Cri Du Chat

Cri Du Chat
(Cat's Cry Syndrome)
Lucas Rondenet, Ian Durden,
Claudio Ciardiello
What is Cri Du Chat?
• A rare chromosome disorder in which part of the fifth
chromosome is missing.
• 1 in 37,000-50,000 births are affected.
• Cri Du Chat is slightly more common in females.
• When an infant is born with Cri Du Chat, the infant cries
like a cat meowing.
Signs and Symptoms of Cri Du Chat
• The size of chromosome 5 depleted is related to how
severe mental retardation and development delay can be.
• Feeding problems
• Low birth weight
• Poor growth
• Severe cognitive, speech, and motor delays
• Hyperactive, aggressive, tantrums, and repetitive
movements
• Odd facial features
• Excessive dribbling
• May also be born with heart defects.
Kids with Cri Du Chat
Karyotype for Cri Du Chat
What Would My Child Look Like?
Physical Characteristics:
Parent 1: Parent 2:
Ian Durden Megan Fox
Brown Hair (BBCC): Brown Hair (BBcc)
BB= 2 Dominant Alleles for Brown Hair BB= 2 Dominant Alleles for Brown Hair
CC= 2 Dominant Alleles for Curly Hair cc= 2 Recessive Alleles for Straight Hair
Brown Skin Color (Bb): White Skin Color (bb)
Aa= Heterozygous for Brown Skin aa= 2 Recessive Alleles for White Skin
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• There is no specific treatment for this syndrome.
• This mental retardation must be addressed and can't
be avoided.
• Counseling is available and recommended for the
parents.
• Speech and physical therapy may be particularly useful
for children with CDC.
• Although it is rarely inherited to the offspring, parents
with family history of Cri Du Chat should consider
genetic counseling.
Punnett Squares
BC
Bc
Bc
a
A
BC
BBCc
BBCc
Brown/ Curly
Brown/ Curly
a
BBCc
BBCc
a
Brown/ Curly
Brown/ Curly
Aa
aa
Brown Skin
White Skin
Aa
aa
Brown Skin
White Skin
This boy has odd
facial features and
a small head. He
looks this way
because his fifth
chromosome is
lacking in size. His
father is black and
his mother is white,
therefore, he is
light skinned.
Links Used
• http://www.specialchild.com/archives/dz-012.html
• http://ghr.nlm.nih.gov/condition=criduchatsyndrome
• http://www.nlm.nih.gov/medlineplus/ency/article/0
01593.htm#Treatment
• http://www.wikipedia.org/
• http://www.blinn.edu/socialscience/LDThomas/feldman/
handouts/0203hand.htm
• http://www.google.com/