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FEDERAL SECURITY AGENCY
U. S. PUBLIC HEALTH SERVICE
STATEN ISLAN04NEW YORK
0fPICE 0# DlRICTOR
VENEREAL DISEASE IIESEAIICH UllOM TORY
U. So MAIII. . HOSPrTAL
io'ebruary 2, 1948
Dr. John C. Cutler
.".j.'art ado 3[1:3
·'}uc.ter'nk. City, Guate!!lala
Dear 'John:
I/a5 very:;l~d to h[<.ve your recent letter and to
learn that things continue to progress favora.b~r iL Guate~ala.
You were a (.it v...gue as to the next stopping place
for the Cutler fB.r.1ily, but as there is no particular hurr-I
we will. be able to ponder the matter at our . leisure.
The trip to Jeneva was very interestn'g. It was
sible for us to lay the foundation for international centrol of the venereal diseases. If all of the recorrmendations are accerted, 'flork will be started in a wide variety
of countries and in mny lane;uaees. The ir.itial training
of clinicians and laboratory workers will be done at Stapleten. This 3roup \dll then return to their several countries
for t he purpose of conducting further training and for demoostrations of cOf'.trol pro~rams.
FO:=!
Should it all lIIaterin.l:i.ze "de .feel GUre t.hat, there
Hill 08 ample orportunity for both your5elf and Levitan to
see as :;llch of the world as nay please your fancy. Your
abilities, we feel sure, ;vill be more than useful.
lil~guistic
Doctor Arnold leaves for Europe shortly. The Arr.ty
has requested that he co!t.e over to supervis e the prophylaxi.s
::;tudy. The material is now being packaeed and should be
avail-:J.ble for sr.ipD::m.t Ilbron.d ...d.thin a matter of a few weeks.
i;e are about to expand the laborlltory mce luore.
All of t he sec t ion shave enlarged in scope and personnel to a
point where vie no lmger have room for installing several
needed sciences as phys iCs, pathology and phannacology. iie
realh;e that some da:; physical limitations will halt further
expansion, but as long as there is a square foot of floor
space left, the ternr-"L ation to a"ql8.nd continues to be e;red..
iiarris sl:owed !!le a note .from
Fortno~'
\'r hich e;ave me
- 2 -
Februa.ry 2, 1948
Dr. John C. Cutler
the imrression that he had interposed some objection to
using serologic data as the basis for papers. I hope you
vlill feel perfectly free to use any material which has accumulated in the course of the study which you are convinced is the rr.ost profitable fc r the work and for scienc e
as a \'/hole.
I~indest
regards to all.
Sir. cerely I
J:1.• :tcf
WASHINGTON Zli. D. C.
'NR......Y'_
ADD_ THa WRGlIIDN INNI!ItAL.
September 15, 1947
U... PUILI.C: HULTH ARY'CS
Surgeon John C. Cutler
U. S. Public Health Service
c/o Pan American Sanitary Bureau
Apsrtado No. 383
Guatemala, Guatemala
Dear John:
We have attempted in every way possible to come up with a solution
to the unhappy situation your staff will find themselves in when their
September salary checks come to them minus the living cost allowance.
Unfortunately, there is nothing we can do about it since the deter~ination that such allowances to personnel assigned to Guatemala
should cease September 1, 1947 was made by representatives of the
President and ver,y definite regulations pertaining to payment of living allowances promulgated and printed in the Federal Register.
I know adjusting your several budgets to this change in policy
will be diffioult but, believe me, we in Washington are going through
the sa~e thing - with eggs selling at $1,00 a dozen, butter $1.00 a
pound and ever.ything else rising in cost acoordingly.
For the benefit o! your staff, I would like to say that the decision to cut off Guatemala from the high cost list was made after much
deliberation by the Board which had complete information on basic
living oosts. No evidence was presented which, in ~ way, reflected
higher cost in Guatemala as compared to Washington.
Please tell Dr. Levitan, Mr. Portnay and Miss Vlalker how very
sorry we are that we are unable to 11ve up to the agreement made at
the tilDe they conaented to go to Guatemala. I very muoh hope they will
find it possible to continue their interest in the important .work they
are doing.
With personal regards.
~i~ely
yours,
'/(d'"
J. R. Heller, Jr.
Medical Director
Chief, Venereal Disease Division
FEDERAL SECURITY AGENCV
STATEN ISLAND,4.EW YORK
OFP'ICE Of' DIRECTOR
VDlEJlEAI. DISEASE RESEARCH LABORATORY
U. S. MARINE HOSPITAL
sept ember
[I---
15, 1947
Dr. John C. Cutler
Sanidad Publ ica
9& Ave. Sur y 15 Calle Oriente
Guatemala City, Guatemala
Dear John:
We have just completed & telephone conversation with
Doctor Heller in regard to the discontinuance of the foreign service maintenance allowance for personnel in Guatemala. We were
unable to find any legal way of circumventing the ruling or of
making a compensatory financial arrangement. The big problem
at the monent is an ' estimate of the impact which the ruling will
have upon the Guatemala unit.
The effect upon Portnoy and ~;iss Walker can be f ores em •
We have canvassed the possibility of securing an increase in grade
for them as a means of compensating for the financial loss. This
innovation, however, has been vetoed by the Washington group. The
matter places us in a position of not. living up to our part of the
agreement which was made with the personnel at the time they consented to go to Guatemala. In the event of their expressing a desire to return to the States, we can ally feel that they are entirely justified.
At the moment not any replacement peraorme1 are ava.i1able who would agree to go to Guatemala on the baaia of the
present financial arrangement, especially in view of the fact
that any agreement which might. be effected today might not be
valid tomorrow.
You will receive an official notification of the ruling
in the very near future, if it has not already reached you.
Please give me your very frank reaction to the ent.:ire matter.
mey
·
i
Sincerely,
M
cal Director
USHS
JFM:tcw
..1ll
Dear
JOhnl~
Staploton, N.Y.
April 10, 1947.
Drs Mahoney arrived back on schedule and was to good spirits except tor
being a bi t t.~·",d. The group stopped over in ~ew Orlean8 tor a while at the Lane's.
He was very pleased with the dinner and the scroll Also the trip to the Mt8. and e
Chichi6.
i"ie does not think much of the nativ~s. Yesterday we airexpressed some
media, sllgartmaltose) and already prepared .sugers for Alice to use. Too bad you are
h~ving trouble isolating and identifying the G.C.
Maybe you have the sugars mislabeled.
If Alice has trou~le with the things sent down from here, let us know right away. He
did not say much about the Pro hun but Van was quite disturbed over the lack of
confirmation of the female donors. 1 will lee hi~ next week and will get more ideas.
Don't put on any more shows unless you are sure of everything to the public. Better
show the v1st tin~ firemen around to lee the physic'al setup and explain thatthe ,-girls
are not ready for t he study. Gives an unfavorable impression. Or else do a little
blanket stretching. It eeems ta.l that the best way woulb be to have the ~irl . on
re gUlar pay for steady work, taking on swveral guys a day, several hours apart. Also
ule both the acute and chronic infections. .it look. as 11' "Willow Run" methods will
not bewery satisfactory.
The experiment with induced spirochetal infections sounds very interesting.
the question of supplying the acute orchitic anima18. One way would be to .hip cages,
nnr~ls, etc. and you make the strains and transferl as needed.
~~other would be for
us to ship 2 infeoted rabbits each week or two a8 Yell ' need them • .ihese would have been
inocculated just before shipment so that the infeotion would be ready for use about
10 to 14 days after Shipment. Kill t!,e animal for each study, and even those not needed
which had passed beyond the acute phase and are useless for umulaion purposes .lhis
latter method would be simpler for you and you would not have any large feeding or
storage problems. the animals could sttiy in the larger shipping boxes until used, or
we could ship down 4 aages for storage of animals as tney arrive eaoh week. T"e
emulsion oan be made easily as was done here tor prophylaotio studies. use a ootton
pledget under the prepuce for exposure. detter wa3h tne area a little with plain water
before exposures. 'L'he phone strike interferes with Makin,; arrangements for the next
shippent but I plan to ship by air express 2 normals for the Colonel and ur. Padilla.
and 2 infected rabbits *hat were inocculated tOday. The.se will be marked in the ear
as normal a,nd strain or "S".
I have finished the seo0nd paper on reinfection in experimental syphilis
amd w1l1 sub~1t it for approvsl next week. About 47% of the latent animals had
complete protection by immunity to the seoond spirochete invasion.
The 3 day ax
for primary and secondary syphilis oontinues to look good. That is the schedule of
choice now and will be used until we get about 300 cases. The 40X85 is .still OK.
I am going after some of the patients treated ear~y and failed to oome baok. Now I
wish we had mnre patients on Staten Island. The Capelli's came 1n- both OK.So many
changes have been made in the war d arra~gements that you will have to go on a tour
on ret'lrning to the hO$pi tal. The system improves as time marches on. Now 881 3-D
is a demo ward tinder Edmundson. Morrison has moved into the baok room and his neVi
clerk is in his old office, n ext door. The green house will soon be ready for use,
is located Ofl' the porch by the storeroom. Dr Schnell has a lot of seedlings growing
and is examining them in all at'; ges of deve lopment. ~he is a worker. Mrs Be 11 is
with her- Bell developed a oontact derm. in sero~ogy and had to be removed.
J.'he arsenic from Hotfman Laltoche is not very good in pro work. iIIaybe we should use
.more oono, solutions. That is a trioky job to make up.
I will confirm most of this by letter tomorrow. Hope all continues to
run smoothly. Better give lee a job that will be productiv~ as soon as possible.
Mr. Harris might come dawn if the serolo~ical problems take over a maj~r aspect
of t he study. after the pro work. Also I can come do n anytiae if . ne~ded but I have
lest the travel ur~e.
The pinta rabbits show nothing yet. Looks like a failure so
far unless skin lesions develop. 1)0 you want to try some more normals-"We ca» send
if needed, Rec'd check for the books. Did you ~et the films? Need any more?
fthen I get back from Washington, I'll drop ,ou another line.
Best regards t~ you and uleise and all our friends there.
As ever.
.
c/~ r! /~ ~
,,4 .. J,~
'SI"
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Dr.
Jlahon~
• 2 •
arri",a1 in In York tor hi. apinal fluid te.t. !he letter to Gibboa•
• aid that it hi. last blood. te.t " •• n8«&\1",e he could pla to «et l181Tie4.
11ncere17.
John C. Cutler
S.A. Sur«eon, USPBS
Snc.
STATEN ISLAND.4t.EW YORK
OFfICE OF DIRECTOR
VENER£AL DlSEASIE RESEARCH LAJIORATORV
November lB, 1946
S.A.Surgeon John C. Cutler
PHS 2103 - APO 839
c/o PoatJIII'3.:3ter
New Orleans, Louisiana
Dear John:
Several letters from you awaited my return from Clevelend. I enjoyed my visit to rour home city and have seleoted the
spot in the city square where they will eventually erect a monuJIIent to you. The APHA meeting Was entirely painless and very informative. Harris and Thayer had papers and both did very well.
In a recent note Doctor Heller expressed a desire to
visit Guatemala. He suggests a date early in February. The plan
is to attend a meeting in Monterey, Mexioo, on February 6th and
7th and then to proceed to Guatemala City. I will probably accompruly him.
I keep forgetting that Doctor Spoto is permanently in
Guatemala. Have not been sending oorrespondence through him but
will do so in the future. 1 haYe the highest regard for his judgment and ability and 1 teel very fortunate in having him on the
grounds.
We regret very much the loss of the essential parts ot
the Barnstead still. It is not the financial loss involved as
much as the difficUlty encoWltered in replaoing the parts. We
will contact the makers and have the items of equipment and the
necessary intormation torwarded to you as soon as possible. Would
adTise the utmost caution in the handling of electrical equipment .
in order to avoid further difficulties in this regard.
}/..r. Morrison is forwarding some torms to be used for requisitioning supplies. Many ot your recent requests have been contained in the body of letters and we have difticul ty in following
through on their purohase. 'rhe requisition form will simplify the
entire procedure.
Doctor Arnold is writing to you in the matter of the
plaSJ118 protein fraction which you mentioned in one ot your reeent
notes.
"
- 2 -
S.A.Surgeon John C. Cutler
November 18, 1946
~~e will not be abj"e to make arrangements in regard to
the purchase of penicillin for the Guatemalan Army. I suggest
that an effort be made to arrange this matter through the Pan
We would be more than glad to act as
American ~n1 tary Bureau.
an agent in the reatter.
A shipment of penicillin is going forward to you today.
Suggest that you use it in any manner which best fits the general
situation. 1 would also suggest the advisability of not entering
into a too comprehensive program which may involve the use of
more of the drug than we are able to procure.
The embargo on shipping appears to be at an end and the
remainder of the laboratory equipment will be placed on board
ship here on November 20th. It should reacil you shortly thereafter.
As far as we know all items of equipment have been provided.
Sincerely j'ours,
J.~l'k\ey
1 Director
Me i
tiS
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1'-'_ I.lad T. D........ J.a,....'0!7
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of .-Ule vi 'h rtJP. ...'ecl ... oloclc ' ••'., ~deal __
.m1lA'loa. IIIlC1 other ' ••'lBc lUI aee••• .,.. We are ... U . . with
vhole-hear'e4 aooperaUon la \he -pH.OIl.
peri.a.
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ftI'Y.,
I. tbe MrIliDe I 811 lunD« ~OI' 'h. trip ,.
lovlllBb to al4
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i t we will .ta.. CO . ., _4 look tor th_ ..
,hat
.hoaJ.4 b. able
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oar41.1tpla. 'he _'erlal ot Dr • •nra'h. eta.
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Dear ... JIaboaflll
file .i11\a17 B08pit.al Hr. b. ha4 41f'ticnaltJ ill .-t.lIte _
.......,. eup,. of patol11ia ,. 11• • tw .-GlTHa.
!B U . . . .lac t.he _Uer yUh tll_ 'h. t.boqh' oeearea ,bat
i , .8¥ b. poee1b1. for 7011. \0 lftd"chaae 'hroup 8t.&'- t.laa4 •
-.11 01'4.. of palcll111l ,. 'b. • . .t. to •• \broach t.he JPO. I l l .
Ylat fit 500,000 1IIdt.. \he aotaal lnalk \0 , . aal1e4 VOIll4 aen ...
. . . . .ly•• Ik. ~ vUl th_ PII1 '0 CIU' aoOCNn\ her. 'b. _ _ ,
\hat. we .,._4 IfIr pealcillla. fhl. Yill I'~or' a oDll.l....e1t1.
aariDc ., bo~ \1_ ..el .0• . , tflr ~, _4 _ _ 'hi ....._ _ ••
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qphlli. aa we Itree' aa4 t.ep1Dc all of \h_ i . aut..ala Ott7 I •
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Ke41cal Dir.. '.r Joba 'f. lIMon.
I'M_ IdBAd T. D. a•• urch ltaborat0Z'7
U. I. lariDe BOBpUal
sta'.e a t.1_' 4, •• Y.
D.ar
1)r.
ilah.1fJ I
.u 7eN. r._ltar In the la.' leU.. ,hat
val vrl\\en we told about
the 11•• ttl :ul. \0 trea' \he wit • •t Dr. 1'.Je4a tor acu'. aer0U'7 p.l....
111lc. veaa., ah. hal aowa a "e:r'1 c1raaaUc lapro" ••ent. .eeaa
tha' th. true U1 haY. 'oen .t I.e nlll.. 1Ir1.
11 dUl " . "
ea.II&'oll., hat & low pla... Fotel•• ud hAIl not r ..ponded. to III1lUp1.
pl.... vaIlltud.a. hI' p!rJl101. . thlK. tha, • • 8hn14 hay. . . .
parenteral wno &al41. but U 1. l1!polli b1. t • •btaln them heri eTC
thrOU&h the Itrrq. Io'h Dr. Spo'o and t thbk that 1t vUl b • • Tf67
~()C~ Move for u
U el". hi8 thl ••4101nl it ..,1 can. V'hlle I ~o not
haTe ~ literatv. ayallabl. til th. u •• of the _lao ee148 t
that
'h. 401. cnel 1. tl!'lll fd .-1 h . f pla••a protein, hovner, 10U mtcht
checd£ with DI'. tichllr4 1111 \h t . . . . wha' 'h. a••••
If it CD ..,. . - .
talne4 tlirwp th. Mapt'al pbaJ'llaq enld 7GO. leA~ a.1. npr ••• to till.
~flce a rea.cmabl. nppt, ., \h. 811'M'ac.. tall. 1'. . .11 ... read1llc \hat
pla.... albaa1a baa b ... flalla a..no_bl. tor the re4uc\1ctn of .a.... I t
arrt 1. _&llable at th. hoapl'al 7ft 81cht ••nd • __
I hop. ,hat
it wlll b. pOI.lbl. tor 1~1 t. olt'.ln the amlno aoid., •• it will holp In
c8mentinc our r.latlon. with 'hele with who. WI .hall work h ....
lac.
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t..
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al...
Dr. !.J'" thrnch17 •• joll' hi. nat, wlth 1ft at St.'en 1.lM4 ...
appr.elato' Jour
B. 1 • •. , nch In'erea\e4 11l our a __ ..4
Coaleqw..'1I' v. are oft.'bc _ real oo.,...U . fIo_ the~.
.'''''toa.
Itllo".1J'.
I..... Iv,__ • UIP!I
Jeha C. ChiU ..
~.ap.cttal17
torwaraoa,
Jo.oph I. l'Pe'o
Chief, Cartbbe&ll 100'\0Z'
Oct.".. 31, 1NS
1Ie4lca1 Dire'.. Jela J'. IIaIaeatr
I'''.
1.1ad Y. D. . . . . . . . J.a1Mr.'' '
V.I. ...la•••.,t tal
i
l'
l\a' en 1.1_4 4, •• T.
J).-
/
Dr • • • • • ,
'0 .....
%, 1• • JIIlell.ft1"e
t, the ftOlotle4 J-ej)or' r,. Oc,o"n aa4 . .
h '-1e ,., ,ell et ....111« tho ftrst t ••t. I' ba. laMB • •1 .. proe"~
,. p' .,..,... fer ~.. e haYe ltefl1l bauen"1. pettJ
~,
tr.. aw _ ,he _~ gf VCII'k tha' we 0_ ftI'a eat, . . . 1ft \he a"~en"
., aU ...
will ,a4ul~
Y. are plaetmc
wert tho
....lad. ~ td ,he Pel \&Ual"1 ~"' ..
IIJ'. Jte:r.~
Rffiol.' Ofl1&1pa-' 01. ., OQIIpl.'e a _ h r til ataor repaln ..
_.'. M4 teel 'bont !It.-i. rea47
ao tact proctuctioa. We are .tl11 . .
ber....
t,...,
r.u, to . . . A1lteot __ I
_
'tl
,he
tel""..
'0
'0_ ..
,.tal-lIIc ....
.-tr of
........, cl ••• npUYl81_ far a whUe
-.... ,. ole. _ a larp.r Hale.
now
~hat
..-1
-.pt,-
pr . . . .U- wlU
Jt.. . .
'he
.u1.
! .. 7fIU 1.., 1."er :roo. aUl'!d a})otl' the.., All' ftelt. !Ilere ar.
1& Iaa'..al.a. . . 1Jl laa'tlUda Ct ~ .It OD. at San
!he aa11
an4 npplt.1 .. e fiCMl la replar17 oaae a nek trOll PMMa. a4 'here ...
In'eca.l_. ulObacblle4 nt.a!l". .... P.r.d JI'd7 \he . .d.tat Uiet of
the DlYld_ cf 1001.., 1. . . . .ow .a al .. 1.'....'.4 ta
tho . . ,
,. aMp ••• .appl1.. ...... . . haa an'..'. ' . . . . hi. 4lybtOll ..a will
. . . ,..., . . OM " . . . that 78\1 0_ C-' 1a '1iUb wlUL hta at, ... Iw_"_
.15 wba ta. will ....
apia.
10...
we
.'be
u..
Coal' 7 . '1.... lad. '0 "H, to .tart, • ltlal* f .... n which w.
k.., 'h. roo.." fit 'h. qphll1Uo paUeD'. v ..t04 b7 tho 1 . . . . .. , . If
7 . baa _--.1 hIaIlr04 , • .,... . . .
'h.. W. 8hnl4 11k.
tho•• t ..... ....
It 7. eu. .., a
_lilac
100 r ......
7- ~, pu'
1a u.. . ., ___.,. If It . . . ., It. '--alA. . th... ".
0_ . . . . Hr. a' ..,
fer a TeJ7 k1cb prto••
t.
0__ltb.,
...
'00.
alt_,
'0 ...
'b', _,
T_ _' I . u.. n.t,. of the nrlna other lan.UC.'.... %, vill
h "WI aoo4 \0 ..... ' __ I aD4 a real "t.al•• \0
work. IN' 1\ vlll
,..o1tab~ r~. a' 1. .\ _o\Ur , ._ _ the a' tho YfIq . . .11 .. , 'bet.re
vlll 'b. acJl .... \Ma 'lla 1a1t..a'ft7 ,. , .. u4 hD: . - , .
'h.
'Ur.
ltu_.~,
""1OU'a1~
o
torw..teta
1M. I • .,ot.
~.,.t.lt'. . I .., ..
. . .
Jolla C. 0.'1..
I.A........... tJIPII
STATEN ISLAND•.ft.&EW YORK
Of'I'ICE OF DI RECTOR
VOCEREAL
DlS~
RfSEARCH UIORATORY
U. S. MARIN: HOSPITAL
$r.
