neoTONE - BlackOrchid

neoTONE
Attack depigmentation serum
HYDROQUINONE FREE - KOJIC ACID FREE
neoTONE
Pigmentation disorders
ATTACK DEPIGMENTATION SERUM
Night care
Thanks to its combined formula of 6 synergic active ingredients, neoTONE stops the
overproduction of melanin and eliminates efficiently the pigmentation spots already
present in the skin.
Turn Over
Salicylic acid /
Glycolic acid
+
In epiderm under keratinocytes
Migration
TREATING THE PRE-FORMED
MELANIN
GLYCOLIC ACID
ASCORBIC ACID
SALICYLIC ACID
–
Licorice
6%
2%
0,1%
Melanin
In epidermic junction
–
Dopaquinone
PREVENTING THE APPEARANCE
OF MELANIN
LUMISKIN™
ALPHA ARBUTIN
LICORICE
L-Dopa
Cu++
4%
2%
0,1%
α MSH
α MSH Receptor
Cu++
–
Licorice / Alpha-Arbutin
L-Tyrosine
Active
tyrosinase
–
PK A
–
–
Ascorbic acid
PK C Ca++
LUMISKIN™
(Diacetyl Boldine)
Inactive
tyrosinase
neoTONE acts on the 3 stages of the melanin formation:
1. Before the melanin formation:
4% Lumiskin™ (Diacetyl boldin) blokes the α-adrenergic receptors and limits the Calcium
flow allowing the tyrosinase to remain inactive.
2. During the melanogenesis:
0.1% Licorice
act on the activated tyrosinase to inhibit its activity
2% α-arbutin
2% Ascorbic acid: inhibits tyrosinase and fights against free radicals
3. On existing brown spots:
6% Glycolic Acid: tyrosinase inhibition, preformed melanin reduction, anti-radical properties
0.1% Salicylic Acid: exfoliates through the reduction of corneocytes cohesion
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neoTONE acts on all the stages of the melanogenesis process thanks to its
6 active ingredients working synergistically.
neoTONE
Pigmentation disorders
ATTACK DEPIGMENTATION SERUM
Night care
Patient 1, multiple previous depigmentation treatments
D0
D30
-58% MLQI
D0
D30
Patient 2, all previous treatments ineffective
(Melasma Life Quality Index)
D0 = Severe - Markedly darker than surrounding
normal skin (L3)
D30 = Mild - Slightly darker than surrounding
normal skin (L1)
D0
D0
D30
D30
Protocol: neoTONE every evening on the area of melasma combined with
UVEBLOCK 50+ Invisible in the morning - 30 days - 24 patients - 2009 University Toulouse Hospital (France) - American Beirut Hospital (Lebanon)
CLINICALLY PROVEN EFFICACY IN DOUBLE BLIND PLACEBO TEST
After only 30 days of treatment
results are already visible.
neoTONE
THE NEW TREND ON
MELASMA MANAGEMENT
N
EW
neoTONE
Pigmentation disorders
ATTACK DEPIGMENTATION SERUM
Night care
■ Dosage
Apply neoTONE attack depigmenting serum every night on hyperpigmented
areas and to all the face for a homogeneous efficacy.
Results are quickly visible depending on the intensity of the pigmentation spots.
■ Results:
• Improvement in recalcitrant and severe melasma
• Early effective at day 30 for a whitening cream
• Patient asking for maintenance (out of protocol)
• No discoloration on healthy area
• High tolerance
HYDROQUINONE FREE - KOJIC ACID FREE
AN EFFECTIVE AND SAFE FORMULA