Osteoporose

Transcription

Osteoporose

Thomas Klein
Raimund von Helden
Osteoporose
als Folge fehlerhafter Ernährung und Lebensweise
Über die Irrtümer der Osteoporose-Medizin
und die Kunst, gesund zu bleiben
Vitamin C, D, E, K1 und K2 , Magnesium,
Spurenelemente, Antioxidantien, Säure-Basen-Haushalt,
die Gefahr der Kalzium- und Phosphatüberlastung,
die richtigen Grundnährstoffe,
Bewegung, Sport und Krafttraining
Hygeia-Verlag
Thomas Klein, Raimund von Helden:
Osteoporose als Folge fehlerhafter Ernährung und Lebensweise.
Hygeia-Verlag Dresden 2016.
(Literaturverzeichnis, Auszug aus dem Buch)
Haftungsausschluß
Dieses Buch wurde sorgfältig erarbeitet. Dennoch übernehmen Autoren und Verlag
keinerlei Haftung für die Richtigkeit von Angaben und Empfehlungen sowie für
eventuelle Druckfehler. Bei Beschwerden und Erkrankungen ist unbedingt ärztlicher Rat
einzuholen.
Bibliografische Informationen sind bei der Deutschen Bibliothek
im Internet unter www.dnb.de abrufbar.
Thom as K lei n , R a i m u n d von H elden :
Über die Irrtümer der Osteoporose-Medizin
und die Kunst, gesund zu bleiben.
Hygeia-Verlag Dresden 2016
Nachdruck verboten!
Alle Rechte vorbehalten, besonders das Recht
der Übersetzung in fremde Sprachen, der Kopie
und der Aufnahme in Dateien und Datenbanken.
Copyright © Thomas Klein 2016
ISBN 978-3-939865-14-8
www.hygeia.de
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Andere Spurenelemente
Spurenelemente allgemein
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B oon en ; B lack et al.: Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with
osteoporosis aged 75 and older. J Am Geriatr Soc. 2010;58(2):292-9.
C u m m i ngs ; B lack ; Thom pson et al.: Effect of alendronate on risk of fracture in
women with low bone density but without vertebral fractures: results from the
Fracture Intervention Trial. JAMA. 1998;280(24):2077-82.
E rv i t i ; A lonso; G orr icho; L ópez : Oral bisphosphonates may not decrease hip
fracture risk in elderly Spanish women. BMJ. 2013a;3(2).
H a rr is ; Watts ; G ena n t et al.: Effects of risedronate treatment on vertebral and
nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT)
Study Group. JAMA. 1999;282(14):1344-52.
H osk i ng ; C h i lv er s ; C h r ist i a nsen et al.: Prevention of bone loss with alendronate in postmenopausal women under 60 years of age. Early Postmenopausal
Intervention Cohort Study Group. N Engl J Med. 1998 ;338(8):485-92.
Jä rv i n e n ; M ich a ëlsson ; A spen berg ; S i evä n en : Osteoporosis: the emperor
has no clothes. J Intern Med. 2015 Jun;277(6):662-73.
K a n is ; Ba rton ; J oh n ell : Risedronate decreases fracture risk in patients selected
solely on the basis of prior vertebral fracture.
L e B la nc ; R osa les ; Ba lasu br a m a n i a n et al.: Risk factors for fracture among
current, persistent users of bisphosphonates. Osteoporos Int. 2015;26(2):713-25.
Ly les ; C olón -E m er ic ; M aga z i n er et al.: Zoledronic acid and clinical fractures
and mortality after hip fracture. N Engl J Med. 2007;357(18):1799-809.
M c C lu ng ; G eusens ; M i ller et al.: Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group.
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M i ller : Non-vertebral fracture risk reduction with oral bisphosphonates:
challenges with interpreting clinical trial data.
Curr Med Res Opin. 2008;24(1):107-19.
O rwoll ; M i ller ; A dach i et al.: Efficacy and safety of a once-yearly i.v. Infusion of zoledronic acid 5 mg versus a once-weekly 70-mg oral alendronate in
the treatment of male osteoporosis: a randomized, multicenter, double-blind,
active-controlled study. J Bone Miner Res. 2010 Oct;25(10):2239-50.
