Institutul Naţional de Diabet, Nutriţie şi Boli Metabolice "Prof. N. C.

Transcription

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Institutul Naţional de Diabet, Nutriţie şi
Boli Metabolice "Prof. N. C. Paulescu"
Str. Ion Movilă Nr. 5-7
Bucureşti Sector 2
79811, România
Tel: +4021 210 6460
Fax: 4021 210 2295
E-mail: cit@paulescu.ro
RAPORT AUTOEVALUARE
INSTITUTUL DE DIABET, NUTRIŢIE
ŞI BOLI METABOLICE
„PROF. N.C.PAULESCU BUCUREŞTI”
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ANEXA 1 (la metodologie)
RAPORT DE AUTOEVALUARE
perioada 2002-2007
1. Datele de autentificare ale unităţii de cercetare-dezvoltare
1.1. Denumirea: Institutul Naţional de Diabet, Nutriţie şi Boli Metabolice „Prof. Dr. NC
Paulescu‖, Bucureşti
1.2. Statutul juridic*1): Institut Naţional
1.3. Actul de înfiinţare*2): Ordinul Ministerului Sănătăţii Nr. 285/15 III 1993
1.4. Numărul de înregistrare în Registrul potenţialilor contractori: 4204151
1.5. Director general/Director: Manager - Cj Robert Agafiţei
1.6. Adresa: Str. Ion Movilă Nr. 5-7, Sector 2, Bucureşti
1.7. Telefon, fax, pagina web, e-mail:
Tel – 210.64.60
Fax – 210.22.95
Web - www.institutuldiabetpaulescu.ro
2. Domeniul de specialitate
2.1. Conform clasificării UNESCO*3): 3206
2.2. Conform clasificării CAEN: 8511
3. Starea unităţii de cercetare-dezvoltare
3.1. Misiunea unităţii de cercetare-dezvoltare, direcţiile de cercetare, dezvoltare, inovare:
(maximum 1.000 de caractere):
În urmă cu aproximativ şase decenii a fost înfiinţat la Bucureşti de către Prof. Ion Pavel
un mic centru antidiabetic, printre primele din Europa. Din acesta s-a dezvoltat Clinica de
Diabet, Nutriţie şi Boli Metabolice de la Spitalul „Dr. Ion Cantacuzino‖, transformată în anul
1993 în Institutul de Diabet, Nutriţie şi Boli Metabolice „Prof. N.C. Paulescu‖. Acesta a fost
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ridicat în anul 2007 la statutul de Institut Naţional. Preocuparea esenţială a instituţiei este
asistenţa de specialitate a bolnavilor cu diabet zaharat şi/sau alte boli de metabolism şi nutriţie.
La aceasta se adaugă partea formativă (de învăţământ) pentru studenţi, rezidenţi, doctoranzi şi
alte categorii de tineri. În acelaşi timp, o componentă puternică a activităţii noastre a fost şi
rămâne cercetarea ştiinţifică şi publicarea de literatură ştiinţifică. Multe dintre studiile efectuate
în perioada 2002-2007 au fost incluse în proiecte şi/sau granturi naţionale sau internaţionale,
soldându-se cu rezultate interesante, ceea ce a permis o valorificare superioară a lor. Au fost
abordate teme legate de genetica diabetului şi a altor dezordini metabolice, teme privind
patogenia şi terapia diabetului, teme privind extensia obezităţii şi combaterea acestui fenomen,
etc. O parte dintre proiectele menţionate vor continua în intervalul următor, lor urmând a li se
adăuga noi teme şi preocupări. O altă cale majoră a muncii de cercetare o reprezintă trialurile
clinice, realizate în cooperare cu marile companii farmaceutice. Ele sunt cel mai adeseori
destinate testării eficienţei şi siguranţei unor noi produse medicamentoase, necesitând
respectarea cu stricteţe a unor reguli de execuţie şi interpretare. În momentul de faţă, activitatea
de cercetare a Institutului „Prof. Dr. N.C. Paulescu‖ trece printr-un profund proces de
reorganizare. Sperăm să preluăm ceea ce a fost bun în trecut şi să ne orientăm spre o cercetare
ştiinţifică de tip intesiv, condusă după principiile managementului modern.
3.2. Modul de valorificare a rezultatelor de cercetare, dezvoltare, inovare şi gradul de
recunoaştere a acestora (maximum 1.000 de caractere):
Valorificarea rezultatelor se face prin prezentări poster şi orale la congrese naţionale şi
internaţionale de profil, precum şi prin publicarea de articole originale in extenso în reviste
internaţionale de prestigiu (cotate ISI sau PubMed), precum şi în reviste naţionale, cotate ISI sau
CNCSIS B. La acestea s-au adăugat în perioada 2002-2007 şi se vor adăuga şi în viitor
monografiile cu caracter „de sinteză‖. Cercetătorii noştri au publicat în ţară şi în străinătate
lucrări de reală valoare în care, pe lângă datele culese din literatura internaţională, au fost incluse
rezultatele obţinute în Institutul „Prof. N.C. Paulescu‖. Astfel de monografii au marele avantaj de
a prezenta cititorilor din toată lumea probleme medicale de actualitate, la rezolvarea cărora
autorii români au adus contribuţii notabile.
3.3. Situaţia financiară - datorii la bugetul de stat: - Fără datorii la bugetul de stat
4. Criterii primare de performanţă
punctaj
4.1. Lucrări ştiinţifice/tehnice publicate în reviste de specialitate cotate ISI*4)
4.1.1. Număr de lucrări ştiinţifice
29
x 30
870 puncte
4.1.2. Punctaj cumulat ISI*5)
278.206
x5
1391.03 puncte
4.1.3. Număr de citări în reviste de specialitate cotate ISI*6)
155 citari
x5
775 puncte
4
(Lista lucrărilor şi citărilor, grupate pe ani, se ataşează ca anexa nr. 4.1)
Total punctaj cap. 4.1: 3036.03 puncte
4.2. Brevete de invenţie*7)
4.2.1. Număr de brevete
0
x 30
4.2.2. Număr de citări de brevete în sistemul ISI
0
x5
(Lista brevetelor şi citărilor, grupate pe ani, se ataşează ca anexa nr. 4.2)
Total punctaj cap. 4.2: 0 puncte
4.3. Produse şi tehnologii rezultate din activităţi de cercetare, bazate pe brevete, omologări sau
inovaţii proprii. Studii prospective şi tehnologice şi servicii rezultate din activitatea de cercetaredezvoltare, comandate de beneficiar
(Se indică contractul şi firma care utilizează produsul, serviciul şi tehnologia).
4.3.1. Număr de produse, tehnologii, studii, servicii
0
x 20
(Lista produselor, serviciilor şi tehnologiilor, grupate pe ani, se ataşează ca anexa nr. 4.3)
Total punctaj cap. 4: 3036.03 puncte
5. Criterii secundare de performanţă
5.1. Lucrări ştiinţifice (tehnice) publicate în reviste de specialitate*8) fără cotaţie ISI
5.1.1. Număr de lucrări
21
x5
105 puncte
(Lista lucrărilor grupate pe ani se ataşează ca anexa nr. 5.1)
5.2. Lucrări ştiinţifice prezentate la conferinţe internaţionale cu comitet de program
5.2.1. Număr de comunicări prezentate
117
x5
(Lista comunicărilor grupate pe ani se ataşează ca anexa nr. 5.2)
585 puncte
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5.3. Modele fizice, modele experimentale, modele funcţionale, prototipuri, normative,
proceduri, metodologii, reglementări şi planuri tehnice noi sau perfecţionate, realizate în cadrul
programelor naţionale sau comandate de beneficiar
5.3.1. Număr de modele, normative, proceduri etc.:
0
x5
(Lista modelelor, normativelor etc., grupate pe ani, se ataşează ca anexa nr. 5.3)
Total punctaj cap. 5: 690 puncte
6. Prestigiul profesional
6.1. Membri (incluzând statutul de recenzor) în colectivele de redacţie ale unor reviste (cotate
ISI sau incluse în baze de date internaţionale) sau în colective editoriale ale unor edituri
internaţionale recunoscute
Număr de prezenţe în perioada pentru care se face evaluarea:
Nr. crt. Nume
0
x 20
Titlul revistei/editurii
6.2. Membri în colectivele de redacţie ale revistelor recunoscute naţional (din categoria B în
clasificarea CNCSIS)
Număr de prezenţe:
1.
2.
3.
4.
5.
6.
6
Dan Mircea Cheţa
Constantin Ionescu-Tîrgovişte
Radu Lichiardopol
Radu Lichiardopol
Cristian Guja
x 10
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine
Jurnalul Român de Diabet, Nutritie si Boli Metab
Diabetes Care, Ediţia în limba Română
6.3. Premii internaţionale obţinute printr-un proces de selecţie
Număr de premii:
Nr. crt. Nume Premiul
0
x 20
Anul
6.4. Premii naţionale ale Academiei Române
Număr de premii:
Nr. crt. Nume Premiul
0
Anul
60 puncte
x 20
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6.5. Conducători de doctorat, membri ai unităţii de cercetare
Număr de conducători de doctorat:
1.
2.
2
x 10
20 puncte
Dan Mircea Cheţa
6.6. Număr de doctori în ştiinţă, membri ai unităţii de cercetare
Număr de doctori în ştiinţă:
12
x 10
120 puncte
Total punctaj cap. 6: 200 puncte
Total punctaj cap. 4+5+6: 3926.03 puncte
7. Venituri realizate prin contracte de cercetare în domeniul pentru care se face evaluarea (în
perioada pentru care se face evaluarea):
7.1. Numărul şi valoarea contractelor de cercetare internaţionale finanţate din fonduri
publice*9):
Proiect: Type 1 Diabetes Genetics Consortium
Sponsor: NIH, NIDDK, JDRF
Coordonator Internaţional: Wake Forest University, North Carolina, USA
Coordonator European: Steno Diabetes Center, Copenhaga
Coordonator Naţional: Dr. Cristian Guja din partea IDNBM ―NC Paulescu‖
7.2. Numărul şi valoarea contractelor de cercetare internaţionale finanţate din fonduri private:
7.3. Numărul şi valoarea contractelor de cercetare naţionale finanţate din fonduri publice*10):
Granturi Academia Română
1. IZOLAREA DE INSULE PANCREATICE
Proiect GAR85 (Academia română) Contract Nr 127/2003
Perioada – 2003
Director de Proiect - Prof. Constantin Ionecu-Tîrgovişte
Buget – 2200 RON
2. IZOLAREA DE INSULE PANCREATICE
Proiect GAR85 (Academia română) Contract Nr 120/2004
Perioada – 2004
Contractor titular „IDNMB N Paulescu‖
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Buget – 3500 RON
3. TRANSPLANTUL DE INSULE PANCREATICE. SURSE PANCREATICE ANIMALE – O NOUA
TERAPIE
Proiect GAR363 Grant al Academiei Române – Contract 112/2006
Perioada 2005-2006
Director de proiect- Prof. Dr. Constantin Ionescu-Tirgoviste
Buget – 6000 RON
4. EVALUAREA BUNĂSTĂRII PSIHOLOGICE, A RATEI STĂRILOR DEPRESIVE ŞI A
CALITĂŢII ÎNGRIJIRILOR LA PACIENŢII DIABETICI TIP 1 (INSULINODEPENDENT)‖
Proiect GAR1246 - Grant al Academiei Române – Contract 132/2006
Perioada 2006
Director de proiect - CPII Mariana Costea
Buget – 5.000 RON
5. INVESTIGAREA RELAŢIEI DINTRE POLIMORFISMELE GENEI VEGF ŞI NEUROPATIILE
PERIFERICE CU INCIDENŢĂ CRESCUTĂ LA COPII ŞI TINERI, UTILIZÂND TEHNICI DE
BIOLOGIE MOLECULARĂ ŞI ANALIZĂ STATISTICĂ
Grant Academia Romana 2007
Perioada: 2007-2009
Director proiect. Cheţa Dan Mircea
Buget 2007 – 5.000 RON
Proiecte PNCDI tip VIASAN, BIOTECH, etc.
1. TRANSPLANTUL DE INSULE PANCREATICE – O POSIBILĂ TERAPIE ÎN DIABETUL
ZAHARAT DE TIP 1
Proiect VIASAN, Contract 92/29.12.2001
Perioada 2001-2003
Director proiect – Prof. Constantin Ionescu-Tîrgovişte
Buget total 140.000 RON
2001 – 20.000 RON
2002 – 60.000 RON,
2003 – 60.000 RON
2. STUDIUL ACTIUNII INSULINOMIMETICE A VANADIULUI LA SOBOLANII BB DIABETICI
SI A EFECTELOR GENETICE INDUSE DE ACESTA
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Proiect VIASAN
Perioada 2003-2004
Contractant IDNBM N Paulescu
Director de proiect- Dr. Daniela Gutu
Fonduri – 95.000 RON
3. PRELEVAREA ŞI IZOLAREA INSULELOR PANCREATICE DE LA DIFERITE SPECII DE
PESTI IN VEDEREA STABILIRII COMPATIBILITĂŢII IMUNE ŞI LA OM. SURSE
ALTERNATIVE DE INSULE LANGERHANS FATA DE DONATORII UMANI.
Proiect PNCDI - VIASAN, Contract 257/27.10.2003 Acronim PESTRA
Perioada 2003 -2005
Buget 128.100 RON,
2003 – 62.700 RON,
2004 – 65.400 RON
Achizitionat – Sistem Laptop Travel Mate 2501 LC, in valoare de 6027,6 RON (2004)
4. UTILIZAREA UNOR GENE POLIMORFE ÎN STUDIUL DIABETULUI ZAHARAT ŞI A
COMPLICAŢIILOR VASCULARE ASOCIATE. (GENODIABET)
Proiect BIOTECH – PCD Contract No 3-288/01.10.2003
Perioada 2003 – 2005
Contractor titular - Institutul de Biologie şi Patologie Celulară Nicolae Simionescu
Responsabil ştiinţific de proiect- Dr. Cristian Guja din partea IDNBM ‖N. C. Paulescu‖;
Buget - 50.000 RON
2003 – 20.570 RON,
2004 – 10.900 RON
2005 – 18.530 RON
5. IDENTIFICAREA HAPLOTIPURILOR CU SEMNIFICAŢIE PREDICTIVĂ PENTRU EVOLUŢIA
BOLII RENALE LA PACIENŢII DIABETICI DIN ROMÂNIA
Proiect VIASAN Contract 415/2004
Director Proiect Dr. Cristian Serafinceanu
Partener - Universitatea din Bucuresti - Institutul de Genetica
Buget:
2004 – 3.000 RON
2005 – 7.000 RON
2006 – 4.000 RON
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6. SUSCEPTIBILITATEA GENETICĂ PENTRU NEFROPATIA DIABETICĂ LA PACIENŢII
CAUCAZIENI DIN ROMANIA.
Proiect CNCSIS, Cod CNCSIS-990
Perioada 2004-2005
Director Proiect – Prof. Dan Cheţa/Dr. C Serafinceanu
Buget:
2004 – 37.375 RON
2005 – 50.000 RON
7. ADIPONECTINA – MEDIATOR ÎN SEMNALIZAREA INTRA-CELULARĂ ACTIVATĂ DE
INSULINĂ – IMPLICAŢII CLINICE ÎN OBEZITATEA ASOCIATĂ CU DZ TIP 2.
Proiect VIASAN
Perioada 2004 - 2006
Contractor titular - Institutul de Biologie şi Patologie Celulară Nicolae Simionescu
Responsabil ştiinţific de proiect- Prof. Dr. C. Ionescu-Tirgoviste, din partea IDNBM ‖N. C. Paulescu‖
Proiecte CEEX
1. DEZVOLTAREA UNOR CENTRE CARDIOLOGICE DE DIAGNOSTIC PRECOCE PRIN
SCREENING AL POPULATIEI CU FACTORI DE RISC A DISFUNCTIEI CARDIACE
(CARDIOSCREEN)
Proiect CEEX
Perioada 2005-2008
Contractor titular - UMF Carol Davila Bucureşti
Responsabil ştiinţific de proiect- Prof. Dr. R. Lichiardopol, din partea IDNBM ‖N. C. Paulescu‖;
Buget:
2005 – 50.000 RON,
2006 – 20.000 RON,
2007 – 30.000 RON
Aparatură achiziţionată – Congelator -80 grade in valoare de 55.866 RON
2. INTERACTIUNI CALITATIVE DATORATE TRANSFORMARII SUBSTANTELOR NUTRITIVE
LIPIDICE PE LANTUL ALIMENTAR FURAJ-ANIMAL-CONSUMATOR UMAN IN VEDEREA
STABILIRII UNOR INDICATORI DE IMPACT ASUPRA SANATATII OMULUI‖â (LIPOSAN),
Proiect CEEX
Perioada 2005-2008
Contractor titular IBNA Balotesti
Responsabil ştiinţific de proiect- Prof. Dr. R. Lichiardopol, din partea IDNBM ‖N. C. Paulescu‖
Buget:
2006 – 600.000 RON,
2007 – 500.000 RON
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Aparatură achiziţionată – Aparat electroforeză SEBIAPHORESYS-ABT ~ 20.000 RON
3. ANALIZA FACTORILOR GENETICI CU POTENTIAL EFECT MODULATOR ASUPRA
DINAMICII MATRICEI EXTRACELULARE IN NEFROPATIA DIABETICA
Proiect CEEX cod 53/2005
Perioada 2005-2008
Director proiect Prof Dr Dan Mirce Cheţa
Partener - Universitatea din Bucuresti - Institutul de Genetica
Buget total: 260.000 RON
2005 – 20.000 RON
2006 – 170.000 RON
2007 – 70.000 RON
Aparatură achiziţionată: Ecograf portabil ALOKA, cu preţ de achiziţie de aprox. 100.000 RON (2006)
4. ALTERAREA MECANISMELOR CELULARE SI MOLECULARE SI A EXPRESIEI GENICE IN
BOLI CARDIOVASCULARE SI DIABET/OBEZITATE, AFECTIUNI MAJORE ALE
SINDROMULUI METABOLIC - CERCETARI FUNDAMENTALE SI CLINICE (AMCADO)
Proiect CEEX –Contract nr. 384/2005
Perioada 2005-2008
Contractor titular : Institutul de Biologie şi Patologie Celulară Nicolae Simionescu
Partener 2 : Institutul de diabet, Nutriţie şi Boli Metabolice „N. C. Paulescu‖, responsabil ştiinţific de
proiect - Asis. Univ. Dr. Ana-Maria Tinu
Buget Total – 120.000 RON
2005 – 10.000 RON
2006 – 40.000 RON
2007 – 50.000 RON
2008 – 20.000 RON
Aparatură achiziţionată: Laptop (2005 valoare 7.000 RON), Sistem CGMS Guardian (2006 valoare
14.280 RON)
5.
