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Pages 5 - Cornea Research Foundation of America
Annual Report Fiscal Year Ending June 30, 2011 www.cornea.org Table of Contents Page 3 - 4 Message from Marianne Price, PhD Executive Director & Francis W. Price, Jr., MD, Founder and Chairman Pages 5 - 6 Treasurer’s Report Page 7 - 12 Donor Acknowledgement Page 13 - 14 Featured Research Page 15 - 16 Award Winning Research Page 17 - 18 Special Events Page 19 - 22 Publications and Meetings OUR MISSION: TO B E A WO R L D - CLASS RESEARCH A N D E D U C AT I O N A L O R G A N I Z AT I O N , D E D I C AT E D TO T H E P R E S E RVAT I O N About this Report The achievements featured within this report, along with the goals outlined for the future growth showcase the dynamic research strategies underway at the Foundation. We work to develop and refine cutting-edge procedures and techniques to restore sight and faith for individuals around the world. A N D R E S TO R AT I O N OF VISION. Your donations help restore sight. About the Foundation As a 501(c)3 not for profit founded in 1988, the Cornea Research Foundation of America, is an award winning, internationally recognized research and educational organization, dedicated to the preservation and restoration of vision and known for conducting clinical studies to evaluate new drugs, lasers, devices and treatments. We measure our success based on four pillars: Research, Innovation, Service to Humanity, and Education, summarized in the acronym RISE. Our goal is to continually find new and better ways to give people back the use of their eyes so they can attend school, make a living, and support their family. We share our findings through frequent presentations, publications and medical educa- W W W. C O R N E A . O R G tion courses so that patients throughout the world can benefit from our findings. A Message from the Executive Director What an exciting year! Our work has attracted international recognition - we were invited to share our cornea transplant findings at major eye meetings in Europe, Asia and South America. We were fortunate to have two gifted cornea specialists, from leading eye centers in Brazil and Singapore, join us for one-year research fellowships. Dr. Guerra and Dr. Anshu were incredibly productive and their work on improved cornea transplant techniques resulted in 12 publications in leading eye journals. In addition, we were honored to receive the prestigious Santa Caterina d’Oro award for excellence in medical research, at a lovely ceremony held annually in the historic town of Siena, Italy. We envision a future where corneal problems are detected and treated early, before leading to serious vision loss. We are making steady progress toward this goal by identifying the underlying genetic causes of Fuchs dystrophy. This work should ultimately lead to early detection and innovative treatments. In addition, we are having good results with an investigational corneal strengthening treatment that can help preserve the vision of teenagers and young adults who have a condition known as keratoconus. Collaborating with other centers around the country, we detected a surprisingly high incidence of antibiotic-resistant bacteria on the surface of the eye and eyelids of patients scheduled for cataract surgery, clearly demonstrating the need for new and improved antibiotics. To help address this need, we are among a select group of centers pioneering the use of an innovative light treatment to kill organisms that cause eye infections. Some of the most serious eye infections occur in young people who wear contact lenses for extended periods of time, and we are finding this treatment to be very helpful for these young folks. We are proud that Working Vision, the fledgling organization we helped nurture the past several years, has recently taken flight and achieved independent non-profit status. Working Vision is the brainchild of Grant Moore, one of our former summer interns who later spent a summer working at a large eye clinic in Kathmandu, Nepal. While there, he was amazed at the number of patients with serious eye injuries that could have been prevented with proper eyewear. So he initiated a program to collect new and gently used safety eyewear in the USA for distribution in Nepal. Working Vision continues to expand in scope and now