Staff meetings of the Mayo clinic

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February 2, 1949
:ral pattern is
ily disccrnible.
:mal-appearing
of early ana-
noderate pleomatisnr of the
rral pattern is
tbout one half
:ytes. The ren of the cytoN{itotic figures
;h-porver fielcl
gnancy
r!cc-yeaf
urvival
rate,
Er cent
79.3
28.6
1
l.l
9.1
eæ figures represeni
rumber
of the
:tural patterns
ole presents a
ce of marked
hromatism of
rr 5 per highrich operation
rger than one
Lvailable rvere
a.lignancy rvas
rerative duractors, such as
', were applic-
rle operations
ittle effect on
Fcl-rruary 2, 1949
STAFF ITEETINGS OF THE MAYO CLINIC
a
i1
SUIITMAI{Y AND CONCLUSIONS
study of irilracranial epenclymomas, a method of gracri'g
.l'ras.flInonthis
rhe concept of anaprasia àr aedimere"ii"ti"r,'."ùJ, inon
on
the.-concept of histogenesis_, is presented. c.it"riu-ioi
i"",
!àa",
malignancy have been delineaied. Grade
-"rij."r.y iu, n".n"i
correlated *'ith postoperative.survival period;
"rthe
reïuits-'suifort our
original concept. we have discarded ihe t"rm ,,ependymoËlastoma"
from our classification of gliomas, inasmuch as the;.t;rJ;;racring
ependymomas rvhich has been presented herein i, ; ;;;""àËnoi,iu"
index of malignancy.
A SI]IPLIFIED CLASSIFICATIOI{ OF THE GLIO]IAS
James W. Kernohan, trI.D., M.A. in_Anatomy and pathology,
Section on Pathologic
Robert f. iU"Uoi, li.n,-l,f .S. i"
Neurosurgery. Fellow .Ana_tomy,
Neurôiurgery,
ÀIay" È""ria"ll*,' Hendrik
.in
J. Svien, lI.D., M.S. in_surgery
uia-Âttr.a W- Àà.",\ M.D., trLS.
in Surgery, Section on Neuro-iogic surgery: The classificatio' of the
glioma.- group of brain tumorJ uy B"aiÉy
r..n
generally accepted by neuropath-ôlogists, neurologists
"rJ c".ll"gl"tu.
and neurosurgeons- Little has been added to theii outstanà'ing coniribution.
on the other hand, generar pathorogists have not ;"k; tJ'tinaty ,o
the nomenclarure introduced by Bai-iley ur.t curr,i"g,;;à";";
simpri_
fication of this might be wercomed by-pathorogists is *n"iJ.
The current concept of the diffeient types of brain
"
tumors is
based on the assun.red resembrance of the uiriou. ..ri, in giio-as
to
embrvonic cells in the differentiarion of the developir;;";;J;'rysrem.
This approach to the crassificarion of the griomas h; b;";;riticizeci
b.r .1eu1o-e.mbryologists and neuro-anatomiits because oi-iir"-ru.r.
or
similarity berrveen the celrs in most of the ,.ii.àrù""nî gtio,ou=
and any cell in the developing embryo. In ,eceni y"'uË-on"
oi u,
(J-w.K.) has been accustomed to thin[ and teach trr"i tr,.
."iis
in the
mos.t rapidly growing glio-mas represent different phases
o] a.àiri"r.n_
tiation rather than undifferenfiâtion. rnu.,
o, u
glioblastoma multiforme simply represents various
"rr'urt.Joiu.à-riu
d;g;;;;i-àediffer_
entiation of astrocytes.
An increasing number of path-ologists feel that astrocytoma,
astro_
blastoma and glioblastoma murtiforrie represent differenr
degrees of
malignancy of the same type of neoplasm. we have iounJui
int"._
mingling of astrocytes with more anaplastic astrocyt". ln-uri.obrastomas and rve have noted compretery anaprastic tr.à. l"rrrin trre
''
oiliial..ï;'"J"ilu-1:n*:i%#,'.mu
1926, 175 pp.
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