2008 - 2009

Transcription

2008 - 2009

HEART AND STROKE FOUNDATION
RESEARCH REPORT
2008-2009
www.hsf.ca/research
Heart and Stroke Foundation | Research Report 2008-2009
MISSION
The Heart and Stroke Foundation, a
volunteer-based health charity, leads
in eliminating heart disease and stroke
and reducing their impact through
the advancement of research and its
application, the promotion of healthy
living, and advocacy.
Every seven minutes in Canada,
someone dies from heart disease
or stroke.
Heart disease and stroke are
two of the three leading causes
of death in Canada; more than
50,000 strokes, an estimated
75,000 heart attacks, and up to
45,000 cardiac arrests occur
every year.
The Heart and Stroke Foundation
has invested more than $1.2 billion
in leading-edge heart and stroke
research in the last 54 years.
The mortality rate from heart
disease and stroke has decreased
by 70% since 1952, thanks in large
part to our research.
Cover Photo: Dr. Robert A. Hegele (Robarts Research Institute) was the recipient in 2008-2009 of two Grants-in-Aid from the Heart and Stroke Foundation
of Ontario, titled “Genomics of hypertriglyceridemia” and “Phenomics and genomics of atherosclerosis in monogenic metabolic syndrome”.
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TABLE OF CONTENTS
MESSAGE FROM THE CHAIR, RESEARCH POLICY AND
FIGURES
PLANNING ADVISORY COMMITTEE........................................ 1
Figure 1. HSF Research Funding by Program (2008-2009)..... 6
ACKNOWLEDGEMENTS............................................................. 3
Figure 2. HSF Research Funding Trends by Program
1
PURPOSE AND SCOPE....................................................... 3
2
SUMMARY TABLES.............................................................. 4
3
RESEARCH FUNDING OVERVIEW.................................... 6
3.1
Research Roles.......................................................... 6
3.2
Scientific Review Process......................................... 6
3.3
Research Enterprise Components.......................... 6
3.4
Investments across Health Research Themes....... 7
4
2008-2009 RESEARCH FUNDING BY PROGRAM............ 8
4.1
Federation Research Fund....................................... 8
4.2
National Personnel Awards..................................... 9
4.2.1Heart and Stroke Foundation
Prestigious Awards...................................... 12
4.3
Grant-in-Aid............................................................. 12
4.4
Province-specific Research Initiatives................... 15
4.4.1Research Chairs, Professorships, and
Investigatorships.......................................... 15
(2004-2009)................................................................... 7
Figure 3. HSF Research Funding by Health Research
Theme (2008-2009)...................................................... 7
Figure 4. H
SF Research Funding Trends by Health
Research Theme (2005-2009)..................................... 7
Figure 5. Federation Research Fund Leveraged Funding
(2004-2009)................................................................... 9
Figure 6. Federation Research Fund Funding by Health
Research Theme (2008-2009)..................................... 9
Figure 7. Federation Research Fund Funding Trends by
Health Research Theme (2005-2009)......................... 9
Figure 8. National Personnel Awards Funding by Health
Research Theme (2008-2009)................................... 11
Figure 9. National Personnel Awards Funding Trends by
Health Research Theme (2004-2009)....................... 11
Figure 10. Number of National Personnel Award
4.4.2 Provincial Personnel Awards...................... 16
Applications Submitted and Funded by
4.4.3 Other Provincial Initiatives.......................... 18
Province/Territory (2008-2009).................................. 11
Figure 11. Grant-in-Aid Funding by Health Research
Theme (2008-2009).................................................... 13
TABLES
Table 1. Summary Federation-wide and Province-specific
Research Funding (2008-2009)....................................... 4
Table 2. Detailed Federation-wide and Province-specific
Research Funding (2008-2009)....................................... 4
Table 3. Number of National Personnel Awards and
Investment of Funds (2008-2009)................................. 10
Table 4. HSF National Personnel Awards by Health
Research Theme (2008-2009)....................................... 10
Table 5. Number of Grants-in-Aid and Investment of
Funds (2008-2009)......................................................... 12
Table 6. Research Chairs, Professorships, and
Investigatorships (2008-2009)....................................... 15
Table 7. HSF Provincial Personnel Awards Funded
(2008-2009)..................................................................... 16
Table 8. Other Provincial Research Initiatives (2008-2009)...... 18
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Figure 12. Grant-in-Aid Funding Trends by Health
Research Theme (2004-2009)................................... 13
Figure 13. N
umber of Grant-in-Aid Applications
Submitted by Province/Territory (2004-2009)......... 14
Figure 14. Number of Grant-in-Aid Applications Funded
by Province/Territory (2004-2009)............................ 14
APPENDIX A: FEDERATION RESEARCH FUND..................... 21
NEW INITIATIVES....................................................................... 24
Secondary Stroke Prevention Health Services and Care
Team Grants 2009............................................................. 24
Novel and Exploratory Research Fund 2009................... 25
Vascular Cognitive Impairment 2009................................ 25
Applied Public Health Chair 2008..................................... 26
Childhood Obesity Prevention and Treatment
Operating Grants 2008.................................................... 26
Intervention Research (Healthy Living and Chronic
Disease Prevention) 2008................................................. 27
Focus on Stroke 7 2008...................................................... 27
DEVELOPMENTAL INITIATIVE.................................................. 29
Secondary Stroke Prevention Health Services and
Care Development Grants 2008..................................... 29
CONTINUING INITIATIVES........................................................ 30
Research Programs...................................................................... 30
Novel and Exploratory Research Fund 2008................... 30
Built Environment, Obesity and Health 2007.................. 31
Monitoring and Optimizing CPR 2007............................. 33
Resuscitation and Knowledge Transfer 2007................... 33
Cardiovascular Complications of Diabetes 2007............ 34
Reducing Health Disparities and Promoting Equity
for Vulnerable Populations - Interdisciplinary Capacity
Enhancement (ICE) Team Grants 2006........................... 35
Genomic Medicine and Human Development 2005..... 35
Canadian Tobacco Control Research Initiative 2004...... 36
Inflammation and Thrombosis 2004................................. 36
Molecular and Cellular Imaging 2004.............................. 37
Obesity New Emerging Teams (NETs) 2004.................... 37
Palliative / End of Life Care 2004...................................... 38
Regenerative Medicine 2004............................................. 38
Resuscitation Outcomes Consortium (ROC) 2004.......... 39
Gender and Sex Determinants of Circulatory and
Respiratory Health - Interdisciplinary Capacity
Enhancement (ICE) Team Grants 2004........................... 39
Training Programs....................................................................... 40
Focus on Stroke 6 2007...................................................... 40
Focus on Stroke 5 2006...................................................... 42
Focus on Stroke 4 2005...................................................... 43
Focus on Stroke 3 2004...................................................... 43
Target Obesity Personnel Awards 2004........................... 43
Strategic Training Initiative in Health
Research (STIHR) 2003...................................................... 44
APPENDIX B: NATIONAL PERSONNEL AWARDS................. 47
Doctoral Research Awards................................................. 48
Research Fellowships......................................................... 53
New Investigators............................................................... 57
Nursing Research Fellowships.......................................... 60
Visiting Scientist.................................................................. 60
Industry-Supported Research Fellowship Awards.......... 61
APPENDIX C: GRANTS-IN-AID................................................. 63
British Columbia/Yukon..................................................... 64
Alberta/Northwest Territories/Nunavut........................... 68
Saskatchewan . ................................................................... 74
Manitoba ............................................................................ 75
Ontario ................................................................................ 76
Quebec ............................................................................. 102
New Brunswick . ............................................................... 111
Nova Scotia ...................................................................... 112
Newfoundland and Labrador . ....................................... 113
APPENDIX D: RESEARCH CHAIRS, PROFESSORSHIPS,
AND INVESTIGATORSHIPS............................ 115
APPENDIX E: PROVINCIAL PERSONNEL AWARDS............ 117
Saskatchewan.................................................................... 118
Manitoba .......................................................................... 118
Ontario............................................................................... 118
APPENDIX F: OTHER PROVINCIAL INITIATIVES.................. 127
British Columbia/Yukon................................................... 128
Alberta/Northwest Territories/Nunavut......................... 128
Saskatchewan.................................................................... 128
Ontario............................................................................... 128
Quebec.............................................................................. 132
New Brunswick.................................................................. 134
Nova Scotia....................................................................... 134
APPENDIX G: RESEARCH COMMITTEE MEMBERS .......... 135
APPENDIX H: DEFINITION OF HEALTH RESEARCH
THEMES . .......................................................... 139
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MESSAGE FROM THE CHAIR, Research Policy and
Planning Advisory Committee
Canada is seeing a dramatic increase in
physical inactivity, obesity, diabetes and
hypertension – conditions that lead to heart
disease and stroke. Investing in world-class
cardiovascular and cerebrovascular research
has never been so important.
We imagine better lives, made possible by research.
We envision a healthier future enabled by life-saving research.
Through leading-edge genetic science, our researchers are
identifying new risk factors that lead to heart disease and stroke.
As a result, we believe that within five to ten years we could have
new preventive therapies for those at risk. We are also helping to
improve existing treatments and create new ones that will help
to ensure that people living with the effects of heart disease and
stroke can thrive.
This report reflects our federation-wide research investments
and the significant contributions of diverse organizations who
have partnered in HSF initiatives across the research spectrum.
In the following pages, we’ve provided details of the projects we
fund for over 900 researchers and teams across Canada. Here are
a few that caught my attention this year:
• Connecting the dots. What’s the best way to move research
into action? We believe it’s by bringing together the people
who are creating the knowledge with the people who’ll be
using the knowledge. The result – a series of Heart and Stroke
Foundation researcher interaction workshops in areas such
as resuscitation, and the built environment. The gatherings
give HSF researchers working in a similar area the chance to
meet with a group of key influencers – such as health care
policy makers, practitioners, and planners – and present
their knowledge transfer and exchange plans. Researcher
interaction workshops are an integral part of HSF’s Managed
Research Cycle, which aims to accelerate the translation of
research results into policy and practice.
• Preventing secondary stroke. To further advance the goals
of the Canadian Stroke Strategy, we’ve partnered with the
CIHR Institute of Circulatory and Respiratory Health and the
Canadian Stroke Network in the Secondary Stroke Prevention
Health Services and Care research initiative. Three major
studies from across the country will examine the management
and care of people who have had a TIA or stroke to prevent
stroke recurrence – ensuring optimal outcomes for stroke
patients (see page 24).
• Reversing Canada’s obesity trend. Inactivity and overeating
crept into our culture to create an obesity epidemic – but our
first Federation-wide Research Chair is confident Canadians
can change. Dr. Kim Raine’s appointment as Applied Public
Health Chair marks an important step in the battle against
obesity. She’s focused on understanding and countering the
changes in our society that have contributed to creating a
culture of inactivity and over-eating. She’ll tackle the issue
head-on by conducting high-quality intervention research
with the aim to integrate the findings into communities and
Canadian society. The doctor lives what she preaches: she
has completed more marathons than she has fingers (see
page 26).
• Bringing research findings home. While generating new
knowledge emphasizing the interaction between genes
and environment, Dr. Sonia Anand, our first Research Chair
in Population Health Research, is focused on making sure
research findings reach groups at special risk of heart disease
and stroke – ethnic groups, women, and people at a low socioeconomic status. Using novel tools such as text messages
and e-mails targeting the groups’ specific risks, her team
is assessing which knowledge transfer and exchange tools
work best. The group is also sharing knowledge with other
population health researchers by developing a website where
researchers can share information and tools (see page 116).
• Life-saving research. This year the Foundation committed
an additional $3 million over the next six years to the
Resuscitation Outcomes Consortium – a landmark
collaborative research initiative funded by HSF and partners.
Results from its ongoing trials are outstanding. The survival
rate in out-of-hospital cardiac arrest in all Canadian sites
has significantly improved due to improved coordinated
resuscitation efforts (see page 39).
The heart and brain are at the core of everything we think and
do. They are the most vital organs – as empowering as they can
be debilitating. It is up to all of us to find a way to protect and
nourish them so we can live better, longer. Thank you for being
part of our vision for a healthy future for Canadians enabled by
life-saving research.
Linda Waverley, PhD
Chair, Research Policy and Planning Advisory Committee
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ACKNOWLEDGEMENTS
1. PURPOSE AND SCOPE
Each year, individuals across Canada join together to further
the Heart and Stroke Foundation (HSF) mission of eliminating
heart disease and stroke. Canadians from coast to coast to
coast donate valuable resources, including their time, money,
and expertise, to improve the health and quality of life of all
Canadians. The following groups deserve special thanks:
The purpose of this report is twofold:
Donors. Providing funds to support heart and stroke research
is the first step in a process which culminates in scientific
breakthroughs that touch all our lives. The donors and volunteers
in every community across Canada that have supported the
Foundation’s fundraising efforts have made lasting investments in
the future health and well being of Canadians.
Research Advisory Committees. Expert and dedicated
members of HSF advisory committees provide critical guidance
for the Foundations’ research endeavour. In particular, the
provincial Research Advisory Committees and the Research Policy
and Planning Advisory Committee (a standing committee of the
HSFC Board) have been instrumental in moving HSF research
efforts forward. The Chairs of these important committees are
listed in Appendix G (page 135).
Scientific Review Committees. The scientific and lay reviewers’
expertise and commitment enable HSF to fund the highest
standard of scientific excellence. Nationally, exemplary
leadership to over 1,000 volunteer reviewers has been provided
by the Scientific Review Committee’s Chair and Vice Chair,
Drs. Balwant Tuana and Todd Anderson, respectively. The Chairs
of HSF’s vital peer review committees across the Federation are
identified in Appendix G (page 135).
1. To illustrate the Heart and Stroke
Foundation’s overall research
investments made in 2008-2009 across
all research funding programs and
initiatives.
2. To serve as a reference tool for
volunteers and staff across the Heart
and Stroke Foundation, the research
community, other research funding
agencies, and academic institutions.
This report covers the period from July 1, 2008 to June 30,
2009. It is a snapshot of expenditures in research during that
period. The report presents financial and statistical data
for new grants and awards made in 2008-2009, as well as
continued funding of previously reported multi-year grants
and awards.
Heart and Stroke Researchers. Each one of HSF’s researchers,
through extraordinary work, contributes to advancements in
the understanding of cardio- and cerebrovascular disease. The
knowledge gained from their efforts leads to earlier diagnoses,
better treatments and new insights into prevention. Their
ongoing commitment to the advancement of knowledge helps
HSF move closer to achieving its mission.
Partners. A number of organizations collaborated with HSF in
2008-2009, enabling the Foundation to leverage funding and
resources for heart and stroke research. The names of our valued
partners can be found throughout the report in section 4
(page 8) and the appendices (page 21).
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2. SUMMARY TABLES
Table 1. Summary Federation-wide and Province-specific Research Funding (2008-2009)
Foundation
Federation-wide Research Initiatives
Grant-in-Aid
#
National
Personnel
Awards
$
#
Province-specific Research Initiatives
Federation
Research Fund
$
#
Personnel
Awards
$
#
Chairs
$
#
Total
Other
$
#
$
#
$
British Columbia/
Yukon
45
4,556,585
-
-
-
-
-
-
3
363,595
1
180,000
49
5,100,180
Alberta/Northwest
Territories/Nunavut
69
3,632,147
-
-
-
-
-
-
4
396,500
1
3,000
74
4,031,647
Saskatchewan
9
425,000
-
-
-
-
5
48,500
-
-
1
100,000
15
573,500
20
865,500
-
-
-
-
8
41,000
-
-
-
-
28
906,500
Ontario
260
23,609,873
-
-
-
- 166
5,374,325
6
264,050 32
9,308,151
464
38,556,398
Quebec
84
1,593,571
-
-
-
-
-
-
-
- 15
130,000
99
1,723,571
8
372,835
-
-
-
-
-
-
-
-
1
47,000
9
419,835
504,475
Manitoba
New Brunswick
11
499,475
-
-
-
-
-
-
-
-
1
5,000
12
Prince Edward Island
Nova Scotia
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Newfoundland and
Labrador
1
40,000
-
-
-
-
-
-
-
-
-
-
1
40,000
All Foundations
-
- 155 4,816,637*
96
3,459,744
-
-
-
-
-
428,571†
251
8,704,953
TOTAL
507 $35,594,986 155 $4,816,637
96 $3,459,744
179 $5,463,825
13 $1,024,145 52 $10,201,722
1,002 $60,561,059
* Includes award stipends, obligatory benefits, and applicable travel allowances.
† HSF contributions to the CSN total $3 million (2007-2013).
Table 2. Detailed Federation-wide and Province-specific Research Funding (2008-2009)
Foundation
Program
British Columbia/Yukon
Grant-in-Aid
Awards (#)
Awards ($)
45
4,556,585
Chair in Cardiology
1
173,346
Chair in Stroke Research
1
107,331
Professorship in Clinical Stroke Research
1
82,918
1
180,000
69
3,632,147
Chair in Cardiovascular Research
1
186,500
Professorship in Stroke Research
2
160,000
Investigatorship in Stroke Rehabilitation Research
1
50,000
Total ($)
Research Chairs*:
Other Provincial Initiatives:
pecial Initiative: CardioSHARE - Cardiovascular Semantic Health and Research
S
Environment
Alberta/
Northwest Territories/
Nunavut
Grant-in-Aid
5,100,180
Research Chairs*:
New Investigator Award
Saskatchewan
1
3,000
9
425,000
Master's Studentship Award
2
35,000
Undergraduate Studentship Award
3
13,500
1
100,000
Grant-in-Aid
4,031,647
Personnel Awards:
Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source
4
573,500
Foundation
Program
Manitoba
Grant-in-Aid
Awards (#)
Awards ($)
Total ($)
20
865,500
Sanofi Aventis/HSFM Award in Cardiology
1
10,000
B.Sc. in Medicine Studentship
3
15,000
Personnel Awards:
Red River College (RRC) Summer Studentship Award
Ontario
4
16,000
260
23,609,873
Chair in Population Health Research
1
0**
Chair in Cardiac Nursing
1
77,722
4
186,328
Grant-in-Aid
906,500
Research Chairs*:
Personnel Awards:
Distinguished Scientist
7
230,000
Career Investigator
34
2,946,325
Clinician Scientist
18
1,195,750
Nursing Post-Doctoral Research Fellowship
1
59,000
Research Fellowship
2
95,000
Master's Studentship
31
558,000
Summer Student Scholarship
73
290,250
Program Grant
5
1,249,828
Stroke Rehabilitation
3
304,950
Age 45+ with Elevated Systolic Blood Pressure
2
562,046
Social Determinants of Hypertension
1
100,085
17
842,581
Pilot Project Grant
Quebec
Operating Grant
1
75,000
HSF Centre for Stroke Recovery
1
5,458,000
HSF/Richard Lewar Centre of Excellence†
1
600,000
Webinar
1
24,000
Publication cost, etc.
-
91,661
84
1,593,571
12
110,000
3
20,000
8
372,835
1
47,000
11
499,475
1
5,000
Grant-in-Aid
38,556,398
Awards for Excellence in Research
Training Bursaries
New Brunswick
Grant-in-Aid
1,723,571
Research Grant
Nova Scotia
Grant-in-Aid
419,835
Dr. Gregory Ferrier Award
504,475
Grant-in-Aid
-
-
-
Newfoundland and
Labrador
Grant-in-Aid
1
40,000
40,000
751
51,856,106
51,856,106
Federation Research Fund
96
3,459,744
3,459,744
National Personnel Awards‡
155
4,816,637
4,816,637
-
428,571
428,571
1,002
$60,561,059
$60,561,059
SUBTOTAL
Canadian Stroke Network•
TOTAL
* For the most part, Research Chair awards are funded by endowments and are partnered with academic / health research institutions.
** Payments from endowed fund temporarily suspended in 2008-2009.
† HSF/Richard Lewar Centre of Excellence - $6 million (1999-2009)
‡ Includes award stipends, obligatory benefits, and applicable travel allowances.
• Combined HSF provincial and national contributions - $3 million (2007-2013)
5
3. R
ESEARCH FUNDING
OVERVIEW
At the provincial level, committee structure varies by province.
Research, budgetary allocation, and peer review committees all
have roles in funding and review of provincial initiatives.
3.1 Research Roles
Members of RPPAC, the SRC Executive, and chairs of provincial
committees for the year 2008-2009 can be found in Appendix G.
Heart and Stroke Foundation of Canada
3.3 Research Enterprise Components
• Manages the peer review for all Grants-in-Aid (GIA).
The HSF research enterprise contains four significant parts
presented in Figure 1. The 10 provincial Foundations invest
over $50 million annually in the Grant-in-Aid program (research
project operating grants); the National Personnel Awards
program (salary awards at doctoral, post doctoral, and new
investigator levels); the Federation Research Fund initiatives
(strategic research initiatives primarily in partnership with other
funding agencies); and provincial research initiatives (personnel
awards, program grants, research chairs and other programs).
Overall funding expenditures for grants and awards have
increased from $44 million to over $60 million over the past five
years (Figure 2).
• Manages peer review and award administration for all
National Personnel Awards.
• Manages peer review and award administration for all aspects
of the Federation Research Fund (FRF) strategic initiatives.
Provincial Heart and Stroke Foundations
• Administer Grants-in-Aid, including funding decisions, award
administration, monitoring and evaluation.
• Manage all aspects, including peer review, of provincespecific research initiatives. An exception is the Heart and
Stroke Foundation of Ontario (HSFO) Career Investigator
program, reviewed by a standing Heart and Stroke
Foundation of Canada (HSFC) subcommittee.
3.2 Scientific Review Process
Figure 1. HSF Research Funding by Program (2008-2009)
Provincial
Research Initiatives
$16,689,692
27%
Grant-in-Aid
$35,594,986
59%
Federation
Research Fund
$3,459,744
6%
Scientific peer review is the cornerstone of the Foundation’s
research enterprise. All research funded by HSF, at a national or
provincial level, undergoes peer review and must meet criteria
for scientific rigor.
National
Personnel Awards
$4,816,637
8%
The Scientific Review Committee (SRC) is responsible for
maintaining a gold standard peer review process for all
applications reviewed through HSFC. The SRC advises the
Research Policy and Planning Advisory Committee (RPPAC),
a HSFC Board standing committee, on matters related to
peer review.
In 2008-2009, over 150 of Canada’s top cardio- and
cerebrovascular scientists participated on the SRC, which
is organized around subcommittees, each having specific
expertise. Collectively the SRC has the ability to expertly review
applications focusing on any health research theme, from basic
biomedical to population health.
HSFC has lay reviewers on subcommittees reviewing GIA and
Senior Personnel Awards applications. The objectives of the lay
reviewer role are to enhance the accountability and integrity of
the HSF peer review process, provide an additional mechanism
for evaluating relevance of projects to the HSF mission, and
increase awareness of the importance of knowledge transfer
and exchange.
6
fig 1 eng
Figure 2. HSF Research Funding Trends by Program
(2004-2009)
ration Research Fund
Federation Research Fund
nal Personnel Awards
2
8
6
4
8
Figure 3. HSF Research Funding by Health Research
Theme (2008-2009)
3.1
4.0
3.7
3.6
3.5
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Clinical
15%
National Personnel Awards
Basic
Biomedical
77%
5.2
4.8
4.6
4.4
4.8
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
-in-Aid
Basic
Population
Biomedical Health 4%
77%
Basic Biomedical
2005-2006
ncial Research Initiatives Provincial Research Initiatives
.9
5.9
2004-2005
Clinical
6.3
6.3
2005-2006
15%
11.6
2006-2007
Health Services/
11.2
2007-2008
Systems 4%
6.7
16.7
2008-2009
Population
Health 4%
Total
2008-2009 60.6
fig
3 eng
2006-2007
fig 3 eng
30.5
33.6
2008-2009
Clinical
2005-2006
6.0
2006-2007
5.7
2007-2008
5.4
2008-2009
44.0
45.1
51.0
50.6
29.3
31.1
2007-2008
6.7
Health Services/Systems
60.6
2005-2006
1.9
2006-2007
1.6
2007-2008
1.4
2008-2009
1.6
air values for† years
2006-2007,
andfor
2008-2009
only.
Includes
Research2007-2008,
Chair values
years 2006-2007,
2007-2008, and 2008-2009 only.
Population Health
3.4 Investments across Health Research Themes
fig 2 eng
Research supported by HSF spans the four health research
fig 3 themes:
eng basic biomedical, clinical, health services/systems, and
population health (defined in Appendix H).
Figures 3 and 4 show the relative HSF investments across health
research themes. Overall, HSF research has traditionally been
2005-2006
2006-2007
2007-2008
2008-2009
Hea
Syst
P
H
Numbers represent $ Millions
†
44.0
2004-2005
45.1
2005-2006
51.0
2006-2007
50.6
2007-2008
Health Services/
Systems 4%
Figure 4. HSF Research Funding Trends by Health
Research Theme (2005-2009)
29.8
30.0
31.1
31.4
35.6
†
Basic
Biomedical
77%
Clinical
15%
Includes Federation Research Fund, National Personnel Awards (stipends only),
and Grant-in-Aid funding.
Grant-in-Aid
29.8 2004-2005
30.0 2005-2006
31.1 2006-2007
31.4 2007-2008
35.6
2008-2009
concentrated heavily in the basic biomedical sciences (Figure 4).
Further in the report, funding by health research theme in each
of the federation-wide programs is presented. Currently, we do
not have data on provincial initiatives by theme.
1.4
1.6
1.4
1.9
Includes Federation Research Fund, National Personnel Awards (stipends only),
and Grant-in-Aid funding.
fig 4 eng
7
4. 2
008-2009 RESEARCH
FUNDING BY PROGRAM
This section provides summary information for each of the four
main components of the HSF research enterprise:
Federation-wide research programs:
1. Federation Research Fund
2. National Personnel Awards
3. Grant-in-Aid
4. Province-specific research initiatives:
i. Provincial Research Chairs
ii. Provincial Personnel Awards
iii. Other Provincial Research Initiatives
4.1 Federation Research Fund
The Federation Research Fund (FRF) supports research in areas
of strategic priority to HSF, typically through a Request for
Applications process, and in partnership with other agencies
and organizations.
New initiatives appearing in this year’s report include:
1) S
econdary Stroke Prevention Health Services and Care.
These Team Grants support research that examines how to
improve the timely delivery of secondary stroke prevention
health services and care. The initiative encourages active
linkages between stroke researchers and knowledge users.
The goal is to help advance the Canadian Stroke Strategy
by furthering research with the potential to contribute to
ensuring optimal outcomes for stroke patients.
2) V
ascular Cognitive Impairment. This strategic initiative aims
to address the roles of small vessel disease and stroke in
cognitive impairment. Projects are multidisciplinary and have
the potential to impact clinical practice and significantly
advance knowledge in this important area.
3) F
ocus on Stroke 7. This initiative, led by HSF, supports
doctoral students and postdoctoral fellows working in
the area of stroke. The goal is to build greater capacity
for stroke research in Canada and to support the next
generation of stroke researchers.
8
4) Novel and Exploratory Research Fund 2009. This special
competition provides one-year funding for novel and
exploratory research that has the potential for momentous
impacts on heart disease and stroke. Only the two top rated
applicants from each of the Scientific Review Subcommittees
are invited to apply. The proposals must have paradigmshifting potential to be competitive.
5) Intervention Research - Healthy Living and Chronic Disease
Prevention. The focus of this initiative is intervention and
evaluation research on “natural experiments” - rapidly
unfolding programs, events, policy initiatives/changes - that
have the potential to impact healthy living and/or address
chronic disease prevention.
6) Childhood Obesity Prevention and Treatment. This
program is aimed at intervention research in the area of
childhood obesity. The goal is to advance knowledge to
prevent and treat childhood obesity in clinical settings or
at the population level and to increase the speed at which
evidence is transferred into practice.
7) Applied Public Health Chair. This strategic initiative
supports research into risk factors for chronic diseases and
their underlying determinants from a population health
perspective. Funded programs are integrated platforms that
engage researchers, trainees, practitioners, and knowledge
users in collaborative action to prevent chronic diseases and
promote and improve health. HSF is co-funding one Applied
Public Health Chair in the area of obesity.
The majority of the projects listed in Appendix A represent
the continuation of previously reported research investments.
A total of 29 initiatives (representing 96 individual grants and
awards) are detailed in Appendix A.
The total value of HSF’s investment in these projects for 20082009 is over $3.4 million. In addition to HSF’s investment,
partner funds have further extended the FRF research
investments. As outlined in Figure 5, HSF funding is leveraged
by a ratio of almost two to one. The Foundation has partnered
with numerous organizations since the FRF began, including all
of the Canadian Institutes of Health Research (CIHR) Institutes,
the Canadian Stroke Network, other health charities (e.g., The
Kidney Foundation of Canada, Canadian Diabetes Association)
and industry (e.g., AstraZeneca Canada, Pfizer Canada) to
maximize research dollars in areas of common interest.
Figure 5. Federation Research Fund Leveraged Funding
(2004-2009)
Figure 7. Federation Research Fund Funding Trends by
Health Research Theme (2005-2009)
2004-2005
2005-2006
edical 29%
2006-2007
2007-2008
Population
Health 29%
2008-2009
3.1
11.0
HSFC
Partner(s)
4.0
13.3
Clinical 21%
Basic Biomedical
3.7
2005-2006
2006-2007
2007-2008
2008-2009
3.6
9.2 Services/
Health
Systems 21%
3.5
6.9
One of the objectives of the FRF is to support interdisciplinary
research in the areas of health services/systems and population
health. Figures 6 and 7 show a fairly balanced distribution of
funds across health research themes. It is important to note,
however, that the Federation Research Fund represents less
than 10% of overall HSF research investment.
Figure 6. Federation Research Fund Funding by Health
5 eng
engfig
1.0
1.0
1.0
Population 0.7
Health 29%
2005-2006
2006-2007
2007-2008
2008-2009
Clinical 21%
Clinical 21%
Health Services/
Systems 21%
Health Services/
Systems 21%
1.0
0.7
0.7
0.7
Population Health
2005-2006
2006-2007
2007-2008
2008-2009
0.8
0.8
0.6
1.0
Basic Biomedical
fig 6 eng
4.2 National
Population
Health 29%
1.0
Clinical
11.9
Basic
Biomedical 29%
1.2
1.2
1.3
2005-2006
2006-2007
2007-2008
Basic
2008-2009
Biomedical 29%
1.2
1.2
1.3
2005-2006
2006-2007
Personnel
Awards
2007-2008
2008-2009
1.0
National Personnel Awards build Canada’s cardio- and
cerebrovascular research capacity
by providing salary support
Clinical
to investigators at early
scientific
career
stages. The 2008-2009
1.0
2005-2006
programs included New
Investigator, Research Fellowship,
1.0
2006-2007
1.0 and
2007-2008
Doctoral Research Award,
Nursing Research Fellowship,
0.7
2008-2009
Visiting Scientist.
fig 7 eng
2005-2006
2006-2007
2007-2008
2008-2009
1.0
0.7
0.7
0.7
Population Health
fig 6 eng
2005-2006
2006-2007
2007-2008
2008-2009
fig 7 eng
0.8
0.8
0.6
1.0
9
In 2008-2009, 155 new and continuing awards were funded. This
included 9 awards supported in part by industry. The total HSF
investment in National Personnel Awards in 2008-2009 was over
$4.8 million (Table 3). A list of award recipients can be found in
Appendix B.
National Personnel Awards Programs in 2008-2009
New Investigator — A salary award to support new
investigators who wish to establish their own independent research laboratory ($60,000 per year for five
years, including fringe benefits).
Table 3. Number of National Personnel Awards and
Investment of Funds (2008-2009)
Research Fellowship — A training award for applicants
who have completed a professional degree, MD or
PhD (up to $50,000 per year for two to three years).
Program
Doctoral Research Award — A training award for
graduate students, enrolled in a PhD program, who
are undertaking full-time research training ($21,000
per year for up to three years).
Recipients (#)
New Investigator
33
1,731,603
Research Fellowship
61
1,887,331
Doctoral Research Award
53
931,176
Nursing Research Fellowship
7
156,250
Visiting Scientist
1
14,500
Obligatory Benefits
-
14,000
Travel Allowance
Nursing Research Fellowship — A training award for
nursing researchers enrolled in an MSc/MA, PhD, or
research fellowship program ($25,000 per year for up
to three years).
Funds Invested ($)
TOTAL
-
81,778
155
$4,816,637
Table 4 highlights the distribution of National Personnel Awards
by health research theme. In 2008-2009, the majority of awards
were in the basic biomedical area (84%). This is consistent with
previous years (Figures 8 and 9).
Visiting Scientist — A salary/travel award that enables
established investigators who visit another institution
to develop and share research expertise.
Table 4. HSF National Personnel Awards by Health Research Theme (2008-2009)
Type of Award
Basic Biomedical
(#)
Clinical
($)
(#)
($)
(#)
($)
Population Health
(#)
Total
($)
(#)
($)
New Investigator
28.4
1,514,269
4.1
187,333
-
-
0.6
30,000
33.0
1,731,603
Research Fellowship
54.3
1,634,506
6.0
224,825
0.1
4,000
0.6
24,000
61.0
1,887,331
47.3
823,201
5.1
96,775
0.2
2,625
0.5
8,575
53.0
931,176
0.2
1,562
3.8
83,750
2.4
56,354
0.7
14,583
7.0
156,250
-
-
1.0
14,500
-
-
-
-
1.0
14,500
130.1
$3,973,538
19.9
$607,184
2.7
$62,979
2.4
$77,158
155.0
$4,720,859
Nursing Research Fellowship
Visiting Scientist
TOTAL
Includes award stipends only.
10
Figure 8. National Personnel Awards Funding by Health
Basic Biomedical
4.0
4.2
Clinical
13 %
4.0
Health 3.7
Services/
4.0
Systems 1%
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Clinical
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
0.7
0.6
0.4
0.5
0.6
35 Clinical
0.7
2004-2005
8
0.6
2005-2006
2006-2007 40 0.4
Alta./N.W.T./Nunavut
0.5
122007-2008
0.6
2008-2009
Sask.
Que.
2004-200537
6 2005-2006
2006-2007
N.B. 0 2007-2008
Applications
0 Submitted
2008-2009
Applications Funded
N.S. 5
351
B.C./Yukon
8
P.E.I. 0
040
12
N.L. 0
4
0
Sask.
1
20
Canadians studying abroad
6
Man. 10
2
fig 8 eng
0.7
0.6
0.4
0.5
0.6
0.1
0.1
0.1
0
0.1
99
Ont.
Population Health
26
fig 10 eng
37
Que.
0.2
0.2
0.1
0.1
0.1
6
N.B. 0
0
5
N.S.
There is a wide variation by province in applications
submitted and funded. Very few National Personnel Awards
applications are funded in the Atlantic provinces, Manitoba,
and Saskatchewan (Figure 10). The overall success rate for the
National Personnel Awards competitions in 2008-2009 was
approximately 25%.
fig 9 eng
0.2
0.2
0.1
0.1
0.1
fig 9 eng
fig 9 eng
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
0.1
0.1
0.1
0
0.1
99
Population Health
Population Health
Basic Biomedical
0.2
2004-2005
4.0
0.2
2005-2006
4.2
0.1
2006-2007
4.0
0.1
2007-2008
3.7
0.1
2008-2009
4.0
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
4
1
2004-2005
Man. 10 2005-2006
2 2006-2007
2007-2008
2008-2009
Ont.
26
by
Clinical
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
4.0
3.7
4.
B.C./Yukon
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
4.
2006-2007
2007-2008 Submitted
Applications
2008-2009 Funded
Applications
Population
Health 2%
Basic
Biomedical
84%
2004-2005
0.1
Includes award stipends only.
2005-2006
0.1
2006-2007
0.1
Figure 9. National Personnel
Awards Funding Trends
2007-2008
Health Research Theme0(2004-2009)
2008-2009
0.1
Figure 10. Number of National Personnel Award
Basic Biomedical
Applications Submitted and Funded by Province/
2004-2005
represent $ Millions
Territory (2008-2009) Numbers
2005-2006
1
P.E.I. 0
0
N.L. 0
0
20
Canadians studying abroad
6
11
4.2.1 Heart and Stroke Foundation Prestigious Awards
4.3 Grant-in-Aid
Each year, two outstanding New Investigators are recognized
for their scientific excellence through the following prestigious
HSFC awards. Recipients are awarded a $15,000 research grant
(in addition to the $60,000 New Investigator award stipend).
Grants-in-Aid (peer-reviewed nationally, and funded and
administered provincially) are the largest category of research
expenditure for the Heart and Stroke Foundation. The Grant-inAid program supports the direct operating costs of conducting
research, including laboratory supplies, technicians, and some
equipment. Grant amounts vary, but typically range from
$10,000 to a maximum of $210,000 per year.
McDonald Scholarship
The McDonald Scholarship award is named in honour of Ewing
McDonald, the Heart and Stroke Foundation of Canada’s
Executive Director from 1968 to 1987. This award is given
annually to the highest-rated applicant in the New Investigator
program. Dr. Christopher Ahern, of the University of British
Columbia, was the Heart and Stroke Foundation’s 2008-2009
McDonald Scholar. Dr. Ahern ‘s research is focused on the root
causes of cardiac arrhythmia. Drugs used for arrhythmia prevent
the heart cells from misfiring but scientists don’t know the
details of why or how. Understanding what is going on at the
cellular level will help tailor treatments for cardiac arrhythmia.
Henry J.M. Barnett Scholarship
The Henry J.M. Barnett Scholarship award was established to
honour Dr. Henry J.M. Barnett’s exceptional contributions to
stroke research, education, and patient care in Canada. This
award is presented annually to a highly rated New Investigator
applicant working in stroke research. Dr. Roger Thompson, of
the University of Calgary, was the Heart and Stroke Foundation’s
2008-2009 Barnett Scholar. Dr. Thompson’s research has added
another critical piece to understanding that necrosis – the rapid
death of brain cells – is not just the blood-starved brain going
haywire, but a programmed pattern of events. Having identified
pannexin-1 as crucial to the cell-death process, the long-term
goal of Dr. Thompson’s research is to establish pannexin-1 as a
target for new drugs to stop cell death when stroke hits.
12
In 2008-2009, 507 Grants-in-Aid (new and continuing) were
funded, representing an investment of over $35.5 million (Table
5). A list of grant recipients can be found in Appendix C.
Table 5. Number of Grants-in-Aid and Investment of
Funds (2008-2009)
Foundation
Recipients (#)
Funds Invested ($)
45
4,556,585
Alberta/Northwest
Territories/Nunavut
69
3,632,147
9
425,000
20
865,500
Ontario
260
23,609,873
Quebec
84
1,593,571
8
372,835
Saskatchewan
Manitoba
New Brunswick
11
499,475
Prince-Edward-Island
Nova Scotia
-
-
Newfoundland and
Labrador
1
40,000
507
$35,594,986
TOTAL
Grants-in-Aid are heavily concentrated ($28.6 million or 80% of
overall expenditure) in the basic biomedical sciences (Figures
11 and 12).
Figure 11. Grant-in-Aid Funding by Health Research
Theme (2008-2009)
Clinical
15 %
Health
Services/
Systems 2%
Population
Health 3%
Basic
Biomedical
80%
Figure 12. Grant-in-Aid Funding Trends by Health
Basic Biomedical
24.6
2004-2005
24.0
2005-2006
Again, as in the National
Personnel Awards competitions, the
25.3
2006-2007
26.1
2007-2008
number of applications submitted and funded in the Grant28.6
2008-2009
in-Aid program varies widely across provinces (Figures 13 and
14). The average Grant-in-Aid amount invested in 2008-2009
Clinical
was approximately $70,207 with Ontario supporting the largest
4.5
2004-2005
grant amount ($195,550).
The overall success
rate for the Grant4.5
2005-2006
in-Aid competition in 2008-2009
4.3
2006-2007 was 44%.
2007-2008
2008-2009
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
0.6
0.9
0.9
0.7
0.7
Population Health
Basic Biomedical
24.6
24.0
25.3
26.1
28.6
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
3.9
5.3
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
0.3
0.6
0.7
0.7
0.9
fig 11 Clinical
eng
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
4.5
4.5
4.3
3.9
5.3
0.6
0.9
0.9
0.7
0.7
Population Health
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
0.3
0.6
0.7
0.7
0.9
fig 12 eng
Numbers represent $ Millio
B.C./Yukon
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
44
40
40
38
46
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
52
48
45
47
55
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Sask.
12
8
7
5
8
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Man.
23
10
14
17
15
Ont.
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Que.
fig 12 eng
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
63
64
51
53
39
N.B.
2004-2005 2
2005-2006 0
2006-2007 4
13
Figure 13. Number of Grant-in-Aid Applications
Submitted by Province/Territory (2004-2009)
present $ Millions
n
B.C./Yukon
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
T./Nunavut
4
Figure 14. Number of Grant-in-Aid Applications Funded
by Province/Territory (2004-2009)
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
44
40
40
38
46
B.C./Yukon
15
16
19
13
11
B.C./Yukon
15
16
19
13
11
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
52
48
45
47
55
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Sask.
12
8
7
5
8
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Sask.
6
4
4
2
5
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Sask.
6
4
4
2
5
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Man.
23
10
14
17
15
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Man.
18
4
8
9
7
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Man.
18
4
8
9
7
Ont.
2004-2005 214
2005-2006 207
2006-2007201
226
2007-2008
2008-2009 215
Que.
63
64
51
53
29
30
32
29
23
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
39
N.L.
2
3
1
1
0
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
N.L.
2
3
1
1
0
35
23
28
25
20
1
95
95
1
Que.
29
30
32
29
23
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
N.B.
N.S.
15
9
10
11
17
P.E.I.
2004-2005
1
2004-2005
2005-2006
3
2005-2006
2006-2007
0
2006-2007
2007-2008
0
2007-2008
2008-2009
0
2008-2009
14
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
Ont.
2004-2005 102
2005-2006 104
2006-2007 95
2007-2008 95
2008-2009 103
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
N.B.
2004-2005 2
2005-2006 0
2006-2007 4
2007-2008 2
2008-2009 3
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
23
28
25
20
Ont.
214
207
201
226
215
Que.
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
35
N.B.
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
1
0
2
2
1
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
N.S.
9
2
4
4
5
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
2004-2005
2005-2006
2006-2007
2007-2008
2008-2009
P.E.I.
0
0
0
0
0
P.E.I.
2004-2005
0
2004-2005
2005-2006
0
2005-2006
2006-2007
0
2006-2007
2007-2008
0
2007-2008
2008-2009
0
2008-2009
2004-2005 1
2005-2006 0
2006-2007 2
2007-2008 2
2008-2009 1
N.S.
9
2
4
4
5
N.L.
1
0
1
0
0
20042005200620072008-
4.4 Province-specific Research Initiatives
In addition to the Grant-in-Aid program, many of the provincial
Foundations administer Research Chairs, Professorships, and
Investigatorships; provincial Personnel Awards; and other
research initiatives.
4.4.1 Research Chairs, Professorships, and
Investigatorships
Also in 2008/2009, Dr. Sonia Anand was appointed as the
inaugural chair holder of the Heart and Stroke Foundation of
Ontario / Michael G. DeGroote Chair in Population Health
Research at McMaster University. With her colleagues, Dr.
Anand is undertaking research initiatives that include a project
uncovering community level determinants of obesity in
Aboriginal communities, and a project to learn why South Asians
develop high rates of abdominal obesity and Type 2 diabetes.
Research Chair funding provides salary and infrastructure
support to enable a leading researcher to develop a particular
research focus at a Canadian university. In 2008-2009 a total
of 14 Chairs, Professorships, and Investigatorships were
supported by HSF in the areas of cardiology, stroke, cardiac
nursing, obesity, and population health. This represents an
investment of over $1 million (see Table 6). The recipients of
these Chairs, Professorships, and Investigatorships can be
found in Appendix D.
