Common Name: SAFETEX CYTOLOGY FIXATIVE FSPI

Common Name:
SAFETEX CYTOLOGY FIXATIVE FSPI
Manufacturer: ANDWIN SCIENTIFIC
Revision: (No Data Listed)
MATERIAL SAFETY DATA SHEET
1. IDENTIFICATION
PRODUCT NAME:
SAFETEX CYTOLOGY FIXATIVE FSP1
ANDWIN SCIENTIFIC
6636 VARIEL AVE
CANOGA PARK, CA 91303
(818) 999-2828
IN CASE OF EMERGENCY CONTACT ANDWIN AT (800) 497-3113
CHEMICAL NAME:
FORMULA:
SOLUTION OF:
95% (CH3)2CHOH
3% H2O
2% HO-(CH2CH2O)n-H
MOLECULAR WEIGHT:
SYNONYMS:
95% ISOPROPANOL
3% DISTILLED WATER
2% POLYETHYLENE GLYCOL 1450
1510.10
95% 2-PROPANOL,SEC-PROPYL ALCOHOL, ISOPROPANOL
3% DISTILLED WATER
2% POLYETHYLENE GLYCOL 1450
CAS# AND NAME:
95% ISOPROPYL ALCOHOL (67-63-0)
3% DISTILLED WATER (007732-18-5)
2% POLY(OXY-1,2-ETHANEDIYL), A-HYDRO-W-HYDROXY-
2. PHYSICAL DATA
BOILING POINT:
86 DEGREES C (187 DEGREES F)
SPECIFIC GRAVITY (H2O=1):
0.79
FREEZING POINT:
-85C (-121F)
VAPOR PRESSURE AT 20 DEG. C:
30 MMHG (ESTIMATED BASED ON ISOPROPYL ALCOHOL)
VAPOR DENSITY (AIR =1):
2.0 (ESTIMATED BASED ON ISOPROPYL ALCOHOL)
EVAPORATION RATE
(BUTYL ACETATE =1):
2.5 (ESTIMATED BASED ON ISOPROPYL ALCOHOL)
SOLUBILITY IN WATER BY WT.:
INFINITIVE IN WATER
APPEARANCE:
CLEAR, COLORLESS LIQUID
ODOR:
RUBBING ALCOHOL
PHYSICAL STATE:
LIQUID
PRECAUTIONARY MEASURES
WARNING! FLAMMABLE LIQUID, HARMFUL IF SWALLOWED OR INHALED, AFFECTS CENTRAL
NERVOUS SYSTEM, CAUSES IRRITATION.
KEEP AWAY FROM HEAT, SPARKS AND FLAME. KEEP CONTAINER CLOSED. USE WITH
ADEQUATE VENTILATION. AVOID BREATHING VAPOR. WASH THOROUGHLY AFTER
HANDLING.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
EMERGENCY FIRST AID
IF SWALLOWED, GIVE WATER TO DRINK. INDUCE VOMITING IF MEDICAL HELP IS NOT
IMMEDIATELY AVAILABLE. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS
PERSON.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IN CASE OF CONTACT,
IMMEDIATELY FLUSH SKIN OR EYES WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES.
IN ALL CASES CALL A PHYSICIAN. SEE SECTION 6.
DOT HAZARD CLASS:
NFPA RATINGS:
FLAMMABLE LIQUID
HEALTH:
FLAMMABILITY:
REACTIVITY:
1
3
0
FIRE AND EXPLOSION: FLAMMABLE LIQUID FLASH POINT: 12 c (53F),(CLOSED CUP).
AUTO IGNITION TEMPERATURE: 399 C (750F). FLAMMABLE LIMITS IN AIR,% BY
VOLUME:
LEL: 2.0; EUL: 12.0
SECTION 3
EXPLOSION: ABOVE FLASH POINT, VAPOR-AIR MIXTURES ARE EXPLOSIVE WITHIN
FLAMMABLE LIMITS NOTED ABOVE. CONTACT WITH STRONG OXIDIZERS MAY CAUSE FIRE
OR
EXPLOSION.
FIRE EXTINGUISHING: MEDIA: WATER SPRAY, DRY CHEMICAL, ALCOHOL FOAM, OR
CARBON
DIOXIDE. WATER SPRAY MAY BE USED TO KEEP FIRE EXPOSED CONTAINERS COOL.
