Chemical Network

Lonza’s chemical network
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Pharma&Biotech
Nutrition
Agriculture
MaterialsScience
PersonalCare
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Content
About Lonza
3
Introduction
4
Diketene / ketene derivatives
6
Esters
Arylides
Alkylamides
Pyrazolones
Dehydroacetic acid
Lonzamon monomers
Other diketene derivatives
6
7
8
9
9
10
10
HCN derivatives
12
Heterocycles
14
Basic chemicals
16
Others
17
Alphabetical index
18
About Lonza
From 1897 to the present day combining Swiss tradition with global
experience, the company has had an enterprising character, adapting
its offerings and services to the needs of customers and to changing
technologies. Throughout our history, we have maintained a strong
culture of performance, results and dependability that is valued by all
of our customers.
Lonza is the global leader in the production and support of active pharmaceutical ingredients both chemically and biotechnologically. Biopharmaceuticals are one of the key growth drivers of the pharmaceutical and
biotechnology industries.
Lonza has strong capabilities in large and small molecules, peptides,
amino acids and niche bioproducts which play an important role in the
development of novel medicines and healthcare products. In addition,
Lonza is a leader in cell-based research, endotoxin detection and cell
therapy manufacturing. Furthermore, the company is a leading provider
of chemical and biotech ingredients to the nutrition, hygiene, preservation, agro and personal care markets.
Lonza’s cracker in Visp is the back bone of a comprehensive fully backward integrated chemical network. Our product portfolio consists of
HCN- and diketene derivatives as well as basic chemicals which are key
raw materials and intermediates for many sophisticated applications.
3
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Diketenes / ketenes
Diketene is a colorless liquid produced by dimerization of ketene. It is
a highly reactive building block which can be combined with numerous
other chemical compounds to make a wide range of products. Because
of its high energy content, transport of diketene is forbidden. It is processed further at the site of manufacture. Lonza is one of the world’s
leading suppliers of diketene derivatives manufactured in its production
facility in Visp, Switzerland. Our diketene derivatives are used in the
pharmaceutical, vitamin, agrochemical and pigment industries. The
niche markets are in cosmetics, plasticizers, paints. The acetoacyl group
in diketene derivatives has a broad functionality which can be used
for the production of further products. Lonza’s most comprehensive
diketene product lines are those made with alcohols (aceto-acetic acid
and acrylate derivatives), aliphatic amines (alkylamides) and aromatic
amines (arylamides). Lonza uses some of these to produce further
components (pyrazolones, aminocrotonates, side chains).
Alkylamides: Aliphatic amines react with diketene to result in alkylamides. Major products such as monomethyl- or dimethylacetoacetamides are manufactured as aqueous solutions with continuous processes; other derivatives and water-free compounds are produced with
batch processes. The (alkyl-) acetoacetamides are used principally in
the manufacture of insecticides. The derivatives are also deployed in
the pigment, pharmaceutical and polymer industries.
DHS / NaDHS: The catalytic dimerization of diketene yields dehydroacetic
acid (DHS), which is a solid material. The free acid can be neutralized
with sodium hydroxide and is available as the salt NaDHS or its monohydrate NaDHS-H2O. These products are used above all in the manufacture
of PVC stabilizers and as preservatives in the cosmetic industries.
Acrylic acid esters (acetoacetoxy monomers): Acetoacetoxyethyl methacrylate (AAEMA), the most important product of this group, is made
in a multipurpose batch production plant. It is used as a copolymer for
coatings and adhesives in emulsion polymerization (waterborne dispersions) or solvent polymerization (high solids), and provides improved
mechanical and solvent resistance to water or organic solvents. It also
promotes adhesion to metallic, mineral and wood surfaces.
The following summary provides an overview of the diketene derivative
product groups:
Diketene esters (acetoacetates): “Major” products such as methyl,
ethyl, isopropylester of acetoacetic acid are produced in a continuous
process and purified by distillation. “Minor” derivatives are produced
batchwise in stirred vessel reactors. The products are used mostly in
the dye, agrochemical, pharmaceutical and vitamin industries.
Other diketene derivatives: 4-Chloroacetoacetic acid ester is a highly
versatile diketene derivative. It can be used in syntheses of various
pharmaceutical intermediates.
