Nipple-Areolar Complex

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Nipple-Areolar Complex
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EDUCATION EXHIBIT
509
Nipple-Areolar Complex: Normal Anatomy
and Benign and Malignant Processes1
Online-Only
CME
See www.rsna
.org/education
/rg_cme.html
LEARNING
OBJECTIVES
After reading this
article and taking
the test, the reader
will be able to:
■■Describe
the normal anatomic variants and abnormal
processes that may
affect the nippleareolar complex.
■■Recognize
abnormal imaging features in the nippleareolar complex.
■■Describe
the
clinical and imaging
findings of Paget
disease of the nipple
and the most appropriate methods
for managing various phases of the
disease.
Brandi T. Nicholson, MD • Jennifer A. Harvey, MD • Michael A. Cohen, MD
The nipple-areolar complex may be affected by many normal variations in embryologic development and breast maturation as well as
by abnormal processes of a benign or malignant nature. Benign processes that may affect the nipple-areolar complex include eczema,
duct ectasia, periductal mastitis, adenomas, papillomas, leiomyomas,
and abscesses; malignant processes include Paget disease, lymphoma, and invasive and noninvasive breast cancers. Radiologists should
be aware of the best methods for evaluating each of these entities:
Many disorders of the nipple-areolar complex are unique or differ in
important ways from those that occur elsewhere in the breast, and
they require a diagnostically specific imaging evaluation. Patients
may present with benign developmental variations; inversion, retraction, or enlargement of the nipple, which may have either a benign
or a malignant cause; a palpable mass; nipple discharge; skin changes
in and around the nipple; infection with resultant nipple changes or
a subareolar mass; or abnormal findings at routine mammographic
screening. Further diagnostic imaging may include repeat mammography, breast ultrasonography, galactography, and magnetic resonance imaging. When skin changes are present, a clinical evaluation
by the patient’s primary care physician, dermatologist, or surgeon
should be part of the diagnostic work-up.
©
RSNA, 2009 • radiographics.rsnajnls.org
TEACHING
POINTS
See last page
Abbreviation: DCIS = ductal carcinoma in situ
RadioGraphics 2009; 29:509–523 • Published online 10.1148/rg.292085128 • Content Codes:
1
From the Department of Radiology, University of Virginia, 1215 Lee St, Charlottesville, VA 22908. Presented as an education exhibit at the 2007
RSNA Annual Meeting. Received May 29, 2008; revision requested July 1 and received August 4; accepted August 19. J.A.H. is a researcher with
General Electric, Wyeth, and NV Organon; all other authors have no financial relationships to disclose. Address correspondence to B.T.N. (e-mail:
bte6v@virginia.edu).
©
RSNA, 2009
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Introduction
The nipple-areolar complex may be affected by a
broad array of disease processes, many of which
have similar appearances; thus, the precise application of clinical and diagnostic skills is necessary
for their differentiation and diagnosis. The detection of disorders of the nipple-areolar region may
be challenging because of the complex anatomy
of this region. A thorough understanding of anatomic variants, benign and pathologic processes,
and the imaging features specific to each is the
necessary basis for a comprehensive and appropriate imaging assessment, diagnosis, and, if
necessary, intervention. In this article, we review
normal anatomic variants and benign and malignant processes that may affect the nipple-areolar
complex and describe the imaging techniques
that are most useful for evaluating this region.
Normal Anatomy
Embryologic Development
During the 6th week of gestation, paired mammary ridges or milk lines develop on the ventral
surface of the embryo, extending from the axilla
to the medial thigh. In large part, these milk
lines later atrophy; only the part in the pectoral
region, where the breasts will develop, remains
(1). The development of the nipple-areolar complex begins in the 12th–16th weeks of gestation,
with the differentiation of mesenchymal cells
into smooth muscle components. This event is
quickly followed by the development of special
apocrine glands into the Montgomery glands. In
the first stage of glandular development, between
eight and 12 mammary ducts form. These ducts
are associated with sebaceous glands near the
epidermis. Differentiation of the breast parenchyma and development and pigmentation of the
nipple-areolar complex begin around the 32nd
week and continue to the 40th week (2). This
developmental process is the same for both males
and females.