SPECIAL INFORMATION: IN THE EVENT OF A FIRE, WEAR FULL PROTECTIVE CLOTHING
AND
NIOSH-APPROVED SELF-CONTAINED BREATHING APPARATUS WITH FULL FACE PIECE
OPERATED
IN THE PRESSURE DEMAND OR OTHER POSITIVE PRESSURE MADE. WATER MAY BE USED TO
FLUSH SPILLS AWAY FROM EXPOSURES AND TO DILUTE SPILLS TO NON-FLAMMABLE
MIXTURES. VAPORS CAN FLOW ALONG SURFACES TO DISTANT IGNITION SOURCE AND
FLASH
BACK.
SECTION 4
REACTIVITY DATA: STABLE UNDER ORDINARY CONDITIONS OF USE AND STORAGE.
AND SUNLIGHT CAN CONTRIBUTE TO INSTABILITY.
HEAT
HAZARDOUS-DECOMPOSITION PRODUCTS: TOXIC GASES AND VAPORS SUCH AS CARBON
MONOXIDE MAY BE RELEASED IN A FIRE INVOLVING ISOPROPYL ALCOHOL.
HAZARDOUS POLYMERIZATION:
WILL NOT OCCUR.
INCOMPATIBILITIES: HEAT, FLAME STRONG OXIDIZERS, ACETALDEHYDE, CHLORINE,
ETHYLENE OXIDE, HYDROGEN-PALLADIUM COMBINATION, HYDROGEN PEROXIDE-SULFURIC
ACID
COMBINATION, POTASSIUM TERT-BUTOXIDE, HYPOCHLOROUS ACID, ISOCYANATES,
NITROFORM, PHOSGENE, OLEUM AND PERCHLORIC ACID.
SECTION 5
LEAK/SPILL DISPOSAL INFORMATION:
REMOVE ALL SOURCES OF IGNITION. VENTILATE AREA OF LEAK OR SPILL. CLEAN-UP
PERSONNEL REQUIRE PROTECTIVE CLOTHING AND RESPIRATORY PROTECTION FROM VAPORS.
SMALL SPILLS MAY BE ABSORBED ON PAPER TOWELS AND EVAPORATED IN A FUME HOOD.
ALLOW ENOUGH TIME FOR FUMES TO CLEAR HOOD, THEN IGNITE PAPER IN A SUITABLE
LOCATION AWAY FROM COMBUSTIBLE MATERIALS. CONTAIN AND RECOVER LIQUID FOR
RECLAMATION WHEN POSSIBLE. LARGER SPILLS AND LOT SIZES CAN BE COLLECTED AS
HAZARDOUS WASTE AND ATOMIZED IN A SUITABLE RCRA APPROVED COMBUSTION CHAMBER,
OR
ABSORBED WITH VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL FOR DISPOSAL
AS
HAZARDOUS WASTE IN A RCRA APPROVED FACILITY.
ENSURE COMPLIANCE WITH LOCAL, STATE AND FEDERAL REGULATIONS.
SECTION 6
HEALTH HAZARD INFORMATION:
A. EXPOSURE/HEALTH EFFECTS
INHALATION: MAY CAUSE IRRITATION OF THE NOSE AND THROAT. EXPOSURE TO HIGH
CONCENTRATIONS HAS A NARCOTIC EFFECT, PRODUCING SYMPTOMS OF DROWSINESS,
HEADACHE, STAGGERING, UNCONSCIOUSNESS AND POSSIBLY DEATH.
INGESTION: MAY CAUSE DROWSINESS, UNCONSCIOUSNESS, AND DEATH.
GASTROINTESTINAL
PAIN, CRAMPS, NAUSEA, VOMITING, AND DIARRHEA MAY ALSO RESULT. THE SINGLE
LETHAL DOSE FOR HUMAN ADULT=ABOUT 250 mls (SAX SIXTH EDITION).
SKIN CONTACT: HAS A DEFATTING ACTION OF THE SKIN THAT CAN CAUSE IRRITATION.
MAY CAUSE IRRITATION WITH A STINGING EFFECT AND BURNING SENSATION.
EYE CONTACT: VAPORS MAY IRRITATE THE EYES. SPLASHES MAY CAUSE SEVERE
IRRITATION, DRYING, CRACKING, OR CONTACT DERMATITIS MAY DEVELOP.
CHRONIC EXPOSURE: PROLONGED CONTACT WITH SKIN MAY CAUSE MILD IRRITATION,
DRYING, CRACKING, OR CONTACT DERMATITIS MAY DEVELOP.