provides eye safety programs and vision screenings, in addition to distributing safety eyewear. It’s been an honor for us to support these efforts. Helping people regain vision and resume daily activities is an immensely rewarding endeavor. We appreciate the generous support of our donors and the dedication of our staff that makes this possible. Sincerely, Marianne O. Price, Ph.D. Executive Director This last year represented the 22nd year of the Cornea Research Foundation of America, and it was a year of major achievements. Achievements ranged from discovering that a new ultra-thin corneal transplant has 15 to 20 times less risk of developing a rejection episode than earlier types of corneal transplants, to for the first time, describing the proteins in the anterior part of the eye which may be responsible for causing corneas to turn cloudy after glaucoma surgery. We also were able to accumulate more revenue through donations and study-related income to fund our research activities. Since our foundation does not receive funding from the federal government, these contributions are essential for what we do. An often used saying is that with great gifts come great responsibility, and we take our gifts very seriously. The Foundation is embarking on an ambitious research path that has the potential to dramatically change the way we approach vision correction, transplant treatments, and management of those with complicated glaucoma problems. Because of our ongoing corneal transplant data base, the largest one in the Western Hemisphere, we can compare rejection rates between standard full thickness corneal transplants, DSEK transplants, and the new ultra-thin DMEK grafts. We recently found that the chance of having a rejection episode is15 times less for DMEK than DSEK, and 20 less in comparison to a full thickness transplant. Topical corticosteroids, the antirejection drops we use after corneal transplants cause about 1/3 of patients to develop glaucoma in the first year after receiving a transplant. Since DMEK appears to have a significantly reduced rate of rejection, the Foundation is sponsoring a multi-center, international study to evaluate two different corticosteroid dosing regimens to see if we can reduce the rate of developing glaucoma without increasing the rejection rate. No one has ever done a prospective study evaluating different topical corticosteroid dosing regimens for corneal transplants even though it is the most common tissue transplant in the U.S. for over 60 years. And like all medications used with corneal transplants, it is an ―off label‖ use of the drops – so the FDA told us we had to file for investigational drug exemption (IDE) study with them – which we have. The Foundation is sponsoring a prospective, 3-year study with both national and international study sites evaluating patient satisfaction and visual difficulties with different vision correction methods. Other than glasses, contact lenses and Lasik are the two most common ways to correct vision. No one has ever taken on a study to evaluate how satisfied patients are with these means of visual correction and what their visual difficulties might be. Industry is reticent to do this I suspect due to liability and regulatory concerns. The government, well, they seem preoccupied with other things right now. From a public health standpoint and planning for future correction of vision, this study is very important and should lead to identification of areas of improvement for both contact lenses and Lasik. We hope to enroll between 2 and 5 thousand patients. Funding will determine the number we can enroll. Finally, our third major area will be looking at fluid taken from the front part of the eye to help determine why some patients, like those with glaucoma filters, have damage to the endothelial cells on the inside of the cornea and to see what is happening in eyes with rejection episodes. Our hope is to develop focused, more effective treatments for both of these problems Each of these three studies are major undertakings, and each has the potential to make landmark changes in the way we treat diseases of the eye. Your gifts and support make all of this possible. Thank you! Francis W. Price, Jr., MD Founder and Chairman A Message from the Chairman Treasurer’s Report by Walter C. Gross, Jr. The Cornea Research Foundation of America had a great year. Total revenue for the fiscal year ended June 30, 2011 was $742,510. In comparison to 2010, we saw an increase due to substantial growth in clinical study earned income. Our In-Kind Contributions were also much higher than in years’ past, thanks to services generously donated by many doctors. We are careful with our expenses, and for that reason 89% of our operating budget directly funds research and education programs. Revenue Expenses 1% Guidestar and the Better Business Bureau’s Wise Giving Alliance have certified that the Foundation meets their Charity Accountability Standards. 