Illinois Chapter - Spring 2007 LIFE Newsletter
Transcription
Illinois Chapter - Spring 2007 LIFE Newsletter
Illinois Chapter 20458_ALF Newsletter.qxd Alfred Baker, MD John Brems, MD S. Martin Cohen, MD Scott Cotler, MD Amanda DeVoss, PA-C Steven Flamm, MD Daniel Ganger, MD Jeffrey Goldman, MD Donald Jensen, MD Alan Koffron, MD Mary Kozlowski, RN Nancy Leone, RN J. Michael Millis, MD Ken O’Riordan, MD Nikunj Shah, MD Kathleen Shortridge, RN David Van Thiel, MD James Williams, MD Monique Williams, RN Rockford Yapp, MD Hon. Jesse White Estella Alonso, MD Chari Aweidah Andrew Enschede Pat Gaddis, RN Dennis Gleason William S. Hackney, III Mary Ellen Hanrahan Michael Kardas Roberta Kramer Thomas J. Layden, MD Patrick Lynch, MD Michael B. Manuel J. Michael Millis, MD Nancy Reau, MD Michael Reschke David A. Sherman Carolyn Smeltzer, RN, EdD Giuliano Testa, MD Frank J. Uvena Charles R.Walgreen, III Elizabeth M.Weil Rockford Yapp, MD Hank Zemola National Helpline 800-GO-LIVER (800-465-4837) 180 N. Michigan Ave. Ste 1870, Chicago, IL 60601 tel: 312-377-9030 | fax: 312-377-9035 www.illinois-liver.org Co-Chairs Giuliano Testa, MD Pat Gaddis, RN Donald M. Jensen, MD, President Daniel E.Weil, Vice President John B. Schwemm, President Emeritus Page 1 Medical Advisory Committee 9:50 AM Board of Directors 3/14/07 Non-Profit Organization US Postage PAID American Liver Foundation Jacqueline A. Dominguez Executive Director Elyse E. Barson Community Events Manager Brandon M. Combs Program Manager Allison R.Warner Administrative & Events Assistant Staff Ana Grzybek Adrienne Houghton Christine Kelly Rebecca Long Rohit Satoskar, MD Karin Schwab Clayton Schaefer William T.Warmouth Ashley Webb Laura Wilson William S. Hackney, III, President Jill Sperling, Vice President Lucia Girolamo, Secretary Michael Gleason, Treasurer Junior Board 2 5 6 7 Junior Board Comes of Age Chicago Wolves Upcoming Events 13 2006 Education Highlights 15 16 Membership Board & MAC Listing Clinical Trials Insert 15 Liver Centers Kids Section/Support Groups 14 10-12 Special Marathon Section Walk/Run The Next Generation 8-9 4 Board of Directors Christopher Kennedy Lawford: Hepatitis C Symposium 3 Nutritional Health and Liver Disease In This Issue For more details on the Run For Research Team see Special Marathon Section on Page 10. Continued on page 2 Sigal, from the New York Weill Cornell Medical Center, and colleagues at the Mount Sinai School of Medicine in New York, tested their theory in 65 patients from a liver transplant program, who had HCVrelated cirrhosis. Dr. Samuel H. Sigal and colleagues theorize that diabetes predisposes a cirrhotic patient to hepatic encephalopathy and its exacerbation by increasing ammonia levels as a result of delayed emptying of contents of the stomach and slowed intestinal motility contributing to bacterial overgrowth. Constipation often precedes the development of hepatic encephalopathy. Hepatic encephalopathy is a complication of cirrhosis of the liver. Toxic substances like ammonia that accumulate in the blood and impair the function of brain cells are believed to be contributing factors. NEW YORK (Reuters Health) - In patients with cirrhosis of the liver due to infection with hepatitis C virus (HCV), the presence of diabetes is associated with earlier onset and greater severity of liver or "hepatic" encephalopathy, according to results of a prospective study. Diabetes May Worsen Liver Encephalopathy National News Clinical Trial Research: Marathon weekend festivities were kicked off at the Health and Fitness Exposition held at McCormick Place on Friday, October 20th & Saturday, October 21st. The Exposition included: packet pick up, runner's services & information, 60 participating charities, including an ALF booth, and over 150 exhibitors featuring the newest designs in running apparel as well as the latest developments in sports, fitness and nutrition. Continued on page 10 For the sixth year, The American Liver Foundation, IL Chapter's Run for Research Team was one of sixty charities affiliated with the LaSalle Bank Chicago Marathon. With over 90 runners hailing from the west coast to the east coast, the Run for Research Team, not only created awareness about liver diseases, liver health and organ donation, but raised a record $150,000 to help fund liver disease research. By: Elyse Barson 2006 Run for Research Team Raises Record Funds for Disease Research Liver Information For Everyone American Liver Foundation Illinois Chapter 3/14/07 9:50 AM Page 3 The Illinois Chapter is extremely excited about our next endeavor to fulfill our mission! On Wednesday, May 2, 2007, we will be traveling to Springfield, IL to advocate for increased awareness and funding of hepatitis programs and support. We are inviting all of our membership to participate on behalf of people with viral hepatitis. For more information, please call Brandon at 312-377-9030 x13 or email brandon@illinois-liver.org. May 2nd is Viral Hepatitis Awareness Day! PAGE 2 Serum carotenoid levels can be obtained as a costly blood test and are not typically ordered because it is seldom covered by insurance. However through a method know as Raman Spectroscopy, carotenoid levels can be measured non-invasively. A device is used to shine light through the skin (typically the palm of the hand). The light interacts with carotenoid molecules in the skin causing them to vibrate and thereby reflecting back light at a greater wavelength. The device is able to read the amount of reflected light and generate a quantitative analysis of the body's skin carotenoid level. Continued on page 3 The liver has a role in our body's "waste management system" that detoxifies harmful substances and is a key contributor to our immune system. The capacity to regenerate along with the ability to function even in a diseased state is remarkable. Still, the cell structure is dependent upon essential levels of antioxidants to off-set the large numbers of free radicals present in our bodies. Although free radicals are the by-product of cell metabolism, our environment exposes us to many more. Pollution and food additives are the biggest contributors. Aside from the ever-growing problem of obesity, the processed foods we consume outweighs our intake of the nutritional foods rich in antioxidants. This affects all body systems and organs, especially the liver. Free radicals are unstable molecules that seek to bind with other "stable" molecules, making them unstable. This process is known as oxidative stress. The resulting damage affects the way cells replicate. When the DNA, or the genetic code of the cell becomes abnormal, it can set the foundation for diseases such as cancer, cardiovascular disease and diabetes. It also impacts the immune system and lowers the body's defense against attacks from bacteria and viruses. Free radicals also contribute to the aging process. Human studies for the past 25 years have shown that 5-9 servings of foods rich in carotenoids can help prevent chronic disease. Carotenoids are naturally occurring organic pigments found in plants. Blueberries, tomatoes, squash and other darkcolored fruits and vegetables have high levels in various forms. When consumed, their antioxidant properties protect cells from the harmful effects of free radicals. It is common knowledge that eating at least 5 servings of fruits and vegetables each day is good for the body. A healthy diet affects our growth down to every cell and helps to maintain a healthy immune system. We accept this as fact, but recent technology has provided a way to measure nutritional status in a non-invasive way. Dr. Stuart Hui, DC, ATC/L Kelly Hofmann, RN, MSED Measuring Nutritional Health and Liver Disease These findings "emphasize the importance of optimizing diabetic control," Sigal's group writes in the American Journal of Gastroenterology. They caution that their study included only cirrhotic patients with HCV and so it "should not be interpreted to imply that the presence of diabetes is invariably associated with hepatic encephalopathy." Sigal and colleagues found that diabetics had significantly more severe hepatic encephalopathy, at earlier stages of liver dysfunction, compared with nondiabetic subjects. However, the investigators discerned no relationship between cirrhosis severity and hepatic encephalopathy. Eleven (17 percent) had no evidence of hepatic encephalopathy, 33 had mild hepatic encephalopathy, and 21 had severe hepatic encephalopathy. Twenty patients had diabetes, including one (5 percent) who had no hepatic encephalopathy, seven (35 percent) who had mild hepatic encephalopathy, and 12 (60 percent) who had severe hepatic encephalopathy. Clinical Trials Research: Diabetes continued from page 1 20458_ALF Newsletter.qxd University of Illinois-Chicago Medical Center 840 S. Wood Street, MC 787 Chicago, IL 60612-7323 312.996.3800 Transplant Surgeons: Michael Abecassis, MD Alan Koffron, MD Rush University Medical Center 1725 W. Harrison, Suite 306 Chicago, IL 60612 312.942.8910 Hepatologists: Joseph Ahn, MD S. Martin Cohen, MD Gastroenterologists: Mark Demeo, MD* Ali Keshavarzian, MD* John Losurdo, MD* Karen Sable, MD** University of Chicago Hospitals 5841 S. Maryland Avenue, MC 4076 Chicago, IL 60637 773.702.2394 Hepatologists: Donald Jensen, MD Smurti Mohanty, MD *also sees patients at the Oak Park office A=Aurora; E=Evanston; LF=Lake Forest **has offices in Highland Park and Skokie Transplant Surgeons: Forrest Dodson, MD Transplant Surgeons: J. Michael Millis, MD Giuliano Testa, MD Gastroenterologists: Alasadi Rameeez, MD Michael P. Jones, MD Terrence A. Barrett, MD Peter J. Kahrilas, MD Alan L. Buchman, MD M. Rosario Ferreira, MD John E. Pandolfino, MD Ikuo Hirano, MD Christian G. Stevoff, MD Colin W. Howden, MD Arvydas Vanagunas, MD FOR PEDIATRIC MATTERS: Children's Memorial Hospital 2300 Children's Plaza, Box 57 Chicago, IL 60614 $250 $100 $50 $25 [ ]$50 Email (optional): ) / / – – [ ]Other $ PAGE 15 Please return this form to ALF-Illinois Chapter, 180 N. Michigan Ave. Ste 1870, Chicago, IL 60601 or fax to 312.377.9035. Phone: ( Institutional Membership Signature: Exp.Date: Card Number: – [ ] MasterCard Name As It Appears on Card: [ ] VISA [ ]$250 [ ] American Express [ ]$100 Please charge my gift to my: [ ]$25 Corporations, Businesses, Notfor-Profits, etc… Hepatologists, Surgeon’s, GI’s, Primary Care Physicians, etc… Physician Membership Nurses, Social Workers, Dieticians, etc… Professional Membership General Public Individual Membership Please accept my contribution of: Please note: This reference list is for informational purposes only. The American Liver Foundation (ALF) does not, under any circumstance, recommend particular medical professionals or treatments for specific individuals. The ALF does not engage in the practice of medicine. The ALF Illinois Chapter makes every attempt to continually update this reference sheet. Please know it is not inclusive of all Illinois' hepatologists and/or gastroenterologists. Rush University Medical Center 1725 W. Harrison, Suite 306 Chicago, IL 60612 312.942.8910 Pediatric Gastroenterologists: Randolph M. McConnie, MD (A, E) John D. Lloyd-Still, MD (LF) Richard H. Sandler, MD (LF) Pediatric Gastroenterologists: Ranjana Gokhale, MD Stefano Guandalini, MD Peneet Gupta, MD Barbara S. Kirschner, MD Pediatric Hepatologists: Ruba Azzam, MD University of Chicago Hospitals 5841 S. Maryland Avenue, MC 4076 Chicago, IL 60637 773.702.6418 Pediatric Gastroenterologists: B. Li, MD Suzanne Nelson, MD Timothy Sentongo, MD Pediatric Hepatologists: Estella Alonso, MD Karan Emerick, MD Humberto Soriano, MD Ricardo Suparino, MD Peter Whitington, MD 773.880.4354 of the Illinois Chapter Local Hepatologists - ALF Medical Advisory Committee Members Dr. Jeffrey Goldman Dr. Patrick Lynch Elmhurst Clinic Dr. Rockford Yapp Advocate Good Samaritan Transplant Surgeons: Enrico Benedetti, MD Jose Oberholzer, MCD Howard Sankary, MD Hepatologists: Scott Cotler, MD Tom Layden, MD Nikunj Shah, MD Gastroenterologists: Russell Cohen, MD Charles Dye, MD Ira Hanan, MD Stephen Hanauer, MD Laura Harrell, MD Sunanda Kane, MD Jeanette Newton-Keith, MD Karen Kim, MD Joseph Kirsner, MD David Rubin, MD Carol Semrad, MD Irving Waxman, MD Charles Winans, MD Nancy Reau, MD Helen Te, MD Gautham Reddy, MD Become A Member Select your membership level from the list below. Northwestern Memorial Hospital 675 North St. Clair Suite 15-250 Chicago, IL 60611 312.695.5620 Hepatologists: Andres Blei, MD Transplant Surgeon: John Brems, MD Gastroenterologists: Rani Chintam, MD Sohrab Mobarhan, MD Khondker Islam, MD Thomas Schnell, MD Michael Klamut, MD Stephen Sontag, MD Jack Leya, MD Edwin Zarling, MD, FACP Hepatologists: Sonu Dhillon, MD Loyola University Medical Center 2160 S. 1st Avenue Maywood, IL 60153 708.216.0364 Gastroenterologists: Juan Engel, MD Marc Fine, MD Hymie Kavin, MD Mani Mahdavian, MD Dean Silas, MD Gastroenterology & Liver Disease Specialists (at Lutheran General) 1875 Dempster, Suite 410 Park Ridge, IL 60068 847.318.9595 Hepatologist: Ken O'Riordan, MD Hepatologist: Daniel Ganger, MD, FACP Steven Flamm, MD Richard Green, MD Laura Kulik, MD Josh Levitsky, MD Mary Rinella, MD Chicago Area Liver Centers Central DuPage Liver Health Center 25 North Winfield Road Winfield, IL 60190 630.933.5483 3/14/07 9:50 AM Page 5 I A P I p D S S D E N E R G Y O S L I R J W v G S S L E D S P F I K O P E I J J D P V F D F G V D T O D T O L B O F M F V B N E H J R D O L F E E N S V R W G H N M I N M G R I O P L E B I W E Y J I N E R H I O Y K D C F F E S D K C L O A P P H V R G A N F C I E L L L J O R G V H M O U A F H J N U H B V G L E W D N E X C S F N E T B H E A L T H Y S F S D I C B O D Y D K F K S C O S E D D 7. stores energy by like a battery. 6. stores Iron and other vitamins and minerals. 5. makes bile to help digest food. 4. manufactures proteins for your body to stay healthy and grow. 3. is essential to your overall wellness!! 2. is the only organ that can regenerate. 1. is the largest organ in the human body. The Liver: Winfield Day: First Thursday of Each Month Time: 7:00p.m. to 8:30p.m. Contact: Kelly Hofmann, 630.399.5709 Location: Central DuPage Hospital 25 N.Winfield Rd Quad Cities Day:Third Tuesday of Each Month Time: 6:30p.m. to 8:00p.m. Contact: Brandon Combs, 312.377.9030 ext.13 Location: First Evangelical Lutheran Church 15th Ave. & 13th St. Moline, IL PAGE 14 Urbana Day: Second Wednesday of Each Month Time: 6:00p.m. to 7:30p.m. Contact: Penny Shonkwiler, 217.239.7827 Location: Carl Forum 602 W. University, Urbana, IL Springfield Day:Third Monday of Each Month Time: 7:00p.m. to 9:00p.m. Contact: Don Hunt, 217.789.2182, Ext. 111 Location: Springfield Department of Public Health 1415 East Jefferson, Main Floor Conf. Room Maywood Day: First Monday of Each Month Time: 6:00p.m. - 7:30p.m. Contacts: Susan Long (708.216.5454) Location: Loyola Medical Center, Outpatient Center Third Floor, Urology Waiting Room 2160 S. 1st Avenue, Maywood 60153 Decatur Day: Fourth Tuesday of Each Month Time: 6:30p.m. to 8:00p.m. Contact: Debra Durbin, 217.423.6988, Ext. 1328 Location: Macon County Health Department 1221 E. Condit Rockford Day:Third Thursday of Each Month Time: 6:45p.m. to 9:00p.m. Contact: Brenda Erwin, 815.391.5100 Odd Months: Harlem United Methodist Church 8401 North Alpine Road Even Months: Brooke Road United Methodist Church 1404 Brooke Road If you are interested in starting a support group in your area, please contact the Illinois Chapter of the American Liver Foundation at 312.377.9030. Online Support Group If interested in the online support group with ONLINE MESSAGE BOARD, send an email to brandon@illinois-liver.org. PBCers Contact: Ivette Williams, 773.779.7602 or e-mail idw87@aol.com Fairfield, IA Day: Monday Evenings Time: 7:00 PM Contact: Robert, 641.233.0105 Location: New Life Community Church 500 W.Washington St. Fairfield, IA Northwest Indiana Day: Fourth Thursday of Each Month Time: 6:30p.m. to 8:00p.m. Contact: Linda Zych, 219.836.3477 Location: Community Outpatient Center 9660 Wicker Boulevard, St. John, IN Support Groups T R E N I U V A L T I U T I G Arlington Heights Day: First Monday of Each Month Time: 7:00p.m. to 9:00p.m. Contact: Brandon Combs, 312.377.9030 ext. 13 Location: Northwest Community Healthcare Room 1-6 (Across from Auditorium) 800 W Central Rd L M W C B N O L U I P K H F S the underlined words ALF Kids Word Search: Find 20458_ALF Newsletter.qxd Note: We presented this material for several ALF support groups and at the Town Hall meeting held at Rush University on September 25, 2006. The opportunity to check nutritional status with a biophotonic scanner was available. People responded with a strong interest and motivation. Several made immediate changes in diet and some began taking supplements to increase antioxidant levels. Considering the non-invasive measurement and recommendations for nutritional changes and supplements, the potential for further research is evident. Patients who are compromised by advanced liver disease and/or the side effects of viral treatments can benefit from building and preserving cell structure and integrity. Lawford went on the interferon protocol, which is quite similar to chemotherapy, for eleven months. He injected himself once a week, taking another antiviral, ribavirin twice a day orally. The medication caused him to lose twenty pounds, feel like he had a bad flu 24/7 and depression to the point of contemplating suicide. Unfortunately the tests concluded that he had hepatitis C and a presclerotic liver with bridging fibrosis. Lawford needed to undergo treatment if he had any hope of eradicating this potentially deadly virus. He went through a period of doubt and resistance to treatment, and because of rumors that his condition was untreatable, he felt quite hopeless. Lawford explained that over the years, physicians continued to give him a renewed sense of his good overall health. Any prior tests for hepatitis had come back negative. After going for a physical in Beverly Hills, one physician insisted that he be tested for hepatitis c and undergo a liver biopsy. in his teen years. In time, Lawford contracted hepatitis A, B and C. Although Lawford has maintained sobriety for the past 20 years, it was not until 2001 that he learned of his hepatitis C. Source: Carsten and Burke "Nutritional Significance and Measurement of Carotenoids" Current Topics in Neutraceutical Research Vol. 2 No. 2 pp79-91,2004 Measuring carotenoid levels can be a strong motivator for increasing fruits and vegetables in daily diets. For patients with liver disease, sparing liver damage and supporting the immune system can provide a better quality of life and perhaps delay potential effects of end stage disease and transplantation. Scores range from 10,000 and below to 50,000 and above. A typical American is in the range of 18,000. A person with a high antioxidant level is in the 50,000 range. PAGE 3 Nutrition Continued: In spite of his seemingly idyllic childhood, his early life was marked by the tragic assassinations of his two dear uncles, Jack and Bobby. He soon succumbed to the drug scene of the 1970's Born into privilege, son of famed Rat Pack actor, Peter Lawford and Patricia Kennedy, sister of John F. Kennedy, Christopher Kennedy Lawford grew up with presidents and movie stars as close relatives and personal friends. He recalled Marilyn Monroe teaching him how to do the twist in his living room at the age of 6. He also shared fond memories of his uncle's announcement of candidacy for president. Dr. Rockford Yapp, member of the American Liver Foundation Illinois Chapter's Medical Advisory Committee, and Christopher Kennedy Lawford, actor and author, came together at a free public symposium sponsored by Roche Pharmaceuticals and coordinated by the ALF, IL Chapter on December 13th at the Hyatt Regency, Chicago to discuss Hepatitis C. By Elyse Barson Kelly Hofmann is a RN and coordinator for the Winfield ALF support group and an educator for the American Liver Foundation Illinois Chapter. 