Breast Maturation
During puberty, the breast mound increases
in size. Subsequent enlargement and outward
growth of the areola result in a secondary
mound (1). Eventually, the areola subsides to
Figure 1. Normal anatomy of the nipple-areolar
complex.
the level of the surrounding breast tissue, leaving a single breast mound (1). At full development, the nipple-areolar complex overlies the
area between the 2nd and 6th ribs, with a location at the level of the 4th intercostal space being typical for a nonpendulous breast. The adult
breast consists of approximately 15–20 segments
demarcated by mammary ducts that converge
at the nipple in a radial arrangement (Fig 1).
Like the number of segments, the number of
mammary ducts may vary (3). The collecting
ducts that drain each segment, which typically
measure about 2 mm in diameter, coalesce in
the subareolar region into lactiferous sinuses
approximately 5–8 mm in diameter (Fig 2).
Women occasionally detect a normal lactiferous
sinus as a palpable finding at self-examination.
In the typical breast, there are 9–20 orifices that
drain the segments at the nipple (3,4).
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Variant Anatomy
Figure 2. Palpable lactiferous sinus. Ultrasonographic (US) image of the subareolar region in a
woman with a palpable mass depicts a normal lactiferous sinus (arrow).
Figure 3. Mammograms show bilateral tuberous
breasts with herniation of breast parenchyma through
the nipple-areolar complex.
Nipple-Areolar Complex
The nipple-areolar complex contains the Montgomery glands, large intermediate-stage sebaceous glands that are embryologically transitional
between sweat glands and mammary glands and
are capable of secreting milk (3). The Montgomery glands open at the Morgagni tubercles, which
are small (1–2-mm-diameter) raised papules on
the areola (Fig 1) (5). The nipple-areolar complex also contains many sensory nerve endings,
smooth muscle, and an abundant lymphatic
system called the subareolar or Sappey plexus.
Because the skin of the nipple is continuous with
the epithelium of the ducts, cancer of the ducts
may spread to the nipple (3).
There are many possible variants from normal
breast development. Knowledge and recognition
of these help physicians avoid unnecessary imaging evaluations of benign conditions. The most
common abnormal variant, polythelia, occurs
when involution of the milk line is incomplete and
an accessory nipple or nipples form. Polymastia
(formation of an accessory true mammary gland)
also may occur when involution of the milk line is
incomplete, but it is rare. Accessory nipples and
breast tissue most commonly develop in the axilla
or inframammary fold, but they may occur anywhere along the embryologic milk line, from the
axilla to the groin. Because they are pigmented,
accessory nipples may be mistaken for moles.
Hypoplasia (underdevelopment of the breast)
and amazia (lack of breast tissue, but with the
presence of a nipple) are also rare and typically
do not affect the appearance of the nipple-areolar
complex. Amazia is usually iatrogenic, resulting from surgery or irradiation, whereas amastia
(lack of both the breast tissue and the nipple) is
congenital. When amastia occurs unilaterally, it
is associated with absence of the pectoral muscle;
when it occurs bilaterally, it is associated with
various other birth defects (6). If breast development is interrupted at the stage of the secondary
mound, the areola will have an appearance that
is characteristic of a tuberous breast. Tuberous
breasts are defined by reduced parenchymal
volume and by herniation of breast parenchyma
through the nipple-areolar complex (Fig 3) (2,7).
Nipple Retraction or Inversion
The terms retraction and inversion often are used
interchangeably, but such usage is inexact. Retraction is properly applied when only a slitlike
area is pulled inward (Fig 4), whereas inversion
applies to cases in which the entire nipple is
pulled inward—occasionally, far enough to lie
below the surface of the breast (Figs 5, 6) (8).
Both retraction and inversion may be either
congenital or acquired and either unilateral or
bilateral. Bilateral and slowly progressive or
long-standing nipple retraction is likely benign
and may be a normal variant. A woman with an
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Figure 4. (a) Photograph of a woman’s breast shows slitlike retraction of the nipple, a finding that is typically
benign and often bilateral. (b, c) Spot compression mammogram (b) and sagittal contrast-enhanced T1-weighted
MR image (c) obtained in another woman show slitlike retraction of the nipple in profile. No mass or other possible
cause of retraction is visible. The clip in b is from a previous core-needle biopsy. In c, the thin (1–2-mm) dermis of
the nipple shows a normal enhancement pattern.