AGGRAVATION OF PRE-EXISTING CONDITIONS: PERSONS WITH PRE-EXISTING SKIN
DISORDERS OR EYE PROBLEMS OR IMPAIRED RESPIRATORY FUNCTION MAY BE MORE
SUSCEPTIBLE TO THE EFFECTS OF THE SUBSTANCE.
B. FIRST AID
INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. CALL A PHYSICIAN.
INGESTION: GIVE WATER TO DRINK. INDUCE VOMITING IF MEDICAL HELP IS NOT
IMMEDIATELY AVAILABLE. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS
PERSON.
GET MEDICAL ATTENTION IMMEDIATELY.
SKIN EXPOSURE: REMOVE ANY CONTAMINATED CLOTHING. WASH SKIN WITH SOAP OR
MILD
DETERGENT AND WATER FOR AT LEAST 15 MINUTES. GET MEDICAL ATTENTION IF
IRRITATION DEVELOPS OR PERSISTS.
EYE EXPOSURE: WASH EYES WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES,
LIFTING
LOWER AND UPPER EYELIDS OCCASIONALLY. GET MEDICAL ATTENTION IMMEDIATELY.
C. TOXICITY: (RTECS, 1986)
ORAL RAT LD50: 5840 MG/KG. SKIN RABBIT LD50: 13 GM/KG. INHALATION RAT LC50:
16000 PPM/8H. MUTATION REFERENCES CITED AQUATIC TOXICITY RATING.
TLM96: 1000-10 PPM
SECTION 7
OCCUPATIONAL CONTROL MEASURES
AIRBORNE EXPOSURE LIMITS:-OSHA PERMISSIBLE EXPOSURE LIMIT(PEL): 400 PPM
(TWA),
500 PPM (STEL)-ACGIH THRESHOLD LIMIT VALVE(TLV): 400 PPM (TWA), 500 PPM
(STEL)
VENTILATION SYSTEM:
TO
A SYSTEM OF LOCAL AND/OR GENERAL EXHAUST IS RECOMMENDED
KEEP EMPLOYEE EXPOSURES BELOW THE AIRBORNE EXPOSURE
LIMITS. LOCAL EXHAUST VENTILATION IS GENERALLY
PREFERRED
BECAUSE IT CAN SOURCE, PREVENTING DISPERSION OF IT INTO
THE GENERAL WORK AREA. PLEASE REFER TO THE ACGIH
DOCUMENT, "INDUSTRIAL VENTILATION A MANUAL OF
RECOMMENDED
PRACTICES", MOST RECENT EDITION, FOR DETAILS.
PERSONAL RESPIRATORS:
(NIOSH APPROVED)
THE
IF THE TLV IS EXCEEDED A FULL FACE PIECE CHEMICAL
CARTRIDGE RESPIRATOR MAY BE WORN, IN GENERAL, UP TO
MAXIMUM USE CONCENTRATION SPECIFIED BY THE RESPIRATOR
SUPPLIER.
ALTERNATIVELY, A SUPPLIED AIR FULL FACE
PIECE
RESPIRATOR OR AIRLINED HOOD MAY BE WORN.
SKIN PROTECTION:
GLOVES,
WEAR IMPERVIOUS PROTECTIVE CLOTHING, INCLUDING BOOTS,
LAB COAT, APRON OR COVERALLS TO PREVENT SKIN CONTACT.
EYE PROTECTION:
USE CHEMICAL SAFETY GOGGLES AND/OR A FULL FACE SHIELD WHERE
SPLASHING IS POSSIBLE. CONTACT LENSES SHOULD NOT BE WORN
WHEN WORKING WITH THIS MATERIAL. MAINTAIN EYE WASH FOUNTAIN
AND QUICK-DRENCH FACILITIES IN WORK AREA.
SECTION 8
STORAGE AND SPECIAL INFORMATION
PROTECT AGAINST PHYSICAL DAMAGE. STORE IN A COOL, DRY WELL-VENTILATED
LOCATION, AWAY FROM ANY AREA WHERE THE FIRE HAZARD MAY BE ACUTE. CUTSIDE OF
DETACHED STORAGE IS PREFERRED. SEPARATE FROM OXIDIZING MATERIALS.
CONTAINERS
SHOULD BE BONDED AND GROUNDED FOR TRANSFERS TO AVOID STATIC SPARKS. STORAGE
AND USE AREAS SHOULD BE NO SMOKING AREAS. USE NON-SPARKING TYPE TOOLS AND
EQUIPMENT.