630.399.5709 kellyhof@ameritech.net Dr. Stuart Hui is a Chiropractic Physician and Certified Athletic Trainer specializing in Sports Medicine and Nutrition. He practices in Naperville and Elgin and has a special interest in helping patients with liver disease and side effect management. 847.833.9354 Dr.shui@gmail.com The ALF strongly recommends consulting your physician regarding any dietary modifications. Despite some rocky roads, Lawford feels privileged to use one of his family's greatest strengths, their commitment to public service and to make a difference. in the lives of those that struggle with addiction and suffer from hepatitis C. Lawford discussed his surprise at the lack of public awareness and understanding about hepatitis A, B and C. He shared that he initially wrote his book, Symptoms of Withdrawal: a Memoir of Snapshots and Redemption, to begin a career as an author. However, he quickly realized what a powerful mouth piece and an advocate he could be for those affected by hepatitis C and addiction. Audience members were touched by his experiences and welcomed the opportunity for a question and answer session. Despite his extreme discomfort, he recalled the treatment being a life changing experience. His daily yoga routine really helped him through this particularly tough time in his life. While he was fortunate to be cleared of the virus in only four weeks, he still had to endure a difficult process to sustain an effective response. Public Program Proves that Famous are Not Immune to Hepatitis C 3/14/07 9:50 AM Page 7 PAGE 4 In an effort to provide education and resources to a diverse population in Chicago, the Illinois Chapter partnered with the Chicago Defender newspaper. The Defender is a trusted source of information for the African American community. They have challenged African Americans to collectively loose one million pounds over the course of one year. The Illinois Chapter identified this as a chance to provide liver wellness information and education at an event where participants are concerned about their health and wellness. Every month since July, the ALF has hosted a vendor booth at this event providing information, resources and referrals for screenings to participants. Check us out in May 2007 for the final installment of our partnership with the Chicago Defender and their Million Pound Challenge. See if the community was able to meet the challenge with the help of the ALF. Are you interested in learning more about local research?. Check out the Educational Programs on our website, www.illinois-liver.org, to review research articles (layman explanations for the general public) authored by the experts on our Medical Advisory Committee. Our chapter website, www.illinois-liver.org, offers breaking news from around the globe. We add new content weekly. We encourage you to use our accredited website as a resource for all of your liver information. We are continually searching for professionally networked Directors and are open to nominations. As is natural for notfor-profit organizations, our director positions are strictly volunteer. Directors do not receive any form of financial compensation. As a matter of fact, they are our most generous donors in terms of personal dollars and contacts. They are truly helping us make a difference. We're excited to announce that Dan Weil will assist Dr. Jensen in the position of vice president. Mr. Weil, and his wife Liz, joined our Chapter Board approximately seven years ago. An example of Mr. Weil's impact on our success includes chairmanship of our Golf Classic, quadrupling the event net revenues and securing our first ever event sponsorship. Mr. Weil is also the chair of our nominating committee and spends many hours interviewing potential board candidates. Rest assured, we won't be left without an outstanding successor. For the past two years, Dr. Donald Jensen has served as vice president of the Board. He assumed the position of president on January 1, 2007. Dr. Jensen has been one of our most ardent supporters for many, many years; encouraging his colleagues and patients to use our resources. We look forward to further growth especially as he simultaneously serves on the American Liver Foundation National Board of Directors. The Illinois Chapter Partners with the Chicago Defender for the 2006 Million Pound Challenge Unbelievably, another two year cycle is coming to a close. It is with sadness that we recognize the culmination of the two year presidency term of Dennis Gleason. Mr. Gleason has provided exemplary leadership during his tenure. He has been instrumental in bringing our events to new heights and is responsible for the recruitment of many of our outstanding Directors. He has gone as far as demonstrating his commitment to the Chapter by involving his entire family in our initiatives-you will find Karen, his wife, a familiar face at all of our events; he's garnered support from his daughter, Susan, from as far away as Boston; and his son, Michael, is a very active member of our Junior Board of Directors. We are thrilled by the fact that Mr. Gleason will continue to remain active on our Board. The Illinois Chapter is tremendously grateful for the enthusiasm, expertise, and dedication of the Directors of our Board. Each and every member shares a strong sense of responsibility for our mission of research, education and advocacy for liver wellness and for those who are affected by liver diseases. They are largely responsible for the success of our fundraising, working diligently to populate our events and bring new life to our organization. Illinois Chapter Thanks Dennis Gleason for Two Great Years 20458_ALF Newsletter.qxd In addition, guests had the option of choosing to attend breakout sessions that allowed for discussion of a specific topic in a small group led by medical professionals. Topics included: Nutrition & Liver Disease presented by Judith Fitzhugh, Transplantation & Living Donors, presented by Giuliano Testa, MD, University of Chicago Hospitals, Alternative Treatments & Chinese Medicine, presented by Kelly Hofmann, RN and Stuart Hui, DO, Caregivers: Caring for your Loved Ones, presented by Susan Long, LCSW, Loyola University Medical Center, Depression & Chronic Illness, presented by Aida Mihajlovic, MD, NASH/Fatty Liver, presented by Smruti Mohanty, MD, Murphy, RN who shared the Power of Humor & Healing. We hope to see you at our next Town Hall Meeting. Check our website for updates: www.illinoisliver.org or call 312.377.9030. Attendees expressed positive feedback through a program evaluation. Guests were quite impressed by the variety of topics presented and their opportunity to discuss questions and concerns with premier liver specialists at no charge. Attendees were also excited to learn more about the American Liver Foundation, IL Chapter's mission and the benefits to becoming a member of our organization. Others were eager to continue their dialogue about liver-related diseases and inquired about joining one of the Illinois Chapter’s twelve support groups. University of Chicago, Viral Hepatitis presented by Josh Levitsky, MD, Northwestern University. While eating, 150 attendees listened to participants from University of Chicago Hospitals, University of Illinois Medical Center, Cook County, Loyola University Health System, Rush University Medical Center and Northwestern Memorial Hospital battle over the latest liver-related disease topics. The evening, sponsored by Premiere Advocates, which included: Roche Pharmaceuticals and Schering Plough; Partner Advocates: Damer & Cartwright Specialty Pharmacy and Walgreens Specialty Pharmacy; and Participating Advocates: Axcan Scandipharm and Gilead began with a brief networking session between medical professionals, industry partners and volunteers; followed by a savory four course meal. The 2006 Academic Debates, in memory of Rush University Medical Center Fellow Kevin Schaefer, was held on Thursday, November 30th at the Hotel InterContinental, Chicago. PAGE 13 Topic #3: Transplantation Should We Use Marginal Donors for Otherwise Good Risk Patients with HCC, Beyond Milan Criteria? Topic #2: NASH/Fatty Liver Using Medication to Treat Fatty Liver Disease: Are we there yet? Under the direction of mentor, Dr. Bashar Attar, fellows Dr. Steven