5% 5% 27% 24% 6% Contributions Research and Education Service Related Income Development In-Kind Contributions Special Events Administrative Interest and Other Walter C. Gross, Jr. Treasurer 43% 89% We thank our generous supporters. John C. and Bette B. Miller Charitable Foundation Marilou L. Dickey Anonymous Jack and Jane Donadee Wayne and Linda Adams Essilor of America, Inc. Rider Insurance Agency Fairfield Engineered Drive Solutions Akers Tire Company, Inc. Michael and Jeanette Garvey Mohammed Al Marar Chloe Alyce Hughes Applied Engineering Services Inc. Audrey Ingram Joseph and Barbara Barker Joe Kack Canfield Lions Club, Inc. Richard and Barbara Justice Ryan Cole Harold Laut Melvin and Frances Davis M&I Bank Bud DeCleene, OD Marco Frank and Beverly Deramo Carl Zeiss Meditec, Inc. John Devine Oasis Medical, Inc. George and Alpha Dinkel Craig Olson EAH-JJK Properties, LLC LensTech Optical, Inc. Philip and Patricia Gibson Jeffrey and Laurie Potrzebowski Robert and Cynthia Grimm Marijke Raju Stephen J. Hackman Cheryl Sokoll Jeffrey King STAAR Surgical Company Richard King Partners Schwarz Partners, LP Lewis Liggett Stanley and Barbara Schwartz Gifts from $500 to $999 Holly and Dennis Lewton Shirley and Erwin Zimmerman Doug and Carol Moore The Semler Family Foundation Gem-Young Insurance & Financial Service, Inc. Goelzer Investment Management Founder Lehmann Eye Center Anonymous Gaughan Family Foundation The O’Conner-Campion Family Charitable Fund Bill Grube Tom D. Kievit Joseph and Geraldine La Motta W.H. Voll Gifts from $5,000 to $9,999 Fredric and Myrna Gershon Walter and Janet Gross Limberg LASIK Institute Milauskas Eye Institute Jewish Communal Fund LaserVue Frederic and Frances Nathan Price Vision Group Dr. Francis W. Price, Sr. Schneider Vision San Antonio Eye Specialists Kenneth Swedo Bluestein Custom Vision Wilton J. Johnson Fellows Gifts from $1,000 to $2,499 Kenneth Anderson Huntington National Bank Benefactors Gifts from $2,500 to $4,999 Transplant Bank Gordon & Weiss Vision Institute Bucci Vision Patrons Indiana Lions Eye and Tissue Buckley Chang Eye Institute Joseph M. & Barbara Cohen Foundation, Inc. Gifts from $10,000 to $24,999 Homewood Suites—Keystone Eye Center of North Colorado Gifts $25,000 or greater Humanitarians Jerry Grage Calumet Lubricant “Thank you so much for all your time, effort and professionalism during all my questions, phone calls and visits. You were awesome! It would have been impossible to decide on crosslinking without your knowledge and information you shared with me. You have a great team!” Joseph Benitez Jr., MD Lenore Anderson Endowment Kathryn Lumb Shirley Mitchell William and Margaret O’Conner Ron Roach Synergeyes The UPS Foundation, Inc. Norwood A. Whitfield Joseph and Kay Wiley Donald and Janet Baumgartner Peter Burchanowski Roland and Pat Chastain Friends Gifts from $250 to $499 Michael Mullen Marsha Murman Gregory and Robin Pemberton Joseph and Deborah DeRanieri Sherry and Douglass Abney Adam Reising, OD Michael Dickerson Accenture Ronald G. Salatich - Donna L. Marvin Cave David and Laurie Hill Chapman Carter Eye Center Sidney and Lois Eskenazi Katzen Eyecare and Laser Center Eye Physicians, Inc. Without you, we could not do what we do. We thank our generous supporters. Vincent Wagner Rick Bruno Garry and Diane Warner Phillip & Shirley Buchanan Roy Michael Whetstine Theodora Callas Carolyn Mock Marcus and Marylou Winslow Claire Cartmell James and Doris Morton Thelma J. Woodring Susan Cassudakis Christine and Edward Muransky Jack and Florence Wright Harold Chambers Friends (continued) Gifts from $100 to $249 Friends (continued) Thomas Boone Steven and Leslie Gordon Frederic and Jane Nott Paul Wussow Timothy and Susan