Arylamides: A large variety of arylamides are obtained by the reaction
of aromatic amines with diketene. Our most important products are AAA,
AAOT, AAMX, AAOA, and AAOC; others are made regularly or on special
request. These derivatives are used mainly in the production of azo
pigments; but also in the dye and agrochemical industries.
Ketene: Lonza has the specific capability to perform a variety of reactions with ketene. The production of ethyl 4, 4, 4-trifluoroacetoacetate
is one example for such a ketene reaction.
For more information about ketene / diketene chemistry and its various
derivatives, please ask for specific brochures and related literature or
send mail to diketene@lonza.com.
4
Hydrocyanic acid (HCN)
Hydrogen cyanide is a extremely poisonous colorless or pale-blue liquid
that undergoes a wide variety of reactions. Lonza has manufacturing
capabilities to offer a solution of hydrogen cyanide in water (hydrocyanic acid) and producing its derivatives. HCN is used in metallurgical
and photographic processes. Furthermore, HCN is a starting material
for cyanogen chloride, cyanoacetates, cyanohydrins, sodium cyanide,
chelating agents and many more. Cyanogen chloride is a functional
building block for other Lonza products like cyanuric chloride and malononitrile. The cyanohydrins, give access to a variety of useful organic
compounds including the monomer methyl methacrylate, amino acids
via the Strecker synthesis, and the chelating agents EDTA and NTA.
Basic chemicals
Beside ketene and HCN chemicals Lonza’s cracker related product portfolio also offers a selective number of basic chemicals. The chemicals
can be used as starting materials and processed further to yield coatings, colorants, adhesives, medicines, agrochemicals and more.
Icons
Pharma
Colorants
Agriculture
Polymers
Nutrition
Various
5
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Diketene / ketene
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Esters
Methyl acetoacetate (MAA)
Ethyl acetoacetate (EAA)
C5H8O3
C5H10O3
Isopropyl acetoacetate (IPAA)
Isobutyl acetoacetate (AAisobutyl)
t-Butyl acetoacetate (AA-t-butyl)
C7H12O3
C8H14O3
C8H14O3
144.17
542-08-5
98.5 %
2 years
–27°C
185°C
0.998
Xi irritant
drums, bulk
not restricted
116.12
105-45-3
99.0 %
2 years
–28°C
170°C
1.077
Xi irritant
drums, bulk
not restricted
158.20
7779-75-1
98.0 %
2 years
–20.5°C
205°C
0.974
–
drums
not restricted
130.14
141-97-9
99.0 %
2 years
–43°C
180°C
1.03
–
drums, bulk
not restricted
158.20
1694-31-1
98.0 %
2 years
–38°C
71°C / 15hPa
0.970
–
drums
not restricted
Benzyl acetoacetate (BAA)
N-Benzyl-N-methyl-2-aminoethylacetoacetate (AABME)
Dodecyl acetoacetate (AAdodecyl)
C11H12O3
C14H19NO3
C16H30O3
192.22
5396-89-4
–
2 years
12°C
275°C dec.
1.114
Xi irritant
drums
not restricted
249.31
54527-65-0
95.0 %
8 months
–
175°C dec.
