SYMBIOS® Biphasic Bone Graft Material SYMBIOS® Collagen

Regenerative Solutions:
SYMBIOS® Biphasic Bone Graft Material
SYMBIOS® Collagen Membrane SR
NEW
Scanning electron micrograph (SEM): Longitudinal section of phycogenic
biphasic 20% HA/80% ß-TCP granule (x 5000)
Scanning electron micrograph (SEM): Cross section of phycogenic biphasic
20% HA/80% ß-TCP granule (x 6000)
SYMBIOS® Biphasic Bone Graft Material
SYMBIOS Biphasic Bone Graft Material (BGM) is a resorbable
inorganic bone forming material in granular form of plant
origin derived from red marine algae. The chemical composition
of this interconnected porous biological product is similar
to the inorganic part of the human bone. SYMBIOS Biphasic
BGM is a composition of 20% hydro­xyapatite (HA) and
80% β
­ -tricalciumphosphate (ß-TCP). Due to the high tricalciumphosphate content of the product it resorbs significantly faster
than pure hydroxyapatite.The biphasic BGM is biocompatible
and osteoconductive. It can be used for indications such as
treatment/filling of periodontal or peri-implant defects, extraction
sockets and for sinus elevation grafting. For optimal tissue
regeneration the defect should be covered by a membrane.
The selection of the two grain sizes is dependent on the defect.
Recommended grain size:
• Grain size 0.2 mm to 1.0 mm, e.g. augmentation
of small defects
• Grain size 1.0 mm to 2.0 mm, e.g. augmentation
of lateral defects and sinus floor elevation
• Osteoconductive
Bone analogous properties and interconnecting pores
• Resorption kinetics in the sense of restitutio ad integrum
Material degradation and bone remodeling/healing are
balanced. Resorbs almost completely
• Volume stability
The resorption properties enable volume stability during
bone formation
• Straightforward application
Saturation with patient’s blood and addition of autogenous
bone chips improve healing
Resorption kinetics in a pre-clinical animal study
Histomorphometric analysis
Bone Graft Material (100% HA)
SYMBIOS® Biphasic BGM (20/80% HA/β-TCP)
Amount of newly formed bone respectively remaining
Bone Graft Material (100% HA) in a specified augmented area
%
Amount of newly formed bone respectively remaining
Bone Graft Material (20/80% HA/β-TCP) in a specified augmented area
%
HA
Bone
50
40
30
30
20
20
10
10
4 8 Time [weeks]
Bone
50
40
2 HA/β-TCP
2 4 8 Time [weeks]
Percentage of newly formed bone in relation to remaining Bone Graft Material (BGM) 100% HA and biphasic BGM 20 / 80% HA / β-TCP respectively after
placement 2, 4 and 8 weeks in cortical / spongious defects in sheep. Data on file.
Scanning electron micrograph (SEM): Cross-section of SYMBIOS Collagen Membrane SR consisting of a collagen fiber matrix that is clearly visible (x 5000).
SYMBIOS® Collagen Membrane SR
SYMBIOS Collagen Membrane SR (slow resorbable) is a bioresorbable, implantable collagen type I originating from bovine Achilles tendon. It is intended for use in
­dental surgery procedures. The membrane functions as a barrier, aiding in wound
healing after dental surgery in cases with a dental implant, a bone defect or ridge
reconstruction. Fiber matrix construction allows tissue integration, while preventing
direct passage of bacteria and epithelial cells.
• Safe for the patient
Manufactured from highly purified collagen type I derived from bovine Achilles
tendon
• Prevents epithelial downgrowth
Cell occlusive
Pictures in actual size
30 x 40 mm
• You can suture or tack the membrane in place without tearing
Unique fiber orientation provides high tensile strength
• Stiff enough for easy placement, yet easily drapes over ridge
Optimized flexibility. Can be placed either dry or hydrated
20 x 30 mm
15 x 20 mm
Resorption kinetics
In vivo resorption rate of SYMBIOS® Collagen Membrane SR
Predictable
resorption time:
26 – 38 weeks
% of Membrane Remaining
100
80
Highly purified collagen type I derived
from bovine Achilles tendon
60
40
20
4
8
12
16
20
24
28
32
Resorption time after placement
SYMBIOS Collagen Membrane SR has a resorption time of 26 to 38 weeks. Data on file.
Time [weeks]
Order Numbers
SYMBIOS® Biphasic Bone Graft Material
SYMBIOS® Collagen Membrane SR
ORDER NO.
DESCRIPTION
ORDER NO.
DESCRIPTION
31 – 0110 0.2 – 1.0 mm, 0.5 ml
(for augmentation of small defects)
3290 5270 15 x 20 mm, 2 Membranes/box
3290 5271
20 x 30 mm, 2 Membranes/box
31 – 0111
0.2 – 1.0 mm, 1.0 ml
(for augmentation of small defects)
3290 5272
30 x 40 mm, 2 Membranes/box
31 – 0112
1.0 – 2.0 mm, 1.0 ml
(for augmentation of lateral defects and
sinus floor elevation)
31 – 0113
1.0 – 2.0 mm, 2.0 ml
(for augmentation of lateral defects and
sinus floor elevation)
Key references
SYMBIOS® Biphasic Bone Graft Material 1)
SYMBIOS® Collagen Membrane SR 2)
Schopper C, Ziya-Ghazvini F, Goriwoda W, et al. HA/
TCP compounding of a porous CaP biomaterial improves
bone formation and scaffold degradation – a long-term
histological study. J Biomed Mater Res B Appl Biomater
2005;74(1):458–67.
Behfarnia P, Khorasani MM, Birang R, Abbas FM.
Histological and histomorphometric analysis of animal
experimental dehiscence defect treated with three bio
absorbable GTR collagen membrane. Dent Res J (Isfahan)
2012;9(5):574–81.
Spassova E, Gintenreiter S, Halwax E, et al. Chemistry,
ultrastructure and porosity of monophasic and biphasic
bone forming materials derived from marine algae. Mat.wiss. u Werkstofftech. 2007;38(12):1– 8.
Guda T, Walker JA, Singleton BM, et al. Guided bone
regeneration in long-bone defects with a structural
hydroxyapatite graft and collagen membrane. Tissue Eng
Part A 2013;19(17–18):1879–88.
Zhou AJ, Clokie CM, Peel SA. Bone formation in algaederived and synthetic calcium phosphates with or without
poloxamer. J Craniofac Surg 2013;24(2):354 –9.
Tovar N, Jimbo R, Gangolli R, et al. Evaluation of bone
response to various anorganic bovine bone xenografts: an
experimental calvaria defect study. Int J Oral Maxillofac
Surg 2014;43(2):251–60.
Zhou AJ, Peel SA, Clokie CM. An evaluation of
hydroxyapatite and biphasic calcium phosphate in
combination with Pluronic F127 and BMP on bone repair. J
Craniofac Surg 2007;18(6):1264 – 75.
Schopper C, Moser D, Spassova E, et al. Bone
regeneration using a naturally grown HA/TCP carrier
loaded with rhBMP-2 is independent of barrier-membrane
effects. J Biomed Mater Res A 2008;85(4):954-63.
1)
SYMBIOS Biphasic Bone Graft Material is manufactured by AlgOss Biotechnologies GmbH
2)
SYMBIOS Collagen Membrane SR is manufactured by Collagen Matrix, Inc.
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