Cianciola Gifts from $250 to $499 Fred and Ellen Boso Wayne and Marilyn Greve John and Toula Oberlies Connie Zambelli Linda Cline Scheid Realty Fred and Sandra Brown Maurice Hahn Elizabeth Pasut Noha Khouri James and Pearlie Corbitt Jay and Mary Sue Schwartz Michael Bruno James and Jean Harrington Edwena Payne Joumana Seifeddine Vera Cox Harold A. Sherline Carmen Bullock, OD Robert and Amy Hendricks Albert and Audrey Pekelney Joseph and Chery Crum Bob Smelser Timothy Buren Diane Hido John Peters, MD William Stifle James and Charlotte Butler Robert and Elizabeth Hiller Angela and Francis Pierce Friends Billy and Natalie Cupler Janet and Gary Taylor Robert and Mary Ann Campbell David Huse, DVM Larry and Jessie Rash Gifts up to $99 James Daprile Temp Control Service Laverne and Ruth Ann Clingenpeel Linda and Richard Hutchinson Judith A. Ratliff Carmela Abraham Kimberly Davis Jeffrey Thacker Bopp-Busch Manufacturing Company Jack Frisch & Associates Reddington Christian Church John Arditi Chris and Cheryl DeHoff Trendy Trousseau LLC Mary Conners Jostad Enterprises Roger Reichmuth Peter and Sharon Asimakopoulos Susan Domer Marie Cormican Kathy Kelley, OD Jack and Joetta Riggin Neal and Suha Atway Linda Eyer Friends Patricia Cowan Betty and Robert King Salem Women’s Care, Inc. Mr. and Mrs. Jack J. Baker Samuel Faccioben Baker and Daniels Fred and Vicky Kline Harry W. Scheid Lucina Barnum-Steggerda James and Martha Fairfield Gifts from $100 to $249 Joseph Daprile Seneca One Realty, LLC Larry Sebeckis John and Mary Battaglia Gerald Fallon Dr. Keely Allen Victor Daprile Dr. Alfons Landwehr Deborah Shepherd Howard and Carla Beeson Drew Fasseas Mary Alice Andrews David and Linda Daringer Jack and Joan Lane James and Mary Shepherd Lester Beisner John Fazzone Anna Mae Lane Ted and Janet DeGarmo Judith Lasky, PhD Helaine Simon Virginia Belcher Timothy and Ruth Franklin Donald and Michele Argay Myron and Nancy Dickerson Eli (Ted) Lilly II Howard Steiner Betty Belschwender Margaret Freeman Leland and Carol Ballard Steven Doi, OD Guy and Arleen Lucci John and Eileen Takach Stephen and Cynthia Bennett Tonya and Brian Frost Richard and Karen Banning Harry Donovan James and Theresa Maciver Patricia Thomas Julie Benson Royce Garrett Sadie Barger Robin Felkins Gayle Mason Sherill and Delbert Thornburg Mark and Michelle Billy Cecelia Gastelum Jeffrey Barnaby Sheila Fiala Robert and Alana Mauzy David and Joyce Thurman Daniel and Rosemary Blilicki Karen Giorgetti Duane and Nancy Bassett Timothy M. Fischer Alan and Margaret McCall George and Angela Tzakis Paul and Jayne Boucherle Sydelle Golub Beckwith, Daprile & Co. JP Morgan Chase Foundation Rue and Carolyn McFarland Michael and Rebecca Unfried William W. and P.A. Bromer William P. Goodman, III Larry and Sue Bennett John Frank Ralph Michalec Colleen Vella Brent Brown Brian and Melinda Governor Jeffrey Boller William Golfsmith Wendy Mickler Earl and Martha Vogt Susan Taracuk Brown Dorothy Grainger Anthony and Amy Daprile We thank our generous supporters. Friends (continued) Gifts up to $99 Steven and Sally Warden Lisa and Andrew Weiss Phillip and Jacquelyn Weybrant Friends (continued) Lucinda Barnum-Steggerda in honor of Robert Barnum Seneca One Realty, LLC in honor of Jane Kelsch Mary Lynn McIntyre in memory of Charlie Anne Newton Paul Whitehead Michael Kovatch Stepheny and James Pisciuneri Mark and Georgia Wilson Matthrew Kusy William and Debra Pisciuneri Thomas Green Barbara Woerner Joseph and Mary Jo Lenefonte Richard Preske Donna Griesmer James Wood Amanda Lopez James and Julie Rafoth Joan Hackler John Yerian Anne-Marie and Mark Luchansky Lee Rasamny David and Traci Hardy Jaime and John Yohman Steven and Palan Lussier Glendolyn Rhymer Jennifer and Paul Harris Anthony and Concetta Young Neva Maloy Bessie and Melissa Rice Max and Eldred Hauk Lynn Scarnati Zvara Dawn Marzano Mark and Nancy Sabol Michael and Marsha Hile Michael Thomson George and Beverly Mattox Michael Schaub Carol Hinkle Annabelle Willett Donnalou and Patrick McVay Kurt Schwant Dale and Jo Ann Hoepf Virginia L. Merillat Daniel Schwartz Sarah Hoover Jemilla Kidanu Michael Connie Shepherd Marceda Hosted Helen Miller Charles and Shirley Shoppell Robert Hotchkiss Norman T. Mills Rita Sibert Pamela Hudson Annabella and Dominador Miranda Robert D. Sipress Dorothy Ann Hummel Toby and Janet Mirto