R i nge ; Fa r a h m a n d; Fa ber ; D or st : Sustained efficacy of risedronate in men
with primary and secondary osteoporosis: results of a 2-year study.
Rheumatol Int. 2009;29(3):311-5.
S err a no; B eg oña ; A n i t ua et al.: Systematic review and meta-analysis of the
efficacy and safety of alendronate and zoledronate for the treatment of postmenopausal osteoporosis. Gynecol Endocrinol. 2013;29(12):1005-14.
Wells ; C r a n n ey ; P et er son et al.: Alendronate for the primary and secondary
prevention of osteoporotic fractures in postmenopausal women.
Cochrane Database Syst Rev. 2008 Jan 23;(1):CD001155.
Wells ; C r a n n ey ; P et er son et al.: Risedronate for the primary and secondary
prevention of osteoporotic fractures in postmenopausal women.
Cochrane Database Syst Rev. 2008a Jan 23;(1):CD004523.
Schädigung der Schleimhäute des Verdauungstraktes
G r een ; C z a n n er ; R eev es et al.: Oral bisphosphonates and risk of cancer of
oesophagus, stomach, and colorectum: case-control analysis within a UK
primary care cohort. BMJ. 2010;341:c4444.
K nopp -S i hota ; C u m m i ngs ; H om i k ; Voa k la n der : The association between
serious upper gastrointestinal bleeding and incident bisphosphonate use: a
population-based nested cohort study. BMC Geriatr. 2013;13:36.
Pa pa petrou : Bisphosphonate-associated adverse events. Hormones (Athens).
2009;8(2):96-110.
S h a h een : More on reports of esophageal cancer with oral bisphosphonate use.
N Engl J Med. 2009;360(17):1790-1.
S i r is ; O st er ; B i lez i k i a n : More on reports of esophageal cancer with oral
bisphosphonate use. N Engl J Med. 2009;360(17):1791.
W ysowsk i : Oral bisphosphonates and oesophageal cancer.
BMJ. 2010 Sep 1;341:c4506.
W ysowsk i : Reports of esophageal cancer with oral bisphosphonate use.
N Engl J Med. 2009;360(1):89-90.
Entzündungen
A da m i ; B h a lla ; D or i zz i et al.: The acute-phase response after bisphosphonate
administration. Calcif Tissue Int. 1987 Dec;41(6):326-31.
Ba daya n ; C u dkow icz : Profound muscle weakness and pain after one dose of
actonel. Case Rep Med. 2009:693014.
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C a da r io: Alendronate: suspected pancreatitis. CMAJ. 2002;166(1):86-7, 91-2.
C a rr èr e ; D u va l ; G oda r d et al.: Severe acute hepatitis induced by alendronate.
Gastroenterol Clin Biol. 2002 Feb;26(2):179-80.
D i a z -B orjon ; S ey ler ; C h en ; L i m : Bisphosphonate-associated arthritis.
J Clin Rheumatol. 2006 Jun;12(3):131-3.
E n do; N a k a m u r a ; K i kuch i et al.: Aminoalkylbisphosphonates, potent inhibitors
of bone resorption, induce a prolonged stimulation of histamine synthesis and
increase macrophages, granulocytes, and osteoclasts in vivo.
Et m i na n ; Foroogh i a n ; M a ber ley : Inflammatory ocular adverse events with
the use of oral bisphosphonates: a retrospective cohort study.
CMAJ. 2012 May 15;184(8):E431-4.
F r au n felder ; F r au n felder : Bisphosphonates and ocular inflammation.
N Engl J Med. 2003 Mar 20;348(12):1187-8.
F r e nch ; M a rg o: Postmarketing surveillance rates of uveitis and scleritis with
bisphosphonates among a national veteran cohort. Retina. 2008;28(6):889-93.
G er st er : Acute polyarthritis related to once-weekly alendronate in a woman with
osteoporosis. J Rheumatol. 2004;31(4):829-30.