STUDIUL
BIOACTIVITĂŢII
SINERGICE
A
ALIMENTELOR
FUNCŢIONALE
ANTIOXIDANTE ÎN REVERSIBILITATEA SINDROMULUI METABOLIC (MET-ANTIOX)
Proiect CEEX - Contract CEEX 10/2005
Perioada 2005-2008
Contractor principal – UMF Victor Babes Timişoara
Responsabil ştiinţific de proiect- Conf. Gabriela Radulian, din partea IDNBM ‖N. C. Paulescu‖,
BUGET TOTAL: 190 000 RON
2007 - 105.850 RON
2008 - 84.650 RON
Aparatură achiziţionată 2007: Aparat determinare radicali liberi FORMOX, Centrifuga FORMOX,
Laptop, Xerox.
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6. EFICIENTA MANAGEMENTULUI INTENSIV NUTRITIONAL, FARMACOLOGIC SI
COMPORTAMENTAL AL OBEZITATII – CORELAREA FACTORILOR GENETICI,
BIOMORFOLOGICI SI PSIHOLOGICI
Proiect CEEX cod 163/2006,
Parteneri :
Universitatea din Bucuresti,
Asociatia Psihoterapii Cognitive si Comportamentale din Romania,
Fundatia pentru Alimentatie Sanatoasa
Director proiect – Prof. Dr. Dan Mircea Cheţa
Buget Total: 970.000 RON
2006 - 35.000 RON
2007 - 561.000 RON
2008 - 374.000 RON
Aparatură achiziţionată:
Sistem informatic tip Laptop – 7.000 RON Procesor Centrino 1,7 GHz, 15,4‖, 512Mb RAM, 80
Gb HDD
Aparat achizitie imagini cu capacitate de
Rezolutie (LF)/LN) 3456 x 2304, CMOS, Card
stocare – 2.700 RON
Memoire
Aparat determinare grad de ocluzie si
Fonocardiograma, Tensiunea arteriala masurata
rigiditate a sistemului vascular periferic –
concomitent la cele 4 membre, EKG - 1 derivatie
VASERA – 32.368 RON
Aprecierea gradului de ocluzie si rigiditate a
sistemului vascular periferic prin calcularea
Indexului ABI (ankle brachial index) si a Indexului
CAVI (cardio ankle vascular index)
Electrocardiograf – 7.497 RON
12 canale, afisare 3 canale simultan
Aparat RT PCR – 124.999,98 RON
Nr minim probe 8; 2 fluorocromi cu posibilitate de
crestere numarului a acestora; Soft inclus pentru
trasarea automata a curbei de fluorescenta;
Posibilitate upgradare soft; Alimentare 220V
7. DECOMPRESIA NERVOASĂ MINIM INVAZIVĂ
TRATAMENTUL NEUROPATIEI DIABETICE
–
O
SOLUŢIE
MODERNĂ
ÎN
Proiect CEEX
Perioada 2006-2008
Contractor principal – UMF Timişoara – Prof. Ionac
Responsabil ştiinţific de proiect- Prof. Dr. Dan Mircea Cheţa, din partea IDNBM ‖N. C. Paulescu‖
2007 – 75.000 RON
2008 - 75.000 RON
Aparatură achizitionata: 1. Aparat CASE IV - Sistem computerizat pentru evaluarea perceptiei vibratorii
si senzoriale (cald, rece) – 20.000 Euro; 2. Laptop TOSHIBA - 4.300 RON
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8.
STRATEGII
NOI
ÎN
CONDUITA
DIAGNOSTICĂ
ŞI
TERAPEUTICĂ
A
HIPERCOLESTEROLEMIEI FAMILIALE PRIN SCREENINGUL MOLECULAR AL MUTAŢIILOR
GENEI RECEPTORULUI LDL (HIFAGEN)
Proiect CEEX 143/2007
Perioada 2006-2008
Contractor Principal – Institutul de Boli Cardio-Vasculare „CC Iliescu‖ Bucureşti, Dr. Coman
Responsabil ştiinţific de proiect- Prof. Dr. Dan Mircea Cheţa, din partea IDNBM ‖N. C. Paulescu‖
2006 19.500 RON
2007 170.000 RON
2008 110.500 RON
Aparatură achizitionată:
Sistem informatic tip Laptop – 7000 RON Procesor Centrino 1,7 GHz, 15,4‖, 512Mb RAM, 80
Gb HDD
Calculator – 3565 RON
Procesor Pentium 4:2,4 GHz, Monitor 17‖, 1024 Mb
RAM, 80 Gb HDD
9. CERCETARI PRIVIND OBTINEREA SI CARACTERIZAREA UNUI NOU PRODUS
FARMACEUTIC DE NATURA VEGETALA CU ACTIUNE HIPOGLICEMIANTA
Proiect CEEX
Perioada 2006-2008
Parteneri:
1. UMF Carol Davila Bucureşti, Facultatea de Farmacie
2. Centrul de Cercetări Medico Militare Bucureşti
3. Biopharmacy & Pharmacology Research SA, Bucureşti
4. Institutul de Cercetări Chimico Farmaceutice Bucureşti
5. Fabiol SA Bucureşti
Buget 2008 – 400.000 RON
10. PROMOVAREA PARTICIPĂRII ROMÂNEŞTI LA PROIECTE EUROPENE FP7 ÎN
DOMENIUL IMUNOGENETICII DIABETULUI ZAHARAT SI AL MEDICINII REGENERATIVE
CU CELULE BETA PANCREATICE
Proiect CEEX Modul III
Perioada 2006-2008
Contractor Titular: - Spitalul Clinic Fundeni, Prof. Dr. Irinel Popescu
Responsabil ştiinţific de proiect - Prof. Dr. Constantin Ionescu-Tirgoviste, din partea IDNBM ‖N. C.
Paulescu‖
11. BIODISPONIBILITATEA SARURILOR MINERALE DIN PRODUSELE DE PANIFICATIE
IMBOGATITE IN FIBRE ALIMENTARE
13
Proiect CEEX
Perioada 2006-2008
Contractor principal: Institutul de Bioresurse Alimentare Bucuresti
Responsabil ştiinţific de proiect- Dr. Vladica Maria, din partea IDNBM ‖N. C. Paulescu‖,
Buget total: 150.000 RON
2006 - 15.000 RON
2008 - 135.000 RON
12. IMPACTUL ALIMENTELOR FUNCŢIONALE MULTICOMPONENT ÎN COMBATEREA
OBEZITĂŢII ŞI ATEROSCLEROZEI (ANTIATERO-ALIM)
Proiect CEEX Contract 44/2006
Perioada 2006-2008
Contractor principal – UMF „Victor Babes‖ Timişoara
Responsabil ştiinţific de proiect- Conf. Gabriela Radulian, din partea IDNBM ‖N. C. Paulescu‖,
BUGET TOTAL: 150 000 RON
2006: 43.100 RON
2007: 48.000 RON
2008: 58.900 RON
Aparatură achiziţionată:
2006 - Aparat Bioimpedanţă BIOSPACE INBODY 320
2007 - EKG; - Videoproiector
13. OPTIMIZAREA DIAGNOSTICULUI PRECOCE IN ADENOCARCINOMUL PROSTATIC LA
PACIENTI CU SINDROM METABOLIC PRIN CORELAREA FACTORILOR GENETICI,
ANATOMOPATOLOGICI SI BIOCHIMICI (ADENODIAG)
Proiect CEEX2 Contract nr 41-085
Perioada 2007 - 2010
Contractor titular: SCUMC ―Carol Davila‖ Bucureşti
Responsabil stiintific de proiect - Prof. Dr. Dan Mircea Cheţa din partea IDNBM ‖N. C. Paulescu‖
2007 - 83.000 RON
2008 - 269.180 RON
2009 - 220.860 RON
2010 - 38.760 RON
14. STUDIUL MECANISMELOR CELULARE, MOLECULARE SI GENICE PRIN CARE
DISLIPIDEMIA INDUCE REZISTENTA LA INSULINA ; IDENTIFICAREA DE COMPUSI
PROBIOTICI ACTIVI SI METODE DE TRATAMENT
Proiect CEEX2
Perioada 2007-2010
Contractor titular: Institutul de Biologie şi Patologie Celulară „Nicolae Simionescu‖ Bucureşti
Responsabil ştiinţific de proiect – Dr. Maria. Vlădică, din partea IDNBM ‖N. C. Paulescu‖
Buget Total 400.000 RON
2007 - 12.650 RON
14
2008 -161.300 RON
2009 – 148.500 RON
2010 – 77.550 RON
15. ADIPOCITOKINELE, PUNTE DE LEGATURA INTRE HEPATITA CU VIRUS C SI DIABETUL
ZAHARAT TIP 2 (DIADIPOHEP)
Proiect CEEX2 Contract nr 41-008
2007-2010
Contractor titular: IDNBM ―Prof. N. Paulescu‖
Director de proiect Conf. Univ. Dr. Gabriela Radulian
2007 - 85.030 RON
2008 - 261.330 RON
2009 - 226.340 RON
2010 - 56.500 RON
7.4. Numărul şi valoarea contractelor de cercetare naţionale finanţate din fonduri private:
7.5. Alte surse: - Nu este cazul
7 bis. Venituri realizate din activităţi economice (servicii, microproducţie): Nu este cazul
8. Resursa umană de cercetare
(situaţia va fi prezentată pe ani)
8.1. Total personal de cercetare care realizează venituri din activitatea de cercetaredezvoltare/din care doctori în ştiinţă:
2003
2004
2005
2006
2007
14/6
16/6
16/6
16/6
7/5
Excluzând Asistenţii de Cercetare, Numărul mediu de personal de cercetare pe perioada de
5 ani raportată a fost 12 + 12 + 12 + 14 + 7 = 57/5 = 11.4 persoane/an
8.1.1. Cercetători ştiinţifici gradul 1 (profesori)/din care doctori în ştiinţă:
2003
2004
2005
2006
2007
3/3
3/3
3/3
3/3
3/3
15
8.1.2. Cercetători ştiinţifici gradul 2 (conferenţiari)/din care doctori în ştiinţă:
2003
2004
2005
2006
2007
2/2
2/2
2/2
2/2
1/1
8.1.3. Cercetători ştiinţifici gradul 3 (lectori)/din care doctori în ştiinţă:
2007
1/1
8.1.4. Cercetători ştiinţifici/din care doctori în ştiinţă:
2003
2004
2005
2006
2007
7/1
7/1
7/1
9/1
2/0
8.1.5. Asistenţi de cercetare:
2003
2004
2005
2006
2007
2/0
4/0
4/0
2/0
0/0
8.1.6. Total personal auxiliar de cercetare angajat: - nu este cazul
8.2. Date privind perfecţionarea resursei umane
8.2.1. Număr de doctoranzi şi masteranzi care lucrează în unitatea de cercetare-dezvoltare la
data completării formularului: 25 doctoranzi
8.2.2. Număr de teze de doctorat realizate în unitatea de cercetare-dezvoltare în perioada
pentru care se face evaluarea: 8 teze de doctorat susţinute
9. Infrastructura de cercetare-dezvoltare
9.1. Laboratoare de cercetare-dezvoltare: Nu este cazul
Nr. crt. Denumirea laboratorului
Domeniul în care este acreditat
9.2. Lista echipamentelor performante achiziţionate în ultimii 10 ani:
16
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
Dispozitiv
Maşină de spălat industrială
Hotă de laborator
Biomicroscop Zeiss
Calculator Pentium
Calculator Laptop
Calculator Notebook
Analizor ANALOX GM9
Analizor glucoză
Multifuncţional Minolta
Maşină de Spălat Legume
Maşină de pasat piure
Videoproiector
Cameră Foto Digitală
Imprimantă
Calculatoare
Angiofluorograf Digital
Analizor Urini
Centrifugă Sterilizare
Centrifugă Laborator
Autoclav Laborator
Termostat Laborator
Etuvă Sterilizare
Lampă UV
Sterilizator Laborator
Centrală Telefonică
Calculator Laptop
Calculator Laptop
Calculator Laptop
Centrifugă Laborator
Ecocardiograf
Calculatoare
Data
achizitiei
21.11.2003
18.12.2003
19.12.2003
24.11.2003
18.12.2003
31.05.2004
17.06.2004
30.09.2004
26.10.2004
28.10.2004
28.10.2004
29.11.2004
29.11.2004
10.11.2004
21.10.2004
14.12.2004
20.07.2005
20.07.2005
20.07.2005
28.07.2005
28.07.2005
28.07.2005
28.07.2005
29.09.2005
21.11.2005
08.12.2005
08.12.2005
08.12.2005
16.12.2005
22.12.2005
12.12.2005
An
fabricatie
2003
2003
2003
2003
2003
2004
2004
2004
2004
2004
2004
2004
2004
2004
2004
2004
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
Unitati
2
1
2
1
1
3
2
1
1
1
1
1
1
1
5
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
3
Valoare
(RON)
59677,99
17865,54
98946,12
3063,99
10943,59
18117,09
96390
10872,37
11017,91
4352,85
4352,85
8757,19
9981,83
3924,62
19908,7
14978,29
3593,8
14898,8
7497
21578,86
10799,25
7199,5
1999,2
21578,86
19862,69
7439,88
5745,32
8407,35
19825,83
298690
9928,17
Analizor Biochimie Hitachi
2005
2005
1
360463
Microscop Medrom
2005
2005
1
345885,08
Staţie de lucru PC
2006
2006
1
55038,87
Centrifugă tip Bench
Congelator
Ecograf
Hotă laborator
Climatizor
Sistem Electroforeză
Calculatoare PC
2006
2006
2006
2006
2006
2006
2006
2006
2006
2006
2006
2006
2006
2006
1
1
1
1
6
1
9
62336,22
55866,14
118494,05
14497,77
17282,37
20000
32086,41
Sursa
Fondurilor
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Ministerul
Sănătăţii
Ministerul
Sănătăţii
Fonduri
PHARE
Fonduri
PHARE
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
17
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
Aparat foto Digital
Smart Phome
Calculatoare
Calculator Notebook
Calculator Notebook
Sistem Momitorizare Glicemie
Analizor Inbody
Microscop NIKON
Calculator Laptop
Videoproiector
Electrocardiograf
Calculatoare
Aparat determinare impuls
nervos
Autoturism Logan
Analizor Genetică RT-PCR
Aparat determinare grad
ocluzie vasculară
Electrocardiograf
Calculator Notebook
Calculator Notebook
Calculator Notebook
Aparat determinare radicali
liberi
Xerox
Multifuncţional HP
Multifuncţional Samsung
Calculator Laptop
Calculatoare PC
Analizor CR
Sondă transrectală
Videoprinter
Centrifugă laborator
Calandru
2006
2006
2006
2006
2006
2006
2006
2006
2007
2007
2007
2007
2006
2006
2006
2006
2006
2006
2006
2006
2007
2007
2007
2007
1
1
11
1
1
1
1
1
1
1
1
12
2953,52
2998,84
39216,72
7000
7000
14280
41769
12603,6
3702,09
8000
15899,99
32231,82
2007
2007
2007
2007
2007
2007
1
1
1
20000
37981,87
124999,98
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
1
1
1
1
1
32368
7497
7790,93
4200,7
3702,09
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
1
1
1
1
2
3
1
1
1
1
1
17000
26556,04
6240,36
3160
13119,99
8063,88
17998,75
7973
3986,5
9996
29988
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
Surse Proprii
------------------------------1)
Se menţionează forma de organizare şi persoana juridică: dacă unitatea de cercetare-dezvoltare
nu are personalitate juridică, se menţionează denumirea instituţiei cu personalitate juridică care o
reprezintă (de exemplu, Centrul de ............... din cadrul Universităţii ...............).
2)
Se menţionează titlul actului, data emiterii, organul emitent şi, după caz, modificările
ulterioare.
3)
Domeniile de clasificare UNESCO pot fi accesate la www.mct.ro/ancs.
18
4)
Indexate de Thomson Scientific [fost Institute for Scientific Information (ISI) in Science
Citation Index Expanded, Social Sciences Citation Index sau Arts & Humanities Citation Index].
5)
Punctajul ISI se obţine prin însumarea factorilor de impact ai publicaţiilor respective. Factorii
de impact pot fi accesaţi la www.cimec.org.ar.
6)
Sunt excluse autocitările.
7)
Se specifică dacă brevetul este naţional/internaţional (USPTO, EPO, JPO) şi numărul
brevetului.
8)
În cazul revistelor româneşti, sunt luate în considerare cele cotate CNCSIS, categoria B (vezi
www.cncsis.ro).
9)
Valori defalcate pe ani şi valoarea totală în euro.
10)
Datele vor fi prezentate pe tipuri de programe (PNCDI, CEEX, granturi etc.); valorile
contractelor vor fi defalcate pe ani.
19
ANEXA 4.1
LISTA LUCRĂRILOR ŞI CITĂRILOR
20
Anexa 4.1
ARTICOLE FULL TEXT PUBLICATE ÎN REVISTE INDEXATE ISI
2003
1. Cheta D, Orasanu G, Nicolaie T, Iordachescu D, Buligescu S, Constantin C, Hassanain M, Coman
A, Enache M, Negru R, Tica V, Timofte D, Gutu D, Panaite C. (2003) The influence of sodium
metavanadate on the process of diabetogenesis in BB rats. J Cell Mol Med 7:447-454 Impact Factor
2003: 1.694
2. Maier LM, Twells RCJ, Howson JMM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D,
Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E,
Tuomilehto J, Guja C, Ionescu-Tîrgovişte C, Undlien DE, Rønningen KS, Cucca F, Todd JA.