Catherine Slovan John W. Hussey Richard and Cherie Mize Marlyse Spicer Samuel Jacobs Kamel Muakkassa Erwin F. Springer David and Michelle Jakovina Joyce Nevil Stanich SCP Greg Jansen Elaine and Donald Newman Pamela Steinhauser Jaime Jarvis David and Candice Niederhaus Phil Stuart, OD Doris M. Johmann Richard and Nancy Novotny Marilyn Sullivan Myron and Rose Jane Kaiser Vilma Ortiz Doris Szijj Megan and Roland Kaleel Asha and Sushil Pandhi Joseph and Debbie Thomas Carol Kalp Martin and Teresa Papai Judith Thomas Julie Kamenitsa Richard and Phyliss Paul Tunno Insurance Agendy Roger and Ellen Kinsey Patricia A. Peters Nancy and Michael Vince Gifts up to $99 Honor and Memorial Contributions Study Related Income Alcon Laboratories ISTA Pharmaceuticals Allergan Jaeb Center for Health Research, Inc Avedro Patient Education Concepts/CRM Case Western Reserve University Trial Runners, LLC Cook Pharmaceuticals University of Illinois– Chicago Inc Research, Inc. You help make better vision possible. Key Research Areas Preventing Cornea Transplant Rejection DMEK—The Latest Advancement in Cornea Transplants One of the biggest risks transplant recipients face is that immunologic graft rejection will cause the new Exciting News donor cornea to fail. Corticosteroid eye drops are Decreased risk of rejection from 12 percent to less than 1 percent! typically used for months or even years to prevent cornea transplant rejection. Unfortunately, these eye drops have some serious side effects. Surprisingly, no prospective randomized studies have been done to determine the best corticosteroid-dosing regimen, so solid evidence on what is the best dosing for transplant patients is lacking. We have found that the new, minimally invasive transplant procedure called DMEK has a very low risk of rejection. So we have initiated a large study to see if we can reduce the topical corticosteroid strength, and avoid some of the steroid side effects, while maintaining a low risk of rejection after DMEK. We will enroll 440 patients in the study Corneas are about the thickness of a credit card and are comprised of three distinct layers. Although corneal problems are usually localized to just one or two layers, the traditional approach was to replace them all. In Figure 1 below, the arrow is pointing to a single line—this is the thickness of a cornea transplant using the DMEK technique. In Figure 2, the overall length of the red arrow represents the thickness of a full thickness transplant. Dr. Price helped pioneer cornea transplant techniques that replace only the diseased portion of the cornea, leaving healthy layers intact. Only the ultra-thin cell layer lining the inner surface of the cornea is diseased in about half the patients who need a transplant. According to Dr. Price, ―Replacement of the inner cell layer with a single cell layer from a donor cornea (a technique known as DMEK) provides much better and faster visual recovery than earlier methods.‖ The reason cornea transplants fail is because the recipient’s body can recognize the donor tissue as foreign and mount an attack against it. Our research has found that single layer DMEK grafts are 15- to 20 -times less likely to be rejected than earlier techniques that include two or more layers of the cornea. According to Dr. Price, ―99% of our DMEK recipients remain rejection-free at two years and beyond. Having a transplant technique that can better elude rejection is a huge breakthrough for cornea transplant recipients.‖ and follow each patient for one year. This landmark study will provide valuable new information to help cornea transplant recipients maintain newly restored vision. FIGURE 1 DMEK FIGURE 2 Full Thickness Transplant Each year approximately 42,000 Americans need a transplant to replace the cornea, the clear window on the front surface of the eye. Cornea transplants usually remain clear for at least 10 years, but in some patients they fail much sooner. We are working to figure out why transplants sometimes fail early and to develop innovative treatments to extend transplant survival. We are doing this by removing and analyzing fluid from inside the eye, called the aqueous humor. The fluid bathes the back surface of the cornea and provides key nutrients that help maintain the health of the cornea. In this study we will identify the changes that occur in