H a la be ; L i fsch i tz ; A z u r i : Liver damage due to alendronate.
N Engl J Med. 2000 Aug 3;343(5):365-6.
H ew i tt ; L issi na ; G r een et al.: The bisphosphonate acute phase response: rapid
and copious production of proinflammatory cytokines by peripheral blood gd T
cells in response to aminobisphosphonates is inhibited by statins.
Clin Exp Immunol. 2005 Jan;139(1):101-11.
K i ya m a ; O k a da ; Ta na k a et al.: Inflammatory and necrotic effects of minodronate, a nitrogen-containing bisphosphonate, in mice. Tohoku J Exp Med.
2013;230(3):141-9.
L i ev er se : Hepatitis after alendronate. Neth J Med. 1998;53(6):271-2.
L i m ; Kwon ; Pa rk ; Pa rk : Acute effects of intravenous administration of pamidronate in patients with osteoporosis. J Korean Med Sci. 2010;25(9):1277-83.
M c K agu e ; J orgenson ; B u xton : Ocular side effects of bisphosphonates: A case
report and literature review. Can Fam Physician. 2010;56(10):1015-7.
M u r atsu ; Yosh iga ; Ta k etom i et al.: Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of
SOCS1 in macrophages. PLoS One. 2013 Jul 9;8(7):e67906.
O r ; C u i ; M atsu ba r a ; Foroogh i a n : Pro-inflammatory and anti-angiogenic
effects of bisphosphonates on human cultured retinal pigment epithelial cells.
Br J Ophthalmol. 2013 Aug;97(8):1074-8.
P rom m er : Toxicity of bisphosphonates. J Palliat Med. 2009 Nov;12(11):1061-5.
S a lm en , B erru eta ; S á nch ez et al.: Nongranulomatous anterior uveitis associated with alendronate therapy. Invest Clin. 2002;43(1):49-52.
S au t y ; P ech er stor fer ; Z i m m er -R ot h et al.: Interleukin-6 and tumor necrosis
factor alpha levels after bisphosphonates treatment in vitro and in patients with
malignancy. Bone. 1996;18(2):133-9.
746
S ch eller ; H a n k enson ; R eu ben ; K r ebsbach : Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. J Cell Biochem.
2011;112(11):3364-72.
S ch w ei tz er ; O ost en dorp -va n de R u i t ; Va n der P lu i j m et al.: Interleukin-6
and the acute phase response during treatment of patients with Paget‘s disease
with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. J Bone Miner Res. 1995 Jun;10(6):956-62.
Toussi rot ; Vu i tton ; K och ; Va ln et -R a bi er : Acute pancreatitis occurring after
pamidronate infusions in two patients with spondyloarthritis.
Case Rep Rheumatol. 2013:912692.
Weber ; O la i wa n ; B on t e et al.: Adverse cutaneous drug reactions to ibandronate.
Eur J Dermatol. 2011 Jul-Aug;21(4):591-4.
W ysowsk i ; C h a ng: Alendronate and risedronate: reports of severe bone, joint,
and muscle pain. Arch Intern Med. 2005;165(3):346-7.
Ya m aguch i ; M ot egi ; I wa ku r a ; E n do: Involvement of interleukin-1 in the
inflammatory actions of aminobisphosphonates in mice.
Br J Pharmacol. 2000;130(7):1646-54.
Ya n i k ; Tu rk ay ; A ta la r : Hepatotoxicity induced by alendronate therapy.
Osteoporos Int. 2007 Jun;18(6):829-31.
Schwächung der Abwehrkraft
K u i per ; For st er ; S u n et al.: Zoledronate and pamidronate depress neutrophil
functions and survival in mice. Br. J. Pharmacol. 2012;165(2):532-9.
R eu be n ; D i n h ; L ee et al.: Bisphosphonates inhibit phosphorylation of signal
transducer and activator of transcription 3 and expression of suppressor of
cytokine signaling 3: implications for their effects on innate immune function
and osteoclastogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2011;111(2):196-204.
