LEIPZIG, 03rd – 04th NOVEMBER 2016

PRELIMINARY PROGRAM
LEIPZIG, 03rd – 04th NOVEMBER 2016
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Introduction
INTRODUCTION
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Second international Symposium adressing HPVinfection in
Head and Neck Cancer on behalf of the European Head and
Neck Society (EHNS), with scientific support of the German
Society of Otolaryngology Head and Neck Surgery (DGHNO
KHT), Interdisciplinary Working Group Head & Neck tumors of
German Cancer Society (IAG KHT of DKG), Dutch Head and
Neck Society, Polish Study Group of Head & Neck Cancer.
We are looking forward to welcoming you in
November 2016 in Leipzig.
SCIENTIFIC
ORGANIZING
COMMITTEE
Prof. Dr. Andreas Dietz
Prof. Dr. C. René Leemans
Chairman, Clinic of Otolaryngology, Professor and Chair
Head and Neck Surgery and
Department of Otolaryngology/
Department of Head Medicine and Head & Neck Surgery
Oral Health, University of Leipzig
VU University Medical Center
Amsterdam
Prof. Dr. Wojciech Golusinski
Prof. Dr. Jens Peter Klußmann
Director of Head and Neck Service, Chairman, Clinic of Otolaryngology,
Greater Poland Cancer Center, Head and Neck Surgery,
Poznan
University of Gießen
Preface
PREFACE
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Ladies and Gentlemen,
Dear medical doctors and scientists,
It is my great pleasure to welcome you all in Leipzig for the Second International Symposium addressing HPV infection in Head
and Neck Cancer on behalf of the European Head and Neck
Society (EHNS). We feel very honoured that you chose our city
for your European conference and hope that you will spend a
pleasant and impressive time in Leipzig. As mayor of this fast growing, young and shining city and host of the city hall, your conference place, I would like to give you a brief introduction to the
interesting history of this building. Owing to Leipzig’s increasing
importance both politically and administratively, our administration was in need of a new and more spacious infrastructure. The
architect and city building director of Leipzig, Hugo Licht, was
charged with the design of the new city hall. Inaugurated in 1905,
the city hall is often considered as one of the most important city
halls in Germany and is particularly well known for its historicist
style and ornamental façade. Today, this building is definitely in
the heart of Leipzig and will be an ideal accommodation for your
Mayor City of Leipzig
conference. Regarding your topic and recognizing the severity
Burkhard Jung
and complexity of head and neck cancer, I would like to emphasize the success the ENT department and Cancer Centre (UCCL)
of our University has achieved in attracting patients, students, doctors and scientists nationwide thanks to their well-recognized strong
fight against head and neck cancer. It is interesting to learn that
HPV infection plays an increasing role in development of this type
of cancer. Therefore I can understand that questions like vaccination beside life style conditions have to be proven for future prevention strategies. This is why I am especially grateful for this important stimulus you are providing Leipzig, a city which has recently
experienced a strong growth in scientific and educational structures. I would like once again to extend to you all my gratitude
for your participation and my wishes for particularly fruitful hours
of lectures and debates. I am looking forward to welcoming you
in Leipzig again soon and I hope that we will be successful in captivating you with our city’s charming and international atmosphere.