Table 6. Research Chairs, Professorships, and Investigatorships (2008-2009)†
Foundation
Program
Chair in Cardiology
Awards (#)
Awards ($)
Total ($)
1
173,346
1
107,331
Professorship in Clinical Stroke Research
1
82,918
Alberta/Northwest Territories/Nunavut Chair in Cardiovascular Research
1
186,500
363,595
Professorship in Stroke Research
2
160,000
Investigatorship in Stroke Rehabilitation
Research
1
50,000
396,500
Saskatchewan
-
-
-
-
Manitoba
-
-
-
-
Ontario
Chair in Population Health Research
1
0*
Chair in Cardiac Nursing
1
77,722
4
186,328
264,050
Quebec
-
-
-
-
New Brunswick
-
-
-
-
Nova Scotia
-
-
-
-
-
-
-
-
Newfoundland and Labrador
-
-
-
-
HSFC
Chair in Applied Public Health Research
1
0**
0**
14
$1,024,145
$1,024,145
TOTAL
† For the most part, Research Chair awards are funded by endowments and are partnered with academic/health research institutions.
* Payments from endowed fund temporarily suspended in 2008-2009.
** Funding from partner organizations began in 2007/2008; Heart and Stroke Foundation funding will begin in 2009/2010.
15
4.4.2 Provincial Personnel Awards
In 2008-2009, the provincial Foundations funded a total of 179 Personnel Awards, building capacity by supporting cardio- and
cerebrovascular researchers throughout their careers, from high school students working in research settings to established senior scientists
(Table 7). The recipients of these awards can be found in Appendix E.
Table 7. HSF Provincial Personnel Awards Funded (2008-2009)
Foundation
Program
-
-
-
-
Alberta/Northwest Territories/Nunavut
-
-
-
-
Saskatchewan
Master's Studentship Award
2
35,000
3
13,500
Manitoba
Sanofi Aventis/HSFM Award in Cardiology
1
10,000
3
15,000
Ontario
Awards (#)
Awards ($)
Total ($)
Red River College (RRC) Summer Studentship
Award
4
16,000
Distinguished Scientist
7
230,000
Career Investigator
34
2,946,325
Clinician Scientist
18
1,195,750
Nursing Post-Doctoral Research Fellowship
1
59,000
Research Fellowship
2
95,000
48,500
41,000
Master's Studentship
31
558,000
Summer Student Scholarship
73
290,250
5,374,325
Quebec
-
-
-
-
New Brunswick
-
-
-
-
Nova Scotia
-
-
-
-
-
-
-
-
-
TOTAL
16
-
-
-
179
$5,463,825
$5,463,825
Description of Provincial Personnel Awards
Heart and Stroke Foundation of Saskatchewan (HSFS)
Master’s Studentship Award — A training award for graduate
students enrolled in a Master’s program who are taking fulltime research training. The award is for $17,500 per year for up
to two years.
Undergraduate Studentship Award — A training award for
students enrolled in a full-time undergraduate program who
are interested in pursuing research. The award is for $4,500
for a maximum of 16 consecutive weeks on a full-time basis
beginning May 1st and ending August 31st.
Heart and Stroke Foundation of Manitoba (HSFM)
Sanofi Aventis / Heart and Stroke Foundation of Manitoba
Award in Cardiology — This $10,000 award is given to
stimulate and support excellence in research and scholarly
activity in the discipline of Cardiology at the University of
Manitoba. The award funds a clinical cardiology resident,
preferably in their third year, who demonstrates academic
excellence within the clinical residency program, possesses
humanistic qualities with respect to patient care, collegiality
and interpersonal dealings with medical and paramedical staff,
has clinical competence in the field, and is expected to pursue
further academic training beyond core cardiology.
B.Sc. in Medicine Studentship — The Summer Research
Studentships in Medicine support individuals in the Bachelor
of Science in Medicine Program while working with senior
researchers during the summer months.
Red River College (RRC) Summer Studentship Award — The
Red River College Summer Studentship awards support top tier
students in the Chemical and Biosciences Technology program
to assist them in securing cooperative work terms with medical
researchers during the summer months.
Heart and Stroke Foundation of Ontario (HSFO)
Distinguished Scientist:
•M
aureen Andrew New Investigator Award — Supplementary
funding for one year for the highest rated Ontario-based New
Investigator.
Career Investigator — Stipend support for up to five years for
investigators of national/international stature.
Clinician Scientist Phase 1 — Stipend support for up to three
years for junior healthcare clinicians where no more than three
years have elapsed since their first academic appointment.
Clinician Scientist Phase 2 — Stipend support for up to three
years for healthcare clinicians where no more than seven years
have elapsed since their first academic appointment.
Nursing Post-Doctoral Research Fellowship — Stipend
support for up to three years for nurses intending to undertake
independent research programs.
Research Fellowship — Stipend support for between two and
six years for investigators focusing on research related to either
stroke or women, heart disease and stroke.
Master’s Studentship — Stipend support for up to two years
for highly qualified individuals to undertake full-time research
training under an academic supervisor.
Summer Student Scholarship:
• Medical Student Award — Stipend support for up to four
months for medical students to work with established
investigators conducting research.
• J ohn D. Schultz Science Student Scholarship — Stipend
support for three months for undergraduate students to
undertake a research project with a supervisor at a university
or hospital.
• Martin L. Wills High School Scholarship — Stipend support
for two months for secondary students to undertake a
research project with a supervisor at a university or hospital.
• Rick Gallop Award for Research Excellence — The five
highest rated Ontario Grant-in-Aid recipients are eligible to
compete for a supplementary grant for an innovative, “outof-the-box” research project.
• Sifton Distinguished Scientist Award — Supplementary
funding for five years for the highest rated Career Investigator
at the University of Toronto.
• Fortino’s Distinguished Scientist Award — Supplementary
funding for five years for the highest rated Career Investigator
at McMaster University.
17
4.4.3 Other Provincial Initiatives
In 2008-2009, the provincial Foundations funded a wide variety of other research initiatives. Table 8 provides details of these initiatives
and recipients can be found in Appendix F.
Table 8. Other Provincial Research Initiatives (2008-2009)
Foundation
Program
Awards (#)
Awards ($)
Special Initiative: CardioSHARE - Cardiovascular Semantic Health
and Research Environment
1
180,000
180,000
1
3,000
3,000
Saskatchewan
Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian
Light Source
1
100,000
100,000
Manitoba
-
-
-
-
Ontario
Program Grant
5
1,249,828
3
304,950
2
562,046
1
100,085
17
842,581
Operating Grant
1
75,000
HSF Centre for Stroke Recovery
1
5,458,000
HSF/Richard Lewar Centre of Excellence†
1
600,000
Webinar
1
24,000
Pilot Project Grant
Publication cost, etc.
Total ($)
-
91,661
12
110,000
Training Bursaries
3
20,000
130,000
New Brunswick
Research Grant
1
47,000
47,000
Nova Scotia
Dr. Gregory Ferrier Award
1
5,000
5,000
-
-
-
-
-
Quebec
Awards for Excellence in Research
Canadian Stroke Network‡
TOTAL
9,308,151
-
-
-
-
428,571
428,571
52 $10,201,722
$10,201,722
† HSF/Richard Lewar Centre of Excellence - $6 million (1999-2009)
‡ Combined HSF provincial and national contributions - $3 million (2007-2013)
Description of Other Provincial Research Initiatives
Heart and Stroke Foundation of British Columbia & Yukon
(HSFBCY)
Special Initiative: CardioSHARE - Cardiovascular Semantic
Health and Research Environment — HSFCBY invested
$360,000 over two years (March 1, 2007 to February 28, 2009) to
develop a data search, classification, and management system
for ischemic heart disease.
Heart and Stroke Foundation of Alberta, NWT & Nunavut
(HSFA)
New Investigator Award — This award is provided annually to
applicants who choose a Canadian Institutes of Health Research
(CIHR) operating grant instead of an HSFA award for the same
Grant-in-Aid project. Applicants must be within the HSFA cut-off
score for the year and must fall under the New Investigator
18
category (i.e. within five years of faculty appointment). It is
hoped that supporting new investigators will help HSFA to
establish future relationships with the up-and-coming heart
and stroke researchers of Alberta. The award supports the
new investigator’s travel to meetings, conferences, seminars,
or workshops relating to the specific research funded by CIHR;
or professional growth in the broad research area. Either
the Principal Investigator (PI), or his/her designates including
trainee(s) at any level can receive this benefit.
Heart and Stroke Foundation of Saskatchewan (HSFS)
Biomedical Imaging and Therapy (BMIT) Beamline at the
Canadian Light Source — Located at the University of
Saskatchewan, the Canadian Light Source is Canada’s national
centre for synchrotron research. The BMIT beamline is a
powerful new tool for the imaging, study and treatment
of disease. This facility is funded through a broad-based
partnership of supporters, including HSFS.
Heart and Stroke Foundation of Ontario (HSFO)
Program Grants — These grants provide support for teams of
three or more investigators engaging in collaborative, multidisciplinary research in the fields of cardio- and cerebrovascular
disease in Ontario institutions.
Stroke Rehabilitation — This Request for Applications was
geared to multi-institute, multi-disciplinary, collaborative
applications to support research into stroke rehabilitation.
Age 45+ with Elevated Systolic Blood Pressure — To better
understand this area, HSFO launched a research competition
focused on managing elevated systolic blood pressure in
individuals aged 45 years and older.
Social Determinants of Hypertension — Through this
competition, multi-disciplinary, collaborative applications were
sought focusing on identifying the less well understood social
determinants of hypertension.
Pilot Project Grants — Small operating grants intended to
enable investigators to generate preliminary data, validate
methodologies or test hypotheses that will lead to subsequent
success of recipients in the Foundation’s open competitions.
Operating Grant — This grant supports the direct operating
costs of conducting research, including laboratory supplies,
technicians, and some equipment.
Heart and Stroke Foundation Centre for Stroke Recovery —
A virtual centre of excellence with scientists in Ottawa and
Toronto working collaboratively across the entire spectrum
of molecular studies, laboratory models, human clinical trials,
cognitive evaluation, and imaging modalities. The Centre’s
mandate is to improve recovery from stroke through the
discovery, mobilization and testing of brain repair.
Heart and Stroke/Richard Lewar Centre of Excellence in
Cardiovascular Research — Focused on the prevention and
cure of atherosclerosis, heart failure and congenital heart
disease. From this research will evolve diagnostic, prognostic,
and therapeutic innovations that can impact on the health of
all Canadians.
Webinar — “Health Services and Population Health Grants:
Tips for Successful Applications” An online resource designed
to support health services and population health investigators
in developing successful grant applications.
Publication Costs — HSFO reimburses grant recipients for
costs related to publications resulting from work completed
during the granting period.
Heart and Stroke Foundation of Quebec (HSFQ)
Awards for Excellence in Research — A number of Awards
for Excellence in Research are awarded each year by HSFQ
in partnership with individual and corporate donors. These
awards enhance the Grant-in-Aid program and provide
additional financial support to Quebec researchers. The
awards range from $5,000 to $20,000.
Training Bursaries for PhD students in Cardiovascular and
Stroke Research — Partnership between the Fonds de la
recherche en santé du Québec (FRSQ), the Réseau en santé
cardiovasculaire (RSCV) and the Heart and Stroke Foundation
of Québec (HSFQ). The partners offer training bursaries for
PhD students working with researchers receiving a Grant-in-Aid
from the Heart and Stroke Foundation of Québec (HSFQ).
Heart and Stroke Foundation of New Brunswick (HSFNB)
Research Grant — HSFNB provides funding for one research
project in the area of cardiac rehabilitation.
Heart and Stroke Foundation of Nova Scotia (HSFNS)
Dr. Gregory Ferrier Award — HSFNS offers an award of
excellence in research. This award is given annually to the
highest rated HSFNS Grant-in-Aid recipient in honour of Dr.
Gregory Ferrier, an internationally respected, award-winning
scientist known for his groundbreaking and innovative research
program related to heart failure mechanisms. The award
also honours the spirit of Dr. Ferrier’s mentorship to a new
generation of researchers; he went above and beyond to
ensure they were able to conduct their research in Nova Scotia.
A stipend of $5,000 is awarded to the grant budget in support
of student funding in recognition of Dr. Ferrier’s commitment to
research training.
19
APPENDIX
A
FEDERATION RESEARCH FUND
Photo: Dr. Ron Buliung and Dr. Guy Faulkner (University of Toronto) lead a team funded in 2008-2009 through an award titled “Built Environment and
Active Transport (BEAT)”. The award is part of the Federation Research Fund’s Built Environment, Obesity and Health 2007 initiative.
Explanatory Notes
1. The year following the initiative title indicates the year in which funding began for that initiative.
2. T
erm refers to the number of years of funding received by the projects. These years do not necessarily correspond to the calendar
year or HSF’s fiscal or funding year, but are based on the start date of the projects.
3. The funding ratio is the ratio of HSF funding to partners’ funding.
4. S
ome projects that did receive funding directly from HSF were included based on the partnership details of the specific initiative. HSF
was recognized in some instances as a funder for all projects supported through the initiative regardless of level of contribution.
Acronym
Full name of organization
ACB.......................................................Alberta Cancer Board
APQ......................................................Association pulmonaire du Québec
AstraZeneca.........................................AstraZeneca Canada Inc.
BCCA....................................................British Columbia Cancer Agency
CCMB...................................................Cancer Care Manitoba
CCS.......................................................Canadian Cardiovascular Society
CDA......................................................Canadian Diabetes Association
CIHR......................................................Canadian Institutes of Health Research
CIHR-Ethics..........................................CIHR Ethics Office
CIHR-GHRI...........................................CIHR Global Health Research Initiative
CIHR-HIV/AIDS....................................CIHR HIV/AIDS Research Initiative
CIHR-KT................................................Canadian Institutes of Health Research - Knowledge Translation Branch
CIHR/Rx&D...........................................CIHR/Rx&D Collaborative Research Program
CLA.......................................................Canadian Lung Association
CPHI......................................................Canadian Population Health Initiative
CRPO....................................................Centre de recherche pour la prévention de l’obésité
CSN.......................................................Canadian Stroke Network
CTCRI....................................................Canadian Tobacco Control Research Initiative
DRDC....................................................Defence Research and Development Canada
HC.........................................................Health Canada
HSF.......................................................Heart and Stroke Foundation
IA...........................................................CIHR Institute of Aging
IAPH......................................................CIHR Institute of Aboriginal Peoples’ Health
ICR........................................................CIHR Institute of Cancer Research
22
Acronym
Full name of organization
ICRH......................................................CIHR Institute of Circulatory and Respiratory Health
IG..........................................................CIHR Institute of Genetics
IGH........................................................CIHR Institute of Gender and Health
IHDCYH................................................CIHR Institute of Human Development, Child and Youth Health
IHSPR....................................................CIHR Institute of Health Services and Policy Research
III............................................................CIHR Institute of Infection and Immunity
IMHA.....................................................CIHR Institute of Musculoskeletal Health and Arthritis
INMD....................................................CIHR Institute of Nutrition, Metabolism, and Diabetes
INMHA..................................................CIHR Institute of Neurosciences, Mental Health, and Addiction
IPPH......................................................CIHR Institute of Population and Public Health
NCIC.....................................................National Cancer Institute of Canada
NHLBI...................................................National Institutes of Health - National Heart Lung and Blood Institute
Pfizer.....................................................Pfizer Canada Inc.
PHAC....................................................Public Health Agency of Canada
SCN.......................................................Stem Cell Network
Tekes.....................................................Finnish Funding Agency for Technology and Innovation
23
NEW INITIATIVES
Secondary Stroke Prevention Health Services and Care Team Grants 2009
Partners: HSF (lead), ICRH, IA, CSN.
Total Initiative Funding: $1,797,967
HSF Total Initiative Funding: $1,197,967
Description: This strategic initiative seeks to advance the goals of the Canadian Stroke Strategy, by funding research that examines how
to improve the timely delivery of secondary stroke prevention services and care that will ensure optimal outcomes for patients.
Secondary Stroke Prevention Health Services and Care Team Grants 2009
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
Coutts,
Shelagh B.;
Jeerakathil,
Thomas J.
Alberta Stroke
Prevention in TIAs
and mild strokes
(ASPIRE).
Alberta: Butcher, Ken S.;
Demchuk, Andrew M.;
Edmond, Cathy; Majumdar,
Sumit R.; Shuaib, Ashfaq;
Watson, Timothy J.
20092012
66,676
100,010 400,046
600,046
II,III
MacKayDalhousie
Lyons, Marilyn University
J.; Gubitz,
Gordon J.
Program of
Rehabilitative
Exercise and
Education to avert
Vascular Events
after Non-disabling
stroke or Transient
ischemic attack
(PREVENT trial).
Nova Scotia: Bedard, Richard
J.; Blanchard, Chris M.;
Corning, Corinne; DeWolfe,
Judy M.; Eskes, Gail A.; Firth,
Wanda; Giacomantonio,
Nicholas B.; MacKay,
Michelle; Maharaj, Mandat;
Manley, Sarah; Skedgel, Chris;
Thompson, Kara; Marsters,
David; Wightman, Howard.
20092012
66,661
99,994 399,146
599,146
II,III
Penn,
Andrew M.
W.; Maclure,
Malcolm
A natural
experiment in
rapid TIA care with
knowledge transfer
and exchange.
British Columbia: Harris,
Devin R.
20092012
69,807
103,140 398,775
598,775
II,III,IV
University
of Calgary
Vancouver
Island
Health
Authority
*Amount may change depending on circumstances
24
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
Novel and Exploratory Research Fund 2009
Partner(s): HSF (lead).
Total Initiative Funding: $100,000
HSF Total Initiative Funding: $100,000
Description: These one-year grants aim to support paradigm-shifting research that has the potential for momentous impacts on heart
disease and stroke. Only the top two rated applicants from each of the Scientific Review Subcommittees are invited to apply each year.
Principal
Investigator(s)
Institute
Project
Co-Investigator(s) Term
08/09 $
HSF
Total 08/09 $ Total $*
(All Partners) HSF
Total $*
(All Partners)
Theme
Sykes, Brian D.
University
of Alberta
Magic angle spinning NMR
studies of regulation in
cardiac muscle.
N/A
20092010
8,333
8,333
50,000
50,000
I
Weitz, Jeffrey I.
McMaster
University
Role of histidine-rich
glycoprotein in the regulation
of the intrinsic pathway of
coagulation.
N/A
20092010
8,333
8,333
50,000
50,000
I
Vascular Cognitive Impairment 2009
Partners: CSN, HSF.
Description: Projects supported through this initiative are multi-disciplinary, have the potential to impact changes in clinical practice and
significantly advance knowledge in the area of vascular cognitive impairment as it relates to small vessel disease and covert strokes. HSF
funds one of the four team grants.
Vascular Cognitive Impairment 2009
Principal
Investigator(s)
Institute
Project
Co-Investigator(s)
Term
08/09 $
HSF
Liu-Ambrose,
Teresa; Boyd,
Lara A.; Hsiung,
Ging-Yuek R.
University
of British
Columbia
Role of exercise in cognition
and function in seniors with
vascular cognitive impairment.
British Columbia:
Brasher, Penelope
M. A.; Feldman,
Howard H.;
Jacova, Claudia;
Lee, Philip.
20092011
126,804
Themes I: Basic Biomedical
II: Clinical
III: Health Services/Systems
Total 08/09 $ Total $*
(All Partners) HSF
126,804
499,996
Total $*
(All Partners)
499,996
Theme
I,II
IV: Population Health
25
Applied Public Health Chair 2008
Partners: IPPH, PHAC, CRPO, HSF.
Description: The Applied Public Health Chair platform supports population health interventions that address major risk factors for
chronic diseases such as heart disease, stroke, diabetes, obesity, and their underlying determinants. Focusing on community/societallevel factors (individual, social, cultural, economic, environmental) and their interactions, the program aims to prevent diasease and
promote and improve the health of society as a whole. The specific objectives are to fund high quality policy and program interventions;
to foster formal linkages with the public health system; and to support mentorship, education, and knowledge translation activities. HSF
is co-funding one Applied Public Health Chair in the area of obesity.
Applied Public Health Chair 2008
Principal
Institute
Investigator(s)
Raine, Kim D.
Project
University Environmental and populationof Alberta based strategies for chronic
disease prevention and the
promotion of healthy weights.
N/A
20082013
08/09 $
HSF
0
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
185,000 462,500
925,000
Theme
IV
Childhood Obesity Prevention and Treatment Operating Grants 2008
Partners: INMD, IHDCYH, CIHR/Rx&D, HSF.
Description: The primary objective of this funding opportunity is to strengthen research and translate knowledge into effective
interventions to prevent and treat childhood obesity. HSF is co-funding two of the five team grants.
Childhood Obesity Prevention and Treatment Operating Grants 2008
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Muhajarine,
Nazeem;
Neudorf,
Cordell O.
University of
Working upstream:
Saskatchewan effecting healthy
children through
neighbourhood
design.
Saskatchewan: BaxterJones, Adam Dominic;
Bell, Scott; Chad, Karen E.;
Green, Kathryn; Holden,
William J.; Sherar, Lauren.
Nova Scotia: Kirk, Sara.
20082011
17,003
von
Tigerstrom,
Barbara
Joanne
University of
Awareness, use
Saskatchewan and impact of
the children's tax
credit.
Saskatchewan: Chad, Karen
E.; Larre, Tamara; Reeder,
Bruce. Ontario: Cameron,
Christine; Mawani, Amin;
Tremblay, Mark S.
20082011
0
26
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
75,667 145,753
424,624
III,IV
48,364
241,884
IV
49,357
Intervention Research (Healthy Living and Chronic Disease Prevention) 2008
Partners: INMD, IPPH, IHDCYH, CPHI, HSF.
Description: This competition supports prompt initiations of intervention and evaluation research on programs, events, and/or policy initiatives/changes that will impact healthy living and/or chronic disease prevention at the population level. The initiative had five “rolling”
application deadlines throughout the year to facilitate and encourage these rapidly unfolding “natural experiments”. HSF is supporting
one of the five funded projects from the June 2008 competition.
Intervention Research (Healthy Living and Chronic Disease Prevention) 2008
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
Veugelers,
Paul J.
Economic
evaluation of a
school-based
program for the
prevention of
childhood obesity.
Alberta: Jamieson,
Stewart; Johnson, Jeffrey
A.; Ohinmaa, Arto E.
20082011
University of
Alberta
08/09 $
HSF
Total 08/09 $
(All Partners)
0
Total $* Total $*
HSF
(All Partners)
49,492 100,000
280,709
Theme
IV
Focus on Stroke 7 2008
Partners: HSF (lead), ICRH, IA, CSN.
Description: HSF leads the Focus on Stroke training initiative to support Doctoral Research Awards and Research Fellowships in the area
of stroke. The primary objectives are to increase stroke research capacity in Canada and to address the shortage of highly qualified personnel working in this important area.
Focus on Stroke 7 2008 Research Fellowships
Awardee
Institute
Project
Supervisor(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Acerra, Nicole University
of British
Columbia
Promoting stroke recovery
via somatosensory cortex
stimulation.
Boyd, Lara A.
Boe, Shaun
University of
Waterloo
Plasticity and functional
recovery in stroke
following use-dependent
rehabilitation and adjunct
therapy.
McIlroy, William E.
Brugniaux,
Julien V.
University of
Calgary
Chen,
Xuanmao
University of
Toronto
20082010
34,615
38,333
93,995
110,000
I,II
20082010
34,615
38,333
76,905
90,000
I,II
Role of erythropoietin in
Poulin, Marc J.
cerebrovascular regulation
and ventilatory control in
obstructive sleep apnea.
2008
22,575
25,000
22,575
25,000 I,II,III,IV
PDGF receptors
key regulators of
neuroprotection during
ischemia in the CNS.
20082010
40,635
45,000
76,905
90,000
MacDonald, John F.;
Orser, Beverly A.
Total $* Total $*
HSF
(All Partners)
Theme
I
>>
II: Clinical
27
Awardee
Institute
Project
Supervisor(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Choi, Hyun
Beom
University
of British
Columbia
A novel pathway in
astrocytes providing
a neuronal energy
substrate during ischemic
conditions.
MacVicar, Brian A.
Cook,
Douglas J.
Toronto
Western
Hospital
Establishing a preclinical
model of stroke in nonhuman primates.
LeblondLecrux,
Clotilde
Montreal
Neurological
Institute
Li, Hongbin
20082010
40,635
45,000
76,905
90,000
I
Tymianski, Michael
20082011
49,665
55,000
93,995
165,000
I,II
Etude des sous-types
d'interneurones impliqués
dans le couplage
neurovasculaire dans le
cortex cérébral.
Hamel, Edith
20082010
40,635
45,000
76,905
90,000
I
University of
Toronto
Mechanisms of cell
damage following stroke
that lead to alzheimer's
and dementia.
MacDonald, John F.;
Orser, Beverly A.
20082010
15,000
45,000
30,000
90,000
I
Mansfield,
Avril
Sunnybrook
Health
Sciences
Centre
Intervention to improve
reactive balance control
following a stroke.
McIlroy, William E.
20082010
15,000
45,000
30,000
90,000
II
McBane,
Joanne E.
University of
Toronto
Cardiovascular tissue
engineering with crosslinked vinyl-lysine
polyurethanes inducing
a wound healing
macrophage.
Santerre, J. Paul
20082010
40,635
45,000
76,621
90,000
I
Pialoux,
Vincent
University of
Calgary
Impact of physical activity
on cerebrovascular
regulation in women: role
of oxidative stress.
Poulin, Marc J.
20082010
5,000
45,000
10,000
90,000
I,II,IV
Rivera, José
C.
Université de
Montréal
Mechanisms of brain
neovascularization in the
newborn: major role for
GPR91.
Chemtob, Sylvain
20082010
40,635
45,000
76,621
90,000
I
Striemer,
Christopher L.
University
of Western
Ontario
Understanding the
cognitive and neural
correlates of optic ataxia.
Goodale, Melvyn A.
20082010
40,635
45,000
76,905
90,000
I
28
Total $* Total $*
HSF
(All Partners)
Theme
Focus on Stroke 7 2008 Doctoral Research Awards
Awardee
Institute
Project
Supervisor
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Fingas,
Matthew S.
University
of British
Columbia
Determining the timing
and mechanism of stroke
rehabilitation at the level of
individual synapses in vivo.
Murphy, Timothy
H.
Tang, Ada
University of
Toronto
Feasibility and effects of
cardiac rehabilitation after
stroke.
Brooks, Dina
Total $* Total $*
HSF
(All Partners)
Theme
20082011
16,706
18,500
37,598
66,000
I
20082009
19,866
22,000
37,598
44,000
II
DEVELOPMENTAL INITIATIVE
Secondary Stroke Prevention Health Services and Care Development Grants 2008
Description: These grants were provided to facilitate full applications to the Secondary Stroke Prevention Health Services and Care
initiative, including the development of a Knowledge Transfer and Exchange plan and a project team with the appropriate mix of
researchers and decision makers.
Secondary Stroke Prevention Health Services and Care Development Grants 2008
Province of Principal Investigator(s)
Term
Alberta
2008
5,000
5,000
5,000
5,000
II,III
Nova Scotia
2008
4,999
4,999
4,999
4,999
II,III
British Columbia
2008
5,000
5,000
5,000
5,000
II,III
Nova Scotia
2008
4,000
4,000
4,000
4,000
II,III,IV
II: Clinical
08/09 $ HSF
Total 08/09 $ (All Partners)
Total $* HSF
Total $* (All Partners)
Theme
29
CONTINUING INITIATIVES
Research Programs
Description: These one-year grants aim to support paradigm-shifting research that has the potential for momentous impacts on heart
disease and stroke. Only the top two rated applicants from each of the Scientific Review Subcommittees are invited to apply each year.
Principal
Institute
Investigator(s)
Project
Adeli,
Khosrow
Hospital for
Sick Children
Anti-diabetic and anti-atherogenic effects of inhibiting
intestinal fructose absorption.
N/A
Lerouge,
Sophie
Université de
Montréal
An injectable chitosan gel to
decrease complications after
endovascular aneurysm repair.
Paravicini,
Tamara
Ottawa
Hospital
Research
Institute
A potential role for salt-inducible kinase in the molecular
etiology of salt-sensitive
hypertension and hypertrophy.
30
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
20082009
24,300
24,300
48,600
48,600
I
Québec: Soulez,
Gilles.
20082009
25,000
25,000
50,000
50,000
I
Ontario: Touyz,
Rhian M.
20082009
14,625
14,625
29,250
29,250
I
Built Environment, Obesity and Health 2007
Partners: HSF (lead), IA, ICRH, IHDCYH, IMHA, INMD, IPPH.
Description: This unique initiative encourages collaborative, “horizontal” teams of researchers, urban planners, government and
non-governmental organizations to conduct policy-relevant research to explore how the built environment influences our health
and well-being. Built Environment, Obesity and Health 2007
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Barnett,
Tracie A.
Ste-Justine
Hospital
Features of the
built environment
in residential
neighbourhoods
that Influence excess
weight and weight
related behaviours in
a cohort of children at
risk for obesity.
Québec: Gauvin, Lise;
Lambert, Marie; Daniel,
Mark; Kestens, Yan;
Apparicio, Philippe;
McGrath, Jennifer J.;
Mongeau, Lyne; Brice,
Stéphane; Koushik, Anita;
Valois, Pascale.
20072010
105,760
Berry, Tanya
R.
University
of Alberta
A longitudinal
examination of the
relationship between
the built environment,
physical activity, and
social factors within
the Capital Health
Region of Alberta.
Alberta: Spence, John C.;
Nykiforuk, Candace; Predy,
Gerald; Edwards, Joy.
Nova Scotia: Blanchard,
Christopher.
20072010
Brauer,
Michael
University
of British
Columbia
Understanding the
impact of the built
environment on
decisions to cycle
as a mode of urban
transport.
British Columbia: Teschke,
Kay; Keller, Peter; Setton,
Eleanor; Shoveller,
Jean; Winters, Meghan;
Davidson, Gavin; Ho,
Cheeying; Becker, Jack;
Hancock, Trevor.
Faulkner, Guy
E. J.; Buliung,
Ron.
University
of Toronto
Built Environment
and Active Transport
(BEAT).
Frank,
Lawrence
University
of British
Columbia
Built environment
influences on diet,
physical activity,
and obesity: a
transdisciplinary
approach.
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
150,014 178,779
338,986
II,III,IV
20,173
137,887
42,944
353,418
IV
20072009
13,614
68,072
18,622
144,135
IV
Ontario: Salmon, Art;
Kennedy, Jacky; Howard,
Donna; Fusco, Caroline;
Adlaf, Edward M.
20072010
22,130
175,166
38,422
401,435
IV
Alberta: Raine, Kim D.
Ontario: Cameron,
Roy; Fisher, Patrick D.;
Thompson, Mary E.
20072010
200,000
200,000 364,427
600,000
IV
>>
II: Clinical
31
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
Lyons, Renée
F.; Grant,
Jill L.
Dalhousie
University
Optimizing investments in the built
environment to
reduce youth obesity.
Nova Scotia: Blanchard,
Chris; Shields, Christopher
A.; Rehman, Laurene A.;
Parker, Louise; Manuel,
Patricia M.; Kirk, Sara F. L.;
Dummer, Trevor J. B.; Pitter,
Robert; Arthur, Michael
H.; Chircop, Andrea M.
Ontario: Rainham, Daniel
G. C.
20072010
82,912
199,160 201,526
597,437
III,IV
Nykiforuk,
Candace
University
of Alberta
Obesity prevention
and the built environment: examining opportunities
and barriers in four
Alberta: Vallianatos, Helen;
Schopflocher, David; Raine,
Kim D.
20072010
112,017
186,694 206,833
567,397
III,IV
Spence, John
C.
University
of Alberta
A longitudinal study
of environmental
determinants of
overweight among
children: the SHAPEs
of things to come.
Alberta: Veugelers, Paul
J.; Ball, Geoof D. C.; Predy,
Gerald N. British Columbia:
Frank, Lawrence D.
Ontario: Boule, Normand.
20072010
59,337
141,955 161,962
475,107
IV
Teschke, Kay
E.
University
of British
Columbia
Bicyclists' Injuries
and the Cycling
Environment (the
BICE study).
British Columbia: Babul,
Shelina; Becker, Jack;
Brubacher, Jeff; Cripton,
Peter; Fenton, Bonnie;
Harris, Anne; Hay, David;
Hunte, Garth; Reynolds,
Conor; Stary, Peter
Ontario: Tomlinson, David;
Wentworth, Barbara;
Friedman, Steven;
Cusimano, Michael;
Chipman, Mary.
20072010
101,649
191,791 250,784
579,379
IV
Alberta communities.
32
Monitoring and Optimizing CPR 2007
Description: The goal of this funding opportunity is to advance knowledge to improve CPR outcomes in adult and paediatric populations. The results should also contribute to the 2010 Guidelines for Resuscitation.
Monitoring and Optimizing CPR 2007
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Nanthakumar, Toronto
Kumaraswamy General
Hospital
The real-time monitoring
of ventricular fibrillation
dynamics from human
Langendorff model for
optimizing resuscitation
outcomes.
Ontario: Dorian, Paul;
Krishnan, Sridhar.
20072010
200,000
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
200,000 589,674
589,674
Theme
I,II,III
Resuscitation and Knowledge Transfer 2007
Partners: HSF (lead), ICRH.
Description: This strategic initiative encourages research that explores how current and proposed policies, strategies, tools, training
approaches, legislation or guidelines in resuscitation influence the uptake of knowledge by health professionals including lay-rescuers
and first responders.
Resuscitation and Knowledge Transfer 2007
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
Morrison,
Laurie J.;
Dorian,
Paul; Scales,
Damon C.
Sunnybrook
Health
Sciences
Centre
Strategies for post
arrest care - the
"SPARC" network
project.
Ontario: Ferguson, Niall D.;
Dainty, Katie N.; Laupacis,
Andreas ; Slutsky, Arthur
S.; Wax, Randy Stuart;
Zwarenstein, Merrick F.;
Rubenfeld, Gordon D.;
Thorpe, Kevin E.; Brooks,
Steven C.; Dorian, Paul;
Scales, Damon C. USA:
Needham, Dale M.
20072010
98,167
98,167 171,000
Vaillancourt,
Christian
Ottawa
Hospital
Research
Institute
A survey of
attitudes and
factors associated
with successful
CPR knowledge
transfer in an older
population most
likely to witness
cardiac arrest.
Ontario: Stiell, Ian G.;
Grimshaw, Jeremy M.;
Brehaut, Jamie C.; Osmond,
Martin H.; Wells, George A.
20072010
44,734
44,734
II: Clinical
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
73,269
Theme
196,000
II,III
98,269
II,III,IV
33
Cardiovascular Complications of Diabetes 2007
Partners: ICRH, CDA, IAPH, III, INMD, Pfizer, Tekes, HC, HSF.
Description: This program focuses on the production of new knowledge and the translation of research findings, at the interface
between the diabetes and the cardiovascular research communities, into improvements in the health care systems and the health
of the populations.
High Risk Seed Grants
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Moody, Alan
Sunnybrook
Health
Sciences
Centre
In vivo detection of
early diabetic vessel
wall disease - a possible
role for the RAGE-AGERBC-Endothelial (RARE)
complex at the microand macrovascular
levels.
Ontario: Burns, Peter
N.; Silverberg, Jay;
Tobe, Sheldon W.
Moreau,
Pierre;
Mathieu,
Patrick.
Université de
Montréal
Total $* Total $*
HSF
(All Partners)
Theme
20072010
0
44,492
75,000
273,246
II
Protein gamma
Québec: Poirier, Paul;
carboxylation in diabetes: Pibarot, Philippe;
protential therapeutic
Voisine, Pierre.
avenue for cardiovascular
calcification.
20072009
0
58,333
75,000
300,000
I
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Petrella,
Robert J.
Innovation to reduce
cardiovascular
complications of
diabetes at the
intersection of discovery,
prevention and
knowledge exchange.
Ontario: Holdsworth,
David W.; Shoemaker,
J. Kevin ; Stewart,
Moira; Harris, Stewart
B. Finland: Tikkanen,
Heikki.
20072012
100,000
Team Grant
London
Health
Sciences
Centre
34
Total $* Total $*
HSF
(All Partners)
577,418 500,000
2,799,530
Theme
I
Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Team
Grants 2006
Partners: IGH, IPPH, IA, IAPH, ICR, ICRH, IHSPR, IHDCYH, III, INMHA, INMD, CIHR - Ethics, CIHR - KT, CIHR - HIV/AIDS, CIHR - GHRI, HSF.
Description: Interdisciplinary Capacity Enhancement (ICE) grants provide support for new or existing multi-disciplinary research teams.
These grants enabled teams to build capacity, add expertise to their core competencies, and develop strategies for knowledge transfer
and exchange. This targeted investment is expected to lead to understanding health disparities and addressing these disparities to
improve the health status of vulnerable populations.
Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Team
Grants 2006
Principal
Investigator(s)
Institute
Project
Co-Investigator(s)
Term
Grace, Sherry
L.; Stewart,
Donna E.
University
Health
Network
Cardiovascular
secondary prevention
for vulnerable
populations: an
interdisciplinary
approach to improving
access to services and
outcomes.
Ontario: Alter, David
A.; Anand, Sonia S.;
Bunker, Steve; Harvey,
Paula J.; Holder, Glenn;
Kaur, Rimmy; Oh, Paul;
Rukholm, Ellen E.; Rush,
James Walter E.; Scholey,
Patricia E.; Williamson,
Karen M.
20062011
08/09 $
HSF
Total 08/09 $
(All Partners)
50,000
Total $* Total $*
HSF
(All Partners)
131,705 249,755
704,792
Theme
III
Genomic Medicine and Human Development 2005
Partners: ICRH, IG, IHDCYH, HSF.
Description: These operating grants support projects that bridge clinical investigation and basic scientific research to strengthen the
study of human development. HSF co-funded one project listed below.
Genomic Medicine and Human Development 2005
Principal
Investigator(s)
Institute
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $*
HSF
Total $*
(All Partners)
Andelfinger,
Gregor U.;
Nemer, Mona;
Richter, Andrea
M.; Rozen, Rima.
Ste-Justine
Hospital
Genetic determinants
of congenital heart
disease.
Québec: Bigras, JeanLuc; Dubé, Marie-Pierre;
Khairy, Paul.
20052010
120,000
489,050
600,000
2,382,246
II: Clinical
Theme
I,II,IV
35
Canadian Tobacco Control Research Initiative 2004
Partners: CTCRI, INMHA, ICR, IAPH, ICRH, IGH, IHDCYH, NCIC, CCS, HC, CLA, APQ, HSF.
Description: This program focuses on developing research capacity in the area of tobacco control and nicotine addiction, addressing
gaps in research data, stimulating knowledge translation, and fostering national coordination as well as building international
collaboration. It is expected that outcomes of the research will inform intervention strategies. Interdisciplinary Capacity Enhancement (ICE) Grant Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
O'Loughlin,
Jennifer
Strengthening
the links between
research, practice,
and public policy to
reduce the burden of
tobacco.
Ontario: Tyndale, Rachel.
Québec: Gauvin, Lise;
Paradis, Gilles; Renaud,
Lise; Tremblay, Michele.
U.S.A: DiFranza, Joseph.
20042011
135,000
McGill
University
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
300,000 675,000
1,500,000
Theme
III
Inflammation and Thrombosis 2004
Partners: NHLBI, ICRH, HSF.
Description: HSF partners with CIHR and the US National Institutes of Health on this initiative to fund research on the interplay between
inflammation and thrombosis. Specifically, funding was provided to support translational and pre-clinical studies for the development of
anti-coagulation agents for better management of thrombotic disorders. Inflammation and Thrombosis 2004
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
Bajzar, Laszlo
Carboxypeptidases
in thrombosis and
inflammation.
N/A
20032008
University
of Alberta
36
08/09 $
HSF
32,500
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
108,447 260,000
761,596
Theme
I
Molecular and Cellular Imaging 2004
Partners: NHLBI, ICRH, HSF.
Description: Multi-disciplinary approaches are needed to address technical challenges associated with imaging cellular systems. The
objectives of this initiative are to explore novel non-invasive probes; and using these probes, develop novel or adapt current technologies to image the heart, lung, and blood systems at the cellular and molecular level in vivo.
Molecular and Cellular Imaging 2004
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
Theme
HSF
(All Partners)
Cloutier, Guy
HôtelDieu de
Montréal
Cellular imaging
of blood flow
rheological
disorders.
Québec: Trudel, Marie.
U.S.A: Armstrong, Jonathan
K.; Fisher, Timothy C.;
Meiselman, Herbert J.
20032008
16,250
112,694 130,000
1,081,860
I
Rutt, Brian
K (Canadian
Lead);
Weissleder,
Ralph
(American
Lead)
Robarts
Research
Institute;
Harvard
Medical
School
MR imaging of
myeloperoxidase
activity.
Ontario: Bowen, Chris;
Hegele, Robert A.; Huff,
Murray W.; Pickering, J.
Geoffrey; Rogers, Kem A.
U.S.A: Bogdanov, Alexei
A.; Jaffer, Farouc Amin;
Josephson, Lee; Libby, Peter;
Perez, J. Manuel.
20032008
16,250
110,796 130,000
1,063,640
I
Obesity New Emerging Teams (NETs) 2004
Partners: INMD, HSF.
Description: This program promotes the formation of new research teams or the growth of small existing teams of researchers in the
area of obesity/healthy body weight. Obesity New Emerging Teams (NETs) 2004
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
Elliott, Susan
J.
McMaster
University
Understanding the
individual and socioenvironmental health
risks of obesity: the
Canadian Heart
Health Surveys
follow-up study.
Alberta: Raine, Kim D. Nova
Scotia: Joffres, Michel R.;
Kirkland, Susan; MacLean,
David R. Saskatchewan:
Pahwa, Punam; Reeder,
Bruce. U.S.A.: Katzmarzyk,
Peter T.
20042010
75,000
275,000 500,000
1,500,000
IV
Lambert,
Marie
Ste-Justine
Hospital
Familial study on
the prevention
of cardiovascular
disease and type 2
diabetes in children
and adolescents.
Québec: O'Loughlin,
Jennifer Lee; Tremblay,
Angelo ; Gray-Donald,
Katherine; Hanley, James
A; Levy, Emile E.H.; Paradis,
Gilles; Poirier, Paul.
20042010
75,000
274,944 500,000
1,499,776
II
II: Clinical
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
37
Palliative / End of Life Care 2004
Partners: ACB, BCCA, CCMB, IA, ICR, ICRH, IGH, IHSPR, IHDCYH, INMHA, CIHR-KT, HSF.
Description: This competition was launched in 2004 to support palliative/end-of-life care research. As a partner on the initiative, HSF
primarly focused on the communication between family and health care providers at end of life and is co-funding one project within this
priority area.
Palliative / End of Life Care 2004
Principal
Investigator
Institute
Project
Co-Investigator(s)
Term
08/09 $
HSF
Heyland,
Daren K.
Queen's
University
Understanding
and improving
communication and
decision-making at
the end of life.
British Columbia: Kuhl,
David R. Ontario: Cook,
Deborah J.; Gafni, Amiram;
Giacomini, Mita; Tranmer,
Joan E.
20042010
150,000
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
268,836 662,800
1,325,641
Theme
III
Regenerative Medicine 2004
Partners: CIHR, INMHA, IG, ICRH, IMHA, SCN, HSF.
Description: Innovative projects in the areas of Stem Cells, Tissue Engineering, and Nanotechnology Development and Nanomedicne
are supported through this initiative. HSF provided funding to one of eight New Emerging Teams (NETs).
Regenerative Medicine 2004
Principal
Investigator(s)
Institute
Project
Co-Investigator(s)
Term
08/09 $
HSF
Galipeau,
Jacques
Jewish
General
Hospital
Cardiovascular and
respiratory stem cell
plasticity - CARE
project.
British Columbia:
Lansdorp, Peter Michael;
Karsan, Aly. Ontario: Liu,
Peter P.; Stewart, Duncan
John.
20052010
100,000
38
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
300,000 500,000
1,500,000
Theme
I
Resuscitation Outcomes Consortium (ROC) 2004
Partners: ICRH, DRDC, NHLBI, HSF.