1.067
–
drums
not restricted
6
270.42
52406-22-1
96.0 %
2–3 years
–
190°C /20 hPa
0.914
Xi irritant
drums
not restricted
2-Methoxyethyl acetoacetate
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Ethyl benzoylacetate-91 (BESethyl-91)
(AAmethoxyethyl)
4-Nitrobenzyl acetoacetate
(30 % in toluene) (PNBAA 30T)
C11H12O3
C7H12O4
C11H11NO5
192.22
94-02-0
91.0 %
2 years
–
93°C / 10 Pa
–
–
drums
not restricted
Arylides
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
160.16
22502-03-0
97.5 %
2 years
–
118°C / 26hPa
1.091
T toxic
drums
not restricted
237.21
61312-84-3
270-330 g/l
9 months
–
–
–
F, Xn; R11-38-48/20-63-65-67
iron drums 56.25 kg, 187.5 kg
UN 1993, 3, PG II
Acetoacetanilide (AAA)
Acetoacetanilide, flakes (AAA,flakes)
C10H11NO2
C10H11NO2
177.20
102-01-2
99.5 %
2 years
83.0°C
–
–
Xn harmful
paper bags, big bags
not restricted
Acetoacet-o-toluidide (AAOT)
Acetoacet-m-xylidide (AAMX)
C11H13NO2
C12H15NO2
177.20
102-01-2
95.0 %
9 months
62.0°C
–
–
Xn harmful
big bags
not restricted
Pharma
Colorants
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
191.23
93-68-5
99.5 %
2 years
103.5°C
–
–
Xn harmful
paper bags, big bags
not restricted
205.26
97-36-9
99.5 %
2 years
89°C
–
–
Xn harmful
paper bags, big bags
not restricted
7
Agriculture
Polymers
Nutrition
Various
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Diketene / ketene
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Acetoacet-o-chloroanilide (AAOC)
Acetoacet-o-anisidide (AAOA)
Acetoacet-4-chloro-2,5-dimethoxyanilide (ASIRG)
C10H10ClNO2
C11H13NO3
C12H14ClNO4
211.65
93-70-9
99.5 %
2 years
103.5°C
–
–
Xn harmful
paper bags
not restricted
207.23
92-15-9
99.5 %
2 years
83.5°C
–
–
Xn harmful
paper bags, big bags
not restricted
Acetoacet-5-chloro-2-methoxyanilide (AAMOC)
Potassium N-(acetoacetyl)
sulfanilate (AAsulfanil-K)
C11H12ClNO3
C10H10KNO5S
241.68
52793-11-0
99.0 %
2 years
92°C
–
–
–
paper bags
not restricted
271.70
4433-79-8
98.0 %
2 years
104°C
–
–
Xn harmful
paper bags
not restricted
Alkylamides
295.36
70321-85-6
96.0 %
2 years
>300°C
–
–
–
paper bags, big bags
not restricted
N,N-Dimethylacetoacetamide
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
N-Methylacetoacetamide (MMAA)
(DMAA-80)
N,N-Diethylacetoacetamide (DEAA)
C5H9NO2
C6H11NO2
C8H15NO2
115.13
20306-75-6
70.0 %
2 months
–
110°C
1.078
–
drums, bulk
not restricted
129.16
2044-64-6
80.0 %
6 months
–
106°C
1.060
–
drums, bulk
not restricted
8
157.21
2235-46-3
98.0 %
3 months
–
213°C
0.995
–
drums, bulk
not restricted
Acetoacetamide (AAmid)
3-Methyl-5-pyrazolone (MP)
Pyrazolones
C4H7NO2
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
101.11
5977-14-0
98.5 %
18 months
52°C
–
–
–
paper bags
not restricted
C4H6N2O
98.11
108-26-9
99.0 %
2 years
217°C
–
–
–
drums
not restricted
Dehydroacetic acid (DHS)
3,5-Dimethylpyrazole (DMP)
Dehydroacetic acid
C5H8N2
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
96.13
67-51-6
99.0 %
3 years
107°C
218°C
–
–
drums
not restricted
Dehydroacetic acid, sodium salt
C8H8O4
168.15
520-45-6
99.0 %
2 years
109°C
–
–
Xn harmful
paper bags
not restricted
(NaDHS)
Dehydroacetic acid, sodium salt
monohydrate (NaDHS-H2O)
C8H7O4Na
C8H9O5Na
Pharma
Colorants
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
190.13
4418-26-2
99.0 %
2 years
–
–
–
Xn harmful
drums
not restricted
208.15
64039-28-7
98.0 %
2 years
109°C
–
–
Xn harmful
drums
not restricted
9
Agriculture