ADDENDUM TO MATERIAL SAFETY DATA SHEET REGULATORY STATUS
THIS ADDENDUM MUST NOT BE DETACHED FROM THE MSDS IDENTIFIES SARA 313
SUBSTANCE(S) ANY COPYING OR REDISTRIBUTION OF THE MSDS MUST INCLUDE A COPY OF
THIS ADDENDUM.
HAZARD CATEGORIES FOR SARA SECTION 311/312 REPORTING
ACUTE
X
CHRONIC
X
PRODUCT OR COMPONENTS
OF PRODUCT:
PROPYLENE GLYCOL
(0000-57-55-6)
ISOPROPYL ALCOHOL
(67-63-0)
FIRE
X
PRESSURE
REACTIVE
SARA EHS
SEC.302
RQ
TPQ
SARA SEC. 313
CHEMICALS
NAME
CHEMICAL
LIST
CATEGORY
CERCLA
SEC.103
RQ lbs
RCRA
SEC.
261.33
NO
NO
YES
NO
NO
NO
NO
NO
YES
NO
NO
NO
SARA SECTION 302 EHS RQ:
REPORTABLE QUANTITY OF EXTREMELY HAZARDOUS SUBSTANCE, LISTED AT 40 CFR 355.
SARA SECTION 302 EHS TPQ:
THRESHOLD PLANNING QUANTITY OF EXTREMELY HAZARDOUS SUBSTANCE. AN ASTERISK
(*)
FOLLOWING A THRESHOLD PLANNING QUANTITY SIGNIFIES THAT IF THE MATERIAL IS A
SOLID AND HAS A PARTICLE SIZE EQUAL TO OR LARGER THAN 100 MICROMETERS, THE
THRESHOLD PLANNING QUANTITY = 10,000 LBS.
SARA SECTION 313 CHEMICALS:
TOXIC SUBSTANCES SUBJECT TO ANNUAL RELEASE REPORTING REQUIREMENTS LISTED AT
40
CFR 372.65
CERCLA SEC. 103:
COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION AND LIABILITY ACT
(SUPERFUND) RELEASES TO AIR, LAND OR WATER OF THESE HAZARDOUS SUBSTANCES
WHICH
EXCEED THE REPORTABLE QUANTITY (RQ) MUST BE REPORTED TO THE NATIONAL RESPONSE
CENTER, (800-424-8802) LISTED AT 40 CFR 302.4
RCRA:
RESOURCE CONSERVATION AND RECLAMATION ACT. COMMERCIAL CHEMICAL PRODUCT
WASTES
DESIGNATED AS ACUTE HAZARDS AND TOXIC UNDER 40 CFR 261.33
MSDS – CytoLyt® Solution
1. CHEMICAL AND COMPANY IDENTIFICATION
Product Identification:
CytoLyt® Solution
Trade Name/Chemical Family/Synonyms:
Product Description:
Methanol-water solution
A methanol based, buffered preservative solution
Product Use:
A preservative solution to support cells during transport and slide preparation.
Manufacturer
Cytyc Corporation
250 Campus Drive
Marlborough, Massachusetts 01752
USA
Telephone: 800-442-9892
EMERGENCY TELEPHONE NUMBERS:
(24 hours a day and 7 days a week)
CYTYC P/N 85092-001 Rev. I.
For distribution by Cytyc US
For Health/Transportation/Chemical Spills
(Multilingual capabilities and free calls accepted)
Continental United States: (800) 424-9300
Outside of continental United States: +(703) 527-3887
Page 1 of 6
MSDS – CytoLyt ® Solution
2. COMPOSITION/INFORMATION ON INGREDIENTS
Component
Methanol
Water
CAS Registry #
67-56-1
7732-18-5
Wt. %
20 – 50
40 – 70
3. HAZARDS IDENTIFICATION:
EMERGENCY
OVERVIEW:
Material is a clear flammable liquid. Inhalation of vapors may cause nonspecific discomfort
(nausea, weakness), drowsiness with anesthetic effects and possible blindness. Swallowing as
little as 10 ounces (296 ml) may cause blindness and in extreme cases death.
Potential Health Effects.
Inhalation:
May cause depression of central nervous system resulting in nausea, weakness, drowsiness and
possibly blindness.
Eye Contact:
May cause transient irritation.