Nierenschäden
H i r sch berg: Renal complications from bisphosphonate treatment.
Curr Opin Support Palliat Care. 2012 Sep;6(3):342-7.
K om a da ; M or ish i ta ; K i ta m u r a et al.: Acute kidney injury in a patient with
nephrotic syndrome due to focal segmental glomerular nephritis induced by a
single oral administration of high-dose bisphosphonate (minodronate).
Intern Med. 2013;52(12):1383-7.
M i u r a ; M i z u no; A oya m a et al.: Massive proteinuria and acute renal failure
after oral bisphosphonate (alendronate) administration in a patient with focal
segmental glomerulosclerosis. Clin Exp Nephrol. 2009 Feb;13(1):85-8.
Yi lm a z ; Ta n i n m is ; K a r a et al.: Nephrotic syndrome after oral bisphosphonate
(alendronate) administration in a patient with osteoporosis. Osteoporos Int.
2012;23(7):2059-62.
747
Abfall des Kalziumspiegels
D o; Pa rk ; Pa rk et al.: Bisphosphonate-induced Severe Hypocalcemia A Case Report. J Bone Metab. 2012 Nov;19(2):139-45.
N asi ru ddi n ; Faya z u ddi n ; Z a h i d; I ft ek h a r : Acute delirium in an elderly
woman following zoledronate administration.
J Pharmacol Pharmacother. 2014;5(3):217-9.
S ch ussh ei m ; Jacobs ; S i lv er berg: Hypocalcemia associated with alendronate.
Ann Intern Med. 1999;130(4 Pt 1):329.
Störung der Herzfunktion
B h u r i ya ; S i ngh ; M olna r et al.: Bisphosphonate use in women and the risk
of atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol.
2010;142(3):213-7.
H eck bert ; L i ; C u m m i ngs et al.: Use of alendronate and risk of incident atrial
fibrillation in women. Arch Intern Med. 2008;168(8):826-31.
L ok e ; J eeva na n t h a m ; S i ngh : Bisphosphonates and atrial fibrillation: systematic
review and meta-analysis. Drug Saf. 2009;32(3):219-28.
M aclsa ac ; S eem a n ; J eru ms : Seizures after alendronate.
J R Soc Med. 2002;95(12):615-6.
S h i msh i ; A be ; F ish er et al.: Bisphosphonates induce inflammation and rupture
of atherosclerotic plaques in apolipoprotein-E null mice.
Tsa i ; H ua ng ; C h a ng et al.: Zoledronate inhibits ischemia-induced neovascularization by impairing the mobilization and function of endothelial progenitor
cells. PLoS One. 2012;7(7):e41065.
Verschlechterung des Q10-Status
K a lya n ; H u ebbe ; E sat beyoglu et al.: Nitrogen-bisphosphonate therapy is
linked to compromised coenzyme Q10 and vitamin E status in postmenopausal
women. J Clin Endocrinol Metab. 2014;99(4):1307-13.
Denosumab – schlimmer als Bisphosphonate
B on e ; C h a pu r lat ; B r a n di et al.: The effect of three or six years of denosumab
exposure in women with postmenopausal osteoporosis: results from the FREEDOM extension. J Clin Endocrinol Metab. 2013 Nov;98(11):4483-92.
B r i dgem a n ; Pat h a k : Denosumab for the reduction of bone loss in postmenopausal osteoporosis: a review. Clin Ther. 2011 Nov;33(11):1547-59.
C u m m i ngs ; S a n M a rt i n ; M c C lu ng et al.: Denosumab for prevention of fractures
in postmenopausal women with osteoporosis. N Engl J Med. 2009;361(8):756-65.
748
D el Fattor e ; Tet i : The tight relationship between osteoclasts and the immune
system. Inflamm Allergy Drug Targets. 2012;11(3):181-7.
M a kr as ; P olyzos ; Pa pat h eodorou et al.: Parathyroid hormone changes following denosumab treatment in postmenopausal osteoporosis. Clin Endocrinol
(Oxf). 2013;79(4):499-503.