Description: The Resuscitation Outcomes Consortium (ROC) is a multi-centre clinical trial network to conduct research in the areas of
cardiopulmonary arrest and traumatic injury leading to arrest. The ROC, consisting of ten Regional Clinical Centers (RCCs) in the US and
Canada and a Data and Coordinating Centre (DCC), provides the necessary infrastructure to conduct multiple collaborative trials to aid
rapid translation of promising scientific and clinical advances to improve resuscitation outcomes.
Resuscitation Outcomes Consortium (ROC) 2004
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
Theme
HSF
(All Partners)
Slutsky,
Arthur S.
St.
Michael's
Hospital
Toronto regional
resuscitation
research out of
hospital network.
Ontario: Black, Sandra E.; Davis,
David; Dorian, Paul; Hutchison,
James S.; Lavery, James;
Morrison, Laurie J.; Redelmeier,
Donald A.; Rotstein, Ori D.;
Sibbald, William.
20042009
65,000
390,870 325,000
2,167,032
III
Stiell, Ian
Ottawa
Hospital
Research
Institute
Proposal
to create a
Canadian
collaborative
RCC.
British Columbia: Abu-Laban,
Riyad B.; Christenson, James
M.; Levy, Adrian R.; Macnab,
Andrew J.; Russell, James
A.; Simons, Richard K.; Sun,
Charles Y. Ontario: Herbert,
Paul C.; Osmond, Martin H.;
Vaillancourt, Christian; Wells,
George A.
20042009
65,000
350,121 325,000
1,960,680
III
Gender and Sex Determinants of Circulatory and Respiratory Health - Interdisciplinary Capacity Enhancement (ICE) Team Grants 2004
Partners: IGH, ICRH, CLA, HSF.
Description: This program helps forge multi-disciplinary teams and supports research on gender determinants of lung disease,
atherosclerotic risks, and acute coronary syndromes. The Interdisciplinary Capacity Enhancement (ICE) Grants attract researchers from
relevant disciplines including those who have not been primarily or previously involved in health research. Four teams were funded
through this initiative, with two receiving funding from HSF.
Gender and Sex Determinants of Circulatory and Respiratory Health - Interdisciplinary Capacity Enhancement (ICE) Team Grants 2004
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Anand, Sonia
Sex and gender
determinants of acute
coronary syndromes
and the metabolic
syndrome: Interdisciplinary Capacity
Enhancement (ICE)
teams grant program.
Ontario: Alter, David A.;
Arthur, Heather M.; Gerstein,
Hertzel C.; Lonn, Eva M.;
Mehta, Shamir; Natarajan,
Madhu K.; Sharma, Arya
M.; Yusuf, Salim. Germany:
Blankenberg, Stefan.
20052010
107,500
McMaster
University
Total 08/09 $
(All Partners)
Total $* Total $*
Theme
HSF
(All Partners)
288,126 537,500
1,476,251
IV
>>
II: Clinical
39
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Pilote, Louise
Gender and sex
determinants of
cardiovascular disease: from bench to
beyond.
Alberta: Ghali, William;
Norris, Colleen M. British
Columbia: Humphries,
Karin H. Nova Scotia: Cox,
Jafna L.; Kirkland, Susan.
Ontario: Tu, Jack V. Québec:
Eisenberg, Mark J.; Hamet,
Pavel; O'Loughlin, Jennifer
Lee; Tremblay, Johanne.
20052010
107,500
McGill
University
Total 08/09 $
(All Partners)
Total $* Total $*
Theme
HSF
(All Partners)
288,126 537,500
1,476,247
IV
Training Programs
Partners: HSF (lead), AstraZeneca, CSN, CIHR/Rx&D.
Description: This initiative, led by HSF, supports Doctoral Research Awards and Research Fellowships in the area of stroke. These funds
help build greater capacity for stroke research in Canada. The initiative has been launched by HSF annually since 2002.
Awardee
Institute
Project
Supervisor
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Billinghurst,
Lori L.
Hospital for
Sick Children
Common childhood illnesses and
cerebral sinovenous thrombosis:
a national population-based
surveillance study.
deVeber,
Gabrielle A.
20072009
Dilworth,
David John
Russell
University of
Determining the mechanism(s) of
California San Col4a1- mediated cerebrovascular
Francisco
disease.
Gould,
Douglas B.
20072008
Green,
Theresa L.
University of
Calgary
Aggressive surgical interventions
and stroke: impact on quality of life
and caregiver outcomes.
Demchuk,
Andrew M.
20072009
Hamova,
Daniela
McGill
University
Sequence and structural features of
alternative splicing in ischemic injury.
Majewski,
Jacek A.
Higgins,
Johanne
Royal Victoria
Hospital
Enhancing upper extremity function
post-stroke: the combined effects of
brain stimulation and rehabilitation.
Jin, Albert
Y.
University of
Calgary
Kelly,
Melissa
University of
Ottawa
Total $* Total $*
HSF
(All Partners)
Theme
2,681
55,000
27,145
110,000
II,IV
13,333
45,000
58,333
I,II,IV
2,193
45,000
17,211
90,000
II,IV
20072009
2,193
45,000
17,211
90,000
I
Koski, Lisa
20072009
2,193
45,000
17,211
90,000
II
Magnetic resonance molecular
imaging of the early endothelial
inflammatory response in focal
ischemia.
Barber, Philip
A
20072008
280
5,750
24,744
60,750
I,II
Mitochondrial dynamics in the
regulation of neuronal survival.
Slack, Ruth
S.
20072009
2,193
45,000
17,211
90,000
I
>>
40
Awardee
Institute
Project
Supervisor
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Lai, GueyJen
University of
Lethbridge
Memory loss and recovery after ischemia damage and regeneration of
hippocampal neurons.
Sutherland,
Robert J.
Rand,
Debbie
University
of British
Columbia
Quantification of upper- extremity movement in post- stroke participants: transition from hospital to
community.
Tang, Kim
San
University of
Manitoba
Teichert,
AnoukMartine
University of
Toronto
20072009
2,193
45,000
20,897
110,000
I
Eng, Janice
J.
20072009
2,193
45,000
17,211
90,000
II,III
The role of astrocytic and neuronal
PARP1 in stroke.
Anderson,
Christopher
M.
20072009
2,193
45,000
17,211
90,000
I
Gene trap analysis of neural and
endothelial cell interactions.
van der
Kooy, Derek
J.
20072009
2,193
45,000
20,897
110,000
I
Turner, Gary University of
R.
California,
Berkeley
Optimizing neurorehabilitation using D'Esposito,
biomarkers of neuropsychological
Mark
and functional change after cognitive retraining.
20072010
45,000
45,000
90,000
I,II
Xue,
Mengzhou
Neurotoxicity of proteolytic enzymes
following intracerebral hemorrhage.
Yong, V. Wee
20072009
1,949
45,000
17,211
90,000
I
08/09 $
HSF
Total 08/09 $
(All Partners)
University of
Calgary
Total $* Total $*
HSF
(All Partners)
Theme
Awardee
Institute
Project
Supervisor
Term
Bérard,
Jessica
Renée
McGill
University
The role of optic flow during locomotion in healthy and hemiparetic
individuals.
Lamontagne,
Anouk
20072010
1,072
22,000
16,286
66,001
I,II
Hewlett,
Krista A.
Memorial
Effect of immune modulation on
University of
functional recovery following stroke
Newfoundland in rats.
Corbett,
Dale R.
20072010
1,072
22,000
16,286
66,001
I
Klimstra,
Marc
University of
Victoria
20072010
1,072
22,000
16,286
66,001
I,II
Neuromechanical basis for using arm Zehr, E. Paul
movement to facilitate leg muscle
activity during walking.
II: Clinical
Total $* Total $*
HSF
(All Partners)
Theme
41
Awardee
Institute
Project
Supervisor
Term
Ander,
Bradley P.
University of
California,
Sacramento
Protection against delayed damage
of intracerebral hemorrhage through
inhibition of src kinase.
Sharp,
Frank R.
Gorbet,
Diana J.
University of
Waterloo
Sex-related differences in human
visuomotor control: implications for
stroke recovery.
Honoré,
Ste-Justine
Jean-Claude Hospital
MacIntosh,
Bradley J.
John
Radcliffe
Hospital
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
20062008
6,533
11,667
50,400
90,000
I
Staines, W.
Richard
20062008
7,143
30,000
26,190
110,000
I,II
Pro-survival role of the peroxidation
products isofurans on cerebral
microvascular endothelial cells.
Chemtob,
Sylvain
20062008
4,762
20,000
21,429
90,000
I
Investigating neurovascular coupling
in the stroke brain using functional
imaging techniques.
Matthews,
Paul M.
20062008
11,200
20,000
50,400
90,000
I,II,III
08/09 $
HSF
Total 08/09 $
(All Partners)
Awardee
Institute
Project
Supervisor
Term
Auriat,
Angela M.
University of
Alberta
Mechanisms of rehabilitation therapy
following stroke.
Colbourne,
Frederick
20062009
5,000
21,000
15,714
66,000
I
FreitasAndrade,
Moises
National
Research
Council of
Canada
(Ottawa)
Role of placental growth factor in
hypoxia-induced brain angiogenesis.
Stanimivoric,
Danica
20062009
5,238
22,000
15,714
66,000
I
Ge, Yuan
University
of British
Columbia
Modulation of AMPA receptor
trafficking in the animal model of
stroke.
Wang, Yu
Tian
20062008
8,524
22,000
24,500
66,000
I,II
Silasi,
Gergely
University of
Alberta
Improving stroke outcome through
growth-factor induced recruitment of
endogenous stem cells.
Colbourne,
Frederick
20062009
5,238
22,000
15,714
66,000
I
42
Total $* Total $*
HSF
(All Partners)
Theme
Awardee
Institute
Project
Supervisor
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Aleyasin,
Hossein
University of
Ottawa
The role of DJ-1, in stroke model
of neuronal death.
Park, David S.
Langdon,
Kris D.
Memorial
Effect of cognitive and physical
University of
activity on the progression of
Newfoundland vascular dementia.
Corbett, Dale
R.
Total $* Total $*
HSF
(All Partners)
Theme
20052008
2,775
10,500
17,441
66,000
I,II
20052008
2,775
10,500
17,441
66,000
I
Focus on Stroke 3 2004 New Investigators
Awardee
Institute
Project
Supervisor
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Kong, Jiming
University of
Manitoba
BNIP3-activated atypical apoptosis
pathway in ischemic neuronal cell
death.
N/A
Todd,
Kathryn G.
University of
Alberta
Investigations of novel strategies
to improve cellular and behavioral
outcomes after adult and perinatal
cerebral ischemia.
N/A
Total $* Total $*
HSF
(All Partners)
Theme
20042009
14,250
42,750
71,250
285,000
I
20042009
14,250
42,750
71,250
285,000
I
Target Obesity Personnel Awards 2004
Partners: HSF (lead), CDA, ICR, IGH, IHDCYH, IMHA, INMD.
Description: This initiative supports obesity research by newly established investigators, students, recent graduates, and postgraduates
including health professionals (such as physicians, nurses, dietitians, exercise physiologists, and behavioral scientists). Projects that were
approved for funding focus on the risks for chronic diseases and strategies to reduce these risks.
Target Obesity Personnel Awards 2004 New Investigators
Awardee
Institute
Project
Supervisor Term
Netticadan,
Thomas
St. Boniface
General Hospital
Research Centre
Mechanisms underlying cardiac
contractile dysfunction in type II
diabetes.
N/A
II: Clinical
20042009
08/09 $
HSF
Total 08/09 $
(All Partners)
55,000
Total $* Total $*
Theme
HSF
(All Partners)
55,000 256,124
275,000
I
43
Strategic Training Initiative in Health Research (STIHR) 2003
Partners: ICRH, HSF.
Description: The STIHR platform encourages trans-disciplinary integrative heath research through the training of the next generation of
investigators. The program aims to increase the capacity of Canada’s research enterprise to address important questions in all areas of
health research. HSF supports a total of 11 STIHR grants over two competitions (2003 and 2002).
Strategic Training Initiative in Health Research (STIHR) 2003
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
Arthur,
Heather M.
McMaster Training
University program
for the
development
of
cardiovascular
nursing
research
capacity in
Canada.
Alberta: King, Kathryn M.; Tapp,
Dianne M. British Columbia:
Young, Lynne E. Nova Scotia:
McFetridge, Judith Ann. Ontario:
Rukholm, Ellen; Tranmer, Joan E.;
Watt-Watson, Judith H. Québec:
Purden, Margaret Ann; RobichaudEkstrand, Sylvie.
20032009
18,750
293,750 203,143
1,800,000 I,II,III,IV
Fliegel, Larry
University Membrane
of Alberta proteins and
cardiovascular
disease.
Alberta: Casey, Joseph R.; Coe,
James Y.; Glover, J.N. Mark; James,
Michael N.G.; Kavanagh, Katherine
M.; Light, Peter E.; Michalak,
Marek; Robertson, Murray; Young,
Howard S.
20032009
18,750
272,250 213,143
1,671,000
I,II
MacGillivray,
Ross T.
University
of British
Columbia
British Columbia: Brooks, Donald E.;
Burtnick, Leslie D.; Carter, Cedric J.;
Devine, Dana V.; Haynes, Charles A.;
Karsan, Aly; Lehman, Darrin L.; Mauk,
Grant; Maurer-Spurej, Elizabeth;
McMaster, Robert; McNagny,
Kelly M.; Orvig, Chris; Overall,
Christopher; Podor, Thomas J.;
Pryzdial, Edward L.G.; Roberts, Clive
R.; Scott, Mark; Strynadka, Natalie
C. J.
20032010
18,750
293,750 193,143
1,800,000
II
Training
program in
transfusion
science.
>>
44
Principal
Institute
Investigator(s)
Project
Co-Investigator(s)
Term
Paré, Peter D.
University
of British
Columbia
IMPACT:
Integrated
and Mentored
Pulmonary And
Cardiovascular
Training.
British Columbia: Allard, Michael F.;
Ayas, Najib; Bai, Tony; Cunningham,
Kenneth F.; Dorscheid, Delbert R.;
Fleetham, John A.; Frohlich, Jiri
J.; Fitzgerald, J. Mark; Granville,
David J.; Hayashi, Shizu; Hegele,
Richard; Hill, John S.; Hogg,
James C.; Levy, Robert Daniel;
Mayo, John; McManus, Bruce M.;
Muller, Nestor; O, Karmin; Podor,
Thomas J.; Pritchard, Haydn;
Road, Jeremy D.; Russell, James
A.; Ryan, Frank; Sandford, Andrew
J.; Schellenberg, Robert; Seow,
Chun Y.; Van Breemen, Casey;
van Eeden, Stephan F.; Walley,
Keith R.; Wang, Xiaodong; Yang,
Decheng. Manitoba: Anderson,
Hope D. Intengan; Becker, Allan;
Choy, Patrick C.; Dhalla, Naranjan
S.; Dixon, Ian M.; Ducas, John;
Gounni, Abdelilah Soussi; Guzman,
Randolph P.; Halayko, Andrew;
Hatch, Grant M.; Kardami, Elissavet;
Lukas, Anton; Mink, Steven N.;
Netticadan, Thomas; Pierce, Grant
N.; Singal, Pawan K.; Stephens,
Newman L.; Tappia, Paramjit S.;
Wigle, Jeffrey T.; Yang, Xi; Zahradka,
Peter.
20032010
18,750
293,750 213,143
1,800,000
I,II,IV
Vance, Dennis
E.
University The SCOLAR
of Alberta (Stroke,
Cardiovascular,
Obesity, Lipid,
Atherosclerosis
Research) training program.
Alberta: Agellon, Luis B.; Francis,
Gordon A.; Lee, Mark W.; Lehner,
Richard; Majumdar, Sumit; Vance,
Jean.
20032009
18,750
293,750 213,143
1,800,000
I,II,IV
Wang, Rui
Lakehead
University
Alberta: Roth, Sheldon. Ontario:
Brien, James F.; Nakatsu, Kanji.
Québec: Blaise, Gilbert A.;
Troncy, Eric T. E. Saskatchewan:
Gopalakrishnan, Venkat; Hurst,
Thomas S.; Loewen, Michele;
McNeill, J Robert; Melo, Luis
Gabriel; Reeder, Bruce; Saucier,
Deborah; Thornhill, James A.; Van
uum, Stan H. M.; Wilson, Thomas W.;
Wu, Lingyun; Zhang, Wenjun.
20032009
18,750
293,750 213,143
1,800,000
I,II,IV
Gasotransmitter
REsearch
And Training
(GREAT).
II: Clinical
08/09 $
HSF
Total 08/09 $
(All Partners)
Total $* Total $*
HSF
(All Partners)
Theme
45
46
APPENDIX
B
NATIONAL PERSONNEL AWARDS
Photo: Dr. Shelagh Coutts (University of Calgary) is the 2009-2010 recipient of the Distinguished Clinician Scientist award, which is supported by the Heart
and Stroke Foundation, CIHR Institute of Circulatory and Respiratory Health, and AstraZeneca Canada Inc. The award is offered to the highest ranked
eligible clinician in the New Investigator competition.
Doctoral Research Awards
Awardee
Supervisor
Institute
Project
Keywords
Term
08-09 $
Total $*
Antunes, Tayze
Tatiana
Sorisky,
Alexander
University of
Ottawa
Thyroid stimulating hormone
as a regulator of atherogenic
adipokines.
Thyroid stimulating hormone,
adipose tissue, interleukin-6,
adipokines, cardiovascular
disease.
20062010
21,000
73,500
Theme
I,II
Arguin, Guillaume Guillemette,
Gaètan
Université de
Sherbrooke
Mecanisme de regulation
du recepteur de l' inositol
1,4,5- trisphosphate de type 2
(IP3R-2).
Second messagers, calcium,
signalisation intracellulaire,
phosphorylation, recepteur
de l' inositol 1, 4, 5trisphosphate (IP3Rs).
20072010
21,000
63,000
I
Artemenko, Yulia
Sorisky,
Alexander
Ottawa
Health
Research
Institute
Role of SHIP2 in adipose
tissue growth.
Obesity, adipogenesis,
PDGF, SHIP2, insulin.
20072009
3,500
21,000
I
Aubin, MarieClaude
Perrault,
Louis P.;
Calderone,
Angelino
Université de
Montréal
Obesity and intrinsic cardiac
remodeling following an
ischemic insult.
Diète riche en gras, infarctus
du myocarde, remodelage
ventriculaire, statines,
remodelage nerveux.
20072009
21,000
42,000
I
Bai, Ni (Nicola)
van Eeden,
Stephan
F.; van
Breemen,
Cornelis
St. Paul's
Hospital
Mechanisms underlying
particulate matter air
pollution-induced
atherosclerosis.
Particulate matter air
pollution, endothelial
function, atherosclerosis.
20072010
16,625
52,500
I
Bourgault, Steve
Fournier,
Alain;
Vaudry,
David D.V.
INRS
Développement
et caractérisation
pharmacologique d'agonistes
à haute stabilité métabolique
du neuropeptide PACAP.
Accidents vasculaires
cérébraux, apoptose,
neurone, neuropeptide,
neuroprotection.
20062009
21,000
63,000
I
Chan, Anita Y.M.
Dyck, Jason
R.B.
University of
Alberta
The effects of PRKAG2
mutations on cardiac energy
metabolism.
AMPK, PRKAG2,
hypertrophy, metabolism,
glycogen.
20062009
17,500
59,500
I
Chen, Wenqian
Chen, S. R.
Wayne
University of
Calgary
Ryanodine receptor regulation Cardiac arrhythmias and
by luminal Ca2+ and its role in sudden death, ryanodine
heart disease.
receptor, genetic mutations,
Ca2+ alternans, transgenic
animal model.
20082011
21,000
63,000
I
Clément, Martin
Escher,
Emmanuel
Université de
Sherbrooke
Détermination de la pochette
de liaison du récepteur
AT1 par MPA (methionine
proximity assay).
Recepteurs couples aux
proteines G, angiotensine II,
pochette de liaison, structure
mecanismes d'activation.
20062009
21,000
63,000
I
Dastani, Zari
Genest, Jr.,
Jacques;
Engert,
James C.
McGill
University
Genetics of high density
lipoprotein-cholesterol.
Genetics, gene
identification, cholesterol,
high density lipoprotein,
cardiovascular risk factor.
20062009
21,000
63,000
I,II,IV
* Amount shown represents stipend value (not including obligatory benefits and travel allowance). This amount may change depending on circumstances.
48
Awardee
Supervisor
Institute
Project
Keywords
Term
08-09 $
Total $*
David, Laurence
S.
Snutch,
Terrance P.
University
of British
Columbia
Cardiac 1H T-type calcium
channels and hypertension.
Hypertension, T-type clacium
channel, smooth muscle
contraction, ion channel
modulation, site-directed
mutagenesis.
20062010
21,000
63,000
I
Dent, Melissa R.
Dhalla,
Naranjan S.
University of
Manitoba
Gender differences in the
mechanisms involved in the
development of cardiac
remodelling.
Gender differences,
cardiac remodelling, signal
transduction mechanisms,
heart failure, cardiac
hypertrophy.
20062009
3,500
31,500
I
Duan, Qingling
Rouleau,
Guy A.
CHUM
Genetic investigation of
angioedema associated with
angiotensin I-converting
enzyme inhibitors.
Pharmacogenomics,
angiotensin I-converting
enzyme inhibitors,
quantitative trait,
susceptibility loci, kinin
metabolism.
20062009
3,500
42,000
I,II,IV
Dungey, Alison A.
Stewart,
Duncan J.
St. Michael's
Hospital
Kruppel-like factor 2: a
novel treatment strategy
for pulmonary arterial
hypertension?
Kruppel-like factor
2, pulmonary arterial
hypertension, endothelium,
gene therapy, human.
20062009
21,000
63,000
I,II
Dupasquier,
Chantal
Pierce,
Grant N.
University of
Manitoba
The effects of trans fatty
acid supplementation on
inflammation, obesity, and
atherosclerosis.
Trans fatty acids, flaxseed,
atherosclerosis, obesity,
inflammation.
20072009
3,500
21,000
I
Eguchi, Megumi
Sweeney,
Gary
York
University
Regulation of cardiomyocyte
apoptosis by adiponectin.
Heart failure, apoptosis,
obesity, adiponectin.
20082011
21,000
63,000
I
Foster, Glen E.
Poulin, Marc
J.
University of
Calgary
Cerebral blood flow regulation Sleep disordered breathing,
in obstructive sleep apnea.
chronic intermittent hypoxia,
cerebrovascular reactivity
testing, endothelial function,
stroke.
20062009
21,000
63,000
I,II,IV
Graham, Drew
Aaron
Rush, James
W.E.
University of
Waterloo
Mechanisms in vascular
nitric oxide bio-availability
in chronic hypertension and
exercise training.
Hypertension, exercise,
endothelial function, nitric
oxide, oxidative stress.
20052009
3,500
63,000
I
Hammoud, Lamis
Feng,
Qingping
University
of Western
Ontario
Role of TIMP-3 in heart failure
and postnatal cardiomyocyte
proliferation.
TIMP-3, myocardial
infarction, heart failure,
cardiomyocyte proliferation,
signal transduction.
20072009
21,000
42,000
I
Hines, Dustin J.
MacVicar,
Brian A.
University
of British
Columbia
Microglia cells limit the spread
of neurotrauma in a model of
stroke.
Stroke, microglia, twophoton microscopy, brain
vasculature, ion channels.
20072010
21,000
42,000
I,II
Iremonger, Karl J.
Bains,
Jaideep S.
University of
Calgary
Delayed glutamate release
allows central neurons
to function as efficient
integrators of synaptic inputs.
Hypothalamus, vasopressin,
synaptic integration, delayed
transmitter release.
20072010
21,000
49,000
I
Stroke, apoptosis, cell cycle,
cdks.
20062009
21,000
63,000
I
Iyirhiaro, Grace O. Park, David
S.
University of Role of Pin1 in reactivation of
Ottawa Heart cell cycle proteins following
Institute
stroke injury.
II: Clinical
Theme
49
Awardee
Supervisor
Institute
Project
Keywords
Term
08-09 $
Total $*
Theme
Jeyaraman,
Madhumathy
Kardami,
Elissavet
University of
Manitoba
Role of connexin43 in
protein kinase C mediated
cardioprotection.
Connexin43, protein
kinaseC, ischemia and CX43,
PKC and cardioprotection.
20052009
1,724
62,974
I
Kim, Minsuk
Rodrigues,
Brian B.
University
of British
Columbia
Metabolic basis for diabetic
heart disease: role of cardiac
lipoprotein lipase.
Diabetes, heart, fatty acids,
AMPK, lipoprotein lipase.
20082011
21,000
63,000
I
Kim, Paul Y.
Nesheim,
Michael E.
Queen's
University
A study of function and
regulation of factor Va.
Haemostasis, thrombosis,
factor V (a), activated protein
C, platelets.
20082010
21,000
24,500
I,II
Klein, Ran
deKemp,
Robert
University of Factor-analysis of dynamic
Ottawa Heart PET images for improved
Institute
quantification of myocardial
blood flow.
Positron emission
tomography, factor-analysis,
quantification, coronary artery
disease, myocardial blood
flow.
20082010
17,500
21,000
I,II
Kodiha,
Mohamed
Stochaj,
Ursula
McGill
University
Signaling through PI3 kinase
controls nuclear transport in
stressed cells.
Signal transduction, oxidative
stress, PI3 kinase, AMP kinase,
nuclear transport.
20072009
21,000
42,000
I
Lamont, Ryan E.
Childs,
Sarah J.
University of
Calgary
PlexinD1 signalling in the
developing zebrafish.
Angiogenesis, vascular
patterning, VEGF signalling.
20052009
3,500
63,000
I
Leduc, Martin
Chemtob,
Sylvain;
Heveker,
Nikolaus
Hôpital
SainteJustine
Dimerization of prostaglandin
E2 receptors.
Prostaglandin, receptors,
dimerization, ductus
arteriosus.
20072009
21,000
42,000
I
Leung, General
Moody,
Alan;
Wright,
Graham A.
Sunnybrook
Health
Sciences
Centre
Magnetic resonance imaging
of vulnerable plaque in the
coronary artery tree.
Magnetic resonance, heart
attack, vulnerable plaque.
20062009
21,000
63,000
I,II
Liang, Wenbin
Ward,
Michael E.;
Backx, Peter
H.
St. Michael's
Hospital
The role of chloride channels
in hypoxia induced pulmonary
hypertension.
Hypoxia, human pulmonary
atrery smooth muscle,
chloride channels.
20062009
21,000
63,000
I
Linte, Cristian A.
Peters,
Terence M.
Robarts
Research
Institute
Techniques for image
guidance and navigation of
minimally invasive off-pump
intra-cardiac interventions.
Minimally-invasive cardiac
interventions, imageguided surgery and therapy,
pre-operative procedure
planning, virtual reality
augmentation, intra-operative
guidance and navigation.
20082012
17,500
63,000 I,II,III,IV
Liu, Zhen
Yang,
Decheng
St. Paul's
Hospital
IGTP-induced PI3K/
Akt signaling pathway in
coxackievirus B3-caused
myocarditis and dilated
cardiomyopathy.
Interferon-y-inducible
GTPase, PI3K/Akt pathway,
caxsackievirus B3,
myocarditis.
20062009
21,000
63,000
I
Ljubicic, Vladimir
Hood, David York
A.
University
Effect of physical activity on
the apoptotic susceptibility of
the aged heart.
Mitochondria, aging, cardiac
muscle, apoptosis.
20052009
3,500
63,000
I,II
Mattar, Pierre A.
Schuurmans, University of
Carol J.
Calgary
Enhancing neurogenesis
for stroke repair using
neurogenin 2.
Stem cells, neurons,
differentiation, neurogenin.
20072009
21,000
42,000
I
50
Institute
Project
Keywords
Term
08-09 $
Total $*
Nagareddy,
McNeill,
Prabhakara Reddy John H.;
MacLeod,
Kathleen M.
Awardee
Supervisor
University
of British
Columbia
Mechanisms of vascular
dysfunction in diabetes, role
of nitrosative stress.
Diabetes, nitric oxide,
cardiovascular dysfunction,
blood pressure, nitrosative
stress.
20062009
21,000
63,000
I
Ramer, Leanne
Krassioukov,
Andrei V.;
Steeves,
John
University
of British
Columbia
The role of peripheral
plasticity in episodic
hypertension following spinal
cord injury.
Autonomic dysreflexia,
blood pressure, sympathetic
neurons, sensory neurons,
spinal cord injury.
20082011
10,500
42,000
I
Ronald, John A.
Rutt, Brian
K.; Hegele,
Robert A.
Robarts
Research
Institute
Magnetic resonance
imaging of a rabbit model of
atherosclerosis.
Atherosclerosis, cholesterol,
rabbit, magnetic resonance
imaging, contrast agents.
20052009
10,500
63,000
I
Rueda-Clausen,
Christian F.
Davidge,
Sandra T.
University of
Alberta
Effects of hypoxia-induced
intrauterine growth restriction
on cardiac function and
metabolism in adult offspring.
Fetal, hypoxia, cardiac,
metabolism, ischemia/
reperfusion.
20082011
21,000
63,000
I,II,IV
Sankaralingam,
Davidge,
Sowndramalingam Sandra T.
University of
Alberta
The roles of arginase and
LOX-1 in the pathophysiology
of preeclampsia.
Preeclampsia, pregnancy,
oxidative stress, nitric oxide,
endothelium.
20072009
21,000
42,000
I
Sauvageau,
Stéphanie
Thorin, Eric
Institut de
cardiologie
de Montréal
Functional characterization
of the dimerization and
intracellular trafficking of
endothelin receptors.
Endothelin receptors,
heterodimerization,
intracellular trafficking,
endothelin antagonists,
pulmonary hypertension.
20062009
18,577
60,577
I
Small, Theodore
W.
Pickering, J.
Geoffrey
Robarts
Research
Institute
The role of Wilms’ tumour
1-associating protein in
vascular remodeling.
Vascular smooth muscles
cells (VSMC), survival,
alternative pre-mRNA
splicing, remodeling, Wilms’
tumor 1-associating protein
(WTAP).
20082010
21,000
42,000
I
Smith, Pauline M.
Ferguson,
Alastair V.
Queen's
University
Adiponectin acts at the
area postrema to influence
cardiovascular control.
Hypertension, adiponectin,
cellular mechanisms, area
postrema, cardiovascular
control.
20072009
19,250
40,250
I
Stachniak, Tevye
J.
Bourque,
Charles W.
Montreal
General
Hospital
Neuropeptide modulation
of osmosensory transmission
from OVLT to SON.
Electrophysiology,
osmosensory, supraoptic,
synaptic, angiotensin.
20082010
21,000
42,000
I,II
Tai, Chao
MacVicar,
Brian A.
University
of British
Columbia
R-type VGCC's and TRP
channels contribute to strokeinduced neuronal death.
OGD, muscarinic,
metabotropic, TRP channels,
VGCCs.
20072009
21,000
42,000
I
Tyrrell, Pascal N.
Silverman,
Earl D.
Hospital for
Sick Children
Inflammation and
atherosclerosis in pediatric
rheumatic disease.
Atherosclerosis, lipid,
rheumatic disease, children,
epidemiology.
20082011
21,000
63,000
II
University
of British
Columbia
Androgen-dependent
regulation of arachidonic acid
metabolism influences the
development of hypertension
following insulin resistance.
Insulin resistance,
hypertension, sex
hormones, endothelium
derived hyperpolarizing
factor (EDEF),
20-hydroxyeicosatetranoic
acid (20-HETE).
20062009
21,000
63,000
I
Vasudevan, Harish McNeill,
John H.;
Rodrigues,
Brian B.
II: Clinical
Theme
51
Awardee
Supervisor
Institute
Project
Keywords
Term
08-09 $
Total $*
Voronova,
Anastassia
Skerjanc,
Ilona S.
University of
Ottawa
Characterization of Gli2
transcription factor in cardiac
muscle cell development.
Stem cells;
cardiomyogenesis;
transcription factor networks;
protein-protein interactions;
mass-spectrometry.
20082011
21,000
63,000
I
Wang, Huajin
Lehner,
Richard
University of
Alberta
Role of triacylglycerol
hydrolase and apolipoprotein
E in hepatic lipid droplet
metabolism.
Triacylglycerol hydrolase,
lipid droplet, apolipoprotein
E, VLDL assembly, TG
mobilization.
20082010
21,000
29,750
I
Wassef, Hanny
Davignon,
Jean
Clinical
Research
Institute of
Montreal
The role of apolipoprotein C-I
in adipose tissue.
Adipocyte, apolipoprotein
C-I, fatty acid metabolism,
adipokine, oxidation.
20062009
21,000
63,000
I,II
Wiles, Andrew D.
Peters,
Terence M.
Robarts
Research
Institute
Navigation accuracy models
for intracardiac minimally
invasive surgery.
Intracardiac surgical
navigation, spatial tracking
systems, navigation accuracy
models, target registration
error, real-time uncertainty
feedback.
20082010
21,000
42,000
I,II
Yacoub, Daniel
Merhi, Yahye Institut de
cardiologie
de Montréal
Implication de la P-sélectine
dans l'athéro-thrombase.
Plaquettes, agrégation,
thrombose, signalisation,
P-sélectine.
20072010
21,000
63,000
I
Zhou, Ning
MacVicar,
Brian A.
Signaling pathways underlying
spreading depression and
ischemic depolarization.
Spreading depression,
ischemia, cellular swelling,
excitotoxicity, mitochondria.
20072010
21,000
52,500
I
University
of British
Columbia
Theme
52
Research Fellowships
Awardee
Supervisor
Institute
Project
Keywords
Term
08-09 $
Total $*
Bousette,
Nicolas
Gramolini,
Anthony O.
University of
Toronto
Lentivirus mediated transgene
expression for cardiac
phenotype rescue.
Proteomics, dilated,
hypertrophic,
cardiomyopathy lentivirus.
20082010
40,000
80,000
I
Brown, Robert J. Rader,
Daniel J.
University of
Pennsylvania
Characterization of endothelial
lipase exon variants associated
with elevated HDL cholesterol.
Polymorphisms, adenoassociated virus,
atherosclerosis, lipoproteins,
lipases.
20062009
20,000
80,000
I
Chahine, Mirna
Pierce,
Grant N.
St. Boniface
Nuclear protein import
G.H. Research in vascular cells during
Centre
pathological states.
Nucleus, gene expression,
atherosclerosis, smooth
muscle cells, macrophages.
20072009
40,000
80,000
I
Chan, Matthew
W.C.
McCulloch, University of
Christopher Toronto
A.G.
Regulation of myofibroblast
differentiation by mechanical
loading.
Cardiac hypertrophy, force,
smooth muscle actin, small
GTPases, fibrosis.
20072010
50,000
150,000
I
Theme
Chen, Vincent C. Naus,
Christian
C.G.;
Foster,
Leonard J.
University
of British
Columbia
Investigating neuroprotective
roles of gap junctions by
functional proteomics.
Functional proteomics, gap
junctions, neuroprotection.
20082010
40,000
80,000
I
Cooper, Dawn
M.
Granville,
David J.
St. Paul's
Hospital
Targeting granzyme B as
a therapeutic approach to
atherosclerosis.
Atherosclerosis, granzyme B,
apoptosis, siRNA.
20082010
40,000
80,000
I
Denis, Maxime
Seidah,
Nabil G.
Ottawa
Health
Research
Institute
The role of ABCA1 in
Atherosclerotic chronic
inflammation.
Cell biology, lipoprotein,
signalling, inflamation,
macrophages.
20082010
40,000
80,000
I
Dong, Zhifang
Wang, Yu
Tian
University
of British
Columbia
Investigation into molecular
mechanisms mediating
excitotoxicity - developing
novel strategies in stroke
treatment.
Stroke, NDMA receptors,
ischemia, neuroprotection,
excitotoxicity.
20082009
36,756
36,756
I
Duhamel, Todd
A.
Dhalla,
Naranjan S.
St. Boniface
Characterization of disease
G.H. Research mechanisms associated with
Centre
diabetic cardiomyopathy
induced by type 2 diabetes.
Diabetic cardiomyopathy,
cardiovascular disease,
cellular remodelling,
calcium regulation, protein
phosphorylation.
20062009
6,667
80,000
I
Ebrahimian,
Talin
Schiffrin,
Ernesto L.
Lady Davis
Institute
for Medical
Research
Role of p38 MAP kinase and
MK 2 pathway in angitensin
II-induced vascular inflammation
in hypertension.
Inflammation, angiotensin II,
p38MAP kinase, MAP kinase
activating protein kinase 2,
hypertension.
20082009
40,000
40,000
I
Farkas, Attila S.
Nattel,
Stanley
Montreal
Heart
Institute
The role of intracellular
Isolated heart, arrhythmia,
Ca2+ abnormalities in the
Ca transient, Ca handling,
development of torsade de
torsades de pointes.
pointes in isolated rabbit hearts.
20082011
20,000
80,000
I
II: Clinical
53
Awardee
Supervisor
Institute
Project
Keywords
Term
Gao, Su
Lopaschuk,
Gary D.
University of
Alberta
Hypothalamic malonyl-CoA
regulation of heart fatty acid
and glucose oxidation in
ischemic heart disease.
Hypothalamus,
AMP-activated protein
kinase, malonyl-CoA,
malonyl-CoA decarboxylase,
heart muscle.
Germain, Marc
Slack, Ruth
S.
Ottawa
Health
Research
Institute
MCL-1, a regulator of
autophagic cell death after
stroke.
Giguere, Patrick
Siderovski,
David P.
University
of North
Carolina
Hale, Taben M.
deBlois,
Denis
Hannan,
Johanna L.
08-09 $
Total $*
20082010
40,000
80,000
I
Apoptosis, mitochondria,
autophagy,
neurodegeneration.
20082009
40,000
40,000
I
Development of novel
peptide-based biosensors and
perturbagens for the galphaq
subunit nucleotide cycle.
Appareil cardiovasculaire,
transduction du signal,
recepteurs couples aux
proteines G, regulateurs de
signalisation des proteines G
(RGS), proteine galphaq.
20072010
40,000
100,000
I
Université de
Montréal
Therapeutic apoptosis confers
long-term protection against
target organ damage.
Apoptosis, hypertension,
stroke, myocardial infarction,
fibrosis.
20062009
6,667
76,667
I
Webb, R.
Clinton
Medical
College of
Georgia
The inhibition of RhoA/
Rho-kinase by nitric oxide in
erectile function in rats.
Sexual dysfunction, nitric
oxide, RhoA/Rho-kinase,
hypertension.
20082011
20,000
80,000
I
Hegle, Andrew
Accili, Eric
A.
University
of British
Columbia
Glycosylation and subunit
assembly of hyperpolarizationactivated cyclic nucleotidegated (HCN) pacemaker
channels.
Pacemaker, ion
channels, glycosylation,
heteromerization,
electrophysiology.
20082011
20,000
80,000
I
Heit, Bryan J.
Grinstein,
Sergio
Hospital for
Sick Children
Role of CD36/co-receptors
nanoclusters and their role
in the uptake of low-density
lipoproteins.
CD36, low-density
lipoprotein, macrophage,
nanoclusters, atherosclerosis.
20082010
40,000
80,000
I
Hodge, Rebecca Hevner,
D.
Robert F.
University of
Washington
Capacity of Tbr2-positive
progenitors to promote
regeneration in the injured adult
brain.
Transcription factors, adult
neurogenesis, endogenous
progenitors, brain injury,
brain repair.
20072009
40,000
80,000
I
Hunter, Arwen L. Cooke,
John P.
Stanford
University
Pro-angiogenic signaltransduction following
endothelial nicotinic
acetylcholine receptor (nAChR)
activation.
Angiogenesis, nicotine,
acetylcholine, cell
signalling, nAChR (nicotinic
acetylcholine receptor).
20082010
40,000
80,000
I
Jegatheeswaran, McCrindle,
Anusha
Brian W.
Hospital for
Sick Children
Creating a validated risk score
to predict outcomes following
Cardiac surgery, congenital
heart disease, epidemiology,
intensive care, risk modeling.
20082011
50,000
150,000
II
20082010
40,000
80,000
I
congenital cardiac surgery.
Jones, Peter P.
Chen, S. R.
Wayne
University of
Calgary
Molecular mechanism of cardiac Cardiac arrythmias and
ryanodine receptor regulation
sudden death, ryanodine
by casein kinase 2 (CK2).
receptor, phosphorylation,
genetic mutations,
transgenic animals.
Theme
54
Awardee
Supervisor
Institute
Project
Keywords
Term
Karasinska,
Joanna Monika
Hayden,
Michael R.
University
of British
Columbia
Role of neuronal and glial
ABCA1 in the response to
neuronal injury.
Cholesterol, ATP-binding
cassette transporter, brain
lipid metabolism, neuronal
repair, animal model.
Karki, Pratap
Fliegel,
Larry
University of
Alberta
Role and regulation of the Na+/
H+ exchanger in myocardial cell
death.
Kaun, Karla R.
Heberlein,
Ulrike
University of
California San
Francisco
Kilic, Ana
Karmazyn,
Morris
University
of Western
Ontario
Kim, Hugh
08-09 $
Total $*
20062009
6,667
80,000
I
Apoptosis, Na+/H+
exchanger, ischemia,
acidosis.
20082010
40,000
80,000
I
The genetics of alcoholism:
genetic, molecular, and
neuroanatomical dissection of
ethanol addiction in drosophila
melanogaster.
Addiction, alcoholism,
genes, neural mechanisms,
fruit flies.
20082011
40,000
100,000
I
Dual and opposite effects of
estradiol on intracellular pH
and cell size in male and female
adult rat cardiomyocytes.
Heart failure and
hypertrophy, gender
differences, cardiac
remodeling, Na+/H+
exchanger, estrogen.
20082010
40,000
80,000
I
McCulloch, University of
Christopher Toronto
A. G.
Mechanically induced cardiac
fibrosis: role of cytoskeleton in
mechanoprotection.
Mechanotransduction,
cytoskeleton, MAP kinases,
calcium signaling, filamin.
20082010
50,000
100,000
I
Laroche,
Genevieve
Siderovski,
David P.
University
of North
Carolina
Functional studies of receptorselectivity determinants in RGS
proteins in the cardiovascular
system.
Functional studies of
receptor-selectivity
determinants in RGS
proteins in the cardiovascular
system.
20082010
40,000
80,000
I
Lemarie,
Catherine A.
Schiffrin,
Ernesto L.
Sir Mortimer
B. Davis
Jewish
General
Hospital
AT1 receptors are essential
in aldosterone signaling in
VSMC and impairment of EPCs
differentiation.
Hypertension, angiotensin
receptors, aldoserone,
vascular dysfunction.
20072009
40,000
80,000
I
Li, Hongliang
Liu, Peter P.
University of
Toronto
Roles of A20 signaling on heart
failure mediated by myocarditis
& cardiac hypertrophy.
Heart failure, myocarditis,
cardiac remodeling,
transgenic knockout model,
innate immunity.
20072009
40,000
80,000
I,II
Li, Shupeng
Liu, Fang
University of
Toronto
Identification of a protein
peptide in the treatment of
ischemic stroke.
NMDA receptors, mGlur
receptors, excitotoxicity,
protein-protein interaction,
stroke.
20082010
40,000
80,000
I
Machha, Ajay
Wang, Rui
Lakehead
University
Hydrogen sulfide, nitric oxide,
hypertension, endothelial cells.
Hydrogen sulfide, nitric
oxide, hypertension,
endothelial cells.
20082009
14,491
14,491
I
McGowan, Cheri Floras,
L. M.
John S.
University of
Toronto
Cholesterol - independent
effects of HMG- CoA reductase
inhibitor therapy on neural
control of the heart and
circulation in heart failure.
Statins, congestive heart
failure, microneurography,
heart rate variability,
endothelial function.
20072009
40,000
80,000
II
Mekhail, Samy
Makary
Montreal
Heart
Institute
Mechanisms of IKACh channel
remodelling in atrial fibrillation.
Acetylcholine, arrythmia,
ion channel, remodelling,
gating.