this fluid when a cornea transplant starts to fail. This study will provide key information needed to help maximize cornea transplant survival. We’re evaluating up to 360 subjects. Key Research Areas Key Research Areas Improving Cornea Transplant Survival In earlier studies, we found that patients who have had glaucoma surgery are at particularly high risk for early cornea transplant failure, and we identified some intriguing changes that occur in the fluid inside the eye after glaucoma surgery. We are following up on these promising discoveries by collecting and analyzing aqueous humor samples from cornea transplant recipients who are at increased risk of graft failure either because they had prior glaucoma surgery, they had an acute immunologic graft rejection episode, or they experienced a sudden loss of cells from the back surface of the cornea for unknown reasons. Fluid samples collected from uncomplicated eyes with a previous corneal transplant serve as controls. Vision Correction Method Study— LASIK/Contact Lenses The Foundation is conducting a national clinical survey study comparing visual results, patient satisfaction and quality of life issues as they relate to LASIK and contact lenses. This is the first prospective study to follow these two popular methods of vision correction for nearsightedness, astigmatism, and farsightedness simultaneously. Patient consents and surveys are conducted over the internet using a HIPAA compliant web portal that will automatically coordinate future patient surveys at the one, two and three-year anniversaries of the study date of entry. Our goal of the study is to enroll between 2 and 5 thousand patients - both those undergoing LASIK, and patients who will continue to wear contact lenses. We will determine if visual satisfaction, visual complaints and safety – as reported by participants – are similar or different between the two groups. Study sites throughout the United States are currently enrolling patients in the study. For a complete listing of our current studies, please visit www.cornea.org and click on Research and then Current Studies. Foundation Staff Award Winning Research Board of Directors Marianne O. Price, Ph.D. Drs. Price receive Santa Catarina Award in Sienna, Italy Francis W. Price, Jr., MD Founder and Chairman Executive Director Jessica Dingledy Development Director Clorissa Quillin Research Coordinator Kelly Fairchild Research Coordinator Maraya Baumanis Research Intern Lauren Gunderson Research Intern Francis W. Price, Jr. , MD and wife Marianne Price, PhD were presented with the ―Santa Caterina Oro Città di Siena‖ International Prize on February 27, 2011 in Siena, Italy. Drs. Price traveled to Siena and were honored at the ceremony receiving the Santa Caterina gilded statue at the Teatro dei Rozzi in Siena. Francis W. Price Jr., MD of Price Vision Group is the founder and president of the Cornea Research Foundation of America, and his wife, Marianne is the Foundation’s executive director. Together they were chosen as recipients of the Santa Caterina prize as their research has led to significant improvements in cornea transplant surgery and treatment of eye diseases around the world. Each year, ten recipients from different areas of expertise all over the world are selected to receive this prestigious award. The Prices commented, ―We feel blessed to have found better ways to give people back the use of their eyes and to have had the opportunity to share improved techniques with eye care professionals nationally and internationally.‖ For more information, visit http://www.cornea.org. F. W. (Bill) Grube Vice President Trischa L. Zorn-Hudson Secretary Walter C. Gross., Jr. Treasurer Jim Butler Frank Clifford Michael W. Dickerson Phil Gibson Robert Grimm David C. Huse Toula Oberlies Jerry D. Semler Events Focus on Education Optometrist Seminar November 2010 Each year the Foundation sponsors an all-day seminar for optometrists that features programming on the latest treatments and surgeries available for the anterior segment of the eye and cornea. Attendees earn approved continuing education credits while learning about the newest ophthalmic medical devices, pharmaceuticals, and practice management techniques. The Foundation would like to thank all of those who served on our Cornea Classic Golf Committee for organizing