(2003) Testing the possible negative association of type 1 diabetes and atopic disease by analysis of
the interleukin 4 receptor gene. Genes and Immunity 4:469–475 Impact Factor 2003: 3.637
3. Marre M, Garcia Puig J, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A,
Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz M, Hermansen K,
Tuomilehto J, Finizola B, Pozza G, Chastang C, Ollivier JP, Amouyel P, Asmar R. (2003) Effect of
indapamide SR on microalbuminuria--the NESTOR study (Natrilix SR versus Enalapril Study in
Type 2 diabetic hypertensives with micrOalbuminuRia)--rationale and protocol for the main trial. J
Hypertens Suppl 21:S19-24 Impact Factor 2003: 3.572
4. Nejentsev S, Guja C, McCormack R, Cooper J, Howson JMM, Nutland S, Rance H, Walker N,
Undlien D, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-Tîrgovişte C, Gale EAM,
Bingley PJ, Gillespie KM, Savage DA, Carson DJ, Patterson CC, Maxwell AP, Todd JA. (2003)
Association of intercellular adhesion molecule-1 gene with type 1 diabetes. Lancet 362:1723-1724
Impact Factor 2003: 18,316
5. Ueda H, Howson JMM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter
KMD, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RCJ,
Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM,
Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A,
Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE,
Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC,
Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SCL. (2003) Association of
the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-511
Total Impact Factor 2003 = 58,198
2004
6. Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N,
McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tirgoviste C, Undlien DE,
Ronningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell
HJ, Todd JA. (2004) Remapping the Insulin Gene/IDDM2 locus in Type 1 diabetes. Diabetes
53:1884-1889 Impact Factor 2004: 8,848
21
7. Eftychi C, Howson JMM, Barratt B, Vella A, Payne F, Smyth DJ, Twells RCJ, Walker NM, Rance
H, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C,
Savage D, Todd JA. (2004) Analysis of the type 2 diabetes - associated single nucleotide
polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. Diabetes 53:870-873
8. Guja C, Guja L, Nutland S, Rance H, Sebastien M, Todd JA, Ionescu-Tirgoviste C. (2004) Type 1
diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania. J Cell Mol Med 8:249256. Impact Factor 2004: 2.153
9. Hulme JS, Barratt BJ, Twells RCJ, Cooper JD, Lowe CE, Howson JMM, Lam AC, Smink L, Savage
DA, Undlien DE, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA. (2004)
Association analysis of the lymphocyte-specific protein tyrosine kinase (LKC) gene in type 1
diabetes. Diabetes 53:2479-2482 Impact Factor 2004: 8,848
10. Ionescu-Tîrgovişte C, Guja C, Călin A, Moţa M. (2004) An increasing trend in the incidence of type
1 diabetes in children aged 0 – 14 years in Romania. Ten years (1988 – 1997) EURODIAB study
experience. J Ped Endocrinol Metab 17:983-991 Impact Factor 2004: 0,903
11. Kyvik KO, Nystrom L, Gorus F, Songini M, Oestman J, Castell C, Green A, Guyrus E, IonescuTirgoviste C, McKinney PA, Michalkova D, Ostrauskas R, Raymond NT. (2004) The epidemiology
of Type 1 diabetes mellitus is not the same in young adults as in children. Diabetologia 47:377-384
Impact Factor 2004: 5.583
12. Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RCJ, Green EA, Savage DA, Guja C,
Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG. (2004) Costeffective analysis of candidate genes using htSNPs: a staged approach. Genes and Immunity 5:301–
305 Impact factor 2004: 3,718
13. Marre M, Puig JG, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A, IonescuTirgoviste C, Saldanha MH, Halabe A, Williams B, Mion Junior D, Ruiz M, Hermansen K,
Tuomilehto J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R. (2004) Equivalence of
indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2
diabetes: the NESTOR Study. J Hypertens 22:1613-1622 Impact Factor 2004: 4.871
14. Nejentsev S, Cooper JD, Godfrey L, Howson JM, Rance H, Nutland S, Walker NM, Guja C,
Ionescu-Tirgoviste C, Savage DA, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J,
Gillespie KM, Ring SM, Strachan DP, Widmer B, Dunger D, Todd JA. (2004) Analysis of the
vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes 53:2709-2712 Impact Factor
2004: 8,848
15. Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, IonescuTirgoviste C, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton
DG, Todd JA. (2004) Comparative high-resolution analysis of linkage disequilibrium and tag single
nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet
13:1633-1639 Impact Factor 2004: 7,801
16. Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance
HE, Maier L, Barratt BJ, Guja C, Ionescu-Tirgoviste C, Savage DA, Dunger DB, Widmer B,
Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA. (2004) Replication
of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1
diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53:3020-3023 Impact
Factor 2004: 8,848
17. Vella A, Howson JMM, Barratt B, Twells RCJ, Rance H, Nutland S, Tuomilehto-Wolf E,
Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage D, Todd JA.
(2004) Lack of association of the Ala45Thr polymorphism and other common variants of the NeuroD
gene with type 1 diabetes. Diabetes 53:1158-1161 Impact Factor 2004: 8,848
22
Total Impact Factor 2004 = 78,117
2005
18. Ionescu-Tirgoviste C. (2005) Comment on: Godsland IF, Jeffs JAR, Johnston DG (2004) Loss of
beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-1166.
Diabetologia 48:203-24 Impact Factor 2005: 5.337
19. Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H,
Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE, Ronningen KS, Guja C,
Ionescu-Tirgoviste C, Savage DA, Strachan DP, Peterson LB, Todd JA, Wicker LS, Twells RC.
(2005) Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse
orthologous candidate genes in type 1 diabetes. BMC Genet 6:9 Impact Factor 2005: 1.769
20. Payne F, Smyth DJ, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G, Szeszko J,
Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE, Ronningen KS, Guja
C, Ionescu-Tirgoviste C, Todd JA, Twells RC. (2005) No evidence for association of the TATA-box
binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1
diabetes. Biochem Biophys Res Commun. 331:435-41 Impact Factor 2005: 3
21. Pozzilli P, Manfrini S, Buzzetti R, Lampeter E, Leeuw ID, Iafusco D, Prisco M, Ionescu-Tirgoviste
C, Kolouskova S, Linn T, Ludvigsson J, Madacsy L, Mrozikiewicz AS, Mrozikiewicz PM, Podar T,
Vavrinec J, Vialettes B, Visalli N, Yilmaz T, Browne PD; IMDIAB group. (2005) Glucose
evaluation trial for remission (GETREM) in type 1 diabetes: a European multicentre study. Diabetes
Res Clin Pract 68:258-264 Impact Factor 2005: 1.236
22. Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf
E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB,
Twells RC, McArdle WL, Strachan DP, Todd JA. (2005) Assessing the validity of the association
between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet 37:110-111 Impact Factor
2005: 25.797
23. Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, Witte DR, Fuller JH;
EURODIAB Prospective Complications Study Group. (2005) Vascular risk factors and diabetic
neuropathy. N Engl J Med 2005 352:341-350 Impact factor 2005: 44,016
Total Impact Factor 2005 = 81.155
2006
24. Cheta DM. (2006) The metabolic syndrome: Time for a critical appraisal: Joint statement from the
American Diabetes Association and the European Association for the Study of Diabetes: Response
to Kahn et al. Diabetes Care 29:176-177 Impact factor 2006: 7,912
25. Ionescu-Tîrgovişte C, Ioacără S, Guja C, Sabău S, Lichiardopol R, Mihai A, Apetrei E. (2006) A
pathophysiological approach to metabolic syndrome using factor analysis in an adult Romanian
population. Arch Physiol Biochem 112:182-188
26. Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, Ionescu-Tirgoviste C,
Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA. (2006) A genome-wide
association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferoninduced helicase (IFIH1) region. Nat Genet 38:617-619 Impact factor 2006: 24.176
23
Total Impact Factor 2006 =32,088
2007
27. Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field
SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JHM, Vella A, Nutland S, Stevens
HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam
AAC, Ovington NR, Allen J, Adlem E, Leung H-T, Wallace C, Howson JMM, Guja C, IonescuTîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SCL,
Dunger DB, the Wellcome Trust Case Control Consortium, Wicker LS & Clayton DG. (2007)
Robust associations of four new chromosome regions from genome-wide analyses of type 1
diabetes. Nat Genet 39:857 – 864 Impact factor 2006: 24.176
28. Coculescu M, Niculescu D, Lichiardopol R, Purice M. (2007) Insulin resistance and insulin secretion
in non-diabetic acromegalic patients. Exp Clin Endocrinol Diabetes 115:308-316 Impact factor
2006: 1.356
29. Puig JG, Marre M, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A, IonescuTirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz M, Hermansen K, Tuomilehto
J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R. (2007) Efficacy of indapamide SR
compared with enalapril in elderly hypertensive patients with type 2 diabetes. Am J Hypertens
20:90-97 Impact factor 2006: 3.116
Total Impact Factor 2007 = 28.648
Punctaj ISI cumulat 2003-2007 = 278.206
24
Anexa 4.1
CITĂRI ÎN REVISTE INDEXATE INTERNAŢIONAL OBŢINUTE CU
MOTORUL DE CĂUTARE GOOGLE SCHOLAR
Cheta D, Orasanu G, Nicolaie T, Iordachescu D, Buligescu S, Constantin C, Hassanain
M, Coman A, Enache M, Negru R, Tica V, Timofte D, Gutu D, Panaite C. (2003) The
influence of sodium metavanadate on the process of diabetogenesis in BB rats. J Cell Mol
Med 7:447-454
The influence of sodium metavanadate on the process of diabetogenesis in BB rats - all 3 versions »
D Cheta, G Orasanu, T Nicolaie, D Iordachescu, S … - J. Cell. Mol. Med, 2003 - Blackwell Synergy
... diabetes. There is great interest in orally The influence of sodium metavanadate
on the process of diabetogenesis in BB rats D. Cheta ...
Cited by 3 - Related Articles - Web Search
DINTRE CITĂRI, PENTRU EVALUARE LISTĂM URMĂTOARELE ARTICOLE ÎN
REVISTE INDEXATE ISI:
1. Combined effect of vanadium (V) and chromium (III) on lipid peroxidation in liver and kidney of rats all 5 versions »
A Ścibior, H Zaporowska, J Ostrowski, A Banach - Chemico-Biological Interactions, 2006 - Elsevier
Since chromium(III) was demonstrated to have antioxidative action, we have
decided to study the effect of this element on V-induced LPO in liver and kidney
of rats. Outbred 2-month-old, albino male Wistar rats received daily, for a ...
2. Stat5 constitutive activation rescues defects in spinal muscular atrophy - all 5 versions »
CH Ting, CW Lin, SL Wen, HM Hsieh-Li, H Li - Human Molecular Genetics, 2007 - Oxford Univ Press
Proximal spinal muscular atrophy (SMA) is a motor neuron degeneration disorder
for which there is currently no effective treatment. Here, we report three
compounds (sodium vanadate, trichostatin A and aclarubicin) that ...
Related Articles - Web Search - BL Direct
3. Effects of Vanadium (V) and/or Chromium (III) on L-Ascorbic Acid and Glutathione as well as Iron, …
- all 2 versions »
A Scibior - Journal of Toxicology and Environmental Health, Part A, 2007 - informaworld.com
Journal of Toxicology and Environmental Health, Part A, 70: 696–704, 2007
Copyright © Taylor & Francis Group, LLC ISSN: 1528-7394 print / 1087-2620
online DOI: 10.1080/15287390601187906 ... UTEH Effects of Vanadium(V) ...
TOTAL CITĂRI - 3
25
Maier LM, Twells RCJ, Howson JMM, Lam AC, Clayton DG, Smyth DJ, Savage D,
Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H,
Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgovişte C, Undlien DE,
Rønningen KS, Cucca F, Todd JA. (2003) Testing the possible negative association of
type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes
and Immunity 4:469–475
Testing the possible negative association of type 1 diabetes and atopic disease by analysis
of the … - all 3 versions »
… Rance, E Tuomilehto-Wolf, J Tuomilehto, C Guja, C … - Genes and Immunity, 2003 - nature.com
T1D is caused by autoimmune destruction of pancreatic islet -cells, a process
that is genetically determined and susceptible to major, and as yet unknown,
environmental factors. 9 The disease is characterised by inflammation of ...
1. No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes all 5 versions »
LM Maier, J Chapman, JM Howson, DG Clayton, R Pask … - Am J Hum Genet, 2005 - UChicago Press
The genetic analysis of common, multifactorial diseases, such as type 1 diabetes
(T1D [MIM 222100]), that are highly clustered in families is proving to be a
challenging task (Altmuller et al. 2001; Hirschhorn et al. 2002; Ioannidis ...
2. Coexistence of IgE-Mediated Allergy and Type 1 Diabetes in Childhood - all 6 versions »
C Caffarelli, G Cavagni, R Pierdomenico, G Chiari, … - Int Arch Allergy Immunol, 2004 content.karger.com
Background: Autoimmune disorders are considered to be associated with a Th1
immune response while allergic diseases with a Th2 response. We carried out a
study to determine whether there is an inverse relationship between ...
3. NON-MHC genes in type 1 diabetes. Family-based association studies and functional studies of disease
… - all 3 versions »
OP Kristiansen - Danish Medical Bulletin, 2005 - danmedbul.dk
Type 1 diabetes mellitus (T1DM), formerly called insulin-dependent diabetes
mellitus (IDDM), is a serious chronic disorder characterised by absolute insulin
deficiency caused by an immune-mediated selective destruction of the ...
Related Articles - Cached - Web Search
4. Lack of association of type 1 diabetes with the IL4R gene - all 3 versions »
HQ Qu, MC Tessier, R Fréchette, F Bacot, C … - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis: The association between IL4R and type 1 diabetes has
been tested in many studies in recent years, with contradictory results. The aim
of this study was to re-evaluate the genetic association in type 1 diabetic ...
Related Articles - Web Search
TOTAL CITĂRI - 4
26
Marre M, Garcia Puig J, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V,
Scheen A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz
M, Hermansen K, Tuomilehto J, Finizola B, Pozza G, Chastang C, Ollivier JP, Amouyel
P, Asmar R. (2003) Effect of indapamide SR on microalbuminuria--the NESTOR study
(Natrilix SR versus Enalapril Study in Type 2 diabetic hypertensives with
micrOalbuminuRia)--rationale and protocol for the main trial. J Hypertens Suppl 21:S1924
Effect of indapamide SR on microalbuminuria--the NESTOR study (Natrilix SR versus Enalapril Study in
M Marre, J Garcia Puig, F Kokot, M Fernandez, G … - J Hypertens Suppl, 2003 - ncbi.nlm.nih.gov
... Marre M, Garcia Puig J, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen
A, Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion D Jr, Ruiz ...
1. Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients … all 4 versions »
M Marre, JG Puig, F Kokot, M Fernandez, G Jermendy … - J Hypertens, 2004 - jhypertension.com
August 2004, 22:8 > Equivalence of indapamide SR and... ...
2. Response
JP Ruiz, LM Medina, FM Parra, JM de la Higuera … - Stroke, 2003 - Am Heart Assoc
We agree that the use of ACEI might be beneficial, but, although members of a
drug class share main actions, they may have clinically important differences in
terms of efficacy and safety, 6 which might explain the differences ...
TOTAL CITĂRI - 2
27
Nejentsev S, Guja C, McCormack R, Cooper J, Howson JMM, Nutland S, Rance H,
Walker N, Undlien D, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, IonescuTîrgovişte C, Gale EAM, Bingley PJ, Gillespie KM, Savage DA, Carson DJ, Patterson
CC, Maxwell AP, Todd JA. (2003) Association of intercellular adhesion molecule-1 gene
with type 1 diabetes. Lancet 362:1723-1724
Association of intercellular adhesion molecule-1 gene with type 1 diabetes - all 5
versions »
S Nejentsev, C Guja, R McCormack, J Cooper, JMM … - The Lancet, 2003 - Elsevier
Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the
leucocyte integrins, in adhesion of immune cells to endothelial cells and in T
cell activation. The third immuno-globulin-like extracellular domain binds ...
1. Getting under the skin: the immunogenetics of psoriasis.
AM Bowcock, JG Krueger - Nat Rev Immunol, 2005 - ncbi.nlm.nih.gov
Psoriasis is a chronic inflammatory disorder of the skin that is mediated by T
cells, dendritic cells and inflammatory cytokines. We now understand many of the
cellular alterations that underlie this disease, and genomic approaches ...
2. Type 1 diabetes: pathogenesis and prevention - all 12 versions »
KM Gillespie - Canadian Medical Association Journal, 2006 - Can Med Assoc
Type 1 diabetes results from the autoimmune destruction of insulin-producing ß
cells in the pancreas. Genetic and, as yet undefined, environmental factors act
together to precipitate the disease. The excess mortality associated with ...
Cited by 15 - Related Articles - Web Search - BL Direct
3. ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1
B Puthothu, M Krueger, M Bernhardt, A Heinzmann - Genes and Immunity, 2006 - nature.com
Intercellular adhesion molecule-1 (ICAM1) acts as ligand for 2-integrin
molecules and mediates leucocyte trafficking to the site of inflammation.
Intercellular adhesion molecule-1-deficient mice show impaired lymphocyte ...
4. Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary
sclerosing … - all 2 versions »
CL Bowlus, TH Karlsen, U Broomé, E Thorsby, M … - Journal of Hepatology, 2006 - Elsevier
Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in
the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing
cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been ...
5. ICAM-1 polymorphisms and development of cutaneous malignant melanoma - all 3 versions »
WM Howell, MJ Rose-Zerilli, JM Theaker, AC Bateman - Int. J. Immunogenet, 2005 ingentaconnect.com
Summary Tumour growth in cutaneous malignant melanoma (CMM) is mediated by cell
adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1).
ICAM-1 expression is associated with increasing Breslow thickness of ...
6. Adulthood-Onset Celiac Disease Is Associated with Intercellular Adhesion Molecule-1 (ICAM-1) Gene
28
M Abel, C Cellier, N Kumar, N Cerf-Bensussan, J … - Human Immunology, 2006 - Elsevier
Celiac disease (CD) is a multifactorial T-cell–mediated autoimmune disease
characterized by gluten-triggered villous atrophy and malabsorption. Although
human leukocyte antigen (HLA) class II genes are strong susceptibility ...
7. Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in … - all 6
versions »
J Ma, A Möllsten, M Prázny, H Falhammar, K … - Diabet Med, 2006 - Blackwell Synergy
Results SNPs rs281432(C/G) and rs5498 E469K(A/G) had high heterozygous indexes.
They were significantly associated with T1D [P = 0.026, OR = 1.644 (95% CI
1.138–2.376) and P < 0.001, OR = 2.456 (1.588–3.8)]. Frequencies of the ...
8. Association of intercellular adhesion molecule 1 polymorphisms with retinopathy in Chinese patients …
- all 4 versions »
L Liu, Q Yu, H Wang, SX Zhang, C Huang, X Chen - Diabetic Medicine, 2006 - Blackwell Synergy
Patients and methods One hundred and seventy-two Chinese patients with Type 2
diabetes and 80 normal control subjects were recruited. Patients with diabetes
were placed into two groups: the diabetic retinopathy (DR) group and the ...
9. Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical … - all
6 versions »
BR Yacyshyn, A Schievella, KL Sewell, JA Tami - Clinical and Experimental Immunology, 2005 Blackwell Synergy
Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/
perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms
in tumour necrosis factor (TNF)- and intercellular adhesion molecule-1 ...
10. NON-MHC genes in type 1 diabetes. Family-based association studies and functional studies of disease
OP Kristiansen - Danish Medical Bulletin, 2005 - danmedbul.dk
Type 1 diabetes mellitus (T1DM), formerly called insulin-dependent diabetes
mellitus (IDDM), is a serious chronic disorder characterised by absolute insulin
deficiency caused by an immune-mediated selective destruction of the ...
Related Articles - Cached - Web Search
TOTAL CITĂRI - 10
29
Ueda H, Howson JMM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB,
Hunter KMD, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe
C, Twells RCJ, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam
AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker
ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E,
Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, IonescuTîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton
DG, Peterson LB, Wicker LS, Todd JA, Gough SCL. (2003) Association of the T-cell
regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-511
Association of the T-cell regulatory gene CTLA 4 with susceptibility to
autoimmune disease - grup din 5 »
[PDF]
H Ueda, JMM Howson, L Esposito, J Heward, H Snook, … - Nature, 2003 - research.dfci.harvard.edu
Page 1. Association of the T-cell regulatory ... of the cytotoxic T lymphocyte antigen
4 gene (CTLA4)—which encodes a vital negative regulatory molecule of ...
Citat de 678 ori - Articole înrudite - Afişare ca HTML - Căutare Web
1. Naturally arising CD4 regulatory T cells for immunologic self-tolerance and negative control of … grup din 6 »
S Sakaguchi - Annu. Rev. Immunol, 2004 - Annual Reviews
Abstract Naturally occurring CD4 + regulatory T cells, the majority of which
express CD25, are engaged in dominant control of self-reactive T cells,
contributing to the maintenance of immunologic self-tolerance. Their ...