20082010
40,000
80,000
I
Nattel,
Stanley
II: Clinical
Theme
55
Awardee
Supervisor
Institute
Project
Keywords
Term
Mente, Andrew
Anand,
Sonia S.
McMaster
University
Nutrigenomics and
cardiovascular disease.
Nutrigenomics, single
nucleotide polymorphisms,
dietary patterns,
interheart genetic study.
Mochizuki,
George
McIlroy,
William E.
Toronto
Rehabilitation
Institute
Mechanisms involved in
the execution of protective
responses following sudden,
unexpected perturbations.
Morton, Jude S.
Davidge,
Sandra T.
University of
Alberta
Nader, Moni
Tuana,
Balwant S.;
Leenen,
Frans H.H.
Naus, Silvia
08-09 $
Total $*
Theme
20072009
40,000
80,000
II,IV
Stroke, brain imaging,
sensorimotor recovery,
rehabilitation.
20072009
40,000
80,000
I,II
Effects of maternal hypoxia on
vascular function in relation to
gender and aging in rats.
Cardiovascular, aging,
intrauterine growth
restriction, endothelium,
hypoxia.
20072010
40,000
80,000
I
University of
Ottawa
Potential role of SLMAP in
regulating the excitationcontraction apparatus during
heart remodeling.
SLMAP, excitationcontraction coupling,
membranes organization,
apoptosis, proliferation.
20072009
40,000
80,000
I
Ziltener,
Hermann J.
University
of British
Columbia
The role of metalloproteases in
the leukocyte homing process.
Metalloproteases, ADAM,
mucin-like receptors,
immune cells.
20062009
20,000
80,000
I
Nicolescu,
Adrian C.
Davies,
Peter L.
Queen's
University
Post-translational modification
and regulation of matrix
metalloproteinase-2 in
myocardial ischemia/
reperfusion.
Heart, matrix
metalloproteinases,
peroxynitrite, posttranslational modification,
proteomics.
20082010
40,000
80,000
I
Panama, Brian
K.
Backx,
Peter H.
University of
Toronto
Molecular regulation of cardiac
K+ channels and excitability.
Potassium channels,
electrophysiology, heart
disease, arrhythmias,
contraction, calcium.
20082011
35,000
80,000
I
Ribeiro, Fabiola
M.
Ferguson,
Stephen
S.G.
Robarts
Research
Institute
Effect of optineurin and GRK2
knockdown on metabotropic
glutamate receptor signalling
and excitotoxic cell death.
Excitotoxicity, GRK2,
mGluR5, optineurin,
neurons.
20072009
40,000
80,000
I
Rousselet,
Estelle
Seidah,
Nabil G.
Institut de
recherches
cliniques de
Montréal
Role of PCSK9 in mice model of
ischemic stroke.
Ischemic stroke,
PCSK9 knockout mice,
neurogenesis, cell
differentiation, apoptosis.
20072010
40,000
100,000
I,II
Saini-Chohan,
Harjot K.
Hatch,
Grant M.
University of
Manitoba
Mitochondrial DNA absence
sensitive factor (MIDAS)
mediated regulation of
cariolipin biosynthesis.
Cardiolipin, heart,
mitochondria, metabolism,
phospholipids.
20082010
40,000
80,000
I
Santosa, Sylvia
Jensen,
Michael D.
Mayo Clinic
Sex hormone effects on free
fatty acid kinetics and uptake by
adipocytes.
Meal fatty acid uptake, fat
distribution, adipocyte, fatty
acid kinetics, sex hormones.
20072009
22,751
42,751
I,II
So, Christopher
Benovic,
Jeffrey L.
Thomas
Jefferson
University
Functional characterization of G
protein-coupled receptor kinases
in the nucleus.
Nucleus, G protein
coupled receptor kinase,
phosphorylation, proteinprotein interactions, protein
trafficking.
20082010
40,000
80,000
I
56
Awardee
Supervisor
Institute
Project
Keywords
Term
08-09 $
Total $*
Theme
Tang, Guanghua Wu,
Lingyun
(Lily)
University of
Effects of methylglyoxal on
Saskatchewan ATP-sensitive K+ channels
and underlying mechanisms in
vascular smooth muscle cells.
Methylglyoxal, ATPsensitive K+ channels,
vascular smooth muscle
cells, oxidative stress,
hypertension.
20082010
40,000
80,000
I
Varady, Krista A.
Hellerstein,
Marc
University of
California,
Berkeley
Effect of daily calorie restriction
of alternate-day fasting
regimens on adipose tissue
physiology and coronary heart
disease risk.
Calorie restriction,
alternate-day fasting,
coronary heart disease
prevention, adipose tissue
physiology, obese humans.
20082009
40,000
40,000 I,II,III,IV
Varela Lekanda,
Diego Ernst
Zamponi,
Gerald W.
University of
Calgary
Molecular determinants
Biophysics,
of T-type calcium channel
electrophysiology, calcium
inactivation and its physiological channel.
significance.
20062009
6,667
80,000
I
Westendorp,
Bart
Tuana,
Balwant S.;
Leenen,
Frans H.H.
University of
Ottawa
E2F6: essential regulator of
cardiac growth?
Heart failure, cardiac
regeneration, cell cycle
regulation, molecular
biology techniques, E2F
transcription factors.
20072009
6,667
46,667
I
Xu, Guoxiong
Letarte,
Michelle V.
Hospital for
Sick Children
Studying the role of BMP- 9 in
vascular homeostasis through
disease models.
Hypertension,
telangiectasia, vasculature,
TGF - beta, BMP-9.
20072010
40,000
80,000
I
Zhang, Liyan
Lopaschuk,
Gary D.
University of
Alberta
Cardiac lipotoxicity in obesity
and diabetes.
Cardiac energy metabolism,
obesity, fatty acids,
cardiotoxicity, diabetes.
20082010
40,000
80,000
I
New Investigators
Awardee
Institute
Project
Keywords
Term
Ahern,
Christopher
A.
University
of British
Columbia
Investigating anti-arrhythmic inhibition
of voltage-gated sodium channels
with unnatural amino acids and
fluorescence spectroscopy.
Arrhythmia, pacemaking, stroke,
biophysics, pharmacology.
20082013
75,000
315,000
I,II
Anderson,
Christopher
M.
University of
Manitoba
PARP1 effects on bioenergetics and
glutamate homeostasis in brain.
Poly(ADP-ribose) polymerase,
excitotoxicity, astrocytes, glutamate
transport.
20052010
50,000
250,000
I
Barber, Philip University of
A.
Calgary
Magnetic resonance molecular
imaging (MRMI) of the early
endothelial inflammatory response in
focal ischemia.
Stroke, magnetic resonance imaging,
neuroinflammation.
20052010
50,000
265,000
I
Bolz, Steffen- University of
Sebastian
Toronto
The control of microvascular tone
by the Sphingosine-1-phosphate
signalling pathway.
Microcirculation, arteries, transfection,
smooth muscle, sphingosine-1phosphate signalling.
20082013
60,000
300,000
I
Bonnet,
Sébastien
Dehydroepiandrosterone reverses
vascular remodeling diseases.
Vascular remodeling diseases,
dehydroepiandrosterone, apoptosis,
potassium channels, PI3K pathway.
20082010
55,000
115,000
I
Genetic susceptibility to calcific aortic
valve stenosis.
Aortic stenosis, candidate genes,
genomics, microarray, genotyping.
20082013
60,000
300,000
I,II
University of
Alberta
Bossé, Yohan Université de
Laval
II: Clinical
08-09 $
Total $*
Theme
57
Awardee
Institute
Project
Keywords
Butcher,
Ken S.
University of
Alberta
Cerebral perfusion and blood pressure Stroke, intracerebral hemorrhage,
in intracerebral hemorrhage: a safety
perfusion, blood pressure,
study.
antihypertensives.
20072009
33,333
98,333
II
Chelikani,
Prashen
V.G.B.
University of
Manitoba
Towards the elucidation of beta2adrenergic receptor structure.
G-protein coupled receptors (GPCR's),
membrane protein structure,
NMR spectroscopy, receptor-drug
interactions, molecular modeling.
20082013
60,000
300,000
I
Claydon,
Thomas W.
Simon Fraser
University
Structural dynamics of hERG
potassium channel gating studied
using voltage clamp fluorimetry.
Electrophysiology, voltage clamp
fluorimetry, ion channels, hERG,
cardiac.
20082013
60,000
300,000
I
Colicos,
Michael A.
University of
Calgary
Role of neuroligin during
photoconductive stimulation-driven
synaptic reorganization of mammalian
neuronal networks.
Ischemia, synaptic reorganization,
neuronal cultures, neurosilicon
interface, neuroligin.
20062011
50,000
265,000
I
Czubryt,
Michael P.
University of
Manitoba
Roles of MEF2 and HDAC5 in cardiac
failure and hypertrophy.
Transcriptional regulation, cardiac
hypertrophy, molecular biology, sexual
dichotomy, transgenic mice.
20042009
50,000
265,000
I
Dawson,
John F.
University of
Guelph
Characterization of human cardiac
actin mutations linked to hypertrophic
and dilated cardiomyopathies.
Cardiac actin mutations, hypertrophic
and dilated cardiomyopathy, protein
expression and manipulation, actin
binding assays.
20042010
50,000
250,000
I
Devlin,
Angela M.
University
of British
Columbia
Nutrition, epigenetics & risk for
Hyperhomocysteinemia, DNA
methylation, mice, nutrition, gene
expression.
20062011
50,000
265,000
I,II,IV
Drolet,
Benoit
Université
Laval
The modulating effects of diabetes,
obesity and genetics on the
electrophysiology of QT-prolonging
drugs.
Electrophysiology, obesity, diabetes,
patch-clamp, TW-prolonging drugs.
20042009
50,000
250,000
I
Feng,
Zhong-Ping
University of
Toronto
Modulatory mechanisms underlying
membrane targeting of cardiac
voltage-dependent calcium channels.
Calcium channel, surface expression,
gene expression, protein kinases,
cardiac myocytes.
20082013
60,000
300,000
I
Gramolini,
Anthony O.
University of
Toronto
Molecular basis of PLN regulation and
function in cardiac muscle.
Calcium, serca, mouse models,
phospholamban, cardiac, sarcoplasmic
reticulum.
20062011
50,000
250,000
I,II
Gros, Robert
Robarts
Research
Institute
Regulators of G-protein-coupled
Hypertension, G-protein-coupled
receptor-mediated vascular responses. receptor kinases, vascular cells,
knockdown, adenovirus.
20072012
50,000
250,000
I
Jassal,
Davinder S.
St. Boniface
G.H.
Research
Centre
The interaction of hyperlipidemia and
NOS3 on ventricular remodeling after
pressure-induced overload.
Chronic pressure overload, nitric
oxide, obesity, ventricular remodeling,
hyperlipidemia.
20082013
60,000
300,000
I
Kassiri,
Zamaneh
University of
Alberta
The MMP-dependent and MMPindependent functions of TIMP-2 in
heart disease.
Myocardial infarction, pressure
overload, remodeling, matrix proteins,
MMPs & TIMPs.
20082013
60,000
300,000
I
Term
08-09 $
Total $*
Theme
58
Awardee
Institute
Project
Keywords
Term
Liaw, Patricia
C. Y.
McMaster
University
Modulation of inflammation and
apoptosis by activated protein C, a
natural anticoagulant.
Coagulation, inflammation, apoptosis,
thrombosis, activated protein C,
vascular biology, endothelial cells,
blood monocytes, leukocytes, signal
transduction pathways, proteaseactivated receptors, biochemistry,
cell biology, molecular biology,
translational studies of patient blood
samples, in vivo animal models.
20032009
18,269
250,000
I
MacDonald,
Justin A.
University of
Calgary
Characterization of CHASM
involvement in cGMP-evoked calcium
desensitization in vascular smooth
muscle.
Calcium desensitization, smooth
muscle tone, nitric oxide, cGMPdependent protein kinase, signal
transduction.
20042009
50,000
250,000
I
Mak,
Susanna
Mount Sinai
Hospital
Estrogen and cardiac function in
humans with and without heart failure.
Sex, estrogen, ventricular function,
heart failure.
20052010
50,000
250,000
II
Melacini,
Giuseppe
McMaster
University
Structural basis for the cAMP-signal
translation in PKA by NMR.
Signalling, kinase, cAMP, allostery,
NMR.
20062011
50,000
250,000
I
Miller,
Gregory E.
University
of British
Columbia
Depression, inflammation, and risk for
coronary heart disease.
Depression, behavioral cardiology,
inflammation, coronary heart disease,
metabolic syndrome.
20052011
50,000
265,000
II,IV
Peng,
Tianqing
Lawson
Research
Institute
PLCgamma/IP3 signaling regulates
cardiac TNF-a expression in sepsis.
Sepsis, TNF-alpha, cardiomyocyte,
phospholipase Cgamma, inositol
trisphosphate.
20062011
50,000
250,000
I
Pyle, William
Glen
University of
Guelph
The role of cardiac Z-disc in signal
transduction and myocardium.
Actin capping protein, intracellular
signalling, muscle mechanics,
cytoskeleton, heart failure.
20052011
50,000
250,000
I
Sawicki,
Grzegorz
(Greg)
University of Chemical modifications of myosin
Saskatchewan light chain 1 in oxidative stress and its
degradation by MMP-2.
Oxidative stress, cardiovascular,
ischemia-reperfusion, proteinases,
proteomics.
20072012
50,000
250,000
I
Seubert,
John M.
University of
Alberta
Role of eicosanoids in the heart:
implications of arachidonic acid and its
metabolites in regulating myocardial
function and ischemic injury.
Eicosanoids, cytochrome P450
epoxygenases, ischemia-reperfusion
injury, potassium channels, natriuretic
peptides.
20072012
50,000
265,000
I
Shearer,
Jane
University of
Calgary
Mechanisms of glycogen-induced
insulin resistance in diabetic
cardiomyopathy.
Diabetes, cardiac function, glycogen,
metabolism, tracer.
20072013
50,000
250,000
I
Thompson,
Roger J.
University of
Calgary
A critical role for pannexin-1
hemichannels in excitotoxic neuronal
death.
Ischemia, NMDA receptor, necrosis,
patch-clamp, imaging.
20082013
75,000
315,000
I
Wang, Hao
London
Health
Sciences
Centre
Soluble CD83 based therapy in
cardiac allograft tolerance.
Heart transplantation, soluble CD83,
tolerance, dendritic cells, T regulatory
cells.
20082013
60,000
300,000
I
Werstuck,
Geoffrey H.
McMaster
University
Mechanisms by which diabetes
mellitus promotes the development
and progression of atherosclerosis.
Atherosclerosis, diabetes mellitus,
endoplasmic reticulum, molecular and
cellular biology, mouse models.
20042009
50,000
250,000
I
II: Clinical
08-09 $
Total $*
Theme
59
Awardee
Institute
Project
Keywords
Term
Yan, Andrew
T.
St. Michael's
Hospital
Impact of in-centre nocturnal
hemodialysis on ventricular
remodeling and function in end-stage
renal disease.
Ventricular remodeling, left ventricular
mass, cardiac magnetic resonance
imaging, end-stage renal disease,
hemodialysis.
20082014
08-09 $
Total $*
Theme
45,000
300,000
I,II
Theme
Nursing Research Fellowships
Awardee
Supervisor
Institute
Project
Keywords
08-09 $
Total $*
Beaulieu,
Dominique
Godin,
Gaston
Université
de Laval
Développement, implantation,
évaluation d'interventions pour
améliorer l'alimentation des
adolescents en milieu scolaire.
Évaluation, efficacité,
intervention, saine
alimentation, adolescents.
20082010
25,000
29,167
Houle, Julie
Poirier, Paul
Université
Programme d'Activité physique en
Réadaptation cardiaque Adapté et
Dirigé par une infirmière clinicienne
Spécialisée (projet PARADIS).
Coronaropathie,
réadaptation cardiaque,
observance, exercise,
infirmière.
20072010
25,000
50,000
II,III
University
of British
Columbia
How does early discharge following
elective same-day discharge
angioplasty affect patient outcomes?
Coronary artery disease,
percutaneous coronary
intervention (PCI), early
discharge, patient
outcomes.
20062009
25,000
75,000
II,III
Price, Jennifer Doran,
A.D.
Diane
University
of Toronto
Can structured-coaching increase
intake and uptake of cardiac
rehabilitation in female cardiac
patients?
Cardiac rehabilitation,
access, women.
20062009
25,000
75,000
II,III
Rombough,
Rosemarie E.
Brouwer,
Brenda
Queen's
University
Exercise induced changes in bone
health, muscle mass and function in
chronic stroke.
Stroke survivors,
rehabilitation, bone health,
quality of life, physical
conditioning, resistance
exercises.
20082009
10,417
10,417 I,II,III,IV
Routledge,
Faye S.
McFetridge- Dalhousie
Durdle,
University
Judith
24-hour hemodynamic assessment
of blood pressure dipping patterns
among premenopausal and
postmenopausal women.
Blood pressure patterns,
hemodynamics, women,
impedance cardiography.
20082011
20,833
50,000
II
Seneviratne,
Cydnee C.
King,
Kathryn
M.; Mather,
Charles M.
Interprofessional practices in cardiac
rehabilitation.
Cardiovascular,
rehabilitation,
interprofessional practice,
ethnography.
20072010
25,000
50,000
II,III
Term
08-09 $
Total $*
14,500
14,500
de Laval
Lauck, Sandra
B.
Johnson,
Joy
University
of Calgary
Term
Visiting Scientist
Awardee
Sponsor
Eskes, Gail A. Poulin, Marc
J.
Institute
Project
Keywords
University
of Calgary
Maximizing stroke outcome: effects of
sleep apnea on cognition and functional
recovery in patients with transient
ischemic attack (TIA) or minor stroke.
Cognition, stroke, sleep
apnea, functional outcomes,
recovery.
20082009
Theme
II
60
Industry-Supported Research Fellowship Awards
The HSF wishes to thank the following industry supporters for their generous contributions to support the HSF Research Program.
Awardee
Supervisor Institute
Project
Keywords
Term
HSF
Total 08-09 $
08-09 $ (All Partners)
HSF
Total $*
Total $
Theme
(All Partners)*
The role of integrinlinked kinase in
modulation of
vascular smooth
muscle migration
and atherosclerotic
intimal thickening
in type II diabetes.
Atherosclerosis,
diabetes type 2,
smooth muscle
cell migration,
actin cytoskeleton,
integrin-linked
kinase.
20072010
0
40,000
0
80,000
I
HSF/AstraZeneca Research Fellowship
Esfandiarei,
Mitra
van
Breemen,
Cornelis
Child and
Family
Research
Institute
Ghanem,
Noel
Slack, Ruth University Neural precursor
S.
of Ottawa cell mediated
regeneration in
the brain following
stroke.
Neurogenesis,
stem cells,
regeneration,
stroke.
20072009
0
40,000
0
80,000
I
Karwatsky,
Joel
Zha,
Xiaohui
The influence
of ATP-binding
cassette protein
A1 (ABCA1) on
cholesterol export.
Cholesterol,
coronary
heart disease,
membrane
trafficking, ABC
transporters,
ATP-binding
cassette protein A1
(ABCA1).
20062009
0
6,667
0
80,000
I
Keung,
Wendy W.
Lopaschuk, University Cardiac
Gary D.
of Alberta AMP-activated
protein kinase and
energy metabolism
in obesity.
Obesity, cardiac,
ischemia/
reperfusion, ampk,
metabolism.
20082010
0
40,000
0
80,000
I
Li, HaoDong
Michalak,
Marek
University Role of calreticulin
of Alberta in regulation of
lipid metabolism.
Endoplasmic
reticulum, lipid
metabolism,
calreticulin, sterol
regulatory element
binding protein,
transcription factor.
20072009
0
40,000
0
80,000
I
Overgaard,
Christopher
B.
Newton,
Gary E.
University
of
Toronto
Heart failure,
free radicals,
mechanical
efficiency.
20062009
25,000
25,000
100,000
150,000
II
Ottawa
Health
Research
Institute
Free radical
modulation
of mechanical
efficiency in heart
failure.
II: Clinical
61
Awardee
Supervisor Institute
Project
Keywords
Term
HSF
Total 08-09 $
08-09 $ (All Partners)
HSF
Total $*
Total $
Theme
(All Partners)*
HSF/Pfizer Canada Research Fellowship
Chakrabarti,
Subhadeep
Davidge,
Sandra T.
University AMPK and PPAR
of Alberta activators on
AGE-mediated
endothelial
dysfunction.
Diabetes,
endothelium, AGE,
PPAR, AMPK.
20072009
40,000
0
40,000
80,000
I
Helli, Peter
B.
Backx,
Peter H.
University
of
Toronto
The role of chloride
channels in
hypoxia-mediated
pulmonary vasoconstriction.
Pulmonary hypertension, hypoxia,
NADPH-oxidase,
PI3kinase-gamma,
chloride channels.
20082010
0
40,000
40,000
80,000
I
Rahmani,
Maziar
BrooksWilson,
Angela R.
B.C.
Cancer
Research
Centre
Genetics of healthy
cardiovascular
aging.
Healthy aging,
cardiovascular
aging, atherosclerosis, calcific aortic
valve steonsis,
single nucleotide
polymorphism,
SNP, genetic
association,
inflammation,
oxidative stress.
20072010
30,000
10,000
40,000
80,000
I,II
62
APPENDIX
C
GRANTS-IN-AID
Photo: Dr. Nasrin Mesaeli (St. Boniface G.H. Research Centre) was the recipient in 2008-2009 of a Grant-in-Aid from the Heart and Stroke Foundation of
Manitoba, titled “Regulation of cell proliferation by calreticulin”.
Institute of Principal
and Co-Investigator(s)
Investigator
Accili, Eric
University of
British Columbia
Interactions among pacemaker
channel isoforms and auxiliary
proteins.
Pacemaker channels,
co-assembly, cell surface
expression.
20062009
125,000
375,000
I,II
Accili, Eric
University of
British Columbia
Molecular regulation of
pacemaker channel function.
Pacemaker channels, structure,
function, human, regulation
20072010
80,000
160,000
I
Boyd, Lara; Eng,
University of
British Columbia
Promotion of brain reorganization
after stroke.
Stroke, human, brain,
rehabilitation.
20082011
76,650
76,650
I,II
University of
British Columbia
The structure of gelsolin-capped
actin filaments.
Actin, gelsolin, cytoskeleton,
protein crystallography,
protein structure.
20082011
101,238
101,238
I
Claydon, Thomas W. Simon Fraser
University
Structural dynamics of hERG
potassium channel gating studied
using voltage clamp fluorimetry.
Electrophysiology, voltage
clamp fluorimetry, ion
channels, hERG, cardiac.
20082011
111,717
111,717
I
Claydon, Victoria
Elizabeth; McGrath,
Maureen S.
Simon Fraser
University
Cerebrovascular control following
spinal cord injury.
Blood pressure, cerebral
autoregulation, spinal cord,
injury, autonomic dysreflexia,
orthostatic hypotension.
20082011
62,297
62,297
II
Devlin, Angela M.
University of
British Columbia
Hyperhomocysteinemia &
epigenetic regulation of hepatic
lipid metabolism.
Hyperhomocysteinemia,
nutrition, gene expression,
DNA methylatron, fatty acids.
20072010
120,000
240,000
I,II,IV
Eng, Janice; Miller,
William C.; Dawson,
Andrew S.
University of
British Columbia
Exercise programs in stroke Effect of an inpatient
supplementary practice program
on upper extremity function in
stroke rehabilitation.
Rehabilitation, health services,
upper extremity function,
exercise, recovery.
20062009
112,192
336,576
III
Fedida, David;
Arbour, Laura T.
University of
British Columbia
Further studies of KCNQ1
long-QT mutations present
in a Canadian First Nations
population.
Long QT syndrome, potassium
channel, heart, arrythmia,
electrophysiology.
20082011
145,524
145,524
I,II,IV
Fedida, David
University of
British Columbia
Activation and inactivation
gating of cardiac voltage-gated
potassium channels studied by
electrophysiology and timeresolved fluorescence changes.
Potassium channel, heart,
fluorescence, arrhythmia,
electrophysiology.
20062011
148,495
453,834
I
Fedida, David
University of
British Columbia
Contribution of the dynein motor
system to surface expression and
subcellular localization of voltagegated potassium channels.
Potassium channel, heart,
dynein motor, arrhythmia,
electrophysiology.
20052010
122,740
495,840
I
Granville, David
St. Paul's Hospital
Granzyme B in atherosclerosis and Apoptosis, atherosclerosis,
xanthomatosis.
granzyme B, extracellular
matrix, inflammation.
20072010
99,550
199,100
I
Hayden, Michael R.
University of
British Columbia
The functional role of
palmitoylation of ABCA1 and its
effects on HDL metabolism and
atherosclerosis.
20072010
106,328
226,477
I
Janice
Burtnick, Leslie
Project
Term
Cumulative
Theme
$ to 2009
64
Keywords
08-09 $
Principal Investigator
Palmitoylation, ABCA1,
HDL-cholesterol, efflux, heart
disease.
Investigator
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
Humphries, Karin
St. Paul's Hospital
H.; Gao, Min; Norris,
Colleen M.; Pilote,
Louise; Singer, Joel
Sex differences and determinants
of health status post-acute
myocardial infarction in younger
adults.
Sex differences, acute
myocardial infarction, quality
of life, process of care,
psychosocial.
20082011
135,535
135,535
II,III
Johnson, Pauline
University of
British Columbia
To investigate the pro- and antiinflammatory functions of CD44
and hyaluronan.
Inflammation, cell adhesion
molecules, CD44, hyaluronan,
macrophages.
20062009
80,490
200,980
I
Karsan, Aly; Marra,
Marco; Hoodless,
Pamela; Jones,
Steven
B.C. Cancer
Agency
Dissecting gene regulatory
networks in cardiac cushion
development.
20072010
125,090
250,180
I
Karsan, Aly
B.C. Cancer
Agency
Mechanisms of ischemic
neovascularization.
Endothelial cells, vascular
smooth muscle, endothelialmesenchymal transformation,
notan, snail.
20042009
108,470
538,122
I
Karsan, Aly
B.C. Cancer
Agency
Molecular mechanisms of
endothelial survival/apoptosis.
Apoptosis, endothelium,
notch, signal transduction,
vascular injury.
20062011
125,907
380,940
I
Khan, Nadia; Hill,
Michael D.; Hsiung,
Ging-Yuek R.;
Humphries, Karin
H.; Kapral, Moira
K.; McAlister, Finlay
A.; Palepu, Anita;
Pilote, Louise;
Quan, Hude
St. Paul's Hospital
Sex and ethnic differences in
stroke prognosis and quality of
care.
Ethnicity, stroke, administrative
data, sex, mortality.
20082011
51,880
51,880
II,III
Krassioukov, Andrei;
Ramer, Matt S.;
Norenberg, Michael
D.
University of
British Columbia
Episodic hypertension following
spinal cord injury: The role of
peripheral sympathetic-sensory
interactions in animal models and
humans.
Autonomic dysreflexia, blood
pressure control, human,
sympathetic preganglionic
neurons, spinal cord injury.
20062009
66,612
209,077
I
Laher, Ismail
University of
British Columbia
Lifestyle modifications improve
coronary artery function in type 2
diabetes.
Diabetes, endothelium,
superoxides, coronary artery,
mouse.
20062009
87,528
262,584 I,II,III,IV
Lear, Scott;
Bates, Joanna;
Ignaszewski,
Andrew; Prkachin,
Kenneth
St. Paul's Hospital
Randomized trial of a cardiac
rehabilitation program delivered
remotely through the Internet.
Cardiac rehabilitation, internet,
telehealth.
20072010
76,230
196,780
II,III
Luo, Honglin
St. Paul's Hospital
Mechanisms of impaired cardiac
function in coxsackievirus-induced
myocarditis.
Coxsackievirus, viral
myocarditis, serum response
factor, heart failure, cardiac
contractility.
20082011
86,900
86,900
I
Luo, Honglin
St. Paul's Hospital
The ubiquitin/proteasome system
in cardiac remodelling.
Ubiquitin/proteasome
system, cardiac remodelling,
proteolysis, heart failure,
ischemic heart disease.
20072010
101,000
214,000
I
II: Clinical
65
Project
Investigator
MacVicar, Brian
University of
British Columbia
Cellular mechanisms underlying
ischemia induced neuronal
necrosis.
Brain slice, necrosis, parinexin,
TRP chanel, intracellular,
calcium.
20062009
106,500
319,500
I
McManus, Bruce;
Luo, Honglin
St. Paul's Hospital
Intracellular signalling networks in
cardiotropic enteroviral infections.
Coxsackievirus B3, intracellular
signalling networks,
extracellular signal-regulated
kinase, viral myocarditis,
proinflammatory cytokine.
20062009
100,400
301,200
I
McNagny, Kelly
University of
British Columbia
Role of endoglycan in
hematopoiesis, vascular biology
and cancer.
CD34, adhesion, vascular
permeability, endothelial cell
differentiation, endoglycan.
20072010
134,100
268,200 I,II,III,IV
McNeill, John H.
University of
British Columbia
Modulation of cardiac metabolism
by metoprolol in the diabetic
heart.
Cardiomyopathy, heart
failure, cardiac metabolism,
B-blockers, diabetic
complication.
20062009
107,809
323,427
I
Moore, Edwin
University of
British Columbia
The structure of excitationcontraction coupling in atrial and
ventricular muscle.
20062009
8,000
24,000
I
Murphy, Timothy
University of
British Columbia
Using in vivo imaging to resolve
if, when, and where excitoxicity
and oxidative stress occur during
stroke.
Stroke, in vivo, imaging,
dendrite, calcium.
20072010
113,422
226,844
I
Naus, Christian;
Krebs, Claudia
University of
British Columbia
Gap junctions and
neuroprotection in stroke.
Gap junctions, transgenic,
knockout, connexin, stroke.
20052010
87,000
344,602
I
Pang, Catherine C.Y. University of
British Columbia
Cardiovascular role of iNOS in
diabetes.
Blood pressure, diet,
metabolis syndrome, risk
factors, vascular dysfunction.
20082011
107,170
107,170
I
Pilote, Louise; Karp, McGill University
Igor; Bacon, Simon
L; Chalifour, Lorraine
E.; Cox, Jafna L.;
Dasgupta, Kaberi;
Daskalopoulou,
Styliani-Stella;
Eisenberg, Mark
J.; Engert , James
C.; Ghali, William
A.; Hamet, Pavel;
Humphries, Karin
H.; Khan, Nadia
A.; Lavoie, Kim L.;
Norris, Colleen
M.; Rabi, Doreen
M.; Stark, Ken D.;
Tagalakis, Vicky;
Tremblay, André; Tu,
Jack V.
GENESIS PRAXY: Gender and sex
determinants of cardiovascular
disease from bench to beyond
in premature acute coronary
syndrome.
Cardiovascular disease,
sex differences, premature
acute coronary syndrome,
risk factors, determinants of
health.
20082011
45,747
45,747
II,III,IV
Term
Cumulative
Theme
$ to 2009
66
Keywords
08-09 $
Investigator
Pryzdial, Edward
University of
British Columbia
Coagulation initiated on herpes
virus.
Coagulation, fibrinolysis,
herpes, thrombosis,
biochemistry.
20062009
112,884
338,091
I
Pryzdial, Edward
University of
British Columbia
Effects of plasmin on
prothrombinase.
Coagulation, fibrinolysis, factor
X, plasminogen, factor V.
20072010
118,725
237,450
I
Rodrigues, Brian
University of
High fat induced changes in
cardiac metabolism and its
consequences.
High fat diet, insulin
resistance, heart metabolism,
PPAR, cardiomyopathy.
20072010
80,014
160,028
I
A randomized, double-blind,
multi-center of antiarrhythmic
medications in the treatment
of infants with supraventricular
tachycardia (SAMIS Trial).
Arrhythmia, supraventricular
tachycardia, treatment, clinical
trial, infants.
20062010
110,080
332,920
II,III,IV
Sandor, George; van B.C. Children's
Breemen, Cornelius; Hospital
Potts, James E.
Losartan vs. atenolol in the
treatment of Marfan patients.
Marfan syndrom, aorta, pulse
wave velocity, biophysicial
properties, endothelial
function, drug therapy.
20072009
53,807
121,154
II,III,IV
Steinbrecher, Urs
Vancouver
General Hospital
Activation of macrophage growth
and survival pathways by oxidized
LDL.
20042009
141,658
702,779
I
Tibbits, Glen;
Paetzel, Mark W.
Simon Fraser
University
Regulation of cardiac myofilament
sensitivity to calcium.
Troponin C, design of
calcium sensitizing drugs,
cardiac contractility, familial
hypertrophic cardiomyopathy.
20062009
152,150
456,450
I
Walley, Keith;
Murkin, John M.
St. Paul's Hospital
Genetic determinants of
neurocognitive dysfunction
following cardiopulmonary
bypass.
Cardiopulmonary bypass,
genes, polymorphism,
cognitive dysfunction.
20082011
80,000
80,000
I,II
Wang, Yu Tian
University of
British Columbia
Investigation into the molecular
mechanisms mediating
excitotoxicity - developing novel
post-stroke therapies.
NMDA receptor, excitotoxicity,
stroke, AMPA receptor,
apoptosis.
20062011
121,340
364,020
I
Wellington, Cheryl;
Pritchard, Haydn;
Hirsch Reinshagen,
Veronica U.
Child & Family
Research Institute
Role of lecithin: Cholesterol
acyltransferase (LCAT) in brain
lipoprotein metabolism.
LCAT, brain, lipoprotein,
traumatic brain injury,
apolipoprotein E.
20082011
100,806
100,806
I
Yang, Decheng
St. Paul's Hospital
Specific delivery of antiviral drugs
to target cells using ligandmediated pRNA nanoparticles.
Vector, nanoparticle, gene
targeting, siRNA, ribozyme.
20072010
97,600
195,200
I,II
Zehr, E. Paul
University of
Victoria
Utilization of spinal circuitry and
cutaneous feedback for recovery
of walking after stroke.
Stroke, reflex, feedback,
walking, central patterning,
cutaneous.
20052009
120,000
475,326
I,II
B.C. Children's
Hospital
Keywords
Term
Cumulative
Theme
$ to 2009
British Columbia
Sanatani,
Shubhayan;
Etheridge, Susan
P.; McCrindle, Brian
W.; Potts, James
E.; Stephenson,
Elizabeth A.
Project
08-09 $
II: Clinical
67
Project
Investigator
Bains, Jaideep S.
University of
Calgary
Presynaptic release dynamics at
glutamate synapses: Implications
for controlling the activity of
vasopressin neurons.
Vasopressin, hypothalamus,
electrophysiology, synaptic,
glutamate.
20082011
57,000
57,000
I
Barber, Phillip A.
University of
Calgary
The characterisation of the
neuroinflammatory endothelial
response to ischemia /
reperfunsion by magnetic
resonance molecular imaging
(MRMI).
MRI, stroke contrast agent,
inflammation.
20072010
57,000
114,000
I
Beaulieu, Christian
University of
Alberta
Advanced MRI methods for brain
evaluation in acute stroke.
Magnetic resonance imaging,
acute stroke, diffusion,
perfusion, sodium.
20062009
52,000
156,000
I,II
Belenkie, Israel
University of
Calgary
Direct ventricular interaction
in pulmonary hypertensive
conditions.
Mechanical ventilation,
cardiac function, cardiorespiratiory interaction, heart
failure.
20072010
49,000
98,000
I,II
Berthiaume, Luc G.
University of
Alberta
Role of mitochondrial protein
fatty acylation in the metabolic
syndrome.
Protein fatty acylation,
obesity, type II diabetes,
metabolism, mitochondria.
20082011
57,000
57,000
I
Bonnet , Sébastien
Université Laval
Dehydroepiandrosterone reverses
vascular remodeling diseases.
Vascular remodeling diseases,
apoptosis, K+ channels, PI3K,
NFAT.
20082011
57,000
57,000
I
Braun, Andrew P.
University of
Calgary
Understanding the integrinevoked cellular pathways that
regulate vascular tone.
Vasodilation, integrin
signalling, ca-activated
K(+) channels, nitric oxide
phosphorylation.
20072010
57,000
114,000
I
Brindley, David N.
University of
Alberta
Control of cardiac fatty acid and
glucose metabolism by lipins.
Lipin, phosphatidate
phosphatases, triacylglycerol
synthesis, glucose
metabolism, fatty acid
oxidation.
20082009
14,250
14,250
I
Butcher, Ken S.;
Jeerakathil, Thomas
J.
University of
Alberta
Cerebral perfusion and blood
pressure in intracerebral
hemorrhage: a safety study.
Stroke, intracerebral
hemorrhage, perfusion, blood
pressure, antihypertensives.
20072009
77,000
154,000
II
Campbell, Tavis;
Campbell, Norm
R.C.; Bacon, Simon
L; Ditto, Blaine;
Faris, Peter D.
University of
Calgary
Blood pressure dipping.
Ambulatory blood pressure,
dipping, sleep, ambulatory
impedance monitor.
20072010
52,000
104,000
I,II
Casey, Joseph R.
University of
Alberta
Chloride/bicarbonate exchangers
in cardiac hypertrophy.
Bicarbonate transport,
hypertrophy, ischemia, pH
regulation.
20082011
57,000
57,000
I,II
Childs, Sarah J.
University of
Calgary
Signalling pathways in vascular
integrity.
Angiogenesis, development,
genetics, zebrafish,
hemorrhage.
20082011
57,000
57,000
I
Term
Cumulative
Theme
$ to 2009
68
Keywords
08-09 $
Investigator
Clanachan,
Alexander S.;
Finegan, Barry A.
University of
Alberta
Enhancing post-ischemic recovery
of stressed hearts.
Ischemia-reperfusion,
contractility, glucose
metabolism, oxidative stress,
stress kinase signalling.
20082011
52,000
52,000
I
Colbourne,
Frederick
University of
Alberta
Rodent studies targeting recovery
from intracerebral hemorrhage.
Stroke, intracerebral
hemorrhage, rehabilitation,
recovery, rodent.
20072010
53,000
106,000
I
Cole, William C.;
Plane, Frances
University of
Calgary
Role of endothelial small
conductance Ca2+ activated
K+ channels in delayed cerebral
vasospasm in a rat model of
subarachnoid hemorrhagic stroke.
Cerebral vasospasm, stroke,
endothelium, SKCa channels,
nitric oxide.
20062009
57,000
171,000
I
Davidge, Sandra T.;
Mitchell, Bryan F.
University of
Alberta
Vascular effects of pregnane X
receptor activation.
Vascular, endothelium, nuclear
receptors, cytochrome p450,
nitric oxide synthase.
20072010
49,000
98,000
I, II
Demchuk, Andrew
M.; Green, Theresa
L.; Eliasziw, Michael
University of
Calgary
Evaluation of magnetic
resonance imaging as a potential
surrogate endpoint for future
stroke. Intervention trials when
compared to clinical outcomes in
nondisabling minor stroke and TIA
(VISION-2).
TIA, acute stroke, arterial
occlusion, MRI, prognosis.
20062009
49,000
147,000 I,II,III,IV
Duff, Henry J.
University of
Calgary
Genetic and environmental
calcium interactions modulate the
cellular LQT2 phenotype.
Cellular calcium, ryanodine
receptor, restitution of
repolarization, postextrasystolic potentiation, T
wave alternan.
20062009
49,000
147,000
I
El-Kadi, Ayman O.
University of
Alberta
The role of cytochrome
P450 family 1 enzymes in
the development of cardiac
hypertrophy.
Arachidonic acids, cardiac
hypertrophy, cytochrome
P450, signaling pathways,
oxidative stress.
20062009
49,000
147,000
I
Exner, Derek V.
University of
Calgary
Torsion optimization to reduce
symptoms and improve outcomes
in non-responders (TORSION).
Heart failure,
resynchronization,
remodelling,
echocardiography, torsion.
20082011
77,000
77,000
II
Fedak, Paul W.M.
University of
Calgary
Role of the metalloendopeptidase
pathway in heart failure.
Metalloendopeptidases, cell
transplantation, paracrine
effect, remodelling, heart
function.
20082011
49,000
49,000
I
Frayne, Richard;
Mahallati, Houman
University of
Calgary
Non-contrast enhanced magnetic
resonance angiography.
Magnetic resonance
angiography (MRA), renal and
peripheral arterial disease
(RAD, PAD), vascular imaging,
atherosclerosis.
20082011
77,000
77,000
I,II
French, Robert J.
University of
Calgary
Molecular bases of sodium
channel isoform-specific drug
targeting.
Sodium channels, conotoxins,
channel block, drug
specificity, antiarrhythmic
/ anticonvulsive / local
anaesthetic.
20062009
57,000
171,000
I
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
II: Clinical
69
Project
Investigator
Giles, Wayne R.
University of
Calgary
Electrophysiological and
biophyical mechanisms of
sphingosine-1-phosphate effects
in mammalian myocardium
S-1-P, EDGE receptors,
ion channels, fibroblasts,
myocytes.
20072010
57,000
114,000
I,II
Gillis, Anne M.
University of
Calgary
Effects of statins on ventricular
hypertrophy, ventricular
electrical remodeling and risk
of arrhythmogenesis in animal
models of left ventricular
hypertrophy.
Hypertrophy, statins,
electrophysiology,
arrhythmogenesis, sudden
death.
20072010
52,000
104,000
I
Hill, Michael D.
University of
Calgary
Tissue window in stroke
thrombolysis -2.
Stroke thrombolysis, brain
imaging, clinical trial.
20062009
57,000
171,000
II,IV
Jacobs-Kaufman,
Susan E.
University of
Alberta
Long-term effect of pregnancy
on neural control of the
cardiovascular system.
Pregnancy, parity,
sympathetic.
20062009
49,000
147,000
I
Jahroudi, Nadia
University of
Alberta
Mechanism of endothelial specific
gene regulation.
Endothelial cells, Von
Willebrand factor,
transcription factor, transgenic
mice, promoter.
20082010
57,000
57,000
I
Jhamandas, Jack H.
University of
Alberta
Role of RFamide peptides in CNS
cardiovascular regulation.
Neuropeptide FF,
prolactin- releasing peptide,
hypothalamus, paraventricular
nucleus, patch clamp,
immunohistochemistry.
20072010
57,000
114,000
I
Kargacin, Gary J.
University of
Calgary
Regulation of compensatory ion
channels in cardiac and smooth
muscle sarcoplasmic reticulum.
Sarcoplasmic reticulum,
compensatory charge
movement, potassium
channels, chloride channels.
20062009
52,000
156,000
I
Kargacin, Margaret
E.
University of
Calgary
Phospholamban and regulation of
SR calcium.
Calcium, cardiac,
sarcoplasmic reticulum,
Ca-ATPase, phospholamban.
20062009
49,000
147,000
I
Khan, Nadia A.;
St. Paul’s
Hill, Michael D.;
Hospital
Hsiung, Ging-Yuek
R.; Humphries,
Karin H.; Kapral,
Moira K.; McAlister,
Finlay A.; Palepu,
Anita; Pilote, Louise;
Quan, Hude
stroke prognosis and quality of
care.
Ethnicity, stroke,
administrative data, sex,
mortality.
20082010
53,000
53,000
II,III
Krukoff, Teresa L.
University of
Alberta
Adrenomedullin and regulation of
autonomic function.
Adrenomedullin,
paraventricular nucleus,
autonomic, brain, blood
pressure, baroreflex, nitric
oxide, calcium.
20062009
52,000
156,000
I,II
Kubes, Paul
University of
Calgary
Role of LSP-1 as a gatekeeper
of the blood brain barrier to
neutrophils.
Adhesion, inflammation,
microvasculatures, selectins,
integrin.
20062009
52,000
156,000
I
Term
Cumulative
Theme
$ to 2009
70
Keywords
08-09 $
Investigator
Lehner, Richard
University of
Alberta
Triacylglycerol metabolism.
Triacylglycerol, cholesterol,
AADA, lipoproteins,
atherosclerosis.
20072010
52,000
104,000
I
Lopaschuk, Gary D.
University of
Alberta
Cardiac lipotoxicity in obesity and
diabetes.
Obesity, energy metabolism,
fatty acids, cardiotoxicity.