Polymers
Nutrition
Various
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
2-(Acetoacetoxy) ethylmetha­crylate
Diketene / ketene
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Lonzamon monomers
Propane-1.1.1-triyltrimethyl tris
(acetoacetate) (AATMP)
C10H14O5
C18H26O9
214.21
21282-97-3
95.0 %
1 year
–60°C
100°C / 1hPa
1.122
Xi irritant
drums
not restricted
Other diketene / ketene
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
(AAEMA)
Squaric acid (QS)
Diethyl squarate (QS, diethyl)
C4H2O4
C8H10O4
114.06
2892-51-5
98.5 %
2 years
293°C
–
1.82
–
drums
not restricted
Diacetoacet-1,4-phenylenediamide
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
386.4
22208-25-9
92.0 %
2 years
–30°C
300°C
–
–
drums
not restricted
170.17
5231-87-8
98.0 %
12 months
4–8°C (solidification)
95°C / 0.1 hPa
1.15
T toxic; R21-25-36/37/38-42-43
iron drums
UN 2810, 6.1, PG III
Diacetoacet-o-tolidide (DiAA-o-tolidid)
(DiAAphen)
Diacetoacet-2,5-dimethyl-1,4phenylenediamide (DiAA DM)
C22H24N2O4
C14H16N2O4
C16H20N2O4
380.45
91-96-3
98.0 %
2 years
206°C
–
–
–
bag-in-box, drums
not restricted
276.29
24731-73-5
98.5 %
2 years
171°C
–
–
–
paper bags
not restricted
10
304.38
24304-50-5
98.0 %
2 years
232°C
–
–
–
paper bags
not restricted
Diacetoacet-2-chloro-5-methyl-1,4phenylenediamide (DiAA MC)
Diacetoacet-2,5-dichloro-1,4pheny­lene­diamide (DiAA DC)
Methyl 3-aminocrotonate (ACMe)
C15H17ClN2O4
C14H14Cl2N2O4
C5H9NO2
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
345.18
42487-09-2
97.0 %
5 years
197°C
–
–
–
paper bags
not restricted
324.77
41131-65-1
97.0 %
5 years
192°C
–
–
–
paper bags
not restricted
1,4-Butyleneglycolbis
(3-amino­crotonate) (BGAC)
C12H20N2O4
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
115.13
14205-39-1
98.0 %
–
81°C
112°C / 55hPa
–
Xi irritant
drums
not restricted
Diketene-acetone adduct (DAA)
Thiodiglycolbis
(3-aminocrotonate) (TGAC)
C7H10O3
C12H20N2O4S
256.30
14205-47-1
96.0 %
2 years
146°C
–
–
–
bag-in-box
not restricted
142.16
5394-63-8
93.0 %
3 months
12°C
66°C / 3mbar
1.094
F flammable
drums
UN-No.: 1993, 3, PG II
2,5-Dimethyl-2,4-dihydropyrazol-3-on (DMPO)
Ethyl 4-chloroacetoacetate (CAAEt)
C5H8N2O
C6H9ClO3
288.37
13560-49-1
96.0 %
2 years
88°C
–
–
N environment
fibre container
UN-No.: 3077, 9, PG III
Pharma
Colorants
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
112.13
2749-59-9
>98.0 %
–
117–118°C
105–115°C / 8 hPa
1.14
Xi irritant
–
not restricted
164.59
638-07-3
97.0 %
1 year
–8.5°C
220°C
1.212
T toxic, N environment
drums
UN-No.: 2922, 8, PG II
11
Agriculture
Polymers
Nutrition
Various
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Diketene / ketene
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Ethyl 4,4,4-trifluoroacetoacetate
Methyl 3,3-dimethoxypropanoate
(E)-Methyl 3-methoxyacrylate
(ETFAA)
(PRSMe,DM)
(E-MMA)
C6H7F3O3
C6H12O4
C5H8O3
184.12
372-31-6
98.0 %
6 months
–39°C
131°C
1.2586
Xn harmful
drums
not restricted
148.16
7424-91-1
98.0 %
12 months
<–65°C
77°C / 26 mbar
1.06
–
–
not restricted
116.12
34846-90-7, 5788-17-0 (linear structure)
≥98.0 %
2 years
2–3°C
95°C / 100 hPa
1.07
–
–
not restricted
Methyl 4-methyl-3-oxopentanoate
(OPMe, 4-methyl)
C7H12O3
Pharma
Colorants
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Agriculture
144.17
42558-54-3
98.0 %
12 months
–75°C
192°C
1.01
–
drum or iso-container
not restricted
Polymers
Nutrition
Various
Adenine