Citat de 847 ori - Articole înrudite - Căutare Web
2. Naturally arising Foxp3-expressing CD25 CD4 regulatory T cells in immunological tolerance to self … grup din 7 »
S Sakaguchi - Nature Immunology, 2005 - nature.com
A key issue in immunology is understanding how the immune system is able to
discriminate between self and non-self, inhibiting autoimmune responses but
allowing effective immune responses against microbial antigens. The immune ...
3. Genome-wide association studies for common diseases and complex traits - grup din 10 »
JN Hirschhorn, MJ Daly - Nature Reviews Genetics, 2005 - binfo.bio.wzw.tum.de
We have recently seen the completion of the human genome sequence 1,2 , the
deposition of millions of SNPs into public databases 3 ,rapid improvements in
SNP genotyping technology and the initiation of the International HapMap ...
4. Genome-wide association studies: theoretical and practical concerns - grup din 8 »
S Lin, A Chakravarti, DJ Cutler - Nature Genetics, 2004 - nature.com
Risch and Merikangas argued that in an idealized future, disease-association
studies could be carried out with substantial power by typing roughly 1 million
functional single-nucleotide polymorphisms (SNPs; or perfect proxies) in ...
5. Assessing the impact of population stratification on genetic association studies - grup din 5 »
ML Freedman, D Reich, KL Penney, GJ McDonald, AA … - Nature Genetics, 2004 - nature.com
Nature Genetics, Full text access provided to: Googlebot Access by: Web Services. ...
30
6. Genetics of multiple sclerosis - grup din 4 »
DA Dyment, GC Ebers, A Dessa Sadovnick - Lancet Neurology, 2004 - Elsevier
Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic
genetic epidemiological and molecular genetic studies have provided important
insights. Both genetic and non-genetic (environment, stochastic) factors ...
7. Strategies for mapping and cloning quantitative trait genes in rodents - grup din 8 »
J Flint, W Valdar, S Shifman, R Mott… - Nature Reviews Genetics, 2005 - nature.com
Many quantitative phenotypes of biomedical interest can be modelled in rodents,
and the chromosomal locations of the genetic variants that contribute to
phenotypic variation can be identified by crosses between inbred strains. ...
8. Genome scans and candidate gene approaches in the study of common diseases and variable drug … grup din 4 »
DB Goldstein, KR Ahmadi, ME Weale, NW Wood - Trends in Genetics, 2003 - Elsevier
There is both tremendous enthusiasm and controversy surrounding genetic
association studies. In this article we use new methods for representing
variation in the human genome that suggest as a few as 170 000 care- fully ...
9. What makes a good genetic association study? - grup din 4 »
AT Hattersley, MI McCarthy - The Lancet, 2005 - Elsevier
Genetic association studies are central to efforts to identify and characterise
genomic variants underlying susceptibility to multifactorial disease. However,
obtaining robust replication of initial association findings has proved ...
10. Methods for High-Density Admixture Mapping of Disease Genes - grup din 7 »
N Patterson, N Hattangadi, B Lane, KE Lohmueller, … - The American Journal of Human Genetics,
2004 - UChicago Press
In the search for disease-causing variants in humans, it is desirable to use
whole-genome scans, because they do not require a priori knowledge of the genes
involved in disease. The most successful such method to date linkage ...
TOTAL CITĂRI - 10
31
Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani
N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tirgoviste C, Undlien
DE, Ronningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST,
Clayton DG, Cordell HJ, Todd JA. (2004) Remapping the Insulin Gene/IDDM2 locus in
Type 1 diabetes. Diabetes 53:1884-1889.
Remapping the insulin gene/IDDM2 locus in type 1 diabetes. - all 3 versions »
BJ Barratt, F Payne, CE Lowe, R Hermann, BC Healy, … - Diabetes, 2004 - ncbi.nlm.nih.gov
Click here to read Remapping the insulin gene/IDDM2 locus in type 1 diabetes.
Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold ...
1. Genome-wide association studies for common diseases and complex traits - all 10
versions »
2. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag singlenucleotide … - all 5 versions »
A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - Am J Hum Genet, 2005 - UChicago Press
Despite hundreds of association studies, few have been consistently replicated
(Dahlman et al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller
et al. 2003). In type 1 diabetes (T1D [MIM 222100]), only four loci have ...
3. Genetic epidemiology of diabetes - all 3 versions »
MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig
Conventional genetic analysis focuses on the genes that account for specific
phenotypes, while traditional epidemiology is more concerned with the
environmental causes and risk factors related to traits. Genetic ...
4. Regulatory polymorphisms underlying complex disease traits - all 4 versions »
JC Knight - Journal of Molecular Medicine, 2005 - Springer
Abstract There is growing evidence that genetic variation plays an important
role in the determination of individual susceptibility to complex disease
traits. In contrast to coding sequence polymorphisms, where the ...
Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in
1,435 Multiplex Families - all 4 versions »
5. [PDF]
P Concannon, HA Erlich, C Julier, G Morahan, J … - DIABETES, 2005 - joslinresearch.org
Page 1. Original Article Type 1 Diabetes Evidence for Susceptibility Loci from Four
Genome-Wide Linkage Scans in 1,435 Multiplex Families Patrick Concannon, 1 Henry
A. Erlich, 2 Cecile Julier, 3 Grant Morahan, 4 Jørn Nerup, 5 ...
Cited by 45 - Related Articles - View as HTML - Web Search
32
6. Genetic susceptibility to type 1 diabetes - all 3 versions »
LM Maier, LS Wicker - Current Opinion in Immunology, 2005 - Elsevier
Type 1 diabetes (T1D) is a complex trait with both genetic and environmental
influences. T1D results from immune-mediated destruction of the
insulin-producing β cells of the pancreas. Autoimmune diabetes in the ...
7. T1DBase, a community web-based resource for type 1 diabetes research - all 7
versions »
LJ Smink, EM Helton, BC Healy, CC Cavnor, AC Lam, … - Nucleic Acids Research - Oxford Univ Press
T1DBase (http://T1DBase.org) is a public website and database that supports the
type 1 diabetes (T1D) research community. The site is currently focused on the
molecular genetics and biology of T1D susceptibility and pathogenesis. It ...
8. Genetic Approaches to Studying Common Diseases and Complex Traits - all 3
versions »
JN HIRSCHHORN - Pediatric Research, 2005 - IPRF
Most common diseases and most quantitative traits that can be measured in human
populations are complex genetic traits. That is, many genetic and nongenetic
factors interact to determine the final phenotype, whether that phenotype ...
9. Analysis of Multiple Data Sets Reveals No Association between the Insulin Gene
Variable Number … - all 5 versions »
BL Powell, L Haddad, A Bennett, N Gharani, U Sovio … - Journal of Clinical Endocrinology &
Metabolism, 2005 - Endocrine Soc
Context: Variation at the insulin gene VNTR (variable number tandem repeat)
minisatellite has been reported to be associated with polycystic ovary syndrome
(PCOS), but findings have been inconsistent and all studies have featured ...
10. Genetic insights into disease mechanisms of autoimmunity - all 4 versions »
MJ Simmonds, SCL Gough - British Medical Bulletin, 2005 - British Council
Educating the immune system to distinguish between self and non-self is critical
to ensure that an immune response is mounted against foreign antigens and not
against self. A breakdown in these mechanisms can lead to the onset of ...
TOTAL CITĂRI - 10
33
Eftychi C, Howson JMM, Barratt B, Vella A, Payne F, Smyth DJ, Twells RCJ, Walker
NM, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C,
Ionescu-Tîrgovişte C, Savage D, Todd JA. (2004) Analysis of the type 2 diabetes associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in
type 1 diabetes. Diabetes 53:870-873
Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1,
KCNJ11 … - all 4 versions »
C Eftychi, JMM Howson, BJ Barratt, A Vella, F … - Diabetes, 2004 - Am Diabetes Assoc
... Brief Genetics Report. Analysis of the Type 2 Diabetes-Associated Single Nucleotide
Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes. ...
1. Analysis of Separate and Combined Effects of Common Variation in KCNJ11 and PPARG on Risk of
Type 2 … - all 4 versions »
SK Hansen, EMD Nielsen, J Ek, G Andersen, C Glumer … - Journal of Clinical Endocrinology
& Metabolism, 2005 - Endocrine Soc
The separate and combined effects of the PPARG Pro 12 Ala polymorphism and the
KCNJ11 Glu 23 Lys polymorphisms on risk of type 2 diabetes were investigated in
relatively large-scale, case-control studies. Separate effects of the ...
2. IRS1, KCNJ11, PPARg2 and HNF-1a: do amino acid polymorphisms in these candidate genes support a
…
A Johansen, DP Jensen, R Bergholdt, HB Mortensen, … - Diabetes, Obesity and Metabolism,
2006 - ingentaconnect.com
Aims: Type 1 diabetes mellitus (T1DM) is a chronic disorder primarily triggered
by environmental and immunological factors in genetically susceptible
individuals. Despite the fact that there are indications of common ...
3. Association of Small Ubiquitin-Like Modifier 4 (SUMO4) Variant, Located in IDDM5 Locus, with
Type 2 … - all 3 versions »
S Noso, T Fujisawa, Y Kawabata, K Asano, Y … - Journal of Clinical Endocrinology &
Objective: Small ubiquitin-like modifier 4 (SUMO4) has been identified as a
candidate gene for the IDDM5 locus and suggested to have possible involvement in
immune responses, such as autoimmunity and inflammation. Recent reports ...
TOTAL CITĂRI - 3
34
Guja C, Guja L, Nutland S, Rance H, Sebastien M, Todd JA, Ionescu-Tirgoviste C.
(2004) Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania.
J Cell Mol Med 8:249-256.
Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania - all 3 versions »
C Guja, L Guja, S Nutland, H Rance, M Sebastien, … - J. Cell. Mol. Med, 2004 - Blackwell Synergy
Type 1 diabetes mellitus (T1DM) is a common autoimmune disease that arises (at
least in most of the cases) from the specific destruction of insulin secreting
pancreatic β cells by autoreactive T ... C. Guja a *, L. Guja a , S. ...
1. Contribution of Selective HLA-DRB1/DQB1 Alleles and Haplotypes to the Genetic Susceptibility of
Type … - all 5 versions »
FA Al-Jenaidi, SF Wakim-Ghorayeb, A Al-Abbasi, MR … - Journal of Clinical Endocrinology &
Context: Human leukocyte antigen (HLA) class II genes contribute to the genetic
susceptibility of type 1 diabetes (T1D), and both susceptible and protective
alleles were implicated with its pathogenesis, which varies among various ...
2. IL-18 gene promoter 137C/G and 607C/A polymorphisms in Chinese Han children with type 1 diabetes
GP Dong, ZS Yu, L Liang, CC Zou, JF Fu, CL Wang - International Journal of Immunogenetics, 2007 Blackwell Synergy
Skip to main content. ...
TOTAL CITĂRI - 2
35
Ionescu-Tîrgovişte C, Guja C, Călin A, Moţa M. (2004) An increasing trend in the
incidence of type 1 diabetes in children aged 0 – 14 years in Romania. Ten years (1988 –
1997) EURODIAB study experience. J Ped Endocrinol Metab 17:983-991.
An increasing trend in the incidence of type 1 diabetes mellitus in children aged 0-14
years in … - all 2 versions »
C Ionescu-Tirgoviste, C Guja, A Calin, M Mota - J Pediatr Endocrinol Metab, 2004 - ncbi.nlm.nih.gov
AIM: To assess the incidence of type 1 diabetes mellitus (DM1) in Romanian
children aged 0-14 years using EURODIAB Study methodology. METHODS: Data were
collected for a 10-year interval (1988-1997) for the whole country, using ...
1. Parasitic worms and inflammatory diseases - all 4 versions »
P Zaccone, Z Fehervari, JM PHILLIPS, DW DUNNE, A … - Parasite Immunol, 2006 - Blackwell
Synergy
The debate on whether infection precipitates or prevents autoimmunity remains a
contentious one. Recently the suggestion that some unknown microbe can be at the
origin of some chronic inflammatory diseases has been countered by ...
2. Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania - all 3 versions »
C Guja, L Guja, S Nutland, H Rance, M Sebastien, … - J. Cell. Mol. Med, 2004 - Blackwell Synergy
Type 1 diabetes mellitus (T1DM) is a common autoimmune disease that arises (at
least in most of the cases) from the specific destruction of insulin secreting
pancreatic β cells by autoreactive T ... C. Guja a *, L. Guja a , S. ...
3. Incidence and trends of childhood Type 1 diabetes in Croatia from 1995 to 2003
G Stipancic, L La Grasta Sabolic, M Malenica, A … - Diabetes Research and Clinical Practice, 2007 Elsevier
The incidence data were obtained from two sources. The incidence was calculated
as the number of newly diagnosed Type 1 diabetes patients per 100,000
person-years for the age group 0–14 years, and subgroups 0–4, 5–9, ...
Web Search
TOTAL CITĂRI - 3
36
Kyvik KO, Nystrom L, Gorus F, Songini M, Oestman J, Castell C, Green A, Guyrus E,
Ionescu-Tirgoviste C, McKinney PA, Michalkova D, Ostrauskas R, Raymond NT. (2004)
The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in
children. Diabetologia 47:377-384
The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children - all 5
versions »
KO Kyvik, L Nystrom, F Gorus, M Songini, J Oestman … - Diabetologia, 2004 - Springer
... incidence rates in The epidemiology of Type 1 diabetes mellitus is not the same
in young adults as in children 379 Table 1. Ascertainment ...
1. 1, 25-Dihydroxyvitamin D3 Modulates Expression of Chemokines and Cytokines in Pancreatic Islets: …
- all 5 versions »
CA Gysemans, AK Cardozo, H Callewaert, A Giulietti … - Endocrinology, 2005 - Endocrine Soc
1,25-Dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ) is an immune modulator that
prevents experimental autoimmune diseases. Receptors for 1,25-(OH) 2 D 3 are
present in pancreatic ß-cells, the target of an autoimmune assault in ...
2. The ‗accelerator hypothesis‘: relationship between weight, height, body mass index and age at … - all 2
versions »
I Knerr, J Wolf, T Reinehr, R Stachow, M Grabert, … - Diabetologia, 2005 - Springer
Page 1. Diabetologia (2005) 48: 2501–2504 DOI 10.1007/s00125-005-00332 SHORT COMMUNICATION I. Knerr . J. Wolf . T. Reinehr . R. Stachow .
M. Grabert . E. Schober . W. Rascher . RW Holl . on ...
3. Type 1 Diabetes and Latent Autoimmune Diabetes in Adults: One End of the Rainbow - all 4 versions »
RDG Leslie, R Williams, P Pozzilli - Journal of Clinical Endocrinology & Metabolism, 2006 Endocrine Soc
Context: The aim of this review was to explore the pathogenic and clinical
spectrum of type 1 diabetes, which includes a form of adult onset autoimmune
diabetes usually referred to as latent autoimmune diabetes in adults ...
4. Incidence of Type 1 and Type 2 Diabetes in Adults Aged 30-49 Years: The population-based registry in
G Bruno, C Runzo, P Cavallo-Perin, F Merletti, M … - Diabetes Care, 2005 - 0-intlcare.diabetesjournals.org.pugwash.lib.warwick.ac.uk
RESEARCH DESIGN AND METHODS—We extended the study base of the registry of the
province of Turin, Italy, to subjects aged 30–49 years in the period
1999–2001 to estimate the incidences of type 1 and type 2 diabetes. ...
5. A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes … - all 5
versions »
N Lammi, O Taskinen, E Moltchanova, IL Notkola, JG … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis The aim of this study was to examine the incidence and
trends of type 1 and type 2 diabetes in the 15–39 year-old population between
1992 and 1996 in Finland. Subjects and methods Data on the nationwide ...
37
6. Childhood type 1 diabetes mellitus in Newfoundland and Labrador, Canada - all 3 versions »
R Alaghehbandan, KD Collins, LA Newhook, D … - Diabetes Research and Clinical Practice, 2006 Elsevier
A total of 894 T1DM hospital separations among children aged 0–19 years were
identified, representing a hospitalization rate of 88.6 per 100,000 person-years
(PY). The CDMS identified 518 incidences of hospitalization (51.2 per ...
7. Seasonality of birth in children and young adults (0–29 years) with type 1 diabetes in Ukraine - all 6
versions »
AM Vaiserman, B Carstensen, VP Voitenko, MD Tronko … - Diabetologia, 2007 - Springer
Page 1. SHORT COMMUNICATION Seasonality of birth in children and young adults
(0–29 years) with type 1 diabetes in Ukraine AM Vaiserman & B. Carstensen & VP
Voitenko & MD Tronko & VI Kravchenko & MD Khalangot & LV Mechova ...
8. [PDF] Perspectives in Diabetes
RDG Leslie, MD Castelli - DIABETES, 2004 - scarlet.be
A decade ago we proposed that environmental factors operating in early life lead
to type 1 diabetes, outlining the evidence and the impli- cations if the
hypothesis was true (1). Today we can be confident that environmental ...
Related Articles - View as HTML - Web Search
9. The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15 …
DMR Rev - Diabetes Metab Res Rev, 2007 - doi.wiley.com
1 Diabetes Research Center, Free University Brussels, Belgium 2 Department of
Pediatrics, University of Antwerp, Antwerp, Belgium 3 Department of Pediatrics,
Paola Children‘s Hospital, Antwerp, Belgium 4 Department of Diabetology ...
10. The effect of birth order and parental age on the risk of type 1 and 2 diabetes among young adults - all 2
versions »
N Lammi, E Moltchanova, P Blomstedt, JG Eriksson, … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis The aim of this study was to examine the effects of
birth order and parental age on the risk of type 1 and type 2 diabetes among
Finnish individuals aged 15– 39 years. Methods Data on all cases of type ...
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Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RCJ, Green EA, Savage DA,
Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG.
(2004) Cost-effective analysis of candidate genes using htSNPs: a staged approach.
Genes and Immunity 5:301–305
Cost-effective analysis of candidate genes using htSNPs: a staged approach. - all 2
versions »
… Green, DA Savage, C Guja, C Ionescu-Tirgoviste, E … - Genes Immun, 2004 - ncbi.nlm.nih.gov
We have previously shown that the selection of haplotype tag single nucleotide
polymorphisms (htSNPs) and their statistical analysis in a multi-locus
transmission/disequilibrium test (TDT) results in a more cost-effective ...
1. Genome-wide association studies for common diseases and complex traits - all 10
versions »
2. Genome-wide association studies: theoretical and practical concerns - all 8 versions »
3. The Future of Association Studies: Gene-Based Analysis and Replication - all 5
versions »
BM Neale, PC Sham - The American Journal of Human Genetics, 2004 - UChicago Press
The past decade has seen a dramatic increase in the use of association studies
for the genetic analysis of complex disorders (Lander and Schork 1994; Risch
2000). The introduction of the transmission/disequilibrium test was one ...
4. Genetic association studies - all 5 versions »
HJ Cordell, DG Clayton - The Lancet, 2005 - Elsevier
We review the rationale behind and discuss methods of design and analysis of
genetic association studies. There are similarities between genetic association
studies and classic epidemiological studies of environmental risk factors ...