Figure 5. Benign nipple inversion. Sagittal (a) and axial (b) contrast-enhanced T1-weighted
MR images show an inverted enhancing nipple that mimics a mass (arrowheads). This finding was
bilateral and symmetric. The contralateral inverted nipple, which is not visible in b, was depicted
in a different imaging section.
acquired unilateral nipple inversion may have an
underlying malignancy or inflammatory condition and should undergo evaluation with mammography and possibly US or magnetic resonance (MR) imaging (Fig 6). The differential diagnosis in a case of acquired nipple retraction or
inversion includes inflammatory conditions such
as duct ectasia (common), periductal mastitis,
and tuberculosis, as well as malignancy (8). Central, symmetric, slitlike retraction usually indicates a benign process (Fig 4), whereas inversion
of the whole nipple with distortion of the areola
is typically a result of malignancy (Fig 6) (8).
Imaging Caveats
The nipple may be mistaken for a mass both at
mammography and at MR imaging. To prevent
such an event, the nipple should be positioned in
profile on at least one mammographic view (9).
If the source of an apparent mass is questionable
Teaching
Point
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Figure 6. Unilateral nipple inversion secondary to an underlying malignant mass. This case highlights
the importance of imaging the nipple in profile. (a, b) Standard mammographic views. The invasive
ductal carcinoma that is visible on the craniocaudal projection (arrow in a) is not well depicted on the
mediolateral oblique view (b), probably because the latter does not show the nipple in profile. The subareolar region may be difficult to evaluate even when the proper technique is used. (c) US image helps
confirm the presence of a retroareolar mass (arrowheads).
Figure 7. (a) Craniocaudal and mediolateral mammograms show an apparent mass (arrows), a spurious finding
caused by failure to position the breast with the nipple in profile. (b) Repeat mammograms obtained with a BB positioned on the nipple and with the nipple in profile show no mass.
Teaching
Point
and the nipple is not visible in profile, doubts
may be laid to rest by placing a BB on the nipple
and repeating the mammographic acquisition
with the nipple in profile (Fig 7). Keeping the
nipple in profile and applying appropriate imaging techniques also helps improve the detection
of retroareolar masses (Fig 6). The retroareolar
region is a challenging location in which to detect
a mass, and oblique positioning of the nipple or
underexposure of the image may obscure a significant finding (10). Clinical examination is more
sensitive than mammography for the detection of
subareolar or central (within 2 cm of the nipple)
cancers (11). Approximately 8% of breast cancers
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Figure 8. Sagittal
contrast-enhanced
T1-weighted MR
images show normal variations in
the most common
pattern of nipple
enhancement—a
thin rim of increased
signal intensity—in
breasts without (a)
and with (b) slight
nipple retraction.
The normal nipple
also may demonstrate no significant
enhancement.
Figure 9. (a) Mammogram shows a skin
tag on the areola, a
finding that mimics
a mass. (b) Physical
examination and repeat mammography
with a BB placed
on the skin lesion
helped confirm the
nature of the finding.
arise in the subareolar region (12), and these cancers are usually palpable (10). If a patient presents with a palpable mass behind the nipple, spot
compression views may better demonstrate the
mass than routine mammographic images.
During US evaluation of a subareolar abnormality, a standoff pad moves the finding into the
focal zone of the ultrasound beam (about 1.5 cm)
and improves the detectability of a mass (13). On
US images, the nipple often is depicted with posterior acoustic shadowing, which likely is due to
the fibrous composition of nipple tissue and the
confluence of multiple structures with interfaces.
The use of a standoff pad helps remove shadowing caused by air trapped in the crevices within
the raised nipple. The use of copious amounts
of US gel with various compression techniques,
described by Stavros (13), also may help improve
the detection of clinically significant lesions located near or in the nipple.
The normal nipple may have various imaging
appearances on MR images obtained after the
administration of contrast material (Fig 8). Normal nipples typically are surrounded by a smooth
thin rim of enhancement and appear symmetric
bilaterally (14). This characteristic appearance
is maintained even if a nipple is retracted or inverted. However, the area of enhancement sur-
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Figure 10. Mammograms show typical benign nipple calcifications (arrow), which are round and either homogeneous (a) or lucent centered (b).
Figure 11. Mammogram shows benign skin calcifications in scar tissue in the areola of a woman with
a history of reduction mammoplasty.
rounding an inverted nipple in the subareolar position may cause it to be mistaken for a mass (Fig
5). Comparison of the appearance of both breasts
and correlation of the areas of enhancement in
two intersecting mammographic planes may help
confirm that the finding is an inverted nipple
and not a clinically significant lesion. The normal
nipple also may not enhance in some patients.