M c C lu ng ; B oon en ; Törr i ng et al.: Effect of denosumab treatment on the risk
of fractures in subgroups of women with postmenopausal osteoporosis.
J Bone Miner Res. 2012;27(1):211-8.
M osa li ; B er na r d; Wa j ed et al.: Vitamin D status and parathyroid hormone
concentrations influence the skeletal response to zoledronate and denosumab.
R ei d; C or n ish : Epidemiology and pathogenesis of osteonecrosis of the jaw.
Nat Rev Rheumatol. 2011;8(2):90-6.
von K eyser li ngk ; H opk i ns ; A nastasi la k is et al.: Clinical efficacy and safety
of denosumab in postmenopausal women with low bone mineral density and
osteoporosis: a meta-analysis. Semin Arthritis Rheum. 2011 Oct;41(2):178-86.
Watts ; R ou x ; M odli n et al.: Infections in postmenopausal women with osteoporosis treated with denosumab or placebo: coincidence or causal association?
Die Wahrheit über Teriparatid
B u n ya r atav ej : Experience of application: blood screening and bone turnover
markers for prevention of unwanted effects and early outcomes of teriparatide.
J Med Assoc Thai. 2011 Oct;94 Suppl 5:S31-4.
G a llagh er ; G ena n t ; C r a ns et al.: Teriparatide reduces the fracture risk associated with increasing number and severity of osteoporotic fractures.
G r eenspa n ; B on e et al.: Effect of recombinant human parathyroid hormone (184) on vertebral fracture and bone mineral density in postmenopausal women
with osteoporosis: a randomized trial. Ann Intern Med. 2007;146(5):326-39.
H a j i m e ; O k a da ; M or i ; Ta na k a : A case of teriparatide-induced severe hypophosphatemia and hypercalcemia. J Bone Miner Metab. 2014 Sep;32(5):601-4.
H odsm a n ; Bau er ; D em pst er et al.: Parathyroid hormone and teriparatide for the
treatment of osteoporosis: a review of the evidence and suggested guidelines
for its use. Endocr Rev. 2005 Aug;26(5):688-703.
J i a ng ; Z h ao; M i t la k et al.: Recombinant human parathyroid hormone (1-34)
[teriparatide] improves both cortical and cancellous bone structure.
J Bone Miner Res. 2003;18(11):1932-41.
749
K a r atopr a k ; K ayatas ; K i licasla n et et al.: Severe hypercalcemia due to
teriparatide. Indian J Pharmacol. 2012;44(2):270-271.
L asco; C ata la no; M or a bi to et al.: Adrenal effects of teriparatide in the treatment of severe postmenopausal osteoporosis. Osteoporos Int. 2011;22(1):299-303.
L i n dsay ; N i ev es ; For m ica et al.: Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet. 1997;350(9077):550-5.
M a rcus : Present at the beginning: a personal reminiscence on the history
of teriparatide. Osteoporos Int. 2011;22(8):2241-8.
M a rcus ; Wa ng ; S att erw h i t e ; M i t la k : The skeletal response to teriparatide is
largely independent of age, initial bone mineral density, and prevalent vertebral fractures in postmenopausal women with osteoporosis. J Bone Miner Res.
2003;18(1):18-23.
N eer ; A r nau d; Z a nch etta et al.: Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.
N Engl J Med. 2001;344(19):1434-41.
Th i ruch elva m ; R a n dh awa ; S a di ek ; K ista nga r i : Teriparatide induced delayed
persistent hypercalcemia. Case Rep Endocrinol. 2014:802473.
Vorsicht mit Strontium!
A br a h a mse n ; G rov e ; Vest erga a r d: Nationwide registry-based analysis of
cardiovascular risk factors and adverse outcomes in patients treated with strontium ranelate. Osteoporos Int. 2014;25(2):757-62.
Bä r en holdt ; K olt hof f ; N i elsen : Effect of long-term treatment with strontium
ranelate on bone strontium content. Bone. 2009;45(2):200-6.