October 15, 1946
Asst. Suraeon J.O. Outler
PBS 2103 - APO 839
c/o Postmaster
Dear John:
We were more than glad to have your note of October
9th. The items of heat controlling equipment whioh you mention
are being purchased and we will forward them to you as soon as
J;lossible. Between the trucking strike and the maritime strike
the harbor of New York is stUl practically olosed and we are
unable to obtain any precise information as to when the acoumulated cargo ma:,r be moved.
We have oontaoted the Army Transport Service in regard to employing that facility in moving freight to you. We
were i ntormed that the Army does not maintain a fl~ng field
in Guatemala which was contrary to my impression, BS I thought
that the Air Corps had a field in Guatemala City. The Army did
have regular service from West Palm Beach to Panama at a cost
of 60p per pound. I wonder if you would check on the situation and 88 to the possibility of moving material up from Panama City to Guatemala City.
\Ie were all pleased to learn that Joe Spoto is returning to Guatemala Oi ty. He can hardly fail to be of real assistanoe to us as our work unfolds. I do not know of any man 19ho
could be more helpful inaLatin American country than Joe.
Your show is already attraoting rather wide and favorable attention up here. We are frequently asked as to the
progress of the work. Doctor T. B. Turner of Johns Hopkins wants
us to check on the pathogenic:Jty in m.an of the rabbit spiro Ohete j
Dootor Neurath of Duke would like to have US tollow patients with
his verification procedure; Dootor Perren and probably Doctor
Moore might drop in for a visit after the first ot the year. We
have told them all that the laboratory 1s not oompleted as yet
but when in operation we would more than welcome visitors end insi>eotion.
Sincerely yours,
J.~mY
1iedrU.~irector
USPHS
Jl!'M: tow
"1." •,",.IO~ ••,
I..,
·011 ..
0, \1 ''t-. pe ""PftI .fill
-"III IqA1nlI ttRI • ' - ....t d _l ,tMO
.a+ao
..
,...........
·0 - . ,
D.ar Dr. MahOIl.,.
Aa 'her. are
.c..
DO 11brBrJ tacll1tl.! here \0 oh.ck on .o~e ot 'he .tat •• emti.
8Ild . . . , ova JourJL&l.. 84 Dot •• haTe Dot arriTe4 'her. are
ot th ••• tipl".'
that are not &Cev.t. _d .011. that are not &Ta11.b1. nch .11 'he report. ot t.
r.nlt. ot the .tu41 •• i . the 11.1. J:rrq p1lblhhe4 111
tora.r prot,•• III
ea. fit the I'M.' •••••IAD'
ot the _trleD Icra.rnal of ITPhllt..
azL4 'enereal Dhftalle.. It 1~'hiDk tha' i ' it "...'h doiae aa,th1D, wi 'Il. I 1hftl.4
much ap~J'eel.t. 8D1
aAaltio. . . . . . . . . . .tlaa. wi'h whlah I
aak.
ch.e.Dce1. When t1nal17 appro.... "if ~l tho•••ec.'I~ ". vll1 'ro.l.h l' ha.
u4 a.'bllf.t i ' ,. th. leere'., ot 'he l.cal 1.41.&1 l.at." who we" U.
_'eI'.
.oor."
.at.
chaDc.'.
"-"'Ilea.
hod a note about procr.... taw pl_ber. are flAl_tac DOV • •1 thell' orictal
vork .vall latiltectOI7. lna" the 010_111& of clM.vare t. u4.r v.,. ala,,1 haTIO
hop •••f rel11ac 1001l.
lb.. vhole
~~ ,e.d thell' 1'1C8I'd••
".dJ.
If the vlV'. Dr. hed
the &II1t"eat ehlef ef 'he If.Tilton of 10010n'
h here tor e. tw v.fOk., .t.,tq vtttlre Vtl ere, We were talkiac ..bou' ,.•• ot til.
~ trdlpOl't l.nloe which lei. 1'1 .... b.th ., Sea lOll . ., h ....... at"
".,a'eaa1a ., 1to~ f1f vhiell al'l.. 'he V.I • ..,." hal atr ' fl.l ......4 b•• aU. 'h· .t
hh aiT1dl:'D hal uoellen' eMit ••t with 'h. arlit .0 'he' wh_ hi ~o •• back h.
,,111 .. ee whPtt 0_ b. 4011e IIboa.t 'he ......... all ht. crOUp i. allo illter.et.a in
uliD& thf! fAc1l1 tie.. ttmt. wh .. you nen CO to W••hine'. YOIl Iltch' let ill tent_
vi tb hia. a! he "at .. h. v0aJ4 . ., t. weft OIl t, flit .oon k. h. C." back ,
It • •, "e that the OIl. who
'0
wall no' int....e« .... t. 'et&«
helpttU. or elle 4t~ Dot JrD~ _Oh .bft' 'he 41~ot1Uoa of bil al' ••
'alJr." "eM
1I."e'.17.
i
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STATEN IS~NO~EW YORK
OfFICE ~ DIRECTOR
VEMEIIfAL OlSEASE ReEARCH UllOMlOIn'
U. So MARINE HOSPITAl
Ii
Oc'tober 28, 1946
Sr.Asat.Surgeon 10hn C. Cutler
PBS 2103 - APO 839
c/o Pos talaater
Dear 10hn:
We have ~t learned tbat the Kari tillle strike is oYer
aDd that ships will be moviAg almoat ismediatel,. We will make
eTer, ettort to get the remaining laboratory equipment aboard
the tirst Yessel goina south.
When that is accoapl1shed we
will make detinite plans tor Doctor Harlow and lIiss Walker •
. Not much new up here. We are to reoeiTe an award tor
the syphilis work at the CleTeland Ileetiag ot the APHA. The
swards are made possible by the Lasker toundation.
We haTe at lut encountered a pathologist who appeara
He ia a BuD8ar1an
gent18lll&ll wi th an U1lproDDWlceable nama. He is at present at
Yale in the capacity ot research assistant. He haa an II.D.
degree aa well as a Ph.D. in oh_istry. Se appeara to be able
to think along patbolo81 linea aDd ia not II oontirmed "aorpholoe;ist". We will endeaTor to secure a reae"e ~i"ion
tor hia.
to haye the qualitioatioDB whioh we need.
The work wi th the anions appears to be Mkin8 prosresa
How IlUoh so OILD only be Ju4Sed by the data
in the record books aix months trOJll. now. At least it ahoul.d tell
us whether or DOt iIan1 ot our patients are still &Oing to aea and
the adTisabilit, ot makins turther ettorta to tollow those who
haTe o~d to other occupations.
aDd may be trUittul..
Please g1 ye ay kindeat regards to Doctor Spoto. I cannot help teeling glad that he ia to reain in Guatemala. With
his gUidance suppl_enting your own, I am aure that the stu4y will
be a sucoe88.
S1B~OTOur••
l. y
Jle41
uama
1FIi:tcw
!l;
Director
•
STATEN ISLAND.7NEW YORK
OFtlCE OF DUlfCTOR
VENfRfAL DlS£AS£ RfSfARCI1 LABORATORY
U. S. MARINE I10SPITAL
sr.
PHS
c/o
New
Ootob er 7, 1946
ABst.SUrg. ~ohn c. Cutler
2103 - APe 839
Poetmaster
Orleans, Louis1ana
Dear
~oh.u:
I have been out ot the ott10e eo muoh reoeatly that
1 t w111 be neoessary tor me to aDBWer portions ot yOUl' last
eeveral letters at one tae. I surely hope that I w111 be able
to keep our oorrespondeDCe IlOre oompletely .arrent in the tuture.
1) AIJ regarde Dootor Harlow and lI1e. Walker. we oaanot eee any sood reason tor turther burdeuJl& per d1e. tUllde w1 th
add1tioDlll personnel unt11 the laboratory 1s 1n operat10n. Both
Doctor Harlow and K1es Walker are urgently needed here and, aa tar
88 can be v1sualized, they would aot contr1bute sreatly to the
Guat...ua study at the pre8ellt Btate ot 1ts develop!1ent.
2) The eleotr10al equiPilent aooord1nS to apeoit1cationa
confirmed by JOur most reoent oablesrUl w111 be purou.ed here and
Bent to Guatemala by the t1rat available trauportat10n. A aeoond
liar 1 time str1ke 1s in progress at the JIOJIl8nt and JAr. 'Eyte 1e rather
p8s811l1stic as to the ava11ab111 ty ot sh1pp1ng spaoe 1n the .ear
tuture.
3) The paper whioh ,you torwarded w111 require the approval ot the Surseon General and poss1bly the State Departaeat
betore it can be published. We are not authorized to do aore tile
8ubmit an opiaio. as to the aoouracy ot the .aterial oontaned 1A
. the paper. The subjeot matter which you bave oovered 1& to t01'll
the basie tor one ot the prin01pal papere whioh the laboratory
w1l1 prepare 1t, 88, and when the tollow-up ot the peai01111n
treated pat1eat. 1s sutt101eatly oomplete ·to warrant oonolus10na.
In i te present state I do DOt think that we are j uat1t1ed 1n drawing any oonolusions trCID the zatedal at hand. It would 8e_ to
be a mistake to aske any praaature statements 1n a tore1gn medioal jourJLal.
4) The program ot the Guatemala laboratory haa beg
out11ned and the tunds whioh have been made available are tor a
spe01t10 purpose. Any d1sres810n or any add1tions whioh will lead
to a diss1pation ot tund. or energy may he responsible tor tailure
ot the ma1n line ot endeavor. Unt11 the venereal d1sease work ia
organized and under way and knowledse obtained as to the adequaoy
ot funds aft11able, 1 t would appear to be hazardous to embark on
- 2 -
Sr.Asst.Surg. John C. Cutler
Ootober 7, 1946
aDy other torms ot researoh. It would be most ditticult to explain to the reviewing cOJlllll1.tte. just where1n a study 1nvolTing
the use ot the electron adoroscope or radioactive materiala
oould be considered as a.a integral part ot the basic study tor
which the funds were made available.
Sincerely,
~.~~
J,{ed~reotor
USPHS
., /
Cetober
• .ueal. DlI' ..,_ Job
3~.
1141
r ......
'.J7
"at .. tl184 ,. D. . . . . . . . J.a' ••
~. s. MU'1ft • •..,l'al
St8ten t,1 .. 4 4, •• t.
D.n'
1)1'. .001Ulr I
,ft
It " .. pod to taow ,hat
are \ack 11l 'be J.abOl'a'frlT apt-,
I l'UCla. lb..' ,011 ar. 1'1••••' that ,h.
'rip' of t11. laat
aODth 11 ., .. ..t.
:. .
\
here
_'.11.11....
,qaz
fb.er . . . . . . . .&1 pol.,. llL
l.'ter of Oc'olJ.r .,.
Ml the 18th, whioh J ,bcml4 11k. \, UlCU".
1) 1ft
picht Ab011' Dr. Barlo" 04 .h. Walker.
pr.UG.'.'
11:1"'
....
*,c:tIl reMbe'
I
,., r .....'
tor th• .,...
n 'he bolt". t cw11 put centU..... ill \he
onU-ac'.r'. YOJ'I, ho' I _ crab.Q117 leanllnc ,hat th. 1'1'_1 ••• t .
4.11?0J7 .., •• Hr. . . . . .ual. .l ....
2) !ha'IIc,.. tv U'HDClDc t. '"
b . . . ., hal,ta1.
,h. e1 .. trloal ....'p• •,. l ' will
3) !he pap_ whloh I .....1"... baa It_ • ..,1.'. r .....4e1 _, I
AI . . . . . l' 1. \rpa4.
vlU • •1 l'
4)
'e ,_
..,.M
... for tho vork wt'h Ir. Cowl ••a a • __ with raUo ...1....
• 1 __'. '!a• • vill b. . . III..Uoul
tay.1TOl. !M JI• • •t t .
b1a . . . . . hu. 1, 'bel. . . . . . " the ...'...,_ .....___, _, al_ tJaomp
Jr • .,.,..... \he P• .-.t. . lat'''' ~ .. \ltat wha' ...... ...tr 1l. 4e..
vl\h 1l. vil1 b. aua _, vil11. .1. . . . " lU,l. . . ._"ltv• ., U ••
• 'h.. " h1a . . lit- .,.
.eal. _......,. ap"', ,.
beela ~.. ·Ift- ....lect.oa1 , .." _ uall
Oo,.b_ _ • • •'UP . '•• \ 'Ile vat . . . . . . .ti_ 1 ••_
pl".4. IMP. . . . a t.., nppl1.~ wIllell k. wU1 11k. ,. . . . , .., "" . .
.. ••oa &I p •••l\l..
IIpplll4et.a
1Ir • • • t-07
D. 11., 1.
'.41.. ,.., _,..
• plftU .... Ua . . . ., .......lpeo1a1~
• roJ'" of 1.... to~
t . tu Ilnt. . . .
s.a
a ••M, ., h..., n\ber ""be ,. aOY.. \h.
a ••1... fII ..u •••, t.U..,. •
.. • a' I • :II: 3.. , " : I I : 1"
,he """'Sac peo •• ,
e . . .' l1'ala .....11.
ecUp.'.
n ......l .....ft'. . noll . . . . et. ,. ern- 1&1». . ..,.
l ' • •, \ • ., a 11'''' ,. vitll.,... the ape... ,. ... _4
a. 41• •' . ahMIli ... ___, 1.... aa4 tILe k.s.b' 'u ....
1 kUQ
rala.
.-
~
-IIt , ...ibl., on11 ~_ ..... I eo of a.1l t .. tt.ac ..... Ule vit. III
• • ", \h. "aft i. F .....' .... u. ,..io1_ it "'." auI. . t • •_
h.. t . a.1l t _ _ • It p •••l.l.......
_IN. t.a ,he Idd.,..t • •
val'i. . 1a \h.
he abIw. . . .
t . . . . la tILe
t.a1a"."rr. I' will all. b. III " U p , • •at la 'a' Ihlpa.' laoo
( • • til......., PIP" .... e.. i . . . trtw"1IC vat_ i. 6. J.a\'''-''
.0 that •• haY. ,. keep • _ttl. of &e.'111" _, .. tor 'U .Uft ..
.... l ' vlll al•• ). _ . ., ... , ...... ,. til• •
100 ..all
J.a'._..,
.... ., .... t .. ••• ., the
,II.
u- ......
La\er.t.., ,...
-.1.
hi,.., ...,
!'lln.- i . ..1...... " " ., tit • . . , • _ _ _ t alt. ., . . . . . 1"'~
dl of t~ . . . . Mr. t.a the efn. . . . . . .t . . t. Dew vJ&nu. W ••~,
.,,It.. all. t. the PII • . , lat__t l . r . . . . . . thi. vlll h "'.,
muala appr ..t.te4.
I rlp-,' 'hat all . , lettll"l DOW haY. to b. "eat.n« l.tt•• ', . .
I hop. that '.tOl'I acsh lo~.. % rill be J'~OJ"U1l& ,.e.l pr.,..••••
1uIl_.
Dr • .,.,. r.\vIle4 fr_ ~• • 'at ..
We 1, "'., ...i . . ,.
help t. ,........., , ••11'1. wi" oar PO..... ad hi. aUnl..,. udnco •
.. ".ll .. b1. esp_t_oe will 'tie real ",alue tn lnCJ'Met.DC the _ _ , of
vel"k ,hat •• alJll 4a.
l,.
,1ac ...
leba O. Ca.U ..
...... . . . . . . VIPII
ICO/mTIIr
iKr.,..
JredJ.oal
Joha 'I. lab• .,
B'a\ela 181.8' T. D. I •• earoh kbora'ol'7
O. I. Marlne IOlpital
Staten 1.laD4 4. I. t.
J)NI' ])1'.
JIahoD.,'
leu lnt.. of lep'.'- 20 1'. . . ., . . 1 .., .,..1", _ , ".. ... 'al1lll'
ald
hear fro. ;yoa.. !'he J)rGpa8a1 t . 'he ltudl 01 ,h. 1'01roehet. natCN11
.0Wl41 ?ery bter.IUDI rmd t hep. that 1f3tl CaD CI'!l'1'7 it Kant.
'0
You.r l10te eltout the study ot the , 2 hour .oh.dule 18 rather Ultvb1q.
and 1 hope th~\ lrJUZ' tollov-llp plan "f1l1 be p1"ofteUn_ t"lM ",lenniol b ...
to treat udne the 2 hour .ah.d:',11~ ud~~ 40.000 UJli'. 3ll.t 8.8 at Stet8ll
1.lM4. _(1. t.d that " . . •hall be able to cat YU7 clo•• {allOY-up oa IIU'
II"ctap of paU.,.. It ,h. ,eIllclll1n wh1ch "fa.• .-oha••, for u •• her. hal
aot 7" let' \he Laboratol'7, 1 will ~rtci&t. it i ' coal4 be ~&oked into
_ell alh ad ....
aae under (Jeye"l'1ma' frat
'he DO MaretJI. It i •
., f •• l tba.\ part ot our wec •• " 1n eat.n!.nc cOIIpl.'e cooperation will 4-s» ....
~oa ....iDe lip • • • vea•••, pr0ll"~' on • tOJ"aal lOal. which 0& be dca.
in the IUl t~ Ko.pHd end in the!'!'" 'PzoilO'ft ho~1ta1.. !hh we ,ha.l.l do AI
'0
'0
.oon aa our penicillin Ar~lT.I. It baa b.~. th~ te~lln~ o~ bo\b~. &pot.
Dr. rune. and thp. othP.T men h~r. lD tbe office that v• •h~ll haYe '0 &e
the l'ropb7lactic studt .. vory g!"rauAlly, 1!IIJlc! '0 40 all 1.'bor~tol7 verk OIl •
b~d
tDlall Be.:.'.! e treotsent pr0l!'"m;l.
I.
I _ gl'o.duallJ' ls8I"111ma th~ a.aIl1D« of the wol'4 tn..'ration. th. won
1n the laboratOZ'J 11 DOW 0.,,1.'14 GO.,' t . pat.aUac act erd.riDe aI c_eo\toa to a ""81' npp17. ".~••ow b.lac vatU. . alao ... a v • • tep
b. _ " "" labOl' . . . . .'.rial 4ltftoal \t •• han h.ll i t -ap. .0 tha' v.·. . .
~ . . . t. " ' ' ' ' M4 ,. c l _ . . . . . , , ••11\1._ W. haYe hope. that de-··
ClodtniletOl" vill '" • .,1.,. v1'h hh werlc ~ the a ' fit 'ht8 week. T.d _ _
I ce' 'h. tU.' , _ fII . ,. . . . . &"a11ule in OI1&".-1a ad alo•• wi\b
th. tall ~ _I re4Mlac YalT. b the -01. cl\7. It 70U Cd _
ta I .
fork \h. . . . .H1'7 Tal? , . . . . wtUl • h •• '.lU • • nea. a re4uotq ~Y.
u4 )lll"eot••i - ••, .. , _ atp' ..cl••• i ' ill 'h••8\ Uip,-' aa ". ... tva
'Mk 'h• • • \hat ". haT. t • • t30.00 OI"eUt. ft. 1M Mre •••, 11. tll.OO
, . 100 l'b•• , 1t 7ft haft .... t. tla.
alJ'..e, ltoach' 7oa. aa '. ._
, ... U 1"\ ..,. . . 'hat i ' vill be & ••nDel t. a, .'lluvi•• va ...
nb ......t 'botU •• et ... fros a lDcal tOOJ'ce. W• •Ull al•• be .-a. 'to
all of th. carMa 41ozi4e tha' we D.et, h..... ezo. v. 1ha11 ••04 t-h. ~•• .
• qui,..., t .
COll'atJa...
'hi. ,.
i'
La'ora'.,
'0,.....n•.
'h.
'\114 tA 'h.tr own ltAnIH.-' I
'0 ..e ta a••aft
hn •••bml' 'he fir.' .,
!h. 'ort• .,. are ~ .ow ."'_'ab~
,I'•.,eo'
loY_,,-•
haY• •
at ~illC Al.
. . ar... her. .....
th.ir 'b •• ,
recuta ,. 7ft.
I
1••••17.
STATEN ISLAND.'\EW YORK
OPP\CI: OF DlRECTOII
VEJIEIt£AL DISEASE RESEARCH LAIOIIATOIrI
U. S. IIIMlIE HOSPITAL
September 20, 1946
B
s. A. SUrgeon .John C. Cutler, USPHB
PHS 2103, APO 839
c/o l"'ostmaster
New Orle8Jls, Louisiana
Deer 3'ohn :
We have your very enoouraging note ot the 17th and are IlOre tball
pleased to learn ot the aotual progress whioh 1& being made in the developm.ent ot the study in Guatemala. We are glad to kADW that IIr. PortDO), haa
tOUM a su.1 table dwelling plaoe and tba t you w111 be, we hope, oQlltortably
situated in the near tuture.
We are trequently asked u to the progress which is being aade
in the Guatemala study. IIany people appear to be aware ot its existenoe
aDd interested in the studies ~o be undertaken. Recently. Dr. T. B. TUrner
ot J'ohns Hopkins Haspi tal. approaohed me wi th a swstiOJl that we endeavour
to deterll1ne the pathogenioi t)' ot the spiroohete 4iL~'in the human.
This would not be a dittioul t tuk. I suggested the advisab11i t)' ot ut11izing a treahl)' isolated strain in order to avoid any possibllity ot oontamination. Doctor Turner would gladly carry this out at an)' time we
indicate our willingness to go ahead with the work.
We are liON than oonoerned over the penioillin work here. A
tinal anal)'8is ot the q 2 hour:"schedule tinds the tollow-up to be ao
JIleaser that conclusions ot a.DJ kind are not possible. Although the
results appear to be tar superior to those obtained with the lower dose
aohedules the nwaber ot obsert'ations is 80 t .. tbat the tindings are not
statisticall,.. valid. We are now endeavouring to work OQt an ar~ment
with the Coast Guard ~ maritiae unions whereby all sailors whoae naaea
are posted by us will be required to olear with the laboratory betore
signing on ship. This would give us a rather drastio instrument to use and
one whioh would probabl), not be suocesstul it continuously _ployed. However it aigb.t serYe to save the penic111in work tor us.
