final programme
Transcription
final programme
FINAL PROGRAMME 22nd INTERNATIONAL CONGRESS ON THROMBOSIS Acropolis NICE FRANCE 6-9 October 2012 www.medleague-thrombosis.org www.thrombosis2012.org Committees Speakers CONGRESS EXECUTIVE COMMITTEE Walter Ageno Cedric Hermans President Jean-François Schved (Montpellier, France) University of Insubria, Clinical and experimental Medicine Department. Varese, Italy Cliniques Universitaires Saint-Luc. Division of Haematology. Bruxelles, Belgium Pierre Albaladejo Jean Pierre Laroche Vice-President Jacqueline Conard (Paris, France) Ismaïl Elalamy (Paris, France) Françoise Dignat-George (Marseille, France) Emile Ferrari (Nice, France) Thomas Lecompte (Nancy, France) Patrick Mismetti (Saint-Etienne, France) Isabelle Quéré (Montpellier, France) Christine Biron-Andréani (Montpellier, France) Honorary President Meyer-Michel Samama (Paris, France) COUNCIL OF THE MEDITERRANEAN LEAGUE AGAINST THROMBOEMBOLIC DISEASES· EXECUTIVE BOARD President Pier M. Mannucci Past President Christos Liapis General Secretary Maria Teresa Santos Members Meyer-Michel Samama Jacqueline Conard Paolo Prandoni David Varon COUNTRY COUNCILLORS I.B. Topalov (Bulgaria) Ana Bronic (Croatia) Andrew Nicolaides (Cyprus) Nevine Kassim (Egypt) Jacqueline Conard (France) Ismaïl Elalamy (France) Antonios Hatzizacharias (Greece) Anthi Travlou (Greece) Uri Seligsohn (Israel) David Varon (Israel) Maria Benedetta Donati (Italy) Paolo Prandoni (Italy) Ali Taher (Lebanon) Cherif Abdelkhirane (Morocco) Zoubida Tazi (Morocco) Manuel Campos (Portugal) Luis Manuel Cunha-Ribeiro (Portugal) Abdul Kareem Al Momen (Saudi Arabia) Ivo Elezovic (Serbia) Mojca Stegnar (Slovenia) Amparo Estellés (Spain) Maria Teresa Santos (Spain) Lina Badimon (Spain) Sami Guermazi (Tunisia) Turgut Ulutin (Turkey) Mehmet Nejat Akar (Turkey) Grenoble, France Juan Ignacio Arcelus Martínez Universidad de Granada, Surgery Department. Granada, Spain Jean-François Arnal CHU, Faculté Médicine et Université de Toulouse III. Paris, France Lina Badimon Cardiovascular Research Center, CSIC-ICCC. Barcelona, Spain Ángeles Blanco Molina Hospital Reina Sofía, Internal Medicine Department. Córdoba, Spain Chantal M. Boulanger Paris Cardiovascular Research Center, Inserm UMR970. Paris, France Marie-Germaine Bousser CHU Montpellier, Vascular Medicine Department. Montpellier, France Grégoire Le Gal CHRU de la Cavale Blanche, Département de medicine interne et de pneumologie. Ottawa, Canada Jean-Yves Le Heuzey Hôpital Européen Georges Pompidou, Cardiologie et Rythmologie. Paris, France Thomas Lecompte CHU de Nancy-Hospital de Brabois Service d’Hámtologie Biologique. Nancy, France Xavier Leleu Service des maladies du sang, Hopital Huriez. Lille, France Mario Mandala Department of Oncology and Haematology. Ospedali Riuniti Bergamo, Italy Hôpital LARIBOISIERE. Neurology Department. Paris, France Patrick Mismetti Margareth Castro Ozelo Rienk Nieuwland University of Campinas (UNICAMP), Hematology Department (Hemocentro UNICAMP). Campinas, Brazil Marco Cattaneo Università degli Studi di Milano, Dipartimento della Salute. Milano, Italy Jacques Chiaroni Marseille, France Ariel Cohen Paris, France Jean-Philippe Collet Groupe Hospitalier Pitié-Salpetrierè. Paris, France Francis Couturaud Cavale Blanche Hospital. Internal Medicine and Chest Diseases Department. Brest, France Ola E. Dahl Thrombosis Research Institute. London, UK. Bas de Laat Biochemitry, CARIM. Maastricht, The Netherlands Katrien Devreese Gent University Hospital. Coagulation Laboratory Department. Ghent, Belgium Christophe Dubois Faculty of Medicine La Timone. Marseille, France Charles T. Esmon Howard Hughes Medical Institute/ Oklahoma Medical Research Foundation, Coagulation Biology Laboratory. Oklahoma, USA Anna Falanga Ospedali Riuniti of Bergamo, Inmmunohematology and Trasfusion Medicine Department. Bergamo, Italy Pierre Fontana University Hospital Geneva. Angiology and Haemostasis Department. Geneva, Switzerland Bruce Furie Harvard Medical School. Harvard, USA Muriel Giansily-Blaizot CHU of Montpellier (Hôpital Saint Eloi), Hématologie Biologique Department. Montpellier, France Augustin Hellmut German Cancer Research Center, Vascular Oncology and Metastasis Research Department. Heidelberg, Germany Saint-Etienne, France Academic Medical Centre of the University of Amsterdam. Clinical Chemistry Department . Amsterdam, The Netherlands Mette Nørgaard Aarhus University Hospital, Clinical Epidemiology Department, Aarhus, Denmark Vittorio Pengo Clinica Cardiologica, Centro Trombosi. Dipartmento di Scienze Cardiologiche Toraciche e Vascolari.Università degli Studi di Padova, Italy Geneviève Plu-Bureau Paris, France Thomas Renné Karolinska Institute and Universitz Hospital, Molecular Medicine and Surgerz Department. Stockholm, Sweden Wolfram Ruf The Scripps Research Institute. Immunology and Microbial Science Department. La Jolla, U.S.A. Charles Marc Samama Cochin University Hospital. Anaesthesia and Intensive care Department. Paris, France Meyer Michel Samama BIOMNIS LABORATORIES, R&D Department. Ivry, France Stephanie Schultz Cardiology,German Heart Center Munich, Germany Jean-Sébastien Silvestre Inserm U970, Paris Cardiovascular Research Center. Paris, France Regine Sitruk-Ware Population Council, Center for Biomedical Research. New York, USA Armando Tripodi University of Milano, Internal Medicine Department. Milano, Italy David Varon Hadassah-Hebrew University Medical Center, Hematology Department. Jerusalem, Israel Chairmen Ulrich Abildgaard Amparo Estelles Centro de Investigación Hospital Universitario La Fe Valencia, Spain Charles Marc Samama Oslo University Hospital. Oslo, Norway Essam AboelNazar Anne Marie Fischer Laboratoire d’hématologie. Hôpital Européen Georges POMPIDOU. Paris, France Per Morten Sandset UmQ University. Jeddah, Saudi Arabia Anat Aharon Denis Gerard Wahl Lorraine University. Nancy, France Maria Teresa Santos Rambam Health Care Campus. Haifa, Israel Nejat Akar Grigoris Gerotziafas Cochin University Hospital. París, France Oslo University Hospital Rikshospitalet. Oslo, Norway University Hospital La Fe. Valencia, Spain Hôpitaux Universitaires Est Parisien, Assistance Publique Hôpitaux de Paris. Faculté de médecine Pierre et Marie Curie, Université Paris VI. Paris, France Uri Seligsohn College of Medicine & KKUH, King Saud University. Riyadh, Saudi Arabia Emna Gouider Virginie Siguret Depasse Ana Bronic Isabelle Gouin-Thibault TOBB-ETU Hospital. Ankara, Turkey Abdulkareem Almomen Tunisia Chaim Sheba Medical Center. Tel Hashomer, Israel MCU-PH, Hôpital Européen Georges Pompidou. Paris, France Traumatology Clinic, Clinical Hospital Centre ´Sestre Milosrdnice´. Zagreb, Croatia Université Paris Descartes. Paris, France Mojca Stegnar Sergio Coccheri Sami Guermazi Hôpital Charles Nicolle de Tunis, Tunisia Pierre Toulon University of Bologna, Italy Jacqueline Conard Job Harenberg Anthi Travlou Hotel-Dieu. Paris, France Ola E. Dahl Innlandet Hospital Trust and Thrombosis Research Institute. Kolsås, Norway Hervé Decousus Centre d’Investigation Clinique CIE3 (INSERM/DHOS). Hôpital Nord CHU ST ETIENNE. Saint-Étienne, France Francesco Dentali Insubria University, Varese, Italy Françoise Dignat-George INSERM UMR 608, UFR de Pharmacie, Campus Timone Marseille, France Maria Benedetta Donati Fondazione di Ricerca e Cura “Giovanni Paolo II” CAMPOBASSO, Italy Sabine Eichinger Medical University of Vienna Austria, Viena Ismaïl Elalamy Hôpitaux Universitaires Paris-Est. Breullet, France Ginés Escolar Hospital Clinic. Barcelona, Spain Charles T. Esmon Howard Hughes Medical Institute/ Oklahoma Medical Research Foundation, Coagulation Biology Laboratory. Oklahoma, USA. Clinical Pharmacology, Medical Faculty Mannheim, University of Heidelberg Mannheim, Germany Nevine Kassim Ain Shams University, Faculty of Medicine. Heliopolis, Cairo. Egypt Silvy Laporte MCU-PH Pharmacologie Clinique, Hôpital Nord. Université Jean-Monnet. Saint-Etienne, France Thomas Lecompte Hopitaux Universitaires de Geneve. Nancy, France Pier M. Mannucci IRCCS Ca’ Granda Maggiore Policlinico Hospital Foundation. Milan, Italy Patrick Mismetti Hôpital Nord. Saint-Etienne, France Pierre-Emmanuel Morange INSERM, UMR_S 626, Université de la Méditerranée, CHU Timone. Marseille, France Paolo Prandoni Clinica Medica 2, University of Padova, Italy Meyer Michel Samama BIOMNIS LABORATORIES. Ivry-Sur-Seine Cedex, France Ljubljana, Slovenia France Athens, Greece Armando Tripodi University of Milano. Milan, Italy Turgut Ulutin Cerrahpasa Medical Faculty. Instanbul, Turkey Juana Vallés Hospital La Fe. Valencia, Spain David Varon Hadassah-Hebrew University Medical Center. Jerusalem, Israel. Tazi Mezalek Zoubida Ibn Sina Hospital. Rabat, Morocco Acknowledgements On behalf of the Mediterranean League against Thromboembolic Diseases (MLTD), we take great pleasure in inviting you to attend the 22nd International Congress on Thrombosis in Nice (October 6-9, 2012). Nice has been chosen for the venue of this meeting because of its location on the Mediterranean Sea, its dynamic university and its accessibility. The Congress Centre, Acropolis, is an attractive place in downtown Nice with a modern and functional structure. The most important is the program of the sessions, combining both clinical and biological aspects of thrombosis which is the aim of MLTD congresses. We have planned plenary sessions, symposia and educational sessions on up-to-date subjects, all presented by outstanding lecturers. In addition, we trust on your willing to send abstracts on original new findings. New antithrombotics, antiplatelet agents and anticoagulants, are now available. Their mode of action, indications, doses and side-effects need to be clarified, as well as their influence on laboratory tests. In 2012, the importance of ‘old’ antithrombotics such as aspirin, clopidogrel, vitamin K antagonists and heparins shall be considered. The guidelines have been published in different countries for a treatment and prevention of thrombosis: they must be known and followed by clinicians in the real life. New approaches based on cellular interactions, proteomics and genomics will be presented and discussed. Women’s Health also is a major topic. Pregnancy, hormonal treatments for contraception, menopause and breast cancer can increase the risk of thrombosis, and the most recent area impacts all assisted reproductive technologies. Other innovative themes on the latest research will be developed. We hope many of you will attend this congress and we look forward to welcoming you for a very ‘Nice’ meeting. President Jean-François Schved Vice-President Jacqueline Conard General information VENUE ELECTRONIC DEVICES Nice Acropolis (Palais des Congrès) 1, Esplanade Kennedy - BP 4083 06302 Nice Cedex 4, France BUSINESS CENTRE CONTINUING MEDICAL EDUCATION This programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for 15 hours of external CME credits. Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works according to the quality standards of the European Accreditation Council for Continuing Medical Education (EACCME), which is an institution of the European Union of Medical Specialists (UEMS). In compliance with EBAC/ EACCME guidelines, all speakers/ chairpersons participating in this programme have disclosed or indicated potential conflicts of interest, which might cause a bias in the presentations. The Organizing Committee/Course Director is responsible for ensuring that all potential conflicts of interest relevant to the event are declared to the audience prior to the CME activities. BADGE Each participant will receive a name badge upon check-in at the Registration Desk. The badge will be considered as an official meeting document and should be carried all the time in order to get granted access to the meeting rooms. GALA DINNER The Gala Dinner will take place on Hotel Palais de la Mediterranée 13, promenade des Anglais, 06011 Nice To attend the gala dinner, do not forget to bring your ticket or invitation. Without it, the access to the restaurant will be denied. The Gala Dinner will start at 20:30 hs. We kindly ask all participants for being on time. REGISTRATION DESK The registration desk is located in the Main Hall in front of the entrance and it will be open on: Saturday October 6th 12:00 - 18:30 Sunday October 7th 07:30 - 18:30 Monday October 8th 07:30 - 18:30 Tuesday October 9th 08:00 - 15:30 PREVIEW ROOM The preview room is located on the Hermes Foyer near the Hermes Auditorium. All speakers should check and deliver their PowerPoint presentations to the Preview Room at least 4 hours before the start of the session or the day before for early morning sessions. Saturday October 6th 11:00 - 18:30 Sunday October 7th 07:30 - 17:00 Monday October 8th 07:30 - 18:20 Tuesday October 9th 07:30 - 14:00 CLOAKROOM - OPENING HOURS Saturday October 6th 11:30 - 21:00 Sunday October 7th 07:30 - 17:30 Monday October 8th 07:30 - 18:45 Tuesday October 9th 08:30 - 15:30 As a courtesy to your colleagues, we invite you to turn off or silence all electronic devices during the educational, plenary sessions and symposiums. A Business Centre with computer facilities is available on the first floor, in the exhibitor area. WIFI Internet access is available through WIFI connection in the Business Centre and in the exhibitor area. CATERING FACILITIES Lunch boxes will be served in the exhibitor area, at the time specified in the programme. Coffee breaks will be also provided during the Congress. MEANS OF TRANSPORT Airport The Nice Côte d’Azur Airport is France’s second-largest international airport. It is located 15 minutes from the Acropolis (7 km from the city centre). More than 50 airlines provide regular service to destinations throughout the world. An 80-minute flight links Nice to Paris, and is offered 23 times a day. http://en.nice.aeroport.fr Bus and tramway The transport network «Ligne d’azur» proposes a single rate on the whole Urban Community of Nice Côte d’Azur which includes 24 municipalities. The proposed rate is fixed at 1euro both for the transport network by bus and by tram. Azur n°: +33 (0)810 061 006 (price local call) www.tramway-nice.org www.lignedazur.com « Vélos bleus » bikes 900 bikes are available in 90 stations distributed all over the city. Rates are established as follow: - The first half an hour: free access (Subject to subscription) - Between ½ an hour and 1 hour: 1 € - Additional hour: 2 € per additional hour Azur n°: +33 (0)810 061 006 (price local call) Or: +33 (0)4 93 72 06 06 www.velobleu.org Taxis The customers have to pay only the price shown on the meter of taxis. It is strongly recommended to the customers to require a receipt on behalf of the taxi drivers. Central reservations office n°: +33 (0)4 93 13 78 78 Programme at a Glance Saturday October 6th AUDITORIUM 1 ATHÉNA AUDITORIUM 2 HERMÈS 12:00 Sunday October 7th AUDITORIUM 3 RHODES Registration 08:30-09:10 Educational Sessions 14:00-15:00 New oral anticoagulant treatments: the role of laboratory Life threatening Methology and perioperative statistics : How to interprete a clinical bleeding assay 15:30-16:30 Which antiplatelet agent for whom? Formation of the clot 16:30-17:00 Circulating biomarkers 09:10-09:45 10:00-11:00 11:00-11:30 11:30-12:40 Break Opening ceremony 12:45-14:15 17:00-17:30 Welcome 17:30-18:15 Plenary Lecture: The origins of mediterranean population determined by molecular anthropology 18:45-19:45 Concert Soloist Bouzouki: Nicolas Syros Title: Canto General Orchestra and choirs: Les Chants de Thau Poems: Pablo Neruda; Music: Mikis Theodorakis Direction: Antoine Alleman 14:15-14:45 19:50-21:00 Welcome Cocktail animated by Nicolas Syros with his musicians Greek contemporary music 08:30-09:45 Women's health 10:00-11:00 11:00-11:30 AUDITORIUM 2 HERMÈS Scientific Symposia Thrombosis in patients with hemorrhagic disorder Oral Communications Coffee Break Plenary Sessions 11:30-12:10 Tissue factor and cancer 12:10-12:40 New insights in atrial fibrillation 13:45-14:30 Lunch Break 14:30-15:30 Hot Topic Session 2 15:30-17:00 Oral Communications Plenary Sessions 17:00-17:40 New insights into the contact activation system 17:40-18:20 Angiogenesis GALA DINNER AUDITORIUM 3 RHODES Unusual thrombosis sites New Anticoagulants Break Plenary Sessions 14:50-15:30 New oral anticoagulant treatments in deep vein thrombosis 15:30-16:15 New insights in atrial fibrillation 16:20-17:50 Hot Topic Session 1 Tuesday October 9th Monday October 8th AUDITORIUM 1 ATHÉNA AUDITORIUM 1 AUDITORIUM 2 ATHÉNA HERMÈS Plenary Sessions Mechanisms of variability in antiplatelet agents response New antiplatelet agents: the end of resistance ? Oral Communications Coffee Break Scientific Symposia Thrombosis after surgical Thrombosis and procedures cancer: prevention and treatment Satellite Symposia Changing landscape in anticoagulation – new perspectives and treatment strategies (12:45-13:45) AUDITORIUM 1 ATHÉNA AUDITORIUM 3 RHODES Microparticules 08:30-09:45 Antiphospholipid antibodies 10:00-11:15 11:15-11:45 AUDITORIUM 2 HERMÈS Scientific Symposia Drug-induced thrombosis AUDITORIUM 3 RHODES Antithrombotic agents and invasive procedures Oral Communications Coffee Break Plenary Sessions 11:45-12:20 What did we learn from new oral anticoagulant treatment? 12:20-13:00 Endothelial progenitor cells and therapeutic angiogenesis 14:00-15:30 Oral Communications ROOM GALLIENI 5 POSTER SESSION 17:50-18:30 Sunday October 7th 12:45-13:45 Monday October 8th 13:00-14:00 Tuesday October 9th Sunday October 7th Councillors and 13:00-14:30 Foundation Meeting Monday October 8th 12:45-13:45 General Assembly Scientific Programme Sunday October 7th Saturday October 6th 12:00 Registration 14:00 - 16:30 Educational Sessions 14:00 - 15:00 First session New oral anticoagulant treatments: the role of laboratory (Auditorium Athéna) Armando Tripodi Meyer Michel Samama Methology and statistics: How to interprete a clinical assay (Auditorium Hermès) Patrick Mismetti Life threatening perioperative bleeding (Auditorium Rhodes) Charles Marc Samama 15:30 - 16:30 Second session 15:30-16:30 Which antiplatelet agent for whom? (Auditorium Athéna) Ariel Cohen Formation of the clot (Auditorium Hermès) Bruce Furie Circulating biomarkers (Auditorium Rhodes) Lina Badimon 16:30-17:00 17:00-17:30 Break Opening ceremony (Auditorium Athéna) Welcome Jean Francois Schved, President of the Congress Pier M. Mannucci, President of the MLTD Meyer Michel Samama, Honorary President of the Congress 17:30-18:15 Plenary Lecture: The origins of mediterranean population determined by molecular anthropology Jacques Chiaroni 18:45-19:45 Concert Soloist Bouzouki: Nicolas Syros Title: Canto General Orchestra and choirs: Les Chants de Thau Poems: Pablo Neruda; Music: Mikis Theodorakis Direction: Antoine Alleman 19:50-21:00 Welcome Cockatil animated by Nicolas Syros with his musicians Greek contemporary music 08:30-09:45 Plenary Session (Auditorium Athéna) Chair: María Teresa Santos 08:30-09:10 Mechanisms of variability in antiplatelet agents response Marco Cattaneo 09:10-09:45 New antiplagents agents: the end of resistance? Stephanie Schultz 10:00-11:00 Oral Communications (CO1, CO2, CO3) CO1: New oral antithrombotics (Auditorium Athéna) Chairs: Patrik Mismetti and Ola E. Dahl C0126 VALUE-BASED PRICING FOR DABIGATRAN, RIVAROXABAN AND APIXABAN IN PATIENTS WITH NONVALVULAR ATRIAL FIBRILLATION IN GERMANY Martin Krejczy, Svetlana Marx, Konrad Obermann, Martin Wehling, Job Harenberg C0131 COMPARISON OF THE EFFICACY AND SAFETY OF DABIGATRAN, RIVAROXABAN AND APIXABAN IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION USING NETWORK META-ANALYSIS Svetlana Marx, Job Harenberg, Martin Wehling, Christel Weiss, Hans-Christoph Diener, Victor J. Marder, Gregory Y.H. Lip C0227 INDIRECT COMPARISON OF THE EFFICACY AND SAFETY OF DABIGATRAN, RIVAROXABAN AND APIXABAN IN ELECTIVE TOTAL KNEE AND HIP REPLACEMENT SURGERY Svetlana Marx, Christel Weiss, Martin Wehling, HannsPeter Scharf, Ola Dahl, Job Harenberg C0295 MEASUREMENT OF DABIGATRAN AND RIVAROXABAN IN PRIMARY PREVENTION OF VENOUS THROMBOEMBOLISM IN 106 PATIENTS, WHO HAVE UNDERGONE MAJOR ORTHOPEDIC SURGERY. AN OBSERVATIONAL STUDY Samama Meyer Michel, Guinet Celine, Le Flem Lena, Ninin Emmanuel, Debue Jean-Marc CO2: Platelets (1) (Auditorium Hermès) Chairs: Anthi Travlou and Mojca Stegnar C0195 THE PRESENCE OF THE TXA2 RECEPTOR IN LIPID RAFTS OF PLATELETS IS NECESSARY FOR PLATELET ACTIVATION BY TXA2 Antonio Moscardó, Juana Vallés, Isabel Madrid, Ana Latorre, Ángeles Dasí, María Teresa Santos C0188 THE ACETYLATION OF TUBULIN REGULATES DENSE GRANULE RELEASE IN HUMAN PLATELETS Antonio Moscardó, María Teresa Santos, Ana Latorre, Isabel Madrid, Juana Vallés C0343 POLYMORPHISMS OF PROTEIN TYROSINE PHOSPHATASE CD148 INFLUENCE FCGAMMARIIA-DEPENDENT PLATELET ACTIVATION AND THE RISK OF HEPARIN-INDUCED THROMBOCYTOPENIA Rollin Jerome, Pouplard Claire, Gratacap Marie-Pierre, Leroux Dorothee, Aupart Michel, May Marc-Antoine, Gouilleux-Gruart Valerie, Payrastre Bernard, Gruel Yves CO3: Fibrinogen (Auditorium Rhodes) Chairs: Pierre Toulon and Ana Bronic C0113 IMPACT OF DIRECT THROMBIN AND DIRECT F XA INHIBITOR ANTICOAGULANTS ON ACL TOP FAMILY FIBRINOGEN ASSAYS Janet Callahan, Karen DiStasio, Denise Matte, Mary Doyle, Mark Triscott, Philippe Lacombe C0260 MUTATION IN FIBRINOGEN POLYMERIZATION POCKET ASSOCIATED WITH THROMBOSIS 12:45-14:15 New Anticoagulants Chair: Yves Gruel Roman Kotlin, Jiri Suttnar, Kristyna Pimkova, Vera Geierova, Jan Evangelista Dyr C0096 ASSESSING THE COMBINED EFFECTS TWO SINGLE NUCLEOTIDE GENETIC POLYMORPHISMS OF FIBRINOGEN GENES ON THE COAGULATION CASCADE IN PATIENTS WITH STABLE ANGINA 12:45 Zoi Pallantza, Stavros Kontos, Maria Kozanitou, Stilianos Gratsias, Athanasia Lazaraki, Maria Eleni Mplouna, Nikolaos Papageorgiou, Dimitrios Tousoulis, Antigoni Miliou, Christodoulos Stefanadis, Zoi Pallantza Welcome and Introduction Yves Gruel 12:50 Pharmacology of new anticoagulants: the key aspects Armando D’Angelo C0127 EVALUATION OF NEW AUTOMATIZED SOLUBLE FIBRIN/FIBRIN MONOMER METHOD 13:15 Effects of noacs on hemostasis: practical consequences for the biologist Carlos Aguilar Coffee Break 13:45 Management of patients treated with noacs in emergent clinical situations Yves Gruel 14:10 Concluding Remarks Yves Gruel Eli Westerlund, Jaak Eintrei, Lisbeth Söderblom, Jovan P Antovic 11:00-11:30 11:30-12:40 Satellite Symposia (Auditorium Rhodes) Scientific Symposia Thrombosis after surgical procedures (Auditorium Athéna) Chairs: Charles Marc Samama and Virginie Siguret Asymptomatic distal DVT is not a surrogate end-point Charles Marc Samama Bleeding definitions in orthopaedic VTE prophylaxis trials: a real need for standardization Ola E. Dahl Should we follow the 9th ACCP guidelines? Juan Ignacio Arcelus Martínez Thrombosis and cancer: prevention and treatment (Auditorium Hermès) Chairs: Ismail Elalamy and Abdulkareem Almomen Aspirin and colorectal cancer Christophe Dubois Multiple myeloma: epidemiology and risk factors Xavier Leleu Thrombosis during myeloma: prevention and treatment Grégoire Le Gal 13:00-14:30 14:15-14:45 Plenary Session (Auditorium Athéna) Chair: Meyer Michel Samama 14:50-15:30 New oral anticoagulant treatments in deep vein thrombosis Pierre Fontana 15:30- 16:15 Thrombosis in hematologic malignancies Anna Falanga 16:20-17:50 12:45-13:45 Changing landscape in anticoagulation – new perspectives and treatment strategies Laporte Silvy, Mismetti Patrick, Chapelle Céline, Bertoletti Laurent, Merah Adel, Lega Jean-Christophe, Décousus Hervé C0346 ARE PATIENTS EXPOSED TO ANTIPSYCHOTICS TRULY AT RISK OF VENOUS THROMBOEMBOLISM? Céline Chapelle, Sara Quenet, Xavier Delavenne, Karine Lacut, Patrick Mismetti, Silvy Laporte, Marie-Noëlle Beyens C0416 HIGH LIPOPROTEIN(A) AND HOMOCYSTEINE LEVELS ARE ASSOCIATED TO THE EXTENSION OF ATHEROSCLEROTIC DISEASE IN ACUTE CORONARY SYNDROME PATIENTS. Gabriele Cioni, Rossella Marcucci, Serafina Valente, Cristina Giglioli, Rosanna Abbate, Maria Boddi C0419 IS PROTHROMBIN TIME A PREDICTOR OF NEW-ONSET DIABETES IN HYPERTENSIVE AND CORONARY HEART DISEASE PATIENTS? Gwo-Ping Jong, Tsochiang Ma 12:45 WELCOME & INTRODUCTION Chair: Patrick Mismetti 12:50 NOVEL ANTICOAGULANTS – NEW PERSPECTIVES IN ATRIAL FIBRILLATION José Luis Zamorano C0213 FIGHTING FOR ACUTE PULMONARY EMBOLISM IN RUSSIA 13:05 CURRENT LANDSCAPE OF VENOUS THROMBOEMBOLISM – THE CLINICIAN’S VIEW Patrick Mismetti 13:25 NEW DIRECTIONS IN VENOUS THROMBOEMBOLISM MANAGEMENT Walter Ageno 13:35 PANEL DISCUSSION & MEETING CLOSE All HOT TOPICS SESSION 1 (Auditorium Hermès) Chairs: Silvy Laporte and Sergio Coccheri C0313 CLINICALLY RELEVANT NON-MAJOR BLEEDING: A SURROGATE ENDPOINT FOR