5. Population structure, differential bias and genomic control in a large-scale, casecontrol … - all 6 versions »
DG Clayton, NM Walker, DJ Smyth, R Pask, JD Cooper … - Nature Genetics, 2005 - nature.com
The results reported here concern the first phase of a study that will
eventually include 8,000 cases of type 1 diabetes (T1D; Genetic Resource
Investigating Diabetes study) 6, 7 and 8,000 controls drawn from the 1958 ...
39
6. Recent developments in genomewide association scans: a workshop summary and
review - all 5 versions »
DC Thomas, RW Haile, D Duggan - Am J Hum Genet, 2005 - UChicago Press
A traditional means of discovering disease genes begins with family-based
linkage scans, looking for regions of the genome that tend to be transmitted
through families in a manner that parallels the transmission of the trait, ...
7. Shaking the tree: mapping complex disease genes with linkage disequilibrium - all 3
versions »
LJ Palmer, LR Cardon - The Lancet, 2005 - Elsevier
Much effort and expense are being spent internationally to detect genetic
polymorphisms contributing to susceptibility to complex human disease.
Concomitantly, the technology for detecting and genotyping single ...
8. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag singlenucleotide … - all 5 versions »
9. Efficiency and consistency of haplotype tagging of dense SNP maps in multiple
samples - all 5 versions »
X Ke, C Durrant, AP Morris, S Hunt, DR Bentley, P … - Human Molecular Genetics, 2004 - Oxford
Univ Press
Haplotype tagging is a means of retaining most of the information in high
density marker maps, while reducing genotyping requirements. Estimates of the
numbers of tagging SNPs required to cover the human genome have varied ...
10 A comparison of tagging methods and their tagging space - all 4 versions »
X Ke, MM Miretti, J Broxholme, S Hunt, S Beck, DR … - Human Molecular Genetics, 2005 - Oxford
Univ Press
Single-nucleotide polymorphism (SNP) tagging is widely used as a way of saving
genotyping costs in association studies. A number of different tagging methods
have been developed to reduce the number of markers to be genotyped while ...
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Marre M, Puig JG, Kokot F, Fernandez M, Jermendy G, Opie L, Moyseev V, Scheen A,
Ionescu-Tirgoviste C, Saldanha MH, Halabe A, Williams B, Mion Junior D, Ruiz M,
Hermansen K, Tuomilehto J, Finizola B, Gallois Y, Amouyel P, Ollivier JP, Asmar R.
(2004) Equivalence of indapamide SR and enalapril on microalbuminuria reduction in
hypertensive patients with type 2 diabetes: the NESTOR Study. J Hypertens 22:16131622
Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients
M Marre, JG Puig, F Kokot, M Fernandez, G Jermendy … - J Hypertens, 2004 - jhypertension.com
... Equivalence of indapamide SR and enalapril on microalbuminuria reduction in
hypertensive patients with type 2 diabetes: The NESTOR* study. ...
1. Microalbuminuria and cardiovascular risk - all 4 versions »
J Karalliedde, G Viberti - American Journal of Hypertension, 2004 - Elsevier
Microalbuminuria is a marker for generalized vascular dysfunction. Its
prevalence in United States and European general population surveys ranges from
6% to 10%. Increased risk for cardiovascular morbidity and mortality begins ...
2. Evidence for renoprotection by blockade of the renin-angiotensin-aldosterone system in hypertension …
- all 5 versions »
J Karalliedde, G Viberti - J Hum Hypertens, 2006 - nature.com
The incidence of end-stage renal disease (ESRD) is rising worldwide, accompanied
by corresponding increases in the risk of morbidity and mortality. Underlying
this trend are increasing rates of hypertension and diabetes mellitus, the ...
3. Renal protection in hypertensive patients: selection of antihypertensive therapy - all 8 versions »
RR Wenzel - Drugs, 2005 - drugs.adisonline.com
Hypertension is common in chronic renal disease and is a risk factor for the
faster progression of renal damage, and reduction of blood pressure (BP) is an
efficient way of preventing or slowing the progression of this damage. ...
4. Diabetes mellitus and stroke - all 3 versions »
I Idris, GA Thomson, JC Sharma - Int J Clin Pract, 2006 - Blackwell Synergy
The combination of diabetes and stroke disease is a major cause of morbidity and
mortality worldwide. Evidence from large clinical trials performed in patients
with diabetes supports the need for aggressive and early intervention to ...
5. New concepts in blood pressure-lowering management in diabetic patients: the case for early ACE … all 6 versions »
CES Mogensen - J. Hum. Hypertens., 2005 - nature.com
Type II diabetes and the dysmetabolic syndrome are becoming more and more
prevalent, not only in the Western world, but also in many developing countries.
The key issue is early prevention and treatment, not only ...
6. An overview of the pharmacology and clinical efficacy of indapamide sustained release - all 3 versions »
J Sassard, A Bataillard, H McIntyre - Fundam Clin Pharmacol, 2005 - Blackwell Synergy
41
The relationship between blood pressure (BP) and cardiovascular risk is clearly
established; hypertension increases the rate of cardiovascular. High systolic
blood pressure (SBP) may be the main parameter involved in cardiovascular ...
7. Superior effect of an angiotensin-converting enzyme inhibitor over a diuretic for reducing aortic … - all
3 versions »
XJ Jiang, MF O‘Rourke, YQ Zhang, XY He, LS Liu - J Hypertens, 2007 - jhypertension.com
Background: In recent studies, benefit has been shown for angiotensin-converting
enzyme (ACE) inhibitors and calcium antagonists over a beta-blocker in
hypertension, through a greater reduction in aortic than brachial systolic ...
8. Efficacy of indapamide 1.5 mg, sustained release, in the lowering of systolic blood pressure - all 3
versions »
GM London - J Hum Hypertens, 2004 - nature.com
The aim of this review is to assess the efficacy of indapamide 1.5mg sustained
release (indapamide SR; brand names: Natrilix SR, Natrilix LP, Natrilix Retard,
Natrilix AP, Fludex LP, Fludex retard, Fludex SR, Fludex 1.5 mg, Tertensif ...
Cited by 4 - Related Articles - Cached - Web Search
9. Indapamide sustained release: a review of its use in the treatment of hypertension - all 7 versions »
DM Robinson, K Wellington - Drugs, 2006 - drugs.adisonline.com
In well controlled 12- to 52-week clinical trials, indapamide SR 1.5 mg/day was
well tolerated and reduced blood pressure as effectively as therapeutic dosages
of amlodipine, candesartan, enalapril, hydrochlorothiazide or indapamide ...
10. Efficacy of Indapamide SR Compared With Enalapril in Elderly Hypertensive Patients With Type 2 …
- all 3 versions »
JG Puig, M Marre, F Kokot, M Fernandez, G Jermendy … - American Journal of Hypertension, 2007 Elsevier
The urinary albumin-to-creatinine ratio decreased by 46% in the indapamide SR
group and 47% in the enalapril group. Noninferiority of indapamide SR over
enalapril was demonstrated (P = .0236; 35% limit of noninferiority) with a ...
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Nejentsev S, Cooper JD, Godfrey L, Howson JM, Rance H, Nutland S, Walker NM, Guja
C, Ionescu-Tirgoviste C, Savage DA, Undlien DE, Ronningen KS, Tuomilehto-Wolf E,
Tuomilehto J, Gillespie KM, Ring SM, Strachan DP, Widmer B, Dunger D, Todd JA.
(2004) Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.
Diabetes 53:2709-2712
Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes - all 3
versions »
… Howson, H Rance, S Nutland, NM Walker, C Guja, C … - Diabetes, 2004 - Am Diabetes Assoc
Vitamin D is known to modulate the immune system, and its administration has
been associated with reduced risk of type 1 diabetes. Vitamin D acts via its
receptor (VDR). Four single nucleotide polymorphisms (SNPs) of the VDR gene ...
1. Vitamin D and diabetes - all 4 versions »
C Mathieu, C Gysemans, A Giulietti, R Bouillon - Diabetologia, 2005 - Springer
Abstract Vitamin D deficiency predisposes individuals to type 1 and type 2
diabetes, and receptors for its activated form—1α,25-dihydroxyvitamin D 3
—have been identified in both beta cells and immune cells. Vitamin D ...
2. Vitamin D and type 1 diabetes mellitus: state of the art - all 5 versions »
C Mathieu, K Badenhoop - Trends in Endocrinology & Metabolism, 2005 - Elsevier
Recent evidence suggests a role for vitamin D in pathogenesis and prevention of
diabetes mellitus. Active vitamin D, 1α,25(OH) 2 D 3 , prevents type 1 diabetes
in animal models, modifies T-cell differentiation, modulates dendritic cell ...
3. Type 1 diabetes: pathogenesis and prevention - all 12 versions »
KM Gillespie - Canadian Medical Association Journal, 2006 - Can Med Assoc
Type 1 diabetes results from the autoimmune destruction of insulin-producing ß
cells in the pancreas. Genetic and, as yet undefined, environmental factors act
together to precipitate the disease. The excess mortality associated with ...
4. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. … all 3 versions »
AF Reis, OM Hauache, G Velho - Diabetes and Metabolism, 2005 - Elsevier
S UMMARY The Vitamin D endocrine system regulates multiple aspects of calcium
metabolism and cellular differentiation and replication in the immune system,
endocrine pancreas, liver, skeletal muscles and adi- pocytes. It plays an ...
5. Type 1 diabetes in Japan - all 3 versions »
E Kawasaki, N Matsuura, K Eguchi - Diabetologia, 2006 - Springer
Abstract Type 1 diabetes is a multifactorial disease which results from a
T-cell-mediated autoimmune destruction of the pancreatic beta cells in
genetically predisposed individuals. The risk for individuals of developing ...
6. Vitamin D receptor polymorphisms and diseases - all 3 versions »
JM Valdivielso, E Fernandez - Clinica Chimica Acta, 2006 - Elsevier
43
The vitamin D endocrine system is central to the control of bone and calcium
homeostasis. Thus, alterations in the vitamin D pathway lead to disturbances in
mineral metabolism. Furthermore, a role for vitamin D has been suggested in ...
7. Vitamin D Receptor Polymorphisms are Associated with Graves‘ Disease in German and Polish But not
E Ramos-Lopez, A Kurylowicz, T Bednarczuk, J … - THYROID, 2005 - liebertonline.com
THYROID Volume 15, Number 10, 2005 © Mary Ann Liebert, Inc. ... Elizabeth
Ramos-Lopez, 1 Alina Kurylowicz, 2 Tomasz Bednarczuk, 2 Jane Paunkovic, 3 ...
Christian Seidl, 4 and Klaus Badenhoop 1 ... Diverse genes are candidates ...
8. Protection From Type 1 Diabetes by Vitamin D Receptor Haplotypes - all 4 versions »
E RAMOS-LOPEZ, T JANSEN, V IVASKEVICIUS, H KAHLES, … - Annals of the New York
Academy of Sciences, 2006 - NYAS
Given the controversial association between polymorphisms within the VDR gene
and type 1 diabetes, we extended our previous report 9 of the polymorphisms Apa
I (rs7975232), Taq I (rs731236), Bsm I (rs1544410), and Fok I (rs10735810) ...
9. Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic
SW Guo, VL Magnuson, JJ Schiller, X Wang, Y Wu, S … - American Journal of Epidemiology, 2006 Oxford Univ Press
Several polymorphisms in the vitamin D receptor (VDR) gene have been reported to
be associated with the risk of developing type 1 diabetes, yet published
findings have been conflicting. In this study, the authors attempted to ...
10. Vitamin D and autoimmunity: new aetiological and therapeutic considerations - all 5 versions »
Y Arnson, H Amital, Y Shoenfeld - British Medical Journal, 2007 - ard.bmj.com
ABSTRACT Vitamin D is frequently prescribed by rheumatologists to prevent and
treat osteoporosis. Several observations have shown that vitamin D inhibits
proinflammatory processes by suppressing the enhanced activity of immune ...
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Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C,
Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J,
Newport MJ, Clayton DG, Todd JA. (2004) Comparative high-resolution analysis of
linkage disequilibrium and tag single nucleotide polymorphisms between populations in
the vitamin D receptor gene. Hum Mol Genet 13:1633-1639.
… high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms
between … - all 5 versions »
S Nejentsev, L Godfrey, H Snook, H Rance, S … - Human Molecular Genetics, 2004 - Oxford Univ Press
... Comparative high-resolution analysis of linkage disequilibrium and tag single
nucleotide polymorphisms between populations in the vitamin D receptor gene. ...
1. Genome-wide association studies: theoretical and practical concerns - all 8 versions »
2. Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Risk of Advanced Prostate Cancer - all 5
versions »
EM John, GG Schwartz, J Koo, D Van Den Berg, SA … - Cancer Research, 2005 - AACR
Substantial experimental evidence indicates that the hormonal form of vitamin D
promotes the differentiation and inhibits the proliferation, invasiveness, and
metastasis of human prostatic cancer cells. Results from epidemiologic ...
3. Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to … - all
8 versions »
AJH Genet - Am. J. Hum. Genet, 2005 - UChicago Press
The vitamin D receptor (VDR [MIM 601769]) (12q13) is a steroid receptor acting
as a transcription factor responding to the biologically active form of the
secosteroid vitamin D hormone. The vitamin D endocrine system is ...
4. Vitamin D and type 1 diabetes mellitus: state of the art - all 5 versions »
C Mathieu, K Badenhoop - Trends in Endocrinology & Metabolism, 2005 - Elsevier
Recent evidence suggests a role for vitamin D in pathogenesis and prevention of
diabetes mellitus. Active vitamin D, 1α,25(OH) 2 D 3 , prevents type 1 diabetes
in animal models, modifies T-cell differentiation, modulates dendritic cell ...
5. Molecular genetic studies of gene identification for osteoporosis: a 2004 update - all 3 versions »
YJ Liu, H Shen, P Xiao, DH Xiong, LH Li, RR Recker … - J Bone Miner Res, 2006 pubmedcentral.nih.gov
This review summarizes comprehensively the most important and representative
molecular genetics studies of gene identification for osteoporosis published up
to the end of December 2004. It is intended to constitute a sequential ...
45
6. Vitamin D receptor gene polymorphisms are linked to and associated with adult height - all 6 versions »
DH Xiong, FH Xu, PY Liu, H Shen, JR Long, L Elze, … - British Medical Journal, 2005 - jmg.bmj.com
Methods: We examined the relationship between VDR and adult height in 1873 white
subjects from 406 nuclear families. Four SNPs, namely –4817A/G at intron 1,
FokI C/T at exon 2 start codon, BsmI A/G at intron 8, and TaqI T/C at exon ...
7. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. … all 3 versions »
AF Reis, OM Hauache, G Velho - Diabetes and Metabolism, 2005 - Elsevier
S UMMARY The Vitamin D endocrine system regulates multiple aspects of calcium
metabolism and cellular differentiation and replication in the immune system,
endocrine pancreas, liver, skeletal muscles and adi- pocytes. It plays an ...
8. Association between a Protein Polymorphism in the Start Codon of the Vitamin D Receptor Gene and …
- all 5 versions »
MJ Taverna, JL Selam, G Slama - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine
Soc
Context: The vitamin D (VD) receptor (VDR) is extensively expressed in retina.
The plasma concentration of 1,25-dihydroxyvitamin D3 has been inversely
correlated with the severity of diabetic retinopathy (DR), which raises the ...
9. Vitamin D receptor polymorphisms and diseases - all 3 versions »
JM Valdivielso, E Fernandez - Clinica Chimica Acta, 2006 - Elsevier
The vitamin D endocrine system is central to the control of bone and calcium
homeostasis. Thus, alterations in the vitamin D pathway lead to disturbances in
mineral metabolism. Furthermore, a role for vitamin D has been suggested in ...
10. Fok I Polymorphism, Vitamin D Receptor, and Interleukin-1 Receptor Haplotypes Are Associated with
T Zemunik, V Skrabic, V Boraska, D Diklic, IM … - Journal of Molecular Diagnostics, 2005 - ASIP
Vitamin D and interleukin (IL)-1 have been suggested to function in the
pathogenesis of type 1 diabetes mellitus (T1DM). Therefore, we examined the
influence of gene polymorphisms in vitamin D receptor (VDR) and ...
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Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A,
Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tirgoviste C, Savage DA,
Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC,
Gough SC, Todd JA. (2004) Replication of an association between the lymphoid tyrosine
phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a
general autoimmunity locus. Diabetes 53:3020-3023.
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with
type … - all 2 versions »
D Smyth, JD Cooper, JE Collins, JM Heward, JA … - Diabetes, 2004 - ncbi.nlm.nih.gov
Click here to read Replication of an association between the lymphoid ... Smyth D, Cooper
JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S ...
1. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the
LA Criswell, KA Pfeiffer, RF Lum, B Gonzales, J … - Am J Hum Genet, 2005 - UChicago Press
Autoimmune diseases share a number of characteristics that suggest common
etiologic pathways or mechanisms, including reactivity to self-antigens by the
humoral and/or cellular immune system, as well as genetic associations with ...
2. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant - all 5 versions »
T Vang, M Congia, MD Macis, L Musumeci, V Orru, P … - Nat Genet, 2005 - nature.com
nature.com homepage Full text access provided to Googlebot Access by Web Services. ...
3. Protein tyrosine phosphatases and the immune response.
T Mustelin, T Vang, N Bottini - Nat Rev Immunol, 2005 - ncbi.nlm.nih.gov
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism
for numerous important aspects of eukaryotic physiology and is catalysed by
kinases and phosphatases. Together, cells of the immune system express at ...
4. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide … - all
5 versions »
5. Genetic epidemiology of diabetes - all 3 versions »
MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig
Conventional genetic analysis focuses on the genes that account for specific
phenotypes, while traditional epidemiology is more concerned with the
environmental causes and risk factors related to traits. Genetic ...
6. PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis - all 13
versions »
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VE Carlton, X Hu, AP Chokkalingam, SJ Schrodi, R … - Am J Hum Genet, 2005 - UChicago Press
Am. J. Hum. Genet., 77:567-581, 2005 0002-9297/2005/7704-0006$15.00 © 2005 by
The American Society of Human Genetics. All rights reserved. ... Received May
26, 2005; accepted for publication July 19, 2005; electronically published ...
7. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the … all 5 versions »
DJ Smyth, JD Cooper, R Bailey, S Field, O Burren, … - Nature genetics, 2006 - nature.com
1 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation
Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC
Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
8. [PDF] Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex
Families - all 4 versions »
P Concannon, HA Erlich, C Julier, G Morahan, J … - DIABETES, 2005 - joslinresearch.org
Page 1. Original Article Type 1 Diabetes Evidence for Susceptibility Loci from Four
Genome-Wide Linkage Scans in 1,435 Multiplex Families Patrick Concannon, 1 Henry
A. Erlich, 2 Cecile Julier, 3 Grant Morahan, 4 Jørn Nerup, 5 ...
Cited by 45 - Related Articles - View as HTML - Web Search
9. Association analysis of the 1858C> T polymorphism in the PTPN22 gene in juvenile idiopathic … - all 2
versions »
MK Viken, SS Amundsen, TK Kvien, KM Boberg, IM … - Genes and Immunity, 2005 - nature.com
A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene,
encoding a tyrosine phosphatase, has been reported to be associated with type I
diabetes and some other autoimmune diseases. To further investigate whether ...
