View the full schedule - Genome Engineering 4.0 Workshop

Genome 4.0
Engineering
a practical workshop
May 6 & 7, 2016 Cambridge, MA
Broad Institute 415 Main St.
Friday
8:30 - 9:00 Registration & light breakfast
9:00 - 9:05 Welcome • Winston Yan, Zhang Lab at Broad Institute & MIT
9:05 - 9:35 Keynote • Sylvain Moineau, Université Laval
CRISPR-Cas systems: from humble beginnings to today’s headlines
Session 1: Endless forms most beautiful: New Cas enzymes
9:40 - 10:00 Rodolphe Barrangou, North Carolina State University
Diversity of CRISPR-Cas systems and molecular machines
10:05 - 10:25 Eugene Koonin, NCBI
Discovery of novel CRISPR-Cas systems & new functions of Cas proteins by genome & metagenome mining
10:30 - 10:45 Omar Abudayyeh, Zhang Lab at Broad Institute & MIT
Functional characterization of novel Class 2 CRISPR-Cas systems
Coffee
11:10 - 11:40 Jim Collins, MIT
Synthetic gene networks - a bottom-up approach to genome engineering
Session 2: Next generation genome editing tools
11:45 - 12:00 Isaac Hilton, Gersbach Lab at Duke University
Controlling cellular transcription with epigenome engineering
12:05 - 12:20 Bernd Zetsche, Zhang Lab at Broad Institute & MIT
Genome engineering with CRISPR-Cpf1
12:25 - 12:40 Alexis Komor, Liu Lab at Harvard
A new approach to genome editing
Lunch & roundtable discussions of CRISPR basics & screening
1:45 - 2:15 Dan Voytas, University of Minnesota
The genome engineering revolution and plant agriculture
Session 3: Genome editing in model organisms
2:20 - 2:35 Wenning Qin, Biogen
Leveraging into microhomology mediated repair to generate CRISPR/Cas9 mice
2:40 - 2:55 Donald Bryant, Whited Lab at Harvard
Gene targeting in the unsequenced Mexican salamander
3:00 - 3:15 Melissa Harrison, University of Wisconsin
The CRISPR toolbox in flies
Coffee
Session 4: CRISPR-Cas mediated screens
3:40 - 4:00 Chris Vakoc, Cold Spring Harbor Laboratory
Exploiting the allele heterogeneity of CRISPR-Cas9-mediated mutagenesis
4:05 - 4:20 Neville Sanjana, New York Genome Center & NYU
Genetic screens using CRISPR libraries
4:25 - 4:45 Richard Sherwood, Brigham and Women’s Hospital
CRISPR screening of the regulatory genome
“Meet the Editor” & Happy Hour
Enjoy refreshments, meet colleagues & and get your questions answered by people
with hands-on expertise spanning all aspects of genome engineering
Genome 4.0
Engineering
a practical workshop
May 6 & 7, 2016 Cambridge, MA
Broad Institute 415 Main St.
Saturday
8:30 - 9:00 Light breakfast
9:00 - 9:25 Feng Zhang, Broad Institute & MIT
Genome editing using CRISPR-Cas systems
Session 5: Toward therapeutics
9:30 - 9:50 Connie Cepko, Harvard
Conditionally-stable nanobodies for detection and manipulation of biological activities
9:55 - 10:10 Dan Wang, Gao Lab at UMass Medical School
Applications of rAAV vectors in realizing in vivo genome editing
10:15 - 10:30 Leonela Amoasii, Olson Lab at UT Southwestern
Muscle and heart restoration by genome editing in a mouse model of muscular dystrophy
Coffee
Session 6: Homologous recombination
11:00 - 11:20 Jim Haber, Brandeis University
Improving gene editing: lessons from site-specific endonulceases in budding yeast
11:25 - 11:45 Jacob Corn, Innovative Genomics Institute & UC Berkeley
Molecular mechanisms to boost gene editing
11:50 - 12:10 Dan Durocher, University of Toronto
How to activate gene-targeting in G1 cells
Lunch & roundtable discussions of non-nuclease applications & delivery
1 : 1 5 - 1:45 Ethan Bier, UC San Diego
The implications of active genetics
Session 7: Specificity
1:50 - 2:05 Nicola Crosetto, Karolinska Institute
Genome-wide DNA double-strand break sequencing by BLESS/BLISS methods
2:10 - 2:25 Shiran Abadi, Mayrose Lab at Tel Aviv University
A computational algorithm for estimating cleavage specificity of the CRISPR-Cas9 System
2:30- 2:45 Vikram Pattanayak, Joung Lab at Harvard & MGH
Towards an engineered Cas9 without off-target effects
2:50 - 3:05 Ian Slaymaker, Zhang Lab at Broad Institute & MIT
Structure-guided engineering of Cas9 specificity
Coffee
Session 8: New applications
3:30 - 3:45 Gene Yeo, UC San Diego
Tracking RNA localization with RCas9
3:50 - 4:05 Dan Bauer, Harvard
Screening the non-coding genome
4:10 - 4:25 Hanhui Ma, Pederson Lab at UMass Medical School
•
CRISPRainbow: Interrogation
of chromosome dynamics in living cells
Poster Session & Happy Hour
6:30 - late Informal group dinner & drinks
Sponsored by the Broad Institute & BioMed Ventures
with Special Thanks to Addgene, Desktop Genetics, Benchling & Life Sciences