a successful golf outing on June 2, 2011 at Wood Wind Golf Club in Westfield, Indiana. The event raised nearly $28,000 to fund our mission to provide research and education to preserve and restore vision. Thanks to all who donated, sponsored and participated in the event. The outing will be held on June 21, 2012 next year. If you would like to receive the registration form in February, give us a call at 317-814-2993. Golf Committee Harry W. Scheid Chairman Vern Rensing Vice Chairman Pat Chastain Mike Dickerson Phil Gibson Walter C. Gross, Jr. Mark Horton Joe Kack Francis W. Price, Jr., June 2011 Cornea Classic Golf Outing a Success PUBLICATIONS Guerra FP, Price MO, Price FW. Is central pachymetry asymmetry between eyes an independent risk factor for ectasia after LASIK? J Cataract Refract Surg 2010;11:2016-7. Letko E, Price DA, Lindoso EM, Price MO, Price FW. Secondary Between July 1, 2010 and June 30, 2011 graft failure and repeat endothelial keratoplasty after Descemet's stripping automated endothelial keratoplasty. Ophthalmol 2011;118:310-4. Hayes DD, Shih CY, Shamie N, Terry MA, Price FW Jr, Price MO, Ritterband DC, Hannush SB, Gorovoy MS, Weisenthal RW, Ritch R, Liebmann JM, Udell IJ. Spontaneous reattach- Click on the blue hyperlinks to read each publication. Price FW, Price MO, Arundhati A. Descemet stripping automated endothelial keratoplasty under failed penetrating keratoplasty: how to avoid complications. Am J Ophthalmol 2011;151:187-8. Olson R, Donnenfeld D, Bucci FA, Price FW, et al. Methicillin resistance of Staphylococcus species among health care and nonhealth care workers undergoing cataract surgery. Clin Ophthalmol 2010;4:1505-1514. Da Reitz Pereira C, Guerra FP, Price FW Jr, Price MO. Descemet's membrane automated endothelial keratoplasty (DMAEK): visual outcomes and visual quality. Br J Ophthalmol 2011;95:951-4. Richardson MR, Segu ZM, Price MO, Lai X, Witzmann FA, Mechref Y,Yoder MC, Price FW. Al- terations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy. Molecular Vision 2010; 16:2376-2383 http://www.molvis.org/molvis/ ment of Descemet stripping automated endothelial keratoplasty lenticles: a case series of 12 patients. Am J Ophthalmol 2010;150:790-7. Price MO, Price FW. Deep thalmol 2010;94:1275-6 anterior lamellar keratoplasty: coming of age. Br J Oph- Price MO, Price FW. Descemet mol Clin 2010;50:137-47. membrane endothelial keratoplasty. Int Ophthal- Price MO, Price DA, Fairchild KM, Price FW. Rate and risk factors for cataract formation and extraction after Descemet stripping endothelial keratoplasty. Br J Ophthalmol 2010;94:1468-71 Kwon RO, Price MO, Price FW, Ambrosio R, Belin MW. Pentacam characterization of corneas with Fuchs dystrophy treated with Descemet membrane endothelial keratoplasty. J Refract Surg 2010;26:972-9. v16/a255 McCauley MB, Price MO, Fairchild KM, Price DA, Price FW. Prospective study of visual outcomes and endothelial survival with Descemet membrane automated endothelial keratoplasty. Cornea 2011;30:315-9. Price MO, Fairchild KM, Price DA, Price FW. Descemet's stripping endothelial keratoplasty five-year graft survival and endothelial cell loss. Ophthalmology 2011; 118:725-9. For a complete listing of our publications, please visit www.cornea.org and click on Research and then Publications. MEETING PRESENTATIONS Between July 1, 2010 and June 30, 2011 Eye Bank Association of American Annual Meeting, Tucson, AZ, June 2011. Price MO, Gorovoy M, Benetz BA, Price FW, Washington K, Debanne S, Menegay H, Lass J. DSAEK outcomes at three years compared with penetrating keratoplasty from the Cornea Donor Study. Eye Bank Association of America Scientific Session, June 25, 2011, Tucson, AZ. Soper M, Price MO. Eye bank preparation of DMAEK tissue (DMEK with stromal ring). West Virginia Academy of Eye Physicians & Surgeons annual meeting, White Sulfur Springs, WV. June 2011 Price FW, Price MO. The current state of the art in corneal crosslinking. Price FW, Price MO. Anterior lamellar keratoplasty.. Price FW, Price MO. Evolving surgical techniques in endothelial keratoplasty. Price MO, Price FW. Glaucoma/IOP control, topical corticosteroid use, and immunologic graft rejection with endothelial keratoplasty. Price MO, Price FW. Management of cataracts in patients with Fuchs’ dystrophy. Price MO, Price FW. Long term endothelial keratoplasty