10. Paths to understanding the genetic basis of autoimmune disease - all 6 versions »
JD Rioux, AK Abbas - Nature, 2005 - nature.com
Autoimmune diseases are major causes of morbidity and mortality throughout the
world. Many of these diseases tend to be difficult or impossible to cure, for
the obvious reason that the focus of the immune response — self antigens ...
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Vella A, Howson JMM, Barratt B, Twells RCJ, Rance H, Nutland S, Tuomilehto-Wolf E,
Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage D,
Todd JA. (2004) Lack of association of the Ala45Thr polymorphism and other common
variants of the NeuroD gene with type 1 diabetes. Diabetes 53:1158-1161
This article has been cited by other articles:
J. S. Szeszko, J. M.M. Howson, J. D. Cooper, N. M. Walker, R. C.J. Twells,
H. E. Stevens, S. L. Nutland, and J. A. Todd
Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1
Diabetes and Hardy-Weinberg Equilibrium Testing
Diabetes, February 1, 2006; 55(2): 559 - 562.
[Abstract] [Full Text] [PDF]
D. Smyth, J. D. Cooper, J. E. Collins, J. M. Heward, J. A. Franklyn, J. M.M.
Howson, A. Vella, S. Nutland, H. E. Rance, L. Maier, et al.
Replication of an Association Between the Lymphoid Tyrosine
Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and
Evidence for Its Role as a General Autoimmunity Locus
Diabetes, November 1, 2004; 53(11): 3020 - 3023.
[Abstract] [Full Text] [PDF]
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Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink
LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, Undlien DE,
Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Strachan DP, Peterson LB,
Todd JA, Wicker LS, Twells RC. (2005) Construction and analysis of tag single
nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type
1 diabetes. BMC Genet 6:9
Construction and analysis of tag single nucleotide polymorphism maps for six humanmouse orthologous … - all 8 versions »
… , S Nutland, DE Undlien, KS Rønningen, C Guja, C … - feedback, 2005 - biomedcentral.com
One strategy to help identify susceptibility genes for complex, multifactorial
diseases is to map disease loci in a representative animal model of the
disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 ...
Cited by 4 - Related Articles - Cached - Web Search
2. The autoimmune contrivance: Genetics in the mouse model - all 3 versions »
E Melanitou - Clinical Immunology, 2005 - Elsevier
Autoimmunity and inheritance of complex characters behold an explosive interest
in biology over the last 15 years. Research in the genetics of autoimmunity has
been impelled by the isolation of genetic markers allowing tracing of ...
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Payne F, Smyth DJ, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G,
Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE,
Ronningen KS, Guja C, Ionescu-Tirgoviste C, Todd JA, Twells RC. (2005) No evidence
for association of the TATA-box binding protein glutamine repeat sequence or the
flanking chromosome 6q27 region with type 1 diabetes. Biochem Biophys Res Commun.
331:435-41.
No evidence for association of the TATA-box binding protein glutamine repeat sequence
or the … - all 4 versions »
… , H Rance, DE Undlien, KS Rønningen, C Guja, C … - Biochemical and Biophysical Research
Communications, 2005 - Elsevier
Susceptibility to the autoimmune disease type 1 diabetes has been linked to
human chromosome 6q27 and, moreover, recently associated with one of the genes
in the region, TATA box-binding protein (TBP). Using a much larger sample ...
1. Fine mapping of genes within the IDDM8 region in rheumatoid arthritis - all 5 versions »
A Hinks, A Barton, S John, N Shephard, J … - Arthritis Research & Therapy 2006 - arthritisresearch.com
The IDDM8 region on chromosome 6q27, first identified as a susceptibility locus
for type 1 diabetes, has previously been linked and associated with rheumatoid
arthritis (RA). The region contains a number of potential candidate genes, ...
Related Articles - Cached - Web Search - BL Direct
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Pozzilli P, Manfrini S, Buzzetti R, Lampeter E, Leeuw ID, Iafusco D, Prisco M, IonescuTirgoviste C, Kolouskova S, Linn T, Ludvigsson J, Madacsy L, Mrozikiewicz AS,
Mrozikiewicz PM, Podar T, Vavrinec J, Vialettes B, Visalli N, Yilmaz T, Browne PD;
IMDIAB group. (2005) Glucose evaluation trial for remission (GETREM) in type 1
diabetes: a European multicentre study. Diabetes Res Clin Pract 68:258-264
Glucose evaluation trial for remission (GETREM) in type 1 diabetes: a European multicentre study all 3 versions »
P Pozzilli, S Manfrini, R Buzzetti, E Lampeter, ID … - Diabetes Research and Clinical Practice, 2005 Elsevier
... rights reserved. Glucose evaluation trial for remission (GETREM) in type
1 diabetes: a European multicentre study. P. Pozzilli a ...
1. Shorter Remission Period in Young Versus Older Children with Diabetes Mellitus Type - all 4 versions »
A Dost, A Herbst, K Kintzel, H Haberland, CL Roth, … - Exp Clin Endocrinol Diabetes, 2007 - thiemeconnect.com
Results: Partial remission (insulin <0.5 U/kg/d and HbA1c ≤7.0%) was present
in 1992 children (32.5%) within the first 3 months after diagnosis. Remission
phase lasted in average for 0.74±0.77 years and was significantly shorter ...
2. Immune intervention at diagnosis–should we treat children to preserve beta-cell function? - all 3 versions
»
J Ludvigsson - Pediatric Diabetes, 2007 - Blackwell Synergy
Abstract: Type 1 diabetes (T1D) is characterized by loss of beta-cell function.
If beta-cell function can be preserved, it will lead to improved metabolic
balance with improved quality of life and fewer acute and late ...
3. Dynamic changes in CD4+ CD25 high T cell apoptosis after the diagnosis of type 1 diabetes - all 2
versions »
S Glisic-Milosavljevic, T Wang, M Koppen, J Kramer … - Clinical & Experimental Immunology, 2007 ingentaconnect.com
S. Glisic-Milosavljevic,* T. Wang, † M. Koppen,* J. Kramer,* S. Ehlenbach,* J.
Waukau,* P. Jailwala,* S. Jana,* R. Alemzadeh ‡ and S. Ghosh* *The Max McGee
National Center for Juvenile Diabetes and Human Molecular Genetics Center, ...
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Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J,
Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE,
Ronningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.
(2005) Assessing the validity of the association between the SUMO4 M55V variant and
risk of type 1 diabetes. Nat Genet 37:110-111
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
- all 4 versions »
DJ Smyth, JMM Howson, CE Lowe, NM Walker, AC Lam, … - Nature Genetics, 2005 - nature.com
... this Correspondence. Assessing the validity of the association between the
SUMO4 M55V variant and risk of type 1 diabetes. Deborah J ...
1. [CITATION] Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag singlenucleotide … - all 4 versions »
3. Contribution of Single Nucleotide Polymorphisms within FCRL3 and MAP3K7IP2 to the Pathogenesis
of … - all 4 versions »
MJ Simmonds, JM Heward, J Carr-Smith, H Foxall, JA … - Journal of Clinical Endocrinology &
Context: Recently six DNA variants, two of which (M55V and 001Msp) are present
in nuclear factor- B inhibitors SUMO-4 and MAP3K7IP2 and four of which (fcrl3_3,
fcrl3_4, fcrl3_5, and fcrl3_6) modulate nuclear factor- B binding and ...
4. Genetic progress towards the molecular basis of autoimmunity - all 3 versions »
SHS Pearce, TR Merriman - Trends in Molecular Medicine, 2006 - Elsevier
The past few years have seen the identification of PTPN22 and the confirmation
of CTLA-4 as common autoimmune disease genes. Together with MHC and INS, these
developments have increased the collection of confirmed susceptibility loci ...
5. A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation - all 3 versions »
D Owerbach, EM McKay, ETH Yeh, KH Gabbay, KM … - Biochemical and Biophysical Research
Communications, 2005 - Elsevier
Four small ubiquitin-related modifier (SUMO) genes have been identified in
humans. However, little is known about the basic biology of SUMO-4. Here, we
report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation ...
6. The genetics of type 1 diabetes: Lessons learned and future challenges - all 3 versions »
53
S Onengut-Gumuscu, P Concannon - Journal of Autoimmunity, 2005 - Elsevier
Most investigators who study the genetics of T1D would generally agree that
there are at least four chromosomal regions for which there is compelling
evidence of a contribution to T1D risk, the HLA region on chromosome 6p21 ...
7. Evidence for the Role of Small Ubiquitin-Like Modifier 4 as a General Autoimmunity Locus in the … all 4 versions »
M Tsurumaru, E Kawasaki, H Ida, K Migita, A … - Journal of Clinical Endocrinology & Metabolism,
2006 - Endocrine Soc
Context: Recently, an association of a single nucleotide polymorphism, 163A>G
encoding M55V, in the gene SUMO4, which has been shown to be a negative feedback
regulator for nuclear factor B, has been reported in type 1 diabetes.
8. Genetics of Type 1 Diabetes: Similarities and Differences between Asian and Caucasian Populations - all
4 versions »
H IKEGAMI, T FUJISAWA, Y KAWABATA, S NOSO, T … - Annals of the New York Academy of
Sciences, 2006 - NYAS
Type 1 diabetes mellitus is caused by a complex interaction of genetic and
environmental factors. Genetic factor consists of multiple susceptibility genes
with a major locus encoded by HLA region on chromosome 6p21. 4–6 Class II ...
9. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to … - all
4 versions »
LJ Gibbons, W Thomson, E Zeggini, J Worthington, A … - Rheumatology, 2005 - Br Soc Rheumatology
Objectives. Linkage and association of rheumatoid arthritis (RA) and rheumatoid
factor (RF)-negative juvenile idiopathic arthritis (JIA) has previously been
demonstrated to the type 1 diabetes (T1D) locus, IDDM5, on chromosome 6q25. ...
10. Genetic and Functional Evidence Supporting SUMO4 as a Type 1 Diabetes Susceptibility Gene - all 4
versions »
CYI WANG, R PODOLSKY, JINX SHE - Annals of the New York Academy of Sciences, 2006 - NYAS
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by
specific destruction of the insulin-secreting beta cells of the pancreatic
islets. 1–3 It is believed that susceptibility to T1DM is determined by ...
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Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, Witte DR,
Fuller JH; EURODIAB Prospective Complications Study Group. (2005) Vascular risk
factors and diabetic neuropathy. N Engl J Med 2005 352:341-350
[CITATION] Vascular Risk Factors and Diabetic Neuropathy - all 7 versions »
S Tesfaye, N Chaturvedi, SEM Eaton, JD Ward, C … - New England Journal of Medicine, 2005
Original Article from The New England Journal of Medicine -- Vascular Risk Factors
and Diabetic Neuropathy. ... Vascular Risk Factors and Diabetic Neuropathy. ...
1. The 30-Year Natural History of Type 1 Diabetes Complications - all 7 versions »
G Pambianco, T Costacou, D Ellis, DJ Becker, R … - Diabetes, 2006 - Am Diabetes Assoc
Declining incidences in Europe of overt nephropathy, proliferative retinopathy,
and mortality in type 1 diabetes have recently been reported. However,
comparable data for the US and trend data for neuropathy and macrovascular ...
2. The changing epidemiology of diabetic microangiopathy in type 1 diabetes - all 3 versions »
P Rossing - Diabetologia, 2005 - Springer
Abstract Diabetic microvascular complications in the kidney and the eye are a
major burden for diabetic patients due to increased morbidity and mortality.
Furthermore, diabetic nephropathy is the leading cause of end-stage renal ...
3. Additional causes for distal sensory polyneuropathy in diabetic patients - all 5 versions »
KC Gorson, AH Ropper - British Medical Journal, 2006 - jnnp.bmj.com
Results: Fifty five patients (53%) had potential additional causes for DSP.
These included: neurotoxic medications (seven), alcohol abuse (six), and B12
deficiency and renal disease (four each). The most common laboratory ...
4. Effectiveness of frequency-modulated electromagnetic neural stimulation in the treatment of painful … all 4 versions »
E Bosi, M Conti, C Vermigli, G Cazzetta, E Peretti … - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: The largely unsatisfactory results reported for the
pharmacological treatment of diabetic neuropathy has spurred the search for
alternative therapies. The aim of this study was to evaluate the efficacy ...
5. Impact of Overweight on Chronic Microvascular Complications in Type 1 Diabetic Patients - all 6
versions »
CEM De Block, IH De Leeuw, LF Van Gaal - Diabetes Care, 2005 - 0-intlcare.diabetesjournals.org.pugwash.lib.warwick.ac.uk
RESEARCH DESIGN AND METHODS—A total of 592 type 1 diabetic patients without
nephropathy were studied (M/F: 324/268; age: 41 ± 12 years; duration: 19 ± 11
years; HbA 1c [A1C]: 7.9 ± 1.1%). Patients were subdivided according to ...
6. Early detection of diabetic peripheral neuropathy with corneal confocal microscopy - all 3 versions »
P Hossain, A Sachdev, RA Malik - The Lancet, 2005 - Elsevier
One could argue that corneal innervation has little clinical relevance to the
development of somatic neuropathy in diabetic patients. However, in animal
55
studies, corneal sensation is impaired within 3 months in both diabetic 14 ...
7. Diabetic neuropathy - all 6 versions »
V Bansal, J Kalita, UK Misra - British Medical Journal, 2006 - pmj.bmj.com
Diabetic neuropathy (DN) refers to symptoms and signs of neuropathy in a patient
with diabetes in whom other causes of neuropathy have been excluded. Distal
symmetrical neuropathy is the commonest accounting for 75% DN. Asymmetrical ...
8. Diabetic neuropathy is associated with activation of the TNF-alpha system in subjects with type 1 … - all
3 versions »
JM Gonzalez-Clemente, D Mauricio, C Richart, M … - Clin. Endo, 2005 - Blackwell Synergy
Results Thirty-six subjects had DN and 84 did not. Subjects with DN received
higher insulin doses (57·6 ± 16·7 vs. 49·2 ± 15·0 IU/day; P = 0·008) and
had higher WHR (0·85 ± 0·07 vs. 0·81 ± 0·10; P = 0·007) and HbA1c ...
9. Small fibre neuropathies - all 4 versions »
G Lauria - Curr Opin Neurol, 2005 - co-neurology.com
Recent findings: New causes of small fibre neuropathy have been recognized and
advances in neurophysiologic and neuropathologic techniques for investigating
small fibres have been made, increasing the interest in this field. In ...
10. Idiopathic neuropathy, prediabetes and the metabolic syndrome - all 2 versions »
A Gordon Smith, J Robinson Singleton - Journal of the Neurological Sciences, 2006 - Elsevier
Peripheral neuropathy is a common problem encountered by neurologists and
primary care physicians. While there are many causes for peripheral neuropathy,
none can be identified in a large percentage of patients (―idiopathic ...
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Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, IonescuTirgoviste C, Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA.
(2006) A genome-wide association study of nonsynonymous SNPs identifies a type 1
diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 38:617-619.
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes
locus in the … - all 5 versions »
… Burren, LJ Smink, C Guja, C Ionescu-Tirgoviste, B … - Nature genetics, 2006 - nature.com
1 Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation
Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC
Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.
1. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn …
- all 5 versions »
J Hampe, A Franke, P Rosenstiel, A Till, M Teuber, … - Nature Genetics, 2006 - nature.com
nature.com homepage Full text access provided to Googlebot Access by Web Services. ...
2. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a … all 2 versions »
A Elbaz, LM Nelson, H Payami, JPA Ioannidis, BK … - Lancet Neurology, 2006 - Elsevier
Investigators from three Michael J Fox Foundation for Parkinson's
Research-funded genetics consortia—comprising 14 teams—contributed DNA
samples from 5526 patients with Parkinson's disease and 6682 controls, ...
3. Genomic DNA pooling for whole-genome association scans in complex disease: empirical
demonstration … - all 4 versions »
S Steer, V Abkevich, A Gutin, HJ Cordell, KL … - Genes and Immunity, 2007 - nature.com
A pragmatic approach that balances the benefit of a whole-genome association
(WGA) experiment against the cost of individual genotyping is to use pooled
genomic DNA samples. We aimed to determine the feasibility of this approach ...
4. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis - all 3 versions
»
F Lundmark, K Duvefelt, E Iacobaeus, I Kockum, E … - Nat Genet, 2007 - nature.com
Multiple sclerosis is a chronic, often disabling, disease of the central nervous
system affecting more than 1 in 1,000 people in most western countries. The
inflammatory lesions typical of multiple sclerosis show autoimmune features ...
5. Genetic Mapping at 3-Kilobase Resolution Reveals Inositol 1, 4, 5-Triphosphate Receptor 3 as a Risk …
- all 3 versions »
SNP Typing - Am. J. Hum. Genet, 2006 - UChicago Press
Type 1 diabetes (T1D [MIM 222100]) is the most common chronic disease in
children and affects 1% of the population in high-incidence countries, such as
those of Scandinavia. The incidence of T1D is increasing worldwide by ...
6. Analysis of protein sequence and interaction data for candidate disease gene prediction - all 5 versions »
RA George, JY Liu, LL Feng, RJ Bryson-Richardson, … - Nucleic Acids Research, 2006 - Oxford Univ
57
Press
Linkage analysis is a successful procedure to associate diseases with specific
genomic regions. These regions are often large, containing hundreds of genes,
which make experimental methods employed to identify the disease gene ...
7. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene - all 4 versions »
H Hakonarson, SF Grant, JP Bradfield, L Marchand, … - Nature, 2007 - nature.com
Type 1 diabetes (T1D) in children results from autoimmune destruction of
pancreatic beta cells, leading to insufficient production of insulin 1 . A
number of genetic determinants of T1D have already been established through ...
8. Genomic Polymorphism at the Interferon-Induced Helicase (IFIH1) Locus Contributes to Graves'
Disease … - all 3 versions »
A Sutherland, J Davies, CJ Owen, S Vaikkakara, C … - Journal of Clinical Endocrinology &
Context: A recent large-scale analysis of nonsynonymous coding polymorphisms
showed strong evidence that an alanine to threonine amino acid change at codon
946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was ...
9. Family Based Studies and Genetic Epidemiology: Theory and Practice - all 2 versions »
JH Barrett, NA Sheehan, A Cox, J Worthington, C … - Hum Hered, 2007 - content.karger.com
Family studies have long played a central role in genetic epidemiology. Many
genes with a strong influence ondisease risk havebeen identified through linkage
studies. However the familial linkage approach has had a lim- ited ...
10. Recognition of viruses by innate immunity
O Takeuchi, S Akira - Immunological Reviews, 2007 - ingentaconnect.com
Summary: The innate immune system plays critical roles in recognizing viral
infections and evoking initial anti-viral responses. Nucleotides from RNA
viruses are recognized by retinoic acid-inducible gene I (RIG-I)-like ...