B oi v i n ; D ou bli er ; Fa r lay : Strontium ranelate--a promising therapeutic principle in osteoporosis. J Trace Elem Med Biol. 2012 Jun;26(2-3):153-6.
B oi v i n ; Fa r lay ; K h ebba b et al.: In osteoporotic women treated with strontium
ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Osteoporos Int. 2010;21(4):667-77.
B oi v i n ; M eu n i er : The mineralization of bone tissue: a forgotten dimension in
osteoporosis research. Osteoporos Int. 2003;14 Suppl 3:S19-24.
B on n ely e ; C h a ba del ; S a lt el ; J u r dic : Dual effect of strontium ranelate:
stimulation of osteoblast differentiation and inhibition of osteoclast formation
and resorption in vitro. Bone. 2008;42(1):129-38.
C i a n ferott i ; D‘A sta ; B r a n di : A review on strontium ranelate long-term
antifracture efficacy in the treatment of postmenopausal osteoporosis.
Ther Adv Musculoskelet Dis. 2013;5(3):127-39.
C ollett e ; B ru y èr e ; K au f m a n et al.: Vertebral anti-fracture efficacy
of strontium ranelate according to pre-treatment bone turnover.
Osteoporos Int. 2010;21(2):233-41.
750
Fonseca ; B r a n di : Mechanism of action of strontium ranelate: what are the facts?
Clin Cases Miner Bone Metab. 2010;7(1):17-8.
K a n is ; J oh a nsson ; O den ; M c C losk ey : A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX(®).
Osteoporos Int. 2011;22(8):2347-55.
L i ; P e ng ; Pa n et al.: Microarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goats.
Biol Trace Elem Res. 2012;145(1):39-46.
M a ; Z h a ng ; W u et al.: Strontium fructose 1,6-diphosphate prevents bone loss
in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK
pathway. Acta Pharmacol Sin. 2012 Apr;33(4):479-89.
M a r i e : Strontium ranelate: a dual mode of action rebalancing bone turnover in
favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.
M a r i e : Strontium ranelate: a novel mode of action optimizing bone formation and
resorption. Osteoporos Int. 2005;16 Suppl 1:S7-10.
M eu n i er ; R ou x ; O rtola n i et al.: Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis.
Osteoporos Int. 2009;20(10):1663-73.
M eu n i er ; R ou x ; S eem a n et al.: The effects of strontium ranelate on the risk of
vertebral fracture in women with postmenopausal osteoporosis.
N Engl J Med. 2004;350(5):459-68.
M on tagna n i : Bone anabolics in osteoporosis: Actuality and perspectives.
World J Orthop. 2014;5(3):247-54.
O‘D on n ell ; C r a n n ey ; Wells et al.: Strontium ranelate for preventing and treating
postmenopausal osteoporosis. Cochrane Database Syst Rev. 2006;(3):CD005326.
O sbor n e ; L ay ton ; P err io et al.: Incidence of venous thromboembolism in users
of strontium ranelate: an analysis of data from a prescription-event monitoring
study in England. Drug Saf. 2010;33(7):579-91.
P e ng ; L i u ; H ua ng et al.: The cross-talk between osteoclasts and osteoblasts
in response to strontium treatment: involvement of osteoprotegerin. Bone.
2011;49(6):1290-8.
R egi nst er ; K au f m a n ; G oem a er e et al.: Maintenance of antifracture efficacy
over 10 years with strontium ranelate in postmenopausal osteoporosis.
Osteoporos Int. 2012;23(3):1115-22.
R egi nst er ; H i ligsm a n n ; B ru y er e : Strontium Ranelate: Long-Term Efficacy
against Vertebral, Nonvertebral and Hip Fractures in Patients with Postmenopausal Osteoporosis. Ther Adv Musculoskelet Dis. 2010;2(3):133-43.
R egi nst er ; F elsen berg ; B oon en et al.: Effects of long-term strontium ranelate
treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial.
Arthritis Rheum. 2008 Jun;58(6):1687-95.
R egi nst er ; D eroisy et al.: Prevention of early postmenopausal bone loss by
strontium ranelate: the randomized, two-year, double-masked, dose-ranging,
placebo-controlled PREVOS trial. Osteoporos Int. 2002;13(12):925-31.