Skin Contact:
May cause irritation and/or dermatitis. Material may be absorbed through the skin resulting in
effects similar to ingestion or inhalation.
Ingestion:
May cause intoxication, Central nervous system depression, nausea, and dizziness. May
damage liver, kidneys and nervous system. May cause blindness and/or death.
Target Organs:
Liver, kidneys, and central nervous system.
CYTYC P/N 85092-001 Rev. I.
For distribution by Cytyc US
Page 2 of 6
MSDS – CytoLyt ® Solution
Medical Conditions
Aggravated by Exposure:
Individuals with preexisting diseases of the retina (eyes) or liver may have increased
susceptibility to toxicity at lower levels of successive exposure (repeated exposures).
Chronic:
Liquid and vapor can penetrate skin and mucous membranes. May cause chronic
liver, kidney or nervous system disorders.
4. FIRST AID MEASURES:
Inhalation:
Remove patient to fresh air. If symptoms of intoxication or vision problems are apparent, get
immediate medical aid.
Eye Contact:
Immediately flush with clean water for at least 15 minutes. Get medical aid.
Skin Contact:
Remove contaminated clothing and shoes. Flush affected area with copious amounts of water.
If irritation or other symptoms are present, get immediate medical assistance.
Ingestion:
Do Not Induce Vomiting. Give one or two glasses of water and get immediate medical aid.
Notes to Physician:
Treat for CNS depression and possible renal failure.
5. FIRE FIGHTING MEASURES:
Flashpoint and Method:
109ºF
(42.7ºC)
Autoignition Temperature:
725ºF
(385ºC) (based on methanol component)
Flammable Limits:
LEL-6.7 UEL-36
General Hazard:
Flammable material. Heated material may form toxic and/or explosive vapors.
Fire Fighting Instructions:
Wear full turnout gear with self-contained breathing apparatus. If material is not involved
in fire, attempt to cool with water or remove from area. FLAME INVISIBLE IN
DAYLIGHT.
Fire Fighting Equipment:
Wear full turnout gear with self-contained breathing apparatus.
Extinguishing Media:
Foam – Yes
Water – Yes
Hazardous Combustion Products:
(based on methanol component)
Alcohol Foam – Yes
Other – Water Fog
C02 – Yes
Dry Chemical – Yes
Carbon Monoxide and Carbon Dioxide
Health – 1
Flammability – 2
Reactivity – 0
Special Information – None
NFPA Hazard Rating:
(National Fire Protection
Association)
Special Information:
Closed cup
0=Insignificant
1=Slight
2=Moderate
3=High
4=Extreme
U=Unknown *=No Information
None
CYTYC P/N 85092-001 Rev. I.
For distribution by Cytyc US
Page 3 of 6
MSDS – CytoLyt ® Solution
6. ACCIDENTAL RELEASE MEASURES:
Land Spill
Prevent runoff from entering waterways. Dyke large spills with clay. Absorb small spills with clay or kitty
litter. For spills in excess of 50 gallons, contact licensed HAZWOPER responders.
Water Spill:
Follow local, state and Federal guidelines and regulations.
Follow Local, State and Federal Guidelines for all spills.
7. HANDLING AND STORAGE:
Handling:
KEEP OUT OF THE REACH OF CHILDREN. Wear recommended personal protective equipment and
avoid contact with skin and eyes.
Storage:
Store away from excessive heat and sources of ignition. Keep containers closed and protect from damage.
Storage Temperatures: Without cytologic sample: 59 – 86 ºF (15 – 30ºC)
8. EXPOSURE CONTROLS / PERSONAL PROTECTIVE EQUIPMENT:
Engineering Controls:
Supply exhaust and/or ventilation to keep vapor levels below threshold limit value.
Respirator:
Where engineering controls are not adequate, use approved NIOSH respirators or supplied
air respirators.
Protective Clothing:
Chemically resistant gloves and eye protection.
Exposure Limits for Ingredients:
Ingredient
OSHA PEL
Methanol
200 ppm – TWA
ACGIH TLV®
200 ppm – TWA
250 ppm – STEL
Skin
TWA – 8 hr
STEL – 15 minute
9. PHYSICAL AND CHEMICAL PROPERTIES:
Vapor Pressure mm/Hg: 127
Specific Gravity (Water=1): 0.97
Solubility in Water: complete
Freezing Point (OF/OC): not established.
Evaporation Rate (BuAc=1): > 1
Viscosity: Not determined
Boiling Point (OF/OC): 148/64.4
CYTYC P/N 85092-001 Rev. I.