20062009
57,000
171,000
I
Loutzenhiser,
University of
Calgary
Altered renal afferent arteriolar
myogenic response in diabetes.
Diabetes, microvasculature,
kidney, myogenic,
hypertension.
20072010
52,000
104,000
I
Lytton, Jonathan
University of
Calgary
Molecular analysis of NCX1
regulation.
Na/Ca exchanger, calcium
signaling, structure-function,
molecular biology, heart
disease.
20082011
57,000
57,000
I
Michelakis,
Evangelos D.
University of
Alberta
Phosphodiesterase type 5
inhibition: a novel means for
enhancing right ventricular
function.
Inotrophy,
phosphodiesterases, right
ventricle, cardiac hypertrophy,
20072010
46,000
92,000
I, II
Morrish, Donald W.
University of
Alberta
Endothelial progenitor cells in
preganacy and preeclampsia.
Preeclampsia, pregnancy,
endothelial progenitor cells.
20062009
49,000
147,000
I, II
Murray, Allan G.
University of
Alberta
Remodelling of endothelial
cells-matrix anchors.
Endothelium, vascular,
cytoskeleton, cell migration.
20062009
49,000
147,000
I, II
Nygren, Anders;
Vigmond, Edward J.
University of
Calgary
Computational and experimental
investigation of the effects
of spatial heterogeneity of
refractoriness on inducibility and
maintenance of atrial fibrillation in
the mouse atria.
Atrial fibrillation, mouse
atrium, computer models,
optical mapping, dispersion
of refractoriness.
20072010
49,000
98,000
I
Oudit, Gavin Y.
University of
Alberta
Role of PI3K in pathological
biomechanical stress and heart
failure.
Signaling, hypertrophy,
cardiovascular physiology,
heart failure, extracellular
matrix.
20082011
49,000
49,000
I
Patel, Kamala D.
University of
Calgary
Regulation and function of
macrophage-derived eotaxin-3
(CCL26).
Atherosclerosis, inflammation,
chemokine, signaling,
monocyte/macrophage.
20072010
52,000
104,000
I
Paterson, David Ian; University of
Friedrich, Matthias
Alberta
G.; Pearson, Glen J.;
Thompson, Richard
B.
Cardiac magnetic resonance
imaging for the diagnosis of acute
heart transplant rejection.
Cardiac MRI, cardiac
transplantation, allograft
rejection.
20082010
49,000
49,000
I,II
Pavlov, Evgeny
Mitochondrial polyphosphate
of higher eukaryotes: its
metabolisms, biochemistry and
role in regulation of cell death.
Polyphosphate, mitochondria,
necrosis, apoptosis,
permeability transition.
20072010
49,000
98,000
I
Rodger D.
University of
Calgary
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
II: Clinical
71
Investigator
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
Pilote, Louise; Karp, McGill University
Igor; Bacon, Simon
L; Chalifour, Lorraine
E.; Cox, Jafna L.;
Dasgupta, Kaberi;
Daskalopoulou,
Styliani-Stella;
Eisenberg, Mark
J.; Engert , James
C.; Ghali, William
A.; Hamet, Pavel;
Humphries, Karin
H.; Khan, Nadia
A.; Lavoie, Kim L.;
Norris, Colleen
M.; Rabi, Doreen
M.; Stark, Ken D.;
Tagalakis, Vicky;
Tremblay, André; Tu,
Jack V.
Genesis praxy: Gender and sex
syndrome.
gender and sex differences,
premature acute coronary
syndrome, risk factors,
determinants of health.
20082011
48,083
48,083
II,III,IV
Plane, Frances
University of
Alberta
Endothelial-smooth muscle cell
communication: Key role of KCa.
Enothelial dysfunction, nitric
oxide, potassium channel,
vasodilation, smooth muscle.
20082011
49,000
49,000
I
Poulin, Marc J;
Hanly, Patrick J.V.
University of
Calgary
Regulation of cerebral blood flow
in obstructive sleep apnea: role of
nitric oxide.
Cerebral blood flow, hypoxia
and hypercapnia, obstructive
sleep apnea, nitric oxide,
doppler ultrasound.
20062009
65,554
196,662 I,II,III,IV
Proctor, Spencer D.
University of
Alberta
Mechanisms of trapping
apoB48-remnant lipoproteins in
arterial tissue by proteoglycans
during atherogenesis and insulinresistance.
Atherogenesis, chylomicrons,
proteoglycans, insulinresistance, adiponectin.
20062009
49,000
147,000
I
Rabi, Doreen M.;
University of
Ghali, William
Calgary
A.; Shrive, Fiona
M.; Faris, Peter
D.; Pilote, Louise;
Daskalopoulou,
Styliani-Stella;
Vallée, Michel; Karp,
Igor; Humphries,
Karin H.; Khan,
Nadia A.
Exploring sex differences in
the efficacy of cardioprotective
medications: a series of metaanalyses.
Sex differences,
cardiovascular disease, drug
efficacy, meta-analyses.
20082010
52,000
52,000
II, IV
Schulz, Richard;
Daniel, Edwin E.
Caveolin regulation of matrix
metalloproteinases in the heart.
Caveolin, matrix
metalloproteinase, heart.
20072010
57,000
114,000
I
University of
Alberta
72
Investigator
Severson, David L.
University of
Calgary
Mechanisms of diabetic
cardiomyopathy - cardiac
efficiency in hearts from diabetic
mice.
Cardiac function, diabetes,
diabetic cardiomyopathy.
20062009
49,000
147,000
I
Sheldon, Robert S.
University of
Calgary
Statin induced regression of
cardiomyopathy trial (SIRCAT).
Hypertrophic cardiomyopathy,
statins, cardiac MRI, clinical
study, arrhythmia.
20062009
89,260
267,780
I,II
Shimoni, Yakhin;
Nygren, Anders
University of
Calgary
Regulation of cardiac impulses
propagation in the diabetic heart.
Diabetes, impulse
propagation, arrhythmia, gap
junction, gender.
20082011
52,000
52,000
I,II
Sykes, Brian D.
University of
Alberta
Structure of cardiac troponin in
complex with cardiotonic drugs.
Structure, troponin C,
troponin I, calcium binding,
cardiotonic drugs, NMR.
20082011
57,000
57,000
I
ter Keurs, Henk
E.D.J.
University of
Calgary
The velocity of cardiac muscle
shortening.
Cardiac muscle, congestive
heart failure, excitation
contraction coupling, high
speed confocal micro,
ischemic heart disease,
sarcomere mechanics.
20062009
57,000
171,000
I
Thebaud, Bernard
University of
Alberta
Experimental therapies to prevent
pulmonary hypertension and
promote lung vascular growth in
congenital diaphragmatic hernia.
Pulmonary hypertension of
the newborn, angiogenesis,
calcium sensitization, lung
growth, vasoreactivity.
20072010
52,000
104,000
I
Tonelli, Marcello A.;
Culleton, Bruce F.;
Jindal, Kailash K.
University of
Alberta
Relation between residence
location, care quality and
cardiovascular events in people
with diabetes mellitus and kidney
disease.
Diabetes, myocardial
infarction, stroke, proteinuria,
kidney disease.
20072010
49,000
98,000
III,IV
Tse, Amy Me-War
University of
Alberta
Regulation of chemotransduction
in carotid bodies.
Respiration, neuron-glial
interactions, oxygen sensing,
secretion, calcium.
20062009
52,000
156,000
I
Tsuyuki, Ross T.;
Koshman, Sheri L.;
McAlister, Finlay A.;
Ezekowitz, Justin A.;
Shibata, Marcelo;
Rowe, Brian H.
University of
Alberta
Heart failure evaluation - acute
referral team trial (HEARTT).
Heart failure, multidisiplinary,
rapid referral, short-term
follow-up, hospitalizations.
20072010
-
75,000
II,III
Vance, Jean Eaton
University of
Alberta
Phosophlipid synthesis,
lipoprotein secretion, and
Phosphatidylcholine,
phosphatidylserine, VLDL,
transcription, heart.
20072010
49,000
98,000
I
Vigmond, Edward
J.; Vinet, Alain
University of
Calgary
Localization of neural
modulation of atrial excitation
and repolarization and the
arrhythmogenic consequences.
Electrograms, atria, cardiac
autonomic nervous system,
arrhythmogenesis, computer
modeling.
20062009
23,000
110,500
I
Walsh, Michael P.
University of
Calgary
Vascular smooth muscle S100A11
calcium-binding protein.
Vascular smooth muscle, s100
calcium-binding proteins,
contractility, membranecytoskeleton interaction,
annexins.
20072010
52,000
104,000
I
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
II: Clinical
73
Project
Keywords
Term
08-09 $
Investigator
Cumulative
Theme
Welsh, Donald G.
University of
Calgary
Electrical communication in the
resistance vasculature.
Peripheral circulation,
computer modeling,
electrophysiology, vascular
smooth muscle, cell-to-cell
communication.
20072010
57,000
114,000
I
Yager, Jerome Y.
University of
Alberta
Averting perinatal brain damage
using a natural health product: a
novel approach to the prevention
of white matter injury in premature
infants.
Neonatal, hypoxiaischemia, white-matter
injury, neuroprotection,
complementary medicine and
natural health products.
20082011
52,000
52,000
I
Young, Howard S.
University of
Alberta
Molecular insights into heart
disease - structure, function and
regulation of SERCA2a.
Heart disease, muscle,
membrane, regulation,
sarcoplasmic reticulum.
20062009
57,000
171,000
I
Zamponi, Gerald W.
University of
Calgary
Trafficking of L-type calcium
channels.
Calcium channel, L-type,
targeting, patch clamp,
auxiliary subunits.
20082011
57,000
57,000
I
Zheng, Xi-Long
University of
Calgary
Effects of uridine adenosine
tetraphosphate on smooth muscle
cells and atherosclerosis.
Endothelium-derived
constriction factor, cell
cycle, uridine adenosine,
tetraphosphate, smooth
muscle cells, atherosclerosis.
20072010
49,000
98,000
I
$ to 2009
Saskatchewan
Project
Investigator
Cayabyab,
Francisco S.
University of
Saskatchewan
Adenosine A1 receptor and
AMPA receptor interactions
at a postsynaptic locus: role
in hippocampal neurotoxicity
during ischemia.
Adenosine and glutamate
receptor interactions, synaptic
depression, neurotoxicity,
brain slice electrophysiology,
interfering peptide strategies.
20082011
50,000
50,000
I
Fisher, Thomas E.
University of
Saskatchewan
An osmosensitive K+ current
that regulates vasopressin
release.
Vasopressin, K+ current,
supraoptic nucleus,
osmosensitivity, patch clamp.
20082011
40,000
40,000
I
Hiebert, Linda M.
University of
Saskatchewan
Oral heparins.
Heparins, oral thrombosis,
absortion, endothelium.
20082011
50,000
50,000
I
Meng, Qing H.;
Adeli, Khosrow
University of
Saskatchewan
Methylglyoxal (MG), a key
mediator of diet-induced insulin
resistance, dyslipidemia, and
atherosclerosis.
Methylglyoxal (MG),
inflammation, oxidative
stress, insulin resistance,
atherosclerosis.
20082011
50,000
50,000
I
Ndisang, Joseph
Fomusi
University of
Saskatchewan
Interaction of the heme
oxygenase pathway with reninangiotensin system in diabetes.
Diabetes, hypertension,
angiotensin, heme oxygenase
inducers, carbon monoxide.
20062009
40,000
138,500 I,II,III,IV
Paterson, Phyllis G.
University of
Saskatchewan
Nutritional factors as
determinants of brain injury in
stroke.
Global ischemia, nutrition,
protein-energy malnutrition,
hypothermia, caloric restriction.
20072010
55,000
110,000
I
Prasad, Kailash
University of
Saskatchewan
Atherosclerosis, endothelial cell
Flax lignan complex in the
function, lipids, oxygen radicals,
progression and regression
regression.
of hypercholesterolemic
atherosclerosis and mechanisms.
20062009
40,000
138,500
I
Term
Cumulative
Theme
$ to 2009
74
Keywords
08-09 $
Project
Keywords
Term
08-09 $
Investigator
Cumulative
Theme
Sharma, Rajendra
K.
University of
Saskatchewan
Calmodulin regulated systems
in heart.
Ca2+, calmodulin,
calmodulin-binding proteins,
Ca2+ - activated proteases,
phosphodiesterases, cardiac
metabolism.
20062009
60,000
187,000
I
Walz, Wolfgang
University of
Saskatchewan
Inflammation in experimental
lacunar infarction.
Inflammation, lacunar infarction,
astrocytes, microglia, neuronal
degeneration.
20082011
40,000
40,000
I
$ to 2009
Manitoba
Investigator
Anderson, Hope
D.I.
St. Boniface
General Hospital
Research Centre
Endocannabinoids and the
regulation of cardiac hypertrophy.
Endocannabinoid, cannabinoid
receptors, anandamide, cardiac
myocyte, hypertrophy.
20082010
46,000
46,000
I
Bhullar, Rajinder Pal
University of
Manitoba
Calmodulin interaction with
Racl-Cdc42 and platelet function.
Racl, Cdc42, GTPases,
calmodulin, platelet morphology.
20072009
42,000
84,000
I
Del Bigio, Marc R.
University of
Manitoba
Periventricular hemorrhage in
immature brain.
Brain hemorrage, premature
birth, cerebral palsy, animal
models, imaging.
20062009
39,000
117,000
I
Dhalla, Naranjan S.
St. Boniface
General Hospital
Research Centre
Studies on the biochemical basis
of heart function: adrenergic
mechanisms in failing hearts.
Congestive heart failure,
beta-adrenoceptors, G-protiens,
adenylyl cyclase, signal
transduction.
20072010
42,000
84,000
I
Dixon, Ian M.C.
St. Boniface
General Hospital
Research Centre
Inhibition of the Smad signal in
post-MI heart failure.
Myocardial infarction, gene
expression, cardiac fibrosis,
collegen, hypertrophy and heart
failure, Smad.
20072010
60,000
120,000
I
Hatch, Grant M.
University of
Manitoba
Regulation of cardiolipin
biosynthesis in the heart.
Heart, phospholipid, cardiolipin,
heart failure, lipid synthesis.
20072010
50,000
100,000
I
Jassal, Davinder S.
St. Boniface
General Hospital
The interaction of hyperlipidemia
Chronic pressure overload,
and NOS3 on ventricular
nitric oxide, obesity, ventricular
remodeling after pressure-induced remodeling, hyperlipidemia.
overload.
20072009
46,000
92,000
I
Kardami, Elissavet
St. Boniface
General Hospital
Research Centre
Connexin-43 and cardiac myocyte
proliferation.
Connexin-43, DNA sysnthesis,
signal transduction, TGF-beta,
heart cells.
20082011
48,000
48,000
I
Kirshenbaum, Lorrie
A.
St. Boniface
General Hospital
Research Centre
Mechanisms of p53 mediated
apoptosis in heart.
Apoptosis, p53, heart failure,
ventricular myocytes, cell culture.
20072010
43,000
86,000
I
McNicol, Archibald
University of
Manitoba
Oral pathogens, MAP kinases and
platelets.
Platelets, periopathogens,
signaling, inflammation, secretion.
20082011
45,000
45,000
I
Mesaeli, Nasrin
St. Boniface
General Hospital
Research Centre
Regulation of cell proliferation by
calreticulin.
Vascular function, calcium
regulation, gene regulation.
20062009
38,000
114,000
I
Miller, Donald W.
University of
Manitoba
Sphingosine 1-phosphate and
cerebral microvessel responses to
hypoxia.
Blood-brain barrier, hypoxia,
cerebral microvasculature,
sphignosine 1-phosphate.
20082010
45,000
45,000
I
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
II: Clinical
75
Investigator
Project
Keywords
08-09 $
Term
Cumulative
Theme
$ to 2009
Netticadan, Thomas St. Boniface
J.
General Hospital
Research Centre
The potential of resveratrol as an
agent in prevention of cardiac
hypertrophy.
Pressure overload, volume
overload, cardiac hypertrophy,
heart failure.
20072010
41,000
82,000
I
O, Karmin
Effect of folic acid on hyperhomocysteinemia.
Hyperhomocysteinemia, atherosclerosis, folic acid, chemokines,
oxidative stress.
20062009
36,000
108,000
I
Parkinson, Fiona E.; University of
Albensi, Benedict C; Manitoba
Peeling, James
Stroke injury in genetic mouse
models.
Adenosine, purinergic signalling,
focal ischemia, hippocampal
slices.
20082010
45,000
45,000
I
Pierce, Grant N.
St. Boniface
General Hospital
Research Centre
Involvement of Na/Ca exchange
in contraction under control
conditions and during ischemia/
reperfusion injury.
Ischemia, Na+/Ca2+ exchange,
excitation-contraction coupling,
RNA.
20072010
42,500
85,000
I
Shen, Garry
University of
Manitoba
Impact of oxidized low density
lipoproteins on mitochondrial
activity and oxidative stress in
vascular endothelial cells.
Mitochondria, reactive oxygen
species, oxidized LDL, vascular
endothelial cells, coenzyme Q10.
20082010
42,000
42,000
I
Singal, Pawan K.
St. Boniface
General Hospital
Research Centre
Molecular changes leading to
the activation of MAP kinases
and apoptosis in cardiomyocytes
exposed to doxorubicin.
Cardiomyopathy, heart failure,
MAP kinases, apoptosis, oxidative
stress.
20082010
43,000
43,000
I
Siow, Yaw L. Chris
University of
Manitoba
Regulation by stress-associated
scaffold protein in ischemia/
reperfusion.
SAP kinase, scaffold, regulation,
ischemia/reperfusion, inhibitor.
20062009
32,000
96,000
I
Tappia, Paramjit S.
St. Boniface
General Hospital
Research Centre
Role of phospholipase C isozymes
in hypertrophy of the adult heart.
Adult cardiomyocytes,
hypertrophy, phospholiapase C
isozymes, signal transduction.
20072009
40,000
80,000
I
Project
Keywords
Term
Investigator
Adams, Michael A.
Queen's University
Antihypertensive treatment
strategies in the management
of sexual dysfunction.
Sexual dysfuntion, aging,
vascular structure and
function, pharmacotherapy,
hypertension, endothelial
function.
20082011
95,533
95,533
I
Adeli, Khosrow
Hospital for Sick
Children
apolipoprotein B degradation.
Apolipoprotein B,
degradation, hepatocytes,
proteasome, ER60.
20052009
117,860
457,758
I
Adeli, Khosrow
Hospital for Sick
Children
Molecular mechanism of
hepatic VLDL overproduction
in insulin resistance.
Dyslipidemia, insulin
resistence, VLDL,
apolipoprotein B, hamster.
20072012
138,235
274,152
I
St. Boniface
General Hospital
Research Centre
Ontario
Cumulative Theme
$ to 2009
76
08-09 $
Keywords
08-09 $
Cumulative Theme
Investigator
Anand, Sonia S.;
Bosch, Jacqueline
J.; Gaudet, Daniel;
Gerstein, Hertzel
C.; Keavney,
Bernard D.;
Merchant, Anwar
T.; Perusse, Louis;
Pogue, Janice M.;
Yusuf, Salim
McMaster
University
EpiDREAM - A prospective
cohort study to determine
environment and genetic
determinants of metabolic
syndrome related factors.
Metabolic syndrome, cohort
study, gene-environment
interactions.
20062009
161,495
475,656
IV
Anand, Sonia S.;
Engert, James C.;
Cordell, Heather
J.; Keavney, Benard
D.; Xie, Changchun
McMaster
University
Understanding genetic
associations with myocardial
infarction in multiethnic
populations.
Genetics, myocardial
infarction, ethnic groups,
population health.
20082010
46,747
46,747
IV
Andrew, R. David
Queen's University
Imaging and preventing
early stroke damage in intact
mammalian neurons.
2-photon, anoxin
depolarization, dendrite,
swelling, imaging.
20062009
74,328
220,406
I,II
Athale, Uma H.;
Moghrabi, Albert;
Silverman, Lewis
B.; Chan, Anthony
K.C.; Thabane,
Lehana
McMaster
University
Evaluation for inherited and
acquired prothrombotic
defects predisposing
to symptomatic
thromboembolism in children
with acute lymphoblastic
leukemia.
Acute lymphoblastic
leukemia, thromboembolism,
prothromobotic disorder,
chemotherapy, children.
20072009
40,351
85,702
II
Austin, Richard C.
McMaster
University
Inhibition of tissue factor
procoagulant activity by GRP78
and its role in thrombosis.
GRP78, tissue factor,
thrombin generation,
endoplasmic reticulum stress,
thromboembolic disease.
20072010
87,471
172,462
I
Austin, Richard C.
McMaster
University
Role of the sterol regulatory
element-binding proteins
in foam cell formation and
atherogenesis.
Endoplasmic reticulum stress,
unfolded protein response,
atherosclerosis, macrophage
foam cells, SREBP.
20072010
94,877
188,714
I
Austin, Richard C.
McMaster
University
Contributions of the unfolded
protein response pathway to
adipogenesis and obesity.
Adipogenesis, obesity,
endoplasmic reticulum stress,
metabolic syndrome.
20082011
79,234
79,234
I
Backx, Peter H.
University Health
Network
Transcriptional regulation of
cardiac transient outward K+
currents and function in heart.
Heart disease,
gene transcription,
electrophysiology,
arrhythmias, hypertrophy.
20082013
149,714
149,714
I,II
Bartha, Robert;
Lee, Ting-Yim;
Xenocostas,
Anargyros
Robarts Research
Institute
New metabolic imaging
approaches to assess brain
tissue viability.
1H MRS, high resolution
metabolic MR imaging, acute
cerebral ischemia, metabolite
quantification, molecular
penumbra.
20062009
85,645
251,519
I
Project
Term
$ to 2009
II: Clinical
77
Project
08-09 $
Cumulative Theme
Investigator
Beanlands, Rob
S. B.; Haddad,
Haissam; Leech,
Judith A.; Burwash,
Ian G.; Mielniczuk,
Lisa M.; Floras,
John S.; DaSilva,
Jean N.; de Kemp,
Robert A.
University of
Ottawa Heart
Institute
Effects of continuous positive
airway pressure therapy on
myocardial energetics and
sympathetic nerve function in
patients with heart failure and
obstructive sleep apnea.
Heart failure, sleep apnea,
oxidative metabolism, cardiac
efficiency, sympathetic nerve
function, PET.
20082010
125,159
125,159
II
Belik, Jaques;
Letarte, Michelle
V.; Jerkic, Mirjana;
Toporsian, Mourad
Hospital for Sick
Children
ENOS uncoupling and role
of bone morphogenetic
protein-9 in the regulation of
pulmonary vascular tone during
development and following
Pulmonary vascular,
development, eNOS, nitric
oxide, bone morphogenetic
protein.
20072009
87,725
174,631
I
Benazon, Nili R.;
Arthur, Heather M;
Blanchard, Chris
M.; Kodis, Jennifer
A.; Toner, Brenda B.
Centre for
Addiction and
Mental Health
Correlates of women's
compliance with exercise
prescriptions during and
following cardiac rehabilitation.
Cardiology, health-related
behaviour, exercise, women,
psychosocial.
20082010
109,868
109,868
II
Bendeck, Michelle
P.
University of
Toronto
Cadherins and regulation of
smooth muscle cell function.
Cadherin, polarity, migration,
vasular smooth muscle,
restenosis.
20072012
125,957
255,010
I
Bendeck, Michelle
P.
University of
Toronto
Discoidin domain receptors
(DDR1) in atherosclerosis.
Vascular biology,
atherosclerosis, extracellular
matrix, calcification,
inflammation.
20072009
84,860
169,720
I
Birnie, David H.;
Ruddy, Terrence
D.; Sapp, John L.;
Wells, George A.
University of
Ottawa Heart
Institute
Long-term effects of cardiac
resynchronization therapy on
LV remodeling and ventricular
arrhythmia: the reverse
remodeling study.
Cardia resynchronization
therapy, remodeling,
ventricle, ventricular
arrhytmia, long-term.
20082010
20,100
20,100
II
Boffa, Michael B.
Queen's University
The TAFI pathway in
thrombolysis: regulation of
TAFI activation and role of the
platelet pool of TAFI.
TAFI, fibrinolysis,
thrombolysis, platelets,
transgenic mice.
20062009
90,969
289,610
I
Bolz, SteffenSebastian
University of
Toronto
Mechanisms that regulate
the pressure-dependent
activation of the sphingosine-1phosphate signalling pathway
in resistance arteries.
Resistance arteries, vascular
smooth muscle, sphingosine
kinase, transfection, calcium
independent constriction.
20072009
70,190
140,380
I
Bonen, Arend
University of
Guelph
Regulation of fatty acid
transport in the heart.
Fatty acid transporters,
transport, metabolism, heart,
cardiac myocytes.
20062011
97,646
290,947
I
Boughner, Derek
R.; Rogers, Kem A.;
Lacefield, James C.
University of
Western Ontario
A tissue engineering approach
to bioprosthetic heart valve
design.
Tissue engineering, aortic
valve, biomechanics,
ultrasound imaging, valvular
interstitial cells.
20062009
95,398
307,457
I
$ to 2009
78
Keywords
Term
Project
Keywords
Term
University of
Western Ontario
Early image-based diagnosis of
aortic valve sclerosis in a rabbit
model.
Aortic sclerosis,
hyperlipidemia, rabbit model,
magnetic resonance imaging,
ultrasound, computed
tomography.
20082010
80,000
80,000
I,II
Bradley, Timothy J.;
Silverman, Earl D.;
Schneider, Rayfel;
Feldman, Brian M.;
Beyene, Joseph
Hospital for Sick
Children
Inflammation and
atherosclerosis in pediatric
rheumatic diseases.
Pediatrics, chronic
inflammation, atherosclerosis,
traditional risk factors,
surrogate markers of
atherosclerosis.
20072009
66,045
125,488
II,IV
Caldarone,
Christopher A.;
Redington, Andrew
N.
Hospital for Sick
Children
Apoptosis-related
mitochondrial dysfunction in
the neonate after cardioplegic
arrest.
Cardioplegia, myocardium,
mitochondria, apoptosis,
neonate.
20072009
117,116
233,655
I,II
Cattral, Mark S.
Toronto General
Hospital
Role of immediate dendritic
cell precursors in allograft
rejection and tolerance.
Transplantation tolerance,
dendritic cells, ontogeny,
rejection, migration.
20082011
76,694
76,694
I
Cepinskas,
Gediminas
Lawson Health
Research Institute
Cerebrovascular endothelial
cell dysfunction in sepsis: role
of astrocytes.
Inflammation/sepsis,
microvascular endothelium,
astrocytes, cell signaling,
leukocytes.
20072009
82,747
164,630
I
Chakrabarti,
Subrata
University of
Western Ontario
Vasoactive and cardioactive
factors in diabetic heart
disease.
Cardiomyopathy, diabetes,
hypertrophy, gene
transcription, PARP.
20082010
74,400
74,400
I
Chan, Anthony K.C.
McMaster
University
Carbohydrate variation effects
in the protein C pathway
during development.
Children, thromboemolism,
(anti) coagulation, protein C,
glycosylation.
20082011
76,239
76,239
I
Chan, Anthony K.C.
McMaster
University
Surface mechanisms of
anticoagulant ATH complex.
Antithrombin, heparin,
anticoagulant, endothelium,
thrombosis.
20072011
86,139
170,589
I
Chauhan, Vijay S.
University Health
Network
Characterizing ventricular
repolarization alternans in
human cardiomyopathy.
Repolarization,
sudden cardiac death,
cardiomyopathy, ventricle,
human.
20072010
84,004
168,008
I,II
Chen, Hsiao-Huei
Ottawa Health
Research Institute
Mechanisms to reduce injury
and improve recovery from
stroke.
Transcription, stroke,
chromatin, CREB, PPAR
gamma, cerabral ischemia,
neuron survival.
20082011
101,442
101,442
I
Chidiac, Peter
University of
Western Ontario
Role of RGS2 in cardiovascular
and metabolic function.
RGS2 (regulator of G protein
signaling protein 2), G
protein, G protein coupled
receptor, cardiomyocyte,
adipocyte.
20082010
79,150
79,150
I
Investigator
Boughner, Derek
R.; Rogers, Kem A.;
Drangova, Maria;
Rutt, Brian K.;
Lacefield, James C.
08-09 $
Cumulative Theme
$ to 2009
II: Clinical
79
Project
Keywords
Term
University of
Western Ontario
Leptin links obstructive
sleep apnea, obesity and
hypertension.
Obesity, hypertension,
obstructive sleep apnea,
leptin, brainstem,
chemoreceptor reflex,
baroreceptor reflex.
20082011
111,275
111,275
I
Coles, John G.;
Hannigan, Gregory
E.
Hospital for Sick
Children
Defective stem cell signaling in
tetralogy of fallot (FT).
Cardiac stem cells, integrinlinked kinase, cardiac failure,
signal transduction, tetralogy
of fallot.
20082010
79,017
79,017
I
Connelly, Philip W.;
Ng, Dominic S.
St. Michael's
Hospital
Studies of the lactonase
activity of paraoxonase 1 - an
HDL associated enzyme of
relevance to cardiovascular
disease.
Paraoxonase, lactones,
cardiovascular disease, HDL.
20082011
80,000
80,000
I,II
Copeland, John W.
University of
Ottawa
Role of formin proteins in shear
stress-induced cytoskeletal
remodeling in endothelial cells.
Actin cytoskeleton, shear
stress, atherosclerosis, formin,
microtubules.
20082013
103,950
103,950
I
Cote, Graham P.
Queen's University
Formation and function of
invadopodia in vascular
smooth muscle cells.
Smooth muscle, signal
transduction, cell motility,
actin cytoskelton, myosin.
20072012
90,618
179,537
I
Cregan, Sean P.
University of
Western Ontario
Mechanisms of P53 induced
neuronal apoptosis.
Stroke, p53, apoptosis,
oxidative damage, neuronal
injury.
20082011
78,553
78,553
I
Crowther, Mark A.;
Cook, Deborah J.;
Guyatt, Gordon
H.; Warkentin,
Theodore E.
McMaster
University
Evaluating the incidence and
clinical importance of heparin
induced thrombocytopenia in
the critically ill.
Clinical prediction
rule, heparin induced
thrombocytopenia, clinical
trial, thrombosis, critical care.
20072010
65,006
93,178
II,III
Cybulsky, Myron I.
University Health
Network
Arterial responses to
hemodynamic stresses.
Endothelium, shear stress,
cytoskeleton, cell migration,
cell polarity.
20072010
91,308
180,826
I
Cybulsky, Myron I.
University Health
Network
Monocyte recruitment in
atherosclerosis.
Atherosclerosis, monocytes,
recruitment, subpopulations,
chemokine receptors.
20072010
116,845
232,405
I
Cybulsky, Myron I.
University Health
Network
Regional differences in
the arterial intima that
predispose the artery wall to
atherogenesis.
Endothelium, dendritic cells,
Egr-1, gene expression,
atherosclerosis.
20072009
104,659
207,265
I
DaSilva, Jean N.;
Beanlands, Rob
S.B.; de Kemp,
Robert A.
University of
Ottawa Heart
Institute
Altered noradrenergic
signaling transduction in
the development of cardiac
dysfunction in Diabetes: role of
glycemic therapy.
Noradrenaline,
hyperglycemia, positron
emission tomography, type
2 diabetes, cardiovascular
diseases.
20082010
78,481
78,481
I
Investigator
Ciriello, John
Cumulative Theme
$ to 2009
80
08-09 $
Project
Keywords
Term
Expression and characterization
of human cardiac actin mutants
linked to hypertrophic and
dilated cardiomyopathies.
Cardiac actin mutations,
hypertrophic and dilated
cardiomyopathy, baculovirus
protein expressions, actin
reconstitution assays, ectopic
expression.
20082011
78,555
78,555
I
Devereaux, Philip
McMaster
J.; Guyatt, Gordon
University
H.; Cook, Deborah
J.; Haynes, R.
Brian; Paul, James
E.; Yusuf, Salim;
Walter, Stephen D.;
Crowther, Mark A.;
Lonn, Eva M.; Lim,
Wendy; O'Donnell,
Martin; Thabane,
Lehana; HeelsAnsdell, Diane M.;
Armstrong, David;
McQueen, Matthew
J.; Soth, Mark;
De Beer, Justin;
O'Bryne, Paul M.;
Worster, Andrew S.;
Patel, Mohammed
Ameen; Bhandari,
Mohit; Buckley,
David N.; Salehian,
Omid; Meade,
Maureen O.
Vascular events in noncardiac
surgery patients cohort
(VISION) study.
Perioperative vascular risk,
clinically silent myocardial
infarction, noncardiac surgery,
cohort study.
20072009
95,242
188,617
II,IV
Dick, Alexander J.;
Courtman, David
W.; Cunningham,
Charles H.; LeongPoi, Howard M.;
Parker, Thomas G.;
Stewart, Duncan J.
Sunnybrook
Health Sciences
Centre
Endothelial progenitor cell
modification to improve left
ventricular function post
myocardial infarction.
Cell therapy, magnetic
resonance imaging.
20082011
76,877
76,877
I
Drangova, Maria;
Feng, Qingping
Robarts Research
Institute
Dynamic micro-CT for
pre-clinical cardiac imaging.
Three-dimensional micro
computed tomography,
murine cardiac imaging,
myocardial remodeling, heart
failure, cardiac function.
20082011
113,071
113,071
I
D'Souza, Sudhir
J.A.; Dagnino, Lina
University of
Western Ontario
Integrin-linked kinase and
ELMO in endothelial migration
and phagocytosis.
Cells, migration, integrins,
signalling, survival.
20072009
67,744
134,159
I
Dumont, Daniel J.
Sunnybrook
Health Sciences
Centre
Molecular studies examining
the role of lymphangiogenic
signalling in heart disease.
Tie2, lymphangiogenesis,
proteomics, transgenic,
signalling.
20072010
84,900
169,800
I
Investigator
Dawson, John F.
University of
Guelph
08-09 $
Cumulative Theme
$ to 2009
II: Clinical
81
Project
Keywords
Term
University of
Toronto
Mechanistic investigation of
microRNA-mediated regulation
of dilated cardiomyopathy
(DCM).
Cardiac disease, microRNA,
proteomics, bioinformatics,
cardiomyopathy, shRNA.
20082011
96,378
96,378
I,II
Epand, Richard M.
McMaster
University
Development of potent
antiatherogenic peptides.
Anti-inflammatory, apo
A-I mimetic peptides,
paroxonase, HDL, modified
lipoproteins.
20072010
79,250
158,500
I
Eubanks, James H.
University Health
Network
Methyl DNA-binding
factor complexes and
neurodegeneration.
Neuroprotection, methyl
DNA-binding factor,
epigenetics, cell biology,
mouse model.
20062009
86,102
255,036
I
Fehlings, Michael
G.; Velumian,
Alexander A.
University Health
Network
The ischemic axon: cross-talk
with myelin in K+ channel
terms.
Myelinated axons,
oligodendrocytes, glutamate
receptors, K+ channels,
conduction block.
20082011
84,389
84,389
I
Feindel,
Christopher M.;
Rao, Vivek
University Health
Network
Erythropoietin and hypertonic
saline for cardiac transplant.
Cardiac transplant,
myocardial function,
cytokine, hypertonic saline,
erythropoietin.
20062009
92,900
276,248
I
Feldman, Ross D.;
van Uum, Stanislaus
H.M.
Robarts Research
Institute
Determinants of adenylyl
cyclase mediated vascular
responses.
Vascular biology, adenylyl
cyclase, molecular biology,
cellular biology, hypertension.
20072009
110,850
220,349
I,II
Feldman, Ross D.;
van Uum, Stanislaus
H.M.
Robarts Research
Institute
Acute vascular effects of
aldosterone.
Aldosterone, hypertension,
vascular biology, estrogen.
20072009
78,016
154,566
I,II
Feng, Qingping,
Xenocostas,
Anargyros
London Health
Sciences Centre
Cardioprotection by
erythropoietin: role of nitric
oxide
Erythropoietin, nitric oxide
synthase, apoptosis, heart
failure, myocardial infarction.
20072012
122,126
241,858
I
Feng, Zhong-Ping
University of
Toronto
Modulatory mechanisms
underlying expression of
cardiac voltage-dependent
calcium channels.
Calcium channel density,
surface expression, gene
expression, endocytosis,
protein kinases, cardiac
myocytes.
20062009
62,250
186,750
I
Ferguson, Alastair
V.
Queen's University
Adiponectin actions in
autonomic control centres of
the brain.
Paraventricular nucleus, area
postrema, adiponectin, patch
clamp.
20072012
120,661
239,368
I
Ferguson, Stephen
S.G.
Robarts Research
Institute
Regulation of G proteincoupled receptor signaling
desensitization and
resensitization.
Small G proteins,
angiotensin, beta-adrenergic
receptor, desensitization,
resensitization, protein
kinases.
20062011
123,041
364,090
I
Floras, John S.;
Harvey, Paula J.
University Health
Network
Neural regulation of the
circulation in human heart
failure and hypertension.
Autonomic nervous system,
heart failure, heart rate
variability, microneurography,
sympathetic nervous system.
20082011
128,257
128,257
I,II
Investigator
Emili, Andrew;
Gramolini, Anthony
O.
Cumulative Theme
$ to 2009
82
08-09 $
Keywords
08-09 $
Cumulative Theme
Investigator
Floras, John S.;
Bradley, T. Douglas
University Health
Network
Central regulation of
autonomic cardiovascular
function in human heart failure
and sleep apnea.
Heart failure, obstructive
sleep apnea, functional
magnetic resonance imaging,
heart rate variability, muscle
sympathetic nerve activity.
20082011
72,621
72,621
I,II
Fowler, Robert A.;
Mittman, Nicole;
Cook, Deborah J.;
Dodek, Peter M.;
Gould, Michael K.;
Geerts, William H.;
Guyatt, Gordon H.
Sunnybrook
Health Sciences
Centre
E-PROTECT: prospective
economic analysis in
the prophylaxis for
thromboembolism in critical
care trial.
Thromboembolism,
prophylaxis, cost, economic,
burden.
20082011
76,076
76,076
II,III,IV
Fremes, Stephen
E.; Feindel,
Christopher M.;
Novick, Richard
J.; Rubens, Fraser
D.; Tu, Jack V.;
Anderson, Geoffrey
M.; Mazer, C.
David; Guru, Veena;
Adhikari, Neill K.J.;
Fowler, Robert A.;
Scales, Damon C.
Sunnybrook
Health Sciences
Centre
Unraveling the black box of
adverse events in cardiac
surgery.
Adverse events, patient
safety, cardiac surgery, quality
of care, independent audit,
best evidence, best practices,
safety culture.
20062009
88,850
260,950
II,III
Funk, Colin D.
Queen's University
COX-2 pathway and
Prostaglandin,
cyclooxygenase,
atherosclerosis, aortic
aneurysm, thrombosis.
20062009
119,470
353,501
I
Gagnon, France;
Wells, Philip S.;
Bulman, Dennis E.
University of
Toronto
Genome-wide search for
oligogenes in factor V leiden
thrombophilia.
Thrombosis, genetic
epidemiology, quantitative
traits, thrombophilia, complex
disease.
20082011
107,355
107,355
I,II,IV
Gaisano, Herbert Y.
University of
Toronto
SNARE regulation of cardiac
sulfonylurea receptor, a novel
drug target for cardiac ishemia.
ATP-sensitive potassium
channels, SNARE proteins,
electrophysiology,
cardiac myocytes, protein
interactions.
20072011
101,479
201,196
I
Gao, Yu-Jing; Lee,
Robert M.K.W.
McMaster
University
Perivascular adipose tissue,
reactive oxygen species, and
hypertension.
Perivascular adipose tissue,
hypertension, reactive oxygen
species, vascular biology,
cardiovascular physiology.
20072009
74,460
151,104
I
Giacca, Adria;
Fantus, Ivan G.;
Bendeck, Michelle
P.
University of
Toronto
Vasculoprotective effect of
insulin in vivo.
Hyperinsulinemia, insulin
resistance, restenosis, apo
E-null mouse, atherosclerosis.
20082011
76,668
76,668
I,II
Project
Term
$ to 2009
II: Clinical
83
Project
08-09 $
Cumulative Theme
Investigator
Gilbert, Richard E.;
Connelly, Kim A.
St. Michael's
Hospital
Pathogenetic role of protein
kinase C-beta in diabetic
cardiomyopathy: interventional
and translational studies.
Diabetes, heart failure,
protein kinase C, diastole,
cardiomyopathy.
20072009
110,086
218,713
I,II,IV
Gollob, Michael H.;
Roberts, Robert;
Beanlands, Rob
S. B.; de Kemp,
Robert A.; Stewart,
Alexandre F.R.
University of
Ottawa Heart
Institute
Pathophysiologic study of
the role of AMPK in cardiac
arrhythmias, conduction system
development, and metabolic
cardiomyopathy.
Arrhythmia, cardiomyopathy,
electrophysiology.
20062009
79,531
237,047
I,II
Gorczynski,
Reginald M.
University Health
Network
Regulation of transplant
rejection and inflammation
in CD200tg and CD200R KO
mice.
Cardiac transplantation,
cytokines, inflammation,
immunoregulation, regulatory
T cells.
20072010
92,208
182,608
I,II
Gotlieb, Avrum I.
University Health
Network
Cell biology of heart valve
interstitial cells.
Heart valve, tissue repair,
interstitial cell, growth
factors, matrix,cardiovascular
pathology, endocardial
endothelial cell, cell motility.
20072009
90,516
179,296
I
Graham, Charles
H.; Adams, Michael
A.
Queen's University
Mechanisms regulating
the development and
pathophysiology of
pre-eclamptic hypertension.
Hypertension, pre-eclampsia,
pregnancy, apoptosis, nitric
oxide.
20072010
96,792
191,735
I
Graham, Simon J.;
Ween, Jon Erik
Baycrest Centre
for Geriatric Care
Further development of fMRI
technology applied to stroke
recovery.
fMRI, stroke recovery,
sensorimotor systems,
simulation.
20082010
79,406
79,406
I,II
Gramolini, Anthony
O.
University of
Toronto
Investigation of
phospholamban mutations,
sarcoplasmic reticulum
calcium defects, and dilated
cardiomyopathy.
Cardiac disease, calcium
signaling, intracellular
trafficking, endoplasmic
reticulum (ER) stress.
20082011
93,400
93,400
I,II
Grant, David;
Adamson, S.
Lee; Gorczynski,
Reginald M.; Levy,
Gary; Phillips,
James M.
Toronto General
Hospital
fgl2/FGL2 and xenograft
transplantation.
Thrombosis, transplantation,
macrophage, endothelial
cells, fibrin.
20082011
88,600
88,600
I
Grinstein, Sergio;
Trimble, William S.
Hospital for Sick
Children
Dual role of CD36 in
macrophages: atherosclerosis
and immune responsiveness.
Macrophage, CD36,
receptor, signal transduction,
endocytosis.
20062010
87,596
252,740
I
Gross, Gil J.
Hospital for Sick
Children
Ventricular repolarization
in bradycardic electrical
remodelling.
Complete heart block,
cardiac pacing, repolarizing
currents, ventricular electrical
remodeling, autonomic
regulation.
20072010
89,674
176,588
I
Gross, Peter L.
McMaster
University
Defining how atorvastatin
inhibits platelets.
Statins, animal model,
thrombosis, S-nitrosylation,
prenylation.
20072009
75,148
146,414
I
$ to 2009
84
Keywords
Term
Project
Keywords
Term
McMaster
University
Effects of reactive oxygen on
Na-Ca exchange in coronary
artery.
Sodium calcium exchange,
smooth muscle, coronary
arteries, cardiac ischemia,
free radicals.
20072010
101,514
205,951
I
Grover, Ashok K.
McMaster
University
Caloxins: novel inhibitors of
plasma membrane calcium
pumps.
Calcium pumps, phage
display, drug discovery,
cardiovascular.
20082011
76,928
76,928
I
Gupta, Radhey S.
McMaster
University
Studies on mammalian
adenosine kinase and its
inhibitors.