Skin lesions on the areola also may resemble
masses. Identifying a superficial skin lesion or
skin tag with a metallic marker before performing
mammography may help clarify the nature of an
apparent mass and help avoid unnecessary further
imaging and other diagnostic evaluations (Fig 9).
Calcifications may develop in the nippleareolar complex in some patients and typically
are benign (Fig 10) (15,16). Calcifications may
occur in the skin of the areola, within the Montgomery glands, within hair follicles, in association with a mass, or in the context of Paget disease. Calcifications in the skin of the areola may
be secondary to surgery such as reduction mammoplasty (Fig 11) but also may occur in patients
without a history of such surgery. Occurrences
of calcified cutaneous horns, conical projections
of keratin above the skin surface in the nippleareolar complex, also have been described (16).
Cutaneous horns are typically asymptomatic
and benign but also have been associated with
malignant lesions, including Paget disease and
squamous cell carcinoma (17,18).
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Figure 12. Photograph shows
bilateral symmetric eczema of the
nipple and areola, a benign process
characterized by erythema, scaling,
and crusting.
Skin Changes
Both benign and malignant processes may produce visible changes in the skin of the nipple,
including erythema, scaling, crusting, fissures,
vesicles, erosions, lichenification, or some combination of these. These changes may be accompanied by pain or itching (19). Correct diagnosis
of the underlying pathologic process is important
because of the possibility of a breast malignancy
(20). A negative result at cytologic analysis of
an associated discharge may be inaccurate (21),
and the imaging appearance may be normal. The
clinical history may be helpful, but histologic
analysis of a biopsy specimen often is necessary
for accurate diagnosis.
Benign Processes
Eczema of the nipple-areolar complex typically
occurs bilaterally (Fig 12) and may be associated
with systemic symptoms of atopic dermatitis,
including (but not limited to) flexural dermatitis
(22). Eczema is responsive to topical application
of a moderate-dose steroid cream. However, if
the symptoms do not improve, a biopsy may be
necessary to exclude Paget disease of the nipple,
which may have a similar appearance.
Psoriasis also may cause nipple changes, including excoriation and ulceration (23). A complete clinical history may be helpful for differential diagnosis, as patients may have other manifestations of disease. Other benign processes that
occasionally cause similar changes in the nipple
include allergic contact dermatitis, irritant dermatitis (so-called jogger’s nipple), lichen simplex
chronicus, and Candida infection (which typically
occurs in lactating women) (24).
In addition, two rare conditions of the nippleareolar complex may be seen: nevoid hyperkera-
tosis, a benign idiopathic condition that is characterized by slowly growing verrucous thickening
and hyperpigmentation of the nipple, areola, or
both (25); and periareolar fistula, an extraintestinal cutaneous manifestation of Crohn disease
(26). The latter diagnosis should be considered
when a lesion initially thought to be a breast abscess is not controlled with antibiotics.
Malignant Processes
Paget disease of the nipple-areolar complex is
characterized by the presence of neoplastic cells
in the epidermis. It is most often associated with
underlying ductal carcinoma in situ (DCIS) and
rarely with invasive ductal cancer (27). Paget
disease is typically suspected on the basis of specific clinical manifestations, particularly if the
skin changes are unilateral and associated with a
breast mass, breast calcifications, or a nipple
discharge. The gamut of skin changes may range
from mild to severe, with a variety of appearances including nipple erythema, scaliness, erosion, ulceration, and fissures (Fig 13). When an
underlying invasive breast cancer is present, the
physical manifestations may include skin retraction, skin thickening, or a palpable mass. When
these signs are evident and Paget disease is suspected, imaging should be performed to detect
the underlying carcinoma.
A mammogram may depict a mass or calcification representative of invasive cancer or DCIS,
respectively. However, mammographic findings
in some patients with breast cancer and Paget
disease are normal (28). In one study, breast
cancer was occult at mammography in 15% of
52 patients with Paget disease and at both mammography and US in 13% of those patients (28).
US depicts changes within the nipple or immediately deep to it in a few patients with Paget
disease; however, the findings are nonspecific and
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Point
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Figure 13. Photographs show variations in the appearance of Paget disease of the nipple, from
erythematous changes (a, b) to the more typical eczematoid changes (c–f), which range from
mild (c) to severe (f).