Keilin and Dr. Cory Halliburton from Cook County discussed advantages of treatment while under the direction of mentor Dr. Sonu Dhillon, fellows from Loyola University, Dr. Ashish Arora and Dr. William Levit illustrated disadvantages of treating. Such Topics Include: Topic #1: Hepatitis C Mild Disease on Biopsy for Genotype 1 Treat or do not Treat? Under the direction of mentor, Dr. Nancy Reau, fellows Dr. Nidhi Singh and Dr. Rohit Satoskar from University of Chicago discussed advantages of treatment while fellows under the direction of mentor Dr. Jamie Berkes from University of Illinois, Dr. Eric Kallwitz and Dr. Samuel Tesfay illustrated disadvantages to treating. Members of the audience posed compelling questions to presenters. Fellows were forced to think critically about their topics and formulate educated concise answers. They all did a phenomenal job synthesizing complicated data to form their arguments. Congratulations to all. Debate winners were: Topic #1 Treat, University of Chicago, Topic #2 - No, Loyola University and Topic #3 - No, Northwestern Memorial Hospital. All participants received a cash prize for their efforts. Under the direction of mentor, Dr. Forrest Dodson, Resident Dr. David Lee from Rush University discussed advantages of treatment while under the direction of mentor Dr. Michael Abecassis, fellow from Northwestern, Dr. Paul Alvord illustrated disadvantages of treating. Chicago Area Fellows Battle Over Liver Disease Topics By: Elyse Barson The program featured keynote speakers Nikunj Shah, MD, University of Illinois at Chicago, who presented Liver Disease Research Updates, John Brems, MD, Loyola University Medical Center who discussed the Development & Progression of Liver Cancer and Joan This free program was open to liver disease patients, caregivers and the general public. Guests enjoyed a complimentary continental breakfast while networking with partners and medical professional industry. Cancer caused by hepatitis C? Is it possible that smiling and laughing help alleviate symptoms of a chronic disease? What better place to ask questions than at the "Exploring Liver Diseases Town Hall Meeting," held at Rush University Medical Center on Saturday, September 30th. What causes fatty liver disease? Is Liver By: Elyse Barson Public Education: Town Hall Meeting Explores an Array of Interesting Topics 3/14/07 9:50 AM Page 9 John McWhorter Keith Klebacha Aureo Celaya Jose Oberholzer, MD Justin Catches 2:58:49 3:08:15 3:14:13 3:18:30 3:18:34 PAGE 12 Karin Martens Kesha Quigg Missy Matsas Michelle Platts Carrie Dugan 3:39:33 3:54:40 3:54:48 4:02:09 4:05:44 The Illinois Chapter staff looks forward to meeting additional members of the Dutch community in Chicago, and working closely with them to help create awareness about liver related diseases both locally and internationally. No matter what country you choose to inhabit, liver diseases do not discriminate. While the ALF, IL Chapter has made great strides in creating awareness and raising funds for disease research, there is still much to be done. During a brief speech, Andrew capitalized the importance of the Dutch giving back to their adopted communities. Although the Dutchrunners come from The Netherlands, (and many expect to return there) it is important for them to give back to their adopted home community, and take an interest in those issues that affect all of us. Executive Director of the ALF, IL Chapter, Jackie Dominguez, graciously accepted a symbolic check from all of the Dutchrunners that amounted to more than $8,000 to help fund liver disease research. On the eve of the Marathon, IL Chapter staff was invited by the Netherlands Club of Chicago and the NetherlandAmerican Foundation Dutch Chicago Business Exchange to attend a pasta dinner at the Standard Club. A few years after his diagnosis and recuperation from the disease, Andrew met Jackie Dominguez, Executive Director of the ALF, IL Chapter. He learned of the opportunity to participate in the Chicago Marathon and raise funds for disease research as part of the ALF's Run for Research Team. Andrew decided that running with his healthy liver would be a great return to the world of endurance sports in which he participated prior to his illness, but more importantly a way to create awareness about liver related diseases. own in almost all cases. Patients are advised to reduce the pace of their daily activities to match their loss of energy as well as maintain a balanced diet with plenty of fluids. Top 5 Fastest Men & Women Hepatitis A is likely to occur wherever hygiene may be a problem. Symptoms of Hepatitis A can occur 2-7 weeks after infection with the virus. Low energy is the most common symptom. Medicines are not used to treat infection because the symptoms are usually mild and the disease goes away on its Andrew's charity of choice was quite appropriate. As a result of travels to Cyprus, he had developed hepatitis A. A member of the Club and Exchange, Andrew Enschede, recently ran the LaSalle Bank Chicago Marathon as part of the ALF's Run for Research Team. In addition, several other club members formed a group called the Dutchrunners who ran and raised funds for worthy causes. Dutchrunners, Andrew Enschede and Karin Martens, raised more than $7,000 to help fund liver disease research. In addition, Karin qualified for the Boston Marathon. With more than 500 members, the Club and the Exchange have developed a strong presence in both business and social spheres. They organize events that appeal to a variety of audiences. Such events include: community volunteer activities, cultural events, intramurals, the Dutch American Heritage Day party, business lunches, symposia and even a running team - the Dutchrunners. There are numerous Dutch people living in and around the Chicago area- and they are very active. Many of them are members of the Netherlands Club of Chicago (www.dutchclubchicago.com) and the NetherlandAmerica Foundation Dutch Chicago Business Exchange (www.dcbex.com). You don't have to travel abroad to enjoy a taste of Dutch culture. Just look out your window, it's available in your own backyard! By: Elyse Barson The Dutch Connection - A Substantial Gift to the Illinois Chapter from Dutch Chicagoans 20458_ALF Newsletter.qxd * Participate in regularly scheduled meetings * Volunteer at the organization's community fundraising events, health and fitness esposItions, educational programs and other activities. * Coordinate a Junior Board-organized fundraising event. * Contribute innovative ideas to help promote fundraising and awareness of liver diseases, liver health and organ donation. The Junior Board is an integrated part of the ALF Illinois Chapter and are dedicated to helping fulfill our Mission. Guests munched on appetizers and enjoyed lively music provided by a DJ. Not only did we raise awareness at this event, we also raised $1,630 to help fund disease research. Join us next year for the 2nd annual event-it promises to be a great time! Stay tuned for details. More than 80 young business professionals gathered with the Illinois Chapter Junior Board for the Inaugural Summer Soiree held at Lucille's in Lincoln park last August. Everyone came together to learn more about the American Liver Foundation and ways they could get involved and make a difference in their community. Sizzling Fun with the Junior Board at their Inaugural Summer Soiree This year, the ALF Run For Research Team had over 100 members who have so far raised in excess of $138,000. As is true with almost every event that the ALF now sponsors, the members of the Junior Board were there, literally every step of the 26.2 mile way. I cannot begin to fully express my deep and sincere appreciation to each and every member of the Junior Board for all that you have done to make our Junior Board a resounding success this year and for laying the groundwork to continue that success for years to come. Now, as the year comes to a close, we on the Junior Board can look back and reflect on just how far we've come. In fact, I am pleased and proud to report that the Junior Board not only met, but exceeded, almost every one of its recruitment, participation and fundraising goals this year. We've recruited three new Junior Board members, begun the annual tradition of a Junior Board Summer Soiree and through all of our efforts we've contributed over $16,000 in much needed fundraising dollars to the ALF. And we're not done yet. The Junior Board is already discussing increasing its size, creating, organizing and managing even more Junior Board events and making an even bigger impact on the ALF next year. It's truly a thrilling time to be a part of the Junior Board and witness its true potential. PAGE 5 I've been volunteering in various capacities with the ALF ever since. Last year I was elected to the ALF's Board of Directors and asked if I would consider guiding its relatively new Junior Board of Directors. I met the existing members of the Junior Board and witnessed first-hand their dedication to and passion for the ALF and again my decision was made. With the help of About four years ago as I prepared to run my first marathon, I was approached about running for a charity. I had never really considered running the marathon for charity but the more I thought about it the more sense it made. I was training and running anyway, why not help someone else along the way. My search started with some well-known names - all of