For distribution by Cytyc US
Appearance: clear, thin
Physical State: liquid
Vapor Density (Air=1): 1.1
Percent Volatile by Volume: > 99
pH: Not applicable
Odor: Alcohol type odor
Page 4 of 6
MSDS – CytoLyt ® Solution
10. STABILITY AND REACTIVITY:
General Stability:
Stable
Incompatible Materials And Conditions To Avoid:
Carbon monoxide and carbon dioxide
Hazardous Decomposition Products:
Hazardous Polymerization:
Strong oxidizers. (May ignite product)
Will not occur.
11. TOXICOLOGICAL INFORMATION:
For methanol: Product
not tested as a mixture:
Inhalation LC50 Rat: 64000 ppm/4H
Oral LD50 Rat: 5628 mg/kg
Oral LD50 Mouse: 7300 mg/kg
Dermal LD50 Rabbit: 15800 mg/kg
12. ECOLOGICAL INFORMATION:
Material has very low aquatic toxicity.
LC50 Pimephales promelas (fathead minnows) 29.4 g/l/96 hr, (28-29 days old)
EC50 (30 min) Photobacterium phosphoreum: 51,000-320,000 mg/L:
13. DISPOSAL CONSIDERATION:
RCRA Hazardous Waste if Discarded? Yes.
If so, RCRA ID number: D001, Ignitable waste.
14. TRANSPORTATION INFORMATION: DOT (Department of Transportation)
Proper Shipping Name:
Hazard Class:
Identification Number:
Packing Group:
US DOT
Flammable liquids, n.o.s. (Methanol)
3
UN1993
III
15. REGULATORY INFORMATION:
TSCA (Toxic Substances Control Act):
CERCLA:
RQ for methanol – 5,000 lbs. (2,268 kg) No TPQ established for methanol
SARA 311 Status:
SARA 313:
State Issues:
All ingredients listed on TSCA inventory.
Immediate, fire hazard
Methanol is listed on the 313 Toxic Pollutant reporting list.
Not listed for California Proposition 65
CYTYC P/N 85092-001 Rev. I.
For distribution by Cytyc US
Page 5 of 6
MSDS – CytoLyt ® Solution
Foreign Chemical Inventories:
All ingredients are listed on the chemical inventories of the following countries:
Canada (DSL)
Japan
European Union
Australia
A controlled product. Classification: B2; D1B; D2A
This product has been classified in accordance with hazard criteria of the Controlled
Products Regulations and the MSDS contains all the information required by the Controlled
Products Regulations.
WHMIS Status (Canada):
16. OTHER INFORMATION:
Current Issue Date:
April, 2008
Previous Issue Date:
February, 2005
Changes to MSDS:
Corrected CAS number for Water
Other Information:
None
Information Note: Where no corresponding data was contained in manufacturer’s MSDS, additional research is
required and available upon request. THE INFORMATION RELATES TO THIS SPECIFIC MATERIAL. IT MAY NOT BE
VALID FOR THIS MATERIAL IF USED IN COMBINATION WITH ANY OTHER MATERIALS OR IN ANY PROCESS. IT IS
THE USER’S RESPONSIBILITY TO SATISFY ONESELF AS TO THE SUITABILITY AND COMPLETENESS OF THIS
INFORMATION FOR HIS OR HER OWN PARTICULAR USE.
CYTYC P/N 85092-001 Rev. I.
For distribution by Cytyc US
Page 6 of 6
MSDS – PreservCyt ® Solution
1. CHEMICAL AND COMPANY IDENTIFICATION
PreservCyt® Solution
Product Identification:
Trade Name/Chemical Family/Synonyms:
Product Description:
Methanol-water solution
A methanol based, buffered preservative solution
Product Use:
A preservative solution to support cells during transport and slide preparation.
Manufacturer
Cytyc Corporation
250 Campus Drive
Marlborough, Massachusetts 01752
USA
Telephone: 800-442-9892
EMERGENCY TELEPHONE NUMBERS:
(24 hours a day and 7 days a week)
For Health/Transportation/Chemical Spills
(Multilingual capabilities and free calls accepted)
Continental United States: (800) 424-9300
Outside of continental United States: +(703) 527-3887
2. COMPOSITION/INFORMATION ON INGREDIENTS
Component
Methanol
Water
CAS Registry #
67-56-1
7782-13-5
Wt. %
30 – 60
40 – 70
3. HAZARDS IDENTIFICATION:
EMERGENCY
OVERVIEW:
Material is a clear flammable liquid. Inhalation of vapors may cause nonspecific discomfort
(nausea, weakness), drowsiness with anesthetic effects and possible blindness. Swallowing as
little as 4 ounces (118 ml) may cause blindness and in extreme cases death.