The lihipping strike is still in ettect, although there are soae
eTideaoe. ot its approaching teraiAation. The balance ot supplies tor )'our
laboratory should aove torward shortly thereatter.
With best wishes to Mr•• Cutler aDd yourselt tor a very pleasant
sojourn in GuatllllLla, I reaain
Sinoerel),.
1S1t~1
K~
Director, USPHS
.....
UY
"~
On.'" I,
lt4l,
••41oal DU .. , .. leba ,. Mabo...
l\a,. I.la.. T. D.......eh 1.&'b...a'.1'7
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h va. wi"_ 1. ",11 • ..a _ ••1.'.. "
tn
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uke4 ,.
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27 •
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•• , han.. .... aut
Ibvt.Ilc tU nnl.,. fit 'h••••h1" _et .,
.u,.
'he 1a.....'..,. t"Ae .,. .
..
leao.'U'J' .. that I . . . U
lpaa1e1l.
"\'~" all WIll' tll.leao.'.,
fit Ui. AnMl.U. . . .4 1t he ewJ.4 Iuw. l ' ,. psblt. h ,he .....la..
1••• III Ule IUt
, . a.uNlleuul vb1eh . . . lIt.M M • • ,~. l ' ...
O.'o'ber tIM l1tll. I ... -.ell .uprl....., the t-..." ' .... ut .. that l'
Wftl.4 hay. t . . . . . .,
t . ,"'" lIfPI'eYal. I _ - l••lac 'h• .,ula
• . " atU'haa'el:I I JaaT. Ml ............ ., ertclul _ I t . . J _ I'Hr• •1.U.. It _4 IMalt baY.
t.r . ,
,hat
tu , ........ la panlnl.. tflr U1e 1.t•• ,
\b.._ .
'0 ,.
,ft .., ...
t,1'..., ,..... ,. _ ,...,..., 1'-.1,oUac'.
• .,
_
1'.'Ill
,...•••'ka'1Ip-,.......
'h.
""'1'...
I . ..,... ,hat 1tT \hb 'lao , • •
la .t-'" ,. In.. ' "
'h. preer"- 11l til. 1 .....' . ,
I .-.1.t Uk, "
'h. vak of tuta11a'l. 1. ~....u.c al..,17
....,...,. I . .
nt..
Bat.., _ 1& __. . . , til. pt_. . . . .
al •• " . , ,. ,rle•• " •••, 'h. ohtef a4 t. l1.ft.. 'h. wrk. All.,
th•••• _ ........... 'YB7 _81... ,. haY. 1l. .. ,. wwII:: at ". h.,. that l'
rill la. an ... 1. . . .
\'ul • .,11. . ., ,.,..'1. . . . . la. at.....
'aki1lC.
'Y' hal • ohau. ,. b1k , • . Dr.
Ip.t. . . h. pi4 that Ia. vat., to ••• 1- wn lD ...hl...... t .. the
htrln OOD.t. . . . .
All .t the
P'''' h.r...... \It..lr ld.....'
.. ee.t. t. , ••
11"".17 , .......
I.b O. o.U ..
I.A. tv...., tJIP.
loci.,
.
.~'_'b ..
leba ,. Mu.n.,
•• 410&1 .1r.c' ..
I'a'_ II1a4 '.D •••••U'eh
lJ. •• llaJ"iIl. 11• ..,1 tal
,'at_ 1.1. .4 4••• T.
hal' Dr.
JIah_.,
30. 19M;
~.ra"17
I
la prmn. 1." .. , I haY• • •Unea ,hat ... D... I. Owl,. 'h.
p-,.1c1., 1. o'-r•• • t 'h. «relat.. at the caraect. 1••'1'.'.,· waah1.,t ••
va. werklDc ber. ,.111C ••••tutl •••11. . .cheouot-Il.. I. 'h. eeu •• • t
hi. ri.l t her. u _.... Yf117 mch 1.t .... '.4 ill th. p.d'b111t7 .t vtrldJlc
her •• 'Putt1ac th• •1.'1'_ aler••o.,. lat. aotion. d.lng tal'th.. v.rk ..
8I1.ohocer.laa1. _4 4_be ••••twll •• v1\b ,.. Jr. J1_eld., ,he Ktat., •
• t Jlealtla .., "'b118 W.ltar. 11 WJ'lUac h requ •• ' thai nr. Owl. b • • • t
her. ,,'·vert witJI. 'h• •1....eep. u4 " val. . . . .
lb' • .,.M
hat plaDet. 'It.t.... h. 111ft. " r.qtl•• t ]d. ul1P1l_t " •• tv'll..
• 'lIU. . . . . .oheo ... 1~1.. w. talk.a eY.r th. pol1'b111U •• et a
et
th. l)re-pb;rlaoile e • . ,..... the nUtae .t vblGh 1 . . .cl...... It 7ft are
11l'..nt., 1. MI'T1lUc .. thl .\1U1J 7ft oa wrU. " Dr. ""'" • •4bc ~.
vrU...,. .t 'h. pr." ..' an4 Dr. eMil. ~"" thai l' vRl." b. vell " •••
Dr. ~. p ....D&ll1 AI well .. Dr. Oov1e III. 7f1Q7 aert 'r1p ,. "uh1,,-••
_'ly...
.n."
III ..t . ter Oarn..1. t . . .,lp Dr. O.vi. to ach a pr'3oe' 1'..,.,." 'er
vUIr h.r. will haY. ,. _ . Ir.. IeTera1 .ftJ'0.. ... t.r .",ral
prlp~l_Uo .'u!7 vw.1.4 requ~_re a17 a Y"I l1Ul • • t
hh ila. n11e hi. bIp.riut worll:: vnld be .n the .leotra
wh10la
h ••.,. 18 ••• • t the Yf1r7 beet ..,.. _... It he .bou14 r.tua t. WG'k
h ... th. . . . . well be a
t. stu"1 ••m. of the 'b1DC'1 1a wh10h 7ft are
iD.t ....' .......1. . 'h. 1••
\bil. ... 1JIb,ar- weu14 'PZ'oba1t~ va' "
haY. a _b.. • t h1. 1'... werk.a ... Dr. Owl. 1'. . . . .4 " Wuh1. .' .
7 •• ' .....,. 1..naa hi •••1«. . . .'er h ... , _4 ea14 u h. lett tha' lt th.
1a'-a"17 i . la, ....., ... we aeala v.sell:: ta.t , ••• , n.r 1'....., 1. 'before
h. ce" t1el 1lp la alV vuk. _4 he aa14 faJa'heraer.
1. 7.v 411ft••1 ...
1 t wal .. b. v.ll ,. _..t1n that h. aa4 I art ...... Jlt., ..a •• Wl'k
per.oull1' -... tha, 1 vnt, 11k. ,. wert ,,1 th hl.. I' •••• ,hat 'h. aMl1"
of taU Yic1ul ,. we~k
11
v. haY. bN_ 11'f'l1lC 1_ ib•
.... __ .. d . .1 t.r tMll' v... •• that we taew .... _"th.. v.ll.
bi_ "
pr.3-'.. 'Iw th.
.lor",..,.
.bae.
,1"a_',
'ha'
'''''MI'
,,,.'liar Up_"" _,
Dr..
!her. 18 ..eth.r 'hnch' ,. keep 111 .la4 It ..4 vh.. 7ft •••
Oowl •
Dr. Cowl.", . . . h ' ••• , ... 1. tu FulMeUft lJ_101.1U- weft
,hat l' .lah' , . p •• dbl. tor 'h. J.a'..a'~
OIIr1loc1. , . . .
o • .,..aU•• wen .. 1t.
.... flift.
all"
u" •••
"1"
11••orell 1SQr.,
lela O. ~'l ..
•••• Iar..... UIPII
STATEN ISLAN01tNEW YORK
0fPlCE Of DlII£CTOII
Septe.ber 20, 1946
VEIIEIIEAL IIISIASIE "[§ARCH LAIOUTCIIY
u. S. liMINE HOSI'fTAI.
s. A. Burgeon John O. Outler. USP.HS
PBS 810S, APO 839
New Orleana, Low,81ua
Dear lab.n:
~e BAL tor the treatment ot ar.enical intox1oation was reoeiY84 tro. Dootor Eagle and has been torwarded to you Tia the Amr Postal &trv1oe. Another
ah1paent ot a .Wlar uoun t will be .ent nen we••
The pure ohemioal
requ_te4 tl"Qll Bdaewood
USeDal and . . .oon a. it 1. "OeiTed it w1ll be .ent to
rOUe It th... paoke&- uriTe sat1staowrilr••e .hould
be abole to Mnd a J1Wlber ot things the a.e wa,r. !}he
1Datruotions tor the u.e ot BAL are enolo.84.
BAt....
We baTe .0Ted ato the lIospi tal, Uk1na the
recorda
ol1Dioal taoili ti.. to one ot the t.Ter
therapy rooaa and the 014 cUAie roOli. So now Doctora
Wright and Barla.. DMJl and Al haTe their ottioe. OTer
there.
-=
0
I am enolosing a letter tram Doctor Barka. . .
requeetina retereno.s oanoern1ng urethritis ..sooiate4
.ith protozoa .easea ~ twl&i. It you lett. list ot
.uGh reterenoe. here _ shall .. e glad to look them up
tor rOUe lust t.ll U8 where it i8.
SiJlOerely,
~.
R. C. Arnold
Senior Surgeon t USPHS
Aaaooiate Direotor
ROA:hIlt
Enol.
Me4.loal 1)ireotor John I ••abon.", UBPII
'~er.al »t ...........ch t.bor.'Dr7
11. S. Marine H08pUal
St8t~ I.l.md. ~ ••• T.
v.. •
II IlOW, acc:or41ac to ., oalcul.tio•• , • •bou14 be back fl'. 70U'
.acaUoa, I hep. 'hat l'
pl . . . ., aa 1".'~
w. t ••l rich'
., h.. her. ",. 1lov. are 1• • •lac the laacu.re, Iliac! llke the
_h.
How.... tl.41D« • )wa •• 18 • proll_. .. 'h• • 1. _
.hen....
and the reah ar. . , hlp. W. h&9. 'III., Uleache
1. . 'u4 haY••
10•• hep ••
ea.. cl"
an'.
'0
0'
'0
!her• • • • _bel' et \hUe. \bat I Un.l4 llk.
rtrport '-ea.'
oar pflp'''' her.. Mr. Per'a.,. art....... . . . , IIOI'Illac a4 18 eOllf... ,ab11 ••,tleA paM. . th. fla41 . . ., • . . . . . ft. verk ot al , ...U. _
\he lQerat017 18 pl"Ogr•••lq ••' l "..'ort~ _4 IIIIr v.ll be flat.h"
_...wi thla 'he .at
or , ••• v.... !h... ~ leell
4.1.,.,.
)( no'u~ pro. . .t ot vb!ow cl'" whloh dtheqh 01'4• •', 18 lUll no'
h. . . .0 tar •• I DOW. W. ar. IUltlaC pl... '0 «e ahM4. pUlac ea.t ••
mob . , po•• l\1. of 'h.
JIll' .. .ooa .. It ant...
'hoaP
the work 1. aot al' ... thlr ea.pl.'.4, •• ,hat tt will b. po •• lbl.
haY.
the tonal 4.Mo.U • ., the lallorat.,. lefor. Dr.
1M••• fer .aea\1on U'ou4 'he tlt'."'Ja. of I",'.bar. I' 1. 4oa.b'tal.anch ,hat v.
will b • •\1.
40 _eh _hal .erol., 01' 'aot ..lol.., bet.. th. _t
of 8ephmber.
'we
."_at
eqdp-.'.
ap.,.
'0
..ft '0
Dr. 8p.'. hal b •• In'rodulq .. '0 th. . . .1_. ettlclal. of the
Public Heal'h lerno . . .4 to 'h. at.,., ot the . . II"cnqt.
yUh ,which ve .hall 110m. OV pr..... hal b.en oa.tU••4 for 'h_. _4
ar.
e1pea. th. _ell ta 'h.tr '.D. Precraa _4 the IurCeoa
Gen.ral of the ArrII baa .... ut.a lf
eM ,., "" • trea,_.t J)l'0II"- la
'he K11U.., Ko..-pl'al.
.
~a'eaal_
•••lIea'.
,..t..
w.
. !h...
'0
18 ~clo •• 4 • COP7 of the pro..... vhich 18
be .tp.a ", the
Mlnht .. of Baal'h, W. ad. aoe'bel'aael,.a. !h. 1'1'1... work e••• a4er the
Jurh41oUoa of 'h. 1.., •••4 4.,. . . .at. , . paJ'po,., ot tutlU.'t. .
0'111' work her. Dr. Ipo.. 'elleY. it .U7 Ilee....., tor
to ulert •••••
'rea_.t procr-I. 1. the . . , holpUal ..4 1. 'h. J)J't ••• ". 1ha11 haY.
acelln' tac111U .. f . 010•• toll.".... .. ITPhlll.. I' 1. "probabl. that
ob.e".U_ 1. 'h.lr T._eal Dl . . . . .0.,,1 tal vill a ' b. .0 elo•• , .0
,hat oar 1Jl)lt.111. tr. . . . ., .., b •• eoodaJ7 '0 I • • c.onhea .n41 •••
It appear.
ehft1a b. able
eYalua' • •
Ql)hlll ••ndl •• uc1ac
,h. be .. ~ _lxtv. a4 Dr. Ipo'o u4 I .ha14 11k. '0 '17 . . . .1 •• lldlSC
11'
'ha' w.
'0
011.
ct."'.
300.000 11 claU., tor .1.,.• ..,. which will
a POO'ap oOllpU'abl. to
that ,i",. 40.000 U _ z • whiell
al.o apeet to 11•• OIl other. her ••
I 10\1 IIpprO"f. will 10a 1'1. . . ora.
tor
'P.U.llh. ,ar' ot
whiah rill b. u ••' t . v_••, .t ceaonhea.
w.
-ouch"
aoo
It 8pp. . . . that it will 'be at l •• t two .oath. b.tor. there rill \1:
ot Dr. Harlow .0 that h. 18 1'ro"*'17 Bob DOr. nlllsbl • •t 8t.t ..
h1and thaD her ••
1l••4
ea.
III ch.Gkiae 'broach ov paakilll 118' it ••
that th.re h 80
. .terial tor &Olel - 1'l'Htlac the leek. 84 'able t~. III the ttrd Ihlpmet. It ill ohectlac ~oach the r.aGl'4 'her. it it found Ilot to haY.
b . . . . .t a01ll.el 1011 pl . . . . . .a4 11. a nttlal .., ~U '" b7 atr a;pr ••••
tor 'b7 rep1ar h.tcht it will , • • OftI' a .oath _4 it cazmot b. leev.4
her ••
w. hOl). too. that the VP....U .. tor 'hl. pZ'o.1.ct rill b. lacl1l484
III the Ilm .h1paft'. for tMr. 1. a
III thl. offia.. UnUl th.ir
arriY&l
I 8hall 11•• . , 1)ol't-'l.. _~. wr ••llle. both r8C'llar
u11, peeel. 'P0.t. _4 b.ip\ , • • 18, !O. aa4 ...e ..,. r • .,eoti",.17 I
1\ .1pt b . . .11 t.r 11\1 eRr......... r ....Uac 'he
to CO atl'
aail _4 tor all 1.,01"_'. aa11 ehl,..,. . . .4... til a han7 to «0 air
_1"'"
'beach.
apr ••• or alJ'
,1'..,."
_1.
Ilaa ...b 1ft1'.,
10. C. Ca.tle
ta:rc.. UIPD
'.1..
lo • .,h 8. 8poto
Chief I CartbbNJl lea' ..
!)ear Dr'. Arnold.
" now we are ".11 ..Ul.d. hannc U'l"IYed the " a l... \.to!'. la.' at doo.t
3&30. Dr. 'lUle, had mad. err_e",enh tor u. '0 go rlcht '0 a 'P8Dl1on vhere tare
$8.00 per 429' we hay. 1"0c. and boar4 In 'h• •o.t luxarlou. ot IlUt'r0ta4lac- In
'h. prlY8'. hOlleot a t8l1111 vhlch va. one. Ye'q vealtb1 'bI1t vhlch It!! nO'lroa' ot
poUUcal fanr. B, \lie v"¥. U 1. the plac. where v. ahalllll e\l. to JIll' lIP the
other. vhUe the,' are looklne tor A ."laoe to lly. and Illio where ve ,hall be
abU
quarter Nfl ..-l.Uors
oa.not . _ wl'h u. I'.1f' In' .... ' 7G1l to knw
that all prl0 •• here haYe aone up condderabl1 .Ino. yt:N:t' n.U htre, .0 ltat
ho,.l ohar••• !lil" per 4., tor 1"0_ alon..
Oar ntcht her. ho. "-ioo OiV v.a
all that )'011 ,ald it vould be. e:dr.el1 'beanU1'lll. aDd. thrUH~. end 7oa. III.., M
are that ve vtre mo.' happ;r to •• e GIaa'.-ala. a cl .... ~ro8p ..... pl..,..
Mexico Oi '"1
8r. Del 'eochlo va. YIr'1 kin4 '0 UI whil. la Malco 0i')' -4 mowed u. all
at'OUDd 4u!'il2« hie spare Ulle. n. lllboratoJ')' there i. a Yer'7 go04 10okiDl: plac.
_d I ••• to _. vell l"D. III talkillC
\h• •'her ))'0.,11 ,~. l ' i. m4ellt
tJaat he i. Tery ".11 llk.4 an4 h 4010« a «004 Jobf h. H • • '0 b. a id.al
choic. t~ i ,.
t 'Iterc1.ll7 Dr. Spoto toak . , '0 1M oar laltarator'7 whioh i, UJa4er 0 cmlba.Ction 7" u.4 vhioh vill aot b. tlnioed tor alJout 3-3 vetk.rl \h... baT. , ... 4tllIQI
cla.. to 41ttiouUy b."roO'1ll'lnpaerlal. o' on. kln4 and Imother. tle last of vhtaJt.
va. 'h• • lall tor vhich Dr. Spoto had '0 ~ '0 M.lco OiV_ . We haY. Ilot 7et
met th. ohief of \hoetr PtBI8 •• tar ht il on yaoaUon ba.hhCMlIt be back In A 4IIr
or tvo, ~.. at'er •• eUne hla he v1l1 tak. ae to I.e the otherl. _, he van' • •e
to ee. ,hechi.t before a.y otherl. W. lav ,he b".a'.';;C'.""%e! Bospital ot
Dr. 'un•• vhich il nov tull to (' RpaH V AIl4 vhioh now con 'ainl abaa 20 uU y.
mal.1 which are being .tu4led ", the onohoeerciu1l 4VmIJ). I vae rea117 lllUoh
llIpr ... e4 b7 it. tf he 11 tl')'inc har4
J'1Ul it al he leeraed ill ,he Stat •••
loth Dr. and
JUl'1 ....d about )'ou· aIl4 Dr. Mahon-r aile! .aked .e to «iT' 7~
th.lr reserc1a sad to t.ll 70111 hov 1I1l0h ~IIJ -Joyed )'OV y1eU h.r••
Dr.
hal 'b.en tdl:iDg a «004 4eal. a'bout oat pro.1.ot lUll thi8iDe abRt
it. •• I~' that with 'he Indian. tn 'h."lloa ve ~ v.ll do Ga.P york v1 th
little or no explanation. aa thl)' are anl7 contule' b7 w:planationl anc!kn ov111C
vbat 11 hap.".alq. Ltkevile OQI' p.,.a' tor th. 1Ial.1 vill lao coaddllr.b17 1 ••1
than v. had aorlglan~ plane4. He 18\11 tha\ we thOOCh \h. ofticiAl, are d1
read7 tor UI vt eha1l haYe to work TfII'1 11GVl1 in «"t1Dc Into the 1)roplv'laoU.e
and lat.etion ,tudl.,. tor he 40el notwant.o ma.. ~v .I.tak•• or t04e &D1thiDC
,. Jeaporc11 •• our work.
In 'bu.lldlua 'he croua' von v. ehall I.' up 'be lab ...
'bec1n to ,lIak. IlU"Ytl;Yl of infection inth. D<7pulaUon ot the 1)ril. 884 ,. CB« 'he
proIUnt ••• an4 to trda 'he na"iT' vorkerl. II. vould. 11k•••J"7 II1lch. "0-. Ule
tirl' ot oar PI'O.18Otl. to tJ7 80.'- treatment ltutii.1 fit COa8!'!'h.a OIl Ul8PaU.'1
vhoa v. 0" keep ;"411' obl.yat!on In the hOln1tal _4 ."rt.... uiDe cna1h1'ai·
l'udl.1 of-cure Jult a.
h a1 411cru.es.4. I' aq vell It. tha' v. oa ~" • 1.,.1'
aouch l'l"otlP. tollov.4 ltlDC -oach to put
1'", t . the lIOon4 Um. the
penlo111ln 11 not co04. II there lUIJ' parUcu:lar eh.c!ule ,).at 7 . vR14 Uk • .
l>aJ'tloullll'17 '0 '17, 'h. &>,000 17 Ilab Z ' . 01' , ..
or· il 'her . . .other,.
ehort .. one 'hat7OU vou14 tik. to tl'J1
.