Cyanuric chloride A (CC A)
Cyanuric chloride AS (CC AS)
HCN
derivatives
C5H5N5
C3Cl3N3
C3Cl3N3
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
135.13
73-24-5
98.0–102.0 %
2 years
360°C
–
–
–
drums
not restricted
184.41
108-77-0
99.5 %
6 months
145.0–147.0°C
193°C / 1013 hPa
–
–
bags in box
not restricted
12
184.41
108-77-0
99.5 %
6 months
145.0–147.0°C
193°C / 1013 hPa
–
–
big bags
not restricted
2-Methoxyethyl cyanoacetate
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Allyl cyanoacetate (CNESallyl)
Butyl cyanoacetate (CNESbutyl)
(CNES methoxyet)
C6H7NO2
C7H11NO2
C6H9NO3
125.13
13361-32-5
99.0 %
2 years
–40°C
89–90°C / 5 hPa
–
T toxic; R25
drums 200 kg
UN 3276, 6.1, PG III
141.17
5459-58-5
99.0 %
2 years
–
109.0°C / 13.0 hPa
0.998–1.002
–
drums 200 kg
not restricted
143.14
10258-54-5
≥99.0 %
2 years
–
257°C / 1000 hPa
–
–
iron drums 200 kg, container
not restricted
Malononitrile (85 % in methanol)
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Chlorosulfonyl isocyanate (CSI)
Malononitrile (MDN)
(MDN)
CClNO3S
C3H2N2
C3H2N2 ; CH4O
141.53
1189-71-5
99.0–100.3 %
12 months
–
1060°C
1.626
C corrosive; R14-20/21/22-34
drums
UN 3264, 8, PG I
66.06
109-77-3
99.0 %
18 months
–
218–219°C
1.0494 (35°C)
T toxic, N environment; R23/24/25-50/53
drums
UN 2647, 6.1, PG ll
98.11
109-77-3
83.5–86.5 %
2.5 months
19.5°C
–
1.011 (35°C)
T,N; R10-23/24/25-39/23/24/25-50/53
drums, rail tank wagon
UN 2929, 6.1 (3), PG ll
3-Aminocrotononitrile (Diacetonitril)
Sodium dicyanamide (Na-dicyanamide)
1,1,3,3-Tetramethylguanidine (TMG)
C4H6N2
C2N3Na
C5H13N3
82.11
1118-61-2
96.0 %
8 months
40–67°C
–
0.9520 (77°C)
–
drums
not restricted
89.03
1934-75-4
≥97.0 %
2 years
>260°C
–
–
–
drums, BB packaging on request
not restricted
13
115.18
80-70-6
99.0 %
1 year
–
162°C / 1013 hPa
0.92
–
drums, bulk
not restricted
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Akolidine 10
(Pyridine, alkyl derivatives)
Heterocycles
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Akolidine 11
(Pyridine, alkyl derivatives)
Akolidine 12
(Pyridine, alkyl derivatives)
All akolidines contain the following components:
–
68391-11-7
–
–
–
–
0.978–0.990
–
iron drum, bulk
not restricted
–
68391-11-7
–
–
–
–
1.018–1.034
–
iron drum, bulk
not restricted
–
68391-11-7
–
–
–
–
1.024–1.038
–
iron drum, bulk
not restricted
2-Amino-4,6-dimethoxypyrimidine
2-Chloro-4,6-dimethoxypyrimidine
2-(5-Ethyl-2-pyridyl)ethanol
(ADMP)
(DMP, 2-Chlor)
(PRD-2-etol, 5-Et)
C6H9N3O2
C6H7ClN2O2
C9H13NO
155.16
36315-01-2
98.0–101.0 %
2 years
96–98°C
–
–
–
drums
not restricted
174.59
13223-25-1
98.0–100.3 %
2 years
102–104°C
–
–
–
drums
not restricted
151.21
5223-06-3
95.0 %
2 years
45°C 147–149°C
1.042
–
iron drum 200 kg
not restricted
5-Ethyl-2-methylpyridine (MEP)
6-Hydroxynicotinic acid (NS,6-Hydroxy)
Sodium nicotinate (NS-Na)
C8H11N
C6H5NO3
C6H4NNaO2
121.18
104-90-5
–
1 year
–70.9°C
178.3°C
0.918–0.921
–
iron drum 180 kg
not restricted
139.11
5006-66-6
97.5–100.3 %
2–3 years
314 –316°C
–
–
–
drums
not restricted
14
145.09
54-86-4
99.0–100.3 %
3 years
410°C
–
–
–
drums
not restricted
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Niacin min. 99.5 % (NS fg)
Niacinamide USP (NSA USP)
Meta™ metaldehyde (META tc)
C6H5NO2
C6H6N2O
C8H16O4
123.11
59-67-6
99.5–100.3 %
3 years
234.0–237.0°C
–
–
–
paper bags, big bags
not restricted
122.13
98-92-0
99.0–101.0 %
3 years
128.0–131.0°C
–
–
–
bag-in-box 20 kg