We corsially welcome you in November,
sincerely yours, Burkhard Jung, Mayor City of Leipzig
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Recommended an Endorsed – Head and Organisation
Venue
RECOMMENDED AND
Contact
ENDORSED BY
Mrs. Romy Wyrwas
Secretary Division of Otolaryngology, Head and Neck Surgery
romy.wyrwas@uniklinik-leipzig.de
Fon: +49 (0) 341 9721700
European Head and Neck Society
Fax: +49 (0) 341 9721709
Nederlandse Werkgroep
Hoofd-Hals Tumoren
Mrs. Julia Leupold
Eventmanagement
veranstaltungsmanagement@uniklinik-leipzig.de
For more detailed information please see:
Deutsche Gesellschaft für Krebsmedizin
http://hno.uniklinikum-leipzig.de/hnocms.site,postext,
Arbeitsgemeinschaft Onkologie
der deutschen Gesellschaft
für Hals-Nasen-Ohrenheilkunde,
Kopf- und Halschirurgie
kursefortbildungsangebote.html
VENUE
Neues Rathaus
Martin-Luther-Ring 4 – 6
04109 Leipzig
Polish Study Group of
Head and Neck Cancer
HEAD AND
Head
ORGANISATION
Prof. Dr. Andreas Dietz
Prof. Dr. C. René Leemans
Prof. Dr. Wojciech Golusinski
Prof. Dr. Jens Peter Klußmann
Organisation
Prof. Dr. Susanne Wiegand, Dr. Gunnar Wichmann
INSTRUCTIONS
Public transport by tram; bus; city train (stations):
University of Leipzig Hospitals and Clinics
FOR ARRIVAL
Tram number 2, 8, 9 to “Neues Rathaus”
Department of Head Medicine and Dentistry
Division of Otolaryngology, Head and Neck Surgery
Tram number 10, 11 to “Wilhelm-Leuschner-Platz“
Bus number 89 to “Neues Rathaus“
City train (S-Bahn) number S1-S5X to “Wilhelm-Leuschner-Platz”
Director Prof. Dr. Andreas Dietz
Liebigstraße 12
If you arrive by car:
04103 Leipzig
Limited underground parking with costs at
Petersbogen with access road Lotterstraße
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Registration – Recommendations – Hotels
REGISTRATION
• Regular registration fee
Invited Speakers
Seaside Park Hotel Leipzig****
250,00 Euro
• Early Bird
(until 30/06/2016)
• Evening event on 03/11/2016
9
Richard-Wagner-Straße 7, 04109 Leipzig,
150,00 Euro
Fon: +49 (0) 341 98 52 0
50,00 Euro
reservierung@parkhotelleipzig.de
http://www.parkhotelleipzig.de/
Single room: 95,00 Euro (Including breakfast)
Double room: 115,00 Euro (Including breakfast)
Please register online at:
http://www.ukl.vcongress.de/hpv2016
ACCOMMODATION
ABSTRACT
Send your abstract until 15/09/2016 at
For the conference participants contingents of rooms with
romy.wyrwas@uniklinik-leipzig.de.
special rates have been reserved in different hotels in Leipzig.
Please use the form on the homepage:
Please use the keyword “HPV Congress”.
http://hno.uniklinikum-leipzig.de/hnocms.site,postext,
kursefortbildungsangebote.html
HOTELS
Hotel Michaelis Leipzig***
Paul-Gruner-Straße 44, 04107 Leipzig, Fon: +49 (0) 341 26 78 0
info@michaelis-leipzig.de
INVITED SPEAKERS
http://www.michaelis-leipzig.de/
Single room: 69,00 Euro
• Dr. Athanassios Argiris, Athens, Greece
• Prof. Philippe Lambin, Maastricht, Netherlands
Double room: 79,00 Euro
• Prof. Thomas Blankenstein, Berlin, Germany
• Prof. Stephan Lang, Essen, Germany
Including breakfast
• Dr. Ruud Brakenhoff, Amsterdam, Netherlands • Prof. C. René Leemans, Amsterdam, Netherlands
• Prof. Andreas Dietz, Leipzig, Germany
• Prof. Markus Löffler, Leipzig, Germany
• Prof. Rainer Fietkau, Erlangen, Germany
• Prof. Andrzej Marszalek, Poznan, Poland
Motel One Leipzig-Augustusplatz***
• Prof. Stefan Gattenlöhner, Gießen, Germany
• Prof. Hisham Mehanna, Birmingham, UK
Ritterstraße 4, 04109 Leipzig, Fon: +49 (0) 341 25 27 98 0
• Prof. Maura L. Gillison, Columbus, USA
• Dr. Amanda Psyrri, Athens, Greece
leipzig-augustusplatz@motel-one.com
• Dr. Pawel Golusinski, Poznan, Poland
• Dr. Miriam Reuschenbach, Heidelberg, Germany
http://www.motel-one.com/de/hotels/leipzig/
• Prof. Wojciech Golusinski, Poznan, Poland
• Dr. Tanguy Seiwert, Chicago, USA
Single room: 78,50 Euro