MAJOR BLEEDING? VALIDATION BY META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS IN MAJOR ORTHOPEDIC SURGERY, VENOUS THROMBOEMBOLIC TREATMENT AND ATRIAL FIBRILLATION Cerebral venous thrombosis, pregnancy and contraception Marie-Germaine Bousser Splanchnic thrombosis Walter Ageno Mondor disease Jean-Pierre Laroche Satellite Symposia (Auditorium Hermès) BREAK 14:50-16:15 Unusual thrombosis sites (Auditorium Rhodes) Chairs: Uri Seligsohn and Tazi Mezalek Zoubida 12:45-13:45 Councillors and Foundation Meeting (Room Gallieni 5) Igor Bokarev, Aleksandr Medvedev C0016 INTERNATIONAL GOOD CLINICAL PRACTICES (GCP) GUIDELINES FOR ANTITHROMBOTICS IN CANCER PATIENTS D Farge-Bancel, P Debourdeau 17:50-18:30 Posters Session (PS1) (Foyer) Monday October 8th 08:30-09:45 Scientific Symposia 08:30-09:45 Women's health (Auditorium Athéna) Chairs: Jacqueline Conard and Per Morten Sandset CO5: Platelets (2) (Auditorium Hermès) Chair: Thomas Lecompte C0166 THE RELATIONSHIP BETWEEN PLATELET GLYCOPROTEIN IIB RS5911 POLYMORPHISM AND INFLAMMATION IN COPD PATIENTS Hilal Altinoz, Samet Ergun, Koray Ak, Zehra Oya Uyguner, Turay Yardimci, Sermin Tetik Estrogens and cardiovascular risk in menopausal women: benefit or harm? Jean-François Arnal Estrogens, progestins, estrogenicity and new contraceptions Regine Sitruk-Ware Contraception, venous thrombosis and biological plausability Geneviève Plu-Bureau C0363 DISCOID PLATELET AGGREGATIONS VISUALIZED BY IN VIVO MOLECULAR IMAGING, AND CONTRIBUTION OF INFLAMMATORY CYTOKINES Satoshi Nishimura, Mika Nagasaki, Ryozo Nagai C0347 THROMBIN BINDING TO PLATELETS OF YOUNG PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION Grazia Loredana Mendolicchio, Monica Bacci, Dennis Zavalloni, Lidia Rota, Zaverio Marcello Ruggeri Thrombosis in patients with hemorrhagic disorder (Auditorium Hermès) Chairs: Emma Gouider and Paolo Prandoni C0063 DOWN REGULATION OF PLATELET ACTIVATION MARKERS DURING LONG-TERM IMMOBILIZATION Thrombosis during PTI Mette Nørgaard Thrombosis in factor VII deficiency Muriel Giansily Blaizot Thrombosis in haemophiliacs Cedric Hermans Surgery in hemophiliacs: is thromboprophylaxis mandated? Margareth Castro-Ozelo Karin Arinell, Ole Fröbert, Stéphane Blanc, Anders Larsson, Kjeld Christensen CO6: Perinatal and pediatric hemostasis (Auditorium Rhodes) Chairs: Nejat Akar and Pierre-Emmanuel Morange C0160 NEONATAL THROMBOSIS: INFLUENCE OF ETHNICITY ON GENETIC RISK FACTORS Carina Levin, M. Peniakov, C. Felszer, D. Reich, S Shalev, Ariel Koren Microparticules (Auditorium Rhodes) Chairs: Françoise Dignat-George and Anat Aharon C0240 SAFETY AND EFFICACY OF ANTICOAGULATION IN CEREBRAL SINUS THROMBOSIS IN CHILDREN: A SINGLE CENTER EXPERIENCE Microparticles in vascular disorders Rienk Niewland Microparticles, endothelial dysfunction and atherothrombosis Chantal Boulanger Microparticles, angiogenesis and cancer David Varon 10:00-11:00 Angeles Dasi, Sara Izquierdo, Bienvenida Argiles C0369 FACTOR V LEIDEN AND PROTHROMBIN 20210A MUTATIONS AMONG TURKISH PEDIATRIC LEUKEMIA PATIENTS Dilara Fatma Akin, Kadir Sipahi, Tuğba Kayaalp, Yonca Eğin, Serpil Taşdelen, Emin Kürekçi, Üstün Ezer, Nejat Akar Oral Communications (CO4, CO5, CO6) C0382 THE ROLE OF THROMBOPHILIA IN THE PERINATAL STROKE IN NEONATES: A RETROSPECTIVE STUDY IN 54 CASES CO4 : New oral anticoagulants (Auditorium Athéna) Chairs: Gines Escolar and Job Harenberg C0122 EFFECTS OF APIXABAN ON HEMOSTASIS AND REVERSAL OF ITS ANTICOAGULANT ACTION BY DIFFERENT COAGULATION FACTOR CONCENTRATES: STUDIES IN VITRO WITH CIRCULATING HUMAN BLOOD Gines Escolar, Eduardo Arellano-Rodrigo, Juan Carlos Reverter, Jaume Villalta, Victoria Veronica Sanz, Patricia Molina, Maribel Diaz-Ricart, Ana Maria Galan C0139 REVERSAL OF RIVAROXABAN-INDUCED PROLONGATION OF CLOTTING TIME WITH PROTHROMBIN COMPLEX CONCENTRATE (PCC), ACTIVATED PROTHROMBIN COMPLEX CONCENTRATE (APCC) AND RECOMBINANT FACTOR VIIA (RFVIIA) IN VITRO Elizabeth Perzborn, Stefan Heitmeier, Volker Laux C0190 INFLUENCE OF AGE AND RENAL FUNCTION ON THE CONCENTRATION OF RIVAROXABAN IN PLASMA AND URINE IN PATIENTS UNDERGOING PRIMARY ELECTIVE TOTAL KNEE AND HIP REPLACEMENT SURGERY Astrid Schulze, Svetlana Marx, Christel Weiss, Job Harenberg C0353 UNITED KINGDOM CONSENSUS BASED PRACTICAL GUIDE FOR THE MANAGEMENT OF HAEMORRHAGE IN PATIENTS RECEIVING DABIGATRAN Raza Alikhan, Rachel Rayment, Trevor Baglin, Gary Benson, Laura Green, David Keeling, Scott Marshall, Raj Patel, Sue Pavord, Peter Rose, Campbell Tait M. Luciani, M. Balestri, K. Girardi, L. Altomare, M. Soldati, S. Pancotti, A. Minozzi, G. Avvisati, F. Locatelli 11:00-11:30 Coffee Break 11:30-12:40 Plenary Session (Auditorium Athéna) Chair: Maria Benedetta Donati 11:30-12:10 Tissue factor and cancer Wolfram Ruf 12:10-12:40 New insights in atrial fibrillation Jean-Yves Le Heuzey 12:45-13:45 General Assembly (Room Galliani 5) 12:45-13:45 Posters session (PS2) (Foyer) 13:45-14:30 14:30-15:30 Lunch Break Hot Topic Session 2 (Auditorium Hermès) Chair: Hervé Decousus and Francesco Dentali C0427 SYSTEMATIC REVIEW AND PATIENT-LEVEL METAANALYSIS: RESIDUAL VENOUS OBSTRUCTION TO PREDICT RECURRENCE OF VENOUS THROMBOEMBOLISM AFTER UNPROVOKED DEEP VEIN THROMBOSIS Marco Paolo Donadini, Walter Ageno, Benilde Cosmi, Gregory Le Gal, Daniela Poli, Paolo Prandoni, Marco Rodger, Sergio Siracusa, Laura Young, Matteo Bonzini, Monica Caprioli, Francesco Dentali, Alfonso Dorio, James Douketis C0413 LACK OF ASSOCIATION BETWEEN BLOOD VISCOSITY AND THROMBOTIC EVENTS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. C0386 A META-SYNTHESIS OF QUALITATIVE STUDIES EXPLORING PATIENTS’ AND HEALTHCARE PROFESSIONALS VIEWS OF ATRIAL FIBRILLATION AND ORAL ANTICOAGULANT THERAPY A. Vayá, E. Bonet, C. Alcalá, JM. Ricart Christian Borg Xuereb, Rachel L. Shaw, Gregory Y.H. Lip, Deirdre A. Lane C0060 CHRONIC OBSTRUCTIVE PULMONARY DISEASE IS NOT ASSOCIATED WITH FUTURE RISK OF VENOUS THROMBOEMBOLISM IN A GENERAL POPULATION - THE TROMSØ STUDY C0265 ELEVATED HOMOCYSTEINE LEVELS ARE ASSOCIATED WITH SYSTEMIC ATHEROSCLEROSIS IN PATIENTS WITH ACUTE CORONARY SYNDROME. Trond Børvik, Sigrid K. Brækkan, Hasse Melbye, JohnBjarne Hansen Gabriele Cioni, Rossella Marcucci, Elisabetta Cappellini, Rosanna Abbate, Maria Boddi C0250 THE APS PIEDMONT COHORT: APL PROFILE AND RISK FACTORS FOR THROMBOTIC RECURRENCES C0129 EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS IN ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE LITERATURE Mario Bazzan, Antonella Vaccarino, Stefania Stella, Renato Carignola, Maria Tiziana Bertero, Barbara Montaruli, Dario Roccatello 15:30-17:00 Francesco Dentali, Nicoletta Riva, Mark Crowther, Alexander Turpie, Gregory Lip Oral Communications (CO7, CO8, CO9) CO7: Antivitamin K (Auditorium Athéna) Chairs: Armando Tripodi and Isabelle Gouin-Thibault C0090 CAROTID ATHEROSCLEROSIS AND FUTURE RISK OF VENOUS THROMBOEMBOLISM AND MYOCARDIAL INFARCTION - THE TROMSØ STUDY C0310 RISK STRATIFICATION MODELS TO PREDICT BLEEDING EVENTS IN VERY OLD PATIENTS ON VKA TREATMENT FOR VENOUS THROMBOEMBOLISM. RESULTS OF A PROSPECTIVE MULTICENTER STUDY Erin Mathiesen Hald, Caroline Lind, Ellisiv Bøgeberg Mathiesen, Tom Wilsgaard, Inger Njølstad, Sigrid Brækkan, John-Bjarne Hansen Daniela Poli, Emilia Antonucci, Sophie Testa, Benilde Cosmi, Gualtiero Palareti, Walter Ageno CO9: Microparticles (Auditorium Rhodes) Chair: David Varon and Anne Marie Fischer C0047 PHARMACOGENETIC TESTS COULD BE HELPFUL IN PREDICTING OF VKA MAINTENANCE DOSE IN ELDERLY PATIENTS AT TREATMENT INITIATION C0074 INCREASED NUMBER OF CIRCULATING AND PLATELET-DERIVED MICROPARTICLES IN HUMAN BLOOD ENHANCES THROMBOSIS ON ATHEROSCLEROTIC PLAQUES Mirjana Kovac, Ljiljana Rakicevic, Jelena Kusic-Tisma, Dragica Radojkovic Rosa Suades, Teresa Padró, Gemma Vilahur, Lina Badimon C0323 PREDICTION MODEL OF FLUINDIONE MAINTENANCE DOSE (A NON-COUMARIN VITAMIN K ANTAGONIST) IN THE ELDERLY INCLUDES BODYWEIGHT, AMIODARONE INTAKE, VKORC1, CYP4F2, ABCB1 GENOTYPES BUT NOT CYP2C9 GENOTYPE C0128 DECREASE OF MICROPARTICLES AND HEMOSTASIS IMPROVEMENT AFTER THE TREATMENT IN HEMOPHILIA A. COINCIDENCE OR CAUSATION? Jovan P Antovic, Fariborz Mobbarez, Danijela Mikovic, Aleksandra Antovic Moreau Caroline, Berndt Célia, Pautas Eric, Andro Marion, Mahe Isabelle, Lacut Karine, Le Gal Grégoire, Duverlie Charlotte, Lecorche Emmanuel, Gouin-Thibault Isabelle, Golmard Jean-Louis, Loriot Marie-Anne, Siguret Virginie C0082 CIRCULATING LEUKOCYTE- AND ENDOTHELIAL-DERIVED MICROPARTICLES SUPPORT A FIBRINOLYTIC ACTIVITY. C0356 EVALUATION OF INRPLUS, A PORTABLE DEVICE IN THE MANAGEMENT OF FLUINDIONE, AN ORAL ANTICOAGULANT TREATMENT: A PROSPECTIVE CLUSTER RANDOMIZED CONTROLLED, OPEN TRIAL. Romaric Lacroix, Laurent Plawinski, Stéphane Robert, Loïc Doeuvre, Florence Sabatier, Sara Martinez de Lizarrondo, Anna Mezzapesa, Francine Anfosso, Aurelie S. Leroyer, Pascale Poullin, Noémie Jourde, Sébastien M. Njock, Denis Vivien, Chantal M. Boulanger, Eduardo Angles-Cano, Françoise Dignat-George Pernod Gilles, Imbert Patrick, Jacquet Jean-Philippe, Bailly Cécile, Laporte Silvy, Lièvre Michel C0078 DOSE MODIFYING EFFECT OF VKORC1 9041G>A AND 6009C>T GENE- POLIMORPHISMS IN ACENOCOUMAROL ANTICOAGULATED HUNGARIAN OUTPATIENTS C0431 MICROPARTICLE TF/ TFPI HEMOSTATIC BALANCE IN PHYSIOLOGICAL AND PATHOLOGICAL STATES Anat Aharon, Benjamin Brenner C0059 CIRCULATING LEVELS OF P-SELECTIN GLYCOPROTEIN LIGAND-1 (PSGL-1) POSITIVE MICROPARTICLES ARE INCREASED IN PATIENTS WITH UNPROVOKED VENOUS THROMBOEMBOLISM Réka Mózes, Orsolya Tóth, Hajna Losonczy, Marianna Dávid, Barbara Réger, Béla Melegh, Ágnes Nagy C0149 LONG-TERM TREATMENT OF VENOUS THROMBOEMBOLISM, WITH MODERATE-INTENSITY VITAMIN-K ANTAGONISTS (VKA) (INR RANGE BETWEEN 1.8 - 2.5), IMPROVE PATIENT COMFORT AND DECREASES TREATMENT COSTS, WITHOUT INCREASING ADVERSE EFFECTS: A MATCHED PAIRED STUDY 17:00-18:20 Plenary Session (Auditorium Athéna) Chair: Pier M. Mannucci 17:00-17:40 New insights into the contact activation system Thomas Renné CO8: Cardiac diseases (Auditorium Hermès) Chair: Grigoris Gerotziafas 17:40-18:20 Angiogenesis Augustin Hellmut Francesc J. Casals Solé C0316 EFFECTS OF HEMODYNAMIC FORCES ON TISSUE FACTOR RNA EXPRESSION IN HUMAN ENDOTHELIAL CELLS Bauer Sumpio Manjunath Goolyam Basavaraj, John-Bjarne Hansen GALA DINNER Tuesday October 9th 08:30-09:45 Scientific Symposia Antiphospholipid antibodies (Auditorium Athéna) Chairs: Sami Guermazi and Denis Gerard Wahl ISTH Guidelines Vittorio Pengo Anti beta2 glycoprotein antibodies: are they pathogen? Bas de Laat Antiphospholipid antibodies: evaluation of the thrombotic risk Katrien Devreese Drug-induced thrombosis (Auditorium Hermès) Chairs: Sabine Eichinger and Jacqueline Conard Oral contraception in women with mild thrombophilia: what we’ve learned recently? Ángeles Blanco Molina Adjuvant therapy for Breast cancer and thrombosis Mario Mandala Thrombotic risk and antipsychotics Francis Couturaud Antithrombotic agents and invasive procedures (Auditorium Rhodes) Chair: Charles Marc Samama Cardiologist point of view Jean-Philippe Collet Anesthesiologist point of view Pierre Albaladejo Hematologist point of view Thomas Lecompte 10:00-11:15 Oral Communications (CO10, CO11, CO12) CO10: Deep vein thrombosis (Auditorium Athéna) Chair: Nevine Kassim C0170 PROPHYLAXIS OF THROMBOTIC COMPLICATIONS IN A PREGNANT PATIENTS WITH PROSTHETIC HEART VALVES Alexander Makatsariya, Viktoriya Bitsadze, Dzhamilya Khizroeva, Svetlana Akinshina, Natalya Makatsariya C0208 PREVENTION OF VENOUS THROMBOEMBOLISM IN ACUTELY ILL MEDICAL PATIENTS WITH RENAL IMPAIRMENT: THE FONDAIR STUDY Walter Ageno, Nicoletta Riva, Patrizia Noris, Marcello Di Nisio, Micaela La Regina, Dimitriy Arioli, Luigi Ria, Valter Monzani, Stefano Cuppini, Enrico Lupia, Matteo Giorgi Pierfranceschi, Francesco Dentali C0302 PROGNOSTIC CLINICAL PREDICTION RULES TO IDENTIFY LOW-RISK PULMONARY EMBOLISM: A SYSTEMATIC REVIEW AND META-ANALYSIS Alessandro Squizzato, Marco P Donadini, Luca Galli, Francesco Dentali, Drahomir Aujesky, Walter Ageno C0322 FACTORS ASSOCIATED WITH THERAPEUTIC STRATEGIES IN PATIENTS WITH SPLANCHNIC VEIN THROMBOSIS: RESULTS OF AN INTERNATIONAL REGISTRY Nicoletta Riva, Walter Ageno, Sam Schulman, Soo-Mee Bang, Maria Teresa Sartori, Elvira Grandone, Jan Beyer, Giovanni Barillari, Dario Di Minno, Rita Duce, Alessandra Malato, Rita Santoro, Daniela Poli, Peter Verhamme, Ida