!hI)' areltec1nnlq to ue ennl14.. able chancroid BIld l.7JIphocramaloma fy_~. .
here ad haYe Ila4 Uttlcul t)' " ••~ Dur., Y&ocilll and the h.i aUc- I. tbA ;
l"al)l& ' ....' . a ' oa'.. Dr'. ~'I IUk.4 It ve 1I1ch' P"Oll' tor h1II '0.1t .\
then \It., voul4 al.o 11k•• it 1)oldble, to hay. UI run 'he cc.pl_.' ti_Uotl
telt tor L.G.' •• I baY. '0.4 'h_ tha' It 11 no' saU8tactOl'7. bat
.Ull lom...,hat Intere.ted in it. It v. vO'llldl1ke
try It tar th_.
. ' :,
!he Ihip. . .' fit lab '4I\1i"..-, 11 at Pa....'o JM"J"1el. bat 'h. . .e 110' cot~
·
to tl')' to hurry U up here. .. tbere 11 nov ao plac. '0 JIll' i" howft'eI' 1n 11.
nOl"Jlel emu-•• ot wah i' Ih~d U"J'ly. herevUhln 'h. n_t v ..k or , _ _ •• '
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1946
Sur,eOll ll.C. Anola. USPHS
l'..-eal MI .... leee8l"oh Labor ..to17
t7.8. ...1•• BoepU&l
Itat.n Illead 4, .'T.
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Dr. £no141
A8 I told 10tt in the 1.. , 1.U.. Dr'. Heller 11 lntereet.tt in hATt
photocrapbic reaord. of th. projeat here. ille .. vill be glad to
do what .... 11 nece ..az'1 tar UI! me hal had aperlace In lUll
pho'OCZ"lIpllJ, _t hal had no ap.nea. wl \h lIOTinc-plcture photograp~, Ih. t ••ll, 'houch, that th. v111 be able to do both tTPe.
vi~ .. little ap.,1.Jaentation ad l\udJ.
Dr. Beller BAid to 1e' h1a taw vhIlt type ot equl'Pllen' ve rill
.u 1e' v. do not know vhether the ~ultemaJ8Il "'bll0 Re&l.th
Sert"lce hail tUI3 lqu1'Dm.nt, 8llt\ U IUIP;)' bft eer.rA]. llO!"e dqe betore
,ttl cakaov.
WOW"" :Ill ell hal lwO\l&ht hM- 4x!5 lnch Tlev Cl"lIlel"a
wi til the e~ll'.eat tor 4"el~iDC filal, ll«ht m.ter, trt'P04, Anti
tlOIDe 1I11c.11aa80111 ~lJ)nulIDt. Sh. hal • luge, 'Prot.uional enlal"«er
In • ." Koeh.lle which the vill b. «1&4 to haTe UI UI. her. it the
I.aboratol'7 oan .hip U here. A8 .oon u ve mow .e IhAll lend
instruotionl tor 'Ploldng it 'tIP it a .....8J7.
She hal 'brought lnlt t." Chaloall vith her, ~o that it the raw
material. oan be .eat UI frOIi the Itate. ahe ca atx tll_ al ne.ded,
lanBC 4l\1Ue a bl'. llLe 40•• no' haY. aJq ot her In''r11O'' ')!1 book.
and torlNlarle. nov, al the,' ar. paeke4 vi th ou hou..eho1d «ooet., bu.t
the croup In WaahiDCton llhould knew
\¥pe. ot cheJllloall tar deTelop.ent and ~rlatl.. a. vell ..I wha' ~e. ot blaCk-and-white
a4 dolored tU. are needed. (1u14_t8117, Mr. Morrl10n C8Zl check
to .ee the IIl.e, t"e, ad aUlllb.. ef oolored tUJI he M'd...4 8Ild«1Te
that lntorm..t~on.)
A.. tar .0Tl~ 'Plotures with ls... film, IIhe v1' 1 nef"6 e8.lllere.,
vlpod, 8I1d vhat .... er othArtrPe of equlpment they deem n8ce.elU7, as
well ... tn... She woa.14 allo llk. 'ohaTe lent laTeral «ood. 'book. oa
-w1Dc plchl'e mld c.... ph.~OCI"apI9.
It routine photographl ot l.don. 82"e d.edrea Ihe 'Would. 11ke
to haY• • aall r.n.a-t7P' . . . . . . e1ther Ba.-.m '1' CJel"IId.. 'fhat
hal the croaad-sla. . 80 that all p1o_e. CBll 'b. leen before 'bein«
t * . aD4. are tlm• •are .at1et"o~ol7 thaa the viev caaera..
all
08881"&. ~eclal .hort-reD«' leal" tor clo • ....up wOl1r ... a.ede4.
Would you plep.• e torward thl. lntO!'1latioa to ~. R.ll .. 10 that.
hl, «rMlO CNi 'begin to aS13emb1e the' ""tanal'
Tour • • incerel~'.
n....
wha'
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111m O. OtiU.
I.A.. IuoC •• USPHI
.
...FEDERAL SECURllY AGENCY
STATEN 15LAND.~EW YORK
OFF'ICE OF DtRECTOR
VENEREAL DISEAS£ RESEARCH LABORATORY
U. S. MAIIINE HOSPITAL
AU8Wlt 28, 1946
Dootor John C. Cutler
Officina San1taria PanAmericana
;;3ector Del Caribe, Apartado No. 383
Guatemala, Guatemala
Dear John:
I am very gla~ that you enjoyed your trip to Mexico City
aDd on to Guatemala. Doctor Mahoney 1s still on leave and will
return to duty after Labor Day. I sent the in.torJnation regard1ng
photograph1c equipment to Doctor Heller. I think it would be rath.er
difficult to Seoure good motion pioture equipment for the project
unless we oan get a transfer of the Cine Kodak Special from the
~rine HOspital in New Orleans.
For the routine photographic work,
would it not be better to use c~ercially prepared developers and
fixers rather thaD attempting to make different types of mixers?
I am sorry the build ine program goea so slowly, but the t
ia to be expected because of the scarcity of materials.
I have no partIcular suggestions to make regarding
sohedule for the greatment of gonorrheal infection. I think
miniMum of 300,000 units of penicillin should be used. That
be more than.adequate therapy for the average Guatamala~who
20 to 30 percent less than our patients here.
a
a
should
weighs
I will try to obtain some chancroid and lymphogranuloma
venereum antigen for you. The complement fixation test for l.g.v.
is useless, unsatisfactory and a waste of time. Mr. Portnoy would
be able to perform the test should it be deSired.
llr. Portnoy left the Laboratory yesterday and probably
will not return. If it is possible to get in touch witb him I
shall Bend the medications which you requ.sted in your letter ot
August 24th; otherwise I shall send them down· in the next shIpment.
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0
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Dr. John C. Cutler - August 28, 1946
Caroline has not returned from Kentucky. I may 80 atter
her this week-end and take a tew additional days leave tor the purpose ot dr1 ving the old car back. New cars are most d1:f':f'1cul t to
obtain and I have decided to keep mine another couple ot years.
Thi~ are going smoothly here at the Laboratory - believe it or
not - but Bob and I surely will be glad w~en everybody returns to
work.
Best regards.
Sincerely,
R~ C. Arnold
Senior Surgeon, USPHS
In Temporary Cherie
RCA:hmr
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U.·.&. :PVPLIC .HEALTH : SERVICE '.. ,
.' S"iA'TENISl.A.... O, NEW YORK .
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, . Cln'ICE
OF DlR£C;TOIJ
,
vumtEAL DIS£ASE 1I£Sr.Mt1t' lAIOItATOW
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What-·a., d1squiet~n~~k".but . !l'le~a it wll~ ·worJc out-: alrilht • .f '!e
a
bit aupriaed at Joe s lette.r. and. '1OJIfl.- o.1' ."tlhe statemen.ta, aod. hial1ilttJOt : ~a.. ~ing.
J -.y be. wrang but: :t ·be'l i.eve :t~. he ·'ftflj:ott:eJ'ed at1:the· l.u, • .~1e ' .b ..e~ pay plua a
.per·.diea.. ¥ou -.re to ~t.' 7 :and. he and walk ..r wen. to get .6. Ttw. 26% 1Jlor~t8~ ~n baae
. . oame 'l ater ... well o..a the 7'. ·.t..t' h har1i .t-o 'C'OIW Gown ·tToa .the ellNpeoted ll1gb but
there' ar. ' otberthinglf~ to ioouaiderw ' l:t prabally will be 'guaged, ~ _tter .orprinciple
n.therthan· as a JI~tter ' oD JaODey. Wh1" :should·& ..bH : ae"·1._ Ulpl~ get ipoO. ~to 2000
aore than the ohief medioal orticer running the ahow? It places a pre}lliqa , 011 t~t
statue • . I do 'not: be.lieu~ he " 8 ..:gil.'9'e,ll .any ... aul'All08 t;~t . th,e : ~nCOJ1l8 taxes would be
· . . i~d, .lI&ybe a bit ' C)t wiahful .thinking.. · and maybe .~ome .hava .gotten by ill the paat
bY .ot ... rtn~.n issue o-r it anu aend1R~' their ,toNa .. ttp the, I3l!ilti,lllOre of't-1oe which
hae. a 'reputatiOD of' being more lenient w·rth trave'lin~' 8OT~r~~t~ople
.a~~· sernoea.
1 would <n.t1ler ·888 J'oe'sta) amf ,taink he' will,· ;~e a ·good . t~ and i :wil.~have a chance
to···do· 'sQ)llt ..1aportant work·. in ,erlabU;.lthln~ the oa-rdi.o ·~e •.t • . ~aR8Q~a~~y a~c. 'the
• a~"le. oa'~ haa been upset .by ,. the· other Dona'P8Qit:1~ reac~.;~o~.. .' )' : . . :'. '., .
. :'.
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I am .just wdride ]~iD"!: .1-1 the ,Dettd is .. .. ; .aa . u.~t. -1'qr:. added oos1;s ••
he- clllilla. .. 'Ia he tJ'Ying t'O·:~ 1UP and ~" OJ,l'tAo .~tbe Jo~..... .R.~. JIluoh ~~. :be' :chan~d
hi.- standard ot- liv-1D~·. Can ··be' up8c1J \0 'spellod ;'7 . ,.n~ he mak••. .7. ;@d ,.till·.ll1a.h to
aave '2 to -3 thoU'aaJid a year. He 'ZIIa-cle ' ~u~ ,,"QQ. . nere.• , Had tJ'..vel exp~ea'. lunchea
away, traTel t-1* "to ,",ork', maybe the .·work _t "home . ~~ a ,:hi.t b8aTi~r or '.'If.ier tar
:.the, .... its' • . Dfd ·He belon~ to· the ·be.t toountry olub _~ •. 0171os~ ,~~ or . ~~·r.e:·,a.1t.:a game
of cn:ce •. (it he' is lu~ he .hollld br~&k about tsV8.n OT;8 r a .lon (·~iod .. pl.y~n,
with the ·.arne peopl_) . 'aDc1:- a lot ot 01lh.r · :rath.~ .•xptp.l-..,.. 1~~ea . . ..I .~. n: ot
" ~rie ; todeny touttlke· "tho. . :ti.hinga o\tt : h he .. ~~i~&. ~ , ;l~v,e ~nhi.. ~o~,,~ sCf.8.le.
or arather'1ixpaJid.cl en. tha;t .Gan'.' lall\ ..~&.tn ' - i ~t,U:p1&' ,,~o t~e, ~a1ta~a. j"~ t.h.;ng the
: ~~b.· h&. betni ' pret'ty ~ood : 1Jo ;:h1m; h.,!.ba~·~t~ ..ciUy. . r~~ t~OIII .. p~ • .f.2• ..~3 , ~d 1;he
next steP .rill betn'ttle cerds ·. to!"> .hU • .. ·B. ~s,. .jq~ ; to . do t.l't,re and itJ.a "not a
question ot"wJiethe~ he ·oan· do .it 'Dlst will ;.he ct.o ii • ..• ybe a . bit ot .~r.tren6bing·.would
be adTh~bler" I'd~te to aee ·bia . klll .~he sooae.t~t ,~ay'~ . a.~01d~n ; !gc-"*6t " s~ much
t~OIII a· dollar ed C)eats ' an~'le but from~;th. r oJport~1 ty ~i~ .. polnt;. ,.~ : p.~be~!d ' fitt was
a6re <'. hen "f . .8 ' ttMfre but I ·tAaDk the BOis ':'ried .to;~ t .. ~ · r . ~Qr
; QQnq~fn~~~ ~ We
'. real1&e that :
ahotiltl ' \)41: git1JtJlg ·.oN.• :but.: th.. ,. wr~,,~g . Pe.-!so:qi:.rais~a .. t.~*a~: : ~d
fixed ~~in,s up fbr &.1'1 'of 't,o u.· ' . I ...,.ju•• '_9...~illl ~. y.ou are ma)n.~g out .
f'r<>m & tinancill . stuupo-illt. ' ~en tAougb ~ JuI,~ ... a op.upl<.: of cbildren. 'your ' tlxpenses
· are "a~ou't' the 'SMte- ' 01' : ma;be you halre .aore .,:. j4Je·. t.. ot1'101al · .nt., .rt,i~i.~g! . A. o0oktall
party is' _ex~ns1ri. Your ea·1' i ... an addecIJ::e.os.~ . ~O(h . I thl¥ y~r: ."tan~rd · ot. living
is "bout the" same as in the atate.. with. tne · u.~l .xpected increase a~ fl.rst. . You
· and. Joe.· had s_tfrlil~ ot a butter. JIK1re so than Alioe . and:~.~~h. Do you. thlDlc he
ne.da saile extra ed' how: much? . I am just.ondering t,01A • . pars ~nal s~tspolnt.
joe .111 hear trO*ll ·Dr. 1.h ,b ef'0!4 you: oan'-anAer, but y~ur th~ll~ht .: ooUl'd ' be used later
on~" '. It loe inSists on collllng ba~. ,. can ;4~ a r.epl8.F~~D,t, 01;' ro'~ .tty ~n. , else
but· that' .ju~t holds' 'bFlCC .p!'ogMts.a tor' a· 'w.hUe. anci :t>eaid~,8 .he: would. )~s.er;.~~ '. , ·transter
baok to the ' states for llvwg ·ha.' not decre.21' . ·U a.t! all. .1nl~c1; ..i t "'l$:a. 1i1crn1led
· by 1'0 to' 207o~ ' A year ot· two 'should naJce. a b~g~r '!:i"t'r~repc"ln' c~~tot · l~v.int· . here
and it he· ...can S'ave ' somethin~ IIOW or 'nell .Q"ak. .e"'~m., her.:wi,\,l ~e .b.8.tter ot . ~ at&ying.
Likewise he will u~·,,; ·:':'he· 6'ppurtuni ty ot coming up wit'h a good pied.. ot work. ' 1'd
hate to see him come back because it would not do haim any good, re~rdleas of what
reason h. would give, 80me would not believe it and he 'Would be suspeoted of a lot ot
thin~s.
People juat do not like those that ~ive up the sponge quickly.
Whiit 18
your opinion?
Hope the
Normal rabbits(N) in eara and 2 sypjilitic (S) arrived
OK. The male. should be OK tor breedin~ purpose~, or you oould use them for strain
purposes. More will .ollow.
I am a bit, intaot mora than a bit. leary ot the experi.''Ilent w1 th
ot
i
yO'
an
-,
:~i~'Jisane
people.
1:he,y'.~n,~not. 'gi~e .o~~~.nt'~':-'~o
not know what is
:; ~p'~4:i.'~
, JJ,~.·'oody organhati-Ml ' ~b't, win\:!· -()f the · .ot~J( It~yL.ou ld raiae a ldt
and if
.o f:.· ..oke.
;- l · ,~ the soldiers would be 'beat ~ol' . the · pr.11!Jj)ners for they can dfi .oiaent.
Mayoe- I'm too conservative.
Alot depends on themedical officer ~d the' reaction of the
supt. of th61ns.. - hasp. Also how many knew what was going on., .. J.. reaU~e tha,x ~ , pt
or a dozen could be infected, develop the disease and be cured be.fore anythin'g' could
be suspected.
l'he penicillin could be a .Hx for the insanity. your first st1.1dy
could be dl)ne in a short ti:ne and n"ne would be the where In the re~. I see no
rea80n to ~"y 'whel'etlM' work was' done taDdthllJ· .t y-peoi': v'olunteer. You know the setup
best. ':but. be aure th*t all an!l';le'8 have been oovered·... · : .
. onebther ~~peri.nt could· be donetoo.,tha· actual! 11:U'eotion or: attempt
to '!nfeot the eye . .·.l·th GC pus 4'rORl '''' .p t ..- or' ·by ,the oultured .orpnisu. lt
be possible thtlt· the eye 18 a rela101vely iJlsenaitive .bod.¥ and do:ee not ,btt;oOllle 'iJl1'ected
easily • . Maybe the Crade method is not nece:uary. 'Ie' 1~ utied there'l ' In hoapita.la
. and by ·the looal midwife-I! - How: Sloh .opthalDlia is-seen et ry~' '. Just a thou,cr,bt tor
.' the tutul"e.
.,
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At a me~ti·ng in Wash~' yea,t erday,tbe --:nlY and .Ha.'9Y' people wanta4to
knOW more about t~Pro.' Both want .to: use· 1-4:' but we are. holcLing 'baok -\Ulti). . , "at
lIIore data on' 00. I feel pYetty· 8ure of' the lIyphHb .proteatlon fro. the ao-1.,.l
study. 'T)1e t!'eatmelit of ' iyphilile wa~ diacuS8e'd and it 'Jfas aore soore as u.ual ...
That heavy' metal dOe~iI no gaod I~ 11 aOdept · but can' t beiieTe· that the·. total dOH
-r::laya no "part 1e .Il to 4 ',8· a1111'on are equally !~d, the. _tbod .of adn181strat1on
does not matter, aqUeouaor POIJ. That the ·time between do ... doee not ...·tte~.ie , 2.
:3.4~
·e··hours between 'doaeagne the .ame ro8ulte. ' I'll 'go !for the idea that
aimilar responiell will be ' obtdriedwith: good tr.~Jlt in :4. 7 .S; or ,14 :~8 • .
It 'is not neoessary' to treat J'fltieatsfor' 10D1:8r than one .week. me.ybe ,not . ~.r. ,than
. 3 ,or 4 days. I cliJi It bel1..vethat ~()dpenio1ll1n therapy wil·l ,produce 26 to ·30%
f'-~lures ·.
It Wfl'l'l;a1ce another year 'lor theerror. ~ becoroe evi,d~Dt f~om .. " ;
s~tist1eal poitlt. " Hell, ,~ve _ .. good olinicial and 'one ,.111 -.l-e~ JIlqr88y~pllle
in a1.a~tha't: 8: ~dted ~~'r't, ••OkeyM. ·th. . . .at 18 ~.Qt&ble.(:- . - >. . ,.~t1aticlana.
"hen a .pa:t1ent atu.r be1nt'_~t1. . 'tor · 8 lionths ·happen. to ;Mve • po.~t1.ve ,
blood test frc;'.a oold,' 'is ''then ol«asif1ed jaa a t.Uur... thea 1"81 aour OIL the ,whole
numerical "1!ushittia. wheil It patient · is '·set'oncg. tn all diagaoatio ,w~ta . : ~clud~ng
the :ii~~d ~test us-ed for ' qua'ti~iation, 'lind .1;hen the- qantitatiYo teat is poa1~~y..e in
16 un~ts(Dil. :, ot 1";") ttlepatit?Dt · is olassitied as ,a .• eroNl.,s., I ~1nk .o-.ething
Ulel1a • . ~a.n ''l'hOll8.a · repo·!"ted 'results ju.t ' Uke our -iOX86. lie . ule.d ., 2.4 OIl ~2 , and3
hou r ache d1:lle. '~ houra t tn' 8.8% r ..Uure whUe ;the .2 hour· p ve 2 ~ 2%, , The~ he had
4.6 on'the lI . .e·roQtine ' ~ houras,('tallurea ;d 2' hour• .waa 1.9 " • . • 6·Dli~. ,u. "
gave 3o~ , fallure ' and ' 2~4 gaTelO% atttr': l and 2 yean • . .lnd 14h•• ttlo,-.ay ~t the
total :. .ountand · t1Jie ·interlll.lat' at'e not ~ imPOlrtut rf.Oto", • . Thoma . .... s , . l!}. ~ as
a wet hen. AlIO ' Sohooh 0" !ens, and . 8~e of the other wor)terl : (I~ifer) .. .. , . .... .
. '
' . t ·t.tiip..k the 40X85 rep6rt will be ready 10011.. T~e Bo,~ saj.~ it .~.o,:,ld be
ir. print riCht away before all this 'crap <>ome. out·. Tha~ 11 ~ accelera;te~. a~tem8nt
from~. Usually Ile d~1I not ruah UlUa,;a. · -How. 1e: 1.e~1!;h n;a!tip~ out? Work1n~?
and" about the Malaria? '. Bett'~r keep thi8 UDder . the. hat for 1 ... LSkiq f'o~ . ~our
OQ . opin~on of thu whys and ·w hereforell.1'01II!IIJ and Xra Sn.ntOJl-ba.ve a,. baby. ('goll)
bornto~y. Thetreenhouae ·~s opened today- . Theamall pox, .~are ,i s caus lng. a lot of
people to. b~ v .. c.~illllted, when the .accine i. avaHabie,. ~rj~e Cookie ~o.in.ga good
job on follow l1.P", ~ttil2g back tome of the oltter T'&ti.nt~.Had: ." :le~¥rfrOlA IS
l ....t week •.Te·lIt: .1nCle'Yel8.nd X.Hasp • . W111 And 'into""'tion of .the next ta:keot:f
when 'tne pap.,t 'is teady "or approvlll. The 3 day Rx lo*a pretty go.od 80 tar •.. We
, , aretraatin,g .a:l~ . i ~ that schedule no~ • . It Usell ' aoft' JIlItniqill1n b.u~ we are fUrnhhing
. the. dru~ • . }I~per is ~hort. hour is ll(te, more later.' ," ._ prda to all.