not restricted
176.21
108-62-3
98.0–99.8 %
3 years (10°C)
246°C
–
–
–
bag-in-box 25 kg
not restricted
Paraldehyde (PARA)
2-Picoline (Picoline,2)
4-Picoline (Picoline,4)
C6H12O3
C6H7N
C5H7N
132.16
123-63-7
99.5 %
60 days
–
–
0.993–0.997 kg/l (20°C)
–
iron drum 200 kg, bulk
not restricted
93.13
109-06-8
99.0 %
2 years
–66.8°C
125–130°C
–
–
iron drum 180 kg, bulk
not restricted
Pyrimidine (<0.5 % water)
4,6-Dimethoxy-2-[(phenoxycarbonyl)amino]pyrimidine
(Pyrimidine W<0.5)
(ADMP-carbamat)
C4H4N2
C13H13N3O4
93.13
108-89-4
>98.0 %
–
3.6°C
145.4°C
0.954
T toxic; R10, R20/22, R24, R36/37/38
–
not restricted
Pharma
Colorants
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
80.09
289-95-2
98.5–100.0 %
2 years
20–22°C
122–24°C
1.016
–
drums
not restricted
275.26
89392-03-0
97.0–101.0 %
2 years
120–122°C
> 250°C
–
–
drums
not restricted
15
Agriculture
Polymers
Nutrition
Various
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Acetaldehyde (AcAl)
Acetic acid (glacial) (ES 99)
Acetic anhydride (ESanhydrid)
Basic
chemicals
C2H4O
C2H4O2
C4H6O3
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
44.05
75-07-0
99.5 %
1 year
–123.5°C
21°C
0.784–0.786 kg/l (15°C)
–
drums, bulk
not restricted
60.05
64-19-7
99.5–100.0 %
2 years
15.8–16.3°C
113–115°C / 933 hPa
1.050 g/ml (20°C)
–
drum 200 kg, bulk
not restricted
102.09
108-24-7
99.5 %
2 years
–73°C
–
1.0820
–
drums 200 kg, rail tanker
not restricted
Ammonia techn. (Ammonia tc)
Ammonia aqueous (Ammonia 24)
approx. 24.5–24.9 % chemically pure
Nitric acid 65 %
NH3
NH3
HNO3
17.03
7664-41-7
99.8 %
2 years
–
33.4°C / 1013 hPa
0.609
–
rail tanker
not restricted
17.03
1336-21-6
24.5–24.9 %
2 years
–
–
0.9150–0.9110 g/ml (15°C)
–
drums, road and rail tanker
not restricted
Nitrosylsulfuric acid 40 % (SS,Nitrosyl 40)
Malonic acid (MA)
HNO5S
C3H4O4
127.08
7782-78-7
39.5–40.5 %
2 years
–12 – –3°C
333°C
1.893
–
rail tanker
not restricted
104.06
141-82-2
99 %
1 year
134°C (Mettler)
–
–
Xi irritant; R36
bags
not restricted
16
63.01
7697-37-2
65.0–65.5 %
–
–33°C
121°C / 1013 hPa
–
–
rail tanker
not restricted
Others
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
2,6-Diethyl-4-methylaniline (DEMA)
2,6-Diisopropylaniline (DIPA)
4,4-Dimethoxy-butan-2-one (DMB)
C11H17N
C12H19N
C6H12O3
163.26
24544-08-9
>98.0 %
1 year
–12°C – –7°C
–
0.945
Xn harmful; R21/22
steel drums, bulk
not restricted
177.29
24544-04-5
92.0 %
1 year
–45°C
257°C / 1013 mbar
0.940
R52/53
iron drum 180 kg, bulk
not restricted
132.16
5436-21-5
>92.0 %
2 years
–83 – –81°C
169–71°C
0.9977
–
drums, bulk
not restricted
Valeronitrile (VN)
C5H9N
Pharma
Colorants
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Agriculture
83.13
110-59-8
99.5 %
2 years
–
139–141°C / 1013 hPa
0.7990
–
drums, bulk
not restricted
Polymers
Nutrition
Various
17
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Alphabetical index
Page Product
A
6
1
16
16
9
7
8
8
7
8
8
7
10
12
14
14
14
13
14
13
16
10
Acetaldehyde Acetic acid (glacial) Acetic anhydride Acetoacetamide
Acetoacetanilide
Acetoacet-4-chloro-2,5-dimethoxyanilide
Acetoacet-5-chloro-2-methoxyanilide
Acetoacet-m-xylidide
Acetoacet-o-anisidide Acetoacet-o-chloroanilide Acetoacet-o-toluidide 2-(Acetoacetoxy)ethyl methacrylate
Adenine
Akolidine 10
Akolidine 11
Akolidine 12
Allyl cyanoacetate 2-Amino-4,6-dimethoxypyrimidine
3-Aminocrotononitrile Ammonia aqueous approx. 24.5–24.9 % chemically pure Ammonia techn.