Potential Health Effects.
Inhalation:
May cause depression of central nervous system resulting in nausea, weakness, drowsiness and
possibly blindness.
Eye Contact:
May cause transient irritation.
Skin Contact:
May cause irritation and/or dermatitis. Material may be absorbed through the skin resulting in
effects similar to ingestion or inhalation.
Ingestion:
May cause intoxication, Central nervous system depression, nausea, and dizziness. May damage
liver, kidneys and nervous system. May cause blindness and/or death.
Target Organs:
Liver, kidneys, and central nervous system.
CYTYC P/N 85093-001 Rev. H.
For distribution by Cytyc US
Page 1 of 5
MSDS – PreservCyt ® Solution
Individuals with preexisting diseases of the retina (eyes) or liver may have increased
susceptibility to toxicity at lower levels of successive exposure (repeated exposures).
Medical Conditions
Aggravated by Exposure:
Chronic:
Liquid and vapor can penetrate skin and mucous membranes. May cause chronic liver, kidney or
nervous system disorders.
4. FIRST AID MEASURES:
Inhalation:
Remove patient to fresh air. If symptoms of intoxication or vision problems are apparent, get
immediate medical aid.
Eye Contact:
Immediately flush with clean water for at least 15 minutes. Get medical aid.
Skin Contact:
Remove contaminated clothing and shoes. Flush affected area with copious amounts of water.
If irritation or other symptoms are present, get immediate medical assistance.
Ingestion:
Do Not Induce Vomiting. Give one or two glasses of water and get immediate medical aid.
Notes to Physician:
Treat for CNS depression and possible renal failure.
5. FIRE FIGHTING MEASURES:
Flashpoint and Method:
80ºF
Autoignition Temperature:
725ºF
Flammable Limits:
LEL-6.7 UEL-36
General Hazard:
Flammable material. Heated material may form toxic and/or explosive vapors.
Fire Fighting Instructions:
Wear full turnout gear with self-contained breathing apparatus. If material is not involved
in fire, attempt to cool with water or remove from area. FLAME INVISIBLE IN
DAYLIGHT.
Fire Fighting Equipment:
Wear full turnout gear with self-contained breathing apparatus.
Extinguishing Media:
Foam – Yes
Water – Yes
Hazardous Combustion Products:
Closed cup
(385ºC)
(based on methanol component)
Alcohol Foam – Yes
Other – Water Fog
C02 – Yes
Dry Chemical – Yes
Carbon Monoxide and Carbon Dioxide
Health – 1
Flammability – 3
Reactivity – 0
Special Information – None
NFPA Hazard Rating:
(National Fire Protection
Association)
Special Information:
(26.5ºC)
0=Insignificant
1=Slight
2=Moderate
3=High
4=Extreme
U=Unknown *=No Information
None
CYTYC P/N 85093-001 Rev. H.
For distribution by Cytyc US
Page 2 of 5
MSDS – PreservCyt ® Solution
6. ACCIDENTAL RELEASE MEASURES:
Land Spill
Prevent runoff from entering waterways. Dyke large spills with clay. Absorb small spills with clay or kitty
litter. For spills in excess of 50 gallons, contact licensed HAZWOPER responders.
Water Spill:
Follow local, state and Federal guidelines and regulations.
Follow Local, State, Provincial, and Federal Guidelines for all spills.
7. HANDLING AND STORAGE:
Handling:
KEEP OUT OF THE REACH OF CHILDREN. Wear recommended personal protective equipment and
avoid contact with skin and eyes.
Storage:
Store away from excessive heat and sources of ignition. Keep containers closed and protect from damage.
Storage Temperatures: Without cytologic sample: 59 – 86 ºF (15 – 30ºC)
With cytologic samples, for up to three weeks: 39 – 99 ºF (4 – 37ºC)
8. EXPOSURE CONTROLS / PERSONAL PROTECTIVE EQUIPMENT:
Engineering Controls:
Supply exhaust and/or ventilation to keep vapor levels below threshold limit value.
Respirator:
Where engineering controls are not adequate, use approved NIOSH respirators or supplied
air respirators.