Adensosine kinase,
ribokinase, enzyme inhibitors,
structure-activity studies,
gene regulation, kinetic
studies, genetic studies.
20072010
87,879
175,481
I
Haas, Tara L.
York University
The regulation of angiogenic
factors by shear stress.
Angiogenesis, endothelium,
ischemia, skeletal muscle,
shear stress.
20072009
79,750
159,500
I
Haché, Robert J. G.
Ottawa Health
Research Institute
Regulation of human primary
preadipocyte differentiation by
glucocorticoids.
Metabolic disease, obesity,
glucocorticoid hormone
action, preadipocyte
differentiation, control of
white fat deposition.
20062009
93,779
275,858
I
Hamilton, Robert
M.; Chauhan, Vijay
S.; Scherer, Stephen
W.
Hospital for Sick
Children
Intercalated disc protein
expression in arrhythmogenic
right ventricular
cardiomyopathy.
Cardiomyopathy, genetics,
desmosome, gap junction,
arrhythmia.
20082010
72,100
72,100
I,II
Hammond, James
R.
University of
Western Ontario
Role of nucleoside/nucleobase
transporters in the regulation
of the vascular effects of
adenosine and its metabolites.
Adenosine, transporters,
ischemia, vasodilators,
hypoxanthine.
20082011
75,900
75,900
I
Harper, Mary-Ellen;
McPherson, Ruth
University of
Ottawa
Novel AMPK - gamma
mutations in humans:
implications for skeletal muscle
energy metabolism.
Human differentiated muscle
satellite cells, diabetes,
obesity, positron emission
tomography, indirect
calorimetry.
20072010
100,324
194,049
I,II,IV
Hayward, Catherine
P.M.
McMaster
University
Structure-function analysis
of multimerin 1 proadhesive
function.
Platelet adhesion, vascular
adhesion, leukocyte
adhesion, aggregation,
multimerin 1.
20062009
93,251
322,071
I
Hayward, Catherine
P.M.
McMaster
University
Studies of the mechanisms
involved in generating
profibrinolytic and
antifibrinolytic human platelets.
Platelets, fibrinolysis, stroke,
Quebec Platelet Disorder,
urokinase-type plasminogen
activator.
20062009
82,299
244,132
I,II
Hegele, Robert A.
Robarts Research
Institute
Genomics of
hypertriglyceridemia.
Atherosclerosis, dyslipidemia,
tryglycerides, genetics, DNA.
20072009
110,372
218,580
I,II,IV
Hegele, Robert A.
Robarts Research
Institute
Phenomics and genomics of
atherosclerosis in monogenic
metabolic syndrome.
Atherosclerosis, dyslipidemia,
diabetes, metabolic
syndrome, genetics.
20072012
110,723
220,722
I,II,IV
Investigator
Grover, Ashok K.
08-09 $
Cumulative Theme
$ to 2009
II: Clinical
85
Project
Keywords
Term
University of
Toronto
Defining the role of RGS2 as a
mediator of vascular signaling
and blood pressure regulation.
RGS protein, heterotrimeric
G-protein signaling,
hypertension, vascular
smooth muscle cell, cyclic
nucleotide-mediated
vasodilation.
20062009
109,623
322,874
I
Hinek, Aleksander
Hospital for Sick
Children
Elastin and elastin receptor as
crucial factors modulationg
cellular funtions in
cardiovascular development
and diseases.
Elastin, elastin receptor,
arterial smooth muscle cells,
cellular proliferation, pediatric
diseases with arterial
occlusions.
20082013
118,060
118,060
I
Holdsworth, David
W.; Poepping,
Tamie L.; Rankin,
Richard N.
Robarts Research
Institute
Investigation of flow in the
stenosed carotid bifurcation.
Stroke, carotid bifurcation
disease, doppler ultrasound,
hemodynamics, artery-toartery embolization.
20082013
117,236
117,236
I,II
Hou, Sheng T.
University of
Ottawa
Semaphorin-3A's role in axonal
degeneration and regeneration
following cerebral ischemia.
Semaphorin, neuropilin, axon,
regeneration, stroke.
20062009
65,392
189,274
I
Hough, Margaret
R.; Dick, Alexander
J.
Sunnybrook
Health Sciences
Centre
Cardiac repair and
regeneration.
Stem cells, in vivo
differentiation,
cardiomyocytes, canine
model, cardiac regeneration.
20062009
91,113
263,519
I
Huff, Murray W.
Robarts Research
Institute
Regulation of ApoB
metabolism: relationship to
atherosclerosis.
20052010
136,879
540,117
I
Husain, Mansoor;
Drucker, Daniel J.
Toronto General
Hospital
Role of glucagon-like peptides
in cardiac health and disease.
Glucagon peptides and
receptors, myocardial
infarction, heart failure,
transgenic mice, knockout
mice.
20062009
116,909
371,349
I
Hutchison, James
S.; Stanimirovic,
Danica B.
Hospital for Sick
Children
Adhesion receptors following
global cerebral ischemia: Role
of adhesion receptor blockade/
knockout and hypothermia
therapy.
Cerebral ischemia,
hypothermia therapy,
inflammation, cell death,
morris water maze.
20072009
71,380
141,360
I
Igdoura, Suleiman
A.; Trigatti,
Bernardo L.
McMaster
University
Molecular impact of sialidase
on atherosclerosis in transgenic
mice.
Lipoproteins, atherosclerosis,
macrophage, sialylation,
ApoE, LDL, transgenic.
20082010
80,000
80,000
I
Ikura, Mitsuhiko
Ontario Cancer
Institute
Structural elucidation
of intracellular calcium
transporters.
Ca2+ transport, structural
biology, endoplasmic
reticulum, molecular
recognition, inositol
phosphate.
20062011
102,377
302,919
I
Iscoe, Steve D.
Queen's University
Inspiratory occlusion-induced
cardiac dysfunction in rats and
mice.
Heart, airway occlusion,
contractility, oxidative stress,
heme-oxygenase 1.
20082010
72,189
72,189
I
Investigator
Heximer, Scott P.
Cumulative Theme
$ to 2009
86
08-09 $
Cumulative Theme
Investigator
Karmazyn, Morris;
Cook, Michael A.
University of
Western Ontario
Role of adenosine in
myocardial hypertrophy and
heart failure.
Adenosine, adenosine
receptors, hypertrophy, heart
failure, aging.
20072010
95,610
189,443
I
Karmazyn, Morris
University of
Western Ontario
Modulation of cardiomyocyte
hypertrophy by nitric oxide
and endothelin-1 in the aging
myocardium.
Nitric oxide, endothelin,
cardiac hypertrophy, heart
failure, aging, gender.
20052009
102,526
395,505
I
Kawaja, Michael D.
Queen's University
Evaluating phenotypic
changes in cerebral vessels of
stroke-prone spontaneously
hypertensive rats: a pilot
proteomic investigation.
Proteomics, stroke-prone
rat, hypertension, vascular,
malfunction.
20072009
68,042
134,804
I
Keeley, Fred W.
Hospital for Sick
Children
Recombinantly expressed
polypeptides of human
elastin as a novel tool for
investigations of the structure,
self-assembly and properties of
elastin-like materials.
Elastin, elastic tissue, blood
vessels, extracellular matrix,
biomaterial.
20042009
115,923
557,707
I
Kelton, John G.;
Moore, Jane C.;
Begbie, Megan E.
McMaster
University
Platelet-mediated acute
thrombotic disorders.
Platelets, immune,
thrombocytopenia, heparin,
thrombosis.
20052010
149,413
573,021
I,II
Khan, Nadia A.;
St. Paul's Hospital
Hill, Michael D.;
Hsiung, Ging-Yuek
R.; Humphries,
Karin H.; Kapral,
Moira K.; McAlister,
Finlay A.; Palepu,
Anita; Pilote,
Louise; Quan, Hude
stroke prognosis and quality
of care.
Ethnicity, stroke,
administrative data, sex,
mortality.
20082010
21,450
21,450
II,III
Khokha, Rama
Ontario Cancer
Institute
Molecular dissection of the
distinct functions of TIMP-3
and TIMP-4 in heart disease.
TIMP deficiency,
metalloproteinase, cytokines,
ECM, heart disease.
20062009
75,861
227,583
I
Koschinsky, Marlys
L.; Boffa, Michael
B.; Nesheim,
Michael E.
Queen's University
Modulation of the TAFI
pathway in health and disease:
mechanistic analysis of the
regulation of TAFI gene
expression in hepatic and
extrahepatic cells.
TAFI, fibrinolysis,
inflammation, transcription,
mRNA stability.
20082012
113,328
113,328
I
Koschinsky, Marlys
Queen's University
Interactions of Lp(a)
with the plasminogen
system: mechanisms
and pathophysiological
consequences.
Lipoprotein(a),
apoliprotein(a), plasminogen,
thrombosis, atherosclerosis.
20052010
101,667
390,289
I
Queen's University
The pathophysiology of Lp(a)
in the arterial wall: effect
of Apo(a) on vascular cell
function.
Lipoprotein(a),
apolipoprotein(a), kringles,
atherosclerosis, endothelial
dysfunction.
20062011
100,600
296,240
I
$ to 2009
L.
Keywords
08-09 $
Koschinsky, Marlys
L.
Project
Term
II: Clinical
87
Project
08-09 $
Cumulative Theme
Investigator
Krahn, Andrew D.;
Gollob, Michael H.;
Birnie, David H.
University of
Western Ontario
Clinical and genetic
assessment of primary
electrical disease.
Cardiac arrest, genetics,
diagnosis, sudden death,
drug infusion, genetic testing.
20062009
97,231
288,299
II
Lanctôt, Krista L.;
Herrmann, Nathan;
Albert, Paul R.;
Aviv, Richard;
Black, Sandra E.;
Gao, Fuqiang;
Gladstone, David
J.; Snaiderman,
Abraham
Sunnybrook
Health Sciences
Centre
The role of cytokine-serotonin
interactions in post-stroke
depression and cognitive
symptoms.
Stroke, depression, cognition,
cytokines, kunurenine.
20082011
97,113
97,113
I,II
Lee, Jonathan M.
University of
Ottawa
The role of elongation factor
eEF1A2 in obesity.
Obesity, ovary, phospholipid,
signaling, metabolism.
20082011
69,024
69,024
I
Lee, Robert M.K.W.
McMaster
University
Alterations in hypertensive
arteries.
Hypertension, diabetes,
artery, fat, vascular function.
20082010
78,280
78,280
I
Leenen, Frans H.H.;
Ascah, Kathryn J.;
Davies, Ross A.;
Le May, Michel R.;
Ruzicka, Marcel
University of
Ottawa Heart
Institute
RAS blockade and sympathetic
activity in humans post MI.
Brain, heart, reninangiotensin-aldosterone
system, heart failure, blockers,
sympathetic nerve activity.
20082011
106,381
106,381
II
Letarte, Michelle V.
Hospital for Sick
Children
Role of endoglin in normal
vasculature and in the
pathology of HHT.
Vascular tone, endoglin, HHT,
vascular endothelium, gene
profiling.
20052009
95,321
370,767
I
Levin, Mindy F.;
Sveistrup, Heidi;
Ptito, Alain
McGill University
Optimizing arm motor recovery
in stroke.
Rehabilitation, recovery,
stroke, virtual reality, exercise.
20072010
33,100
74,862
I,II,III
Lewis, Gary F.
Toronto General
Hospital
The role of C-reactive protein
(CRP) in modulating insulin
action and insulin secretion.
C-reactive protein, human
c-reative protein transgenic
mice, insulin sensitivity, insulin
secretion, euglycemic and
hyperglycemic clamps.
20082011
83,000
83,000
I
Leytin, Valery
St. Michael's
Hospital
Mitochondrial control of
platelet apoptosis.
Platelets, apoptosis,
mitochondria, mitochondrial
transmembrane potential,
Bcl-2 family proteins.
20082013
94,954
94,954
I
Li, Ren-Ke
Toronto General
Hospital
Matrix modulation is required
to restore cardiac function after
cell therapy.
Heart failure, growth
factor, cell transplantation,
myocardial hypertrophy,
extracellular matrix.
20072009
94,497
185,740
I
Liaw, Patricia C.Y.
McMaster
University
Studies of the endothelial cell
protein C receptor (EPCR).
Protein C pathway,
EPCR, thrombomodulin,
endothelium, factor VIIa.
20082011
121,160
121,160
I
$ to 2009
88
Keywords
Term
Keywords
08-09 $
Cumulative Theme
Investigator
Lillicrap, David P.;
Othman, Maha
Queen's University
Gain-of-function mutants
affecting the glycoprotein
Ib/von Willebrand factor
interaction: Potential novel
antithrombotic molecules.
Thrombosis, von
Willebrand factor, platelets,
antithrombotic.
20082013
138,494
138,494
I
Linkins, LoriAnn; Warkentin,
Theodore E.; Lee,
Agnes Y.Y.; Bates,
Shannon M.; KoruSengal, Tulay
McMaster
University
Improving the diagnosis
of heparin-induced
thrombocytopenia: utility of the
4T's score and evaluation of
new rapid assays.
Heparin-induced
thrombocytopenia,
clinical prediction rule,
thromboembolism.
20072009
103,722
206,220
II
Linkins, Lori-Ann;
Kearon, Clive;
Bates, Shannon M.;
Douketis, James
D.D.; Ginsberg,
Jeffrey S; Julian,
Jim A.; Kahn, Susan
R.; Lang, Eddy S.;
Schulman, Sam
McMaster
University
Selective D-dimer testing
for diagnosis of deep vein
thrombosis.
Deep vein thrombosis,
diagnostic test, D-dimer,
clinical trial, ultrasound.
20082009
145,200
145,200
II
Liu, Fang
Centre for
Addiction and
Mental Health
Functional and molecular
characterization of proteinprotein interaction between
AMPA receptors and GAPDH
(Glyceraldehyde-3-phosphate
Dehydrogenase).
AMPA receptors,
glyceraldehyde-3-phosphatedehydrogenase, neurotoxicity,
stroke.
20082013
95,300
95,300
I
Liu, Peter P.
Toronto General
Hospital
"Danger signal", cell injury and
"innate immune response"
in regulating inflammation in
Inflammation, myocarditis,
innate immunity, vaccine,
heart failure.
20052010
111,062
431,352
I,II
Liu, Peter P.; Medin,
Jeffrey A.
Toronto General
Hospital
Homing signals and cell
mobilization in cardiac
remodeling post myocardial
infarction.
Heart failure, remodeling,
cytokines, stem cells,
progenitor cells, homing,
innate immunity.
20062009
98,341
290,233
I,II
Logan, Alexander
G.; Bradley, T.
Douglas
Mount Sinai
Hospital
Role of extracellular fluid
volume in inducing obstructive
sleep apnea in refractory
hypertension.
Hypertension,
extracellular fluid volume,
obstructive sleep apnea,
hyperaldosteronism, obesity.
20082010
51,020
51,020
I,II
Mak, Alan S.
Queen's University
Cortactin and caldesmon in
vascular smooth muscle cell
migration and invasion.
Smooth muscle, cell motility,
atherosclerosis, biochemistry,
cell biology.
20062011
96,865
285,249
I
Mak, Susanna;
Floras, John S.;
Parker, John D.;
Granton, John
Thomas; Azevedo,
Eduardo
Mount Sinai
Hospital
Studies of sympathetic nervous
system activation in patients
with pulmonary arterial
hypertension.
Autonomic physiology,
norepinephrine,
microneurography, pulmonary
hypertension.
20082011
57,596
57,596
I,II
Project
Term
$ to 2009
II: Clinical
89
Project
08-09 $
Cumulative Theme
Investigator
Mak, Susanna
Mount Sinai
Hospital
Sex determinants of left
ventricular mechanical
performance in humans with
and without heart failure.
Sex, ventricular function,
contractility, heart failure,
human.
20082011
64,126
64,126
I,II
Marcel, Yves L.;
McPherson, Ruth
University of
Ottawa Heart
Institute
The genetic basis of
cholesterol efflux defects in
hypoalphalipoproteinemia.
Atherosclerosis,
dyslipoproteinemia,
cholesterol, efflux,
lipoproteins.
20062009
94,746
280,989
I
Marsden, Philip A.
University of
Toronto
Post-transcriptional regulation
of eNOS expression.
Nitric oxide, endothelium,
atherosclerosis, transcription,
translation.
20052009
95,069
380,276
I
Marsden, Philip A.
University of
Toronto
Regulated expression of the
human nNOS gene.
Atherosclerosis, hypoxia,
translation, nitric oxide,
transcription.
20062011
112,578
332,997
I
Martino, Tami A.
University of
Toronto
Circadian control of cardiac
remodeling.
Circadian rhythm, diurnal
rhythm, myocardial infarction,
biomarkers, genomics and
proteomics.
20082011
77,700
77,700
I,II
Maurice, Donald H.
Queen's University
Phosphodiesterases in arteries.
Phosphodiesterase, cAMP,
artery, smooth muscle,
restenosis.
20082011
91,695
91,695
I
McBride, Heidi M.
University of
Ottawa Heart
Institute
Mechanism and function of
mitochondrial derived vesicles.
Mitochondrial dynamics,
vesicles, ros-induced damage,
intracellular transport.
20082013
122,333
122,333
I
McCulloch,
Christopher A.G.;
Simmons, Craig A.
University of
Toronto
Regulation of myofibroblast
differentiation by mechanical
loading.
Cardiac hypertrophy, force,
smooth muscle actin, small
GTPases, fibrosis.
20072010
98,082
195,103
I
McDonald, Sarah
D.; Lonn, Eva M.;
Ray, Joel G.; Teo,
Koon K.; Yusuf,
Salim
McMaster
University
The CAP study: cardiovascular
disease after preeclampsia.
Preeclampsia, cardiovascular
disease, cerebrovascular
disease, peripheral vascular
disease, carotid intima-media
thickness.
20082010
161,352
161,352
I,II
McPherson, Ruth
University of
Ottawa Heart
Institute
HDL-C.
Lipoproteins, genetics,
HDL-C, obesity, CHD.
20072010
134,607
267,789
I
Megeney, Lynn
Ottawa Health
Research Institute
Caspase mediated induction of
cardiac hypertrophy.
Apoptosis, signaling,
hypertrophy.
20072009
81,066
162,132
I
Mehta, Sanjay
Lawson Health
Research Institute
Complex regulation of
microvascular endothelial cell
function in sepsis.
Inflammation/sepsis,
microvascular endothelium,
alveolar epithelium,
macrophages, cell signaling,
leukocytes.
20082013
118,905
118,905
I
Mequanint, Kibret;
Sandig, Martin
University of
Western Ontario
Vascular smooth muscle cell
phenotype switching and
elastin synthesis in 3D tissue
engineered coronary artery
substitutes.
Cardiovascular disease, tissue
engineering of blood vessels,
smooth muscle cells, elastin,
bioreactor.
20082010
79,800
79,800
I
$ to 2009
90
Keywords
Term
Keywords
08-09 $
Cumulative Theme
Investigator
Milne, Ross W.;
Braschi, Sylvie F.;
Whitman, Stewart
C.
University of
Ottawa Heart
Institute
Advanced glycation end
products and diabetic
atherosclerosis.
Diabetes, atherosclerosis,
transgenic mice, gene
expression, endothelial cells.
20072010
69,794
141,471
I
Morris, Catherine E.
Ottawa Health
Research Institute
The mechanosensitivity of
pacemaker channels.
Pacemaker channels,
mechano-electric feedback,
patch-clamp, recombinant
proteins, fibrillation,
arrhythmias.
20072010
80,914
161,828
I
Morshead, Cindi
M.; Corbett, Dale
R.; Shoichet, Molly
S.
University of
Toronto
The development of drug and
cell delivery systems for use in
stem cell based therapies to
treat stroke.
Drug and cell delivery, neural
stem cells, transplantation,
endogenous stimulation,
rehabilitation.
20082011
153,110
153,110
I
Nag, Sukriti;
Stewart, Duncan J.
University of
Toronto
Regulation of cerebrovascular
homeostasis and repair by
angiogenic factors.
Cerebral vessels, blood-brain
barrier, angiogenesis, growth
factors, angiopoietins,
caveolin-1, tight junction
proteins.
20072009
89,595
177,434
I
Neilipovitz, David
T.; Bryson, Gregory
L.
The Ottawa
Hospital
Short term atorvastatin regime
for vascular surgery (STAR VaS)
Study.
Statins, perioperative,
complications, cardiovascular,
inflammation.
20082010
78,214
78,214
II
Nemer, Mona
University of
Ottawa
Mechanisms of TBX5 action in
the heart.
Heart development,
transcription factors,
endocardium, transgenic
mice, congenital heart
disease.
20082011
118,196
118,196
I
Nesheim, Michael
E.
Queen's University
The activation of TAFI and the
properties of TAFIa.
TAFI, TAFIa, fibrinolysis,
x-ray crystallography,
thrombomodulin.
20052010
90,699
348,992
I,III
Ng, Dominic S.
St. Michael's
Hospital
Regulation of lipids, insulin
action and cell stress in LCAT
deficient mice.
LCAT, HDL, ER stress,
atherosclerosis, inslulin stress.
20082011
107,530
107,530
I,II
Ni, Heyu
St. Michael's
Hospital
Novel mechanisms of platelet
aggregation: unveiling new
roles of non-classical beta3
integrin ligands in thrombosis
and hemostasis.
Platelet, thrombosis, integrin,
hemostasis, vascular biology.
20082012
120,901
120,901
I
Nurse, Colin A.
McMaster
University
Mechanisms regulating
asphyxial responses in rat
adrenal chromaffin cells.
Chromaffin cells, asphyxia,
patch clamp, nicotine, culture.
20062010
84,325
270,634
I,II,III,IV
O'Brien, Edward
R.M.
University of
Ottawa Heart
Institute
Extracellular and intracellular
vascular roles of HSP27: an
estrogen receptor beta
associated heat shock protein.
Estrogen, receptor,
atherosclerosis, hormone,
women.
20082011
77,400
77,400
I,II
Project
Term
$ to 2009
II: Clinical
91
Investigator
Project
Keywords
Term
08-09 $
Cumulative Theme
$ to 2009
O'Donnell, Martin
McMaster
J.; Yusuf, Salim;
University
McQueen, Matthew
J.; Oczkowski,
Wieslaw J.
Interstroke (Pilot): Importance
of conventional and emerging
risk factors for stroke in
different regions of the world
and in different ethnic groups
(Lipids, Glucose, and Sodium).
Stroke, epidemiology,
population health,
international case control
study.
20082010
112,160
112,160
I,IV
Ofosu, Frederick A.
McMaster
University
Platelet-derived serine
proteases and platelet
activation.
Platelet activation, blood
coagulation, hemostasis,
thrombin receptors.
20072009
70,398
140,796
I
Ooi, Teik Chye;
Taljaard, Monica;
Mayne, Janice E.;
Mbikay, Majambu;
Chretien, Michel
Ottawa Hospital
Research Institute
Human studies on gender
differences in PCSK9 function
in lipoprotein metabolism.
PCSK9, lipids, testosterone,
estrogen, gender.
20082010
95,400
95,400
I,II
Opas, Michal
University of
Toronto
Calreticulin: cell and
developmental biology.
Calreticulin, calcium,
adhesion, ES cells,
differentiation, microscopy.
20072010
107,923
221,524
I
Opavsky, Mary
Anne
Hospital for Sick
Children
Heart failure and the coxsackieadenovirus receptor (CAR):
insights through a novel heart
targeted CAR transgenic
mouse.
Heart failure, myocarditis,
coxsackieadenovirus
receptor, coxsackievirus,
signal transduction.
20072010
92,114
185,965
I
Pandey, Siyaram;
Tanha, Jamshid
University of
Windsor
Identification and functional
characterization of unique
single domain intrabodies
against pro-apoptotic
proteins and their application
in the discovery of novel
pharmacophore.
Intrabodies, apoptosis,
neuronal cell death, ischemia,
anti-apoptotic intrabodies,
phage display and
pharmacophore libraries.
20062009
61,000
198,000
I
Pang, Stephen C.;
Graham, Charles H.
Queen's University
Hypoxia inducible expression
of atrial natriuretic peptide: a
potential preemptive therapy
for myocardial infarction.
Myocardial infarct, ischemia/
reperfunsion injury, gene
therapy, atrial natriuretic
peptide, hypoxia.
20072010
84,452
169,466
I
Park, David S.;
Albert, Paul
University of
Ottawa
Mechanisms of delayed death
in stroke.
Central nervous system,
stroke, behaviour
abnormalities.
20042009
80,600
403,000
I
Park, David S.
University of
Ottawa
Oxidative stress and ischemic
death.
DJ-1, PRDZX2, oxidative
stress, ROS, NRF2.
20082013
118,600
118,600
I
Parker, John D.
Mount Sinai
Hospital
Development of a new
technique to assess endothelial
function: flow mediated
constriction.
Endothelial function, vascular
ultrasound, flow mediated
dilation, nitric oxide sythase.
20082013
130,366
130,366
I,II
Parker, Thomas G.
St. Michael's
Hospital
EF-hand proteins, S100A1
and A6, in cardiovascular
pathophysiology.
Cardiac hypertrophy,
hypertension, calciumbinding proteins, gene
expression, apoptosis.
20082013
115,150
115,150
I
92
Project
Keywords
Term
Hospital for Sick
Children
A combined theoretical/
experimental approach to
understanding sequencestructure-function relationships
in elastin.
Elastin, biomechanics,
sequence variation,
bioinformation, computer
simulation.
20072009
58,548
115,948
I,IV
Peng, Tianqing;
Feng, Qingping
London Health
Sciences Centre
PLCgamma/IP3 signaling
regulates cardiac TNF-alpha
expression in sepsis.
Sepsis, TNF-alpha,
cardiomyocyte,
phospholipase Cgamma,
inositol trisphosphate.
20062009
98,805
323,859
I
Peng, Tianqing
London Health
Sciences Centre
Role of calpain activation in
myocardial dysfunction in
sepsis.
Sepsis, heart function,
calpain, caspase-3,
cardiomyocytes.
20082011
122,162
122,162
I
Pickering, J.
Geoffrey
Robarts Research
Institute
Regulation of smooth muscle
cell differentiation and
longevity.
Smooth muscle cell, cell
maturation, cell longevity,
NAD, vessel remodeling.
20052010
107,295
416,719
I
Pilote, Louise;
Karp, Igor;
Bacon, Simon L;
Chalifour, Lorraine
E.; Cox, Jafna L.;
Dasgupta, Kaberi;
Daskalopoulou,
Styliani-Stella;
Eisenberg, Mark
J.; Engert , James
C.; Ghali, William
A.; Hamet, Pavel;
Humphries, Karin
H.; Khan, Nadia
A.; Lavoie, Kim L.;
Norris, Colleen
M.; Rabi, Doreen
M.; Stark, Ken D.;
Tagalakis, Vicky;
Tremblay, André;
Tu, Jack V.
McGill University
syndrome.
20082011
45,524
45,524
II,III,IV
Radisic, Milica; Li,
Ren-Ke
University of
Toronto
Peptide modified
photocrosslinkable chitosan
for cell therapy in myocardial
infarction.
Cell therapy, infarcted
myocardium,
photocrosslinkable hydrogel,
chitosan, angiopoietin, tissue
engineering.
20072010
52,154
103,128
I
Rand, Margaret L.
Hospital for Sick
Children
The procoagulant surface of
activated platelets: persistence
in vitro and in vivo.
Platelets, thrombosis,
procoagulant activity, platelet
senescence.
20072010
87,521
173,324
I
Reid, Robert D.;
Pipe, Andrew L.;
Sherrard, Heather
University of
Ottawa Heart
Institute
An interactive, voice responsemediated, follow-up and triage
system for smoking cessation
in smokers with CHD.
Smoking cessation, coronary
disease, prevention,
interactive voice response.
20062009
33,312
177,557
II,III,IV
Investigator
Parkinson, John;
Keeley, Fred W.
08-09 $
Cumulative Theme
$ to 2009
II: Clinical
93
Project
Keywords
Term
University of
Ottawa Heart
Institute
A program to reduce
cardiovascular risk among
family members of patients
with coronary heart disease.
family history, primary
prevention, randomized
controlled trial, lifestyle
modification.
20072010
93,050
193,393
II,III,IV
Reid, Robert D.;
Blanchard, Chris
M.; Higginson, Lyall
A.J.; Morrin, Louise
I.N.; Oldridge, Neil
B.; Pipe, Andrew L.;
Wells, George A.;
Wielgosz, Andreas
T.
University of
Ottawa Heart
Institute
Efficacy and cost-effectiveness
of behavioural counselling for
exercise behaviour in men and
women following AMI and PCI.
secondary prevention, early
intervention, physical activity.
20072009
73,375
148,016
II,III
Robinson, Lisa A.
Hospital for Sick
Children
Regulation of the membraneanchored chemokine,
fractalkine, by thromboxane
A2.
Chemokines, atherosclerosis,
cell biology, inflammation,
subcellular traffic.
20072010
89,480
178,348
I
Rochon, Elizabeth
A.; Leonard, Carol
L.; Grady, Cheryl L.;
Graham, Simon J.
University of
Toronto
Understanding the behavioural,
neural and communicative
changes underlying the
treatment for anomia in
aphasia.
Aphasia, anomia,
rehabilitation, neuroimaging,
communication.
20072009
92,328
181,498
I,II
Rose, David R.
University Health
Network
The molecular basis for starch
digestion in the intestine:
Human maltase-glucoamylase
and sucrase-isomaltase.
Obesity, starch digestion,
glycosyl hydrolases,
enzyme inhibitors, x-ray
crystallography.
20082013
82,604
82,604
I,II,III,IV
Roy, Eric A.; Black,
Sandra E.; Hebert,
Deborah; Adams,
Scott G.; Danckert,
James A.; Park,
Norman W.;
McIlroy, William E.;
Staines, W. Richard;
Dixon, Michael J.
University of
Waterloo
Neuropsychological profiles
and neuroanatomic correlates
of limb apraxia.
Apraxia, cognition and
action, brain imaging, stroke
recovery, memory.
20072012
69,864
139,728
I,II
Rui, Tao
Lawson Health
Research Institute
Role of HMGB1 in ischemia/
reperfusion-induced
myocardial injury.
Ischemia/reperfusion
injury, HMGB1, apoptosis,
cell signaling, myocardial
dysfunction.
20082011
95,208
95,208
I
Investigator
Reid, Robert D.;
Mosca, Lori J.;
Pipe, Andrew L.;
Mochari, Heidi Y.;
Wells, George A.;
O'Farrell, Patricia
L.; Blanchard, Chris
M.; Papadakis,
Sophia; Slovinec
08-09 $
Cumulative Theme
$ to 2009
D'Angelo, Monika
E.M.; Beaton,
Louise
94
Project
Keywords
Term
University of
Waterloo
Vascular endothelium
adaptations to hypertension
and exercise.
Exercise, hypertension,
endothelium, nitric oxide,
oxidative stress.
20072009
73,831
146,214
I
Sandig, Martin
University of
Western Ontario
Integrin signaling in monocyte
transendothelial migration.
Endothelium, monocytes,
diapedesis, integrins,
signaling.
20072009
84,265
167,062
I
Schlichter, Lyanne
C.
Toronto Western
Research Institute
Novel strategies to regulate
microglia activation and
neurotoxicity.
Potassium channels, CNS
inflammation, immune-cell
activation.
20062009
86,963
280,936
I
Schlichter, Lyanne
C.
Toronto Western
Research Institute
Pathophysiology and
inflammation after intracerebral
hemorrhage.
Neuroinflammation, ICH
model, immune cells,
molecule expression, protein
expression.
20082013
143,007
143,007
I
Shah, Baiju R.;
Institute for
Anand, Sonia S.;
Clinical Evaluative
Austin, Peter C.;
Sciences
Hux, Janet E.;
Manuel, Douglas G.
Diabetes care and outcomes
for people with Chinese and
South Asian origins.
Ethnicity, visible minority
groups, diabetes mellitus,
quality of care, health care
utilization.
20082011
103,369
103,369
III,IV
Shaughnessy,
Stephen G.;
Werstuck, Geoffrey
H.
McMaster
University
Mechanisms of vascular
calcification in diabetes
mellitus.
Diabetes, atherosclerosis,
vascular calcification,
osteoblast, smooth muscle
cells.
20072009
78,729
155,914
I
Sheffield, William P.
McMaster
University
The clot-targeting properties
of natural and engineered
antiplasmins.
Fibrinolysis, antiplasmin,
fibrin, cross-linking, hirudin.
20062009
83,308
245,991
I
Sheffield, William P.
McMaster
University
Exploring engineered serpins
as potential antithrombotic
agents.
Serpins, thrombosis, heparin
cofactor II, alpha-1-proteinase
inhibitor, thrombin.
20082012
93,967
93,967
I
Shoemaker, J.
Kevin; St. Lawrence,
Keith S.; Suskin,
Neville G.
University of
Western Ontario
Plasticity of corticalcardiovascular interactions in
vascular disease.
cortical autonomic network,
sympathetic nerve activity,
parasympathetic nervous
system, vascular mechanics,
cardiac rehabilitation.
20082011
79,756
79,756
I,II
Silverman, Earl
D.; Bargman,
Joanne M.; Bradley,
Timothy; Beyene,
Joseph
Hospital for Sick
Children
Role of chronic inflammation
and systemic lupus
erythematosus-related
factors in the development of
premature atherosclerosis in
pediatric SLE.
Atherosclerosis, systemic
lupus erythematosus, risk
factors for atherosclerosis,
pediatrics, surrogate markers
of atherosclerosis.
20062009
136,843
386,777
II,IV
Simmons, Craig
A.; McCulloch,
Christopher A.G.
University of
Toronto
The role of extracellular matrix
biomechanics in aortic valve
sclerosis.
Heart valve disease,
calcification, mechanobiology,
mechanotransduction, bone.
20072010
83,235
164,360
I
Investigator
Rush, James W.E.
08-09 $
Cumulative Theme
$ to 2009
II: Clinical
95
Project
Keywords
Term
Toronto General
Hospital
Neurodevelopmental
outcomes in offsprings of
women with heart disease.
Pregnancy, heart disease,
child outcomes.
20072009
40,070
80,140
II
Slack, Ruth S.
Ottawa Health
Research Institute
Mitochondrial dynamics in
neuronal injury.
Stroke, apoptosis, neurons,
mitochondrial, molecular.
20072010
109,773
217,875
I
Slack, Ruth S.
University of
Ottawa
Regulation of MCL-1 to treat
stroke.
Stroke, apoptosis, neurons,
transgenic mice, molecular.
20062011
101,388
300,016
I
Sled, John G.;
Adamson, S. Lee;
Kingdom, John C.P.
Hospital for Sick
Children
Three-dimensional
quantification of the placental
vasculature: relationship with
normal and abnormal fetal
growth and hemodynamics.
Intrauterine growth restriction
(IUGR), micro-CT, placenta,
micro-circulation.
20082010
75,626
75,626
I,II
Smith, Steven P.
Queen's University
Lipoprotein (a) in
atherosclerosis, assembly and
interaction with extracellular
matrix proteins.
Apolipoprotein (a), structural
biology, protein-ligand
interactions.
20072010
130,119
259,275
I
Sorisky, Alexander
Ottawa Health
Research Institute
Pro-atherogenic responses of
human adipocytes to TSH.
Adipocyte, IL-6, free fatty
acids, TSH signaling,
atherosclerosis.
20072010
93,039
184,254
I,II
Spafford, J. David;
Honek, John F.
University of
Waterloo
Structure-function analyses of
drug interactions with L-type
calcium channels.
L-type calcium channels,
dihydropyridines,
conopeptides, patch
clamp electrophysiology,
pharmacophore.
20082011
76,248
76,248
I
Sparks, Daniel L.
University of
Ottawa Heart
Institute
Regulation of ApoA-I
synthesis and secretion by
phosphatidylinositol.
HDL, cholesterol,
atherosclerosis, lipid
metabolism, liver, intestine.
20062009
101,836
300,608
I
Sparks, Daniel L.
University of
Ottawa Heart
Institute
The role of HDL in triglyceride
metabolism.
HDL, cholesterol,
apolipoproteins, lipases,
heart disease.
20082011
80,000
80,000
I
Spence, John
David; Fenster,
Aaron; House,
Andrew A.; Parraga,
Grace
Robarts Research
Institute
3D ultrasound phenotypes and
vascular risk.
Atherosclerosis, vulnerable
plaque, plaque volume,
ulceration, cardiovascular risk.
20062009
100,027
276,529
II
Stanford, William
L.; Ni, Heyu
University of
Toronto
Developmental and functional
characterization of novel
regulators of thrombopoiesis
identified by mouse
mutagenesis.
Thrombocytopenia,
throbocythemia, mouse
models of human disease,
megakaryocytes, platelets.
20082010
103,309
103,309
I
Stanimirovic,
Danica B.; Moreno,
Maria J.
National Research
Council of Canada
(Ottawa)
Astrocyte-endothelial cell
interactions in hypoxia: role of
P1GF in hypoxia-induced brain
angiogenesis.
Hypoxia, brain angiogenesis,
neurovascular unit, placentagrowth factor, VEGF.
20062009
73,586
216,866
I
Investigator
Siu, Samuel C.;
Silversides, Candice
K.; Sermer, Mathew;
Colman, Jack M.;
Wald, Rachel M.;
Bruto, Venera C.
Cumulative Theme
$ to 2009
96
08-09 $
Keywords
08-09 $
Cumulative Theme
Investigator
Sugita, Shuzo
Toronto Western
Hospital
Roles for CAPS1 in loading,
storage and secretion
of catecholamines in
pheochromocytoma cells.
Noradrenaline, secretory
granules, storage, secretion,
CAPS1, pheochromocytoma.
20072009
64,500
129,000
I
Suskin, Neville
G.; Reid, Robert
D.; Prior, Peter L.;
Hachinski, Vladimir;
Chan, Richard K.T.;
Pipe, Andrew L.;
Sharma, Mukul
Lawson Health
Research Institute
Comprehensive cardiac
rehabilitation programming
for patients following transient
ischemic attack.
Cardiac rehabilitation,
transient ischemic attack.
20072009
126,745
253,331
II,III
Suuronen, Erik J.;
Ruel, Marc; Cao,
Xudong; DaSilva,
Jean N.; Beanlands,
Rob S.B.; de Kemp,
Robert A.; Harden,
James L.; Whitman,
Stewart C.; Veinot,
John P.; Li, Fengfu
University of
Ottawa Heart
Institute
Recruitment of endogenous
circulating progenitor cells for
cardiac regeneration using
acellular tissue-engineered
biomatrices.
Tissue engineering,
endothelial progenitor cells,
regenerative medicine, stem
cell therapy, coronary artery
disease.
20072009
94,333
183,431
I
Sweeney, Gary
York University
Direct effects of adiponectin on
cardiomyocytes.
Adiponectin, obesity, heart
failure, metabolism, diabetes.
20072010
70,250
152,565
I
Tang, Damu
McMaster
University
Characterization of a novel
insig binding protein
(INsigBP1).
Insig, insig binding protein,
sterol regulatory element
binding protein (SREBP),
SCAP (SREBP cleavage
activating protein),
cholesterol homeostasis.
20082011
81,500
81,500
I
Timmons, Brian W.
McMaster
University
A pilot study of circulating
progenitor cells in children
and adolescents: relationship
with habitual physical activity,
aerobic fitness and body
composition.
Circulating progenitor cells,
physical activity, fitness, body
composition.
20082009
32,134
32,134
I
Tobe, Sheldon W.;
Abbey, Susan E.;
Abramson, Beth
L.; Baker, Brian;
Irvine, Marilyn Jane;
Kiss, Alexander J.;
Myers, Martin G.
Sunnybrook
Health Sciences
Centre
Harmony study (Hypertension
analysis of stress reduction
using mindfulness meditation
and yoga).
Hypertension, relaxation
therapy, behaviour therapy,
lifestyle adjustment,
psychology.
20082011
75,627
75,627
II,III,IV
Touyz, Rhian M.
Ottawa Hospital
Research Institute
TRPM7 signaling through
lipid rafts in vascular smooth
muscle cells - implications in
hypertension.
Cation channels, magnesium,
signal transduction, vascular
remodeling, hypertension,
vascular biology.
20082011
108,905
108,905
I
Trigatti, Bernardo L.
McMaster
University
Molecular mechanisms
by which HDL contributes
to atherosclerotic plaque
regression.
Atherosclerosis, HDL,
regression, SR-BI, knockout.
20082010
99,750
99,750
I
Project
Term
$ to 2009
II: Clinical
97
Project
08-09 $
Cumulative Theme
Investigator
Truong, Kevin
University of
Toronto
Deciphering Ca2+ signaling
between subcellular organelles
using fluorescent protein
biosensors expressed in living
cells.
Calcium signaling, calcium
protein biosensors,
fluorescence resonance
energy transfer, live cell
imaging.
20072009
51,600
103,200
I
Tsushima, Robert
G.
York University
Cell signaling in myocardial
ischemic preconditioning.
Heart, ischemia, reperfusion,
cell signaling, transgenic
mice.
20082011
79,700
79,700
I
Tsushima, Robert
G.; Gaisano,
Herbert Y.
University of
Toronto
SNARE protein modulation of
cardiac Kv channels.
Potassium channels, calcium
channels, SNARE proteins,
SLMAP, electrophysiology.
20062009
80,925
238,369
I
Tuana, Balwant S.
University of
Ottawa
SLMAPs: sarcolemmal
membrane associated proteins
and E-C coupling.
Sarcoplasmic reticulum,
sarcolemma, membrane
targeting, coiled-coil, E-C
coupling.
20062010
142,667
423,478
I,II
Tyml, Karel
University of
Western Ontario
Hypoxia/reoxygenation,
systemic inflammation, and
vascular cell coupling.
Microcirculation, capillary,
enothelial cell, hypoxia and
reoxygenation.
20082010
79,346
79,346
I
Van Arsdell,
Glen S.; Li, Jia;
Redington, Andrew
N.
Hospital for Sick
Children
Analysis of the mechanism of
altered systemic and cerebral
oxygen transport in children
with hypoplastic left heart
syndrome undergoing stage I
palliation.
Oxygen transport, Norwood
procedure, hypoplastic
left heart syndrome,
postoperative management,
brain oxygenation.
20062009
89,328
264,428
II
Van Arsdell,
Glen S.; Li, Jia;
Guerguerian,
Anne-Marie;
Dennis, Maureen F.;
Laughlin, Suzanne;
Otsubo, Hiroshi
Hospital for Sick
Children
The influence of postoperative
systemic oxygen transport on
neurologic outcomes in infants
undergoing the Norwood
procedure with a modified
Blalock-Taussing shunt or a
right ventricle-to-pulmonary
artery shunt.
Oxygen transport, neurologic
outcomes, Norwood
procedure, postoperative
management.
20072009
59,150
118,150
II
Van Arsdell, Glen
S.; Riazi, Ali. M.
Hospital for Sick
Children
Selective generation of
cardiac progenitor cells and
cardiomyocytes from mouse
stem cells.
Stem cells, transplantation,
cardiac progenitor cells.
20082010
67,340
67,340
I
Van Huysse, James
W.
University of
Ottawa Heart
Institute
Roles of the brain Na,
K-ATPase alpha isoforms in the
regulation of blood pressure.
Hypertension, Na, K-ATPase,
renin-angiotension system,
CNS, ouabain-like substance.
20082011
76,949
76,949
I
Verma, Subodh;
Stewart, Duncan J.;
Oudit, Gavin Y.
St. Michael's
Hospital
ACE2: novel regulator of
endothelial function and
atherosclerosis.
Endothelial function,
atherosclerosis, angiotensin,
mice, vascular function.
20072010
105,809
209,867
I
von Harsdorf,
Rudiger
Toronto General
Research Institute
Evaluation of p21CIP1/WAF1
protein transduction as a novel
therapeutic approach in heart
failure.
Cardiomyocytes, myocardial
infarction, hypertrophy,
apoptosis, P21CIP1.
20082011
80,000
80,000
I
$ to 2009
98
Keywords
Term
Keywords
08-09 $
Cumulative Theme
Investigator
Waddell, Thomas
K.