B
6
6
13
6
11
Benzyl acetoacetate N-Benzyl-N-methyl-2-aminoethylacetoacetate
Butyl cyanoacetate t-Butyl cyanoacetate
1,4-Butyleneglycolbis(3-aminocrotonate)
C
4
1
13
12
12
2-Chloro-4,6-dimethoxypyrimidine Chlorosulfonyl isocyanate Cyanuric chloride A
Cyanuric chloride AS
Abbreviation
Page Product
D
AcAl
ES 99
ESanhydrid
AAamid
AAA
ASIRG
AAMOC
AAMX
AAOA
AAOC
AAOT
AAEMA
Adenine
Akolidine 10
Akolidine 11
Akolidine 12
CNESallyl
ADMP
Diacetonitril
Ammonia 24
Ammonia tc
9
9
9
11
11
10
10
10
8
10
16
11
16
16
15
8
11
9
6
Dehydroacetic acid
Dehydroacetic acid sodium salt monohydrate
Dehydroacetic acid sodium salt Diacetoacet-2-chloro-5-methyl-1,4-phenylenediamide
Diacetoacet-2,5-dichloro-1,4-phenylenediamide
Diacetoacet-2,5-dimethyl-1,4-phenylenediamide
Diacetoacet-1,4-phenylenediamide
Diacetoacet-o-tolidide N,N-Diethylacetoacetamide Diethyl squarate
2,6-Diethyl-4-methylaniline Diketene-acetone adduct
2,6-Diisopropylaniline 4,4-Dimethoxy-butan-2-one 4,6-Dimethoxy-2-[(phenoxy-carbonyl)amino]pyrimidine
N,N-Dimethylacetoacetamide 2,5-Dimethyl-2,4-dihydro-pyrazol-3-on 3,5-Dimethylpyrazole
Dodecyl acetoacetate
DHS
NaDHS-H2O
NaDHS
DiAA MC
DiAA DC
DiAA DM
DiAAphen
DiAA-o-tolidid
DEAA
QS, diethyl
DEMA
DAA
DIPA
DMB
(ADMP-carbamat)
DMAA
DMPO
DMP
AAdodecyl
6
7
11
14
14
12
E
Ethyl acetoacetate
Ethyl benzoylacetate Ethyl 4-chloroacetoacetate
5-Ethyl-2-methylpyridine 2-(5-Ethyl-2-pyridyl)ethanol Ethyl 4,4,4-trifluoroacetoacetate
EAA
BESethyl
CAAEt
MEP
PRD-2-etol, 5-Et
ETFAA
H
14
6-Hydroxynicotinic acid NS,6-Hydroxy
6
6
I
Isobutyl acetoacetate
Isopropyl acetoacetate AAisobutyl
IPAA
M
6
1
13
13
15
7
13
9
12
11
12
12
8
6
Malonic acid Malononitrile (85 % in methanol) Malononitrile Meta™ metaldehyde 2-Methoxyethyl acetoacetate 2-Methoxyethyl cyanoacetate 3-Methyl-5-pyrazolone Methyl 3,3-dimethoxypropanoate
Methyl 3-aminocrotonate
(E)-Methyl 3-methoxyacrylate Methyl 4-methyl-3-oxopentanoate N-Methylacetoacetamide Methyl acetoacetate BAA
AABME
CNESbutyl
AA-t-butyl
BGAC
DMP, 2-Chlor
CSI
CC A
CC AS
18
Abbreviation
MA
MDN
MDN
META tc
AAmethoxyethyl
CNES methoxyet
MP
PRSMe,DM
ACMe
E-MMA
OPMe, 4-methyl
MMAA
MAA
Page Product
Abbreviation
N
5
1
15
16
7
16
Niacin min. 99.5 % Niacinamide USP Nitric acid 65 %
4-Nitrobenzyl acetoacetate (30 % in toluene)
Nitrosylsulfuric acid 40 % P
Paraldehyde 2-Picoline
4-Picoline
Potassium N-(acetoacetyl)sulfanilate
Propane-1,1,1-triyltrimethyl tris(acetoacetate)
Pyrimidine (<0.5 % water)
PARA
Picoine,2
Picoline,4
AAsulfanil-K
AATMP