• Prof. Cai Grau, Aarhus, Denmark
• Prof. Christian Simon, Lousanne, France
Double room: 98,00 Euro
• Prof. Vincent Gregoire, Brussels, Belgium
• Dr. Ernest Jan Speel, Maastricht, Netherlands
Breakfast: 9,50 Euro
• Prof. Neil Hayes, Chapel Hill, USA
• Prof. Erich Madison Sturgis, Houston, Texas / USA
• Dr. Jochen Hess, Heidelberg, Germany
• Prof. Dr. Dietmar Thurnher, Graz, Austria
• Dr. Mathias Hofer, Leipzig, Germany
• Dr. Ingeborg Tinhofer-Keilholz, Berlin, Germany
Motel One Leipzig-Nikolaikirche***
• Prof. Thomas Hoffmann, Ulm, Germany
• Dr. Silke Tribius, Hamburg, Germany
Nikolaistraße 23, 04109 Leipzig, Fon: +49 (0) 341 33743 70
• Dr. Dana Holzinger, Heidelberg, Germany
• Prof. Agnieszka Trojanowska, Poznan, Poland
leipzig-nikolaikirche@motel-one.com
• Prof. Sefik Hosal, Ankara, Turkey
• Prof. Jan B. Vermorken, Edegem, Belgium
http://www.motel-one.com/de/hotels/leipzig/
• Prof. Terry Jones, Liverpool, UK
• Dr. Steffen Wagner, Gießen, Germany
Single room: 69,00 Euro
• Prof. Ulrich Keilholz, Berlin, Germany
• Dr. Gunnar Wichmann, Leipzig, Germany
Double room: 79,00 Euro
• Prof. Jan Klozar, Prague, Czech Republic
• Prof. Susanne Wiegand, Marburg, Germany
Breakfast: 9,50 Euro
• Prof. Jens Peter Klußmann, Gießen, Germany
• Dr. Stefan M. Willems, Utrecht, Netherlands
• Dr. Maren Knödler, Leipzig, Germany
• Prof. Barbara Wollenberg, Lübeck, Germany
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Hier steht der Kolumnentitel
Program
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03rd NOVEMBER 2016 THURSDAY
08:30
Welcome Address
Andreas Dietz, C. René Leemans, Peter Klußmann,
Wojciech Golusinski
08:40
Welcome Address
Burkhard Jung, Mayor City of Leipzig
08:50
Welcome Adress
Michael Stumvoll, Dean of Medical Faculty University of Leipzig
09:00
Epidemiology and molecular biology
Chair: Maura L. Gillison, C. René Leemans
Update incidence HPV associated Oropharynx
carcinoma worldwide / Pawel Golusinski / 15´
Clinical relevant new insights HPV related cell
cycle changes / Jan Klozar / 15´
Diagnostic accuracy of p16 and HPV serology in
predicting true HPV involvement / Dana Holzinger / 15´
Viral load, gene expression and mapping of viral
integration / Ernest Jan Speel / 15´
Cancer Genome Atlas Network Head & Neck / 10:00
Neil Hayes / 20´
HPV-mediated Carcinogenesis / Ruud Brakenhoff / 20´
HPV related Prognostic profiling in HNSCC;
LIFE Consortium / Gunnar Wichmann / 20´
11:00 – 11:30 Coffee Break
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Program
Program
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11:30
Free papers
15:00
Recurrent metastatic HPV positive HNSCC
Chair: Wojciech Golusinski, Vincent Gregoire
Chair: Amanda Psyrri, Ulrich Keilholz
12:00
Clinical implications of HPV
Patient selection and management differs according to HPV /
Chair: Wojciech Golusinski, Vincent Gregoire
Hisham Mehanna / 20´
HPV related clinical implications in decision making /
Impact of HPV on first and second line treatment / Maura L. Gillison / 20´
Jan B. Vermorken / 20´
Impact of HPV on immune checkpoint inhibition /
Validation of HPV-based prognostic risk models / Markus Löffler / 20´
Tanguy Seiwert / 20´
Clinical relevance of HPV related signatures (Genom, Methylom) / Jochen Hess / 20´
16:00 – 16:30 Coffee Break
13:00 – 14:00 Lunch
16:30
Free papers
Lunch Symposium by Karl Storz Company
Chair: Cai Grau, Stefan M. Willems
Precission surgery and integrated operation room of the future
Chair: Mathias Hofer, Susanne Wiegand
17:00
Debate
Chair: Andreas Dietz, Agnieszka Trojanowska
Transoral Mikro Laser Surgery (TLM) of Oropharyngeal
Cancer / Susanne Wiegand / 35´
Statement: This house believes that HPV positive oropharyngeal
Image 1 SPIES / Mathias Hofer / 25´
cancer is highly radiosensitive and therefore primary surgery is not
the primary choice of treatment.