Toronto General
Hospital
The role of galectin-3 in
xenograft rejection.
Transplantation,
xenotransplantation, lectins,
coagulation, inflammation.
20072010
91,950
181,489
I
Walley, Keith R.;
Murkin, John M.
St. Paul's Hospital
neurocognitive dysfunction
following cardiopulmonary
bypass.
Cardiopulmonary bypass,
genes, polymorphism,
cognitive dysfunction.
20082011
85,328
85,328
I,II
Wang, Hao
University of
Western Ontario
Soluble CD83 based therapy in
cardiac allograft tolerance.
Heart transplantation, soluble
CD83, tolerance, dendritic
cells, T regulatory cells.
20082011
79,967
79,967
I
Wang, Hui Di
Brock University
Reactive oxygen species
mediates angiotensin II
induced ET-1 release from
vascular adventitial fibroblasts.
Adventitia, angiotensin
II, ET-1, oxidative stress,
signaling pathway.
20072009
57,010
113,510
I
Ward, Christopher
A.; Ogunyankin,
Kofo O.; Melo, Luis
Gabriel
Queen's University
Cell-based gene therapy
strategy to enhance
neovascularization and healing
of infarcted myocardium.
Endothelial progenitor
cells, mesenchymal stem
cells, genetic engineering,
myocardial infarction,
neovascularization.
20072009
92,952
190,180
I
Warkentin,
Theodore E.
McMaster
University
Heparin-induced
thrombocytopenia.
Platelet, heparin, igG,
thrombocytopenia,
thrombosis.
20072010
101,854
201,748
I,II
Weisel, Richard D.;
Fazel, Shafie
Toronto General
Hospital
Cardiac regeneration by cell
transplantation.
Myocardial infarction,
ventricular remodeling,
cardiac regeneration, matrix
remodeling, angiogenesis.
20062009
72,075
212,216
I
Weisel, Richard D.;
Fazel, Shafie
Toronto General
Hospital
Cardiac regeneration:
improving the response to
injury.
Myocardial infarction, cardiac
remodeling, angiogenesis,
matrix remodeling, recruit
precursor cells, bone marrow
response.
20072010
77,182
150,784
I
Weitz, Jeffrey I.
McMaster
University
Mechanisms of coronary
catheter-induced clotting.
Percutaneous coronary
interventions, thrombosis,
contact pathway
anticoagulants.
20062010
116,670
344,168
I
Weitz, Jeffrey I.
McMaster
University
Impact of gamma' fibrinogen
on clot formation and clot lysis
at sites of plaque rupture.
Coagulation, fibrinolysis,
anticoagulants, plasminogen
activators, thrombolysis.
20082013
126,811
126,811
I
Wells, James W.
University of
Toronto
Nature of the signalling
complex between cardiac
muscarinic receptors and G
proteins.
Heart disease, muscarinic
cholinergic receptor, G
protein, co-operativity,
oligomers, signalling
mechanism.
20082011
80,830
80,830
I
Project
Term
$ to 2009
II: Clinical
99
Project
08-09 $
Cumulative Theme
Investigator
Wells, Philip S.;
Anderson, David
R.; Kearon, Clive;
Kovacs, Michael
J.; Crowther, Mark
A.; Rodger, Marc
A.; Kahn, Susan R.;
Carson, Nancy L.;
Ramsay, Timothy O.
Ottawa Hospital
Research Institute
Development and validation
of clinical prediction rules
for bleeding for patients on
anticoagulant therapy for
venous thromboembolism.
Bleeding risk,
prediction rules, venous
thromboembolism, oral
anticoagulants, singlenucleotide polymorphisms.
20082013
195,550
195,550
I,II,IV
Wells, R. Glenn; de
Kemp, Robert A.;
Ruddy, Terrence D.
University of
Ottawa Heart
Institute
Increasing certainty in
micro-SPECT/CT.
SPECT (Single photon
emission computed
tomography), CT, uncertainty,
anatomical priors,
small-animal imaging.
20082010
78,555
78,555
I
Wen, Xiao-Yan; Ni,
Heyu
University Health
Network
Investigation of lysophospatidic
acid (LPA) generation and
platelet function in newly
developed lpdlr phospholipase
deficient mice.
Phospholipase A1, gene
targeting, thrombosis,
lysophosphatidic acid,
platelet.
20072009
87,232
178,441
I
Werstuck, Geoffrey
H.
McMaster
University
Investigating the role of
glycogen synthase kinase
(GSK)-3 in atherogenesis.
Atherosclerosis, glycogen
synthase kinase (GSK)-3, ER
stress, diabetes mellitus,
hyperhomocysteinemia.
20072010
82,688
166,940
I
White, James A.;
Drangova, Maria;
Siu, Samuel C.;
Wisenberg, Gerald;
Yee, Raymond
London Health
Sciences Centre
Multi-modality imaging
assessment for pacing
interventions in heart failure
(MAPIT-HF).
Cardiac resynchronization,
imaging, MRI, CT, tissue
doppler.
20082011
103,338
103,338
II
Whitman, Stewart
C.
University of
Ottawa Heart
Institute
The role of the innate immune
system in atherosclerosis:
Further defining the role of
NKT cells, interferon-gamma
and IL-4 in the disease process.
Atherosclerosis, LDLr -/- mice,
laser capture microdissection,
microarray analysis, histology.
20082011
98,800
98,800
I
Wijeysundera,
Duminda N.;
Beattie, William
S.; Rubin, Barry B.;
Badner, Neal H.;
Delgado, Diego H.;
Choi, Peter T.L.
University Health
Network
The EPIC (evaluating
perioperative ischemia
reduction by clonidine) study:
a randomized, triple-blinded,
placebo-controlled trial of
combining clonidine with
chronic beta-blockade in
intermediate-to-high risk
non-cardiac surgery.
Clinical trials, perioperative
medicine, coronary
artery disease, clonidine,
anesthesia.
20072009
40,085
169,128
II
Wiper-Bergeron,
Nadine L.
University of
Ottawa
The inhibition of adipocyte
differentiation by retinoic
acid: A role for C/EBPbeta
displacement.
20082010
71,468
71,468
I
$ to 2009
100
Keywords
Term
Project
Keywords
Term
London Health
Sciences Centre
Evaluation in a large animal
model of the use of Akt
enhanced endothelial
progenitor cells for
augmenting healing after
Myocardial infarction, stem
cell delivery, magnetic
resonance imaging,
myocardial remodelling,
SPECT imaging.
20082010
78,883
78,883
I
Yang, Burton B.
Sunnybrook
Health Sciences
Centre
Roles of miR-17-5p in
endothelial wound healing and
angiogenesis.
Extracellular matrix,
proliferation, adhesion,
molecular biology, cell
biology, angiogenesis,
microRNA.
20082011
82,060
82,060
I
Yang, Kaiping;
Arany, Edith J.R.;
Hill, David J.
University of
Western Ontario
Early-life origins of visceral
adiposity.
Maternal nutrition, visceral
adiposity, adipogenesis,
mechanisms, animal models.
20072009
85,192
167,113
I
Yao, Zemin
University of
Ottawa Heart
Institute
Interrelationship between
hepatic lipase expression,
proinflammatory cytokines, and
HDL metabolism.
Hepatic lipase, HDL, cytokine,
hypoalphalipoproteinemia,
inflammation.
20072010
86,360
171,039
I
Yao, Zemin
University of
Ottawa Heart
Institute
Analysis of non-truncation
apoB mutations associated
with human familial
hypobetalipoproteinemia.
Hypobetalipoproteinemia,
apoB, VLDL assembly, cell
culture, adenovirus.
20072010
82,538
163,458
I
Yee, Raymond; Siu,
Samuel C.
London Health
Sciences Centre
His bundle and para-hisian
pacing: Acute and chronic
benefits.
His bundle, pacing, LV
dyssynchrony.
20082010
74,819
74,819
II
Yeung, Rae S.M.
Hospital for Sick
Children
Towards a better
understanding of Kawasaki
disease.
Kawasaki disease,
inflammation, T-cells, animal
model, autoimmunity.
20082011
79,725
79,725
I,II
Zandstra, Peter W.;
Husain, Mansoor;
Nanthakumar,
Kumaraswamy
University of
Toronto
Controlling bioreactor
conditions to optimize
regenerative potential of
cardiomyocytes.
Bioengineering,
cardiomyocyte
transplantation, regenerative
medicine, stem cell
differentiation.
20072009
89,725
177,575
I
Zha, Xiaohui
Ottawa Hospital
Research Institute
Signal transduction pathways
that regulate ABCA1-mediated
cholesterol efflux.
ABCA1, cholesterol,
HDL,apoA-I and microscopy.
20082010
74,300
74,300
I
Zhang, Shetuan
Queen's University
of drug-induced long QT
syndrome and sudden cardiac
death.
Myocardium,
emergency cardiac care,
electrophysiology, molecular
biological techniques, cardiac
dysrrhythmias.
20062009
36,000
108,000
I
Zhang, Wandong;
Zhang, Xia; Woulfe,
John M.
University of
Ottawa
Modulation of MMP9
expression induced by cerebral
ischemia and reperfusion to
reduce blood-brain barrier
permeability and brain damage
in ischemic stroke.
Stroke, ischemia/reperfusion,
MMP9 expression, BBB
permeability, brain damage.
20082011
56,000
56,000
I
Investigator
Wisenberg, Gerald;
Prato, Frank S.;
Feng, Qingping
08-09 $
Cumulative Theme
$ to 2009
II: Clinical
101
Project
Keywords
Term
University of
Ottawa
Poststroke treatment with
cannabinoids for promoting
neural regeneration.
Ischemia, marijuana,
neurogenesis, hippocampus,
functional recovery.
20062009
59,670
176,670
I
Zhang, Zhu-Xu;
Zhong, Robert;
Min, Wei-Ping
London Health
Sciences Centre
Therapeutic potential and
mechanism of double-negative
regulatory T (DN-Treg) cells
mediated tolerance in heart
transplantation.
Mixed chimerism,
transplantation, double
negative T cell, regulatory T
cell, tolerance.
20072009
78,294
156,588
I
Zimmerman,
Deborah L.;
Hébert, Paul C.;
Burns, Kevin D.;
Fergusson, Dean
A.; Ruzicka, Marcel
Ottawa Hospital
Research Institute
Control of hypertension in
end stage renal disease, a
randomized cross-over study
comparing daily hemofiltration
to conventional hemodialysis.
Hypertension, hemofiltration,
hemodialysis, ambulatory
monitoring, bioimpedance.
20072009
53,327
109,652
II
Investigator
Zhang, Xia
08-09 $
Cumulative Theme
$ to 2009
Québec
Project
Investigator
Agharazii, Mohsen
Hôtel-Dieu de
Québec
Determinants of progression
of human aortic stiffness in
renal failure: role of advanced
glycation end products,
oxidative stress, endotheline-1
and inflammation.
Arterial stiffness, advanced
glycation end-products,
oxidative stress,
inflammation, renal failure.
20062009
17,000
45,200
I,II
Athale, Uma
H.; Laverdière,
Caroline;
Silverman, Lewis
B; Chan, Anthony
K.C.; Thabane,
Lehana
McMaster
University
Evaluation for inherited and
acquired prothrombotic defects
predisposing to symptomatic
thromboembolism in children
with acute lymphoblastic
leukemia.
Acute lymphoblastic
leukemia, thromboembolism,
prothrombotic disorder,
chemotherapy, children.
20072009
7,571
14,791
II
Bachelard, Hélène
Centre hospitalier
de l'Université
Laval
Role of endothelial NO
in vascular and metabolic
dysfunctions induced by a high
fat high sucrose diet.
Dietary aquired insulin
resistance, vascular
endothelium dysfunction,
NO, oxidative stress,
TNF-alpha.
20072010
11,000
21,000 I,II,III,IV
Baroudi, Ghayath
Hôpital du SacréCœur de Montréal
Regulation of the unapposed
connexin 43 hemichannels:
implicated in cardioprotection
against ischema/reperfusion
injury.
Connexin 43 hemichannels,
protein kinase C isoforms,
connexin-mimetic peptides,
patch clamp.
20072010
23,000
43,000
Term
Cumulative $
Theme
to 2009
102
Keywords
08-09 $
I
Investigator
Beanlands, Rob
S.B.; Nichol,
Graham; Freeman,
Michael R.; Ruddy,
Terrence D.;
Hendry, Paul J.;
Racine, Normand
University of
Ottawa Heart
Institute
PET and recovery following
revascularization (PARR):
evaluation of outcome and
cost-effectiveness using an
FDG PET-guided approach to
management of patients with
coronary disease and severe LV
dysfunction. PARR phase 2.
Myocardial viability,
LV dysfunction and heart
failure, revascularization,
glucose metabolism, positron
emission tomography.
20072010
11,000
21,000
II
Billette, Jacques
Université de
Montréal
Role of dual pathways in ratedependent AV nodal function.
Electrophysiology, AV
node, dual pathways, ratedependency, supraventricular
tachyarrhythmias.
20072010
17,000
31,500
I
Bkaily, Ghassan
Université de
Sherbrooke
Modulation of nuclear calcium
cycling by ET-1 in heart cells.
Nucleus, endothelin-1,
pharmacology, calcium,
heart.
20082011
17,000
17,000
I
Blostein, Mark D.
Lady Davis
Institute for
Medical Research
Physiology of gas6-Ax1
interactions in endothelial cells.
Ax1, gas6, endothelium,
apoptosis, gammacarboxylation.
20062009
17,000
45,200
I
Bossé, Yohan;
Pibarot, Philippe;
Mathieu, Patrick
Laval Hospital
Research Center
(CRHL)
Genetic susceptibility to calcific
aortic valve stenosis.
Aortic stenosis, candidate
genes, genomics, microarray,
genotyping.
20082011
17,000
17,000
I,II
Boulay, Guylain
Université de
Sherbrooke
Roles des canaux TRPCs
dans les cellules du systeme
cardiovasculaire.
TRPC, signalisation,
phosphorylation, calcium,
muscle lisse, biologie
moléculaire.
20062009
23,000
61,000
I
Bouvier, Michel
Université de
Montréal
Receptors, regulation, postcontrolling the signaling efficacy translational modification,
and selectivity of dynamic
signaling efficacy, G-proteins.
G protein-coupled receptor
signaling complexes.
20062009
23,000
61,000
I
Brissette, Louise
Université
du Québec à
Montréal
Oxidized LDL metabolism.
Lipoprotein, oxidation,
cholesterol, SR-BI, CD36.
20062009
23,000
61,000
I
Brochu, Michèle
Hôpital SainteJustine
Investigation of cardiomyocyte
remodeling during pregnancy.
Cardiac myocyte, Na pump,
pregnancy, remodeling,
hypertension, patch clamp,
confocal microscopy, TCSPC,
fluorescent imaging, LV
hypertrophy.
20082010
11,000
21,000 I,II,III,IV
Calderone,
Angelino
Montreal Heart
Institute
Neural stem cells and scar
remodelling.
Reparative fibrosis,
myofibroblasts, ANP,
sympathetic system,
transgenics.
20062009
17,000
45,200
I
Carpentier, André
C.; Fulop, Tamas
Université de
Sherbrooke
Postprandial plasma free fatty
acid metabolism and the innate
and adaptive immune system in
the metabolic syndrome.
Postprandial lipid
metabolism, free fatty
acid, insulin resistance,
inflammation, lymphocytes,
immune response.
20072010
17,000
31,500
I,II
Project
Keywords
Term
08-09 $
Cumulative $
Theme
to 2009
II: Clinical
103
Investigator
Project
Keywords
Term
08-09 $
Cumulative $
Theme
to 2009
Chahine, Mohamed Hôpital Laval
Le canal sodique cardiaque et
son role dans la génèse des
troubles du rythme.
Canal sodique, Nav1.5,
cœur, arythmie, syndrome
de Brugada, fibrillation
ventriculaire, patch clamp.
20062009
23,000
61,000
I
Chalifour, Lorraine
E.; Sebag, Oga
Jewish General
Hospital
The role of gender-dependent
differences in calcium
homeostasis protein expression
in dictating the response to
catecholamine stress.
Gender, calcium homeostasis
proteins, gene expression,
catecholamine, cardiac
physiology.
20062009
23,000
61,000
I
Claing, Audrey
Université de
Montréal
Regulation of G proteincoupled receptor function by
ARF6.
G protein-coupled receptor,
endothelial and vascular
smooth muscle cells, small
GTPases, endocytosis, cell
migration.
20062009
17,000
45,200
I
Cooper, Ellis J.
McGill University
Effects of elevations in cytosolic
reactive oxygen species
postsynaptically on synaptic
transmission in sympathetic
ganglia.
Reactive oxygen species,
nicotinic acetylcholine
receptors, sympathetic
neurons, sympathetic
ganglia, synaptic
transmission.
20072010
23,000
43,000
I
Couet, Jacques;
Marie Arsenault
Institut de
cardiologie de
Québec
Aortic valve stenosis in small
animal models.
Heart valve diseases, aortic
stenosis, atherosclerosis,
metabolic syndrome, animal
models.
20062009
17,000
45,200
I
Couture, Réjean
Université de
Montréal
Kinin receptors in diabetes and
hypertension.
Neuropeptides, autonomic
nervous system, CNS,
diabetes, hypertension.
20062009
17,000
45,200
I
Daleau, Pascal
Institut de
cardiologie de
Québec
Comportement des connexons
non-appariés lors de l'ischémie.
Hémi-jonctions gap,
patch-clamp, tranfection
cellulaire, ischémie, arytmies.
20072010
17,000
31,500
I
de Kemp, Robert
A.; Bentourkia,
M'hamed M.B.;
Lecomte, Roger
University of
Ottawa Heart
Institute
Quantitative molecular PET
imaging in mouse models of
heart disease.
20062009
17,000
45,200
I
Denault, André
Y.; Tardif, JeanClaude; Perrault,
Louis P.; Varin,
France; Lambert,
Jean
Institut de
cardiologie de
Montréal
Inhaled milrinone
facilitates separation from
cardiopulmonary bypass.
Cardiac surgery,
transesophageal
echocardiography, pulmonary
hypertension.
20072009
23,000
43,000
II
Drolet, Benoit
Hôpital Laval
The possible role of diabetes
in drug-induced cardiac
proarrhythmia.
Electrophysiology,
diabetes, patch-clamp,
action potentials, ECG,
QT-prolonging drugs.
20062009
23,000
61,000
I
Drolet, Guy;
Mouginot, Didier
M.
Centre de
Recherche du
CHUL (CHUQ)
Opioid regulation of salt intake.
Electrophysiology, functional
neuroanatomy, ingestive
behavior, patch-clamp, saltsensitive hypertension.
20072010
23,000
43,000
I
104
Investigator
Eisenberg, Mark
J.; Tyndale, Rachel
F.; Filion, Kristian
B.; Gervais,
André J. G.;
Joseph, Lawrence;
O'Loughlin,
Jennifer Lee;
Paradis, Gilles;
Pilote, Louise;
Rinfret, Stéphane
Jewish General
Hospital
Pharmacogenetic and
pharmacokinetic variation in
CYP2B6 and the efficacy of
Zyban as a smoking cessation
aid: a Zesca trial sub-study.
Smoking cessation,
epidemiology, genetics,
clinical trials, acute coronary
syndrome
20072010
17,000
31,500
II
Filep, Janos
Hôpital
MaisonneuveRosemont
Inhibition of C-reactive proteinmediated inflammation by
aspirin-triggered lipoxins.
C-reactive protein,
inflammation, leukocyte,
aspirin-triggered lipoxins,
acute coronary syndromes.
20062009
17,000
45,200
I
Fiset, Céline
Institut de
cardiologie de
Montréal
Mechanisms underlying cardiac K+ channels, cardiac
arrhythmia in transgenic models electrophysiology, transgenic
of hypertrophy and heart failure. mouse, mouse heart, cardiac
repolarization.
20082011
23,000
23,000
I
Genest, Jacques;
Marcil, Michel;
Rashid, Shirya
Royal Victoria
Hospital
HDL genetics: the molecular
cellular physiology of
cholesterol efflux defect not
caused by ABCA1 mutations.
20062009
18,000
54,000
I,II
Glavinovic, Mladen
I.
McGill University
Dynamics of catecholamine
Catecholamine secretion,
release and release of vesicular electrophysiology, parameter
content in neuroendocrine cells. estimation, molecular
dynamics, electro-osmotic
and nano-fluidic simulations.
20062009
17,000
45,200
I
Gobeil, Fernand
Université de
Sherbrooke
Novel localization of nuclear
kinin B2 receptors and
functional correlates.
20062009
17,000
45,200
I
Greenwood,
Michael T.
McGill University
Characterization of the antiapoptotic properties of novel
cardiac suppressors of Bax
mediated cell death.
Anti-apoptosis, Bax
suppressors, yeast genetics,
cultured cardiomyocytes.
20072010
17,000
31,500
I
Guillemette,
Gaétan
Université de
Sherbrooke
Étude des IP3Rs dans
l'endothélium.
Endothélium, calcium,
mTOR, calcineurine, inositol
1,4,5-trisphosphate.
20082011
23,000
23,000
I
Gutkowska,
Jolanta; Jankowski,
Marek; Coderre,
Lise
Centre Hospitalier
de l'Université de
Montréal
Role of the insulin regulated
Insulin regulated
aminopeptidase (oxytocinase) in aminopeptidase, insulin
the heart.
action, pregancy, natriuretic
peptides.
20062009
23,000
61,000
I
Hébert, Terence E.
McGill University
Composition, ontogeny and
biosynthesis of specific GPCR
signalling complexes.
20082011
23,000
23,000
I
Project
Keywords
Term
08-09 $
Cumulative $
Theme
to 2009
II: Clinical
Cholesterol, high density
lipoproteins, ATP binding
cassette AI (ABCA1),
apolipoprotein AI, cellular
cholesterol transport.
Signalling, G proteins,
organization, heart failure,
adrenergic receptors.
105
Project
Investigator
Huot, Jacques
Hôtel-Dieu de
Québec
Role of stress-sensitive pathways Oxidative stress, VEGF,
in regulating endothelial cell
endothelial cells, signaling,
activation and functions.
angiogenesis.
20082011
23,000
23,000
I,II
Hussain, Sabah
N.A.
Royal Victoria
Hospital
Roles of nox proteins in
angiopoietin/tie-2 signaling.
Angiogenesis, endothelial
cells, NAPHD oxidase, nox4,
nox2, oxygen radicals.
20082011
23,000
23,000
I
Jacques, Danielle
Université de
Sherbrooke
Regulation of cytosolic and
nuclear calcium by angiotensin
II in endocardial endothelial
cells.
Angiotensin II, receptors,
intracellular calcium, confocal
microscopy, hypertrophy.
20072010
17,000
31,500
I
Joanette, Yves; Ska, Institut
Bernadette
universitaire
de gériatrie de
Montréal
Towards distinct clinical profiles
of communication impairments
after a right-hemisphere stroke.
Stroke, communication
impairments, right
hemisphere, evaluation
subtypes.
20072010
17,000
31,500
II
Julien, Pierre;
Bilodeau, JeanFrancois; Fraser,
William C.
Centre de
recherche du
CHUL
Oxidative stress in
preeclampsia: neuroprostanes
and endothelial dysfunction.
Oxidative, preeclampsia,
fatty acids, neuroprostanes,
lipoprotein.
20072009
11,000
21,000
I
Langlois, MarieFrance
Université de
Sherbrooke
Study of the role of GRP1
in PPAR-gamma-mediated
transcription and regulation of
adipogenesis.
Nuclear receptors,
PPAR-gamma, GRP1,
transcriptional regulation,
adipogenesis.
20082011
17,000
17,000
I
Larivière, Richard
Hôtel-Dieu de
Québec
Role of TGF-beta 1 in vascular
endothelial dysfunction.
Hypertension, renal failure,
endothelium, blood vessels,
vasoactive factors.
20062009
17,000
45,200
I
Larose, Éric;
Bertrand, Olivier F;
Pibarot, Philippe;
Poirier, Paul;
Després, JeanPierre
Hôpital Laval
Is vulnerable atherosclerosis a
local or systemic phenomenon?
Atherosclerosis, metabolic
risk, cerebrovascularcardiovascular interaction,
risk stratification.
20082010
17,000
17,000
I,II,IV
Lavoie, Kim L.;
Bacon, Simon L;
Arsenault, André;
Blais, Lucie;
Dupuis, Jocelyn;
Ditto, Blaine
Université
du Québec à
Montréal
CAD risk associated with clinical
vs subclinical depression.
Depression, CAD, survival,
cardiac events, follow-up.
20072010
23,000
43,000
II,III,IV
Lavoie, Julie L.
Centre hospitalier
de l'Université de
Montréal
Role of the tissue-specific
renin-angiotensin system in
adipose tissue in obesity and
obesity-related hypertension.
Obesity, obesity-related
hypertension, reninangiotensin systeme, adipose
tissue.
20082011
17,000
17,000
I
Leduc, Richard;
Lavigne, Pierre;
Escher, Emmanuel;
Klarskov, Klaus
Université de
Sherbrooke
urotensin II.
20062009
17,000
45,200
I
Term
Cumulative $
Theme
to 2009
106
Keywords
08-09 $
Investigator
Lerouge, Sophie;
Soulez, Gilles ;
Hebert, MarieJosee
Hôpital NôtreDame
Bioactive coatings to counter
VSMC depletion and promote
healing: towards a new
generation stent-graft for
endovascular aneurysm repair.
Aneurysm, endovascular
treatment, bioactive
coating, chondroitin sulfate,
apoptosis.
20072010
23,000
43,000
I
Lesur, Olivier;
Lecomte, Roger;
Bentourkia,
M'hamed M.B.
Université de
Sherbrooke
Impact of fluid resuscitation
on endotoxin-induced heart
dysfunction.
Septic shock, myocardial
dysfunction, PET scan
imaging, myocardial
apoptosis, fluid resuscitation.
20062009
23,000
61,000
I
Levin, Mindy F.;
Sveistrup, Heidi;
Ptito, Alain
McGill University
Optimizing arm motor recovery
in stroke.
Rehabilitaion, recovery,
stroke, virtual reality, exercise.
20072010
23,000
43,000
I,II,III
Ly, Hung Q.
Montreal Heart
Institute
Homing and engraftment of
stem cells: implications for
cardiac repair and regeneration
in the setting of ischemic heart
diseases.
Stem cells, heart, homing,
engraftment, translational
research.
20082011
17,000
17,000
I
Magder, Sheldon
A.
McGill University
Role of vascular vs phagocytic
NAD(P)H oxidase in the septic
response.
Sepsis, reactive oxygen
species, microcirculation
inflammation, lung injury,
NFkB.
20062009
23,000
61,000
I
Marelli, Ariane
J.; Pilote, Louise;
Abrahamowicz,
Michael; Khairy,
Paul; Mackie,
Andrew S.;
Therrien, Judith
Royal Victoria
Hospital
A population-based analysis of
changing survival of patients
with congenital heart disease.
Adults, congenital, heart
defects, epidemiology,
population study.
20082011
17,000
17,000
III,IV
Marleau, Sylvie;
Ong, Huy;
Lamontagne,
Daniel
Université de
Montréal
CD36 ligands, a new
therapeutic avenue for ischemic
cardiopathies?
Growth hormone-releasing
peptides, myocardial
ischemia-reperfusion, CD36,
oxidative stress, leukocyte
trafficking.
20072010
11,000
21,000
I
Moreau, Pierre
Université de
Montréal
Mechanisms of mineral loss
in medial elastocalcinosis
(medial arterial calcification):
a therapeutic opportunity for
isolated systolic hypertension.
Endothelin, elastocalcinosis,
aortic stiffness, extracellular
matrix.
20062009
23,000
61,000
I
Mouginot, Didier
M.
Centre hospitalier
de l'Université
Laval
Central regulation of sodium
homeostasis.
Hypothalamus, hydromineral
balance, angiotensin 2,
patch-clam, salt-induced
hypertension.
20072010
23,000
43,000
I
Mounier, Catherine
Université
du Québec à
Montréal
Hormonal regulation of the
stearoyl CoA desaturase 1 gene
expression: key role in obesity
development.
Stearyl CoA desaturase 1,
insulin, leptin, adipogenesis,
obesity.
20072010
17,000
31,500
I
Project
Keywords
Term
08-09 $
Cumulative $
Theme
to 2009
II: Clinical
107
Investigator
Project
MukaddamDaher, Suhayla;
Gutkowska, Jolanta
Centre hospitalier
de l'Université de
Montréal
Effects of sympathetic inhibition
in cardiac pathologies.
Nattel, Stanley
Montreal Heart
Institute
Nigam, Anil; Roy,
Denis; Talajic,
Mario; Nattel,
Stanley; Tardif,
Jean-Claude;
Lambert, Jean;
Keywords
Term
08-09 $
Cumulative $
Theme
to 2009
Apoptosis, beta adrenenergic
blockers, cardiac pathology,
imidazoline receptors, in vivo,
in vitro.
20082011
17,000
17,000
I
Factors influencing the
interaction of antiarrhythmic
drugs with cardiac tissues:
mechanisms and consequesces
of artial ionic remodeling.
20072010
23,000
43,000
I
Montreal Heart
Institute
Randomized trial of the effect of Omega-3 fatty acids, atrial
long-chain n-3 polyunsaturated fibrillation, inflammation,
fatty acids on arrhythmia
oxidative stress, arrhytmias.
recurrence in atrial fibrillation.
20072010
17,000
31,500
II,III
Noiseux, Nicolas
Centre hospitalier
de l'Université de
Montréal
Angiogenic and paracrine
effects of bone marrow-derived
mesenchymal stem cells for
the treatment of myocardial
infarction.
Adult stem cells, myocardial
infarction, cardiac repair,
angiogenesis, paracrine.
20062009
17,000
45,200
I
Nuyt, Anne
Monique
CHU SainteJustine
Is perinatal oxidative stress the
common pathway underlying
developmental programming of
hypertension?
Hypertension, programming,
oxidant, vascular, brain.
20072010
23,000
43,000 I,II,III,IV
Orlov, Sergei N.;
Tremblay, Johanne;
Hamet, Pavel
Centre hospitalier
de l'Université de
Montréal
Endogenous cariotonic steroids: Cardiotonic steroids,
role in endothelial dysfunction
Na+, K+-pump, vascular
and vascular remodeling.
remodelling.
20072010
17,000
31,500
I
Pagé, Pierre
Neurogenic substrates of atrial
fibrillation.
Autonomic nervous
system, atrial fibrillation,
electrophysiologic cardiac
mapping, coronary artery
bypass grafting, extracellular
neuronal recording.
20072010
23,000
43,000
I
Parent, Lucie
Université de
Montréal
Molecular studies of the
cardiovascular L-type Ca
channel in health and in
disease.
Calcium, electrophysiology,
gating, structure, molecular
biology.
20082011
23,000
23,000
I
Pharand, Chantal;
Diodati, Jean G.;
Amyot, Robert
Determinants of subendocardial Subendocardial ischemia,
ischemia at normal heart rate in myocardial perfusion,
a porcine model.
myocardial contrast
echocardiography, porcine
model, platelet mediators.
20062009
17,000
45,200
I
Jones, Peter J.H.
108
Investigator
Pilote, Louise;
Karp, Igor;
Bacon, Simon L;
Chalifour, Lorraine
E.; Cox, Jafna L.;
Dasgupta, Kaberi;
Daskalopoulou,
Styliani-Stella;
Eisenberg, Mark
J.; Engert , James
C.; Ghali, William
A.; Hamet, Pavel;
Humphries, Karin
H.; Khan, Nadia
A.; Lavoie, Kim L.;
Norris, Colleen
M.; Rabi, Doreen
M.; Stark, Ken D.;
Tagalakis, Vicky;
Tremblay, André;
Tu, Jack V.
McGill University
syndrome.
20082011
17,000
17,000
II,III,IV
Pirabot, Philippe;
Després, JeanPierre; Dumesnil,
Jean G.; Mathieu,
Patrick
Hôpital Laval
Metabolic determinants of the
progression of aortic stenosis.
Valvular heart diseases,
aortic stenosis, metabolism,
metabolic syndrome,
doppler-echocardiography.
20062009
23,000
61,000
I,II
Powell, William S.
McGill University
Eicosanoids and leukocyte and
endothelial cell function.
20062009
23,000
61,000
I
Richard, Darren E.
Hôtel-Dieu de
Québec
Role of HIF-1 induction in the
vasculature.
HIF, hypoxia, smooth muscle,
angiotensin, cell signaling.
20082011
23,000
23,000
I
Rousseau, Guy
Cardioprotective role of
omega-3 fatty acids in
reperfused myocardial
infarction.
Myocardial infarction,
reperfusion, Omega-3,
inflammation, neutrophils.
20072010
17,000
31,500
I
Sauvé, Remy
Université de
Montréal
Molecular studies of the calcium
activated KCa3.1 channel
expressed in endothelial cells.
20082011
23,000
23,000
I
Servant, Marc
Université de
Montréal
Roles of interferon regulatory
factors-3 and NF-kB
transcription factors in the
induction of pro-atherosclerotic
conditions by classical as well as
emerging risk factors.
Inflammation, angiotensin
II, pathogens, NF-kB,
interferon-regulatory
factors, signal transduction
mechanisms.
20062009
17,000
45,200
I
Shrier, Alvin; Glass,
Leon
McGill University
Dynamics and remodeling of
cultured cardiac cells.
Tissue culture, optical
mapping, cardiac
electrophysiology, nonlinear
mathematics, pacing.
20062009
17,000
45,200
I
Project
Keywords
Term
08-09 $
Cumulative $
Theme
to 2009
II: Clinical
109
Project
Investigator
Sirois, Martin G.
Montreal Heart
Institute
Agonistic activities of
angiopoietins on neutrophils.
Angiopoietins, Tie2 receptor,
neutrophils, cell signaling,
inflammation.
20062009
23,000
61,000
I
St-Amand, Jonny
Laval University
Medical Center
(CHUL)
Characterization of two novel
signals regulating dietary fat
intake.
Coronary artery diseases,
obesity, dietary fat intake,
gene discoveries, protein
injection.
20082011
17,000
17,000
I
St-Louis, Jean
CHU SainteJustine
Régulation du tonus vasculaire:
prostanoïdes et monoxyde
d'azote.
Tissulaire, organes isolés,
pharmacologie, obstétrique.
20072010
17,000
31,500
I,II
Stochaj, Ursula
McGill University
Protein trafficking in stressed
cells.
Oxidative stress, 5-AMPactivated kinase (AMPK),
nuclear transport, ischemia/
reperfusion.
20082011
17,000
17,000
I
Tanguay, JeanFrançois; Cloutier,
Isabelle A.
Montreal Heart
Institute
Study of vascular smooth
muscle cells regulation by
adipocytes in a mouse model of
diet-induced diabetes.
Vascular, smooth muscle
cell, adipocyte, diabetes,
atherosclerosis.
20072010
11,000
21,000
I
Thorin, Eric;
Ferland, Guylaine;
Hamel, Edith
Montreal Heart
Institute
Mechanisms and cognitive
consequences of
cerebrovascular dysfunction in
aging and dyslipidemia.
Cerebrovascular dysfunction,
aging, dysplidemia, cerebral
blood flow, cognitive
impairment.
20062009
17,000
45,200
I
Turgeon, Jacques
Centre hospitalier
de l'Université de
Montréal
The expression of drug influx/
efflux transporters in the heart:
a new paradigm for intersubject
variability in cardiac drug
actions.
Electrophysiology,
drug-induced long
QT-syndrome, transporters,
proarrhythmias, drug
interactions.
20082011
23,000
23,000
I
Vidal, Silvia M.
McGill University
Molecular genetics of host
susceptibility to cardiovirulent
coxsakievirus infection.
Antiviral immunity, complex
trait analysis, coxsakievirus
(Enterovirus) infection,
models of infection, mouse
genetics.
20082011
17,000
17,000 I,II,III,IV
Wang, Zhiguo
Montreal Heart
Institute
A signature pattern of stressresponsive microRNAs that can
induce cellular injuries during
miRNA, gene expression,
arrhythmias, cell death.
20082011
23,000
23,000
I
Wu, Jiangping
Centre hospitalier
de l'Université de
Montréal
Immune regulation in heart
transplantation.
Drak2, transplantation,
chronic rejection, kinase.
20082011
23,000
23,000
I
Term
Cumulative $
Theme
to 2009
110
Keywords
08-09 $
New Brunswick
Keywords
08-09 $
Cumulative
Investigator
Chen, Robert P.-C.
IWK Health Centre
Remodelling of the intrinsic
cardiac nervous system by left to
right cardiac shunts.
Intrinsic cardiac neuron,
shunt, stent, ductus
arteriosus, congenital heart
disease.
20062009
47,000
141,000
I
Currie, R. William
Dalhousie
University
Heat shock proteins and cardiovascular protection.
Heat shock proteins, blood
vessels, inflammation, heart,
brain.
20062009
47,000
141,000
I
Lee, Timothy D.G.;
Hirsch, Gregory M.;
Ostry, Avrum J.
Dalhousie
University
Etiology of allograft vasculopathy
after cardiac transplantation: role
of pre-existing vascular disease.
Chronic rejection, allograft
vasculopathy, transplantation.
20082011
49,986
49,986
I
Legare, JeanFrancois
Dalhousie
University
Kinetics of neutrophil trafficking
in post ischemic myocardium.
Neutrophil, inflammation,
myocardial infarction, cell
adhesion, chemokines.
20062009
47,000
141,000
I
McDonald, Terence
F.
Dalhousie
University
Regulation and biophysical
properties of inwardly-rectifying
IK1 in heart cells.
Patch-clamp, cardiomyocytes, Kir (IK1) channels,
regulation, rectification.
20072010
47,000
94,000
I
O'Blenes, Stacy B.
Dalhousie
University
The importance of timing in the
repair of myocardial infarction
by transplantation of skeletal
myoblasts: defining the role
and therapeutic potential of
hepatocyte growth factor.
Cell transplantation,
heart failure, growth factor,
coronary artery disease.
20082010
50,000
50,000
I
Tabrizchi, Reza
Memorial
University of
Newfoundland
Drugs and venous system.
Mean circulatory filling
pressure, cardiac output,
regional blood flow, blood
volume, venous resistance,
blood pressure, arterial
resistance.
20072010
34,849
69,533
I
Waisman, David M.
Dalhousie
University
Defining the physiological
function of S100A10 with the
S100A10-knockout mouse.
S100A10, annexin,
fibrinolysis, plasminogen,
plasmin.
20082011
50,000
50,000
I,II
Project
Term
Theme
$ to 2009
II: Clinical
111
Nova Scotia
Project
Investigator
Blanchard, Chris
M.; Giacomantonio,
Nicholas B.;
Rhodes, Ryan E.;
Reid, Robert D.;
Spence, John C.;
McGannon, Kerry
Dalhousie
University
Why aren’t women engaging in
as much exercise during and after
cardiac rehabilitation as men? A
social ecological perspective.
Gender, social ecological
theory, exercise, cardiac
rehabilitation.
20072010
48,385
92,490
III,IV
Dupré, Denis J.
Dalhousie
University
Specificity of signaling of beta2adrenergic AT1 angiotensin homo
and heterodimeric receptor
complexes.
G protein coupled receptor,
BRET, trafficking, chaperone.
20082011
50,000
50,000
I
Gardner, Martin J.;
Horacek, B. Milan
Dalhousie
University
Electrocardiographic characteristics
of arrhythmogenic right ventricular
cardiomyopathy.
Cardiac clinical
electrophysiology,
biomedical engineering.
20062009
44,000
111,665
I,II
Howlett, Susan E.
Dalhousie
University
Ischemic preconditioning in
ventricular myocytes from young
adult and aged animals.
Aging, ischemia and
reperfusion, ischemic
preconditioning,
arrhythmias, ventricular
myocyte.
20062009
47,000
141,000
I
McLeod, Roger S.
Dalhousie
University
Assembly and function of
adiponectin oligomers.
Adiponectin, liver, assembly,
adipocyte, metabolism.
20072010
47,000
94,000
I
McMaster,
Christopher R.
Dalhousie
University
Inherited infantile x-linked
cardiomyopathies: understanding
the molecular function of tafazzin.
Phospholipid, cardiolipin,
metabolism, mitochondria,
heart disease.
20082011
50,000
50,000
I
Parkash, Ratika;
Sapp, John L.;
Basta, Magdy N.;
Gardner, Martin J.;
Tang, Anthony S.L.;
Wells, George A.
Dalhousie
University
Abnormalities in rhythm in
the cardiac resynchronization/
defibrillation in advanced heart
failure trial.
Heart failure, implantable
defibrillator, cardiac
resynchronization,
ventricular arrhythmias,
sudden death.
20062009
50,000
150,000
I,II,III,IV
Pasumarthi, Kishore
Babu S.
Dalhousie
University
Characterization of proteins
regulating cardiomyocyte cell cycle.
Cardiomyocyte cell cycle,
myocardial repair, gene
transfer, ER stress, proteinprotein interactions.
20072010
44,000
88,000
I
Term
Cumulative
Theme
$ to 2009
112
Keywords
08-09 $
Investigator
Pilote, Louise;
Karp, Igor;
Bacon, Simon L;
Chalifour, Lorraine
E.; Cox, Jafna L.;
Dasgupta, Kaberi;
Daskalopoulou,
Styliani-Stella;
Eisenberg, Mark
J.; Engert , James
C.; Ghali, William
A.; Hamet, Pavel;
Humphries, Karin
H.; Khan, Nadia
A.; Lavoie, Kim L.;
Norris, Colleen
M.; Rabi, Doreen
M.; Stark, Ken D.;
Tagalakis, Vicky;
Tremblay, André;
Tu, Jack V.
McGill University
Project
Keywords
Term
08-09 $
Cumulative
Theme
$ to 2009
syndrome.
20082011
47,000
47,000
II,III,IV
Putnam, Robert
Dalhousie
Wayne; Burge,
University
Frederick I.; Lawson,
Beverley J.; Sketris,
Ingrid S.; Veugelers,
Paul J.; Natarajan,
Nandini; Mann,
Elizabeth O.;
Godwin, Marshall S.
Hypertension in type 2 diabetes in
primary care: how much do drugs
matter in reaching target blood
pressure?
Hypertension, type 2
diabetes, cardiovascular
risk, primary care,
pharmacological therapy.
20072009
22,090
46,865
II,III
Robertson, George
S.
Enhancement of cognitive
function after ischemic brain
injury: assessment of the role of
erythropoietin.
Erythropoietins, spatial
memory, stroke, functional
recovery.
20082011
50,000
50,000
I,II
Keywords
Term
Dalhousie
University
Investigator
Morshead, Cindi M.; University of
Corbett, Dale R.;
Toronto
Shoichet, Molly S.
Project
08-09 $
Cumulative $
Theme
to 2009
The development of drug and cell
delivery systems for use in stem cell
based therapies to treat stroke.
II: Clinical
Drug and cell delivery,
neural stem cells, transplantation, endogenous
stimulation, rehabilitation.
20082011
40,000
40,000
I
113
APPENDIX
D
RESEARCH CHAIRS, PROFESSORSHIPS, AND INVESTIGATORSHIPS
Photo: Dr. Philip Teal (University of British Columbia) holds the Sauder Family / Heart and Stroke Foundation of British Columbia & Yukon Professorship in
Clinical Stroke Research.