which had hundreds of runners, unknown staff and considerable corporate backing. And then I came across a smaller charity with just a few runners, a local staff and that little something extra - that charity was the Run For Research Team of the American Liver Foundation Illinois Chapter. I'd never been affected by liver disease, didn't personally know anyone who had been affected by liver disease and didn't know much about liver disease. In other words, I had no connection whatsoever to the American Liver Foundation. However, once I met the dedicated and passionate staff, led of course by the indomitable Jackie Dominguez, my decision was made. That first year, I was one of 39 runners that raised a little over $40,000 for liver disease research. the indefatigable Carolyn Watkins, our main support line at the ALF, the Junior Board immediately embarked upon a mission to create its own character and chart its own path. We set lofty but achievable recruitment, participation and fundraising goals. We developed Junior Board events in addition to the main events offered by the ALF. We set out to increase awareness of liver disease, the ALF and the Junior Board among a younger demographic. Junior Board Comes Of Age By William Hackney ,Jr. Board President and member of the Board of Directors 3/14/07 Page 11 this season. It is no coincidence that their opening day festivities included an opportunity for Wolves' fans to donate to the American Liver Foundation, Illinois Chapter. The Chicago Wolves organization has been a loyal partner of the Illinois Chapter for many years, and dedicated their opening night to liver wellness. The Chicago Wolves Hockey Team took the ice on Saturday, October 14th for the first time Chicago Wolves Hockey Team is Loyal to Illinois Chapter 9:50 AM 07:00 PM 07:00 PM 07:30 PM 07:00 PM 07:30 PM 07:00 PM 07:00 PM 07:30 PM 07:00 PM 04:00 PM 07:00 PM 07:00 PM 07:00 PM 07:30 PM 07:30 PM 01/03/2007 01/05/2007 01/06/2007 01/09/2007 01/12/2007 01/13/2007 01/17/2007 01/19/2007 01/20/2007 01/21/2007 01/23/2007 01/26/2007 01/27/2007 02/02/2007 02/03/2007 Score Score Houston Aeros @Omaha Ak-Sar-Ben Knights @Milwaukee Admirals Peoria Rivermen Wilkes-Barre/Scranton Penguins Hamilton Bulldogs Toronto Marlies @Peoria Rivermen San Antonio Rampage Toronto Marlies @Iowa Stars @Omaha Ak-Sar-Ben Knights @Iowa Stars @Manitoba Moose @Manitoba Moose Opponent 02/05/2007 02/07/2007 02/09/2007 02/10/2007 02/11/2007 02/17/2007 02/18/2007 02/23/2007 02/24/2007 02/25/2007 03/03/2007 03/04/2007 03/07/2007 03/10/2007 03/11/2007 D ate 06:30 PM 06:30 PM 06:30 PM 03:00 PM 04:00 PM 07:30 PM 05:00 PM 07:00 PM 07:00 PM 03:00 PM 07:00 PM 05:00 PM 07:00 PM 07:00 PM 03:00 PM Time @Toronto Marlies @Hamilton Bulldogs @Hamilton Bulldogs @Toronto Marlies Syracuse Crunch @Houston Aeros @Houston Aeros @San Antonio Rampage Omaha Ak-Sar-Ben Knights Omaha Ak-Sar-Ben Knights Hamilton Bulldogs San Antonio Rampage Houston Aeros Milwaukee Admirals Peoria Rivermen Opponent 03/14/2007 03/16/2007 03/17/2007 03/23/2007 03/24/2007 03/25/2007 03/28/2007 03/30/2007 03/31/2007 04/06/2007 04/07/2007 04/13/2007 04/14/2007 04/15/2007 D ate 07:00 PM 07:00 PM 07:00 PM 07:00 PM 07:00 PM 03:00 PM 07:00 PM 07:30 PM 06:00 PM 07:00 PM 07:00 PM 07:00 PM 07:00 PM 05:00 PM Time Peoria Rivermen @Omaha Ak-Sar-Ben Knights Milwaukee Admirals @Iowa Stars @Peoria Rivermen Peoria Rivermen Manitoba Moose Milwaukee Admirals @Grand Rapids Griffins @Milwaukee Admirals Grand Rapids Griffins @Milwaukee Admirals Iowa Stars Omaha Ak-Sar-Ben Knights Opponent 57th Street and Lake Shore Drive Exhibit: January 17 – April 29, 2007 Regular priced tickets: $23; $19 seniors, $12.75 for children www.msichicago.org. PAGE 6 Using the ground-breaking preservation process called plastination, BODY WORLDS 2— the second of three anatomical exhibitions by licensed physician and anatomist Dr. Gunther von Hagens—showcases more than 200 real human specimens and more than 20 new full-body plastinates that focus on the locomotive, nervous, respiratory, digestive, cardiovascular and reproductive systems. The exhibit will run through April 29, 2007. To ensure an enriching experience for all, children under the age of 13 must be accompanied by a responsible adult, parent, guardian or school chaperone while in Body Worlds 2. As a friend of our organization, you and up to four guests can take advantage of a special discount on tickets to BODY WORLDS 2. Simply go to www.illinois-liver.org and the coupon is located on the front page of our website. The American Liver Foundation, IL Chapter has partnered with the Museum of Science and Industry to spread the word about the Museum's exhibit, Gunther von Hagens' Body Worlds 2: The Anatomical Exhibition of Real Human Bodies. This awe-inspiring exhibit offers Museum guests another amazing opportunity to investigate the mysteries of human anatomy and physiology. BODY WORLDS 2 is the sequel to BODY WORLDS which had its Midwest debut at the Museum of Science and Industry in 2005. Don’t Miss a Second Chance to See Body Worlds! Time D ate have won five division titles, one regular season title, and three league championships. Special thanks to Courtney Mahoney, Director of Community Relations and Game Operations. She is a pleasure to work with and realizes the importance of creating awareness about liver disease, liver health and organ donation within the community. She is truly helping us to make a difference. The Chicago Wolves play at the Allstate Arena in Rosemont, IL for the American Hockey League. Founded in 1994, the Wolves If you are a hockey fan or simply looking for a family friendly outing, we encourage you to attend a game and cheer the Wolves to victory. Lets join together to thank the Chicago Wolves for their continued support. The Chicago Wolves are a community oriented organization. They have generated large sums of money to support the Illinois Chapter's mission and continue to support our organization by participation in our community events. They sponsor a foursome at our Golf Classic, year after year Skates has entertained children and families at our Walk/Run and they have given fans an opportunity to support us and learn about organ donation at specific games throughout the season. 20458_ALF Newsletter.qxd Summer Edition 06 | PAGE 11 The truth is that we were unaware of the American Liver Foundation, IL Chapter. It was at the 2006 LaSalle Bank Shamrock Shuffle Health and Fitness Exposition. when we received a squishy liver in our race goodie bags that we learned of the ALF, IL Chapter, its mission and our opportunity to run the Marathon and raise money to help fund liver disease research. It seemed like fate had drawn us together. In honor and in memory of our Dad, Richard Gustafson, we had decided to challenge ourselves and join the Run for Research Team. Our Dad passed away in March of 2006 from Primary Liver Cancer caused by hepatitis c. Laurie, Melissa and Rick Gustafson Chicago, IL As a result of my illness, I became involved with the ALF, Illinois Chapter. I ran my first Marathon ever on Sunday, October 22nd as part of the Run for Research Team. By raising funds for liver disease research, I have created awareness about my disease and the ALF. PSC is considered a rare disease and the cause is unknown. It is believed to be related to genetic and immunologic factors. It is not associated with an unhealthy life style, such as alcohol or drug abuse. PSC may occur alone, but in approximately 70% of patients it is associated with intestinal diseases particularly ulcerative colitis. How PSC progresses with each patient is unpredictable. I have Primary Sclerosing Cholangitis (PSC). It is a progressively slow liver disease for which there is no cure or a specific treatment. In time, I may need a liver transplantation. Reese Peck Naperville, IL Few who knew my Mom will ever forget her positive energy, endless optimism, love for others, and her absolute selflessness. On October 22nd, I ran the Chicago Marathon with the ALF's Run for Research Team in her honor and memory. While this was the second marathon that I ran in her honor, it will be the first in which my goal was to raise money for the charity that played a significant role in her treatment. In September of 2003, my Mom, "Gigi", passed away as a result of complications from liver disease at the young age of 67. After contracting hepatitis c from a blood transfusion in 1984, she managed the disease for 19 years before it ultimately destroyed her liver function and took her life. David Gwyn Potomac, MD A Few Faces of the 2006 Run for Research Team Run for Research Team Members were invited to join The LaSalle Bank Chicago Marathon's Executive Race Director, Carey Pinkowski, and Group & Charitable Programs Manager, Kristina Olkowski, at Sidebar Grille, located on North LaSalle Street, on Tuesday, September 19th. Team Members mingled and enjoyed complimentary appetizers and beverages. Team Social Event Run for Research Team Members were invited to join ALF, IL Chapter employee and Oak Park running club member, Allison Warner for a 13 mile fun run on Saturday, September 9th that began at North Avenue Beach. Team Fun Run 5th Year Run for Research Team Member and top fundraiser, David Brown, led an audio conference to discuss effective fundraising strategies on Tuesday, August 21st. Together with Suzanne Muchin, David has generated over $50,000 to help fund liver-related disease research. Team