For the motion: Vincent Gregoire, Cai Grau
Against the motion: Terry Jones, Dietmar Thurnher
14:00
Surgery and HPV in HNSCC
Chair: Peter Klußmann, Barbara Wollenberg
Does HPV change the need of surgical radicality –
pathological view? / Andrzej Marszalek / 15´
HPV-based risk model in surgically treated patients / Peter Klußmann / 15´
TORS and HPV: Current lessons in daily routine / Christian Simon / 15´
The role of salvage surgery in HPV positive and
negative patients / Sefik Hosal / 15´
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Program
Program
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09:00
Prognostic impact of HPV in HNSCC
19:00 Working Dinner
Chair: Maura Gillison, Ruud Brakenhoff
Bayerischer Bahnhof
Pedictive value of Radiomics in HNSCC,
Lecture EHNS outlook and future aspects
the MAASTRO experience / Philippe Lambin / 15´
President C. René Leemans
20:00
20:30Presentation of the three best posters and ceremony
of the EHNS-Poster Award
Hypoxie related imaging and HPV related HNSCC /
Agnieszka Trojanowska / 15´
Organizing a translational research program in HPV-related
malignancies: The MD Anderson HPV Moon Shot /
Erich Madison Sturgis / 15´
Value of HPV in CUP HNSCC / Athanassios Argiris / 15´
10:00
Round table
Clinical questions for the pathologist regarding HPV in HNSCC
Moderation: Erich Madison Sturgis
Participants: Barbara Wollenberg, Andrzej Marszalek, Stefan Gatten
löhner, Stefan M. Willems, Ulrich Keilholz, Vincent G
­ regoire
11:00
Free papers
Chair: Susanne Wiegand, Jochen Hess
04th NOVEMBER 2016 FRIDAY
12:00
HPV changing practise in radiation oncology of HNSCC
Chair: Rainer Fietkau, Terry Jones
08:00 – 09:00 Breakfast
Delineation of constrictors in HPV positive oropharyngeal
HNSCC / Vincent Gregoire / 15´
Reducing adjuvant radiation dose after R0-resection in
HPV-HNSCC / Rainer Fietkau / 15´
ECS makes a difference in HPV+HNSCC regarding
adjuvant treatment? / Silke Tribius / 15´
Breakfast Symposium
Immunocheckpoint Inhibition in HNSCC
Chair: Andreas Dietz, Wojciech Golusinski
Rising clinical aspects in immune therapy of HNSCC /
Thomas Hoffmann / 30´
Possible future aspects of immune check point inhibition
Assessing treatment of the N0-Neck in context HPV / in HNSCC / Tanguy Seiwert / 30´
Hisham Mehanna / 15´
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Program
Program
13:00 – 14:00 Lunch Break
17:00
Burning future topics
Chair: Jan Klozar, Miriam Reuschenbach
Lunch Symposium by Merck Serono
Implication and suggestions of liquid biopsy in
context of HPV-HNSCC / Ingeborg Tinhofer-Keilholz / 20´
New developments in TORS / Stephan Lang / 20´
Future answers from Pathology for improvement of
decision making / Stefan Gattenlöhner / 20´
EGFR targeting in HPV pos. oropharyngeal HNSCC
Chair: C. René Leemans, Peter Klußmann
Future directions in induction chemotherapy /
Athanassios Argiris / 20´
Efficacy of Cetuximab due to EGFR-Inhibition and / or ADCC? /
Ulrich Keilholz / 20´
Patient gray zones for less toxic alternatives to cisplatin /
Maren Knödler / 20´
14:00
Vaccination
Chair: Thomas Blankenstein, Cai Grau
Adoptive T-cell transfer targeting HPV16 E6 peptides /
Thomas Blankenstein / 20´
Vaccine for treatment of HNSCC overexpressing p16 /
Miriam Reuschenbach / 15´
Ongoing / planned trials addressing vaccination against HPV /
Amanda Psyrri / 15´
The role of NK-cell infiltration in oropharyngeal cancer /
Steffen Wagner / 15´
15:10
Interdisciplinary Tumorboard
Moderation: Andreas Dietz
Participants: Stephan Lang, Vincent Gregoire, C. René Leemans,
Wojciech Golusinski, Ulrich Keilholz, Andrzej Marszalek,
Stefan Gattenlöhner
16:00
Free papers
Chair: Athanassios Argiris, Dietmar Thurnher
16:30 – 17:00 Coffee Break
18:00
Closing remarks
Andreas Dietz, C. René Leemans, Peter Klußmann,
Wojciech Golusinski
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Sponsors
SPONSORS
advertisement / Anzeige
The implementation of this training course would not be possible
without the financial contribution. Their help is highly appreciated.
Kindly supported by:
(14.500 EUR)
Andreas Fahl Medizintechnik GmbH
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PUBLISHING INFORMATION
Publisher:
University of Leipzig Hospitals and Clinics
Department of Head Medicine and Dentistry
Division of Otolaryngology, Head and
Neck Surgery
Photos:
Benjamin Glombig
Michael Bader (Coverphoto)
Designed by:
Metronom | Agentur für Kommunikation
und Design GmbH, Leipzig
Revised:
January 2016
www.uniklinikum-leipzig.de