Protective Clothing:
Chemically resistant gloves and eye protection.
Exposure Limits for Ingredients:
Ingredient
OSHA PEL
Methanol
200 ppm – TWA
TWA – 8 hr
STEL – 15 minute
ACGIH TLV®
200 ppm – TWA
250 ppm – STEL
Skin
Canada – Alberta, British Columbia, New Canada – Saskatchewan
Brunswick, Manitoba, Ontario,
Quebec, and Yukon
200 ppm – TWA
262 mg/m3 TWA
328 mg/m3 STEL
250 ppm – STEL
Skin
9. PHYSICAL AND CHEMICAL PROPERTIES:
Vapor Pressure mm/Hg: 127
Specific Gravity (Water=1): 0.92
Solubility in Water: complete
Freezing Point (OF/OC): not established.
Evaporation Rate (BuAc=1): > 1
Viscosity: Not determined
Boiling Point (OF/OC): 148/64.5
CYTYC P/N 85093-001 Rev. H.
For distribution by Cytyc US
Appearance: clear, thin
Physical State: liquid
Vapor Density (Air=1): 1.1
Percent Volatile by Volume: > 99
pH: Not applicable
Odor: Alcohol type odor
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MSDS – PreservCyt ® Solution
10. STABILITY AND REACTIVITY:
General Stability:
Stable
Incompatible Materials And Conditions To Avoid:
Hazardous Decomposition Products:
Hazardous Polymerization:
Strong oxidizers. (May ignite product)
Carbon monoxide and carbon dioxide
Will not occur.
11. TOXICOLOGICAL INFORMATION:
For methanol: Product
not tested as a mixture:
Inhalation LC50 Rat: 64000 ppm/4H
Oral LD50 Rat: 5628 mg/kg
Oral LD50 Mouse: 7300 mg/kg
Dermal LD50 Rabbit: 15800 mg/kg
12. ECOLOGICAL INFORMATION:
Material has very low aquatic toxicity.
LC50 Pimephales promelas (fathead minnows) 29.4 g/l/96 hr, (28-29 days old)
EC50 (30 min) Photobacterium phosphoreum: 51,000-320,000 mg/L:
13. DISPOSAL CONSIDERATION:
RCRA Hazardous Waste if Discarded? Yes.
If so, RCRA ID number: D001, Ignitable waste.
14. TRANSPORTATION INFORMATION: DOT (Department of Transportation)
Proper Shipping Name:
Hazard Class:
Identification Number:
Packing Group:
CYTYC P/N 85093-001 Rev. H.
For distribution by Cytyc US
US DOT
Flammable liquids, n.o.s. (Methanol)
3
UN1993
III
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MSDS – PreservCyt ® Solution
15. REGULATORY INFORMATION:
TSCA (Toxic Substances Control Act):
CERCLA:
RQ for methanol – 5,000 lbs. (2,268 kg) No TPQ established for methanol
SARA 311 Status:
SARA 313:
State Issues:
All ingredients listed on TSCA inventory.
Immediate, fire hazard
Methanol is listed on the 313 Toxic Pollutant reporting list.
Not listed for California Proposition 65
Foreign Chemical Inventories:
All ingredients are listed on the chemical inventories of the following countries:
Canada (DSL)
Japan
European Union
Australia
A controlled product. Classification: B2; D1B; D2A
This product has been classified in accordance with hazard criteria of the Controlled
Products Regulations and the MSDS contains all the information required by the Controlled
Products Regulations.
WHMIS Status (Canada):
16. OTHER INFORMATION:
Current Issue Date:
February, 2005
Previous Issue Date:
July, 2002
Changes to MSDS:
New format and revision of text to improve clarity. Addition of non-US exposure values.
Other Information:
None
Information Note: Where no corresponding data was contained in manufacturer’s MSDS, additional research is
required and available upon request. THE INFORMATION RELATES TO THIS SPECIFIC MATERIAL. IT MAY NOT BE
VALID FOR THIS MATERIAL IF USED IN COMBINATION WITH ANY OTHER MATERIALS OR IN ANY PROCESS. IT IS
THE USER’S RESPONSIBILITY TO SATISFY ONESELF AS TO THE SUITABILITY AND COMPLETENESS OF THIS
INFORMATION FOR HIS OR HER OWN PARTICULAR USE.
CYTYC P/N 85093-001 Rev. H.
For distribution by Cytyc US
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