Martinelli, Pieter Kamphuisen, Adriano Alatri, Doyeun Oh, Elbio D’Amico, Francesco Dentali C0383 DIAGNOSTIC ACCURACY OF LUNG ULTRASOUND FOR PULMONARY EMBOLISM: A META-ANALYSIS Alessandro Squizzato, Elena Rancan, Francesco Dentali, Walter Ageno CO11: Vascular biology (Auditorium Hermès) Chairs: Amparo Estellés and Essam Aboelnazar Chairmen: Amparo Estelles and Klaus T. Preissner C0077 TISSUE FACTOR AND METALLOPROTEINASES EXPRESSION IN TWO CELL THERAPY PRODUCTS: RELEVANCE FOR THE THROMBOGENICITY IN VASCULAR CELL THERAPY. Tournois Claire, Cuccuini Wendy, Poitevin Gael, Pignon Bernard, Sevestre Marie Antoinette, Nguyen Philippe C0081 TISSUE FACTOR EXPRESSION AND MICRORNAS –17-5P AND –20A IN ENDOMETRIAL CELL CULTURES FROM WOMEN WITH ENDOMETRIOSIS: ITS MODULATION BY PERITONEAL FLUID Aitana Braza-Boils, Juan Gilabert-Estellés, Luis Andrés Ramón, Juan Gilabert Aguilar, Melitina Chirivella Casanova, Francisco España Furió, Amparo Estellés Cortés C0080 INFLUENCE OF PERITONEAL FLUID ON MICRORNAS RELATED TO ANGIOGENESIS AND ANGIOGENIC AND FIBRINOLYTIC FACTORS EXPRESSION IN STROMAL CELL CULTURES OF EUTOPIC ENDOMETRIA AND OVARIAN ENDOMETRIOMAS FROM WOMEN WITH ENDOMETRIOSIS Aitana Braza-Boils, Juan Gilabert-Estellés, Luis Andrés Ramón, Juan Gilabert Aguilar, Melitina Chirivella Casanova, Francisco España Furió, Amparo Estellés Cortés C0412 SOLUBLE CD146: A NEW ANGIOGENIC FACTOR INVOLVED IN PHYSIOPATHOLOGY Karim Harhouri, Nathalie Bardin, Françoise Dignat-George, Marcel Blot-Chabaud CO125 IN VITRO EFFECT OF THE DIRECT XA INHIBITOR, APIXABAN, ON GLOBAL COAGULATION LABORATORY TESTS AND COAGULATION FACTOR ASSAYS: COMPARISON OF 10 APTT AND 10 PT REAGENTS, AND TWO COAGULOMETERS. A “GROUPE D’ETUDE SUR L’HÉMOSTASE ET LA THROMBOSE” STUDY. Gouin-Thibault Isabelle, Flaujac Claire, Horellou MarieHélène, Lacarrière Nicole, Lecompte Thomas CO12: Protein C (Auditorium Rhodes) Chairs: Charles T. Esmon and Ismaïl Elalamy C0034 A SIMPLIFIED ASSAY FOR QUANTIFICATION OF CIRCULATING ACTIVATED PROTEIN C LEVELS Elena Bonet, Laura Martos, Silvia Navarro, Pilar Medina, Amparo Estelles, Francisco España C0068 HAPLOTYPES OF THE ENDOTHELIAL PROTEIN C RECEPTOR GENE AND CIRCULATING PROTEIN C LEVELS Laura Martos, Elena Bonet, Pilar Medina, Silvia Navarro, Esther Zorio, Joaquín Rueda, José A. Aznar, Miguel A. Arnau, Ana M. Osa, Amparo Estellés, Rogier M. Bertina, Francisco España C0069 ASSOCIATION OF HAPLOTYPES (H) 1 AND 3 OF THE ENDOTHELIAL PROTEIN C RECEPTOR GENE (PROCR) WITH VENOUS THROMBOEMBOLISM Elena Bonet, Silvia Navarro, Pilar Medina, Laura Martos, Fernando Ferrando, Amparo Vayá, Yolanda Mira, José A. Aznar, Amparo Estellés, Rogier M. Bertina, Francisco España C0235 IDENTIFICATION OF MUTATIONS IN THE PROTEIN C GENE IN A PANEL OF 65 SPANISH FAMILIES WITH PROTEIN C DEFICIENCY Laura Martos, Silvia Navarro, Pilar Medina, Elena Bonet, María F. López-Fernández, Vanessa Roldán, Dolors Tássies, Pascual Marco, Ignacio Alberca, Javier Corral, Yolanda Mira, Ramón Lecumberri, Gemma Iruin, Francisco Velasco, Juan C. Reverter, Fernando Ferrando, María J. Costa-Pinto, Amparo Vayá, Vicente Vicente, Ana G. Mauricio, José R. González-Porras, Juan Monteagudo, Teresa MartínezMarini, María L. Blanco, José A. Aznar, Amparo Estellés, Francisco España C0076 THE ENDOTHELIAL PROTEIN C RECEPTOR IS ESSENTIAL FOR PROTEIN C ACTIVATION IN VIVO C0094 HIGH INCIDENCE OF COMPOUND HETEROZYGOSITY IN ANTITHROMBIN DEFICIENCY: DIAGNOSTIC AND PROGNOSTIC RELEVANCE. Elena Bonet, Pilar Medina, Silvia Navarro, Laura Martos, Amparo Estellés, Rogier M. Bertina, Francisco España 11:15-11:45 Sonia Aguila, Irene Martínez-Martínez, Miriam Collado, Pilar Llamas, Antonia Miñano, Ana Isabel Antón, María Eugenia de la Morena-Barrio, Vicente Vicente, Javier Corral Coffee Break 11:45-13:00 Plenary Session (Auditorium Athéna) Chair: Françoise Dignat-George 11:45-12:20 What did we learn from new oral anticoagulant treatment? Charles T. Esmon 12:20-13:00 Endothelial progenitor cells and therapeutic angiogenesis Jean-Sébastien Silvestre 13:00-14:00 Posters session (PS3) (Foyer) 14:00-15:30 Oral Communications (CO13, CO14, CO15) C0176 INFLUENCE OF COMMON THROMBOPHILIA POLYMORPHISMS ON THE THROMBOSIS RISK IN PATIENTS WITH JAK2-V617F-POSITIVE MYELOPROLIFERATIVE NEOPLASMS Vangelis Giamouris, Mariana Befani, Emanouil Papadakis, Eudokia Mandala, Nikolaos Papadoulis, Spyros Karamagiolis, Vassiliki Gastari, Eugenia Verrou, Eirini Katodritou, Stelios Lafioniatis, Zafiris Kartasis, Konstantinos Magiannis, Paulina Marinaki, Konstantina Tsioni, Anna Kioumi, Anastasios E. Germenis, Matthaios Speletas C0372 ENHANCED THROMBIN GENERATION IN WOMEN WITH HISTORY OF ORAL CONTRACEPTION RELATED VENOUS THROMBOSIS CO13: Women’s Health (Auditorium Athéna) Chair: Jacqueline Conard Saša Anžej Doma, Maja Vučnik, Mojca Božič Mijovski, Polona Peternel, Mojca Stegnar C0284 DOES A TIGHT FIBRIN CLOT IN PREMENOPAUSAL WOMEN WITH TYPE 1 DIABETES EXPLAIN THE LACK OF GENDER DIFFERENCE IN CARDIOVASCULAR DISEASE? C0430 IS THE PRESENCE OF THE MUTATION OF FXIII A KEY OF EPIGENETIC IMPACT IN THE EXPRESSION OF THROMBOPHILIC PREDISPOSITION? Makris Pantelis, Pagourelias E., Makris MP., Papadopoulou AA., Giannoglou G. Aleksandra Antovic, Nils Håkan Wallèn, Graciela Elgue, Koteiba Majeed, Peter Henriksson, Anna Ågren, Ulf Adamson, Per-Eric Lins, Gun Jörneskog CO15: Antiplatelets agents (Auditorium Rhodes) Chairs: Thomas Lecompte and Juana Valles C0298 DIFFERENTIAL RISK FACTORS FOR PREGNANCY RELATED DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM - RESULTS FROM A POPULATIONBASED CASE-CONTROL STUDY C0231 PATIENTS PRESENTING WITH AN ACUTE CORONARY SYNDROME WHILE ON CHRONIC ASPIRIN TREATMENT: DO THEY REQUIRE A LOADING DOSE OF ASPIRIN ? Astrid Bergrem, Anders E.A. Dahm, Anne Flem Jacobsen, Leiv Sandvik, Per Morten Sandset Isabel Madrid, Antonio Moscardo, Juana Valles, Miguel Ruano, Juan Bonastre, Ana Maria Latorre, Maria Teresa Santos C0355 PREGNANCY RELATED THROMBOSIS RISK IN PATIENTS WITH PROTEIN C DEFICIENCY Rugeri Lucia, Khouatra Linda, Arnuti Brigitte, Trzeciak Marie-Christine, Dargaud Yesim C0258 IMPORTANCE OF THE EFFECT OF ASPIRIN IN PATIENTS WITH ACUTE CORONARY SYNDROME WHO HAVE AN ADEQUATE ANTIPLATELET EFFECT OF CLOPIDOGREL. C0380 LONG-TERM IMPACT OF VENOUS THROMBOSIS ON QUALITY OF LIFE, GENERAL HEALTH AND FUNCTIONING: A CROSS-SECTIONAL, CASE-CONTROL STUDY Isabel Madrid, Antonio Moscardo, Juana Valles, , Juan Bonastre, Miguel Ruano, Ana Latorre, Maria Teresa Santos Hilde Skuterud Wik, Anne Flem Jacobsen, Leiv Sandvik, Per Morten Sandset C0338 CORRELATION BETWEEN PLATELET FUNCTIONAL PARAMETERS MEASURED BY IMPENDANCE AGGREGOMETRY AND BLOOD COAGULATION MARKERS WITH OCCURRENCE OF MAYOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION TREATED WITH PRIMARY PERCUTANEOUS C0385 MORTALITY AFTER PREGNANCY-RELATED VENOUS THROMBOSIS Hilde Skuterud Wik, Anne Flem Jacobsen, Leiv Sandvik, Per Morten Sandset C0167 PREGNANCY AND LABOR IN PATIENTS WITH HISTORY OF ISCHEMIC STROKE. Tina Kocica, Nebojsa Antonijevic, Nebojsa Savic, Lazar Davidovic Alexander Makatsariya, Viktoriya Bitsadze, Dzhamilya Khizroeva, Svetlana Akinshina C0278COMPARATIVE EFFECTIVENESS OF DIFFERENT DOSES ANTIPLATELET THERAPY AND FORMS ACETYLSALICYLIC ACID IN PATIENTS WITH STABLE ANGINA CO14: Thrombophilia (Auditorium Hermès) Chairs: Turgut Ulutin and Ulrich Abildgaard Oksana Demyanenko, Valeriy Vishnevskiy C0229 REGULATORY REGIONS OF SERPINC1 GENE: IDENTIFICATION OF THE FIRST MUTATION ASSOCIATED WITH ANTITHROMBIN DEFICIENCY. C0279 HYPERCHOLESTEROLEMIA - A RESISTANCE FACTOR IN ANTIPLATELET THERAPY María Eugenia de la Morena-Barrio, Ana Isabel Antón, Irene Martínez-Martínez, Jose Padilla, Antonia Miñano, Jose Navarro-Fernández, Sonia Águila, María Fernanda López, Jordi Fontcuberta, Vicente Vicente, Javier Corral C0075 TYPE II ANTITHROMBIN DEFICIENCY CAUSED BY A LARGE IN-FRAME INSERTION. STRUCTURAL, FUNCTIONAL AND PATHOLOGICAL RELEVANCE. Irene Martínez-Martínez, Daniel J.D. Johnson, Masayuki Yamasaki, José Navarro-Fernández, Adriana Ordóñez, Vicente Vicente, James A. Huntington, Javier Corral Valeriy Vishnevskiy, Oksana Demyanenko 16:00 End of the Congress Poster Session 17:50-18:30 Posters Session (PS1) (Foyer) P0018 New mutation SS => 125 in DVT Jean-François Schved P0024 Nicotinic acid/laropiprant addition to chronic lipid apheresis in very high-risk patients with acute coronary syndromes. Gabriele Cioni, Rossella Marcucci, Lucia Mannini, Sandra Fedi, Stefano Bucci, Alfredo Sabato, Rosanna Abbate, Giovanna D’Alessandri P0028 Efficacy and safety Koagil-VII (JSC “Pharmstandard”) administration after cardiac surgery in patients with high bleeding risk Galina V. Lobacheva, Mikhail M. Rybka, Natalia N. Samsonova, Elena F. Kozar P0050 Eplerenone, a new selective mineralocorticoid receptor antagonist, inhibits platelet adhesion and attenuates endothelial damage in arterial thrombosis model in diabetic rats. Ewa Chabielska, Urszula Bycul, Agnieszka Zakrzeska, Piotr Szoka, Wioleta Kisiel, Irena Kasacka P0064 Adrenal gland-dependent process of arterial thrombus formation in diabetic rats Piotr Szoka, Agnieszka Zakrzeska, Urszula Bycul, Wioleta Kisiel, Irena Kasacka, Ewa Chabielska P0065 WHITE BLOOD CELL COUNT MEASURED PRIOR TO CANCER DEVELOPMENT IS ASSOCIATED WITH FUTURE RISK OF VENOUS THROMBOEMBOLISM IN CANCER PATIENTS – THE TROMSØ STUDY Hilde Jensvoll, Kristine Blix, Sigrid Brækkan, John-Bjarne Hansen P0084 The effect of CME educational programs on VTE morality & morbidity in King Fahad Hospital – Jeddah –KSA Essam AboElNazar, Fahd Alhameed P0088 DIFFERENTIAL ASSOCIATIONS BETWEEN EDUCATIONAL LEVEL AND FUTURE RISK OF VENOUS THROMBOEMBOSLISM AND MYOCARDIAL INFARCTION. THE TROMSØ STUDY. Kristin F. Enga, Knut Gjelland, Sigrid K. Brækkan, John-Bjarne Hansen P0092 Predictive factors for venous recanalisation after first idiopathic venous thrombosis Tjasa Vizintin-Cuderman, Monika Stalc, Alenka Mavri P0093 HEMATOCRIT MEASURED PRIOR TO CANCER DEVELOPMENT IS NOT ASSOCIATED WITH FUTURE RISK OF VENOUS THROMBOEMBOLISM IN CANCER PATIENTS – THE TROMSØ STUDY Hilde Jensvoll, Kristine Blix, Sigrid Brækkan, John-Bjarne Hansen P0103 MEDITERRANEAN PARADOX: DOES IT EXIST IN VENOUS THROMBOEMBOLIC DISEASE Juan Francisco Sanchez Muñoz-Torrero, Alicia Lorenzo Hernández, Javier Trujillo P0104 EVOLUTION OF VENOUS THROMBOEMBOLIC DISEASE IN PATIENTS WITH DIABETES: RISK OR PROTECTOR FACTOR? Alicia Lorenzo Hernández, Maria Del Carmen Fernández Capitán, Sarah Caro Bragado, Maria De Los Angeles Rodriguez Dávila, Mikel Rico Briñas, Maria Fernández Velilla, Maria Cuesta, Maria Isabel Torres Sánchez P0105 DIABETIC PATIENTS AND VENOUS THROMBOEMBOLIC DISEASE. IS THERE ANY DIFFERENCE? María Del Carmen Fernández Capitán, Alicia Lorenzo Hernández, Sarah Caro Bragado, María Angeles Rodriguez Dávila, Mikel Rico Briñas, Marina Triguero Genao, María Fernández Velilla, María Osabel Torres, María Isabel Torres P0106 DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM: SAME DISEASE IN DIABETIC PATIENTS? Alicia Lorenzo Hernández, María Del Carmen Fernández Capitán, Juan Francisco Sánchez Muñoz-Torrero, Mikel Rico Briñas, Marina Triguero Genao, Georgina Salgueiro, María Fernández Velilla, María Isabel Torres Sánchez, Maria Angeles Rodriguez Davila P0110 SERUM LEVELS OF VITAMIN D IS NOT ASSOCIATED WITH FUTURE RISK OF VENOUS THROMBOEMBOLISM – THE TROMSØ STUDY Ellen Brodin, Gunhild Lerstad, Guri Grimnes, Sigrid K Brækkan, Johan Svartberg, Rolf Jorde, John-Bjarne Hansen P0135 In vitro and in silico study of the effect of crocin and safranal on human plasma coagulation Maria Ditsa, George Geromihalos, Eleftheria Tragoulia, Dimitra Markala, Chrisa Meleti, Zaxarias Sinakos P0144 The comparison of two different antithrombotic regimens in patients with atrial fibrillation for the prevention of ishaemic stroke Sladjana Novaković-Anučin, Sanja Gnip, Višnja Čanak, Pavica Radović, Milena Šćekic, Jelena Kovačev, Gorana Mitić P0145 Haemostatic System Changes in Orthotopic Liver Transplantation - single center experience Sladjana Novaković-Anučin, Sanja Gnip, Višnja Čanak, Djurdjina Jurišić, Pavica Radović, Svetlana Erdeljan, Zoran Milošević, Gorana Mitić P0150 The features of antiplatelet therapy in inflammation Liudmila Buryachkovskaya, Alexander Sumarokov, Irina Uchitel P0151 The role of p-selectin in deep venous thrombosis: a metaanalysis Constantine Antonopoulos, Triantafillos Giannakopoulos, Aristeidis