.
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.6,5 e..e.r.
may:
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STATEN ISLAND,lNEW YORK
OFfICE Of' DlRrCTOII
VIIlEIlEAL DlSIASE RESEAIIC;H LABORATORY
U. S. NAlllIIE HOSfITAL
February 19, 1948
Dr. John C. Cutler
Sanidad Publica
9a Ave. Sur y - 15 Calle Oriente
Dear Jo:.·n:
Doctor Levitan departed for points west and south early
this JII.orn:ing. ~ve were all more than glad to see him and to learn
at first hand the progress, of work in Guatemala. Needless to say
that we were all impressed.
In going over the work it appears that most of the good
tricks have been taken. ~~e were all mre than gratified over the
prophylaxis results • . Although th~ findings in gonorrhea are significant, even in the face of an overwhelming exposure, the results
in syphilis are most informative. The outcome will give added assurance to the field trials :in Germany l'which should get under way
momentarily.
No doubt you have learned of the change which has taken
place in the Surgeon General's office and, less recently, in the
office of the Administrator of the Federal Security Agency. To
date we have not received any flashes as to the policies which are
to come. Equally uncertain are the changes which my follow the
installation of the new group at Headquarters. We do know that we
have lost a very good friend and that it appears to be advisable
to set our ducks in line. In this regard we feel that the Guatemila project should be brought to the innocuous stage as rapidlY
as possible.
I'le are in serious doubt as to the actual value of Portnoy to the project and su~est that you send us the earliest date
after which his activities may be transferred elsewhere. ~""e will
initiate orders for his return to the States' at that tine. The
entire matter \'las discussed with Levitan and he will relay the
details to you.
I am scheduled to be Q1 the l':exican border ~1arch 20th to
the ;22nd for the reeting of t he Border Public Health Association.
If you feel that it "'lOulct be of any assistance to you, I can con-
- 2 -
February 19, 1948
Dr. John C. Cutler
tinue on to Guatemala City I or if you should need a change of
scenery, we can initiate orders for you to come to Laredo. This
would allow us several days to discuss any subjects which may be
of interest. I \'Jish you would cable me your thoughts :in this
matter.
s~relyl
J'• •
~ey
l';e, ical D:lrector
USl-'HS
JFN:tcf
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Septemb.r 00.
19.,
lou .,. J1ah0ll." M.410al D1rector
])1rector, ,. n. It.a.U'oh J.a'bora'OI7
0. I. Kar1n. Koep1 tal
Stat .. Ialand 4. Wev York
n.ar
Dr. Mahon.-.
I t ••l t0ll1ch' juat .. I t.1t "he the newa eM. ot the dM1d. to 41aaoat1llv..
the ' ..re Baut. project. al thoaeh the blew h harder now than th.a. tor we ha? .0
_ah aor. at atak_ 8Il4 we baft h1chlY n.c~."1 .... md.ece to aIIk. u. b.ll..... __ t we
... On the r1«h~ tract wUh I".epect to propqluh. 'lor aa 101U' 1ett81" Ott Sep'.bel'
I lei aUo1p.te4, we ahall, un1ees an.....nt. 0_ b. aa4•• 'b. ~.4. wUh the 41 ••o1uUon of our .taff "hlah. under the oueaanuo •• la JueUtie4.
fbi. m\)rnlng at 7 A.M., Jult attel" 1 had rewn.d trOll ae.ine our ne:d .-.n'tl..
an47 1I"<nIp . , the Baee Milt tar ent frOID 48pos1 tint; 'he l .. t r4lJ)0rt to 'au ill the
AJIO, tor .eoar1 t7 r_eons, 1 saw ...rt \h luba allot the 130 'PaUent. on "boIl " . . . .
dolne 81PhUh
t'h1. Woe an g01 tine nperleac., all of tht: wOll_ laocv.lat.4
_ InllUpl. pr ...v. (a&1.1pos teohal• • ) ad r.cetnJtC pI'~lat • •hoved. no m4.u.
ot 11lt.etioJL 111 contra.t
contro1a all at v~ ahowed p."etoal md_c. of , •••
1I0et at tbe ulee who ha4 ha4 a 2z2 _ ..,.ticlal _. . .10n of the pal. aa4 1Ipp11ca\lon ot .a,..1&1 shoved pllpul. toraattOl1 01' uloer.UOIl (.t111 Darkt1814 ucaU?)
wu. tho •• a1a11arl¥ expo.e4 _d gi.... prOpJvlu:h Bhow.' no'hlq. We lei' ~ _ _,
...-AIIa.bled with the group t.e1111& ex1_at.d as thouch ". alght ka•• the metho4 of
preot.: '.A.D.t then the etaU ude pial to repeat the 1II.thod oa hA4q alcmg with
....ra1 other tec!micu•• , tMlln, as 'houch we had.
ot ncc ....
.tudt...
'0
hop..
'0
A littl. later we Oc.p1_\H arraa«aah
' . e the 11l0C1ll.ate4 pl"l., the t11""
at wca hae bepn to ,. hoy ... 010«10 m4eo. at qphl11., to bttcln .nU.. OIl ,r_aildon na noraal rO"l1te. We t.u .. tboach a' la., we .... pUi-. .. rrwher••
ru.
_.\h hop...
atten.OOll ". r ...1.... , __ l.t'er and _ ddlar note trOll Dr. Beller
..u'
!be ~al. ot all of 'h. .emae. her. laaa .Mea
? ' q low tfW the la.t
OIl aoaOUllt at the cute in 11nJa« allowac .. , ba.t ......~ th.
nw. fd cut. for 1Ir. Pormo, at It .. Walk_ the aoral. at our Cl'0Dp hit bot'.. ht
all t ••l 'b. n •• d. of •• elA« , ___ what 1Iaa be. atar'.4. It". ca.1t all aft work
.. at no'Jt Dr. %.wU. &4 1Ir. PortnOJ' _4 18. . . Wali.r viI1 "., 1ft!' .are _OJlth. '0
.-aollplete the work that 1, now a4.. wr. Jut l' p?.. u. &1.1,;&10DC vi'h OU' Ue- oour. . . . .t at th. aal ..tUla 1••• we . . ntter -?V7 ..,,, t.31bc ,. Mills. t_t
D. I. OW. . . . ., ba. ao r • .,ondbl1tt, what;?oe?ft' vi'h r.8p.at '0 .., o~taeat • .
11&4. \a 1t. ova peraoamel. 01', •• ve haY......._ wUh r • .,8Ot '0 0_1ta..,. nth
for.111l Iot-ermaea.t.. Yea. ad Dr. I.ller _4 ,he ather. haY. 4011. all In ,~ pOWI"' t.
I
peoplo _4 \0 ......,. . ., ,......
bD.\ ,be 1... So tho 1av 0&4 aIoIa&tII
"- '''" '\
nl •• trOll 4a3' \0 4., a4 has no r.apect tflr th. eftort 01" prom •• td tho •• a.,., •• It . . .ea' ••
wie pr.U, auh 111.. , ...
,be
J:::' ,. . .
pr--.
./
'hi.
You haYe lww.. tecl In
pr03.o' 7ear. ot vo1"k _4 r ..eeM tro. 7eaJ'.elt
and 7f1ar daft, ad betore we haTe tlalDed, lIore thaa $150,000 wlll haTe been
Ip_t '0 wlD« u,
the poin'
whloh .e aow tla4 _Ielye.. ~e pola' a' whioh
we 'hlDk that we Ihall be able '0 be&1n '0 uke rNl. oon'rlba.Uo.. _d aoy,
beoau.e ot the 4eol11oa ot am who haY. DO r.al kaowl.qe 01' _4.r.'aa41-. 0" oondltion. 01' work here w. Ihall be toroed to .top top lack fit p ...ozmel. I ehall
.ta" tor "Ut. ,he $100 AdUUoaal PtO' aad ,he praoUon (It lt 1. lIpl>roY.4) .,.
.al327 v1ll b. . . .enUal17 unclwaced. and I haYe DO tam117 coaoerned. Dr. LeY1 ' OUUlot attord to \it.,loq
thoach th.e 1. nothlnc 1. the world that h. YCnllI
rather 40, tor it 11 tlnancial]; lmp"a1bl.. M1". Por'nG7 owot aftord
k.ep
hl. t.11.7 hera ~ longer than 'he tov .onth. n.c...C7 to OOllpl.te nv qphl111 Al
··'u41 .. Ulld.rva;r.
,
'0
a'
eT_
'0
."
)'Ga. aUllat. it Yill b. dlftioult to •• ove replace.eat. Wi'h the 00.,
ot .o~ a4 ce"1nc •• ttl.d h.r., and vl~ ,he rl11DC oo.t. ot 11Y1ac 1 ooal4
elther, In gooA t&1~, reoOllm'" '0 azq offloer or clT1l IWT1ce ~l07.e
M
.1ch'
w_
ao'.
'
0
0.'.
",a. 'bu.' it vou14 oo.t hlm eonlt6.erall17 .orlt, thall the
A I1ql. au
oo.t f¥t quarter, anA 1I0aJ'1l 1. a .etn. B08pUal. A UI'1'ieA . . vUh eMU.!'. wall
" toolhh '0 1.aYe th. 'tate. '0 0 • • h.r. 8d8l' ,he •• ~"'oe.. Ml1e fro.
,he eOllllleratioD vi th re'l'ect '0 \he tlnanelal upeot. Ui7 one COMing \IOU.l1 retulJ'e a p.rlod of three to tour aODth. to le8nl enOUl;h Itpanleh to be of ll\1\ch help
1I.41oal~ • B.lla" that I doubt': Yer, !tUM thtt, the '8"toe has m~ lie. of the
callbr. of our sroap who ccmld be sent here. An4 to tAke adJ-te.ge ot oar oppft'ftal U.. we should have o~ men ot that t1])e who are wzollppec1 l'lp tn the probl_ aa4
who are v11l1ll4 to work . . oa.r orew here BOW. trOll 15100 A.M. on throuch llial",'
11 Deeded•• eYen ~. p()r w.ek. fw "eE«s GIl. end.
'0 'ak.
We 11.. . . . .clentinc OpporWDt Ue. wMah ,,_. on17 rarel1. but In or4eJ'
,,'!IIftt. we need competEJit. p.epl". _4 compe~e~t people. aleo haYe to p~ the ••• t.
ot 11Y1~ l"sqa,1re4 her., a4 oannot do the best work. 1t thq are tUlder tlnanola1
41tttaulUe.. IS 1. tru•• as the oocmltt .... !,TobA.b~ th.o'qht, tbl.".t the
ot 11.1Ac In the "A'e. 1. riling. but. t.h. eoet of llT1Jl« here when we c.... YU a' l.ut.
the .qual ot what 1. now II In the Itat..e. and the rile lD cOlt.e t~l. ret1eo,.4
here, 11 aot upltl.4. At.u Melnl. . we cha4 the MYaatag' ot HiDe able '0 ~,
____ I too(\ for our croup hOIl the ArJ113 Qoma1a&r7, but that. opportuntQ' 1. now aOllal"'" ucept. tar aD oecal1lUl purchM. ot $2 01' fa. ,..
~_ 'he I.raI p",ODU1
-here, who also had cu.ts, MYe no' been able to Ie, coamie&r7 tup,:>11 .. In _oat.
t.o help, 10 that 'he _lilteelllea are DOW haria« to _eGA h• • 'he
I' 1.
lIIpo .. lbl. her. tar _erlo ..._ '0 liYe .. aiUle ola•• Merlc • • a' ho... tol' '~e
.. e DeUh8r .tWe clul nar aiW. 01 ... tuU1U •• Mr• •qa.lyale.t to \bete ........"
whioh we ar . . .ftd • • I. It. abo1al.4 'be =4eI'.t_4 ,hat. nOlle ot u. bu dpttloat.17
ohue" lta4aJ'd. ar 11048 of ltYlq •
~
co.,
vi".'.
co."
.. I poin'e4 out. ni.e _4 I call " ' " lnlt to 11lu.trate t.h.
her. I ahall It..l.e 'h. eo.'~'. keep . , ~•••
r~re'Ml'at.1Y.
lea, - tva.OO, .tOYe wool $20.00, n.otJ'lo 'b1ll $10.00, 1 ••!'Y_'.&.OO
(ml ... 40e. he ow ooaldq _I wuhlDC1, 11Ir481W' $10.00, croe." 'b11l $20 ..
PO.oo (v1t~' lnclu41q oo.t et .., 11ca.uourl &Ad lD a441Uoa to the .tore ef
...., tool 'boach' ...11_ vhioh OUDOt 'b. replaoM), ..., $151 lpahh 1...... tl,2,
PX $15, cb7 clNlllac flO, (1.&0 top a 41" ••• or ru') 1 .11k $5; . .ke' hO (frnh
Y-Ce'alIl •• ) PIIP81" $11 CU'b... 001180'01' $ 2.eo)
-3-
up.""
!h••• are tlxec1
ill a4d1UOIl 'hue are the ohar,.. such aa $88 p~
7ear tor auto 11l1'llJ'uo" $68 tar .arthquak. til" _d th.t' sad vhateM'er v. order
tor the eetev 01 \he houehold. Olo'hiac, ot aour •• il no' 1Il01ud.4, in Ipi te
of the rapid 4eteriol'a\1cm tl'. laudz1l and aUdev.
the Porb01'1 Pili a little le ... rent, bu.t pq almo.t $100
.01"
tor tood, aor.
tor 881'Tanh. $20.00 pel' aon,h tor ftlUon tor 1al'J7, .ta. lo. ''b.longlJ '0 no olub.
DOW snd hAl cut out all reol'eational expenl. 8Ild Itill r.quire. a a1nt.a. ot $400.00
r!.r.~h'
here "",., to li". in addition to h1. 001" tor illl'llJ'8!lce, eta. It le.1 ,.
be thet thaacht 1n "aah1~on that lerYanh and nic. hoa •• are luxur1 .. , but the
hOIliel oannot be l"'U!l "i thout a' le•• t all• •erTan', and Ilone of UI 11 v111iac ,. li".
iu • cheap house hlr., tor "en om' owa tval hr. "nld Ilot Ii', &M. thlll are aOllpl.'4
1:7 united tor AIImo .. Itan4ar4s of lin.c. lor thil
0. . udmolts4 va., ,_
gl'OI1p C8n!1ot A.ttord to Ita.)', tor tMI. tiSV.I ci"'al.' id.a at COl' ••
,ft
.After thil "rq tl"aDk UDbur4eD1ng ot ., thout'.,ht I Ihould 11k. to pflDpo •• leY.raj
poedbl1iU •• tor I.tting AJ'OUIld the pro'bl.. It W3.B 111 'Wlderitancllll& ~t 111'. 1'01"n07 and K181 Walker ",.re gt"eu le.". td ab ••llo, fJot'll OiT11 Servic. and are 1l0" ..,101.
of I'M _erica San1 '3Z'1 Jare.. _ lIl'enaUoul hoe! th agenq not lub., .., to !"U'I
at 11. I. Oo'f'ernmen'. It wae turtheJ' 111 underlt~d1Dg that federal fundi c1"en ..
Il"-'I 1D. aid haT' no strl~. e.ttflt:hel\ eO thAt the Pan jzlJ.efleF.aA S8l11t~;::·y ~'lr.au. 0_
Pair what~et" 1 t iee!tl8 p~oper i h :JYD elftployp-ee. J~r t~ reaeone t Cat1!lot aee wbJ
Mr. Por\IlO1 ant\ Min Volker !]hartld come unde1." tlle juried1ctillll ttl 911 execuU". order
cra.tting lh'lng .a llovlUlcel. The t!lBU tute of Inter-.AIIeriean Aftaire hae ha4 no neb
cra.' in liv1UC allowance. It that ahoultl be the caee wh~ eO'llld not the oo-s..l1oa.,
ottiaer. be il"en leave ot IIlbleft.Ce wi thou' p~ ' In.'' be pu' Oil the Pan. J.IleJ"iaa 8aa1\811
Jare. . pqrell at a lalal"1 and liTt..ng all~aaoel eCfU.iT8len' to what wal oriclul17
cett1D&? I \ waR rq UIlt\vetendint: that 10'11 ha4 been tolc! tha.\ , aB!lignm.nt 0'1 faadl
I'an .AIIerlONl San1 tary ltureBU :'/)U ~<mld bcve Jurladlct.ion OTer aDd fre84011 ot UI'
ot tundl not allowed by tederal 8ocoan~1Dg practice. and that per.ounel OR leaT. to
'1lA AlIericAIl San1 t8l7 :Bureau would be hMaled by Pan AI'Oeriean Sani te,rJ Bur . . _ , 110'
aceor4ia&
Olnl 8e:1",,1ce nlinc lIinl" the)' yltl'e no lODge!" C1Tll .emee. 'or tba'
r.uoD. I sa om.eh pUf'ded at the turn ot n'ents.
'0
'0
I tincerel1 hope that you will be able to tind a 'L~ to k.ep the croup tOC.ther,
1& OR the track ut treaenc1oul17 1I8por'ftIl' tudam.ntal. 1atora.tion, and if we ha.T ' to 'break in a oOllpl.te Ileli stat! we .hall tind CNJ',el"••
0IllJ a It'tle '8i' ad:,.-allaed 1n knovle.sae 'bqcmd that poin.t
vhieh the, aa11 It. toar
aonthl fro. nov vhen the .tuti•• BOW uacieI'WIIF haTe be. oa.ple'.4.
tor I think that the lDliL
&,
lilloer.17,
lou O. Outl ..
hr•• on, tJSPHI
Dear Dr. Mab one,. ,
Within the nexttew daYI we hope to have the prophylaotic atudy in
Inhilis tmder way a8 originally planned. It all dependa upon how Sloon the
throe carrier! inoculated in the o8rTix with human material bag1n to ahow
evidence or inteotien. All men exposed will reoeive prophylaxia, halt ot pl
plaoebo injected and halt ot local applioation ot our preparation. It will,
though, be quite Bome time betore thil aspeot ~f.the work beging to give
anlwera.
We do not have data yet trom expolure to intact mucous membrane tor
2 houri in Iyphilic, but it 1. now evident that the 111oholll material was
not infectious in a ~ne-hour expolure to the intact muoous membrane.
EXperimentl have been done ulir.S both animal paseage and fre.h human
material tor two-hour expo au •• to the intaot membrane. It may be that
muoin "'ill pror:1ote inva 9~." on through the intaot membra.ne. and weare planning
to study that aspect ln the very near 1Utur.. At the samt' time we reel
that perhaps the ~egm~ may aid in invaalan, and are thus plannins for
the next expolure wlth:n;t oleaning the penll.
We know nothing of lnteotlon following ecarlf!cation, but lt i.
my own teeling that w e bave underestimated the importanoe ot minute
break. ln the oontlnulty of the mucous membrane in the invael~n of the
IIplrcchete. FOr 1n lnopeeting the penls in the groups of men in the
gonorrhea studles imrr:edlo.tely after cc ntact we have be en imprel!lsed by the.
fa.ct t.hat all Elhow l'eddenlng ot the glans and foreskln whlch Slgge.t.
both influenoe of engorgement and trauma leading to re.loval of superfloial
epithellal layers and to mlnut.e break. or laceratlcnE 1n the mUCOU8 membrane
Wlth respect to the etf<!ct of break. in oontlnu1tyof tr..e eplthel11.Dl,
the 1'~,.ult. 0 f eXper1!nent 115 performed Augu at 24 for wh~ch you havs the
protocole may prove highly lnteresting. Observations made this morning
lndlcate t bat every patient ln the control group &hOWl a red. indura.ted,
811iny papule meaDuirlng approximately 8 x 6 mm and appearlng ecpal to
tholle fallowing lntr9.cutaneou. lnJection. None of the p3.tlents treated
wlth prophylaxls one or two hour. a1"ter the .1milar exposure hal shown
any eVldence of lnfection as yet. Of cours., the final analysls will
have to be deterred for another three month., but this method, if lt
prove I ucce. sfu 1, wlll glve a. .ean£ at subjectlng the prcphyla.x1 ito
a. much more I!I evera teft tr..an we can imaglng cccurring under normal
conditlon ••
By now you should have the report from M.r. t ':,rtnoy on the work in
.eroleS7 to date with s.ome hlgh~ lntere.t1ns f1:lld1nga. Wh1le our Itudy
on the ohildren at Fuerto san Joee 1 B not oOtnnlete it 1& very evident
to u. that thecardlo1ipln telt i. mucb more nearl1 &peclfio t han the
Kahn or Kazzini techniquel. None ot the chlldren I!!howmg 9.%11 degree ot
.erologia reactlon has Iho",n pro gr•• IIi on characterl1tltc of early ayphilil.
The only one I!Ihowing evldence nf congenltal e yphl11II on physlcal examlnation i. the boy with a POB itlve cardiolipin telt. and none of the children
has shown evi6enoe ot early syli1il1.. What 1. the caUBe 0 t the reactlon
in the other teohnlque. "e cannot .ay. mether it be malar1a. in te.tlnal
para.lte., liver disease, malnutritlon. vitamln detlciency, or "l'Bt.
se ptember 18, 191q
Dear Dr. AAab on ey ;
With respect to tbe Army plan to study prophylaxl. under t lald
conditlon. we a re of the oplnlon that t he test II ho 'ld be mde. W. have
2!s 1et no evldence or t~v altJe 1n syphilie, 'but as lndlc3ted ln the
other letter sug ;~eet'con8 of its value have be~n to appear. But the work
on gonorrhea as md1o!lted inthe complete report just IUbmltted lncUoatee
awry real protectlon obtained under tb3 condltlc':1B prevall1ng. The
low lncldence of 1nteation following natural expo.ure indlcate. that
the test to which the method was wbmitted ls much lItore drastl0 than
that acou rrlng under c ondltLms 0 r n ;.;rmal eJt!')o Bura. A study 1 s alread.,.
under way to determir.e the efflcaoy when the prophylaotlc 113 ee1t admlnistered at 1 hour after exposure. In dlacu.slz:s 1fl th the group the POBI!lbllltles of seouring a larger aerles we ~lave declded upan two p :::,slIlbll1tle.