Pyrimidine W<0.5
S
Sodium dicyanamide Sodium nicotinate Squaric acid Na-dicyanamide
NS-Na
QS
T
1,1,3,3-Tetramethylguanidine Thiodiglycolbis(3-aminocrotonate)
TMG
TGAC
V
Valeronitrile
VN
5
1
15
15
8
10
15
3
1
14
10
3
1
11
16
NS fg
NSA USP
PNBAA 30T
SS,Nitrosyl 40
www.lonza.com
Administration /
technical service
Sales offices
Switzerland
Europe
Asia
Lonza Ltd
Muenchensteinerstrasse 38
4002 Basel
Tel + 41 61 316 81 11
contact@lonza.com
Lonza Benelux BV
Aluminiumstraat 1
PO Box 3148
NL-4823 AL Breda
Tel +31 76 542 51 00
contact.nl@lonza.com
Lonza Guangzhou Ltd
39, Jinhui Road
Haizhu District
CN-Guangzhou 510288
Tel +86 20 8433 8998
contact.cn@lonza.com
Lonza Biotec sro
Okruzní 134
CZ-281 61 Kouřím
Tel +42 0321 738 654
contact.cz@lonza.com
Lonza Japan Ltd
Kyowa Shinkawa Bldg 8F
2-20-8, Shinkawa, Chuo-ku
JP-Tokyo 104-0033
Tel +81 3 5566 0612
contact.jp@lonza.com
USA
Lonza Inc.
90 Boroline Road
Allendale, NJ 07401
Tel +1 201 316 9200
contact.allendale@lonza.com
Lonza France Sàrl
55, rue Aristide Briand
FR-92309 Levallois-Perret Cedex
Tel +33 1 40 89 99 00
contact.fr@lonza.com
Lonza Cologne GmbH
Nattermannallee 1
DE-50829 Köln
Tel + 49 221 99 1990
info.cologne@lonza.com
Lonza Ltd Representation Office
Dunaház III. lépcsöház II. em 2
Boráros tér 7
HU-1095 Budapest IX
Tel +36 1 215 94 19
contact.hu@lonza.com
Lonza Ltd Representation Office
ul. Smolenskiego 4 m 15
PL-01-698 Warsaw
Tel +48 22 833 87 45
contact.pl@lonza.com
Lonza Ibérica S.A.U. (Unipersonal)
Vía Augusta, n° 18, 2a Pta, izda
ES-08006 Barcelona
Tel +34 93 238 54 60
contact.es@lonza.com
Lonza Biologics plc
Suite 3, Building A
The Courtyard
Severn Drive
Tewkesbury Business Park
GB-Tewkesbury GL20 8GD
Tel +44 1684 292 728
contact.uk@lonza.com
The information contained herein is believed to be correct
and corresponds to the latest state of scientific and technical
knowledge. However, no warranty is made, either expressed
or implied, regarding its accuracy or the results to be obtained
from the use of such information. Some products may not be
available in all markets or for every type of application. Any
user must make his own determination and satisfy himself
that the products supplied by Lonza Group Ltd and the information and recommendations given by Lonza Group Ltd are (i)
suitable for intended process or purpose, (ii) in compliance
with environmental, health and safety regulations, and (iii)
will not infringe any third party’s intellectual property rights.
© 2011 Lonza Ltd