Kallinis, Ioannis Vasilopoulos, Ilias Dalainas, John Kakisis, Christos Liapis P0153 Evaluation of atrial fibrillation population in Apulia region for the cost/effectiveness analysis for the use of old and new oral anticoagulants: cooperation of hematologist, cardiologist and internist Nicola Ciavarella, Paolo Colonna, Ennio Michelotto, Vito Lepore, Fabio Robusto, Elvira Grandone, Luigi Ria, Giacomo Lucarelli, Salvatore Bradamante, Michele Virgilio, Gianfranco Antonelli, Pasquale Caldarola, Carlo D’Agostino, Stefano Favale, Giovanni Tognoni P0159 β1 blockers, warfarin and rhythm conversion in atrial fibrillation Ruzan Durgaryan P0163 Role of A3 haplotype of EPCR in the development of deep vein thrombosis in Asian Indian. Amit Sharma, Arijit Biswas, Ravi ranjan, Mohd. Suhail Akhter, Ravi kumar, Kamal Kishor, Renu Saxena P0168 The APCR ratio is differently influenced by warfarin therapy when different assays are used. Petr Kessler, Hynek Poul, Arnost Komarek, Maria Kusnierova, Michaela Harudova P0169 Cave thrombosis in Behçet’s disease: A report of 29 cases. Ben Ghorbel Imed, Belfeki Nabil, Said Fatma, Ben Salem Thouraya, Lamloum Mounir, Braham Amel, Khanfir Monia, Hamzaoui Amira, Houman Habib P0172 Unusual complication in Wegener’s granulomatosis: deep venous thrombosis. About four cases. Ben Ghorbel Imed, Belfeki Nabil, Braham Amel, Lamloum Mounir, Ben Salem Thouraya, Khanfir Monia, Hamzaoui Amira, Houman Habib P0178 CYP2C9 and VKORC1 gene polymorphisms in the healthy Russian and Buryat respondents in Transbaikalia Olga Stepanova, Marine Avetisyan, Yuri Vitkovsky P0179 DEEP VEIN THROMBOSIS OF UPPER EXTREMITIES(UEDVT): A TERTIARY CENTER’S EXPERIENCE Anastasia Banti, Emmanouil Papadakis, Vassilios Papadopoulos, Konstantinos Loukidis, Dionysia Theocharidou, Smaragda Efraimidou, Anna Karagianni, Vaia Papageorgiou, Vassiliki Pissanidou, Parthena Kapali, Anna Kioumi P0181 The association of functional polymorphisms of IL-6 gene promoter With ischemic stroke. Mohd. Suhail Akhter, Arijit Biswas, Ravi Ranjan, Amit Sharma, kamal kishor, Renu Saxena P0183 Atypical Hemolytic- Uremic syndrome by deficit in MCP diagnosed at a teenager Hedouas Meriem, Khedri Nassima P0185 Can overall haemostasis potential (OHP) discriminate between patients who will suffer early restenosis after femoropopliteal percutaneous transluminal angioplasty (PTA) from those who will not? Maja Vučnik, Vinko Boc, Aleš Blinc, Matjaž Vrtovec, Rok Perme, Barbara Krevel, Matija Kozak, Petra Malovrh, Barbara Eržen, Mojca Božič-Mijovski, Mojca Stegnar P0186 HOMOCYSTEINE AND Lp(a) IN PATIENTS WITH ISCHAEMIC CEREBROVASCULAR ACCIDENTS Aikaterini Hasiou, Michail Hasios, Paraskevi Karapavlidou, Anastasia Dimitrouli, Ioanna Passalidou P0206 EFFECTIVENESS AND SAFETY OF ARGATROBAN IN THE ACUTE TREATMENT OF DEEP VEIN THROMBOSIS IN PATIENT WITH ALLERGY TO HEPARIN UNDERGOING RENAL REPLACEMENT THERAPY: A CASE REPORT Matteo Giorgi-Pierfranceschi, Roberto Scarpioni, Sergio Ballocchi, Vittorio Albertazzi, Stefania D’Amore, Sara De Amicis, Marco Ricardi, Piergiorgio Poisetti P0225 DIGITAL TV AND MOBILE DEVICES TO INCREASE THE COMPLIANCE/ PERSISTENCE TO MEDICINES IN CHRONIC SUBJECTS ON ORAL ANTICOAGULANT DRUGS: THE PILOT STUDY Giovanni Dirienzo, Nicola Ciavarella, Lino Renna, Nicola Pansini, Michele Virgilio P0232 Curcumin attenuates inflammatory and thrombotic events induced by repeated pulmonary exposure to diesel exhaust particles in mice Abderrahim Nemmar, Deepa Subramaniyan, Badreldin Ali P0239 Which are the most evidence-based and cost-effective strategies for treating patients with heart failure? Jennifer Creed P0287 Assessment of endothelial function by peripheral arterial tonometry in patients with previous acute coronary syndrome identifies systemic atherosclerosis independently of traditional risk factors. Gabriele Cioni, Rossella Marcucci, Francesca Cesari, Serafina Valente, Cristina Giglioli, Rosanna Abbate, Maria Boddi P0292 LIPID LEVELS AND RISK OF VENOUS THROMBOSIS Aránzazu García Raso, Raquel Mata, Rosa Vidal, Sol Sánchez, Pilar Llamas P0294 DEEP VENOUS THROMBOSIS IN PATIENTS WITH No O- GROUP Aránzazu García Raso, Raquel Mata, Elham Askari, Claudia Gorcea, Pilar Llamas P0305 DEEP VEIN THROMBOSIS AND MALFORMATIONS OF INFERIOR VENA CAVA Ruth Calderón Hernáiz, Justo Ruiz Ruiz, Olga Mateo Rodriguez, Diego Orlando Rejas Velasquez, Elena Madroñal Cerezo, Rosa María Martín Díaz, Alicia Castro Gordon, María Fernández López, Jesús Canora Lebrato, Antonio Zapatero Gaviria P0307 Baseline characteristics and management of patients with splanchnic vein thrombosis: results of an International Registry Walter Ageno, Nicoletta Riva, Sam Schulman, Soo-Mee Bang, Maria Teresa Sartori, Elvira Grandone, Jan Beyer, Giovanni Barillari, Dario Di Minno, Rita Duce, Alessandra Malato, Rita Santoro, Daniela Poli, Peter Verhamme, Ida Martinelli, Pieter Kamphuisen, Adriano Alatri, Doyeun Oh, Elbio D’Amico P0309 VENA CAVA THROMBOSIS IN BEHCET DISEASE Bellakhal Syrine, Hamzaoui Amira, Saïd Fatma, Ben Salem Thouraya, Smiti-Khanfir Monia, Braham Amel, Ben Ghorbel Imed, Lamloum Mounir, Houman Mohamed-Habib P0318 NEUROLEPTIC DRUGS AND VENOUS THROMBOEMBOLIC DISEASE María Jesús Jaras Hernández, Jose Francisco Pascual Pareja, Alicia Lorenzo Hernández, Mar Matin Pozo, José.M Luque. Pinilla, Javier Gutierrez Guisado, Olga Madridano Cobo, M.Angeles Rodriguez Dávila, Carmen Fernández Capitán P0320 Oral anticoagulation in atrial fibrillation, the patients and physicians experiences of the consultation; a qualitative study. Christian Borg Xuereb, Rachel L. Shaw, Gregory Y.H. Lip, Deirdre A. Lane P0325 A 40 years survey of pulmonary embolism documented at autopsy in a tertiary care hospital from Cordoba, Argentina Aldo Hugo Tabares, Romina Montivero, Rosio Baena Terán, Carina Seculini, Andres Arancibia, Luciana Guanchiale, Ana Diller, Juan García P0335 Vitamin K antagonists treatment and endogenous thrombin potential in patients with venous thromboembolism. Veronika Shmeleva, Yriy Namestnikov, Olesya Matvienko, Vitaly Soldatenkov P0336 Venous thromboembolism (VTE) at rare sites in neonates and children Pergantou Helen, Avgeri Maria, Komitopoulou Anna, Xafaki Panagiota, Kapsimali Zoey, Karelioti Helen, Platokouki Helen P0359 Characteristics of Deep venous thrombosis in Tunisian Behçet’s disease patients Bellakhal Syrine, Saïd Fatma, Ben Salem Thouraya, Hamzaoui Amira, Braham-Sfaxi Amel, Smiti-Khanfir Monia, Ben Ghorbel Imed, Lamloum Mounir, Houman Mohamed-Habib P0368 A feverish lumbago at a patient with a Behçet’s disease in remission : think of the thrombosis of the renal vein Mounir Lamloum, Mounir Lamloum, Imène Rachdi, Imed Ben Ghorbel, Thouraya Ben Salem, Amira Hamzaoui, Monia Khanfir, Amel Braham, Mohamed Habib Houman P0370 Plasma levels of soluble CD36, platelet activation, inflammation and oxidative stress are increased in type 2 diabetic patients Simona Sestili, Francesca Santilli, Bente Halvorsen, Aase Handberg, Rossella Liani, Natale Vazzana, Gloria Formoso, Pål Aukrust, Giovanni Davì P0371 Venous thrombosis in amebic colitis Mounir Lamloum, Imène Rachdi, Imed Ben Ghorbel, Amira Hamzaoui, Thouraya Ben Salem, Monia Khanfir, Amel Braham, Mohamed Habib Houman P0373 Venous thrombosis revealing a Crohn’s disease Mounir Lamloum, Imène Rachdi, Imed Ben Ghorbel, Amira Hamzaoui, Thouraya Ben Salem, Monia khanfir, Amel Braham, Mohamed Habib Houman P0376 Venous thrombosis revealing a multiple myeloma Mounir Lamloum, Imène Rachdi, Imed Ben Ghorbel, Amira Hamzaoui, Thouraya Ben Salem, Monia khanfir, Amel Braham, Mohamed Habib Houman P0389 Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost. Natale Vazzana, Gianfranco Lessiani, Chiara Cuccurullo, Dario Di Michele, Giuseppe Laurora, Giuseppe Sgrò, Paolo Di Ruscio, Emilio Simeone, Pierangelo Di Iorio, Stefano Lattanzio, Rossella Liani, Giovanni Davì P0392 Cancer-associated thrombosis; a study of 806 cases of deep venous thrombosis Smiti Khanfir Monia, Bellakhal Syrine, Hamzaoui Amira, Ben Salem Thouraya, Braham Amel, Ben Ghorbel Imed, Lamloum Mounir, Houman Mohamed Habib P0393 Risk factors and prevalence of venous thromboembolism in internal medicine: A retrospective study of 806 patients Bellakhal Syrine, Smiti Khanfir Monia, Hamzaoui Amira, Said Fatma, Ben Salem Thouraya, Braham Amel, Lamloum Mounir, Ben Ghorbel Imed, Houman Mohamed Habib P0395 Hyperhomocysteinemia, thrombosis and pernicious anemia. Four new cases. Tazi Mezalek Zoubida, Ammouri Wafaa, Harmouche Hicham, Maamar Mouna, Adnaoui Mohamed, Aouni Mohamed P0396 Venous thrombosis revealing celiac disease. Three cases. Tazi Mezalek Zoubida, Benecer Alaoui Habiba, Harmouche Hicham, Bachir Houda, Maamar Mouna, Adnaoui Mohamed, Aouni Mohamed P0397 Thromboembolitic events in patients with systemic Vasculitis Bellakhal Syrine, Hamzaoui Amira, Hajji Raouf, Smiti-Khanfir Monia, Ben Salem Thouraya, Braham-Sfaxi Amel, Ben Ghorbel Imed, Lamloum Mounir, Houman Mohamed-Habib P0408 Case report: Oral contraceptives, thrombophilias and deep vein thrombosis in young women after tonsillectomy Tiha Vucemilo, Marija Skoko, Deana Sturm P0409 Prevalence of atrial fibrillation in patients presenting with stroke Uchenna Ozo, Khalil Peroo, Gemma Fitzpatrick, Khalil Kawafi P0418 Use of thrombopoietin mimetics in Acute ITP Ashwini Arumugaswamy, Simon He, Hang Quach, Andrew Grigg P0426 ENDOTHELIAL PROTEIN C RECEPTOR GENE POLYMORPHISMS AND RISK OF VENOUS THROMBOSIS IN YOUNG PATIENTS Georgia Anastasiou, Argyri Gialeraki, Eufrossyni Merkouri, Loukianos Rallidis, Anthi Travlou P0428 Visualization of the platelet function Makris Pantelis, Makris Michael 12:45-13:45 Posters session (PS2) (Foyer) P0079 TF/TFPI in chronic myeloproliferative disorders. Danuta Rosc, Katarzyna Stankowska, Joanna Boinska, Grazyna Gadomska, Ewa Zekanowska, Wojciech Swistek P0095 Circulating endothelial cells and microparticles as prognostic markers in advanced Non-Small-Cell Lung Cancer Tania Fleitas, Vicenta Martínez-Sales, Virtudes Vila, Edelmiro Reganon, David Mesado, María Martín, José Gómez-Codina, Joaquín Montalar, Gaspar Reynés P0097 Microparticles and markers of coagulation, inflammation and angiogenesis in patients with glioblastoma before and after treatment with temozolomide and radiation therapy: Prognostic value Virtudes Vila, Gaspar Reynés, Tania Fleitas, María Martín, Edelmiro Reganon, Vicenta Martínez-Sales P0098 High levels of microparticles and markers of coagulation and inflammation distinguish decompensated heart failure vs to stable phase. Virtudes Vila, Ignacio Sánchez-Lázaro, Luis Almenar, Vicenta Martínez-Sales P0099 KINETICS AND MECHANISM OF INHIBITION BY ANGIOSTATIN OF PLASMINOGEN ACTIVATION UNDER THE ACTION OF UROKINASE AND TISSUE PLASMINOGEN ACTIVATOR Lilia Mukhametova, Roza Aisina, Karina Gershkovich, Dmitrii Gulin P0100 THE CONTRIBUTION OF FIBRINOLYSIS IMPAIRMENT TO THE DEVELOPMENT ON THROMBOSIS IN ANTIPHOSPHOLIPID SYNDROME (APS) Roza Aisina, Lilia Mukhametova, Tatiana Reshetnyak, Ekaterina Ostryakova, N Seredavkina, N Patrusheva, Lev Patrushev, Dmitrii Gulin, Karina Gershkovich P0118 Diagnostic difficulties for the detection of lupus anticoagulant: experience of the hematology laboratory at Charles Nicolle Hospital of Tunis. Ben Said Mehdi, Kallel Hajer, Chaker Farah, Ellouze Rym, Guermazi Sami P0119 Therapeutic Approach to Venous Paraneoplastic Thromboembolism. Experience From a Single Center Irene García-Cadenas, Amparo Santamaria, Jordi Fontcuberta P0120 Thromboembolic Events in Oncological Patients: A Single Center Experience. Irene García-Cadenas, Amparo Santamaria, Jordi Fontcuberta P0124 Assessment of risk factors for venous thromboembolism in women with breast carcinoma Zeljko Kovac, Mirjana Kovac, Valentina Djordjevic, Zorica Tomasevic, Iva Pruner, Dragica Radojkovic P0132 INVESTIGATING ANTIPLATELET ACTIVITY OF RED AND WHITE WINE Eleftheria Tragoulia, Maria Ditsa, Chrisa Meleti, Katerina Mparmpouti, Dimitra Markala P0134 Internet based questionnaire for the analysis of preference of patients for anticoagulants Zolfaghari Shabnam, Marx Svetlana, Abou Ayash Nadja, Kremer Christophe, Hoeing Vera, Schirk katrin, Weiss Christel, Frölich Lutz, Harenberg Job P0137 XAMOS: a large non-interventional study in patients undergoing major hip or knee replacement surgery and receiving oral rivaroxaban or conventional regimens for thromboprophylaxis Sylvia