The flrat WQ.;ld entail using pus to m ooulate our exper1men tal group.
lmmedl3.tely after oontact wl th olean prostltutes. TIle second would
requlre our giving si:lll1a.r exposure to t39 men re!JCrtmg for prophylaxis
tollowing llberty. In that way we oould work 1V lth groupe of ten or
tltteen c . :mtr'Sls and an equal nUllbe1' ot treated patients eVfrY evening.
Ot course we i:ihol.ld. rot hJ.ve establlshed freedom fron lnfectlcn either in
the axpo8ure or prlor to ex -.o llure,b ut the El1za or t ::e c:21trolaTJi treated
group. wou ld be great enough to mlnimlze aucherrors.
We think tlBt we ha.ve solved the problem of securmg ample aupp11e.
of pUll as needed, :f) r we 300U ld be able to ue8 our pat1 entil in the ho B1=-1 tal
under treatment for eyphll1s, lnfeothlg them ar~iflo1ally. But betore we
.at up the plan we ehall !Bve tOBeCllre Dr. Tejeda's approval. It hlnk,
though, t.hat he wlll auee. Und.er such m> ndit~ :):')5 wl tliin a rew weeke we
co ' ld have a e;ro; .tp of eevci"al hundred patients, contorl and treated.
The physician with whom we work at the Guardla de Honor has Bugge.ted
thatwe give the method a fleld trial in h1e unit. There are 1000 men
living 1n a tort w1th only one entrance; about 150 per day have l1ber1i1
between 2 and 8 p~~, and all Bre rDW raq 1red to take the sta.ndard arlDY
prophylazifl when they return. We do not have f1gures for the expected
rat-e ot 'nteetlon, but I have eeen there ail many ae. ten c aees per week.
We teel tl1lt thB tleld trlal thatyo14 propoae for Italy is hjghly
de.lrab1e and J) cee6ary and mOD ld be e arr1a.d on under the euperv1e1on et
the laboratory. I think that Dr. Arnold 1s the one who aoou ld underta.ke
the eupervislJn, first becau.e or the tremendous aIIIount of \,:ork ttat
he has do~ e en the proparat ioo and s 8aond beoau se I do not think that it
wO·.11d be wise fO.r me to :e ave here unt 11 we have c,mplete1y f lnished.
Sin oere~,
(
------.-
.
- _ ._ - - ..
.
September 16,
19~7
Dear R 9.
.
We re anx1oU8 to Liar abv ut your trip t.o lIre.land and w hat. lOU found,
I hope that it was interesting. I'm glad that Ji ~ are haVl ng a Ol-.ance to
t.ravel lnthat way and hope that you will be able to go to Europe tG supervile
the field trial ot the pro. I teel that you · are the ooe to do It, tor it 11
your ba.by, and yo lI110uld MV '- the opportunlty. By now you ShOl,ld have .. een
the toraalreport the. t IBent up on the GO work to da,e, and 1 t looks good tc
u. here under the c oodi ti ·me ot the experiment.. It has been .~Iven 'l muoh
ore aevere teat. eo it seems to me, than it. would get. normall,. but to tlt
the oircum.tanoes m::>r IUJarly to the usual model we have begun now to wa.1 t
cne hour a tte · a :~ pl c qt10n and to let ta, patient apply it. We mall do auct.
more work 6n It and ahall oontInue the normal Ixp08ure. we're gett ng anothe:l
group ready for next wee~, the flret norma 1 expo.ures inao . e time. We telt
that we l'lOU ld ",ai t, for trsre tad been· a gOO:1 dea 1 of talk among theot!loers
1n the Guardia de Honor where we 11 ere working. But. now .e shall work tor a
whIle in another 1nltallat~ on. . The letter to Dr. Mahoney was writ.ten becaus,',
Sacha said that Dr. a. ~anted it to uee in keeping other workers out of are,
but the fear ot too mucr.t alk is conata:itly with U8. and evel' .0 otten we
~ear remarke from people, such as some of the Ameri~an A~y here, who llbould
know nothing of it. ~t we oan't atoid some talk, tor the American ~11itar,y
mission i. working here with too tuatemalanl, s,& they <Ere worki"J3 "ith all
other Le.t1n-Amer ic:m gr::: upe, so tl1i t s orne t :J.lk must get a round.
We are toying witt the Idea 0 f using normal females tor some ot the
contaot. and then 1noculat1.:g tQelll afterward. 80 sa to pile up a aizable grou~)
ot treated and control patIents. And, it Dr. Tejeda approves, we oould go
to the Guardia am treat a portlon ot the 100 odd men reoelvlng pro nightly w:~t
inoe ula tin then prophylaxil turther to inorease oor numbers. ThIIi "o~ld 1nv o::"v
keeping a relorvoir of Inteot ~n, but We th1nk that that could be ar·ranged at
the Military lios:)lts.l. That 19111 ave towsit tor a whlle, rut it 1s in our
a;lnds and wlll be pushed it at a IlfeaaablA.
Dr. salva.&> will b e aw~ for about 6 .eeks, eo t hat we ghallbe able to
no no aignifioant loc~l studiee during that t1 •• , but we want to try lOme t.hrDE
hour applicati :)ns 1n muo1n and to the uncl.aD penis before he leave. 1t it
C:lD b e arranged.
711111e he 1. away we Ihall la.ve thenormal expoaure going on.
tor themechanlcs or that are arranged exoept for startlng, aa we are walting
tor the girl. to show a few ~~ slone betore &tartlng them lnto actual work.
Perhap. we .hall be 8.ble to do t h.3.t late this w ek, for I h':l.ve a d~te to
examine them tanorro". We are begi:-,nlng to h:"ive aome hope for the appl cat10l:
following .caritaction of the pen1le menmbrane, tor on Froday eeveral of the
patient. showed .1gns of amall papulell at the alte w!'!ioh may be lignifloant.
But we er..all h"ve to wait another week, 80 do not get hopeful. We teel that
there il probably a good 41al ot penile trauma during int.roour.e with breaks
in the membrane, tor our observa t' :n 8 on the group. of men following the GO
work have ShOWD for the moet part reddened and battered-looking pene • • ugge.t~l'f
ot trauma and dic~oli.1t1on j f continuity of the membrane. We have begun . ( 8
studle. using applicat on ot dye tollowing exposure but are thus far working ::>11
with tluoroloene and would ~ preciate your euggelt10Y1e and lIending of any dJl&2
you think IIhould be used, for they are hard to get, of.en non-obtainable here.
2
butwe a re all vary Bure that the reactiona are not due to ayphil1a.
We apent the- :a at weak end 1n Puerto e&n Joee ani Ihall aend yau a more
detailed analyail as aoon ae the report. are ready.
In the f1rst g roup at the pen itentlary lnocu lated "i th the N1cb
atrain all of those w Ith negative oardlol1pin and a positive and/or
doubtful Kahn '~JXi ~zzlne (up to 32 Kahn units) were e1tected. and ~1x of
the leTen in the group developed legondary iyphllis. ru t there wal not
one 'ypical ohancre formed. Of the twelvewith pOlitive cardiolipin,
XsJm and Uazzinl only three 8 howed aerologic av ldenoe of inteotion
as eVidenced by significant increase in titre, and all ~f the three
had three or lellB Kahn unitl al the ini ti 801 ti tree If we accept the
hypothesis t ha. t a. !.)rev1ouB,untrea. ted 1nfeotlon with syph111 a cDnterrl
aome degree of 1mmunlty to re or auperinfeotlon then the fact that the
group in wh~ch the cardiolipin re:lction was negative showed n0 reel stano e
to infeotl::-·n; wh~le the group with pOlitive cardlolipln showed signifioant
resistanoe euggeEte t hat the cardiollpin reaction Is much more nearly
spec1fic tcs.n the others. We a.re thuB leouring proof ot the significance
ot the oardiollpln re n ctl cn h1 an immunologic ruan ner.
Wl th the opportunity offered here to Itudy li!yphl11G f'ran the
Itandppint of pure Bclence JUl!t a B Ohesney • tud1ea. 1 t in the rabblt
lt should be poasl ble tu ,ullti ry the p I1C ject 1 nthe event Qf ·th e imr.:)s 9i b1lltt of' reeolutlun of the pl'ophylactlo program. But we feel th:lt we
ahall be able tt) Buhject prophylaxis to a severe trial. Alon;; the same line
of thought ot investleati~ in pure science I shall have a ot.anca later
ti de a Burvey on a small group of pure Ind1an~ beint:; worked by the
Carnegie in.tltuti~9 If' any intere.tlng flnd1r!gii relult lt may g1ve
us nlw leads for mvestigatl00 on a purely scientific basls •. But from
the .rnall samp11ng of tests that have beant aken from the new dreaf!eel
in the Guatemalan Army, many 0 r who. are Indian s fromthe b'3.C~~iiOoda it ls
l1y guesl that we ~hall find only a relAtively small number of cardlol1pin
pOlitive reaotors • . but a much larger group Ihowing positlve or doubtful
Kahn and Maazlni reaotion ••
We th1nk t l'Bt there is Just if1 cat ian, a gain for purely ccientiflc
realon., for oerologie inv.ltigation ofthe role of' the liver In the
false !)ositlve react ·JI'lI. For there i. a very hlsh Inoidence of liver
~ilSeaae here.
Know mg the effect of dietary detlciencies in the fjathogentai. ot 11ver diaease. knOWing the hlgh incidence of deficient d1et.
lmowing the 1noldenoe of chronlc and aeute malarla and the effeot ot
malar1a on 11ver dlaeaee, and knolti ng the high inc1dence of false posl t1 ve
re8.ctj.onl it e8em. that turthlPr Itudy crt the relatlm of tr.ese !actore
to the falae!pos1tive. 1s Just1t1ed.
AB we have ind leat ed to you b otore 1t Is our opinion • based on a growIng body of eVidenoe, tha.t the VDRL Cardiollpin te:stwlI1IJrov" to be ideal
tor u.e ln oountries such Be Guatemala and otherY hav1ns a1m11ar oonditlone. Thue we teel that a thoroughgol115 study of the rea@ti'3n Ihould be
o&rried out. Wlth sufflc1ent data lt should be easy to s scure general
aoceptanoe of the method throughout the latin Amerioan ccuIltrlea who are
badly in need ot a s 1mple, rellable method. Thus w~. th the: vast ~ount at
fundamental work to be done in experlmental ayphill. in man and in
lerology 1 t mould be ealY to Juatlty contlnuatl ~:, n of the .t~ even though
"e are not able to atudy aimple porph,yl.x1. a. orlginally platme4. But
we teel that at the aame time we Iha.ll be able to atudy prophyla.xl. by oth
method. and to lIubJeot It to much moro .ever. te.tl than thoe .. oocurring
normal l1.
81. no ere ly •
,,1.
K.
C. A
So f;r 'lC t~~e r:·6r diem iE cncerned, I'm E:ure (or almost 80) that sacha
·,.ill s t9. ~' re:~ ;]rC:less, foil he is Just as mucti entranced by the problems as
the rest of us are. We've forgetten e.tcmt the tbing 3. 8 a matter of
c~~nver5ad on, except for an occasicmal gripe, but still have holP~s that
s ,met l·1 inS \";ill be done about it. "or all t~lG service personnel l:s re
are hit, and the enlisted men h · vebegun tdl send t~.eir families i.O:ile
as they are un ~..,. ble to live under the cuts 1m :;u sed, and ths. t i s not right.
Wewou ld like a consultant, :md I hope that you will 3et dovin for a Vihile
in the Fall, I h~ve asked abo:..It the p ssibility of ro me time of f in cale
that iliese s parents send us the tickets to visit them in Florida. Then
IshoLlld
like a chance t.o cc·me to N.Y. to ,visit . the lab and to talk more.
.
l:.nough for n.;\v, as it is 18.te '3.r:: . I ve got to be up before 6 to get
t:·.:e urine samples frm our last inoculated group .9t the t..1.:.itarJ ..os::;ital
beforestarting their penicillin treatment to complete syphilitic ther~py.
Incidentally, we have inoculated for a second time 4 of the failures to
take in GC, BRaxX~., eitr.er controls or treated patients, and all carne
down, but the applic ati on was made 1/2 inch into the u rethra with pus, :3.U
all ad the di17ease within 24 to 36 hours after the applic ':it ion. I doubt
th8.t there is much immunity when .~:Oll go deep enoup;h aha wonder if it is
n ·:) t Just a matter of ho\'l dleep tC!9 change in type of epithelium takes pb.ce
in ditferent indlvdduals.
9ur best rearde 'bo all t!-_e Arnold vamily .
sincerely,
.
STATEN ISLAN04NEW YORK
CII'FIa OF DIRECTOR
VEJlEREAL IlI5EASI RESEARCH LAIORATORY
U. So MARINI HOSm"AL
September 8, 1947
Dr. John C. Cutler
Sanidad Publica
9a Ave. Sur y 15 Calle Oriente
Guat emala Cit y, Guat ema1a
Dear John:
I have written you an official note in regard to the
employment of Mrs. Portnoy and Mrs. Dalmat. About all that could
be said was to use your best judgm8"l.t.
I should like to add the
admonition that hav:ing people in an organization who cannot. be
treated with complete impartiality is always dangerous. Personally I would be very hesitant about employing either of the parties Il2ntioned.
1I..r. Jobbins is in the hospital here. I think that he
has the usual engineer's distain for the medical mind and the
medical approach. I am informed, however, that he my well have
a rather cOf:lplicated condition in the upper right quadrant.
Will keep you advised as to any progress.
I wish you would give some thcught to the future of
the work :in Guatemala. In the event of the prophylaxis angle
proving to be impossible of resolution, we will have lett. on1.y
the serology study and the work in penicillin therapy. We would
surely hiive difficulty in se1Ung an expensive project of this
kind to the Service. Also, a comprehensive study of the reliability of serology as a diagnost ic inst rument among aboriginal
peoples in tropical America would require a different approach
than the one be:ing used at present. We would be obliged to canvas the South and Central Anv3rican natives, the Mexican Indians,
the Indian tribes in the United · states and, finally J the southern
negro. A study of this type would require mobile teams capable
of doing medical work as well as serology. I am not at all sure
that we could make the necessary financial arrangements.
Please give me your thoughts in the
S:incerely yours,
JF}1:tcw
matte~.
I
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..
..~
STATEN ISLAND,4.EW YORK
OFFICE OF DlR£CTOII
VENDlEAL DISEAS£ RESUIICH LABORATORY
U. So MARIHE HOSPITAL
sept ember B, 1947
Dr. John C. Cutler
Sanidad Publica
9a Ave. Sur y 15 Calle Oriente
Juatemala City, Guatemala
Dear John:
Just a peI'sor.al note to <pen a sub ject that has not reached
the official stage at the present tire. It concerns the study of the
final phase of the prorhylaxis subject.
As you know, we have delayed setting up a field trial of
the prophylactic agent in the hope that the Guatemala work would give
precise data which would support, even in a smll way, the experimental findings in anirmls. From your reports both Arnold and myself
are somewhat pessimistic as regards the possibility of setting up a
ccntrolled e.xperimmt in gonorrhea within the range of the patient
material which will be available to us. Also, in syphilis, unless we
can trar.::;rdt the infection readily and without recourse to scarification or direct implantation, the possibilities of studying the subject are not bright. Both of the latter procedures are drastic, are
beyond the range of natural transmission and will not serve as a basis for ~he study of a locally applied prophylactic agent.
The Army now desires that we join them in guiding a field
study :in prophylaxis. The first inclination was to select field organizations in Germany. This has been changed to Italy. We have
agreed to undertake a pilot study, which, if successful, will be followed by a statistically sound investigation to be conducted entirely by the Army. The work of organization is going on but the timing
of the onset of the study is not in sight.
Arnold feels that either you or himself should guide the
laboratory's part of the show. This detail should not require a
prolonged stay. The work will be done by a joint commission of Army and Public Health Service men, with the Army doing the official
part of the job. Please write me your feelings in the matter in a
very frank way.
,
By the way, Arnold is now in Greenland on a syphilis survey of the natives who have been infected with s~~hilis as a consequence of war activities'-
Sin9icere~~.
JFE:tcw
J. F.
Medica
USi·HS
oney
Director
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01, ARISTIDES A, MOLL
June 5, 1947
D•• JOHN
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MURDOCK
Dear R 0,
'l'Onigbt. &boot an hour ago we tln1med the la.t ot the .erle. ot
another experiment, Wld I .topped by the 'tiler oUlae and tound your lett.er. fbl • • qa~l •• wbat we pya been hoping tor, tor eaoh 0 t tour night.
we have taken four men to t he hou .. to .e. tile two glrl. that we had PHpared 111 tb tbe tntectlan, and .ach mal bad a. manl trl.1l a£ he wanted,
mo.t ot them took two: at t.he a1xt.een mn one or tllO took only one trlal,
wh1le ••veral took thre.. Thenut .'.p, it th1s aDe. not. work, 11111 be to
.end the boy. to their !lou.e. w1th a note from u.. W. mall .ee.
Ot the la.t at udJ, ot 24 .1ngle e7.p08 ur •• to tbr••• wroe. ot ::1 tection 0011 1, lntect 'on re.u.t.d, an4 tha!. wa. In. one of the elght men
ex,=,o.ed to one source; all or them had had alm nol 1D drmk before the
ex'O.UN.
In t1 n ott1olal letter w. wl1l .md.:too the c anplete protocol.
But 112 any event 1t .eem. tnat tne natural expo.ure wltn the., men ls
rather low. ~erhap. lt :~ that the msn ~rel1ke rabblt_. Inthe gruup •
.clven two or maDS ohan ae., though, the •• 00 rd. try jn the .ame eveni ng
take. a good deal longer than two or four minute., run ,- lng to 10 or 15, BO
that we ma.y 'e xpect a fa w more lntect ., .n. tlf) ;.. t,.l..;o gr " up.
W• • hall coct1nu •• at the 1Ii&m8 11 me. wl th the experiment. utllizing
appllcat~on of pU5 to the group.
However to do th1D we llBve to' set our
group. &a.embled and haye to •• aure a donor wlth an lnfection .uti' ielent
to give eno~h pu..
In lhe la.t one that I did r;er.aally we had only 1
ot the three oontrol. intected. and 1 think t.hat the reaaon wa. that on
the m-:;rn1ng of the inooulat: en the d.cnor had vers JAtt2.e .eareti ,n , and
tUl-thermore he had had tor 10 day. at tbo three "eak. preoeed1ng .ulta
w!-loh wa. u.elea .. ln q re81 ... tant 11: ect 'i on.
I • • cut. ot the r\.llnlng tor about a week w1 th a very .eyere am
debll1tatH18 diarrhea whlch w••• 0 bad that when lt hit 1.18 1 nearly falntAl
at the dinner table and barely made it to bed under my own po.er. but 111
I am ~ully recovered and ~ at work.
w. aJ"e watchmg the N.ult. ot the two inoculat.L,n experlment. with
muoh 1nter••t. 'l'be re.ult. at the local arplloat10n .how nott-1ng yet. but
at Ju.t three weet. it 1. too .0011. 1be patlent. "1a.v1ng reoelved the
lntraoutaneoul 1noculaM on • ow a god deal rxr;re, w1th the majorlty .i-,owlng
papule. ot varying degree. ot redn ••• and lnduaat ~ .:n 3l'ld local adenpp.ath¥. W. bled the grup agaln ye.terday, 80 th2..t we may .oon have .~e
ch<:mge. to report. A. yw oan 1"!1ag1nl". aN all hold1ng our breath.,
and we are .xplaln1ng to the patient. and other. ooncerr.eci *~~ wlth
b ,; t a
key exoeptl n., ... tmt the treatment 1. a new on. utillzlng •• rum
t4llo"ecl b7 penicl1ll~1.
h1a d '. )\Ible talk keep. me hopplng at tl in•••
SundA,J we hope to reAch san "0 •• to work a galn 00 the ch1ldrq. the
read. penaltt.1Dg, md .,,111 .end lOU tne relult. oOlIi>letely worked up a.
,"oon sa po. I i bite. W. have begun wlth 1h e oJ'l)hanage, but i.a va bare ly toual
lt, 10 t hat ther- t. nothl~ to report.
t."
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June 22, 1947
Dear Dr. Mahoney;. ,r;. '
fhl. mornlng 'Dr~ spoto left for the United state., to a new
a •• lgnment 10 Texa. ·'the nature of whIch he doe. not yet know. w.
~ere .orry to .~e h~m go, but lt 1. probably better for him" a. he
.~. not altogether !~ppy here, the le ••• 0 .1noe hi. wlte'. health at
this altltude wa •.,orrylng him. Dr. beAn.,.le, hal reoelved order. to
take over the otl'1ce.
. :
I am w1'1 tlng', thlliil letter perllonally and unofflolally to a.k you
about .eTeral.Very important matter.. Flr.t, al you know, lt 11 lIlperatlve that tn." le,..t po.slble be known and .ald about thl1 project, tor
a few words to; the wr~g per.on here, or even a t home, mlght wreok lt
or part. of it. l'e have tound out that there has been more talk here
than we like wlth knowledge of the work turnlng up in queer plaoe ••
I thlnk that'~ll 10 the office reallze the confid.ntial nature, but
wlth hUlband.' and wlvel lm9wlng and wlth frequent .oc 1.81 gatherlng.
at which e.pecially lntere.tl~ topic. may be di.cu •• ed lt 1. qulte
a temptat10n to talk more than 1. tl ••• The four of,u. in our proj.ot
have oarefully d1.euI ••d the matter and allfeel t hat we IIhould do
all pe~61ble to keep knowledge of our project restricted. Tbu. I
Ihould like to alk your prem1.aion to .end the deta11ed report. and
dilleu~£ions at our work d1reotly to you and not through. any other
perllon here. In order to conform to the PASS requlrem.nt for monthly
reports we can c cnt1nue to send the barelt Bummarle. of oU' progre.l.
