presented to the
emergency with shortness of breath and pain in left upper
abdomen for two weeks. Both the symptoms were gradually
.
.
* Corresponding Author
Rudrajit Paul, Medical College Kolkata, Kolkata, India.
Email: docr89@Gmail.Com
progressive and at the time of presentation, she was severely
dyspnic with inability to complete sentences. There was associated
orthopnoea, but fever or chest pain was absent. Bipedal edema and
pallor was also present. Abdominal examination revealed mild
splenomegaly. After admission, analysis of past documents
revealed that she was a diagnosed case of SLE for last two
years.She had fulfilled six criteria of ACR guidelines. Renal biopsy
done at that time had revealed stage IV SLE nephritis. However,
after few months of treatment including two pulses of
cyclophosphamide, she had stopped visiting the hospital and was
not taking any treatment. Past blood records showed (figure 1)
hemoglobin of 6.4 gm/dl with total leukocyte count of 1390/cmm
(N60L36E2) and platelet count of 100 000/cmm. Urinary protein
two years ago was 3.1 gm/24 hours. At present admission, blood
reports revealed hemoglobin of 6.5 gm/dl with total leukocyte count
(TLC)of 20 000/cmm (N76L12E12) and ESR of 71 mm in 1st hour.
Platelet count was 190 000/cmm. She was presumed to have
systemic infection and started on I.v. antibiotics. Other tests
revealed serum LDH of 2229 IU/L and urea/creatinine of 51/1.7
mg/dl respectively. Chest X ray showed right sided pneumonitis
and mild cardiomegaly. Ultrasonography of abdomen revealed
splenomegaly (15.5 cm) with no other pathology. Serum
C3 level was 101 ng/dl and anti dsDNA was positive at
1:40 titre (Cliff method). She was also started on i.v. torsemide.
© 2014 Rudrajit Paul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License -NonCommercial-ShareAlike
Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/).
Paul et al. / Journal of Applied Pharmaceutical Science 4 (11); 2014: 098-100
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With use of these drugs, her dyspnea was abated and she
discharged herself against medical advice after three days. One
month later, the patient was again admitted with left sided
abdominal pain.
hydration. Slowly, her TLC came down to 21000/cmm and
hemoglobin also improved to 8.1 gm/dl. The patient is now under
follow up. She has not shown any new manifestations of SLE.
Fig. 1: Line graph showing the sequential blood reports of the patient.
Fig. 3: Karyotype study showing Ph chromosome.
Examination revealed a firm slightly tender splenomegaly. She
was pale and there was mild fever. Blood tests revealed
hemoglobin of 6.9 gm/dl with TLC of 31130/cmm. Differential
count revealed Neutrophil 66%, myelocyte 10%, metamyelocyte
11% and eosinophil of 5%. Platelet count was 120000/cmm.
Reticulocyte count was 3.6% and direct Coomb’s test was
negative. Liver function test was normal. Bone marrow
examination revealed (figure 2) features of myeloproliferation
with occasional foci of fibrosis.
Fig. 2: microscopic picture of bone marrow aspiration study of the patient.
Chromosomal analysis of cells from bone marrow
aspirate showed presence of Philadelphia chromosome (figure 3)
in 69% of the cells. This was thus diagnosed as a case of chronic
myeloid leukemia (CML). Meanwhile, the patient started to
develop hyperviscosity symptoms like headache and visual
dimness. Retinoscopy showed engorgement of retinal veins. She
was started on oral imatinib and hydroxyurea along with
DISCUSSION
SLE is associated with increased risk of some
malignancies. Rarer cancers like those of female genital tract and
hepatobiliary cancers are increased in SLE patients compared to
the general population (Bernatsky et al., 2009). However, the main
increased risk is in haematological malignancies, especially nonHodgkin’s lymphoma (NHL) (Bernatsky et al., 2009). The exact
link between SLE and cancers is unknown; besides the disease
process itself, use of drugs like cyclophosphamide is also said to
be responsible for the development of malignancies (Bernatsky et
al., 2009).
Myeloid malignancies have been reported in SLE
patients (Löfström et al., 2009). In a recent study, eight cases of
SLE with myeloid leukemia were reported(Löfström et al., 2009).
Similar other cases have been rarely reported from elsewhere.
Leukopenia in SLE was found to be a risk factor for later
development of myeloid leukemia (Löfström et al., 2009). In our
case too, the initial TLC was 1390/cmm. Thus, sudden
normalisation of erstwhile low TLC in SLE may be an indication
of incipient leukemia in these patients. In addition, like in our case,
some patients may show unusual haematological features like
eosinophilia. Sometimes, these patients are initially diagnosed as
myelodysplasia (MDS) and only subsequent follow up can
diagnose the leukemic transformation. The use of cytotoxic drugs
like cyclophosphamide or azathioprine is not consistently
associated with development of leukemia.In the aforementioned
case series, out of the eight myeloid leukemia cases, only two were
CML (Löfström et al., 2009). Both the patients were aged 60 and
above and survival after diagnosis of CML was 6—9 months. In
contrast, our patient was diagnosed at 36 years of age and she has
lived for ten months after the diagnosis of CML till now.
Some studies have found that myeloid malignancies are
increased in patients with autoimmune conditions (Andersonet al.,
2009). Specifically, they found acute myeloid leukemia and MDS
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Paul et al. / Journal of Applied Pharmaceutical Science 4 (11); 2014: 098-100
to be associated with autoimmune conditions like rheumatoid
arthritis and SLE (Anderson et al., 2009). The exact cause of this
association is unknown but it is postulated to be due to common
genetic predispositions. Also, it is said that direct damage to the
myeloid precursors by the underlying disease may be responsible
for the malignant transformation(Andersonet al., 2009). A case of
CML in rheumatoid arthritis was reported from Morocco in 2012
(Mansouri et al., 2013). However, that case presented with blast
crisis and was Philadelphia chromosome (PH) negative. By
contrast, our patient was PH positive and is still in stable phase.
CML has only rarely been reported in SLE. No such case
has been reported from India till now. A report from Delhi
described a case where interferon treatment for CML led to the
development of SLE nephritis (Goyal et al., 2005). But in our
case, the SLE developed earlier. In another case report from Italy,
bone marrow transplant for CML in blast crisis led to cure of the
SLE too (Meloni et al., 1997). However, there is no guideline on
proper management of SLE with CML. Since our patient was PH
positive, she was given imatinib with good results. Interferon
should probably be avoided in these cases.
CONCLUSION
Autoimmune diseases like SLE are sometimes
associated with haematological malignancies. Regular follow up is
needed to diagnose the disease at an early stage. Treatment needs
to be individualized and multidisciplinary approach is needed for
proper management.
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How to cite this article:
Rudrajit Paul, Jayanti Ray, Babulal Daulagajao, Rojina Choudhury,
Sanjoy Bhattacharya. Systemic lupus erythematosus and chronic
myeloid leukemia: mere coexistence or association? J App Pharm
Sci, 2014; 4 (11): 098-100.