Haas, Alexander GG Turpie, Waheed Jamal, André Schmidt, Michael Rud Lassen, Lorenzo Mantovani, Reinhold Kreutz P0138 UTILIZATION OF WAVEFORM ANALYSIS OF ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT)- CLINICAL AND PROGNOSTIC VALUE. Eleftheria Tragoulia, Maria Ditsa, Poly Kazila, Chrisa Meleti, Anastasia Mpanti, Efi Yannaki, Dimitra Markala P0141 Radiotherapy and platelets activation in patients with prostate cancer Ewa Zekanowska, Danuta Rystok-Grabska, Tomasz Wisniewski, Ewa Ziółkowska, Artur Słomka, Paulina Giemza-Kucharska, Danuta Rosc P0148 Platelets coxsackie adenovirus receptor (CAR) in normal and inflammatory cardiac pathology. Elena Gupalo, Liudmila Buryachkovskaya, Pyotr Chumachenko, Natalia Mironova P0161 Lymphocyte-platelet adhesion in patients with chronic brain ischemia, carried IL-10 (G-1082A), IL-10 (C-819T) polymorphisms Anna Knyazeva, Nataliya Strambovskaya, Yuri Vitkovsky P0162 Analysis of the use of fibrinogen to treat acquired coagulopathies in a Portuguese Hospital Jorge Martinez, Patricia Amantegui, João Ribeiro, Inês Eusébio, Rita Moras, Rita Oliveira, Olímpia Fonseca, Ana Ramalhinho P0164 Clinical case report: patient with severe postpartum hemorraghe treated with high doses of fibrinogen concentrate Jorge Martinez, Patricia Amantegui, João Ribeiro, Inês Eusébio, Rita Moras, Rita Oliveira, Olímpia Fonseca, Ana Ramalhinho P0165 Cerebral Venous Thrombosis and Paroxysmal Nocturnal Hemoglobinuria: A Series of 12 Cases Meppiel Elodie, Crassard Isabelle, Peffault De Latour Régis, Chabriat Hugues, Socie Gérard, Bousser MarieGermaine P0173 High levels of von Willebrand factor antigen and procoagulant factor VIII found in multiple myeloma patients are associated with activity status Juraj Sokol, Emília Flochová, Juraj Chudej, Radoslava Šimonová, Daniela Chudá, Peter Chudý, Ján Staško, Peter Kubisz P0177 The participation of gamma/delta and alfa/beta Tlymphocytes in coagregates forming with platelets Alexey Solpov, Petr Tereshkov, Yuri Vitkovsky P0184 THE ANALYSIS OF CELL IMAGE OF PLATELETS IN VENOUS BLOOD OF PATIENTS WITH IDEOPATHIC TROMBOCYTOPENIC PURPURA Irina S. Kastrikina, Gennady I. Kozinets, Valery M. Pogorelov, Lidiya G. Kovaleva, Elena I. Pustovaya, Marem I. Chanieva, Svetlana N. Bytchkova P0191 ACUTE MYOCARDIAL INFARCTION AND NATURAL COAGULATION INHIBITORS Michail Hasios, Aikaterini Hasiou, Paraskevi Karapavlidou, Ioanna Passalidou P0194 A NEW ORAL ANTICOAGULANT (DABIGATRAN ETEXILATE): AVAILABILITY OF LABORATORY MONITORING Vladimir Sukhanov, Olga Petrova P0197 Evaluation of bleeding symptoms in case of inherited FVII deficiency: about 9 cases Ben Lakhal Fatma, El Borgi Wijdene, Ben Salah Naouel, Zahra Kaouther, Meddeb Balkis, Hafsia Raouf, Gouider Emna P0200 Clinical and Biological features of Von Willebrand disease type 3: report of a Tunisian series. Ben Lakhal Fatma, El Borgi Wijdene, Ben Salah Naouel, Zahra Kaouther, Zorguan Moez, Meddeb Balkis, Hafsia Raouf, Gouider Emna P0204 Factor XIII deficiency: a family report Ben Lakhal Fatma, El Borgi Wijdene, Ben Salah Naouel, Zahra Kaouther, Zorguan Moez, Mahmoudi Hajer, Meddeb Balkis, Hafsia Raouf, Gouider Emna P0205 SEVERE THROMBOTIC EVENTS IN YOUNG PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME Florencia Sundberg, Graciela Pedreira P0215 The occurrence of thrombo-haemoragic events in patients with polycythaemia vera and essential thrombocythaemia in relationship to presentation of JAK2V617F mutation. Zuzana Jedinakova, Jan Stasko, Daniela Chuda, Juraj Marcinek, Tatiana Burjanivova, Juraj Sokol, Peter Kubisz P0219 Inherited factor XI deficiency: a report of 11 cases and review of literature Elborgi Wijdene, Ben Lakhal Fatma, Ben Salah Naouel, Zahra Kaouther, Zorguan Moez, Meddeb Balkis, Hafsia Raouf, Gouider Emna P0220 Incidence of hemophilia in the North of Tunisia Elborgi Wijdene, Ben Lakhal Fatma, Ben Salah Naouel, Zahra Kaouther, Zorguan Moez, Meddeb Balkis, Hafsia Raouf, Gouider Emna P0236 PRE-ANALYTICAL CONDITIONS OF CENTRIFUGATION AND FREEZING BUT NOT TEMPERATURE AFFECT MP LEVELS Virtudes Vila, Silvia Navarro, Verónica Sánchez-López, Remedios Otero, Vicenta Martínez-Sales P0248 MPTP-dependent and -independent mechanisms of platelet apoptosis: Effects of cyclosporin A Valery Leytin, Armen Gyulkhandanyan, Asuman Mutlu, Sergiy Mykhaylov, David Allen, John Freedman P0249 Elastase-mediated fibrinolysis in disseminated intravascular coagulation (DIC) associated with sepsis Takeshi Wada, Satoshi Gando, Yuichiro Yanagida, Shinji Uegaki, Nobuhiko Kubota, Mineji Hayakawa, Atsushi Sawamura, Subrina Jesmin P0257 Rituximab in Refractory Antiphospholipid Syndrome Abdul Kareem Almomen, Sri-Halimah Cana, Rana Hasanato, Abdullah Abujamea P0259 THROMBIN GENERATION AND CONVENTIONAL COAGULATION MARKERS IN PATIENTS WITH HYPERCOAGULABLE STATE DUE TO LOW PT AND/OR APTT Evmorfia Papakonstantinou, Efstathios Yfantis, Anneta Theofani, Amalia Skourbouti, Paraskevi Georgutsu, Panagiotis Safioleas, Christina Sereti, Christina Manti P0261 THROMBIN GENERATION PARAMETERS IN ACUTE MYOCARDIAL INFRACTION, MULTIPLE MYELOMA AND IN MYELOPROLIFERATIVE DISORDERS Evmorfia Papakonstantinou, Efstathios Yfantis, Anneta Theofani, Anthi Lakoumenta, Aikaterini Lavda, Christos Pegos, Konstantinos Safioleas, Christina Manti P0264 PROTEIN Z MUTATIONS IN PATIENTS WITH FETAL LOSSES: STRUCTURAL ANALYSIS Giovanni, Luca Tiscia, Rocco Caliandro, Giovanni Nico, Valerio De Stefano, Elena Rossi, Tommaso Za, Giovanni Favuzzi, Filomena Cappucci, Lucia Fischetti, Donatella Colaizzo, Francesco Giuliani, Elvira Grandone P0267 Genotype-Phenotype relationship in Italian subjects with congenital FXI deficiency Giovanni Favuzzi, Giovanni, Luca Tiscia, Elena Chinni, Donatella Colaizzo, Valeria Bafunno, Gennaro Vecchione, Maurizio Margaglione, Elvira Grandone P0271 Platelets GPIBA and ITG A2 polymorphisms in the healthy Russian and Buryat respondents in Transbaikalia Marine Avetisyan, Olga Stepanova, Yuri Vitkovsky P0273 CENTRAL VENOUS CATHETER-RELATED THROMBOSIS IN PATIENTS WITH ACUTE LEUKEMIA Irena Djunic, Marijana Virijevic, Aleksandra Novkovic, Nada Suvajdzic-Vukovic, Ivo Elezovic, Predrag Miljic, Ana Vidovic, Natasa Coloovic, Dragica Tomin P0274 Smoking and other risk factoris in patients with acute myocardial infarction in southern Croatia Duska Glavas, Katarina Novak P0277 EXPERIENCE IN THE USE OF INTRAVENOUS IMMUNOGLOBULIN IN PREGNANT WOMEN WITH RECURRENT MISCARRIAGES AND ANTIPHOSPHOLIPID SYNDROME Dina Eremeeva, Marina Zaynulina P0280 Correlation beetween AnnexinV-FITC and Annexin V-V450 Positive Microparticles in two high sensitivity cytometers Verónica Sánchez-López, Virtudes Vila, Vicenta MartinezSalas, Emilia Martín-Rodriguez, Ana Montes-Worboys, Elena Arellano, Teresa Elias, Remedios Otero P0299 Thrombosis in newborns and neonates. Unsolved problems. Eugene Roitman, Alexandr Rumyantsev, Andrey Momot, Nicolay Volodin, Maria Shnader, Maria Shnader P0300 Measurement of rivaroxaban in urine by a point of care method Job Harenberg, Astrid Schulze, Christina Giese, Sandra Krämer, Shanshan Du, Misael Schleger, Roland Krämer P0301 Bleeding in four patients with excessive response to dabigatran: implications for emergency surgery and resuscitation. Agnès Lillo-Le Louët, Martine Wolf, Michel-Meyer Samama P0306 ACCURACY OF EMERGENCY PHYSICIAN–PERFORMED ULTRASONOGRAPHY IN THE DIAGNOSIS OF DEEP VEIN THROMBOSIS: a systematic review and a meta-analysis of the literature Fulvio Pomero, Francesco Dentali, Valentina Borretta, Matteo Bonzini, Remo Melchio, James D Douketis, Luigi M Fenoglio P0333 Management of Recurrent Abortion in Afibrinogenemia Woman Manijeh Lak P0337 Hyperhomocysteinemia as marker of higher thrombotic risk in patients with multiple myeloma. Veronika Shmeleva, Ecaterina Chait, Kudrat Abdulkadirov, Stanislav Bessmeltsev P0342 Exposure to hypoxic environment results in altered platelet proteome and reactivity Tarun Tyagi, Shadab Ahmad, Tathagat Chatterjee, Neha Gupta, Yasmin Ahmad, Shantanu Sengupta, M.Zahid Ashraf P0352 Evolution of thrombin generation (endogenous and exogenous pathway) in parallel with the anti-FVIII inhibitor level in a patient with acquired haemophilia, treated with MABTHERA. In vitro response to the addition of NOVOSEVEN. Mazoyer Elisabeth, Guinet Céline, Duflot Sandrine, Dhote Robin, Samama Michel Meyer P0358 UNDERSTANDING RECURRENT THROMBOSIS OF ANTIPHOSPHOLIPID SYNDROME. Harberth Fernandez, Nuria Bermejo Vega, Carolina Martin Aguilera, Fernando Carnicero, Fatima Ibañez Espacio, Maria Jose Arcos Carmona, Maria Elena Bañas, Carmen Cabrera Silva, Julio Prieto, Maria Jose Garcia Blanco, Marisa Martin Mateos, Juan M. Bergua Burgues P0377 Does FVL have an effect on longevity? Dilara Fatma Akın, Yonca Eğin, Nejat Akar P0384 Severe thrombocytopenia and metachronous dilated superficial veins and thrombosis: infection, autoimmune disorder or LGL cytopenia? Efthymia Rigatou, George Paterakis, Helen Platokouki, Kleoniki Roka, Georgia Avgerinou, Vassilios Papadakis, Sophia Polychronopoulou P0390 Fibrinolytic activity and d-dimer in Behçet’s disease Belfeki Nabil, Smiti Khanfir Monia, Hamzaoui Amira, Ben Salem Thouraya, Baccouche Hela, Mahjoub Sonia, Ben Romdhane Neila, Houman Mohamed Habib P0391 Disseminated intravascular coagulation in familial lymphohistiocytosis: a cytokin thunderstorm Daghor Abbaci Karima, Hakem Djennette, Berrah Abdelkrim P0398 Does buffy coat prepared for autologous stem cell transplantation in cancer patients has procoagulant properties? An in vitro study. Sidibe Fatoumata, Vassiliki Galea, Robert Françoise, Romain Marie Paule, Bernaudin Jean François, Lotz Jean Pierre, Selle Fréderique, Larghero Jerome, Hatmi Mohamed, Van Dreden Patrick, Gerotziafas Grigoris, Elalamy Ismail P0400 Relation between thrombotic symptoms and fibrin generation kinetics in patients with dysfibrinogenemia Virtudes Vila, Elena Mesa, Saturnino Haya, Ana Cid, Jose Antonio Aznar P0405 Carotid artery thrombosis secondary to penetrating neck trauma Hamid Jiber P0406 The relationship platelet glycoprotein IIb rs 5911 polymorphism and prognostic parameters in female Turkish patients with breast cancer Ilyas Samet Ergün, Hilal Altınöz, Z Oya Uyguner, Nusret Erdoğan, Turay Yardımcı, Şermin Tetik P0407 CHICKENPOX IS NOT ALWAYS BENIGN: POSTVARICELLA PURPURA FULMINANS DUE TO ACQUIRED DEFICIENCY OF PROTEIN S M Angeles Dasi, Bienvenida Argiles, Sara Izquierdo, Magdalena Peinador P0414 Why do children bleed and clot less than adults? Understanding the maturation of the haemostatic system. Vera Ignjatovic, Paul Monagle P0423 The Sonographer and Ultrasound Gel Bosler Frederic P0432 Potential to prevent thrombosis by releasing intrinsic tissue-type plasminogen activator by Enzamin Osamu Matsuo, Yukinori Tamura 13:00-14:00 Posters session (PS3) (Foyer) P0025 Venous thromboembolism and factor V Leiden: enigma or paradox. Francisco Gabriel, Olga Portolés, Manuel Labiós, C Rodriguez, E Cisneros, JR Vela, MJ Nuñez P0026 Contemporary prophylaxis of postoperative venous thromboembolism and monitoring of efficacy: accumulated experience Arshak Vardanyan, Robert Mumladze, Evgeniy Roitman, David Dolidze, Mengkai Shieh P0027 Mondor’s disease in young woman due to hereditary thrombophilia Asya Gusina, Nina Gusina P0043 Association of MDR-1 Gene Polymorphism and Plasma Platelet Activating Factor Levels in Patients with Coronary Artery Disease Turgut Ulutin, Gülsel Ayaz, Bilgehan Karadağ, Gönül Kanıgür, Mehmet Güven, İlhan Onaran, Ahmet Dirican, Barış İlerigelen P0045 Protein C Deficiency in a Family with a History of Childhood Thrombosis Anicee Danaee, Jayanthi Alamelu, David Bevan P0048 Detection and characterization of novel double missense mutations of SERPINC1 in type I inherited antithrombin deficiency Haoyu Deng, Wei Shen, Yi Gu, JiWei Zhang, Jun Xie, YiFeng He, Lan Zhang P0049 Is Serum Uric Acid a Predictor of New-Onset Diabetes in Hypertensive Patients? Gwo-Ping Jong, Tsochiang Ma P0055 Patent Foramen Ovale: A Pathway for Myocardial Infarction in Pregnant Patient – Case Report Ene Mäeots, Merle Kadarik P0073 CLINICAL MANIFESTATION IN HEREDITARY THROMBOPHILIAS AND MANAGENEMT OF THROMBOSIS, PREGNANCY AND DELIVERY Ivo Elezovic, Darko Antic, Predrag Miljic, Mirjana Mitrovic, Valentina Djordjevic, Ljudmila Stojanovic, Olivera Markovic, Mirjana Kovac P0086 High sensitivity of the global CIP assay for hereditary thrombophilia