By the .ame token, any letter. dlreotly r •• pectlng our work mlght be
.ent to me through AFO 1f not urgent or else addre.sed to me at the
Sanldad .Publica , 9a Ave. Sur 1 15 Calle Oriente, Guatemala City.
But
routin, letters not of a confidential nature oan ~afely be .ent al
before.
:he other natterto alk about 1. the'extent of Dr. soper'.
knowl~dge of our project.
I mould like to kno." for my own information
but ife .ball tell him a • • oon a. he arr1T•• on July 7 that the Ie •• he
talk. the better.
When the program wa. originally .et up it wa. the plan to get the
volunteer. at the prdlon. and to pay th_. You are wellao'lu&1nt.d wlth
the rea.ona why 1t wa. nQt thu. oarr1ed out. Dr •• Fun •• , Harlow, and
I have oon&idared the mat~er oaretully and reel that on the baai. of
our exper1ence to date ' a~ onot our work a~ the penitentiary which hal
re.ulted, we feel, ln c~mtldence ln u., that we ,might approach tbe colo'
and then the priaoner. to ••cure volunteer. flr.t for more caretully
troled gonorrhea wor. and th81l on .,ph11i.. I feel that I can appri
colonel and the prlsoner. now on a more or le •• per.onal ba.1. with
'~..ullilon of our army experience and aay that we .tll1 have unan.wer
~~ whlcb could be an.wered there.
Doing lt opan~ In.tead ot
'Gr as we bad consldered would, we teel, glve UI .uch more mate
'r time in wh1ch to taka advantage of it. I . .11 take no .t
r.~wer, but I .~nQerely feel that wlth thl. approaoh we .hal
.... the long run, and in ca.e t~re i. oppo.ltion at any pol'
·,k traek returnlng to our orig1nal plan wlth nob arm don
It 1. Wltorttmate that .. e have to ..ork in woh a guardecl, .eD
.ubterranean ..ay, but It .eem. to be very neoe •• &r74
Both ot the rabbl t. whioh we inooulated w Ith material u.ed tor
the t ir.t .yphlll. experiment developed bll.a teral ayphilltlc orohi tl •
• ubaequent to injection ot one te.ticle with the materlal immediately
upon preparation and the other with the materlal at the concIu.ion ot
the experiment. l'he number of p atienta .howing .eroloSic evidence ot
intection i8 ateadl1y Increa.ing, and I th1nk that thi ,. comi1l5 week we
.hall have enough material to outline tentatively the re.ult, tor you • . .
We teel that the next atep ahould be a oontrol one wlth patienta t.vlng
poth po.itive and negative oardlolipin reaotion. Inoculated wlth norma!
rabblt te.ticular tl.aue 1n order to r.le cut non-.pecific .erologio
re.pon.e to the rabbl t proteln. Thu. we have .et up a group wh!lch ..ll~
be run wlthin the next tl.e day.. The lalt rabblt. that Dr. Arnold .ett,
are of no u.e, to r one died about two weeka ago; while the other haa to
date .hown no 11gn. of ftchlti., .0 that we can do no more inoculation
work until .ome new rabblt. arrive.Slnoe temperature, dlet, eto.
all intluenoe the inteotion do you think that It might be well to
keep t he animal there for the tlr.t three weeks ot Inct'bation, .endlng
it whe6 almoat ready for UI., but notifylng u~ well in advance so a.
to glve t1.me to prepare the group?
How that we have the . opportunity In the a.ylum it would .eem well
tor U8 to try the vlrulenoe of Dr. Wo Cloud. T. ounicull .train if you
80 de. ire. We oan prepar,e whenever 1t 1s convenient tor you.
In the la3t gonorrhea experiment utll1z1ng natural expoaure we u •• i
two girl. over a four night period with feur men exposed to them. Eaoh
man bad a. nany oont,aot .... he wanted dur1n j the evenlng
that the toL~
tlae ofaxpo.ure averaged over ten m1nute. with moat ;:: en having two and
.ome three expo.ure.. There. amo doubt of the pre.ence of the gonococc.;j
in the women, a. that was proven culturally tw1~e each night, but atter
two week. of obaervation no lnfeotlon developed in any ot 16- men. It mill
be that the inteotion bad gone too long in the source., .0 that we are
getting ready now to expo.e our men to the Inteotion a5 early in it.
oourse as poa.ible. At the .ame time, or in the next rl.m we .hall u.e
alooaol a8aln, for to date our only sucoeas haa come In the ca.e ot
a man who had had alcohol prior to expollure. It. ..... that clande.tine
affair., wlthre.pect to gonorrhea, are .afer than ever before imaglned.
There i. more orammed into theme two pages than ought to be, .0 t h :;.'
I had better stop before tiring you. Eli ••• and I both send our very
be.t wl.he. to you ani lira. Mahoney and hope that you arew ell.
Slnoere lJ' .
.0
U. S. PUBLIC HEALTH SERVJCE
STATEN ISLANO:4NEW YORK
OFFICE OF DlRECTOII
VEHEREAL DISEASE RESEARCH LAIORATORY
U. S. MARINE ItCSPITAL
May 5, 1947
Dr. J. C. Cutler
P.
o.
Box 383
Dear John:
(Through Dr. Josphe S. SpotO)
I was more than pleased to have your last note together with the one trom Portnoy. 'l'hCf' cause me to teel assured
that the work in Guate.ma.la will not have to undergo the agony ot
~ersonnel ohanges.
Please teel sure that we will oontinue to do
anything possible to make the work more agreeable and more protitable tor the members of the unit.
A new angle has developed in regard to whioh I hope
that you and Doctor Spoto will make a mental note and then destroy
this letter. Dootor Van Slyke made a hurried trip trom Washington
recently to tell us that llarry Eagle is about to complain to the
Surgeon General that I have not been extremely enthusiastic about
allowing him to enter the Guatemala study. As you may know, he
has done oonsiderable animal work in prophylaxis in syphilis by
use ot penicillin and can only prove the thesis by a human experiment. He discussed the matter with me several weeks ago but I
could not see wherein a study ot that kind would have other than
an academio value it an injection technio was employed. I thought
it would be ot still less importance if an oral preparation of penicillin was to be studied as a prophylactic agent. Further, I do
not care much about having anyone join the stUdy who could not
share in the responsibility tor the entire program. We are
soheduled to have a meeting in Washington later in the month, at
which time the entire matter will be discussed. I shall intorm
you as to the outcome.
Vie also gather the impression that Doctor lleller
would feel considerably more seoure it we were to set up an advisory group of leading figures in the world ot science to serve
as a background tor the study. I have never been a believer in
this type of thing and I do not think that an advisory committee
would help us greatly, but we might have to deter to political
expediency. There are several men whom I would not mind being
aSSOCiated with the work. There are several other leading
figures wilo, I think, would be a distinct detriment • . W11l let
you know how it all comes out as soon as possible.
- 2 -
Dr. J. C. Cutler
May 5, 1947
Again, with kindest regards to all, I am,
Sincerely ,rours,
We are returning the manuscrip-.. of the paper which you
presented to the Guatemalan Medical Society and which has been
approved 1'or publication.
IJ.S.
JFM'
JTM: tcw
December 21, 1946
Ca.aatiD« Otflo. .
U ••••• Air Ba••
San Jose, Guatemala
8ir&
Oil Satura., AIld hIl4eJ ,Dec_b.. 14th _d 1f5~, \h. Medioal tech- aiel • •t 7(1V ]Ia ••
bloo4 eMpl •• flo. fo04 baa41.... th. report
of \he ...olOClo tel' for Q'PhlUI pertorae4 OD apeel.ena numb.. oa.
to .ipt vera all cOlIIple'.17 • .,.U•••
,.ak
Oil the 4IJ¥ before Dr. Helll7 Scholttner. frOIl tb1! office, had
'blood lamples from tWlIlt,v tlv. of the .ea .,.tloned at 70ur Baa"
unfort1Ul&tel1 wh.D \he•• aampl •• v • • bella« centrUtace4 there was . .
acel4ent 80 ,bat allot the tube. were
aa4 &11 the i4enUflca\101l
lla!'k. vert lode JaCJQCh II.8ter1al . wal obtained fro. ... eral tufte,
althouch the tube. ooald Dot be 14811.Ut1e4 to run 'eetl, in two of the ••
tub •• a pOliti•• lerolo.l0 t.lt for "phlli. yae taund. ~qu1pmellt baa
beell .at to 'Tau .ediau technician to take repeat '''-;Jles trom all ~
the .en 80 tha' 7Cftl .., ha•• all the laformatioD tor your recor4••
tak~a
_ok_
John C. Outler
8.A. Bare'oa, 17BPH8
JOI.-ph 8. Ipo,o
Chief, Cari'b'beaa 8.ctor
_I
IUIIII_ DC 11II1II01
.'IUTOI
V1C1D1HCTOI
D. JOAO DE BARROS BARRETO
D•• HUGH S. CUMMING
DI. JORGE BEJARANO
,~&,
'IIS1DCIITI D(
110 III JAIIIIIO••• WL
COI.OIlIIA
OFICINA SANITARIA PANAMERICANA
D.. C. E. PAZ SOLDAN
UNA. '!IU
DI. LUIS GAITAN
COIISUIOS
PAN AME"ICAN SANITA"V BU"EAU
DI. M. MARTINEZ-BAEZ
M'lOCO. D. ,.
SECTOR DEL CARIBE
UllIALVADO •• 1I. SALVA_
CENTRO DE ADII!STRAMIENTO E INVESTIGACIONES
DE LAS ENFERMEDADES V£NEREAS
D•• ENRIQUE CLAVEAUX
APARTADO NO. 383
DlKCYOI AUXILIAI
DI. JOHN R. MURDOCK
SKKTAllO
Dt. ARISTID£S A. MOLL
DI , VICTOR A. SUTTER
GUATEMALA,
~D(O.UIU'UAY
GUATEMALA
16 de diciembre de 1946
Dr. J'ranc1eco BBlasar
Bub41rector de 8anidacl
Quat_ala
:II timac10 Dr. Salasar :
Suplico a ulted se lirTa tacilitarnol leil (6) litro.
de alcohol parento del Centro de Adieltramiento e InTeatigacionel de la. Sntermedadel Ven'r ....
Dmdole lu gracial, una Tes
u.
por tOdaa
lUI
quedo de Ud.
.A.tentemente,
John C. Outler
Jete "del Labor.torio
atencione.,
Me41e81. Dil'eetor Joba •• JIahoa.
s,.t.
I alall4 'f. D. • ••.arch LUorat0Z7
U. I ••mlle .o8pl 'al
Stat. Idaa4 4, • .., York
Deal' Dr. JIah• ., I
"1 th th. nae ot th. eh1p o8l"!71ac oar .qIllpent ill 11'.
Anlol4.l • l.tter of ho_bel' 12, it will 'b. pOlll'bl. tor •• '0
expe41 t. th. ahlp_at fd our ...t,._t. 0.. of '\h. croup . . .
will . . ,. - " , u M Uk...... ot 1'.
Ifbere 1. aal"_ tOl'll 13••0. 71 (OSO) t .. .... Be J.u.e.
Dr. 'fl11.l.. th. Chi.f of the 'feaereal . . . . . . »in.l_ of
Bealth l...ne. h pl.-SD« a ••eUac of ~
.woa Tawea101act.,. 1.11 .moo 01\7 ar0aa4 \h. 1I1~1. ot
:r.'bnar7. •• Ipo'o veGl4 like \0 srraac- 1\ 10 that 7f¥OZ par\7
can
OIl \be viti tra. the other •• etlac _4 a4ar ... 'b•
111lc. Dr •• Bell .. , "014 ea4 ' f . 817k. . . , . yUh 7-. t.h. . . alP'
'b. taar _\horlt.U,•• 8p~~U ct•• _ GO.ll . ., procr- tor th•
.A.,oct.'lOll. 0_ it 1Ht an...."
Aa.oaa as Dr. Spo'o 1m... h. wUl
" . .ill to . . . the _ee".87 arruc-_h.
the
.cda_ ,,'bUo
.-eap.
.'op
'hoereq,
Job C. 0a.t1 ..
I.A. Burae-, tJ'8PIt8
Jo.eph •• Ipno
Chill, Carl1tb... leatar
'-
RAN "MERICAN SANITARY BUREAU
OflCINA SANITARIA PANAMERICANA
Date I
>f 1cf ,
Referred for action checked to
(\,
..........__ .. s..!..::_._._ ....&v~1'_._ ......•.•_..._.•...• _.•••.. _ ••••.. _..•..........•.•••••.. __._-_.••
o
~pproval
aYAttention
O· Comment
o Consideration
o Correction
o Filing
o Initials
o Memorandum
o Note and forward
o Note and return
Remarks:
r-,J6 .., ,.
o Note and file
o Previous correspondence
o Recommendation
o Record
o RUSH
o
Reply for signature of
0 See me
0 Signature
0 To be rewritten
F
';>"LI~~
~V
\:
~
; ~ ~
...............~..................._.............................
(Initials of sender)
tU ...CTOIl
V.CIIDI .. IICTO ..
DR. HUGH S, CUMMINCi
DR. JOAO Dit BARROS BARRETO
DR. JORGIt BIUARANO
'lIO 011 .. ANEI .. D . . . . A.'L
.OOOTA, COLOM.,A
MIII ..... O. 011 HONO ..
OFICINA SANITARIA PANAMERICANA
DR. C. E. PAZ SOLDAN
CON .... II .. O.
PAN AMERICAN SANITARY BUREAU
LI"A,I"II .. U
DR. LUIS GAITAN
REPARTICjAO SANITARIA PANAMERICANA
GUATIIMALA
OFFICE SANITAIRE PANAMERICAIN
DR. VICTOR 8UTTER
.AN .ALVADO". ilL .ALVADO ..
DR . ENRIQUE CLAVEAUX
DR . M, MARTINEZ.BAEZ
"DNTIlVIDIlO. U"UGUAT
W'(SHIHGTON,D,C.,E.U,DE A.
MEXICO . D.P.
DI .. IICTO .. AUIt.LIAII
SEC .. IITAAIO
DR . JOHN R, MURDOCK
December 12, 1946
DR. ARISTIDES A . MOLL
Dr. John C. CUtler
P. O. Box 383
Guatemala City
Guatemala
Through: Dr. Joseph S. Spoto
Dear Dr. Cutler:
We ere in receipt of your letter o't
22, 1946 requesting permission to extend your
authorization to cover sueb places in Mexioo,
America and Psnsma as may be necessary in the
of your duties.
November
travel
Central
execution
Before deciding this matter, we requested a
c anment 'from Dr. John F. Mahoney as to whether or not
he felt that such travel would benefit the Venereal
Di.eaae Program due to the 'tact that all travel reimbursement must come from the Venereal Disesse Grant. A copy
of Dr. Kahoney's letter is attached tor your information.
In accordance with Dr. Mahoney's negetive reply,
and the rapidly depleting grant 'lunda, it is regretted
that we must deny your request.
Sincerely yours,
~.
~
/ ./~4 J." ~
' . 4'
~ugh S. Cumming ~ ,
iii Director
Enc. 1
df
C
o
p
Y
U • S. PUBLIC HEALTH S»tVICE
STATEN ISLAND 4, NEif YORK
December 2, 1946
Mr. I.e 0 J. Van Herpe
Controller
pan American Sanitary Bureau
Washington, D.C.
Dear Mr. Van Herpe:
In reply to your note of the 29th, it would seem
inadvisable to grant an unlimited travel authority to
Doctor Cutler if the expense of such travel is to be borne
by the graat-in-aid fund. These tunds were made available
tor a specific purpose which centers in Guatemala and
difticulty would be encountered in justitying expense
incurred in travel elsewhere.
No objection would be interposed for Doctor Culler
being of any assistance possible to the Pan American Sanitary
Bureau in other Central and South American oountries provided
the travel involved would not interfere with the conduct of
the Guatemalar.project, and that the expense inv~lved be
defrayed fran funds other than those earmarks d tor venereal
disease work.
Sincerely yours,
(SGD)
J'. F. Mahoney
Medical Director
usrus
J'N:tcw
STATEN ISUIoNO:'NEW YORK
OI'FIC£ Of DIRECTOR
VENERWo DISEASE RES£ARCH LABORATORY
Dr. J.
December 12, 1946
c.
Cutler
PBS 2103 - A.PO 839
cf0 Pos tIII_ ter
New Orleans, Louiaiana
Dear Joh.u:
Your letter of November 22nd regarding serological spec1mem was mi.plaoed aJIOna 80me papers on my desk.
It mar be seTeral aonths betore a serua survey
will be coDducted so it i. not possible to oheck the laboratory at this tiae. However, occasional lot. of serum.
sample • .!lay be forwarded to ,Your laboratory tor 8DIIlination
as an interlaboratory oheck. This w111 DDt be considered
as an official evaluation.
Sincerely.
-ne
R. C. Arnold
Senior Surgeon
USPHS
RCA: tow
STATEN ISLAND~EW YORK
OfFICE Of' DIRECTOR
YENEREAL DISEASE RESEARCH LABORATORY
U. S. MARIIE HOSPITAL
December 12, 1946
Dr. 1. C. OQtler
PBS 2103 - APe 839
0/0 Postmaster
New Orleans, Lou.i.iana
Dear Doctor CQtler:
It is regretted that the eqQi~ent has been delayed .0 many ti.... As YOQ know, the last delay was
caQ8ed by ship being PQt into drydock on the scheduled
day ot 8ailing. 1Ir. Morrison telephoned 1Ir. 171e today
and learned that the PAN CRiSCD'l' sailed December loth
with the eqQipaent on board.
It you do Aot D8ed Albert DeLas•• atter December 20th he JIl . y return to this laboratory tor turther
sigDJllent to dQty. It is believed that his original or(.ers lIere written 80 that he was to prooeed to Guatemala
City and at the te~1DatioA ot duty there he was to return to this station. No objection to three w.eks leave
en roQte will be raised: by this ott,ioe. A letter covering the .l1bJeot haa been written to Doctor Heller.
a.-
Doctor 'Mahoney'. presentation ot the 4OxB5
sohedQl. was well reoeived at the Der.aatological meeting at Cleveland, yesterdey.
Sincerely YOQra,
--?8¢'.
R. C. Arnold
Senior Surgeon
USPHS
P.s.
~ere is enolosed 10rm S.F.No. 71 (OSC) Application
tor Leave. Mr. DeLasse shoQld .ign on the designated line
and return the slip to this ottice 1. .ediately.
Deca1»er I, 1946
IIe4lcal J)ireetor Jolla ~. IlahOD4!CP'
lta'_ 1.leal Y. D•••• eareh J.abor.t0!7
11. •• • ..lae Dep1 UJ.
lta'_ I.lad. ., W. T.
Dear Dr. .UOIl., I
'0
h ':".. YR7 aem lluppo1a'., apoa arr1'Yal 1a hvto Barrio.
t1u that the .to....., wu BO' _ 1»081'4 ot 'h. M1p vhich had 1.t,
.ew TI11'II: OIl
Bow......
.OY_~_ 'h. ro'll.
vhile v. aer. there we le8l"llec!
Ulat \he ezpec'e4 nrik. hal be_ ••,Uel 'f_ ., le••' thlrt7 aq. . .
that we u:r .U1l cot Q. e!dpaa~ It.tor. tu
liDe. Ibea U c • •"
GIle of u
vill acata .. t. heno :Ian1.o. H olear
at't. wh10h U call c. .
QaateuJ.a
recalal' 'fr.1ch,. 1ucJa •
•• th... vil1 • ..,. &MIl, u.r. . . . . U ...
at_ •
'0
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'0
ta.nr.
1, rill b. vel1
cheok wi 'h Mr. 1T'f.
_'mal ... aeftal17 1>l8A.4 OIl b08J'd aa4
$0 4A..-l•• til. _ . _4 aell~
of \he eJdp. I. vere
'lie 1JalMi J7td, ac.p..,
\a, tr~t17 .hlp_eah v ... oODdp.'
'0 • ehlp 011.17 '0 'be 1'..,...1 or '0 1». 0 • • •11., ., ,_ 1.., ___,.
I thbk \hat b
U
\he
'0 . .cmala ".~*~tha
.Ac-' Ia'.
'01' '"
!'a• .-ple. t4 1UIkod .... 'for , .. Uac 1IJ'ri'Yel 'h1. 1IO!'Il111C a4 are
lac
the lahr.'oJ7. 1IuaIk,• •..,.um tor • •41q thea.
v. are ooa'ladq ear work of \he ...01 oct 0 Wlll'Yer o'f lbe peat. \_U~
an4 are 401ac .aall .cal. vort witJa ~ the " . , aa4 Dr ....... hoep1\al,
.0 that the _ . are Y.f7 tulle
AGW . .
tI.a.
,1Ir__
Y• .cwe4 iat.
bu.•• two v ••• ap 1ID4 8I"e tlaal17 ae\Uac ••,-
OIIJ"
'0
YOtl will probdl7 v ..,
baY. ..e olo~ -.4. 1n the aear ftlhre.
It 7ft _ vai' _U1 , . arr1y...... U v11l 'be po••1b1e
cet t~
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OOAet.Ura1t~
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of 'h1. aaaUl _4 Uuaret... I Uoal4 Uk.