Teaching
Point
resemble those in cases of infection. US images
may reveal parenchymal heterogeneousness, hypoechoic areas, discrete masses, skin thickening,
or dilated ducts (28). In patients in whom the
mammographic findings are normal or the extent
of disease is uncertain, MR imaging may show
abnormal nipple enhancement, thickening of the
nipple-areolar complex, an associated enhancing DCIS or invasive tumor, or a combination of
these (29–31).
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Figure 14. Benign mass of the nipple-areolar
complex. Mammogram (a) and US image (b)
show an ovoid circumscribed mass (arrowheads)
that appears isodense in a and hypoechoic in b.
Analysis of a biopsy specimen showed it to be a
fibroadenoma.
Bowen disease (squamous cell carcinoma in
situ) is an additional possibility when a patient
presents with an itchy and scaly nipple. However,
squamous cell carcinoma is only rarely found in
the nipple-areolar complex. Bowen disease cannot be clinically differentiated from Paget disease,
and a biopsy is necessary for diagnosis (32).
Masses
Masses of the nipple and the underlying subareolar ducts are most commonly benign (Figs
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Figure 15. Benign mass associated with a unilateral spontaneous bloody discharge from the
nipple. (a) Galactogram shows a filling defect
(arrow) in the nipple-areolar complex. (b) US
image shows a complex mass in the same location (area between the cursors). The mass was
diagnosed as a papilloma at surgical excision.
14, 15). The differential diagnosis of such masses
includes papilloma, adenoma, fibroadenoma,
and complicated cyst (fibrocystic changes). Patients may present with a palpable lump, visible
infection, or nipple discharge, or a mass may be
clinically occult and detected only at screening.
When clinical symptoms are present and findings
at routine mammography are normal, it may be
necessary to perform spot compression mammography, US, galactography, or MR imaging to
localize and diagnose the cause of symptoms. The
lesions may enhance and may be associated with
an abnormal dilated and fluid-filled duct on MR
images (Figs 16, 17).
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Figures 16, 17. (16) Benign nipple mass in a patient with a breast malignancy. (a) Sagittal
contrast-enhanced T1-weighted MR image shows an enhanced margin around the lumpectomy
site (arrow) and a peripherally enhancing mass in the nipple (arrowheads). (b) US image depicts
a complex mass (arrowheads) that subsequently was identified as a papilloma. (17) Intraductal
mass associated with a unilateral, spontaneous, bloody nipple discharge. The mass, which was not
evident at routine mammography, was well depicted at galactography as a filling defect (arrowhead in a); at US as an echogenic lesion within the duct (arrow in b); and at MR imaging as an
enhancing region with high signal intensity on the contrast-enhanced T1-weighted subtraction image (arrowhead in c) and a hypointense lesion within the high-signal-intensity dilated fluid-filled
duct on the T2-weighted image (arrowhead in d). The mass proved to be a papilloma.
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Benign Processes
Teaching
Point
Benign lesions include cysts, fibroadenomas, adenomas, papillomas (Figs 15–17), galactoceles,
abscesses (Fig 18), leiomyomas, and, more rarely,
nodular mucinosis (33) and spindle cell proliferation like that seen in fibrous histiocytoma (34). It
may be difficult to differentiate the most common
of these entities from one another, as their imaging features are similar and nonspecific; therefore,
a biopsy may be necessary for diagnosis. The
clinical history may be helpful: Papillomas may
manifest with a nipple discharge (35); abscesses
may be associated with redness, swelling, and
pain; and fibrous histiocytoma–like spindle cell
proliferation may occur after nipple piercing (36).
Morphologic features also are helpful for narrowing the differential diagnosis of a mass in the nipple-areolar complex: Papillomas, adenomas, and
leiomyomas are typically oval and circumscribed,
whereas abscesses and fibrous lesions are more
commonly ill defined.
Abscesses may have an appearance that
arouses suspicion, with an irregular shape, ill-defined or spiculated margins, high density at mammography, and a central region of hypoechogenicity with a thick echogenic rim at US (Fig 18).
The imaging features of an abscess are difficult
to differentiate from those of a breast carcinoma.
The differential diagnosis of nonpuerperal breast
abscesses includes chronic recurrent subareolar
breast abscess, inflammatory breast cancer, cystic breast disease, duct ectasia, and fat necrosis
(37). The clinical manifestation and past medical history may be helpful, but symptoms may
be minimal. Patients who are presumed to have
an infection should undergo follow-up imaging
evaluations to exclude a malignancy until the
appearance of the region returns to normal. It is
noteworthy that lymph nodes may be enlarged in
the presence of either malignancy or infection.