Orsolya Tóth, Jacqueline Conard, Hajna Losonczy, Barbara Réger, Marianne S. Andresen, Marie-Hélene Horellou, Réka Mózes, Ulrich Abildgaard P0091 High levels of D-dimer and previous provoked venous thromboembolism are risk factors for recurrent idiopathic venous thrombosis Monika Stalc, Tjasa Vizintin-Cuderman, Alenka Mavri, Anja Boc P0111 Role of Inherited thrombophilia in Tunisian women with recurrent pregnancy losses Ellouze Rim, Kallel Hajer, Chaker Farah, Ben Said Mehdi, Guermazi Sami P0112 Activated protein C resistance in Tunisian patients with thromboembolic complication or spontaneous recurrent miscarriage Chaker Farah, Ellouze Rim, Ben Said Mehdi, Kallel Hajer, Guermazi Sami P0123 Polymorphisms in the annexin A5 kozak sequence and thrombosis disease in Tunisia Mezni Imen, Sfar Imen, Ellouze Rym, Ben Said Mehdi, Bahloul Abdessalem, Ben Romdhane Thouraya, Makhlouf Mouna, Ayed Jendoubi Saloua, Ben Abdallah Taieb Khaled, Guermazi Sami, Gorgi Yousr P0214 The influense of PAI-1 polyporfism on the platelets and procoagulant parts of the microcoagulation of the blood. Ekaterina Shelest, Maria Matveeva, Ludmila Popova, Lev Patrushev, Igor Bokarev P0136 The Arg6Trp plasmin inhibitor polymorphism: does the presence of the Trp6PI allele contribute to decreased risk of myocardial infarction? Ana Bronic, Goran Ferenčak, Robert Bernat, Jasna Leniček Krleza, Jerka Dumić, Sanja Dabelić P0216 Cytometric assessment of platelet P-selectin expression in patients with sticky platelet syndrom. Peter Kubisz, Peter Chudy, Daniela Chuda, Lenka Bartosova, Jan Stasko P0143 A retrospective study of thrombophilia testing requests in a large teaching hospital Michelle Kint, Sean Platton, Daniel Hart, Peter MacCallum, Laura Green P0152 INCIDENCE OF HAEMORRHAGIC AND THROMBOEMBOLIC COMPLICATIONS IN PATIENTS WITH MECHANICAL HEART VALVE PROSTHESES TAKING LONGTERM VITAMIN K ANTAGONISTS Sanja Gnip, Sladjana Novakovic-Anucin, Visnja Canak, Pavica Radovic, Jelena Kovacev, Milena Scekic, Gorana Mitic P0154 Vicinal thiols are required for activation of the avb3 integrin in endothelial cells Halszka Ponamarczuk, Izabela Papiewska-Pajak, Katarzyna Sobierajska, Maria Swiatkowska P0156 FII, TF, FV and MTHFR gene polymorphisms in the patients, died from influenza A H1N1 (2009) Antony Petrov, Olga Petrova, Nataliya Chartorizhskaya, Nataliya Strambovskaya, Yuri Vitkovsky P0157 Comparison of the Incidence of Treatment Complications of Low Molecular Weight Heparin Use During Pregnancy in Thrombophilic and Non-thrombophilic Women Gorana Mitic, Mirjana Kovac, Aleksandra Novakov Mikic, Djurdjina Jurisic, Iva Salatic P0171 Intracardiac thrombus in Behçet’s disease : A report of 6 cases. Ben Ghorbel Imed, Said Fatma, Belakhel Syrine, Ben Salem Thouraya, Lamloum Mounir, Braham Amel, Khanfir Monia, Hamzaoui Amira, Houman Habib P0182 Dysregulated microRNAs related to angiogenesis expression in endometrial cancer Luis Andrés Ramón, Aitana Braza-Boils, Juan Gilabert-Estellés, Juan Gilabert Aguilar, Melitina Chirivella Casanova, Francisco España Furió, Amparo Estellés Cortés P0192 Efficacy and safety of Fondaparinux in the treatment of pulmonary embolism provoked by Romiplostin: a case report Dimitriy Arioli, Emanuele Negri, Alessia Tieghi, Annamaria Casali, Maria Cristina Leone, Francesca Pileri, Francesco Merli, Ido Iori P0199 LMWH and micronized progesterone in the prevention of repeated obstetric complications in patients with multiple pregnancy and thrombophilia. Viktoriya Bitsadze, Natalya Makatsariya, Dzhamilya Khizroeva P0202 Validation of a Point-of-Care INR Coagulometer in Intensive Care Patients not on Oral Anticoagulant Therapy Bo Joergensen, Karoline Dalgaard, Toke Ravn, Kurt Krogh Knudsen P0203 Simple and rapid method for detection and quenching of DXAI effects Hans-Jürgen Kolde, Ute Lange, Elke Bucha P0207 Factor V Leiden G1691 to A mutation is a prevalent genetic thrombotic risk factor for recurrent pregnancy loss in Tunisian patients Raida Karray-Bradai, Khemais Benhaj, Haykel Trabelsi, Mourad Chaari, Mohamed Guermazi, Choumous Kallel P0211 Activation and balance of coagulation in pregnant women treated with low-molecular weight heparin, administered in therapeutic or preventive dosage Barbara Krevel, Mojca Bozic, Sasa Smid, Matija Kozak P0217 Long-term managing thromboprophylaxis in women with risk pregnancy Rumjana Apostolovska, Ivanka Nikoloska, Violeta Dejanova, Violeta Neceva, Tatjana Makarovska-Bojadzieva P0218 Sticky platelet syndrome in a patient with transitory ischemic attack and her kindreds - case report. Daniela Chuda, Peter Chudy, Lenka Bartosova, Ingrid Skornova, Jan Stasko, Peter Kubisz P0221 RISK FACTORS OF THROMBOSIS IN PATIENTS WITH MAY-THURNER SYNDROME – CASE REPORTS Lenka Bartosova, Ivana Plamenova, Daniela Chuda, Jan Stasko, Peter Kubisz P0222 Therapeutic angiogenesis for critical limb ischemia downregulates platelet reactivity. Peter Chudy, Jan Hudecek, Daniela Chuda, Lubos Hlinka, Renata Talapkova, Jan Stasko, Peter Kubisz P0223 Biermer disease revealed by cerebral venous thrombosis. Djameleddine Benkali, Malika Boucelma, Dalila Zemmour, Nabila Hamzaoui, Samia Lassouaoui, Nacer Ouadahi, Abdelkrim Berrah P0226 Monitoring of hemostasis by thromboelastometry in normal pregnancy Lukas Duraj, Juraj Sokol, Radoslava Simonova, Jan Stasko, Lenka Bartosova, Peter Chudý, Miroslav Hasko, Peter Kubisz P0230 Oral contraceptives and thrombophilia. Jan Stasko, Lenka Bartosova, Peter Chudy, Daniela Chuda, Juraj Sokol, Zuzana Jedinakova, Lukas Duraj, Peter Kubisz P0237 ExACT – Extended anticoagulation treatment for VTE: a randomised trial Gail Heritage, Ellen Murray, Jayne Tullett, David Fitzmaurice P0252 The levels of endothelin-1 in the plasma of patients with peripheral vitreoretinal degeneration Svetlana Serebrennikova, Yuri Vitkovsky P0254 The Effects of Hemolysis and Primary Tube Under-filling on Several Hemostasis Assays; Automatic Detection by the Sysmex CS-2100i* System Jacob de Haan, Joanne McGrath, Eman Ali, Avis Charlton, Hugh Hoogendoorn P0268 Higher risk of Idiopathic small for gestational age newborns in Italian women carrying the Annexin A5 M2 haplotype. Giovanni, Luca Tiscia, Donatella Colaizzo, Giovanni Favuzzi, Giovanna D’Andrea, Patrizia Vergura, Rossana Santacroce, Maurizio Margaglione, Elvira Grandone P0272 Novel role of toll-like receptor 3 in tissue factor activation through erk1/2 pathway in a murine model of hypoxia Indranil Biswas, Iti Garg, Bandana Singh, Gausal Khan P0282 Thrombophilia and placental/chorion abruption in multiple pregnancy after IVF Victoriya Bitsadze, Nataliya Makatsariya, Olga Panfilova, Dzhamilya Khizroeva P0285 RISK FACTORS FOR TE RECURRENCE AFTER ORAL CONTRACEPTIVE ASSOCIATED THROMBOEMBOLISM. Dionysia Theocharidou, Emmanouil Papadakis, Konstantinos Tsepanis, Anastasia Banti, Anna Karagianni, Vaia Papageorgiou, Vassilios Papadopoulos, Vassiliki Pissanidou, Elissavet Georgiou, Anna Kioumi P0291 ANALYSIS OF ABO GROUP IN WOMEN WITH RECURRENT SPONTANEOUS ABORTIONS Aránzazu García Raso, Carolina Miranda, Elham Askari, Rosa Vidal, Raquel Mata, Pilar Llamas P0293 Observational sTudy on antiThrombotic prevention in thrombophILIA and pregnancy loss. The OTTILIA study Michela Villani, Elvira Grandone, Valerio De Stefano, Walter Ageno, Luigi Falasca, Paolo Puggina, Andrea Luigi Tranquilli, Maurizio Margaglione P0345 Obstetric outcomes and thrombotic risk in women approaching ART procedures: a prospective cohort study. Michela Villani, Giovanni, Luca Tiscia, Francesco Dentali, Donatella Colaizzo, Filomena Cappucci, Lucia Fischetti, Walter Ageno, Maurizio Margaglione, Elvira Grandone P0351 In vitro response of thrombin generation (CAT) and fibrin formation (ROTEM) with enoxaparin, dabigatran and rivaroxaban Samama Michel Meyer, Guinet Céline, Le Flem Lena P0303 Immunohistochemical evaluation of the placental tissue in women with thrombophilia and miscarriage Ekaterina Kornyushina, Marina Zainulina, Irina Kostyuchek, Elena Vashukova P0360 Clinical value of thrombophilia diagnostics in women with repeated IVF failure Dzhamilya Khizroeva, Viktoriya Bitsadze, Natalya Makatsariya, Nadezhda Stuleva P0311 Association between patent foramen ovale and cryptogenic ischemic stroke in patients 55 years old or older Accassat Sandrine, Quenet Sara, Comtet Claude, Epinat Magali, Varvat Jérôme, Mismetti Patrick, Garnier Pierre P0364 Long Term Treatment with Nadroparin During Pregnancy and Postpartum Bone Mineral Density Gorana Mitic, Aleksandra Novakov Mikic, Jovanka Novakovic Paro, Dragana Popov, Sladjana Novakovic Anucin, Visnja Canak, Sanja Gnip, Dragan Spasic, Branka Kovacev Zavisic P0312 Electronic alerts improve adherence and adequacy of VTE prophylaxis in a tertiary care hospital from Cordoba, Argentina Aldo Hugo Tabares, Guadalupe Caballero Escuti,, María Teresita Cornavaca, Francisco Bernabeu, María Eugenia Garzón Oliva, Ana Soledad Vergottini, Romina Ivana Benkovic, Ricardo Arturo Albertini P0365 Mortality clinical predictor factors in the pulmonary embolism patients Mireia Feliu Masgoret, Francesc Marimon Cortés, Alexander Córdoba Castro, Patricia Sahún Gómez, Jordi Merino Ribas, Sandra Parra Pérez, Raimon Ferré Vallès, Antoni Castro Salomó P0314 The progress ways in the improvement of IVF results based on revealing hemostasis pathology and its correction Andrey Momot, Inna Lydina, Ludmila Tsyvkina, Galina Serduk, Oksana Borisova P0378 TIME IN THERAPEUTIC RANGE AND COMPLICATIONS OF ANTITHROMBOTIC TREATMENT Pavica Radovic, Jelena Kovacev, Sladjana Novakovic-Anucin, Sanja Gnip, Visnja Canak, Gorana Mitic P0319 Decreased Threshold of Aggregation to Low-Dose Epinephrine is Evidence of “Platelet Hyperaggregability” in Patients with Thrombosis Chelsea Hayes, Sumire Kitahara, Oxana Tcherniantchouk P0379 Several polymorphisms in the ADAMTS13 gene in a patient with thrombotic thrombocytopenic purpura (TTP) Julio Cesar Calderazzo, Ana Catalina Kempfer, Juvenal Paiva, Analia Sanchez-Luceros, Adriana Inés Woods, María Angela Lazzari P0324 Can the previous therapeutic control of the main risk factors to cerebrovascular disease influence the acetylsalicylic acid-non responsive status in acute ischemic stroke patients? Margarida Freitas-Silva, Luciana Gonçalves, Rui Medeiros, Jose Pedro Nunes P0387 Thrombophilia in systemic lupus erythematosus: a casecontrol study Smiti Khanfir Monia, Belfeki Nabil, Hamzaoui Amira, Ben Salem Thouraya, Mahjoub Sonia, Keddous Asma, Ben Romdhane Neila, Houman Mohamed Habib P0326 The prevalence of congenital and acquired thrombophilia and hyperhomocysteinemia in women with repeated in vitro fertilization failure. Marina Zaynulina, Marina Mirashvili P0327 Thromboembolism prophylaxis after cesarean section (PRO-CS) Trial Farjah Algahtani, Hessa Al Dohami, Saud Abo-Harbesh, Abdel Galil Abdel Gader, Aamer Aleem P0330 Optimizing centrifugation conditions for preparing Platelet Concentrates Mojgan Pourmokhtar, Ebadollah Salek Moghaddam, Fatemeh Abbasi, Soudabeh Banazadeh P0331 ADAMTS-13 and the platelets activity of the microcoagulation of the blood at the PAI-1 polyporfism. Maria Matveeva, Ekaterina Shelest, Ludmila Popova, Lev Patrushev, Igor Bokarev P0334 Influence of a contraceptive vaginal ring delivering Etonogestrel and Ethinyl Estradiol and a combined oral contraceptive containing Ethinyl Estradiol and Dezogestrel on coagulation and platelet activation. Veronika Shmeleva, Ludmila Papayan, Natalia Aganezova P0339 An automated antithrombin antigen assay on Instrumentation Laboratory ACL TOP analyser Peter Cooper, Kieron Hickey, Fiona Coath, Mike Makris P0340 An automated progressive assay of antithrombin Peter Cooper, Kieron Hickey, Fiona Coath, Mike Makris P0394 STROKE IN SICKLE CELL ANEMIA: A Case Report Yurdanur Kilinç, Barbaros Şahin Karagün, Esra Pekoak, İlgen Şaşmaz P0403 Prevalence of FV Leiden, prothrombin FII 20210G>A, PAI-1 (SERPINE1) 4G/5G, GPVI 13254T>C, SERPINC1 ( IVS +141G>A) and CYP4V2 Lys259Gln in Czech Republic. Jan Kvasnicka, Jaroslava Hajkova, Petra Bobcikova, Tomas Kvasnicka, Daniela Duskova, Zdenek Krska P0417 How we manage antithrombotic treatment in pregnancy high risk thrombotic situations: Beatriz E Grand, Maria Monica Gonzalez Alcantara, Geraldine Voto, Liliana S Voto P0420 EFFECTIVE OUTCOME OF PREGNANCIES IN CASES OF RECURRENT FETAL LOSSES A. Foifa, MP. Makris, PE. Makris P0421 Pregnancy outcomes in