Research Chairs, Professorships, and Investigatorships
Research Chairs
Title
Type
Dr. Christopher Buller,
University of British Columbia
The Sauder Family and Heart and Stroke
Foundation of BC & Yukon Chair in Cardiology
Cardiology
Foundation
HSFBCY
173,346
Dr. Yu Tian Wang,
The Heart and Stroke Foundation of BC & Yukon
Stroke
HSFBCY
107,331
Dr. Henry Duff,
University of Calgary
Heart and Stroke Foundation of Alberta, NWT &
Nunavut Chair in Cardiovascular Research
Cardiology
HSFA
186,500
Dr. Sonia Anand,
McMaster University
Heart and Stroke Foundation of Ontario /
Michael G. DeGroote Chair in Population Health
Research
Population Health
HSFO
0*
Dr. Heather Arthur,
McMaster University
Heart and Stroke Foundation of Ontario /
Michael G. DeGroote Chair in Cardiovascular
Nursing
Cardiac Nursing
HSFO
77,722
Dr. Fred Keeley,
Hospital for Sick Children
Heart and Stroke Foundation of Ontario / Robert
M. Freedom Chair in Cardiovascular Science at
the Hospital for Sick Children
Cardiology
HSFO
90,000
Dr. Peter Liu,
University of Toronto
Heart and Stroke Foundation of Ontario Polo for
Heart Chair at the University of Toronto
Cardiology
HSFO
0*
Dr. Jeffrey Weitz,
McMaster University
Heart and Stroke Foundation of Ontario / J.
Fraser Mustard Chair in Cardiovascular Research
at McMaster University
Cardiology
HSFO
23,789
Dr. Salim Yusuf,
McMaster University
Heart and Stroke Foundation of Ontario Chair in
Cardiovascular Disease at McMaster University
Cardiology
HSFO
72,539
Dr. Kim Raine,
University of Alberta
Heart and Stroke Foundation of Canada and
CIHR Institute of Population and Public Health
Applied Public Health Chair
Obesity
HSFC
0†
Professorships
Title
Type
Dr. Philip Teal,
The Sauder Family and Heart and Stroke
Foundation of BC & Yukon Professorship in
Clinical Stroke Research
Clinical Stroke
Dr. Ken Butcher,
Nunavut Professorship in Stroke Research
Dr. Michael Hill,
Nunavut Professorship in Stroke Research
Foundation
08-09 $ Value
08-09 $ Value
HSFBCY
82,918
Stroke
HSFA
80,000
Stroke
HSFA
80,000
Investigatorships
Title
Type
Dr. Sean Dukelow,
Nunavut Investigatorship in Stroke Rehabilitation
Research‡
Stroke
Foundation
HSFA
08-09 $ Value
50,000
Typically, Research Chairs and Professorships are funded via an endowment from the provincial Foundations listed as well as endowments from other sources.
Payments from endowed fund temporarily suspended in 2008-2009.
Funding from partner organizations began in 2007-2008; Heart and Stroke Foundation funding will begin in 2009-2010.
‡
Investigatorship is contingent upon recruitment of the Stroke Chair (University of Calgary) and will end with the appointment of an incumbent to the Chair
position.
*
†
116
APPENDIX
E
PROVINCIAL PERSONNEL AWARDS
Photo: Dr. Andrew D. Krahn (University of Western Ontario) was the recipient in 2008-2009 of a Career Investigator Award from the Heart and Stroke
Foundation of Ontario for his project titled “Inherited arrhythmias: clinical and genetic assessment of primary electrical disease”.
Saskatchewan
Manitoba
Master’s Studentship Award
Award: $17,500
Sanofi Aventis / Heart and Stroke Foundation of Manitoba
Award in Cardiology
Award: $10,000
Awardee
Supervisor
Institute
Gerin, Janelle
Teare, Gary
University of Saskatchewan
Awardee
Supervisor
Institute
Longmuir, Nicole
Cayabyab, Francisco
Mousavi, Negareh
Hodge, Steven
St. Boniface General Hospital
Award: $5,000
Award: $4,500
Awardee
Supervisor
Institute
Awardee
Supervisor
Institute
Feed, Darren; Rakesh, Arora
University of Manitoba
Colborne, Emily
Neary, J. Patrick
University of Regina
Guirgis, Mina
Longmuir, Nicole
Cayabyab, Francisco
Oomah, Sacha Jassal, Davinder
Pham, Quang
Weissgerber,
Jordan
Walz, Wolfgang
Ethans, Karen; Casey, Alan;
Koropas, Randy
Red River College (RRC) Summer Studentship Award
Award: $4,000
Awardee
Supervisor
Institute
Dunn, Lori
Tappia, Pram
Red River College
Fakharuddin, Ken
Suh, Miyoung; Aliani,
Michel; Pierce, Grant
Red River College
Gerbasi, Alyssia
Czubryt, Michael
Red River College
Te, Graziella
Fernyhough, Paul
Red River College
Ontario
Distinguished Scientist Awards
Awardee
Institute
Award
Description
Term
Floras, John S.
(1)
University Health
Network
Rick Gallop Award for Research
Excellence
The five highest rated Ontario Grant-inAid recipients are eligible to compete for
a supplementary grant for an innovative,
"out-of-the-box" research project.
20082009
50,000
50,000
Floras, John S.
(2)
University Health
Network
Excellence
20082009
50,000
50,000
Schlichter,
Lyanne C.
University Health
Network
Excellence
20082009
50,000
50,000
118
08-09 $
Total $*
Awardee
Institute
Award
Description
Term
Weitz, Jeffrey I.
McMaster University
Excellence
20082009
50,000
50,000
Parker, John D.
University of Toronto Sifton Distinguished Scientist
Award
Supplementary funding for five years for
the highest rated Career Investigator at
the University of Toronto.
20082012
10,000
40,000
Spencer,
Frederick A.
McMaster University
Fortino's Distinguished Scientist Supplementary funding for five years for
Award
the highest rated Career Investigator at
McMaster University.
20072012
10,000
50,000
Bolz, SteffenSebastian
University of Toronto Maureen Andrew New
Investigator Award
20082009
10,000
10,000
Supplementary funding for one year for
the highest rated Ontario-based New
Investigator.
08-09 $
Total $*
Career Investigator Awards
Awardee
Institute
Project
Alter, David A.
St. Michael's Hospital
Cardiovascular treatment & outcomes disparities among
high-risk populations.
20062011
87,950
439,750
Austin, Peter C. Sunnybrook Health Sciences
Centre
Statistical methods for cardiovascular research.
20082013
87,950
439,750
Austin, Richard
C.
McMaster University
Role of endoplasmic reticulum stress in atherothrombotic
disease.
20062011
87,950
439,750
Backx, Peter H.
Mechanisms of heart disease.
20042009
87,950
439,750
Beanlands,
Rob S.B.
University of Ottawa Heart Institute
Metabolism, energetics and neurohormonal signaling and
their response to therapy in dysfunctional myocardium.
20082013
87,950
439,750
Bendeck,
Michelle P.
Smooth muscle cell interactions with the extracellular matrix
in atherosclerosis.
20042009
87,950
439,750
Chan, Anthony
K.C.
McMaster University
Study of the pathogenesis and treatment of pediatric disease
related to the hemostatic system.
20052010
87,950
439,750
Chidiac, Peter
University of Western Ontario
Impact of RGS proteins on cardiovascular function.
20082013
87,950
439,750
Crowther, Mark
A.
McMaster University
Optimizing anticoagulant therapy.
20042009
87,950
439,750
Cybulsky,
Myron I.
University Health Network
Initiation of atherosclerosis: mechanisms and cell biology.
20072012
87,950
439,750
Drangova,
Maria
Robarts Research Institute
Cardiac imaging for therapy guidance and pre-clinical
research studies.
20072012
87,950
439,750
Feng,
Qingping
Mechanisms of heart failure.
20052010
87,950
439,750
Ferguson,
Stephen G.
Molecular regulation of G protein-coupled receptor signal
transduction, desensitization and resensitization.
20082013
87,950
439,750
Floras, John S.
Cardiovascular regulation in men and women with heart
failure and hypertension.
20062009
43,975
219,875
II: Clinical
Term
08-09 $
Total $*
119
Awardee
Institute
Project
Funk, Colin D.
Queen's University
Lipoxygenase and cyclooxygenase pathways in
20062011
87,950
439,750
Ginsberg,
Jeffrey S.
McMaster University
Diagnosis and management of thromboembolic disorders in
multiple patient populations.
20072010
87,950
219,875
Hayward,
Catherine P.
McMaster University
Studies of novel platelet and vascular secretory proteins.
20052010
87,950
439,750
Husain,
Mansoor
Molecular regulation of vascular smooth muscle cell
proliferation and contractility.
20042009
87,950
439,750
Kearon, Clive
McMaster University
Optimizing treatment and diagnosis of venous
thromboembolism.
20082013
87,950
439,750
Koschinsky,
Marlys L.
Queen's University
Mechanisms of atherothrombosis: analysis of lipoprotein and
fibrinolytic risk factors.
20062011
87,950
439,750
Krahn, Andrew
D.
Inherited arrhythmias: clinical and genetic assessment of
primary electrical disease.
20082013
87,950
439,750
Lewis, Gary F.
Determining the mechanisms of the dyslipidemia of insulin
resistant states and Type 2 diabetes.
20082011
87,950
219,875
Li, Ren-Ke
Restoration of cardiac function: cellular regeneration and
matrix reconstruction.
20062011
87,950
439,750
Liu, Fang
Addiction and Mental Health
The role of protein-protein interaction in neurological/
neurophsyciatric diseases.
20082013
87,950
439,750
Marsden, Philip University of Toronto
A.
The human nitric oxide synthase genes: relevance to disease.
20082011
87,950
219,875
Maurice,
Donald H.
Queen's University
PDEs in blood vessels.
20062011
87,950
439,750
Park, David S.
Ottawa Health Research Institute
Pathways which regulate neuronal death.
20062011
87,950
439,750
Parker, John D.
Clinical studies concerning nitrate pharmacology and
autonomic physiology in congestive heart failure.
20072012
87,950
439,750
Pickering, J.
Geoffrey
Role of smooth muscle cells in vascular disease.
20082011
87,950
219,875
Rodger, Marc
A.
Thrombophilia and placenta mediated pregnancy
complications.
20072012
87,950
439,750
Spencer,
Frederick A.
McMaster University
Clinical epidemiology and management of cardiovascular
and venous thromboembolic disease.
20072012
87,950
439,750
Steinman,
David A.
Image-based modelling of hemodynamics and
cerebrovascular disease.
20042009
87,950
439,750
Tu, Jack V.
Sunnybrook Health Sciences
Centre
Improving the quality of heart and stroke care in Canada.
20052010
87,950
439,750
Roles of versican in mediating leukocyte and endothelial cell
activites.
20062011
87,950
439,750
Yang, Burton B. Sunnybrook Health Sciences
Centre
120
Term
08-09 $
Total $*
Clinician Scientist Awards
Awardee
Institute
Project
Term
08-09 $
Total $*
Al-Hesayen,
Abdul O.
Exploring the role of cGMP in human heart failure.
20072010
64,000.00
192,000.00
Askalan, Rand
Neuroprotection by inhibitors of apoptosis proteins
following neonatal stroke.
20072010
64,000.00
192,000.00
Atzema, Clare
Centre
Emergency department triage and time to ECG: the effect
on reperfusion delays for AMI patients.
20072010
64,000.00
192,000.00
Billia, Filio
Regulation of cardiac muscle growth and proliferation by
cytoplasmic p27K1P1.
20072010
64,000.00
192,000.00
Birnie, David H. University of Ottawa Heart Institute
Importance of mechanical dyssynchrony and
resynchronization therapy in heart failure patients.
20062009
70,250.00
210,750.00
Chauhan, Vijay
S.
Characterizing ventricular repolarization alternans in human
cardiomyopathy.
20072010
70,250.00
210,750.00
Dick,
Endothelial progenitor cell modification to improve left
2008-
70,250.00
210,750.00
Alexander J.
Centre
ventricular function post myocardial infarction.
2011
Gladstone,
David J.
Centre
Stroke prevention for high-risk patients: Identifying barriers
and creating solutions.
20062009
64,000.00
192,000.00
Gollob,
Michael H.
Genetic determination of atrial fibrillation.
20062009
64,000.00
192,000.00
Kahr, Walter
H.A.
The role of VPS33B in platelet alpha granule formation.
20062009
70,250.00
210,750.00
Ko, Dennis T.
Centre
Appropriateness and necessity of coronary angiogram.
20062009
64,000.00
192,000.00
Kutryk, Michael
J.B.
Novel application of progenitor endothelial cells.
20062009
70,250.00
210,750.00
Leong-Poi,
Howard M.
Ultrasound-targeted gene and cell-based strategies for
therapeutic angiogenesis.
20082011
70,250.00
210,750.00
Opavsky, Mary
Anne
The coxsackie-adenovirus receptor in heart infection and
heart failure.
20072010
70,250.00
210,750.00
Rocca, Antonio
Mediation of flow-induced arterial remodelling.
20082011
64,000.00
192,000.00
Salbach, Nancy University of Toronto
M.
Building physiotherapists' capacity to implement evidencebased stroke rehabilitation.
20082011
64,000.00
192,000.00
Saposnik,
Gustavo
Premature Stroke Associated with Recency of Immigration
to Ontario (PRESARIO).
20082011
64,000.00
192,000.00
Spears, Julian
International, prospective, multi-center study of
radiographic and clinical events in the management of
cerebral aneurysms ≥ 1cm.
20062009
64,000.00
192,000.00
Nursing Post-Doctoral Research Fellowship Awards
Awardee
Supervisor
Institute
Project
Term
Sherifali, Diana
T.
Gerstein, Hertzel
C.
McMaster University
Appraisal of a community approach to
facilitated self-management of diabetes
mellitus.
20072010
II: Clinical
08-09 $
59,000
Total $*
177,000
121
Research Fellowship Awards
Awardee
Supervisor
Institute
Project
Term
08-09 $
Total $*
Bose, Arpita
Buchanan, Lori
University of Windsor
Recovery in post-stroke aphasia:
psycholinguistics and psychosocial perspective.
20062009
47,500
142,500
Sun, Jiangfeng
O’Brien, Edward
University of Ottawa
Heart Institute
Role of estrogen receptor beta in endothelial
progenitor cell-mediated vascualr repair.
20072009
47,500
95,000
Master’s Studentship Awards
Awardee
Supervisor
Institute
Project
Term
08-09 $
Total $*
Abdirahman, Ifrah
H.
Wang, Lisheng
Role of integrin linked kinase in the
development of earliest endothelial ancestors.
20082009
18,000
18,000
Armstrong, David
W.J.
Pang, Stephen C.
Queen's University
Interaction between the natriuretic peptide
system and heme oxgyenase in experimental
myocardial infaraction.
20082009
18,000
18,000
Bryan, Sean A.
Wang, Rui
Lakehead University
The role of hydrogen sulfide in cardiac redox
regulation and inflammation.
20082009
18,000
18,000
Chang, Ying-Ju R.
Jiang, Shucui
McMaster University
Neuroprotective properties of guanosine in
experimental stroke.
20082009
18,000
18,000
Chiswell, Kathryn
G.
Bakovic, Marica
University of Guelph
Regulation of energy expenditure and
muscule diacyglycerol metabolism in PCYT2
knock-out mice.
20082010
18,000
18,000
Chu, Zane E.
Radisic, Milica
Characterization and proliferation of islet-1
cardiac progenitor cells.
20082010
18,000
36,000
Esseltine, Jessica L. Ferguson, Stephen
University of Western
Ontario
Rab GTPase regulation of angiotensin
receptor trafficking and signaling.
20072009
18,000
36,000
Flanengo, Maria F.
Shoemaker, Kevin
Ontario
Associating baseline levels of medial
prefrontal cortex activity with autonomic
cardiovascular control.
20072009
18,000
36,000
Fuller, Mark T.
McMaster University
Investigation of the role of the HDL receptor,
SR-BI in endothelial cells on atherosclerosis.
20082010
18,000
36,000
Haley, Jason P.
Boughner, Derek R.
Ontario
Bioactive scaffolds for heart valve tissue
engineering.
20082009
18,000
36,000
Han, Kristina
Koschinsky, Marlys L.
Queen's University
The cellular biochemistry of apolipoprotein(a)
secretion: relationship between Apo(a) size
and secretion efficiency.
20072009
18,000
36,000
Ingves, Matthew V.
Ferguson, Alastair V.
Queen's University
Area postrema neuronal by prokineticin 2.
20082009
18,000
18,000
Kirk, Megan E.
Tranmer, Joan E.
Queen's University
The influence of age on the relationship
between work and home demands and
cardiovascular risk in female healthcare
workers.
20082009
18,000
18,000
Kuraitis, Drew B
Suuronen, Erik J.
SDF-1 microspheres and collagen matrix
for recruitment of endogenous circulating
progenitor cells.
20082009
18,000
18,000
Lang, Sean TJ.
Ni, Heyu
Role of B3 integrin in angiogenesis and
differentiation of endothelial progenitor cells.
20082010
18,000
36,000
122
Awardee
Supervisor
Institute
Project
Term
08-09 $
Total $*
Majeed, Habeeb
Wells, Phillip S.
Low dose vitamin K to stabilize patient INRs
on warfarin anticoagulation: towards clinical
implementation.
20082009
18,000
18,000
McNicholl, Eric T.
Melacini, Giuseppe
McMaster University
Structural basis for the cAMP signal translation
in PKA by NMR.
20072009
18,000
36,000
Mitchell, Andrea J.
Prato, Frank S.
Ontario
Myocardial cell therapy: optimizing injection
strategy to maximize transplant cell survival.
20082009
18,000
18,000
Molgat, Andre S.D.
Sorisky, Alexander
Macrophage secreted factors and adipose cell
survival.
20082009
18,000
18,000
Nowacki, Nathaniel Dr. John McDermott
B. Nowacki
York University
Regulation of MEF2 activity in cardiac
myocytes.
20072009
18,000
18,000
Pak, Melissa
Tschalovsky, Michael
E.
Queen's University
Dysfunctional muscle blood flow regulation
during exercise in type II diabetes.
20072009
18,000
36,000
Pitzul, Kristen B.
Cregan, Sean
Ontario
Role of AKT, JNK and GSK3 signaling on
puma induction model, apoptosis, stroke,
PUMA.
20082009
18,000
18,000
Rabin, Jennifer S.
Rosenbaum, R.
Shayna
York University
An fMRI investigation of mental state
attributions in stroke patients.
20082009
18,000
18,000
Rousseaux,
Maxime W.C.
Park, David S.
Mrf2 is a downstream target of DJ-1 in an
ischemic stroke model.
20082009
18,000
18,000
Seibert, Tara A.
O'Brien, Edward
Understanding the vascular protective
mechanisms of an estrogen- inducible protein
using gene expression profiling.
20072009
18,000
36,000
Shikatani, Eric A.
Haas, Tara
York University
Cellular mechanisms underlying
corticosterone-dependent inhibition of
angiogenesis.
20072009
18,000
36,000
Szabo, Lian I.
Ward, Christopher A. Queen's University
The compartmentation of cyclic nucleotides in
ventricular cardic myocytes.
20082009
18,000
18,000
Tishinsky, Justine
M.
Robinson, Lindsay E.
Fatty acids and regulation of adiponectin in
human adipocytes.
20082009
18,000
18,000
Uguccioni, Giulia
Hood, David A.
York University
The importance of PGC-1a in cardiac muscle.
20082009
18,000
18,000
Vu, Trang T.
Weitz, Jeffrey I.
McMaster University
Impact of gamma fibrinogen on clot formation
and clot lysis at sites of plaque rupture.
20082010
18,000
36,000
Yarmo, Michelle
Sorisky, Alexander
Macrophage-adipose cell interactions in
obesity and cardiovascular disease.
20072009
18,000
36,000
II: Clinical
123
Medical Student Awards
Award: $4,000 or $6,000
John D. Schultz Science Student Scholarships
Award: $4,000
Awardee
Supervisor
Institute
Awardee
Supervisor
Institute
Ahmed, Kashif
Maar, Marion
Laurentian University
Ahmed, Mavra
Mak, Susanna
Mount Sinai Hospital
Appleton, Andrew
Rogers, Kem
Ontario
Babona-Pilipos,
Robart
Morshead, Cindi
Ayeni, Olubukunola
MacLean, David
Pang, Stephen
Queen's University
Charbonneau, Valerie
Stiell, Ian
Brander, Emily
P.A.
Cooper, Elizabeth
Chaudhuri, Bob
Lakehead University
Ciriello, John
Creider, Julia
Hegele, Robert
Ontario
Bruckschwaiger,
Emily B.
Ontario
Chan, Anthony K.C.
McMaster University
Davis, Mark
Backx, Peter
Chan, Veronica
H.T.
Cho, Eunae
Fehlings, Michael G.
Dewhirst, Sebastian
Ruddy, T.
University Health
Network
Digby, Genevieve
Parker, Chris
Queen's University
Hegele, Robert A.
Donlan, Janice
Athale, Uma
McMaster University
Danielson, Rachel
R.
Robarts Research
Institute
Forth, Penny
Ross, Greg
Dewan, Ambuj Y.
Wells, R. Glenn
Garnett, Meghan
Grise, Mary
Heart Institute
Khaper, Neelam
Lakehead University
DiMattia,
Alessandra S.
Huff, Murray W.
Hagerty, Marlon
Ontario
Harris, David
Chaudhuri, Bob
Lakehead University
Backx, Peter H.
Madani, MohammadAmin
Spence, David
Ontario
Djazayeri,
Shabdis
University Health
Network
Egier, David
Igdoura, Suleiman A.
McMaster University
Mansour, Marlene
Sharma, Michael
Jones, Nina
Soor, Gursharan
Butany, Jagdish
Fortino, Megan
A.
Twiddy, Matthew R.
Adams, Michael A. Queen's University
Fuller, Mark T.
McMaster University
Gao, Jennifer L.
Stewart, Alexandre
F.R.
Heart Institute
Haque, Nihal
Weitz, Jeffery I.
McMaster University
Hesketh, Caitlin
C.
Ferguson, Alastair V.
Queen's University
Jiang, Nan N.
Li, Ren-Ke
University Health
Network
Jin, Chunzi Jenny
Ng, Dominic
Kawaguchi, Sarah
Husain, Mansoor
University Health
Network
Lai, Carolyn
Opavsky, Anne
Hospital for Sick
Children
Vecchiarelli, Jonathan
Kutryk, Michael
Queen's University
Yan, Hanmu
Karkouti, Keyvan
Martin L. Wills High School Scholarships
Award: $2,250
Awardee
Supervisor
Institute
Caragianis,
Anthony N.M
Leenen, Frans
University of Ottawa Heart
Institute
Husain, Nasir W.
Letarte, Michelle
Igdoura, Fatima
Trigatti, Bernardo
McMaster University
Leung, Alexander
Robinson, Lisa
Li, Mingxi
Liu, Peter
Lao, Franchelle
Robinson, Lindsay
Nurmohamed,
Sabrina
Cybulsky, Myron I.
Leung, William
P.H.
Drysdale, Thomas A.
Ontario
Romanowski,
Adam
Hegele, Robert
Robarts Research Institute
Lewandowski,
Adam
Chen, Hsiao-Huei
Ottawa Health Research
Institute
Sadi,
Geentanjalee
Husain, Mansoor
Li, Meredith
Liu, Peter
University Health
Network
Wang, David D.
Bendeck, Michelle
P.
Makdessi,
Anthony H.
McKelvie, Robert S.
McMaster University
124
Awardee
Supervisor
Institute
Mazzetti, Adam
Austin, Richard
McMaster University
McLeod,
Jonathan K.
Peters, Terence M.
Robarts Research
Institute
No, Eun Kyung
Sweeney, Gary
York University
Nurmohamed,
Aliya
Heximer, Scott P.
Osman, Aweis
Park, David S.
Institute
Poku, Kwaku
Nanhakumar,
Kumaraswamy
University Health
Network
Qayyum, Fareeha
A.
Grover, Ashok K.
McMaster University
Roufaiel, Mark
Marsden, Philip A.
Setterfield,
Jeremy G.
Morris, Catherine E.
Heart Institute
Sikkema, Sarah R.
Pickering, J. Geoffrey
Robarts Research
Institute
Sniuolis, Paul R.
Werstuck, Geoffrey H. McMaster University
Srigunapalan,
Suthan
Simmons, Craig A.
Suen, Colin M.
Gramolini, Anthony
O.
Syrett, Andrew J.
Bennett, Steffany A.L.
Wong, Eric H.
Bendeck, Michelle P.
Wu, Jane Z.Z.
So, Derek Y.F.
Heart Institute
Xue, Rui
Wen, Xiao-Yan
Yan, Ran
Redington, Andrew
N.
Hospital for Sick
Children
Ying, James X.
Gollob, Michael H.
Heart Institute
II: Clinical
125
126
APPENDIX
F
OTHER PROVINCIAL INITIATIVES
Photo: Dr. Sonia Anand (McMaster University) was the recipient in 2008-2009 of a Pilot Project Grant from the Heart and Stroke Foundation of Ontario for
her project titled “Understanding the contextual factors influencing health behaviours in an Aboriginal community”.
British Columbia / Yukon
Special Initiative: CardioSHARE - Cardiovascular Semantic Health and Research Environment
Principal Investigators: Dr. Bruce McManus and Dr. Mark Wilkinson, Providence Heart + Lung Institute
$360,000 over 2 years (March 1, 2007 to Feb. 28, 2009) to develop a data search, classification, and management system for ischemic
heart disease.
Alberta / Northwest Territories / Nunavut
Awardee
Institute
Project
Term
08-09 $
Total $*
Hemmings, Denise G.
Regulation of vascular responses by sphingosine 1-phosphate in pregnancy.
20082009
3,000
3,000
Saskatchewan
Biomedical Imaging and Therapy (BMIT) Beamline at the Canadian Light Source HSFS annual commitment is $100,000 for five years from 2005 to 2009.
Ontario
Program Grants
Principal
Investigator
Institute
Project
Austin,
Richard C.
McMaster University
Beanlands,
Rob S.B.
Term
08-09 $
Total $*
Identification and characterization Janssen, Luke J.; Nurse, Colin A.; Trigatti,
of novel and therapeutic strategies Bernardo L.; Gross, Peter L.; Igdoura,
that decrease atherothrombotic
Suleiman A.
disease.
20082013
250,000
1,250,000
Heart Institute
Elucidation of metabolic and cellular function alterations in dysfunctional myocardium and their
response to therapy.
de Kemp, Robert A.; Ruel, Marc Andre;
DaSilva, Jean N.; Harper, Mary-Ellen;
Gollob, Michael H.; Suuronen, Erik J.
20072012
249,828
1,249,517
Gotlieb,
Avrum I.
University Health
Network
Cell biology of atherosclerosis.
Bendeck, Michelle P.; Courtman, David
W.; Cybulsky, Myron I.; Husain, Mansoor;
Marsden, Philip A.; Stewart, Duncan J.;
Strauss, Bradley H.; Ward, Michael E.;
Heximer, Scott P.
20052010
250,000
1,249,915
Huff, Murray
W.
Robarts Research
Institute
Cellular programs and responses
in atherosclerosis.
Ferguson, Stephen G.; Hegele, Robert A.;
Pickering, J. Geoffrey
20062011
250,000
1,250,000
Wells, Philip
S.
Ottawa Health
Research Institute
Thrombophilia: from bench to
bedside to health economics and
policy.
Rodger, Marc A.; Walker, Mark; Gagnon,
France
20042009
250,000
1,250,000
128
Co-Investigator(s)
Principal
Investigator
Institute
Project
Co-Investigator(s)
Term
08-09 $
Total $*
Brooks, Dina
University of
Toronto
Cardic rehabilitation after stroke.
Black, Sandra E.; McIlroy, William E.;
Sahlas, Demetrios James; Oh, Paul;
Bayley, Mark T.; Richardson, Denyse
L.
20062009
68,479
208,276
Brouwer,
Brenda
Queen's University
Client-centred 'tune-ups': do they
enhance physical capacity, mobility
function and community reintegration in
stroke survivors?
Garland, S. Jayne; Bryant, Dianne M.;
Connelly, Denise M.; Maly, Monica
R.; Minnes, Patricia M.; MacIntyre,
Norma J.; Pelland, Lucie C.
20062009
204,206
680,736
Popovic, Milos
R.
Toronto
Rehabilitation
Institute
Functional electrical stimulation-assisted
walking: enhancement of voluntary
walking function among persons with
severe hemiplegia post stroke.
Salbach, Nancy M.; Thabane, Lehana;
Verrier, Mary C.; Richardson, Denyse
L.; Giangregorio, Lora M.
20062009
32,265
209,946
Principal
Investigator
Institute
Project
Co-Investigator(s)
Term
08-09 $
Total $*
Logan,
Alexander G.
Mount Sinai
Hospital
Self-monitoring of blood pressure in
primary care in older (45+ years) diabetic
patients with uncontrolled systolic hypertension.
Irvine, Jane M.; McIsaac, Warren
J.; Feig, Denice; Easty, Anthony C.;
Cafazzo, Joseph A.; Rossos, Peter G.;
Davis-Halifax, Nancy; Kelly, Catherine
M.; Parkes, Robert K.
20062009
204,003
629,619
Myers, Martin
G.
Sunnybrook Health Automated office blood pressure meaSciences Centre
surement.
Tobe, Sheldon W.; Kaczorowski,
Janusz; Godwin, Marshall S.; Kiss,
Alexander J.; Dawes, Martin
20052009
358,043
1,507,534
Project
Co-Investigator(s)
Term
08-09 $
Total $*
Social determinants of child hypertension.
Shoemaker, J. Kevin; O'Leary,
Deborah D.; Klentrou, Panagiota;
LeBlanc, Paul J.; Hay, John A.; Cairney,
John; Liu, Jian; Roy, Brian D.; Hood,
Colleen; Zinga, Dawn M.
20072012
100,085
Principal
Investigator
Institute
Wade, Terrance Brock University
J.
II: Clinical
500,357
129
Pilot Project Grants Principal
Investigator
Institute
Project
Anand, Sonia
McMaster University
Understanding the contextual factors
influencing health behaviours in an
Aboriginal community.
Grimshaw,
Jeremy M.
Institute
Gupta, Milan
Term
08-09 $
Contextual environment,
obesity, health behaviour,
Aboriginal.
20082009
49,657
I,II,IV
Implementation research in smoking
cessation treatment practice: applying
psychological theories to understand
family physician's intention to integrate
the recent progress in tobacco
dependence treatment into their
practice.
Implementation research,
smoking cessation,
psychological theories, family
physicians, behavioural
intention.
20082009
47,721
III,IV
A pilot study of language and ethnic
specific cardiovascular risk counselling
versus usual care in South Asians with
Ethnicity, compliance,
counselling, prevention,
20082009
50,000
II,IV
GwadryLondon Health Sciences
Sridhar, Femida Centre
Internet-based tool to enhance
compliance in heart failure patients
(I-TEACH).
Patient self-management,
congestive heart failure,
patient education, web-based
tools, medication compliance.
20082009
50,000
II,III,IV
Mbikay,
Majambu
Institute
PCSK9 genetic variants, hypocholesterolemia and diabetes in AfricanCanadians.
Diabetes, dyslipidemia,
proprotein convertase, genetic
polymorphisms, AfricanCanadians.
20082009
50,000
Morrison,
Katherine M.
McMaster University
PURE (Prospective Urban Rural
Epidemiology) CHILD - Societal and
biological determinants of obesity in
the offspring of adults enrolled in the
PURE Study - A pilot.
CV health, family, children,
obesity, determinants.
20082009
49,985
IV
Prasad,
Ramesh
Traditional and novel cardiovascular
risk factors in South Asian kidney
transplant recipients living in Ontario.
Cardiovascular risk,
adiponectin, biomarkers,
South Asians, kidney
transplantation.
20082009
50,000
II
Reid, Robert D. University of Ottawa Heart
Institute
Varenicline versus transdermal nicotine
patch for smoking cessation in patients
with coronary heart disease: a pilot
randomized trial.
Coronary heart disease,
smoking cessation, varenicline,
nicotine replacement therapy,
prevention.
20082009
48,882
II,III,IV
Richmond,
Chantelle
Ontario
The SOAHAC food choice study.
Aboriginal health, dietary
patterns, food choice,
environmental and social
determinants, acculturation.
20082009
49,850
III,IV
Saposnik,
Gustavo
Indicators of quality of stroke care
associated with clinical outcomes.
Stroke, quality of care,
mortality, hospital
re-admission, health services
research, health policy.
20082009
49,860
II,III
130
Keywords
Theme
Principal
Investigator
Institute
Project
Keywords
Term
08-09 $
Theme
Simpson,
Christopher
Queen's University
Drivers with implantable cardioverter
defibrillators (ICDs) in Ontario:
Database linkage feasibility - A pilot
project.
Medical fitness to drive,
legislation, motor vehicle
accidents, reporting, public
safety.
20082009
49,476
II,III,IV
Slovinec
D'Angelo,
Monika
University of Ottawa Heart
Institute
Effectiveness of individualized
motivational support on adherence to
regular exercise in cardiac rehabilitation outpatients.
Cardiac rehabilitation, exercise
adherence, motivational
support.
20082009
48,219
II,III
Vaillancourt,
Christian
Institute
A survey of factors associated with
the successful recognition of agonal
breathing and cardiac arrest by 9-1-1
call takers.
Agonal breathing, cardiac
arrest, 9-1-1 call taker, theory
of planned behaviour, survey.
20082009
49,000
II,III
Verma, Subodh St. Michael's Hospital
A prospective study to compare the
functionality of HDL cholesterol to
limit endothelial dysfunction in South
Asians vs. Caucasian patients with
atherosclerosis.
South Asian ethnicity, HDL
cholesterol, endothelial
function, atherosclerosis,
oxidized LDL.
20082009
50,000
I,II
Wong, Natalie
Improving teaching of basic life
support: a randomized pilot study
of real-time feedback in CPR
performance.
Cardiac arrest, simulation, BLS
training, CPR, defibrillator.
20082009
50,000
I,II,III
Yang, Homer
Institute
Perioperative ischemia reduction study
(PROSE).
Postoperative myocardial
ischemia, postoperative ST
changes, postoperative holter
monitoring, postoperative
cardiac complications, noncardiac.
20082009
49,994
I,II,III,IV
Yusuf, Salim
McMaster University
Development of a community-profiling
instrument to measure the social and
environmental determinants of cardiovascular risk factors and disease.
Social determinants,
environment, community,
cardiovascular risk factors.
20082009
49,937
II,III,IV
Operating Grant
Principal
Investigator
Institute
Project
Co-Investigator(s)
Term
08-09 $
Tu, Jack
University of
Toronto
A pilot program of research on ethnic
differences in cardiovascular disease in
Ontario.
Shah, Baiju; Chiu, Maria
20082010
75,000
II: Clinical
Total $*
150,000
131
Heart and Stroke Foundation Centre for Stroke Recovery
Co-directors/Co-directeurs :
Dr. Antoine M. Hakim,
Dr. Sandra Black,
Sunnybrook Health Science Centre
Dr. Don Stuss,
Baycrest Centre for Geriatric Care
HSFO contribution - $5,458,000
Reflects a previously committed annual contribution, plus a fundraising campaign generated 2008-2009 contribution of $4,809,000.
Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research
Centre d’excellence en recherche cardiovasculaire Heart and Stroke/Richard Lewar
Director: Dr. Mansoor Husain,
HSFO overall contribution - $6 million
Reflects a previously committed annual 2008-2009 contribution.
Webinar
Health Services and Population Health Grants: Tips for Successful Applications
$24,000
Québec
Heart and Stroke Foundation of Québec Awards for Excellence in Research
Awards for excellence highlighting the outstanding contribution of researchers.
These awards enhanced the grants allocated to these researchers in 2008-2009:
The 4th International Conference on Preventive Cardiology Award
Dr. Eric Larose (Institut de cardiologie de Québec et Hôpital Laval) $20,000
The Desjardins Financial Security Award
Dr. Louise Pilote (McGill University Health Center and McGill University) $10,000
The John J. Day Award
Dr. Terence Hebert (McGill University) $10,000
The Jonathan-Ballon Award
Dr. Jacques Huot (Hôtel-Dieu de Québec) $10,000
The Pfizer Canada Award
Dr. Jonny St-Amand (Centre hospitalier de l’Université Laval) $10,000
132
The RBC Royal Bank Award
Dr. Mindy F. Levin (McGill University) $10,000
The Sanofi-Aventis / Bristol-Myers Squibb Canada Award
Dr. Jiangping Wu (CHUM-Hôpital Notre-Dame) $10,000
The Buckingham Lions Club Award in memory of Robert Champagne
Dr. Ariane Marelli (CUSM-Royal Victoria Hospital) $10,000
The Alfred B. Grossman Award of the EJLB Foundation
Dr. Yves Joanette (Institut universitaire de gériatrie de Montréal) $5,000
The Birks Family Foundation Award
Dr. Darren E. Richard (L’Hôtel-Dieu de Québec) $5,000
The Gladis Axler Award
Dr. Jacques Genest (CUSM-Royal Victoria Hospital) $5,000
The Marc Bourgie Foundation Award
Mrs. Cindy Charbonneau (CHUM Hôpital Notre-Dame) $5,000
Training bursaries for PhD students in Cardiovascular and Stroke Research
Partnership between the Fonds de la recherche en santé du Québec (FRSQ), the Réseau en santé cardiovasculaire (RSCV) and the Heart
and Stroke Foundation of Québec (HSFQ).
The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from the Heart and Stroke
Foundation of Québec (HSFQ).
In 2008-2009, 3 bursaries were given:
Cindy Charbonneau (Dr. Sophie Lerouge, CHUM – Hôpital Notre-Dame) $6,666.68
2nd year
Piotr Banski (Dr. Ursula Stochaj, McGill University) $6,666.66
1st year
Sean Wiltshiere (Dr. Silvia Vidal, McGill University) $6,666.66
1st year
II: Clinical
133
New Brunswick
Research Grant
Principal
Investigator
Institute
Project
Blanchard,
Chris M.
Dalhousie University
Understanding exercise behaviour from a
social ecological perspective during and
after cardiac rehabilitation.
Co-Investigator(s)
Term
08-09 $
Cumulative
Cyr, C.; Stevenson,
R.
20072010
47,000
$ to 2009
91,844
Nova Scotia
Prestigious Awards
Awardee
Institute
Award
Description
Term
08-09 $
Total $*
McMaster,
Christopher R.
Dalhousie
University
Dr. Gregory Ferrier
Award
An award for excellence in research given to the highest rated
HSFNS Grant-in-Aid recipient in honour of Dr. Gregory Ferrier.
20082009
5,000
5,000
134
APPENDIX
G
RESEARCH COMMITTEE MEMBERS
Photo: Dr. Marilyn MacKay-Lyons (Dalhousie University) was the 2008-2009 Chair of the Heart and Stroke Foundation of Nova Scotia Scientific Advisory
Committee.
2008-2009 Research Policy and
Planning Advisory Committee
2008-2009 Scientific Review
Committee Executive
Robert Côté, MD, Chair
Montréal General Hospital
Balwant Tuana, PhD, Chair
Todd Anderson, MD, Vice Chair
Foothills Hospital
Linda Waverley, PhD, Vice Chair
Robert Brooks
Chair, Heart and Stroke Foundation of Canada Board of Directors
Ex-Officio
Sally Brown
CEO, Heart and Stroke Foundation of Canada
Ex-Officio
Marla Gold
McGill University
Ron McManus
Laurie Morrison, MD
Sunnybrook & Women’s Health Sciences Centre
Ed Pryzdial, PhD
Clinical cardiovascular and cerebrovascular research: mechanistic
studies and clinical trials / health services research (A)
Gary Newton, MD, Chair
Mount Sinai Hospital
Mark Crowther, MD, Deputy Chair
McMaster University
Clinical cardiovascular and cerebrovascular research: mechanistic
studies and clinical trials / health services research (B)
William Ghali, MD, Chair
Gordon Gubitz, MD, Deputy Chair
Margaret L. Rand, PhD
Integrative studies: genetic manipulations / imaging /
bioengineering
Evangelos Michelakis, MD, Chair
Elaine Roper
Think Company Inc.
Richard Frayne, PhD, Deputy Chair
Balwant Tuana, PhD
Chair, Scientific Review Committee
Basic science stroke / neurophysiology / neuroregulation
Tim Murphy, PhD, Chair
Grace Warner, PhD
Phyllis Paterson, PhD, Deputy Chair
Cellular biochemistry, pharmacology and electrophysiology (A)
Christopher Triggle, PhD, Chair
Weill Cornell Medical College, Qatar
Thomas G. Parker, MD, Deputy Chair
St. Michael’s Hospital
136
Cellular biochemistry, pharmacology and electrophysiology (B)
Rhian Touyz, MD, PhD, Chair
2008-2009 Provincial Research
Advisory Committee Chairs
Lucie Parent, PhD, Deputy Chair
Université de Montréal
Heart and Stroke Foundation of British Columbia and Yukon
Research Advisory Committee
Glen F. Tibbits, PhD, Chair
Simon Fraser University
Molecular basis of cardiac and vascular function
Edward O’Brien, MD, Chair
David Granville, PhD, Deputy Chair
St. Paul’s Hospital
Thrombosis / lipids and lipoproteins / fundamental nutrition
research
Richard Lehner, PhD, Chair
Richard Austin, PhD, Deputy Chair
McMaster University
Behavioural research / health psychology / rehabilitation /
population health
Ken Prkachin, PhD, Chair
University of Northern British Columbia
Wendy Rodgers, PhD, Deputy Chair
Senior Personnel (New Investigator / Career Investigator / Visiting
Scientist)
Balwant Tuana, PhD, Chair
Todd Anderson, MD, Deputy Chair
Foothills Hospital
John McGuire, PhD, Chair
Memorial University of Newfoundland
Research Fellowship
Debbie Saucier, PhD, Chair
University of Lethbridge
Heart and Stroke Foundation of Alberta, Northwest Territories
and Nunavut Research and Medical Advisory Committee
Henry J. Duff, MD, Chair
Heart and Stroke Foundation of Saskatchewan Research
Advisory Committee
Noreen Johns, Chair
Heart and Stroke Foundation of Manitoba Research
Advisory Committee
Michelle Nelson, Chair
Heart and Stroke Foundation of Ontario Grant Allocation
Sub-Committee
Geoffrey Pickering, MD, PhD, Chair
London Health Sciences Centre
Heart and Stroke Foundation of Ontario Research Committee
Robert McKelvie, MD, PhD, Chair
Hamilton Health Sciences
Comité scientifique de la Fondation des maladies du coeur
du Québec
Pedro D’Orléans-Juste, PhD, Président
Université de Sherbrooke
Heart and Stroke Foundation of New Brunswick Medical
Advisory Committee
Christopher Loomer, MD, Chair
Heart and Stroke Foundation of Nova Scotia Scientific
Advisory Committee
Marilyn MacKay-Lyons, PhD, Chair
137
138
APPENDIX
H
DEFINITION OF HEALTH RESEARCH THEMES
Photo: Dr. Kim Lavoie (Université du Québec à Montréal) was the recipient in 2008-2009 of a Grant-in-Aid from the Heart and Stroke Foundation of
Québec, titled “CAD risk associated with clinical vs subclinical depression”.
The four themes of health research as defined by the Michael Smith Foundation for Health Research are::
I. Basic Biomedical
Research with the goal of understanding normal and abnormal human function, at the molecular, cellular, organ system, and whole body
levels, including the development of tools and techniques to be applied for this purpose; developing new therapies or devices which
improve health or the quality of life of individuals, up to the point where they are tested on human subjects. Studies on human subjects
that do not have a diagnostic or therapeutic orientation.
II. Clinical
Research with the goal of improving the diagnosis and treatment (including rehabilitation and palliation) of disease and injury; improving
the health and quality of life of individuals as they pass through normal life stages. Research on, or for the treatment of, patients.
III. Health Services/Systems
Research with the goal of improving the efficiency and effectiveness of health professionals and the health care system, through
changes to practice and policy. Health services research is a multidisciplinary field of scientific investigation that studies how social
factors, financing systems, organizational structures and processes, health technologies, and personal behaviours affect access to health
care, the quality and cost of health care, and ultimately our health and well-being.
IV. Population Health
Research with the goal of improving the health of the Canadian population, or of defined sub-populations, through a better
understanding of the ways in which social, cultural, environmental, occupational, and economic factors determine status.
140
To find more information about heart disease, stroke, how
to live a healthy life, as well as how you can offer much
needed support in your community, visit
www.heartandstroke.ca
or call
1-888-HSF-INFO (1-888-473-4636)
www.hsf.ca/research

2008 - 2009

Transcription

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