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Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev
S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JHM, Vella A,
Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink
LJ, Healy B, Burren OS, Lam AAC, Ovington NR, Allen J, Adlem E, Leung H-T,
Wallace C, Howson JMM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in
Finland, Simmonds MJ, Heward JM, Gough SCL, Dunger DB, the Wellcome Trust Case
Control Consortium, Wicker LS & Clayton DG. (2007) Robust associations of four new
chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39:857 –
864
[PDF] Robust associations of four new chromosome regions from genome-wide analyses of type 1
diabetes - all 2 versions »
JA Todd, NM Walker, JD Cooper, DJ Smyth, K Downes, … - Nat Genet, 2007 - nature.com
Page 1. Robust associations of four new chromosome regions from genome-wide
analyses of type 1 diabetes John A Todd 1 , Neil M Walker ...
Cited by 42 - Related Articles - View as HTML - Web Search - BL Direct
1. Guilt beyond a reasonable doubt - all 2 versions »
D Altshuler, M Daly - Nature Genetics, 2007 - nature.com
The Wellcome Trust Case Control Consortium (WTCCC) now reports in Nature the
largest GWAS thus far 1 , scanning 17,000 individuals for seven diseases, with
two follow-up studies reported in this issue, Todd et al. on type 1 ...
2. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene - all 4 versions »
H Hakonarson, SF Grant, JP Bradfield, L Marchand, … - Nature, 2007 - nature.com
Type 1 diabetes (T1D) in children results from autoimmune destruction of
pancreatic beta cells, leading to insufficient production of insulin 1 . A
number of genetic determinants of T1D have already been established through ...
3. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the
CE Lowe, JD Cooper, T Brusko, NM Walker, DJ Smyth, … - Nature Genetics, 2007 - nature.com
Genome-wide association studies are now identifying disease-associated
chromosome regions. However, even after convincing replication, the localization
of the causal variant(s) requires comprehensive resequencing, extensive ...
4. Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association
- all 7 versions »
JPT Higgins, J Little, JPA Ioannidis, MS Bray, TA … - American Journal of Epidemiology, 2007 Oxford Univ Press
Recent findings from genome-wide association studies have demonstrated their
considerable potential for identifying genetic determinants of common diseases
of public health significance such as cancer, heart disease, and diabetes ...
5. Genomics of Common Diseases
59
P Revill - Drug News Perspect, 2007 - journals.prous.com
There has been a recent spate of genome-wide association studies reporting new
associations between sequence variations on the human genome and common diseases
such as diabetes. These associations can lead to a better understanding of ...
Web Search
6. Commentary: Genetic association studies see light at the end of the tunnel - all 4 versions »
TM Frayling - International Journal of Epidemiology, 2007 - IEA
The authors‘ efforts are important for two main reasons. First, genetic
associations have been fraught with difficulty over the past 10 years in their
attempts to uncover DNA polymorphisms that alter disease risk. The vast ...
7. Allelic variant in CTLA4 alters T cell phosphorylation patterns
LM Maier, DE Anderson, PL De Jager, LS Wicker, DA … - Proceedings of the National Academy of
Sciences, 2007 - National Acad Sciences
Little is known regarding the functional effects of common autoimmune
susceptibility variants on human immune cells. The SNP CT60 (rs3087243; A/G)
located in the 3' UTR of the CTLA4 gene has been associated with autoimmune ...
Web Search
8. Genetic studies of diabetes following the advent of the genome-wide association study: where do we … all 3 versions »
TM Frayling, MI McCarthy - Diabetologia, 2007 - Springer
Page 1. COMMENTARY Genetic studies of diabetes following the advent of the
genome-wide association study: where do we go from here? TM Frayling & MI McCarthy
Published online: 25 September 2007 # Springer-Verlag 2007 ...
9. Genetic polymorphisms in susceptibility to Type 1 Diabetes - all 2 versions »
BZ Alizadeh, BPC Koeleman - Clinica Chimica Acta, 2007 - Elsevier
Type 1 Diabetes is a serious complex disease caused by several environmental and
genetic factors. It is one of most common childhood diseases, requires life-long
treatment, and is associated with increased mortality, mainly due to ...
10. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
S Nejentsev, JMM Howson, NM Walker, J Szeszko, SF … - Nature, 2007 - nature.com
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation
Laboratory, Department of Medical Genetics, Cambridge Institute for Medical
Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge ...
Web Search
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ANEXA 5.1
LISTA LUCRĂRILOR ÎN REVISTE
FĂRĂ COTAŢIE ISI
61
Anexa 5.1
ARTICOLE FULL TEXT ÎN REVISTE NEINDEXATE INTERNAŢIONAL
2003
1. Dobrin A, Bălan S, Nestorov M, Guja C, Burtea M, Ionescu-Tîrgovişte C, Heltianu C,
Simionescu M. (2003) Insertion/Deletion polymorphism of the angiotensinconverting enzyme gene in Romanian diabetic patients. Proc Rom Acad Series B
5(3):115-119, ISSN 1454-8267, Cod CNCSIS - 789
2. Mogos T, Bratu D, Panus C, Tanase I, Cheta D. (2003) Evaluation of the metabolic
balance in type 2 diabetes by assay of the hair glucose. Rom J Intern Med 41:61-65,
ISSN 1582-3296, NLM ID: 9304507
2004
3. Guja C, Guja L, Nutland S, Rance H, Todd JA, Ionescu-Tîrgovişte C. Strong
association of insulin gene INS -VNTR polymorphisms with type 1 diabetes in the
Romanian population. (2004) Rom J Intern Med 42:313-323, ISSN 1582-3296, NLM
ID: 9304507
4. Ionescu-Tîrgoviste C, Guja C, Ioacără S, Dumitrescu D, Tomescu I. (2004)
Continuous glucose monitoring: physiologic and pathophysiologic significance. Rom
J Intern Med 42:381-393, ISSN 1582-3296, NLM ID: 9304507
5. Ionescu-Tîrgovişte C, Gavrilă L, Brădescu OM, Guja C. (2004) New once-daily
intervention for type 2 diabetes mellitus: Diaprel MR. Rom J Intern Med 42:431-440
6. Lichiardopol R. (2004) Atypical antipsychotics and diabetes mellitus. Rom J Intern
Med 42:301-312, ISSN 1582-3296, NLM ID: 9304507
7. Mogos T, Vasilescu R, Lazar A, Stoica M, Bratu D. (2004) Proteic sulphur levels in
hair, possible tool to manage the balance of IDDM. Rom J Intern Med 42:441-445,
ISSN 1582-3296, NLM ID: 9304507
2005
8. Bradescu OM, Georgescu M, Ifrim S, Ioacara S, Ionescu-Tirgoviste C. (2005) Meal
testing and postprandial state of type 2 diabetic patients with metabolic syndrome.
Rom J Intern Med 43:97-113, ISSN 1582-3296, NLM ID: 9304507
9. Nwabudike LC, Ionescu-Tirgoviste C. (2005) Intradermal reactions to purified
protein derivative in patients with diabetes mellitus. Rom J Intern Med 43:127-132,
ISSN 1582-3296, NLM ID: 9304507
62
10. Margină D, Vlădică M, Grădinaru D, Mitrea N, Dănciulescu R, Radulian G. (2005)
Clinical study regarding the relationship between the inteleukin 6 level, insulin
resistance and endothelial dysfunction, Farmacia, Vol LII, 6, 2005, 18-24, ISSN
0014-8237, Cod CNCSIS 313
11. Margină D, Vlădică M, Dănciulescu R, Grădinaru D, Mitrea N. (2005) Clinical study
regarding the influence of hygieno-dietetic regimen on hyperglicemic overweight
patients. Archives of the Balkanic Medical Union 40, 3, 2005, 162-166, ISSN 00416940, Cod CNCSIS 391
2006
12. Botez G, Stancu C, Alexandru D, Vlădică M, Sima A. (2006) Glycated LDL induce
lipid loading in human smooth muscle cells, Proceedings of the Romanian Academy,
Series B 8:31-36, ISSN 1454-8267, Cod CNCSIS - 789
13. Cătană-Negreanu CI, Albu R, Glavce C, Vlădică M, Sima A. (2006) Apolipoprotein
E genotype in the romanian population - association with risk factors for metabolic
syndrome, Proceedings of the Romanian Academy Series B, (in press), ISSN 14548267, Cod CNCSIS - 789
14. Cojocaru M, Cheta N, Cheta DM, Cojocaru IM, Farcasiu E. (2006) The effect of
magnesium deficit on serum immunoglobulin concentrations in type 1 diabetes
mellitus. Rom J Intern Med 44:61-67, ISSN 1582-3296, NLM ID: 9304507
15. Margină D, Marin A, Mitrea N, Vlădică M, Dănciulescu R, Grădinaru D. (2006)
Evaluation of the intercellular adhesion molecule 1 (ICAM-1) as marker of the
endothelial dysfunction. Farmacia nr 3, vol LIV, 2006, 18-24, ISSN 0014-8237, Cod
CNCSIS 313
16. Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2006) Lipoproteins from
diabetic and hyperlipidemic patients induce an increase in scavenger receptors CD36
and LOX-1 gene expression in human endothelial cells, Proceedings of the Romanian
Academy, Series B 8:37-42, ISSN 1454-8267, Cod CNCSIS - 789
2007
17. Ioacara S, Cheta D. (2007) Cardiovascular risk factors in type 2 diabetes patients, in
the light of evidence-based medicine. Medicina Modernă Vol XIV, No. 1:6-10, Cod
CNCSIS - 475
18. Ioacara S, Sabau SV, Serafinceanu C, Ionescu-Tirgoviste C. (2007) The prospective
analysis of mortality in type 2 diabetes subjects in Bucharest, Romania. Proc Rom
Acad Series B, 2:141–148, ISSN 1454-8267, Cod CNCSIS - 789
19. Ionescu-Tirgoviste C, Guja C. (2007) Proinsulin, proamylin and the beta cell
endoplasmic reticulum: The key for the pathogenesis of different diabetes
phenotypes. Proc Rom Acad, Series B, 2:113–139, ISSN 1454-8267, Cod CNCSIS 789
63
20. Ionescu-Tîrgovişte C, Guja C. (2007) The various phenotypes of diabetes and the
endoplasmic reticulum of the beta cell. Rom J Intern Med 45:287-291, ISSN 15823296, NLM ID: 9304507
21. Popescu I, Dima S, Guja C, Gheorghe L, Iacob S, Hrehoreţ D, Matei E, Dorobanţu B,
Botea F, Sârbu V, Tulbure D, Ionescu-Tîrgovişte C. (2007) Combined liver and islet
transplantation using steroid-free immunossupression. Chirurgia (Bucur) 102:597602, Cod CNCSIS 392
64
ANEXA 5.2
LISTA COMUNICĂRILOR
65
Anexa 5.2
COMUNICĂRI LA CONGRESE INTERNAŢIONALE CU REZUMAT
PUBLICAT ÎN VOLUM DE REZUMATE
2003
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
Guja C, Marshall S, Welsh K, Todd J, Ionescu-Tîrgovişte C. (2003) The study of
Manose-Binding Lectin (MBL) polymorphisms in Romanian T1DM families.
Diabetes 52[Suppl 1]: A508 (Abstract)
NICOLAIE T, PREDA M, TIMOFTE D, MITRACHE M, HASSANAIN M,
CONSTANTIN C, COMAN A, GUTU D, VLADICA M, IOSUP A, PANAITE C,
BALAS B, POESINA N, CHETA D. (2003) The Vanadium Insulinmimetic Effect in
Discontinuous Administration. Diabetes 52[Suppl 1]: 2315-PO
NWABUDIKE LC, IONESCU-TIRGOVISTE C. (2003) Intradermal Reactions to
Purified Protein Derivative in Patients with Diabetes. Diabetes 52[Suppl 1]: 2290-PO
Bacanu E, Ionescu-Tirgoviste C. (2003) Microalbuminuria as marker of generalized
endothelial dysfunction. Diabetes Metab 29:4S351 (Abstract)
Burtea M, Cristescu J, Lichiardopol R, Ionescu-Tirgoviste C. (2003) Long term type
1 and type 2 diabetes: different patterns of chronic complications. Diabetes Metab
29:4S180 (Abstract)
Farcasiu E, Ionescu M, Simionescu C, Ionescu-Tirgoviste C. (2003) Epidemiology of
diabetes mellitus in Bucharest, 1996-1999. Diabetes Metab 29:4S9 (Abstract)
Georgescu O, Gavrila L, Soava L, Marin A, Ionescu-Tirgoviste C. (2003) Certain
aspects of asymmetry in diabetic retinopathy degree. Diabetes Metab
29:4S344(Abstract)
Guja C, Marshall S, Welsh K, Todd JA, Ionescu-Tîrgovişte C. (2003) No association
of TGF polymorphisms with T1DM genetic susceptibility in the Romanian
population. Diabetes Metab 29:4S43 (Abstract)
Lichiardopol R, Ionescu-Tîrgovişte C Apetrei E, Vlădică M, Kulcsar I, Guja C, Guja
L. (2003) Prevalence of glucose intolerance in a community-dwelling populational
group. Diabetes Metab 29:4S14 (Abstract)
Nwabudike LC, Ionescu-Tirgoviste C. (2003) Clinical characteristics of patients with
foot ulcers and diabetes mellitus. Diabetes Metab 29:4S287 (Abstract)
Pencea C, Sebestyen L, Savu O, Lichiardopol R, Ionescu-Tirgoviste C. (2003)
Comparative clinical profile in early vs. Late new diagnosed type 2 patients. Diabetes
Metab 29:4S180 (Abstract)
Perciun R, Costea M, Simionescu C, Ionescu-Tirgoviste C. (2003) Estimation of
well-being orally treated type 2 diabetic patients before and after 3 months from
insulin treatment start. Diabetes Metab 29:4S365 (Abstract)
Preda M, Gutu D, Nicolaie T, Iosup A, Hassanain M, Panaite C, Constantin C,
Coman A, Vladica M, Andronescu M, Timofte D, Balas B, Dimcevici-Poesina N,
Cheta D. (2003) Vanadium salts might induce islet proliferation in animal models.
Diabetes Metab 29:4S74 (Abstract)
Pruna S, Grigorescu M, Ionescu-Tirgoviste C. (2003) Diabetes control program by
using a data base management system. Diabetes Metab 29:4S402 (Abstract)
66
15. Radulian G, Vladica M, Panaite C. (2003) Efficacy of diet in obese patients with type
2 diabetes. Diabetes Metab 29:4S203 (Abstract)
16. Serafinceanu C, Pena CM, Mateiciuc SI, Asandei DT, Ionescu-Tirgoviste C. (2003)
Ferritin level has no relevance for clinic and biologic evolution of diabetic
hemodialysed patients. Diabetes Metab 29:4S302 (Abstract)
17. Brădescu O, Caceaune E, Ionescu-Tîrgovişte C. (2003) High incidence of peripheral
diabetic neuropathy in newly diagnosed older age type 2 diabetic patients associated
with early decrease of orthostatic blood pressure. NEURODIAB XIII, St Malo,
France, 30 August 2003
18. Ioacără S, Fărcaşiu E, Brădescu O, Guja C, Ionescu-Tîrgovişte C. (2003) Mortality in
type 1 diabetes patients with onset before age 40 years. Diabetologia 46[Suppl.
2]:A116 (Abstract)
19. Smyth D, Howson J, Twells R, Badhwar P, Walker N, Rance H, Barratt BJ, Savage
D, Carson D, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C,
Undlien D, Ronningen K, Stewart G, Todd JA. (2003) Identification of potential
therapeutic targets in complex diseases: evidence for protection from type1 diabetes
(T1D) by variants of CCR2 and CCR5. Am J Hum Genet 73:2146 (Abstract)
2004
20. CIMPONERIU D, COMAN A, APOSTOL P, RADU I, BALAS B, PANAITE C,
HARABA R, STAVARACHI M, GAVRILA L, PREDA M, CHETA D. (2004) The
IDDM2 and the Susceptibility to Type 1 Diabetes Mellitus (T1DM) in Romanian
Caucasian Population. A Case-Control Study. Diabetes 53[Suppl. 1]:2253-PO
21. NWABUDIKE LC, CORAVU DE, IONESCU-TIRGOVISTE C. (2004) Sensory
Testing in Peripheral Diabetic Neuropathy: A 616-Patient Study. Diabetes 53[Suppl.
1]:2249-PO
22. PANAITE C, COMAN A, GUTU D, BALAS B, CIMPONERIU D, NICOLAIE T,
CHETA D. (2004) The Influence of Silymarin on Diabetic Liver Disease in BB Rats.
Diabetes 53[Suppl. 1]:590-P
23. Vella A, Smyth D, Cooper JD, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE,
Ronningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Dunger DB, Strachan DP,
Ring SM, Todd JA. (2004) Convincing statistical support for association of the
Arg620Trp polymorphism in the PTPN22 locus with type 1 diabetes. Diabetes
53[Suppl. 1]:37-LB (Abstract)
24. Guja C, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Savage DA, Guja L, IonescuTîrgovişte C, Todd JA. (2004) Analysis of N Acetyl Transferase 2 gene variants in
type 1 diabetes. Diabetologia 47[Suppl. 1]:A133 (Abstract)
25. Guja L, Guja C, Ionescu-Tîrgovişte C, Nutland S, Todd JA. (2004) Strong association
of the insulin gene locus (IDDM2) with type 1 diabetes in the Romanian population.
Diabetologia 47[Suppl. 1]:A134 (Abstract)
26. Ioacără S, Fărcaşiu E, Brădescu O, Guja C, Scutaru G, Savu O, Ionescu-Tîrgovişte C.
(2004) Mortality in type 1 diabetes patients with onset after age 40 years.
Diabetologia 47[Suppl. 1]:A112 (Abstract)
67
27. Lichiardopol R, Niculescu N, Totora A, Pencea C, Ioacara S, Tomescu I, Cinteza M.
(2004) Hyperglycemia during acute myocardial infarction in diabetic and nondiabetic
patients. Diabetologia 47[Suppl. 1]:A430 (Abstract)
28. Pruna S, Ionescu-Tirgoviste C. (2004) A comparative study between color change
plaster for diabetic foot syndrome and electrical impedance change of plantar skin
sweat secretion. Diabetologia 47[Suppl. 1]:A376 (Abstract)
29. Radulian G, Vladica M, Panaite C, Balas B. (2004) The effects of hypocaloric and
hypolipidic diet on metabolic syndrome patients. Diabetologia 47[Suppl. 1]:A242
(Abstract)
30. Vella A, Smyth D, Cooper JD, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE,
Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Dunger DB, Strachan DP,
Ring SM, Todd JA. (2004) Convincing statistical support for association of the
Arg620Trp polymorphism in PTPN22 locus with type 1 diabetes. Diabetologia
47[Suppl. 1]:A133 (Abstract)
31. Ionescu-Tirgoviste C, Pruna S, Guja C, Ioacara S. (2004) Sympathetic sudomotor and
vasoconstrictor activity in type 1 and type 2 diabetic patients versus nondiabetic
subjects. Poster at the 14th Annual Meeting of the Diabetic Neuropathy Study Group
of the EASD NEURODIAB XIV, Joint symposium with the Diabetic Foot Study Group
of the EASD, Regensburg, Germany, September 2-5, 2004 (Abstract)
2005
32.
33.
34.
35.
36.
