New Technology

Looking to the Future
New Technologies & Advancements
Shannon Lin
Accredited Practising Dietitian
Credentialled Diabetes Educator
New Horizons
1. Monitors
2. Bolus calculators
3. Insulin delivery
4. Insulin pumps
Lets talk about……
Blood Glucose Testing
Lens Technology
Google’s smart contact lens: monitor BGLs
contained in human tears
• Patented by Google and partnered with
Novartis
1. Contact lens
2. Reader – sensor and chip & antenna
3. User Display/Device
Novartis hope to have full prototype by early
2015….STAY TUNED!
Saliva glucose meter
iQuickIt Saliva
Analyzer
• Non-invasive wick
• Single use strips
• Use a smart device
Clinical Trials happening in America now!
http://iquickitsalivaanalyzer.com/
In our backyard…
• Research led by Professor Dastoor at
University of Newcastle over last 8 years
• Saliva test “tabs” using 3D printing
• Watch this space…
Glucose Sensor “Tattoo”
• In advanced development
• Printed electrodes on
standard temporary tattoo
paper, paired with a
sensor
Currently not available in real time.
Team working on a user display.
Breath Sensors
• Measures amount of acetone in breath
• Requires exhaling into device
• According to the developers, “the portable device is
expected to provide a reading in five to seven
seconds, with the same accuracy tolerances as
present day glucometers, in a safe and pain-free
testing alternative.”
• Still under development
9
Finger-stick Free Device
A new product category: it
is between blood glucose
meters and CGMs
• Wear a sensor under
the skin
• The sensor patch to
reveal real-time glucose
values
• No alarm systems
Lets talk about……
Insulin
Bolus Insulin Calculators
• Integrated into BG meter
• Ability to advise mealtime insulin doses
• Programmed with insulin to carb ratios +
insulin sensitivities
• Commenced in conjunction with
endocrinologist + Diabetes Educator
Jet Stream ‘no needle’ Pens
InsuJet – Needle free
• Not pain-free
• Transition period may
require
• $275 with ongoing
consumables
Available in Australia now
through:
www.caresens.com.au
13
Inhalable Insulin
• Afrezza - uses a
whistle-sized
inhaler
• Rapid acting insulin
• Available in USA
from 4/2015
New Insulin Pump
• Medtronic MiniMed
640G
• Newest pump to
Australian market
• Predictive low
suspend feature
New Insulin Pump
• Insight is coming to
AUS next year!
• Full color display
• Easy navigate, zoom
function
• Accu-Chek FillAssist
Glucagon Delivery Devices
• In development/awaiting
approval
• Ready to inject glucagon
• Likely similar to Epi-Pen
• Also “mini dose”
Bionic Pancreas
• Experimental device
• Wearable device +
smartphone app paired with
pumps of insulin & glucagon
plus continuous glucose
monitor (CGM)
• Lots of clinical trials at present
Smart insulins in the pipeline
• “Smart” insulin can circulate in the
bloodstream >10 hours
• Responds rapidly to changes in BGLs
• Could eliminate need for repeated monitoring
& insulin injections throughout day
• When blood-glucose levels are high – glucose
binds to insulin & activates
• Once a day instead of long-acting insulin
Lets talk about……
Our own backyard
JDRF – not just working on a cure
JDRF have three arms of research:
1. Cure: Conducting outpatient studies of the
artificial pancreas (artificial pancrease
program)
2. Treat: Developing faster-acting insulin and
drugs to improve glucose control, including
glucose-responsive insulin
3. Prevent: Reducing the risk of developing T1Drelated complications
Australian Artificial Pancreas Program
 jointly developed by University of Newcastle
engineers and HMRI diabetes researchers
 Clinical trials for type 1 diabetics are now
planned for 2015 after an approved simulator
achieved encouraging results.
http://www.artificialpancreas.com.au/
Contacts for technology trends
• Glucose contact lens
http://diatribe.org/google-secures-patent-glucose-sensingcontact-lens
• FreeStyle libre
https://www.abbottdiabetescare.com/press-room/2014/2014e.html
• Saliva glucose meter
http://iquickitsalivaanalyzer.com
• Tattoo
http://ucsdnews.ucsd.edu/pressrelease/temporary_tattoo_off
ers_needle_free_way_to_monitor_glucose_levels
• Printed glucose paper
Carmen Swadling, Media and Public Relations. Ph 02 4921
5577.
Contact Email: media@newcastle.edu.au
• Insujet
www.caresens.com.au
• Medtonic pump
https://www.medtronic-diabetes.com.au/insulinpumps/640g
• Roche Insight Pump
https://www.accuchek.co.uk/gb/products/insulinpumps/insight.html
• Breath Sensor
http://nocamels.com/2012/02/new-diabetes-device-tomeasure-glucose-levels-through-breath/
• Bionic Pancreas
http://bionicpancreas.org/
• JDRF
http://jdrf.org.au/research/treating-type1diabetes#sthash.GsbJWU1Y.dpuf
Steam Cell Research
http://diatribe.org/issues/67/new-nownext/2#sthash.5tC8E91X.dpu
Early phase 1/2 clinical trial of VC-01: a novel cell
replacement therapy for type 1 diabetes
This is the end for
tonight, but it is
ENDLESS………….
Australian Diabetes Council trading as Diabetes
NSW
Stem Cell progress
• Research from Harvard Stem Cell Institute
(2014 human study: VC-01)
• Discovery of triggering stem cells to
produce insulin
• Work now focusing on encapsulating cells
to “hide” from immune system