survival and risk factors for graft failure. Association for Research in Vision and Ophthalmology annual meeting, Ft. Lauderdale, FL. May 2011 Price MO, Anshu A., Price FW. Outcomes of endothelial keratoplasty under failed penetrating keratoplasty. American Society of Cataract and Refractive Surgery annual meeting, San Diego CA, March 2011 Guerra F, Price MO, Price FW. Fellow eye comparison of DSAEK and DMEK. (Best Cornea poster award). Arundhati, A, Price MO, Price, FW. Descemet-stripping endothelial keratoplasty survival outcomes in eyes with preexisting glaucoma. Guerra F, Ambrosio, R, Price MO, Price FW. Preliminary results of enhanced ectasia screening of refractive surgery patients based on corneal tomography. Arundhati A, Price MO, Price FW. Outcomes of endothelial keratoplasty under penetrating keratoplasty. Planchard B, Price MO, Price FW. Retained viscosurgical device as cause of interface haze after Descemet-stripping endothelial keratoplasty. Price FW, Price MO. Setting new benchmark for LASIK. Societa Italiana Trapianto di Cornea annual meeting, Bologna, Italy, February 2011 Price FW, Price MO. Ten years experience with endothelial keratoplasty. (Keynote lecture). Price MO, Price FW. Long term visual outcomes and graft survival after DSAEK. (Keynote lecture). International Innovation Technology Meeting, Mendoza Argentina, December 2010 Price FW, Price MO. New indications for corneal collagen cross linking. Price FW, Price MO. Endothelial keratoplasty under failed penetrating keratoplasty: how to minimize complications. Price FW, Price MO. DMEK and DMAEK: patient selection and how to optimize visual results with endothelial keratoplasty. (Keynote lecture). Price MO, Price FW. DSAEK long-term graft survival and comparison with PKP. (Keynote lecture). Price MO, Price FW. Impact of glaucoma on DSAEK: is it different from PKP? Price MO, Price FW. What has been learned about graft rejection? Asian Cornea Society Bi-annual Meeting, Kyoto, Japan, December 2010. Price FW, Price MO. Endothelial Keratoplasty Overview: where are we now and where are we going? (Keynote lecture). Price FW, Price MO. Long-term Outcomes of DSEK/DSAEK. (Keynote lecture). Price FW, Price MO. Surgical tips for DMEK and DMAEK. Price MO, Price FW. What have we learned about IOP control and outcomes in DSEK/DSAEK eyes with and without glaucoma? Price MO, Price FW. Outcomes of DMEK, DMAEK, and eye bank prepared DMAEK grafts. Cornea Society/EBAA Fall Educational Symposium, Chicago, IL, October 2010. Price MO, Soper M, Price FW. Use of eye bank-prepared donor tissue for Descemet membrane automated endothelial keratoplasty (DMAEK). Price FW, Price MO, Guerra F, Schrier A. Prospective randomized trial of cross-linking for infectious keratitis. Guerra F, Price MO, Price FW. Fellow eyes comparison of DSAEK and DMEK. American Academy of Ophthalmology annual meeting, Chicago, IL, October 2010. Price MO, Price FW. Do Larger Descemet Stripping Endothelial Keratoplasty Grafts have Better Long-term Endothelial Cell Density? (Best poster award). European Society of Cataract and Refractive Surgery annual meeting, Sept 5, 2010, Paris, France. Price FW. Outcomes with Femtosecond laser assisted corneal transplants over a 4.5 year period. Price MO, Price FW. Five year graft survival of Descemet stripping endothelial keratoplasty. Price FW, Price MO. Prospective multi-center analysis of 1-year outcomes with DMEK. Price FW. Cross linking for the treatment of corneal infections. Price FW, Price MO. DSAEK: five-year results. Aegean Cornea Congress, Crete, Greece, July 2010. Price FW. Current Status of Posterior Corneal Transplantation. Thank you for taking the time to review our 2011 Annual Report. If you have any questions regarding the information inside, or would like to speak with someone about making a gift or volunteering in our office, please call us at 317-814-2993. Do you receive our Focus E-Newsletter? If you do not, and you would like to be kept up to date on our research, please email Jessica@cornea.org to be added to the mailing list. Interested in volunteering? No one understands the importance of better vision more than we do. 9002 N. Meridian St. Suite 212 Indianapolis, IN 46260 Conducting research today for brighter futures tomorrow. W W W. C O R N E A . O R G
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