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and risk of vertebral fractures in frail osteoporotic women.
Bone. 2011;48(2):332-8.
R ou x ; F ech t e n bau m ; K olta et al.: Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis.
Ann Rheum Dis. 2008;67(12):1736-8.
S eem a n ; D evogela er ; L or enc et al.: Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. J Bone Miner Res. 2008;23(3):433-8.
Ta n ; Z h a ng ; Z h u et al.: Deregulation of bone forming cells in bone diseases and
anabolic effects of strontium-containing agents and biomaterials.
Biomed Res Int. 2014:814057.
The TReatment Of Peripheral OSteoporosis (TROPOS).
Kombinationstherapie – die Alternative
G e n u is ; B ouch a r d: Combination of Micronutrients for Bone (COMB) Study: bone
density after micronutrient intervention. J Environ Public Health. 2012:354151.
Überlastung mit Strontium
Bau m a n ; Va li n i etse ; Ba ba ry k i n : Effect of strontium on the anti-rickets activity of vitamin D3 and its hydroxy analogs. Vopr Med Khim. 1988;34(4):26-32.
C oh e n -S ola l : Strontium overload and toxicity: impact on renal osteodystrophy.
Nephrol Dial Transplant. 2002;17 Suppl 2:30-4. h
C orr a di no; E bel ; C r a ig et al.: Calcium absorption and the vitamin D 3dependent calcium-binding protein. I. Inhibition by dietary strontium.
Calcif Tissue Res. 1971;7(2):81-92.
K roes ; de n Ton k ela a r ; Minderhoud et al.: Short-term toxicity of strontium
chloride in rats. Toxicology. 1977;7(1):11-21.
N eu feld; B osk ey : Strontium alters the complexed acidic phospholipid content of
mineralizing tissues. Bone. 1994 Jul-Aug;15(4):425-30.
O m da h l ; J eli n ek ; E aton : Kinetic analysis of 25-hydroxyvitamin D3
metabolism in strontium-induced rickets in the chick.
J Clin Invest. 1977 Nov;60(5):1202-10.
O m da h l ; D e L uca : Rachitogenic activity of dietary strontium. I. Inhibition of
intestinal calcium absorption and 1,25-dihydroxycholecalciferol synthesis.
J Biol Chem. 1972;247(17):5520-6.
O m da h l ; D e L uca : Strontium induced rickets: metabolic basis.
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O st e ; B ervoets ; B eh ets et al.: Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats. Kidney Int. 2005;67(3):920-30.
O zgü r ; S ü m er ; K oço ğlu : Rickets and soil strontium.
Arch Dis Child. 1996 Dec;75(6):524-6.
P etrova ; M i loser dova ; Ba bask i na : Toxic action of ergocalciferol in strontium
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P ola k-J uszcz a k : Impact of strontium on skeletal deformities in Baltic cod (Gadus morhua callaris L.). Chemosphere. 2011;83(4):486-91.
S ch root e n ; B eh ets ; C a br er a et al.: Dose-dependent effects of strontium on
bone of chronic renal failure rats. Kidney Int. 2003 Mar;63(3):927-35.
Wa dh wa ; C a r e : Effects of strontium on the absorption of calcium, magnesium and phosphate ions from the ovine reticulo-rumen. J Comp Physiol B.
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Wor n h a m ; H a jjaw i ; O rr iss ; A r n ett : Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of
osteoclasts in mouse marrow cultures. Osteoporos Int. 2014;25(10):2477-84.
Weitere Medikamente und Maßnahmen
Raloxifen
Ba rr ett -C on nor ; M osca ; C olli ns et al.: Effects of raloxifene
on cardiovascular events and breast cancer in postmenopausal women.
N Engl J Med. 2006;355(2):125-37.
Ett i nger ; B lack ; M i t la k et al.: Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a
3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation
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Mit Vibration gegen Osteoporose
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Andere Maßnahmen
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Die optimale Versorgung
mit Nährstoffen
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