Fundraising Workshop Volunteers: Thank you to Elsa Chua, Doug Doolittle, Robert Herskovitz, Reese & Robin Peck and Allison Warner who educated guests about liver disease, liver health and organ donation. The IL Chapter participated in the 2006 LaSalle Bank Chicago Distance Classic Health and Fitness Exposition at the Hilton on Friday, August 11th and Saturday August 12th. Our participation in the Expo allowed us to create awareness about liver health, organ donation and successfully recruit runners for our Team. Many Run for Research Team Members used the race on Sunday, August 12th as a training run for the Marathon. LaSalle Bank Chicago Distance Classic Half Marathon Team Tid Bits... 3/14/07 9:50 AM Page 13 Richard Bergman Megan Conner Doug Doolittle George Gatto Kelli Hutchens Steve Irwin Kevin Prim Cheryl Westrick $1,500 Robert Harland, MD David Heekin Jill and Steve Sperling Jeremy Sullivan Tip Walker Suzanne Vince $2,000 Stacy Conway Katherine Dudaryk $2,500 Gina Bailey Carrie Dugan Don Sawyer $900 $1,000 Michael Burns/Team Cermak Justin Catches Corey Friedman Cindy Gates Henry Gentile M.J. Guerin Kelly Hofmann Barbara Janszen Keith Klebacha Kevin Maloney Meredith Marks Karin Martens John McWhorter Patti Moffett Jose Oberholzer, MD Alison Oliphant Michell Platts Kelly Pollock Kesha Quigg Brad Rourke Jamie Schmidt Keith Wolfe $3,000 Elsa Chua Mike Gleason Laurie Kogen David Walker All of our Team Members contributed to exceeding our fundraising goal for this event. However, many went above and beyond the minimum pledge goal… Thank you to our dedicated volunteers for making the 2006 marathon weekend a great success: Dr. Jennifer Beverlin, Justin Catches, Elsa Chua, Michael Gleason, Carol & Jim Grimm, Dr. Jennifer Guddall, Emily Harlow, Bob Herskovitz, Carol James, Michael Kardas, Rebecca Long, Robin & Reese Peck, Shelley Rodriguez, Clay & Nicole Schaefer and Jennifer Tedjeske. Marathon route to provide continued support to runners during those last few miles. Both ALF staff and volunteers spotted Run for Research Team Members in their blue singlets and rallied them to the finish line with inflatable hands, signage, cow bells and pom poms. Thank You to the Run for Research Official Team Sponsors: Nick Brewer Robert Herskovitz $3,500 Reese Peck $4,000 David Brown & Suzanne Dave Gwyn $5,500 Andrew Enschede Bobby Weil $6,000 Team Miles for Smiles: Alan Gottleib, Howard Nevins, Tim McPhillips $9,000 Carol & Jim Grimm $12,000 TOP Fundraisers At mile 22, crowds of spectators lined the curb side of what once used to be considered a remote area at the southern end of the On a brisk Sunday, October 22nd, runners and their loved ones were invited into a much needed heated tent, provided by the ALF, located in the McDonald's Charity Village in Grant Park. The tent included a secure gear check and refreshments donated by Clif, Gatorade, Hinckley Springs and Whole Foods. In addition, complimentary massages were provided for Team Members by Dr. Jennifer Guddall and Dr. Jennifer Beverlin, from the Millennium Wellness Group. Photographer Michael Kardas, of Kardas Photography, captured the spirit of running the Marathon on behalf of a charitable cause. 2006 Run for Research Team Raises Record Funds for Disease Research Run for Research 20458_ALF Newsletter.qxd Our Upcoming Events PAGE 7 Celebrating Life Spring Benefit and Abstract Competition 2007 Join us for a peek into the future of ALF! Honor our community leaders and medical professionals at the forefront of the fight against liver disease. Come for an evening of cocktails, hors d’ouerves, reception, and see the exciting presentation of the abstract competition. For tickets and more information, contact Carolyn at 312-377-9030 x14 04/24/07 Nursing Management Series: Hepatitis B Exploring Treatment Options Further Explore Hepatitis B Treatment Options at this 1 AMA PRA credit hour program. Join us for dinner and the presentation. This program is intended for medical professionals. For more information, please call Brandon at 312-377-9030 x13. 04/21/07 Viral Hepatitis Town Hall Meeting Our Annual Hepatitis Town Hall Meeting is back once again and this time more inclusive, with discussions on hepatitis A, B, and C. Come listen to Chicago’s premiere hepatologists and transplant surgeons discuss viral hepatitis, treatments, nutrition, and much more. This program is intended for the general public.For more information, please call Brandon at 312-377-9030 x13. 03/31/07 Liver Disease: Beyond the Basics for the Primary Care Physician The Illinois Chapter is proud to offer our 2nd Annual liver disease educational program for the Primary Care Physicians. This 4 AMA PRA credit hour program will feature University medical professionals offering informative presentations about today’s most pressing disease states. This program is intended for medical professionals. For more information, please contact at 312-377-9030 ext 13. 02/24/07 April: NASH Update June: Hepatitis C Treatment Update Topics are: Join us on the first wednesday of each month at noon for a new Audio Conference. This program is intended for medical professionals.Contact Brandon, 312.377.9030 x13 for more information. Learn Audio Conference ongoing Golf ClassiC Join The American Liver Foundation, IL Chapter for a round of golf at The 10th Annual Golf Classic on Monday, July 16, 2007 at The Highland Park Country Club. Golfers will enjoy lunch, 18 holes of golf, (scramble/team format), golf contests, raffles, free gifts, and an evening reception including awards, cocktails & dinner. Proceeds fund research, education and advocacy for liver wellness and for those who are affected by liver-related diseases. For more information contact: golf@illinois-liver.org or 312377-9030 x15 07/16/07 Viral Hepatitis Awareness Day The Illinois Chapter of the American Liver Foundation and the Chicago Hepatitis Task Force are proud to present the Viral Hepatitis Awareness Day at the Illinois State Capitol Rotunda, 2nd & Capitol, Springfield, IL. Join us at 8:30am for Breakfast and Networking, followed by a 9am presentation, and at 9:30am meet with the legislators. If you are interested in attending, we may be able to assist with you travel, talking points & contacting your legislators. For more information, contact brandon@illinois-liver.org or call 312-377-9030 x13. 05/02/07 3/14/07 9:50 AM Page 15 Brianne Bassett Don Myles Non Stop Dance Productions Skates the Wolf Our top finishers cruised back in to enjoy the party and awards. Congratulations to our top walkers, Belkys Moreno (29:45) and Felipe Gardner (38:58) and The scenery was calm and the walk went quickly. Upon everyone's return, they were welcomed with goodie bags filled with treats, and lunch provided by Moo and Oink. Entertainment was provided by our new DJ "The Don" and a return performance from the hip hop dance group Non-Stop Hip Hop Productions. They added just enough"funk" to the event to keep people moving afterwards. Our pet station was hosted by Dr. Kim Meyers of the Berwyn VCA where participants stopped by and picked up their pet goodie bags. Our kids station was hosted by our own ALF volunteer/magician Oliver Corpuz and a new attraction for the kids was our 4 in1 Crayola moon jump! After the Walk, kids could jump the day away and play with their new friends while adults could spin the prize wheel and win something cool to take home and enjoy. Let's not forget the sponsor tables where you picked up a squishy brain, another treat provided by our new sponsor Sm@rt Technologies, who were on hand to help you learn more about their IT services PAGE 8 Victoria Benda Michael Kardas Willie the Wildcat Ozzie, Kane County Cougars Dr. Kim Meyers The Liver Man The Moo & Oink Mascots Seems like a lot right? Well it was and where else in Chicago can you get this much family fun packed into one crisp fall morning all for a good cause? Due to the hard work of our teams and participants, we raised more than $64,000AWESOME work! It takes a lot to plan an event like this so join us in thanking our sponsors. Stay tuned into ALF, we have something coming that will help you Walk "It" Off with the American Liver Foundation in 2007 as we enter the next generation of Liver Wellness! Get those teams together and I'll see you again next year! Congratulations to everyone who helped out and we thank you all for your diligence and efforts-we can't have this success without your participation. our top runners who coincidentally are married Darren (17:57) and Amy Olsen (23:03). We had a record breaking 39 teams register and amazing teams won the "Amazing Feet" award: Team Bifero, Jordan's Journey and Loyola 4 Livers. They each raised between $2,500 and $4,999 for the event. Cheri Mauer was our "Supreme Sole" for the second consecutive year! She was the individual raising the highest amount with more than $4,020 in donations turned in for the event. Special Thanks to: Margaret Shortridge, Fox News Chicago, Emcee Illinois Chapter Junior Board of Directors Miss Pre-Teen Illinois ~ Catherine Olsen A bigger stage and more entertainment is what we had in store for you if you were looking for more fun. We started the day with a high energy breakfast sponsored by Jewel Foods. They provided plenty of fruit, bagels and water to kick start your day while a new sponsor, Clif Bar, provided plenty of power boost with samples of their new Shot Blocks and Mojo Bars. Our emcee, Fox News health reporter Margaret