The Montgomery glands, which are located
in the areola, may become inflamed and congested, conditions that may cause the secretion
of glandular fluid at the areolar surface (38).
The discharge, which is a milky white color, may
Figure 18. Retroareolar abscess. Mammogram (a) and US image (b) show a high-density,
ill-defined heterogeneous mass with an irregular
margin.
be mistaken for a sign of malignancy. When the
gland is partially blocked, a palpable mass may
develop. Imaging then shows a cyst beneath the
area of discharge on the areola (Figs 19, 20).
When glandular congestion and blockage are
caused by infection, the condition may be painful (Fig 21). A discharge that is associated with a
palpable lump in a Montgomery gland usually resolves spontaneously. Treatment, whether surgical
or medical, should be reserved for cases in which
the discharge persists (38).
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Figures 19, 20. (19) Milk-white discharge and palpable mass associated with Montgomery gland
blockage. (a) Photograph shows a drop of whitish discharge (arrow) on the areola. (b) US image
obtained with a standoff pad demonstrates an oval, circumscribed, nearly anechoic areolar cyst (arrowhead). (20) Montgomery gland blockage caused by infection. (a) Photograph shows an areolar
mass (arrowheads) that was palpable and tender at physical examination. (b) Transverse US image
demonstrates an oval, hypoechoic mass in the areola, in the expected location of a Montgomery
gland (arrowheads). The findings were suggestive of glandular blockage, infection, or both. After a
course of treatment with antibiotic and antifungal medications, the symptoms resolved.
Figure 21. Nipple abscess. (a) Photograph shows a reddened and swollen nipple mass (arrow)
that was painful at palpation. (b) US image demonstrates a hypoechoic mass (arrows) with posterior shadowing, a finding indicative of an abscess. The mass resolved after treatment with antibiotic medication.
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Figure 22. Invasive ductal carcinoma.
Mammogram (a), US image (b), and axial
contrast-enhanced T1-weighted subtraction
MR image (c) demonstrate an ill-defined
retroareolar mass with an irregular margin, a
finding highly suggestive of a malignancy.
Malignant Processes
Both invasive and noninvasive breast cancers may
originate immediately deep to the nipple and
extend into it (Fig 22). However, the typical malignant mass of the nipple-areolar complex is invasive ductal carcinoma, the most common type
of breast cancer (16). Since malignant masses
are indistinguishable from abscesses at imaging,
careful attention should be given to the clinical
history. If there are no obvious signs of infection,
a biopsy should be performed to determine the
origin of a subareolar mass.
Conclusions
The nipple-areolar complex may be affected by
various diseases, many of which are unique to
this region of the breast. Clinical history and
physical examination are helpful for diagnosis
in many cases. Additional imaging evaluations
beyond standard dual-view mammography may
be necessary to visualize or exclude an underlying mass or other abnormality. When routine
mammographic findings are negative but clinical
findings arouse suspicion about the presence of a
malignancy, US and MR imaging may facilitate
the diagnosis.
Acknowledgments: The authors thank Kenneth
Greer, MD, and Barbara Wilson, MD, for contributing
the dermatologic photographs.
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This article meets the criteria for 1.0 AMA PRA Category 1 Credit TM. To obtain credit, see www.rsna.org/education
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RG
Volume 29 • Number 2 • March-April 2009
Nicholson et al
Nipple-Areolar Complex: Normal Anatomy and Benign and
Malignant Processes
Brandi T. Nicholson, MD, et al
RadioGraphics 2009; 29:509–523 • Published online 10.1148/rg.292085128 • Content Codes:
Page 512
Central, symmetric, slitlike retraction usually indicates a benign process, whereas inversion of the
whole nipple with distortion of the areola is typically a result of malignancy.
Page 513
The retroareolar region is a challenging location in which to detect a mass, and oblique positioning of
the nipple or underexposure of the image may obscure a significant finding.
Page 516
Paget disease is typically suspected on the basis of specific clinical manifestations, particularly if the
skin changes are unilateral and associated with a breast mass, breast calcifications, or a nipple
discharge.
Page 51777
In patients in whom the mammographic findings are normal or the extent of disease is uncertain, MR
imaging may show abnormal nipple enhancement, thickening of the nipple-areolar complex, an
associated enhancing DCIS or invasive tumor, or a combination of these.
Page 520
The imaging features of an abscess are difficult to differentiate from those of a breast carcinoma.