4 hi. back 11.• • 'bea •
.. hu r.q1le.,.a 'lIr.e v ••• 1 ..... _ roa.\. i . . .t.r to .,,,, vUh Ill.
t.117 la .moo 01". l)aan tileret• • t.14 hlII tha' H
an-ce_.,. tor pu.ac., coa••t(Q._'~, u vill amy. la • • Tart _ _a th. 10th
fit J....".
1ft11,. pl.... i.n. or• • tor 1l1. to lean her. _
or . ' - , ~_b_ 20.
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.... '0I"U1 ..., haa the 1&,,"*,U017 1'DD1. . . . ,hat h. 0_ 40
& e ••14..alI1. "1,..• • t YWk.
ta I.i-. oheok '.,U. . ot dtrplloat •
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• • ..". 'be ....loQ labora'.., .f 1_14&4 ""11... ¥a Iaan taut •
'YU7 .....,
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ft1"
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t..
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••••, tr. ltat .. 1.1...
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vill a . l•• th• ..-pl •• _ ~• • •0 1Ir. I ' '1rIIIl11 pJ'o"~ " •
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tu._
·17.
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••tlpeot~17 t8l'V&1'4e4:
Spo'.
I •• eph ••
Okl.,. Carl'b... loot_
.-1._
\
·.ucal Direc'or Joha 1'. Mahoatr
8'a'_ 1.1_A W. D. . . .urah J.alHJra'ory
U. •• wartae Bollpl tal
Sta'. l.laa4 4, I. T.
'0 ,..
I - 41c'a'1Dc ,h1. leU.
fOl'Yl!ll'Ae4 yUh the ,,~ ..
for "a.bUcaU_. I' rill b. __ , _ .0011 .. the 'nIlD« 1. fill1'h....
IY. 'houp I shall IlO' 'b. here a' 'h. '1.., J 811 un.._ '0 C., 1t
to
la a IImT7 dllce \he .eare'U7 .t the ".Ueal MMOlattOll
waah
haY. 1 t . . .ooa
"po•• lltle. ~ ch"..•• ,bat
_4 Dr.
ArIlolcl 1UCt;.. 'e4 ha•• "eell aade, laoww_, U . . .tl11 be ctCIIl4aM4,
vll1 7" be .0 klllel al '0 • •e .., fur'her ch8Jl«M tha' ,... .e. fl t,
,b_ fOl'VU'el l ' f,.. a'P'PrO'Yal ri\lloa.' _.4iac l ' _ _
.e. la 'he
1e't. fd ..laa11110a. rill ,OIl pl .... a4tl the UU. 84 '.l1naUaa
of _thor u 70U A.dre 1'. WIt. 8pTlroyel 1B r~ 'h. '1'_81..-1(8
1.'0 Ipaal.h w111 "'Iloa. _4 'h. _.crlp' will tbe 'b. cl.e. to
'he e4hor of 'he Jnraal here. I ao aot vaat
uk 1Ir.
40 ,he vea.1aU_ aUl 'h. WBcllah .era101l h oOllpl.'.17 ..Ud__
'017, a. 0'herw1l. 1 t .houl1 .... _h atra work for hl.. la the
'r...laUoa the .tnotuJo. of
'ee •• wl11 be oOllpl.'e17 chaztcea.
1n M'd.. \0 C1. . . .
lU ...,. rath.r thea 11
'raaalaU_.
011'
'0,oa.
a.
,.ft
'C
".1- '0
'0
lIDO'
,he ••
,_aJ.
!!w \raaalaUoa of the .aual of Oaltiy.Uoa ot Iftocecn. 11
'belDC yorlt~4 OIl ...., 111'. loJ •• aow ,hat Dr. J'Ues tlall1lea hl. __...
laU08. !be 'laa! 'Prep..a'101l ot a «004 tJ'Nllla\loa 11 rath.. a
10D« proo •••• a' .....0Ju 11 WGI'ttln« a. rapi417 a. Ile ca •
• 1ac.r.17 ,
John C. Cutler
•• A. Iur«eoll. 1JSPII
•• epeeUul17 to!'War4ed,
30.eph 8. Ipo'o
Chi If, CarlltbUll S.ctor
lCC/. .
.,..
/
Oo'.bel' II. 19"
Dir.o'.. : _ r. 1C&hea.
Ita'. 1.1.4 T. D••••..-ah t.abol'.'1117
.e4loal.
17.1. llarill. • • .,Ual.
t.l.4 4. W. Y.
I'.'.
DHI' Dr. IlahOlltlr'
b,..,
I_ 'h. 1.".. fit lep,.b_ I. ". •••, fer . ., ..ial t . . .14
pr..tlq f . 'h. 1• • •,.".
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it • •, haY. , • • W, ........ IILI"lac nrtk... w.... u.abl.
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1Rl4,ft pl. . . . . ., dnatl ,. 'h. 110
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f - . l a vhlo~ ¥l11 b.
, . , . . . . . . . , MIl' 'alIl. ' ' ' ' . W.itU:r Ih'. , . . . . _ I Dew 31let
how . . . will b. r..ul'et. ht 1Ir ......la .. 1)1'. ftaJer wtll _4ftbte4l7 b. alIl. ,. '.11 ... .ah
eha11 •••t.
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, ••t. It,ew.!tan 100 .. aoo ..., , . . . .,... u -. 1_ we _h lipJl'M1M.7- ...4t.. . ua_ lip IIlr. V. al. . . . . lao1dDC 'Pip."n_ if 7haft .., 'h.'
.-14 lea4 , . , . will pl.... 1.' •• Dew vIaa' .t•••
a4 .-UU.. 7- ... .,... , . _ • 1 _ . .i •• .
•'''ik......
,ft
!a)._'.,.'.bc'" •
th.
.ew 1. a1ao~~ a ...l ...' •• ,hat _ Moa4Ir J ••
aplO'. , . . . . .,
1ft , .., . . . h. hu It. . ,...)1. ,. blprm ••
• ,,04 4M1 wl~\ 'M ...1,..,· ,bt •• b i b \h. fir" ahl~_'.
'na' a
l1el.. at I hIIPe 11_117
pl... ,. 11. . a4 we vill .....
~. '-.rIV. -lhe • •a. IMr kt.a'..' 1". . . . . . tv 'Nth , .
at 1Ir.. ».1 '.oe!a1••
la a w••
'."'17.
I . . G. GaU •
...... ........ 1JIPII
l..,eedll111 ,.."...,.,
J • • • • • .,.,.
a-Utb......, .
~."
...
.~
Oo,.b«r
1.,
1941
Dr. I. a. B.ller, Ir.
KeUcal ])treet.!'
Ghiet, , .... eal Bi ••••• D1ridoa
1Ja1 'el "a'•• Publ10 ....Uk
" ...h1",-_ 14. (I.'h.... "a)
,.me.
ft.-
hbJec' I a'flU.d tor 'h. v_dati. otlfrecNU ...·_ .
t . l.olaUoa . , Ict..'1I1.'101l of tlae "oc..
It... Dr. Bell ..
1.'0.,alD
Alt.,
_Moon.-
tho till' 70ur 1.,,111' ro..,.•• U .. 'h. 'r... la'l011 fit "h'"I.'_~ .
tor 1•• laUoa &a4 U .•'1I10aU. of th.
ha4 am•• Dr. JIa •••
a,ueh., \0 tu , ... Ml Ill.... ProJon 1. ""lUla C1 •• W. e...,l.,o4
'h. 'ru.laU... A' pr •••, l' 11 bel. . .err • •ct act r-n.04 . , a oow
will b. tOI'V&l'I.4
7ft y1
tho ••st . . . ,
'0
'hi.
th. WOft ot ec.pl.t1q 'h. la'Hra'ol7 1. alae., t11l1Ih04. "Uhb. a • ..,
Ihor' tb. YO .hou14 bo able ,. t .....lecieal.
oa alias. ,., .eal.,
11loroutllC th. work •• th. r .• • t ., th......1,...' arr1••••
""be
W. tinct tho eouatl'7 ao.t pl ...... ' ,. 11•• 1.. fIL. uU•••_1101 . . . . .
h.lptul.. V. ar. 'looklDC torwrl , . . . . 7ft h . . . . . 'he Y'OI'Ir 1. v.ll
ud.. vq.
~
III lrtIlU.' recar4. '0 7tIV
"aft.
111l0...17,
loha C. CuU.1'
I.A. Ive"', 1JSPII
••sp.o'tal17 torvarl.1
"111 ,.. •• Dalh1ol.1
701' 'h. Ch1ef; Oar1bboea '00'01'
100/__
eo Dr. Jola I. JIaboIl.,
.,
•
I
r4
•
•
I
J
5
·~
FEDERAL SECURlTV AGENCY
WASHINGTON 14
1N ......Y1NCI
(BErn£SDA STAllOH)
ADDIIIa ntE IIURQI!OH GDlERA1.
u. .. PU&IC HElU.TH IIERVICIE
jugust 28, 1946
.TOI
Surgeon Joseph S. Spoto
and Surgeon John C. Cutler
OficiDa Sanitoria Panamericana
.lpartado 383
Gaatemala Oit1', Gaatemala
Subjects Request for the translation of "Procedures for Isolation
and Identificatton of the ,Gonococcua" into Spanish
There seems to be considerable dBmand for a Spanish language tran."
lation of the 'Procedures for Isolation and Identification of the
Gonococcus. II Dr • .Arnold, for example, needs the translation for hiB
students from Spanieh-apeakin& countriea. Doubtles8, also. such a
tranalation would be useful for Pan ~rican Sanitar.r Burean project8
and such programs as are now be1nc orgBDiled in Ouatema.la.
If it is possible through TOur joint efforts to arrange a translation
into Span1eh of thh lIl8nual bT consultants or statf members in TOur
program, 118 would deeply- appreciate TOur arran&i.ng to haTe it done
as 800n a8 conT6nient.
-,..
Dear 1Ir. " r i. . .
1 Ju.t 1'. . .1~" 7fti' l.t,.. - , waa •••, U,W t. h... tra. 711&1 I
.1IIar.l7 h.,. Utat 7ft Iaa'r. ~ ...... .u rnu.1 nosti_ . . tJaa' 7 •
........ Ment • • ere v.ll.
u 1
1"_ _' - .
.,..., \1M ".,hft .u.l.1 '" C.tU. .
IN' let •• . ,••• , .. 0.14 .. t. '-th... 7".
"14_.
-.rrt... •••M.,..,.
~ '.lCl'. HtIr ... . . , ,. h11 7 . W 11••
,. I . I • • recutre fHa • , . I . . . . 1...... aa4 \h. . .ttea J'rdl Mr •• .,
,bat thl!F are aoe~'1ac .ldp. .t. tr_ • .., Toft. I tdla11
to ~. . . .
. . . til. Ihlp.u., . .taca 111 tM APpli . . , tv 1a •• 'olac we .hal. ",. able
a.
,. an •
1Ila1,.., _ \M l'aU.
s.oU.t.17 ..... aha1.1 . . . acn:pl • • t
ottt.
here
a 'n inf'1lluttal
" . . . wit. 1IJo. bj••• ,,..
... the .ttlo.. at the
Ull• •
'P""-
has
trt.Aa
t .bal1 ... Joe , . . . . ,._ a oh_,,..re1era'b17 a 4~o.1' •• vell.
_ th• .., wUll I HIl17ft" aonI 'IlLIIIIb"",., _oh tor all., __
¥Wk, t. 'II... ~th~ \hat
0&11 • •, tor ,..... here.
w,
kMvl....,
As I ranb .. , -u.n.' . . .Ur. bla ca..a 1. 1& \b ••b1'D..Il' 00.1....
1. \hat rich' UCOI'Iu. , . 70V
I _at 1 . . .
•• vi11
ca'
'1l1l
'0 pt\h-s.l
....
.. the ;>1&. ltaok '0 Yuhl",oa ....
., the all" b .... . , \M "sr, tatu O1l)a.t
~
ut.
""_tal.
.t 'h. ".. .ad
t . 11. t. 'a •• 1• •atlt.. \ht• • '0 7W wn.l4' ....
p18s•• t1lO1...... oweral . . . . . . ., u... 1.bl•• t_ ..utili ooa'.l.... at.....
with the 1. . . . ebeN' epeos..... t . btllO«ioal __ t . .Ucm.
'h.
JlU . . . . . . . . hIlld1l4.., rec~" _4 'he aen ,bat lh.e vi 11 , . ' "
waaldac ~1.._ • •, , .
~ t .. waII& ... ter '\18 at •• t . til.
'........ .,.. 7 - 'Pl. r • • • •1
wttll 0 • • fYf tile obi"• •,.,
,u.
.~--
FEDERAL SECURITY
AGE~CY
STATEN ISLAND. NEW YORK
OFFICE OF DIRECTOR
VDIEKEAL DISEASE RESEARCH LABORATORY
November 4, 19J.b
senior Assistant Surgeon John O. OUtler,
Guatemala City, Guatemala.
Dear Doctor Outlerj
I haVE just returned from a vacation in the south and find that I
really have lot. and lots of work to do, but first I want to write
to you and give you all of the low-down on everything pertaining
to the shi~ent of the balanoe of your equipment and supplies, so
here goes:
l--APproximately 22 cases, including transformers, will move out
of this station sometime this week. It will be necessary to ship
.via the pacific coast as the Puerto Barrios port is now on strike.
2-Practuallr ever~.rthing that you will need is in the shipment, and
I will forward you oopies of manifests and instructions when the
shipment leaves New York.
3-There will be two gallons of Black Acid Resistant paint in the
shipment, we have DO aniline on hand and it is just another_
product that is out of the market for the present time.
4-Have Portnoy send me check to cover screen wire, for I had to
purohase that ac;air..st my own name ond it will be in the next
ship1l1e nt •
5-All of the other 11 ttle things that you have asked me to do will
be attended too, just as soon as I can see the back of my neck.
6-Doctor Outler the cond 1tions of purchQsing any and all materials
and supplies at this time ~ Qre worse than I have ever seen it
before. practually nothing CEm be had Elny more. It is hoped that the
passing of O.P.A. will help the matter S)n!e, but the country has a
long way to go to oatch up, and I personally feel that it will be
at least two years before we are back to nOrmtll under the very bewt
of conditions.
7--In the next shipnent you will get lamps, pipettes, bottles, sterilizers,
CUlture Tubes, Slides, Cover GlassesjVs.cuum Oili Tubing, Gloves,C'.llture
Dish holders; Beakers,Orvus, Oavutainers, Shaking nachines; Baskets,
tripods, water baths j Oulinders iDessiccators, Coat s, Connecting tubes j
P~pette Boxes, It.iiscellaneous drugs, your camera parts, numbering
mao~1ne and other miscellaneous material.
•
0f1'lCE OF DIRECTOR
\IEJIEREAL DISEASE RESEARCH L4I1ORATORY
u. S. MARINE HOSPITAt
•
8-There will be not much left to come other than scattered
i tams, which will be coming I hope in the next 30 days.
8-G1ve my regards to all, and especially to Mrs. Cutler and
yourself', and let ~e hear from you and I will do '!:'-1 best
to keep you mGving once we Bet the material there to start.
"--~SOJl~~
Administrative Assistant, USPES
·'4l."a1 D1r.. Ur .r.ba J. lIMoaq, USPH!
......&1 D1 •••• e •••• arab Labora'."
tr.J1. lal'b. HO''Pi tal
'tat .. leland 4. .tTI
fhaDk 70U fer your l.tter of '.p, ••It.. 12; 2: v.. «la4 ,. b..,..r a'b01lt the
!h. 4q atter 'h. 1.., l.tter I va.
.hlpp i nc IUuaUoll and about the .qUtplB.t.
able to ..., 'h. 411""\or .f 'h. . . . .lec1cal lalIoratol7 h.r. f.r th. t1r.' U....
Mel 1a our ••• tiac va. able to borr.., a lIod c1eal et -.a,il)...t thElt ve Deel.el.
f.r the f." remallliD, u ••• 1
t. 'he US'PHS qutaruUlle .fflee!' ill theCaaal
Ita. alkiD& if h. could pr.eure the few
f.r u.. W. tar. l18kiJa« ~r.I1""
iD the 1aboratoJ'7. th. eo•• tn.Uo. 11 -pr.tty vell ~Ollll:. hawtil- the viedo. cla".
vhich arriTed to\!p.y froe ••xtc. cae throuch i. YW'J poer .ha:ol vi.th 1Ill1 aboa.'
a 'hird. of it uw.ea. W•• hAll . r l . lDor. an4 'hall ce ab'd. I'Yft thoqh v' • .,
hay. t. u.~..,er ... _.ya, fft ••m. et the pu... ...t \h. rat. ,hat thill" are
,.iDe we =-¥ b. able ,. lIperat. wi thill \h. au' 'v. er ~hr.. v . . . .
wr.'.
it._
111"'
"r.....
111'. Por'a., fOUlld hi •• elf a hou.e todq and .hould be .bl. t.
wi thiD the Dut w. or tbree week., ~"er we are .Ull 1a 'h.
l.okla,. haYi., faand Dothi~ ,.tisfActGr1 ,.t.
1.
.f
17 nov 70. .houl4 hay. . .de the ..daretll! reporUac •• th. "rep"" .f ftJ'
treat..., .e~aul'l alV 1. us.. 2: hop. that the let'.rl .ad n.r.onal .tlor'.
were luc••• ful i~ briDe tac in .nO'l1gh paUeDh to Ii••
a .eri •• of """
a huD,4red
'he . la,' .ohM',l ••
,0'(1
0,
.
,
'l
I.th lIU •• ad 1 • •el eaJ" rqar41 ,. Mr. Mah. . . . .4 t. ,1-:, • • there .t
'h. 1aMra'.rr,· ... v. look fwwarl ,. IHin, JOU u4 Dr. Ar.old i. 'he Il.'
ti .tot t\~ur ••
'0.
/
/
,I
Tour •• incerel7.
.r.ba c.
/
Oti'l.r
•• A. Sur«., U!!'PmJ
I!
......
~
STATEN ISLAN~NEW YORK
OFFICE 01' DlREC'TOIt
VEIIEII£AI. DISEASE RESfARCH LQDIIATOIIY
UO 5.1WtI1IE HOSPITAL
SeptemDer 12, 1946
S.A.SUrseon John
o.
Cutler
Pan Aaerioua
10 Calle oriente
No.1 Guateaala Cit,. GQateaala
Dear Dootor
~utler:
We haTe 1011r letters ot the 3rd and 9th in regard to the
progesa being aade wi th the laborator1 and w1 th the prosr_ in
Guteaala.
M reaarcl. equipaent. proTision haa probab17 been aad. tor
IIOst ot the ••sentiala but the JUltter ot trauportation baa beea oonaiderabl, ooaplioated b, the truokina aDd. urit1ae .trike. in No
York. Mr. Pyre could not &1 Te WI any id. . . . to w.n the .q\lipact
whioh haa be8A useabled her• . . , ~ torward. I _ wiriD6 you toclq
in the aatter ot borl'Ow1D6 equipa8At tro. the Arrq. W. haTe not hat
.uoh luck in that respeot in New York. You JUl1 8AOOunt.. a aore
taTDrabl• • ituation d01lll there. BID1renr. ~e lut ah1}aent oontained
ao .any easential i t_s that 1 rather doubt the MTi.abili 10,. ot and.a"fOriD8 to .eoura allot th_ on a loan bui. tro. the u..,.
o
We will set the FOB to ,.CMl ae rapicU, .a possible. we are
cheok1D6 into the aatter ot air ~re... It is go1D6 to bll a rath.r
up. .i Te way ot tftJl.8port1Da aaMrials was. the, are Ti tally •••• nt1&1. lie probab17 will be able to .8Ild so.e P08 with Kisa .alker
and with Doctor Harlow when the1 lecT••
lJ:L regard. to .BAl.. this ch_ioal is not aTaUabl. ~er
oiell, but w. t.al sure that Dootor Eagl. will haT. a auppl1 upon
which .e
draw. W. w111 ... hill at a ...tina toaorrow aDd will
ask. the neo •••
arftD&eIlct ••
a.,. ar,
We will add a t,yp_riter to the tinal shipa8llt in .vent
ot our b.ing able to obtain 0118. W. haTe ha4 .e"f8raJ. on order tor
a 10DS period ot t1aa but •• appear to be ••ldng oD17 11a1.ted prosres. toward their deliver,.
We hope that both yourselt and IIrs. Outler are .nJo,iD8
Guat...u.a and will oontinue to do so when the work reall, ,.ta under wa,. We are looktas torward to a Tisi 10 ot in.peotion but no
de~inite date can be ..10 at the aoa_t.
With kindest resarda to all.
Sincerel,.
J.~'"I\I
.d~~otor.
J"F),{:tcw
7
mPBS
-.
OFFICE OF DlRICTOII
vomtEA1. DISEASE R£SEARCH LAIOItATOIIY
U. S. MARl" H05Pn'AL
August 28, 1940
Doctor John C. Cutler,
Senior Assistant Surgeon, USPHS
care
Oticina Sanitaria ~ Americana
10 Calle oriente No.1
GuBtemala City, Guatenlala
Dnar DoctorCutler:
l»ctor Arnold has just handed to he Forms 6569, Power.o-f'.
Attorney properly signed by you, but you tailed to state
just who this was to be make in tavor ot, I am ot the
opinion tb."\t you wish it tc the Irving Trust Company
but you had better advise aetore smae 1.101
~C~o[1!1)li8hed.
We all received the "Thank you" card 9nd ot course it
was appreciated.
Everything getting along tine t
am
hope to go on vacation
on October.
Balance ot shipment tor your station should move out sometime
in September.
Regards to you, 1;rs. Cut.ler and Doctor spoto.
YOurs very truly
~~~ ..-
C. H. Morrison, Admin. ASst.

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