Shortridge, joined us again for the event ushering in new faces and old friends. After a quick and healthy breakfast everyone gathered by the start line to hear a beautiful rendition of the national anthem performed by Brianne Bassett. This kicked off our warm-up with trainer Don Myles of X-Sport fitness and new to the family, Miss PreTeen Illinois, Catherine Olsen. She helped us start the race after our countdown by sounding the race horn. It's not just your average Walk event, the 5K Liver Wellness Walk Run event is a power packed day of health and liver wellness where you can find music, entertainment and fun at every turn. This event helps raise awareness and funds for liver disease and liver wellness. On October 14th at Montrose Harbor, 1,000 participants, some with their dogs, showed up to help us celebrate a new location and new fun. By Carolyn O. Watkins Welcome to the "Next Generation" of Liver Wellness 20458_ALF Newsletter.qxd Cheri is both competitive and driven and she wants to see PBC erased from our future. She hopes her grandchildren and others never have to deal with this and she is focused on helping find a cure. The 5K Liver Wellness Walk/Run event is Cheri's outlet to help and we welcome her enthusiasm and spirit. When you see her and Annie on the Walk trail say hi and know that she is joining others as they take strides against liver disease. receive the honor of "Supreme Sole" being the highest individual fundraiser at the event. In 2005 Cheri won the award and was surprised, stating that she would be back in 2006! As promised, Cheri came back stronger winning the award for a second year with more than $4,000 in donations from friends, family and local businesses in her area. She definitely makes fundraising look easy and we truly appreciate her efforts in helping us reach our annual goal as well. American Airlines Astellas Axcan Scandipharm Inc. Café Caterers Chicago Police Explorers Chicago Wolves CLIF Bar Coca-Cola Damer & Cartwright Pharmacy Dunkin' Donuts East Bank Club Excedrin Fox News Chicago Gift of Hope PAGE 9 Heartland Food Corp. Hill's Prescription Diet Hinckley Springs Water HSR Financial Corporation Idenix Pharmaceuticals Illinois Secretary of State Jewel-Osco Foods Kane County Cougars Lenora's Kitchen Marshall High School Make-A-Wish Foundation Moo & Oink New Balance Pepsi Americas Pet Supplies Plus Pharmacare Specialty Pharmacy Roche Pharmaceuticals SM@RT Technology Services Snyder's of Hanover Sour Punch Special Events Management The Mix 101.9 fm-WTMX The Prime Group, Inc. VietNow Vitner's Chips Walgreens Specialty Pharmacy X-Sport Fitness Join us in Thanking our Wonderful Sponsors! 5K Liver Wellness Walk/Run October 14, 2006 Primary Biliary Cirrhosis (PBC) is a chronic liver disease that causes slow, progressive destruction of the bile ducts in the liver. In turn this interferes with the excretion of bile, creating inflammation. This causes scarring and leads to cirrhosis. Women are affected ten times more than men. While scientists and physicians have known about PBC for over 100 years, the basic cause is still unknown. Treatments are available to alleviate symptoms, but there is no known cure. Focus: Primary Biliary Cirrhosis Cheri has not let this disease slow her down! She has been committed to doing something about it and it takes shape at the ALF annual 5K Liver Wellness Walk/Run. Cheri, her husband Bob, and Annie (her Miniature Pincher) have joined the Walk for the last two years and she has worked hard to Cheri was diagnosed with Primary Biliary Cirrhosis (PBC) liver disease in July 2005. She is in stage 3 of 4 and lived with the disease for 20 years without even knowing it. PBC is a slow progressive destruction of the bile ducts which destroys the liver. Continued liver inflammation results in scarring and eventually leads to cirrhosis in the later stages of the disease. It can only be detected via a LFT liver function blood test and a biopsy determines what stage a person is in. Cheri is currently in stage 3 of 4 stages of this disease, a disease that never goes away. Do you ever wonder what motivates people to win? Is this competitive spirit in their genes or are they driven by some other factor? In most cases, we can track the path they choose to glory and while we have plenty of "winners" at the Liver Wellness 5K Walk/Run, there is a "sole" winner that stands out-Cheri Mauer. By Carolyn Watkins-Vazquez Behind the Liver Wellness Walk: The Making of a "Supreme Sole" 3/14/07 9:50 AM Page 17 Peg Intron plus Rebetol vs. Pegasys plus Copegus for HCV patients with genotype 1 who have never been treated with any interferon or ribavirin product. Two different doses of Peg-Intron plus Rebetol will be compared to standard doses of Pegasys plus Copegus. Contact: Mary Kozlowski, RN @ 312-503-0125 PEG-Intron Maintenance Therapy vs. an Untreated Control Group for Prevention of Progression of Fibrosis in Adult Subjects with Chronic Hepatitis C with Hepatic Fibrosis (METAVIR Fibrosis Score of F2 or F3), who Failed Therapy with PEG-Intron plus Rebetol To assess the safety and efficacy of PEG-Intron 0.5 ug/kg weekly as maintenance therapy vs. an untreated control group in adult subjects with chronic Hepatitis C with hepatic fibrosis (METAVIR Fibrosis score F2 or F3) to determine if longer maintenance therapy with PEGIntron will retard or reverse the progression of fibrosis, thus preventing the development of cirrhosis. Contact: Noreen Osman @ 312-503-0122 PEG-Intron as Maintenance Therapy vs. an Untreated Control Group in Adult Subjects with Compensated Cirrhosis (METAVIR F4), Secondary to Chronic Hepatitis C, Who Have Failed to Respond to Therapy with Any Alpha Interferon Plus Ribavirin To assess the safety and efficacy of PEG-Intron 0.5 ug/kg weekly as maintenance therapy vs. no treatment for the prevention of disease progression in adult subjects with compensated cirrhosis secondary to chronic hepatitis C, who failed to respond to therapy with any alpha interferon (including pegylated interferon) plus ribavirin. Contact: Noreen Osman @ 312-503-0122 PEG-Intron Plus Rebetol for the Treatment of Subjects With Chronic Hepatitis C Who Failed to Respond to Previous Combination Therapy (any alpha Interferon Treatment in Combination with Ribavirin) Patients who were non-responders or relapsers to any type of interferon (including pegylated interferon) and ribavirin with METAVIR F2, F3, or F4 to be treated with pegylated interferon and ribavirin. This study is one part of a two part program which first offers PEG-Intron plus Rebetol to patients with METAVIR F2, F3 or F4 who have failed alpha interferon plus ribavirin therapy. The second part of the program identifies non-responders and offers them entrance into a maintenance therapy study. Contact: Noreen Osman @ 312-503-0122 Hepatitis C Northwestern University Naïve HCV >85kg (187lbs study) Inclusion Criteria To be eligible for this trial, patients must have documentation of the following: "Age = 18years "Body weight = 85 kg "Serologic evidence of CHC infection by an anti-HCV antibody test (current or historical) "Evidence of hepatitis C genotype 1 infection by molecular assay "Serum HCV RNA quantifiable at =400,000 IU/mL by the Roche TaqMan HCV Test "Chronic liver disease consistent with CHC infection on a biopsy obtained within the past 24 calendar months as judged by a central pathologist. For patients with incomplete/transition to cirrhosis or cirrhosis, a biopsy within 36 calendar months before the first dose is sufficient. A maximum of 20% of patients with cirrhosis or incomplete/transition to cirrhosis will be permitted to enroll in the trial. "Patients with cirrhosis or incomplete/transition to cirrhosis must have an abdominal ultrasound, computerized tomographic (CT) scan, or magnetic resonance imaging (MRI) scan without evidence of hepatocellular carcinoma (within 2 months prior to randomization) and a serum alpha-fetoprotein (AFP) <100 ng/mL "Compensated liver disease (Child-Pugh Grade Hepatitis C Contact: Monique L. Williams, RN, BSN, Senior Research Coordinator, Section Of Hepatology, (312) 563-3919 office Rush University PEG-Intron/Rebetol vs PEG-Intron/SCH 503034 With and Without Ribavirin in Chronic Hepatitis C HCV 1 Peginterferon alfa/Ribavirin Nonresponders: A SCH 503034 Dose Finding Phase 2 Study (P03659) The purpose of this study is to evaluate the safety and effectiveness of an investigational protease inhibitor when it is combined with pegylated interferon and ribavirin, for refractory patients. Contact: Kim Sipich @ 312-503-0121 CPG10101 Combination therapy for the treatment of hepatitis C: a phase 1B open-label, randomized trial of CPG10101 alone, with interferon, ribavirin, or interferon and ribavirin in the treatment of relapsed HCV subjects The purpose of this study is to evaluate the safety and effectiveness of an investigational drug called CPG10101 (Actilon- a toll-like receptor 9 antiviral agonist), when it is combined with pegylated interferon and ribavirin, for patients who have relapsed during previous treatment attempts. Contact: Noreen Osman @ 312-503-0122 Clinical Trials 20458_ALF Newsletter.qxd If you have any patients who may be interested in participating or you have any questions regarding the study, please do not hesitate to contact Dr. Helen Te, Dr. Smruti Mohanty, or The University of Chicago's Liver Study Unit was established in 1971 to improve the treatment of patients with