Radulian G, Constantin C, Rusu E. (2005) The effect of the educational program on
the lifestyle of obese patients with dyslipidemia and hypertension. ECO – the 14th
European Congress on Obesity, Athens, 2005 (Abstract)
Ioacara S, Ionescu-Tirgoviste C, Glavce C, Bojin A, Popa D. (2005) The prediction of
waist circumference from other variables using multiple regression analysis. Poster at
the 1st International Congress on "Prediabetes" and the Metabolic Syndrome,
Epidemiology, Management and Prevention of Diabetes and Cardiovascular Disease,
Berlin, Germany, April 13-16, 2005.
Ionescu-Tirgoviste C, Ioacara S, Caceaune E, Caceaune N, Guja C, Bojin A. (2005)
The waist circumference as a predictor of ultrasound hepatic dimensions in patients
with non-alcoholic fatty liver disease. Poster at the 1st International Congress on
"Prediabetes" and the Metabolic Syndrome, Epidemiology, Management and
Prevention of Diabetes and Cardiovascular Disease, Berlin, Germany, April 13-16,
2005.
Ionescu-Tirgoviste C, Ioacara S, Sabau S, Lichiardopol R, Guja C, Bojin A, Apetrei
E. (2005) Factor analysis of the risk variables of the insulin resistance syndrome in
Romania. Poster at the 1st International Congress on "Prediabetes" and the
Metabolic Syndrome, Epidemiology, Management and Prevention of Diabetes and
Cardiovascular Disease, Berlin, Germany, April 13-16, 2005.
BRADESCU O, GEORGESCU M, IOACARA S, IONESCU-TIRGOVISTE C.
(2005) Significance of C Reactive Protein in Postprandial State of Type 2 Diabetic
Patients with Metabolic Syndrome. Diabetes 54[Suppl. 1]: 668-P
68
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
CIMPONERIU D, SERAFINCEANU C, APOSTOL P, COMAN A, CRACIUN AM,
PANAITE C, CHETA DM. (2005) Could IDDM2 Influence the Development of
ESRD in T2DM? Diabetes 54[Suppl. 1]: 857-P
Guja C, Guja L, Ionescu-Tîrgovişte C. (2005) Genetic susceptibility – necessary for
T1DM occurrence in the Romanian population. Diabetes 54[Suppl. 1]: 1133-P
(Abstract)
Ioacără S, Ionescu-Tîrgovişte C, Guja C, Brădescu O, Scutaru G. (2005) KaplanMeier survival curves of type 1 diabetes mellitus patients with onset after 30 years.
Diabetes 54[Suppl. 1]:2431-PO (Abstract)
Ionescu-Tîrgovişte C, Apetrei E, Ioacără S, Lichiardopol R, Guja C, Vlădică M,
Culcsar I, Bojin A. (2005) Overweight is both a strong and early component in the
development of the metabolic syndrome. Diabetes 54[Suppl. 1]:1853-P (Abstract)
Nwabudike LC, Ionescu-Tîrgovişte C. (2005) Risk factors and clinical characteristics
for foot ulcers in patients with diabetes in Bucharest, Romania. Diabetes 54[Suppl.
1]:2489–PO
RADULIAN GN, CONSTANTIN C, PANAITE C. (2005) Adequacy Diet
Management for Metabolic Syndrome Patients. Diabetes 54[Suppl. 1]: 2739-PO
SERAFINCEANU C, CIMPONERIU D, CRACIUN AM., COMAN A, PANAITE C,
CHETA DM. (2005) The Vitamin D Receptor and ACE Gene Polymorphisms
Contribution to the Progression of Diabetic Nephropathy to End Stage Renal Disease
in Romanian Population. Diabetes 54[Suppl. 1]: 2284-PO
SERAFINCEANU C, STANCIU C, ENCULESCU DI, CHETA DM. (2005) Risk
Factors for Early Death on Hemodialysis in Diabetic Patients. Romanian 10-Year
Experience. Diabetes 54[Suppl. 1]: 2287-PO
Brădescu O, Georgescu M, Ioacără S, Ionescu-Tîrgovişte C. (2005) Presence Of
Peripheral Diabetic Neuropathy Associated With More Pronounced Features Of The
Metabolic Syndrome In Type 2 Diabetic Patients, poster la 15th Neurodiab Meeting,
Porto Heli, Greece, 8-10 September 2005
Radulian G, Rusu E, Constantin C. (2005) A low carbohydrate compared with a low
fat diet in elderly patients with type 2 diabetes mellitus. Diabetologia
48[Suppl1]:A269
Cătană-Negreanu C, Toma L, Albu R, Glavce C, Vlădică M, Sima A. (2005)
Apolipoprotein E genotype in the Romanian population - association with risk factors
for obesity. 3rd European Meeting on Vascular Biology and Medicine, Hamburg,
Germany, September 28 – 30, Journal of Vascular Research - Abstracts, vol. 42, p.
64, 2005.
Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2005) LDL from diabetic and
hypercholesterolemic patients induce an increase in scavenger receptors CD36 and
LOX-1 gene expression in human endothelial cells. 3rd European Meeting on
Vascular Biology and Medicine, Hamburg, Germany, September 28 – 30, Journal of
Vascular Research - Abstracts 2005.
Margină D, Vlădică M, Dănciulescu R, Grădinaru D, Mitrea N. (2005) Adiponectin
level and NO synthesis as atherogenic matkers at overweight and obese patients. Al
IV-lea Congres Naţional de Farmacie cu participare internaţională, Sofia, Bulgaria,
iunie 2005; publicată în volumul de rezumate ISSN 0428-0296
69
50.
51.
52.
53.
54.
55.
Margină D, Grădinaru D, Mitrea N, Vlădică M. (2005) Aspects regarding
hyperglycemic toxicity evaluated as redox stress parameters. 42nd Congress of
European Societies of Toxicology, 11-14 September, Cracow, Poland, Eurotox 2005,
publicată în volumul de rezumate, ISSN 0378-4274
for obesity. International One Day Symposium ―Combating Cardiovascular Diseases
and Diabetes‖, 14 October 2005, Bucharest
LOX-1 gene expression in human endothelial cells. International One Day
Symposium ―Combating Cardiovascular Diseases and Diabetes‖, 14 October 2005,
Bucharest
for obesity. International One Day Symposium “New Insights in Molecular
Medicine”, 4 November 2005, Bucharest
LOX-1 gene expression in human endothelial cells. International One Day
Symposium “New Insights in Molecular Medicine”, 4 November, 2005, Bucharest
Ioacara S. (2005) Hypoglicemia Evaluation Using Continuous Glucose Monitoring
System – Case Presentation. Oral presentation at the Salzburg Columbia Seminar in
Internal Medicine, Salzburg, Austria, June 28 – July 02, 2005.
2006
56.
57.
58.
59.
60.
61.
CIMPONERIU D, SERAFINCEANU C, APOSTOL P, CRACIUN AM, PANAITE
C, TOMA M, GAVRILA L, CHETA DM. (2006) Genetic Susceptibility for Diabetic
End Stage Renal Disease. Diabetes 55[Suppl. 1]:2177-PO (Abstract)
Guja C, Guja L, Ionescu-Tîrgovişte C, Nutland S, Stevens H, Todd JA. (2006) Effect
of HLA (IDDM1) and insulin gene (IDDM2) in type 1 diabetes patients and their
first-degree relatives in Romania. Diabetes 55[Suppl. 1]:1062-P (Abstract)
Ioacără S, Ionescu-Tîrgovişte C, Guja C, Bojin A. Mortality and causes of death in
oral treated type 2 diabetes mellitus patients. (2006) Diabetes 55[Suppl. 1]:913-P
(Abstract)
Ioacără S, Ionescu-Tîrgovişte C, Guja C, Bojin A. (2006) The prediction of waist
circumference in normal versus newly discovered type 2 diabetes patients. Diabetes
55[Suppl. 1]:2301-PO (Abstract)
Ionescu-Tîrgovişte C, Guja C, Vlădică M, Ioacără S, Bojin A, Filip I. (2006)
Proinsulin levels are significantly increased both in type 1 and type 2 diabetes
compared with normal subjects. Diabetes 55[Suppl. 1]:2473-PO (Abstract)
NWABUDIKE LC, CORAVU DE, IONESCU-TIRGOVISTE C, CRISTOFOR C.
(2006) Education Improves Awareness of the Diabetic Foot. Diabetes 55[Suppl.
1]:2352-PO (Abstract)
70
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
73.
74.
VLADICA M, MARGINA D, DANCIULESCU R, RADULIAN G, IOACARA S,
CHETA DM, IONESCU-TIRGOVISTE C. (2006) Inflammatory and Hormonal
Inflammatory and Hormonal Adipocytokines as Markers of Endothelial Dysfunction
as Markers of Endothelial Dysfunction. Diabetes 55[Suppl. 1]:2581-PO
Cimponeriu D, Ungureanu FD, Moldovan C, Apostol P, Serafinceanu C, Craciun
AM, Radu I, Stavarachi M, Mihai T, Usurelu D, Dan L, Cherry L, Dumitrescu L,
Gavrila L, Cheta DM. (2006) The MTHFR C677T polymorphism increases the risk
for ESRD in Romanian diabetic and nondiabetic patients. PP114. MOLECULAR
BASIS OF MONOGENIC AND COMPLEX DISEASES. 7th Balkan Meeting on
Human Genetics, BMHG, Skopje, Republica Macedonia, 31 august- 2 septembrie,
2006. (Abstract)
Cimponeriu D, Serafinceanu C, Apostol P, Usurelu D, Craciun AM, Panaite C,
Stavarachi M, Toma M, Gavrila L, Cheta D. (2006) Polymorphisms of some
candidate genes in diabetic nephropathy in Romanian population. European Journal
of Human Genetics, 14[Suppl 1]: 332 (Abstract)
DRAGAN S, MANCAS S, CHETA D, VELIMIROVICI D, RADA M, BARBU L,
OTIMAN G. (2006) Design of the met-antiox study: Synergic bioactivity of
antioxidant functional foods in the metabolic syndrome. Atherosclerosis Supplements
7:445 (Abstract)
Bugă C, Serafinceanu C, Pătraşcu T, Catrina E, Vâlcu M. (2006) Improving survival
in peritoneal dialysis - a surgeon perspective on peritonitis. Perit Dial Int
26[Suppl.2]:S46 (Abstract)
Constantin C, Radulian G, Rusu E. (2006) Role of glycemic index in a diet program
for type 2 diabetes obese patients. 10th International Congress on Obesity, Sydney,
2006 (Abstract)
Radulian G, Constantin C, Rusu E. (2006) Diet management for obese patients with
type 2 diabetes. 10th International Congress on Obesity, Sydney, 2006 (Abstract)
Bradescu O, Ioacara S, Ionescu-Tirgoviste C. Glycemic variability and chronic
complications in non-insulin-treated type 2 diabetic patients. Diabetic Med 23[Suppl.
4]:675 (Abstract)
Farcasiu E, Ioacara S, Florea R, Ionescu-Tirgoviste C. Changes of antihyperglycemic
therapy in adult patients for 2001-2005 period. Diabetic Med 23[Suppl. 4]:580
(Abstract)
Ioacără S, Ionescu-Tirgoviste C, Sabau S, Bradescu O, Guja C. (2006) Higher body
mass index at diagnosis is a protective factor for mortality in a prospective trial of
newly discovered type 2 diabetes patients. Diabetic Med 23[Suppl. 4]:178-179 Poster la 19th IDF Congress Cape Town, 3-7 December 2006
Ioacără S, Ionescu-Tîrgovişte C, Enachescu C, Guja C, Brădescu O. (2006) The Ideal
Waist Circumference - an emerging treatment target for abdominal obesity. Diabetic
Med 23[Suppl. 4]:582 - Poster la 19th IDF Congress Cape Town, 3-7 December 2006
Ionescu-Tirgoviste C, Guja C, Ioacara S, Vladica M. (2006) Plasma proinsulin could
be a marker of beta-cell dysfunction in both type 2 and type 1 diabetes. Diabetic Med
23[Suppl. 4]:66-67 (Abstract)
Ionescu-Tirgoviste C, Scaiceanu L, Ioacara S, Andrada B. Phenotypic particularities
in type 2 diabetes patients with retinopathy and/or nephropathy. Diabetic Med
23[Suppl. 4]:66-67 (Abstract)
71
75.
76.
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
87.
Radulian G, Rusu E, Margina D, Stoian M, Dragomir A, Constantin C. (2006)
Adequacy of glycemic and lipid management in people with type 2 diabetes. Diabetic
Med 23[Suppl. 4], IDF Congress, CapeTown 2006, (Abstract)
Rusu E, Radulian G, Vladica M, Margina D, Dragomir A, Constantin C. (2006)
Dietary change – an important role in people with metabolic syndrome. Diabetic Med
23[Suppl. 4], IDF Congress, CapeTown 2006, (Abstract)
Stoian M, Radulian G, Sotian B. (2006) Optimizing pre-ESRD care. III-rd World
Congress on „Quality in Clinical Practice‖, Thessaloniki, Greece, Sept. 2006,
(Abstract)
Cheta D, Radulian G, Constantin C. (2006) Romanian healthy nutrition foundation –
a real progress. The Ist World Congress of Public Health Nutrition, Barcelona, 2006,
(Abstract)
Cheta D, Dragomir A, Panaite C, Radulian G, Rusu E, Constantin C. (2006) Obesity
management: Practitioners point of view. The Ist World Congress of Public Health
Nutrition, Barcelona, 2006, (Abstract)
Constantin C, Rusu E, Radulian G, Cheta D. (2006) A nutritional program – Results
after 2 months of observation. The Ist World Congress of Public Health Nutrition,
Barcelona, 2006, (Abstract)
Panaite C, Dragomir A, Radulian G, Constantin C, Ion B, Cheta D. The Ist World
Congress of Public Health Nutrition, Barcelona, 2006, (Abstract)
Radulian G, Rusu E, Dragomir A. (2006) Diet management on metabolic syndrome
patients. The Ist World Congress of Public Health Nutrition, Barcelona, 2006,
(Abstract)
Constantin A, Vlădică M, Glavce C, Sima A, Popov D. (2006) Serum leptin levels
correlate with adiposity index, and not with the leptin receptor gene polymorphism,
Gln223Arg, in the Romanian population. Opening Workshop of CDRTU: ―Combating
Cardiovascular Disease and Diabetes‖, 27-29 April 2006, Bucharest, Abstract book,
p. 43
Margină D, Vlădică M, Mitrea N, Grădinaru D, Dănciulescu R. (2006) Evaluation of
the relationships between some parameters of the endothelial status and the body
mass index. International Opening Workshop of CDRTU ―Combating Cardiovascular
Disease and Diabetes‖, 27-29 April, 2006, Bucharest
Niculescu L, Baugé E, Vladică M, Fruchart-Najib J, Fruchart J-C, Sima A. (2006)
Distribution of the ApoA5 gene polymorphisms in a Romanian urban population.
Opening Workshop of CDRTU ―Combating Cardiovascular Disease and Diabetes‖,
27-29 April 2006, Bucharest, Abstract book, p. 46
Sima A, Cătană-Negreanu C, Albu R, Heltianu C, Vlădică M, Dorobanţu M. (2006)
Plenary lecture: Predictive value of apolipoprotein E genotype in obese patients with/
without CHD risk factors. International Opening Workshop of CDRTU ―Combating
Cardiovascular Disease and Diabetes‖, 27-29 April 2006, Bucharest, Abstract book,
p. 5
Stancu C, Botez G, Iordan A, Alexandru D, Vlădică M, Sima A. (2006) Plenary
lecture: Lipoproteins from obese patients induce an increase in scavenger receptors
CD36 and LOX-1 gene expression in human endothelial cells. Opening Workshop of
CDRTU: Combating Cardiovascular Disease and Diabetes, 27-29 April 2006,
Bucharest, Abstract book, p. 22
72
88.
89.
90.
91.
92.
93.
94.
95.
96.
97.
98.
Sima A, Cătană-Negreanu C, Albu R, Glavce C, Vlădică M. (2006) Plenary lecture:
Apolipoprotein E Polymorphism – A Genetic Marker for the Metabolic Syndrome.
One Day International Symposium ―Cell and Molecular Biology for the Benefit of
Cardiovascular Diseases‖, 8 June 2006, Iassy, Abstract book, p. 58
Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2006) Plenary lecture:
Lipoproteins from obese patients induce an increase in scavenger receptors CD36 and
LOX-1 gene expression in human endothelial cells. One Day International
Symposium ‖Cell and Molecular Biology for the Benefit of Cardiovascular
Diseases‖, 8 June 2006, Iassy, Abstract book, p. 61
Niculescu L, Baugé E, Vlădică M, Fruchart-Najib J, Fruchart J-C, Sima A. (2006)
Distribution of the ApoA5 gene polymorphisms in a Romanian urban population. The
2nd International Congress of Cellular and Molecular Biology, Iassy, 8-10 June 2006,
Abstract book, p. 47
Cătană-Negreanu C, Albu R, Glavce C, Vlădică M, Sima A. (2006) Apolipoprotein E
genotypes - a risk factor for obesity. XIVth International Symposium on
Atherosclerosis, 18-22 June 2006, Rome, Italy, Abstract book - Atherosclerosis
Suppl. Vol. 7, Issue 3, June 2006, p. 69
Stancu C, Botez G, Alexandru D, Vlădică M, Sima A. (2006) LDL from obese
patients induce an increase in scavenger receptors CD36 and LOX-1 gene expression
in human endothelial cells. XIVth International Symposium on Atherosclerosis, 18-22
June 2006, Rome, Italy, Abstract book, p. 415
Constantin A, Vlădică M, Glavce C, Sima A, Popov D. (2006) Serum leptin levels
correlate with adiposity index, and not with the leptin receptor gene polymorphism,
Gln223Arg, in the Romanian population. The International Symposium “Recent
Advances in Cardio-Diabetology“, Bucharest, 8 September 2006
Niculescu L, Baugé E, Vlădică M, Fruchart-Najib J, Fruchart J-C, Sima A. (2006)
Distribution of the APOA5 gene polymorphisms in a Romanian urban population.
The International Symposium “Recent Advances in Cardio-Diabetology”, Bucharest,
8 September 2006
Sima A, Albu R, Iordan A, Glavce C, Vlădică M. (2006) Apolipoprotein E genotype
in the Romanian population - association with risk factors for obesity. The
International Symposium “Recent Advances in Cardio-Diabetology”, Bucharest, 8
September 2006
Stancu C, Botez G, Iordan A, Alexandru D, Vlădică M, Sima A. (2006) LDL from
diabetic and hypercholesterolemic patients induce an increase in scavenger receptors
CD36 and LOX-1 gene expression in human endothelial cells. The International
Symposium “Recent Advances in Cardio-Diabetology“, Bucharest, 8 September 2006
Margină D, Mitrea N, Grădinaru D, Vlădică M. (2006) Clinical study regarding the
influence of thiazolidinediones on some parameters indicating the endothelial
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World Federation of Sleep Research and Sleep Medicine Societies, Cairns,
Australia 2–6 September 2007

Institutul Naţional de Diabet, Nutriţie şi Boli Metabolice "Prof. N. C.

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