women with inherited bleeding disorders (IBD) in a public hospital: Beatriz E Grand, Maria Monica Gonzalez Alcantara, Guadalupe Madrid, Geraldine Voto, Liliana S Voto Join the MLTD! Visit our booth and discover the advantages to be member of the MLTD The society aims to create bridges between clinical practice and basic science, bringing together research scientists on vascular and molecular biology and clinicians of many different disciplines such as Hematology, Cardiology, Neurology, Angiology, Surgery, Internal Medicine, Gynecology and other disciplines related to Thrombosis, currently the main cause of mortality in the western world. The Society contributes to the translation of scientific advances to clinical practice with a multidisciplinary and international approach, organizing international congresses on Thrombosis, Educational Courses and Symposia oriented to the advance in the fight against Thrombosis. - Discounted rates for Members in the biannual International Congresses on Thrombosis and other scientific activities that the MLTD will organize. - Online subscription to our official Journal, Thrombosis Research - To be nominated and to receive Society and Congress Awards www.medleague-thrombosis.org MLTD General Secretary Mª Teresa Santos Ph. D. Research Center. University Hospital "La Fe" Avda Campanar, 2146009 Valencia (SPAIN) santos_ter@gva.es GRUPO GEYSECO MLTD Technical Secretariat Universidad, 4 46003 Valencia (SPAIN) tel. (+34) 963 524 889 fax. (+34) 963 942 558 mltd@geyseco.es { Changing landscape in anticoagulation – new perspectives and treatment strategies Satellite Symposium The 22nd International Congress on Thrombosis (ICT) Sunday, 7 October 2012 12:45-13:45 ‘Hermes’ room, Acropolis, Nice, France Lunch will be provided 12:45 WELCOME & INTRODUCTION Chair: Professor Patrick Mismetti, Saint-Etienne, France 12:50 NOVEL ANTICOAGULANTS – NEW PERSPECTIVES IN ATRIAL FIBRILLATION Professor José Luis Zamorano, Madrid, Spain 13:05 CURRENT LANDSCAPE OF VENOUS THROMBOEMBOLISM – THE CLINICIAN’S VIEW Professor Patrick Mismetti, Saint-Etienne, France 13:25 NEW DIRECTIONS IN VENOUS THROMBOEMBOLISM MANAGEMENT Professor Walter Ageno, Varese, Italy 13:35 PANEL DISCUSSION & MEETING CLOSE All www.epicea.com - Photo : Shutterstock - ©2011 Diagnostica Stago - All rights reserved - Non-contractual photos - 09/2012 Generate Performance Stago, worldwide reference in Haemostasis • Integrated solutions, well known for their reliability (analysers, reagents, consumables) • Innovations designed to facilitate the daily laboratory practice • Extensive range of tests for both routine and research settings • Performance-boosting services and environment (interconnectivity, technical assistance, diagnostic and accreditation support, EQA, training, logistics, etc.) • Recognised by the international scientific community for its expertise • Global network ensuring fast, local service in over 110 countries Diagnostica Stago S.A.S RCS Nanterre B305 151 409 9, rue des Frères Chausson 92600 Asnières sur Seine (France) Ph. +33 (0)1 46 88 20 20 Fax +33 (0)1 47 91 08 91 webmaster@stago.com www.stago.com Venue Plan AUDITORIUM ATHÉNA ROOM GALLIENI 5 16 COMMERCIAL EXHIBITION POSTERS ZONE A B C RHODES ROOM PREVIEW ROOM AUDITORIUM HERMÉS ENTRANCE TECHNICAL SECRETARIAT 03 01 11- 12 04 13-14 05 16 A INFORMATION DESK B MLTD C BUSINESS CENTER 07-08 18 09-10 19 Sponsor Profiles BAYER HEALTHCARE Contact: Olivier Morboeuf Medical adviser E-mail:olivier.morboeuf@bayer.com Mobile: + 33 6 21 02 46 79 Bayer HealthCare is among the world’s foremost innovators in the field of pharmaceutical and medical products. This subgroup’s mission is to research, develop, manufacture and market innovative products that improve the health of people and animals throughout the world. The globally operating Health Care subgroup is divided into four operating divisions: The goals of the Animal Health Division are to maintain the health of animals and cure veterinary diseases, with the focus primarily on treating infectious diseases and repelling parasites. The main focus of the Consumer Care Division is on non-prescription medicines and dietary supplements. One example is Aspirin, a more than 110-year-old brand that enjoys an unsurpassed level of global familiarity. Medical Care comprises the businesses with blood glucose monitoring devices and medical equipment for diagnosis and treatment. The Pharmaceuticals Division is today the highest-selling pharmaceuticals company in Germany and holds a worldwide leading position in its main therapeutic areas. The focus is on prescription medicines. The division combines its strengths in two business units: General Medicine and Specialty Medicine. BOEHRINGER-INGELHEIM www.boehringer-ingelheim.com The Boehringer Ingelheim group is one of the world’s 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 145 affiliates and more than 44,000 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel medications of high therapeutic value for human and veterinary medicine. As a central element of its culture, Boehringer Ingelheim pledges to act socially responsible. Involvement in social projects, caring for employees and their families, and providing equal opportunities for all employees form the foundation of the global operations. Mutual cooperation and respect, as well as environmental protection and sustainability are intrinsic factors in all of Boehringer Ingelheim’s endeavors. In 2011, Boehringer Ingelheim achieved net sales of about 13.2 billion euro. R&D expenditure in the business area Prescription Medicines corresponds to 23.5% of its net sales. DAIICHI-SANKYO The Daiichi Sankyo Group is dedicated to the creation and supply of innovative pharmaceutical products to address the diversified, unmet medical needs of patients in both mature and emerging markets. The company was created in 2005 through the merger of two traditional Japanese enterprises, Daiichi and Sankyo. With net sales of more than €8.6 billion, Daiichi Sankyo is one of the world’s 20 leading pharmaceutical companies. The company’s world headquarters are in Tokyo. Its European base is located in Munich. Daiichi Sankyo Europe has affiliates in 12 European countries in addition to a global manufacturing site located in Pfaffenhofen, Germany. DSM Contact: Mr. Michael Janssen The Branch Pentapharm, since 2007 part of DSM, is a manufacturer of haemeostasis diagnostics: Test kits e.g. Pefakit® APC-R Factor V Leiden, PiCT® (for UFH, LMWH and/or anti-FIIa and FXa drug monitoring), Reptilase Time, in-TDT® (for thrombin generation), or OEM products. Reagents (from research to bulk quantities) including customer manufacturing n: synthetic chromogenic, fluorogenic and amperogenic substrates, protease inhibitors and snake venom enzymes. Active pharmaceutical ingredients: aprotinin, peptides and snake venom derived enzymes (Batroxobin, Haemocoagulase ) and synthesis of peptides and small organic molecules. INTRUMENTATION LABORATORY Instrumentation Laboratory (IL) is passionate about delivering the most innovative solutions to address a range of hemostasis testing needs. The advanced ACL™ family of systems brings complete automation to the hemostasis lab—including the ACL TOP® Family of Hemostasis Testing Systems, featuring the new ACL TOP 300 CTS; and, the ACL AcuStar®, the first fully automated, chemiluminescent analyzer for hemostasis specialty testing. Combined with the HemosIL line of reagents, a comprehensive panel of fully automated assays, IL offers complete disease state management for the hemostasis lab. LEO PHARMA www.leo-pharma.com www.leo-pharma.fr Founded in 1908, LEO Pharma is an independent, research-based pharmaceutical company based in Ballerup near Copenhagen. LEO Pharma is wholly owned by the LEO Foundation. LEO Pharma develops, manufactures and markets competitive drugs for thrombosis patients and in dermatology in more than 100 countries. LEO Pharma has offices in 61 countries and employs more than 5000 employees worldwide. LFB GROUP The LFB group is a biopharmaceutical company that develops, manufactures and markets medicinal products for serious and often rare diseases, in three major therapeutic areas: immunology, hemostasis and intensive care. Leader in France and 6th player worldwide in the field of plasma-derived medicinal products, the LFB Group also is a leading European company in the development of monoclonal antibodies and new generation proteins derived from biotechnologies. With its strong research activities, the LFB group is developing a growth strategy to expand its business activities by offering new therapeutic treatments and expanding into new international markets. ROCHE www.roche.com Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world’s largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche’s personalized healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2011, Roche had over 80,000 employees worldwide and invested over 8 billion Swiss francs in R&D. The Group posted sales of 42.5 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. ROVI Address: Julian Camarillo, 35 28037 Madrid (Spain) Telephone: 913756230 Fax: 913047881 E-mail: rovi@rovi.es www.rovi.es ROVI is a fully-integrated, profitable Spanish specialty pharmaceutical company engaged in the research, development, in-licensing, manufacturing and marketing of small molecule and specialty biologic drugs. The Company has a diversified portfolio of products that it markets in Spain through its specialized sales force, calling on specialist physicians, hospitals and pharmacies. ROVI’s portfolio of 30 principal marketed products is currently anchored by the internally-developed, second generation low molecular weight heparin, Bemiparin which is also out-licensed and marketed in 50 countries thanks to a network of partners. ROVI’s research and development pipeline is focused primarily on addressing currently unmet medical needs by developing new Bemiparin indications and the novel ISM (“in-situ microparticles”) technology for injectable forms. SIEMENS Siemens Healthcare Diagnostics Products GmbH Contact: Michael Nöh Vice President BU HHS Global Marketing Address: Emil-von-Behring-Straße 76 35041 Marburg (Germany) E-mail: michael.noeh@siemens.com www.siemens.com/healthcare Siemens Healthcare Diagnostics offers a comprehensive portfolio of performance-driven systems, unmatched test menu, and information technology solutions for the in vitro diagnostic needs of hospital labs, reference labs, physician office labs, and point-of-care testing. We provide clinicians with the vital information they need for accurate diagnosis, treatment, and monitoring of patients. Our diagnostic solutions — chemistry, immunoassay, automation, hematology, hemostasis, microbiology, diabetes, urinalysis, blood gas, and molecular testing — are designed to streamline workflow, enhance operational efficiency, and support improved patient care. STAGO Stago dedicates its research and innovative skills to develop and improve the accuracy of the medical diagnostic. The firm formulates, manufactures and markets worldwide, a broad range of reagents and fully automated systems for Haemostasis & Thrombosis. Thanks to its Haemostasis expertise, Stago is recognized and is in a position to cooperate with the scientific community worldwide. Sponsors GOLD SPONSOR SILVER SPONSOR BRONZE SPONSOR SPONSORS OFFICIAL JOURNAL MEDIA PARTNER 5 VOLUME 130, ISSUE 4 OCTOBER 2012 ISSN 0049-3848 THROMBOSIS RESEARCH THROMBOSIS RESEARCH Anti-Xa range VOLUME 130, ISSUE 4, PAGES 571–692 www.epicea.com - Photo : Eric Meola/Gettyimages - ©2011 Diagnostica Stago - All right reserved - No contractual photos - 01/2012 130 4 Connecting the World of Biomedical Science STA®-Liquid Anti-Xa OCTOBER 2012 The solution for UFH, LMWH and Fondaparinux monitoring Liquid format, easy to use and reproducible Medical and Scientific Publishers Fully automated assay Wide working range and increased on-board stability Dedicated and hybrid calibrations available ELSEVIER Diagnostica Stago S.A.S RCS Nanterre B305 151 409 9, rue des Frères Chausson 92600 Asnières sur Seine (France) Ph. +33 (0)1 46 88 20 20 Fax +33 (0)1 47 91 08 91 webmaster@stago.com www.stago.com Available online at www.sciencedirect.com TECHNICAL SECRETARIAT Tel.: +34 96 352 48 89 Fax: +34 96 394 25 58 www.geyseco.es