liver diseases and to encourage teaching and research about liver disorders. Listed below are the trials in which we are actively enrolling patients. University of Chicago Exclusion Criteria Patients with any of the following will not be eligible for participation: "Willingness to give written informed consent and willingness to participate in and comply with the study requirements "Infection with HCV genotype 1 mixed with a genotype other than genotype 2 or genotype 3 or infection with an indeterminate genotype. Patients with indeterminate or mixed genotype 1 subtypes will be allowed. "History of having received interferon alpha (IFN), PEG-IFN, ribavirin, viramidine, levovirin, or investigational HCV protease or polymerase inhibitors at any previous time, or any other systemic antiviral therapy with established or perceived activity against the hepatitis C virus =3 months prior to the first dose of study drug "History of having received any investigational drug =3 months prior to the first dose of study drug or the expectation that such drugs will be used during the study. Patients enrolled in this study cannot be enrolled in another study for either research, diagnostic or treatment purposes. "Patients who are expected to need systemic antiviral therapy with established or perceived activity against HCV at any time during their participation in the study are also excluded "Positive test at screening for anti-HAV IgM Ab, HBsAg, anti-HBc IgM Ab, or anti-HIV Ab "History or other evidence of a medical condition associated with chronic liver disease other than CHC (eg, hemochromatosis, autoimmune hepatitis, metabolic liver disease, alcoholic liver disease, toxin exposures) "Females who are pregnant or breast-feeding "Male partners of females who are pregnant "Absolute neutrophil count (ANC) <1500 cells/mm A clinical classification only) "Negative urine pregnancy test result (for females of childbearing potential) documented within the 24-hour period prior to the first dose of study drugs. Additionally, all female patients of childbearing potential and all males with female partners of childbearing potential must use two forms of effective contraception (combined) during treatment and 6 months after treatment end "Willingness to give written informed consent and willingness to participate in and comply with the study requirements A national registry of patients with hepatocellular carcinoma, which will evaluate the etio- Hepatocellular Carcinoma A Study to Describe the Antiviral Effect of Entecavir (ETV) in Blacks/African Americans and Hispanics with Chronic HBV Infection who are Nucleoside/tide- Naïve. Inclusion criteria: Age 18 years and older, HBe Antigen positive or negative, nucleoside/tide- naïve, ALT 1.3 to 10 x ULN. Exclusion criteria: History of decompensated cirrhosis, co-infection with HCV, HIV or HDV, Alcohol or drug abuse within last 12 months. Hepatitis B Hepatitis C (Treatment naïve): A Phase 2 Study of a HCV polymerase inhibitor prodrug in combination with Pegylated Interferon and Ribavirin for HCV treatment naïve patients. Inclusion Criteria: Age 18-65 years, HCV genotype 1, HCV RNA level>50,000 IU/mL and liver biopsy w/in past 2 years. Exclusion Criteria: Previous HCV treatment, Cirrhosis, decompensated liver disease, alcohol or drug abuse within last 12 months. Hepatitis C (Treatment Non-Responders, Naïve and Relapsers): A Phase 1, Double-blind, Placebo Controlled, Dose-Escalation, Multi-Center Therapeutic Trial of the Safety, Immunogenicity and Efficacy of GI-5005; an Inactivated Recombinant Saccharomyces cerevisiae Vaccine Expressing a Hepatitis C Virus NS3Core Fusion Protein, in Patients with Chronic Hepatitis C Infection. Inclusion Criteria: HCV RNA level>1000 IU/mL, age 18 or older, liver biopsy w/in past 2 years, negative scratch test to S. cerevisiae. Exclusion Criteria: Decompensated liver disease, including portal hypertension, varices, ascites, cirrhosis, encephalopathy, HCC, HCV treatment w/in 3 months prior to screening, diabetes. Hepatitis C (Treatment naïve): A Phase 4 Study of High Dose Induction of Pegylated Interferon With Ribavirin for Patients with Hepatitis C who have never been treated before. Inclusion criteria: Age 18 years and older, HCV, Genotype 1, weight> 85kg, liver biopsy within past 2 years. Exclusion criteria: Previous HCV treatment, Decompensated liver disease, Alcohol or drug abuse within last 12 months. Hepatitis C Dr. Donald Jensen at (773) 702-2395 or Katie Wherity, R.N, BSN at (773) 702-4477. (Continued) Clinical Trials Hepatitis C Virus Kinetics after Liver Transplantation: Impact of Living Donor Liver Transplantation and Pre-Transplant Antiviral Therapy Phase 2, Randomized, Dose-Ranging, Openlabel Study of the Safety and Tolerability of Consensus Interferon-Alpha (CIFN) plus Interferon Gamma-1b (IFN-? 1b) with or without Ribavirin (RBV) in the Treatment of Patients with Chronic Hepatitis C who are Non-responders to PEG-IFN-? (2a or 2b) plus RBV. (CLOSED FOR ENROLLMENT AND WILL REOPEN SOON.) Available for patients (all genotypes) who have not responded to pegylated interferon (PegIntron or Pegasys) and ribavirin. Patients will be randomized into cohorts with differing doses of daily CIFN, thrice weekly IFN-gamma 1b, and daily ribavirin. If there is a > 2log drop in viral load at week 24, the patient will be continued on the treatment regimen until week 48 Interferon Resistance in Genotype 1 Infected Patients Available for genotype infected patients who have never been treated for Hepatitis C. The purpose of this study is to assess viral kinetics in patients receiving the standard treatment with peg-interferon alfa-2a and ribavirin. The study is available for African-American, Hispanic and Caucasian patients only. The study involves frequent blood draws and one overnight stay in the GCRC in the hospital. A Phase IIb Clinical Trial to Evaluate the Combination of Pegylated Interferon Alfa plus Valopicitabine (NM283) in Treatment-Naïve Patients with Chronic Hepatitis C Available for treatment-naïve patients with Hepatitis C. The purpose of this study is to evaluate the safety and viral activity of the protease inhibitor NM283 with peg-interferon alfa2a in genotype 1a or 1b-infected patients who have a baseline viral load of at least 500,000. No liver biopsy will be required. The patients will be randomized to one of 4 treatment arms which all include NM283 and IFN. Patients will receive at least 24 weeks of treatment. If the patient demonstrates < 250,000 RNA at week 24 they will continue on study drug for up to week 48. Hepatitis C Investigators: Dr. Scott Cotler and Dr. Thomas Layden Contact Person(s): Rebecca Duke, NP; Scott Cotler, MD Telephone Number(s): 312-996-8907; 312996-6929 University of Illinois at Chicago logic factors associated with HCC and to survey and stage the potential treat ability of patients with HCC. A Pilot Study of the Interaction Among Sleep Apnea, Nonalcoholic Fatty Liver Disease and Oxidative Stress Available for patients with liver biopsy-proven diagnosis of NASH (nonalcoholic steatohepatitis) and a BMI (body mass index) of >30. Patients will be admitted to the General Clinical Research Center (GCRC) for an overnight sleep study with blood tests to evaluate whether they have sleep apnea and to track changes in liver enzymes overnight. If a patient does have sleep apnea, they will be asked to return for another overnight sleep study using a CPAP machine to control the apnea and for blood tests to evaluate if liver enzymes improve with treatment for the sleep apnea. This study will evaluate whether NASH, combined with sleep apnea increases oxidative stress and consequently increases liver damage. A Pilot Study to Evaluate the Effect of Combination Therapy of Omega-3 Fatty Acids and Vitamin E on Hepatic Steatosis and Factors Associated with Steatohepatitis Available for patients with liver biopsy-proven NASH (nonalcoholic steatohepatitis). Patients will receive an MRI scan before treatment starts to measure the amount of fat in and around the liver. Patients will meet with a dietitian regarding gradual weight loss and will be randomized into two groups - one receiving omega-3 fatty acids (fish oil) and vitamin E - and one receiving no omega-3 fatty acid supplementation. Another MRI scan will be performed on all patients at the end of the study. Patients will receive treatment for 24 weeks. There is no standard-of-care treatment for fatty liver and the effect of supplementation with omega-3 fatty acids combined with vitamin E needs to be studied. NASH Study of DENSPM in Patients with Hepatocellular Carcinoma Study of a new chemotherapeutic agent, DENSPM in patients with hepatocellular carcinoma. Available for patients with unresectable (cannot be surgically removed) liver tumors and who are not eligible for chemoembolization. Patients will receive infusions of DENSPM to reduce the size or stop the growth of liver tumors. Hepatocellular Carcinoma Available for patients waiting for liver transplantation with the primary liver disease of Hepatitis C. Patients will be placed in 3 groups: cadaveric liver transplantation, living donor liver transplantation, or living donor transplantation who will receive "standard" treatment for HCV with pegylated interferon and ribavirin for 12 weeks before the transplant operation. The study involves frequent blood draws one day before the operation, during the operation and up to 8 weeks post-op.