Barrier Packaging for Pharmaceuticals

PackAge 2011 CONFERENCE
A PRESENTATION ON
Barrier Packaging
g g of Pharmaceuticals
Focus
BLISTER PACKAGING
Benefits of a Blister Packs
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Convenient , easy to use and safe
Increases compliance and adherence
Easy to dispense
Product protection
Cost effective
Child resistant / Senior friendly
Improved Pharmacy efficiency
Alleviates space and inventory concerns
Other Benefits
Marketing Differentiation
• Compact clear blisters ensures product visibility
• Additional Branding on packs
• Pack Innovation e.g Burgo pack.Shell Pack,Calender pack
Shell pack
Burgo pack
Calender pack
World Pharmaceutical Packaging Demand
World Pharma
Blister Packaging
demand
1997
2002
2007
2012
2501
3545
4890
6590
Blister Packaging Film Types
• Thermoforming Films
• PVC
• PVC/PVdC
• PVC / Aclar
• APET , PET–G
• PP/COC/PP
• Barex
• Cold Forming Films
• OPA/ALU/PVC
• OPA / ALU/HSL ( tropical Blister)
Blister Packaging ClassificationBarrier
Low Barrier
• PVC
• APET , PET –G
• PP
• Medium Barrier
• PVC/PVdC
• COC
• High & Ultra High Barrier
• PVC / Aclar
• Cold Forming Foils
Blister Packaging Classification-Type
Halogen Free Films
• PP
• Barex ( PAN)
• PP/COC/PP
• APET , PET –G, GAG PET
New Generation Films
• Ultra High Barrier PVdC (Ultrsafe)
• Galaxy – (New Innovation by ACG)
• Alukbliss – ( Innovation by ACG)
PVC – Mono Layer Films
PVC – Poly Vinyl Chloride
Š Low Barrier Films suitable for stable molecules
Š Cost effective blister packaging option
Š Amorphous in nature
Š WVTR 3.5 g/m²/day
Š Calendered films available in range
g of colours
Š Long shelf life.
PVdC Coated PVC
PVC/PVdC
•Moderate
M d t O
Oxygen Barrier.
B i
•Range of barrier is available from
0.70-0.35 g
g/m²/day
y depend
p
on g
gsm
of coating.
PVC/PVdC/PVC
•Cross migration is low.
•No
N conveyer sticking.
ti ki
•No abrasion to PVdC coating.
PVC /PE /PVdC – Tripac Films
PVC / PE / PVdC - Tripac
Š Moderate
M d t M
Moisture
i t
B i
Barrier
Š The PE layer
improves Blister formation
Š Higher post forming barrier due to uniform thickness
on cavity
UltraSafe - Ultra High Barrier
New Generation PVdC Barrier Films
Š Ultra High Barrier properties
Š Available in 120 gsm
Š Suitable for Rotary and Flat Bed Blister Machines
Aclar - The Ultimate Barrier
Š Excellent barrier properties against
water
t vapor
Š Ideal for hygroscopic products
Š Improves strength and formation of
blister
Š Various PVC thickness and Aclar
grades give flexibility and desired
WVTR characteristic
PVC / Aclar - Laminates
Š Crystal clear packing
Š Chemically and bio-chemically inert
Š Extended Shelf Life
Š Design and Marketing Flexibility
Š Transparent to UV radiation
Š Non ageing
Š For High and Ultra-High moisture Barrier
Aclar – Range
Aclar Variant
Rx 160
Thickness in
Micron
WVTR
g/m²/day
(PVC/Aclar)
15 µm
0 41
0.41
20 µm
0.29
23 µm
0.23
51 µm
76 µm
102 µm
152 µm
0.15
0.07
0.05
Under development
Rx 20 e
SupRx 900
UltRx 2000
UltRx 3000
UltRx 4000
UltRx 6000
Aclar – Variants
Pet – G / Aclar
• PVC Free film
• Good Clarity
Aclar / EVOH / Aclar
• Oxygen and Moisture barrier
PVC / Aclar / PVC
• lower cross migration
• Lay flat blisters
• Lower abrasion to Aclar.
COLD FORM BASE FOILS
• Structure
OPA 25µ/Alu45µ/PVC60µ
• Ultra high barrier properties
• Suitable for all climatic zones
• Excellent delamination resistance
• DMF approved material
Tropical Blister
• Cold-formable
• It can withstand to low and high
te pe atu es
temperatures
• Typical lacquer sealing to: PVC, PVdC,PP
• High barrier to light
light, moisture
moisture, oxygen and
other gases
Non Halogenated films
(NON PVC OPTIONS)
Barex – Gas Barrier Films
Š Composite of Barex & Polypropylene
Composite of Barex & Polypropylene
Š Excellent Gas Barrier from Oxygen, Nitrogen, & Carbon Di id
Dioxide
Š Retains Aroma
Š High Impact Strength
Š High resistance to solvents & aggressive ‘hard to hold’ liquids
Š Thermoformable on conventional blister packing machines
Thermoformable on con entional blister packing machines
Š OTR is 105 cc/m2/day @ 25 Deg.C. & 100% RH
Barex
Features Š
Š
Š
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High impact strength
High
impact strength
Retains aroma
High resistant to solvents & aggressive “hard to hold” liquids.
E ll t
Excellent gas barrier from Oxygen, Nitrogen and Carbon
b i f
O
Nit
dC b
dioxide. Properties (Barex 250μ)
Š Density: 1.15g/cm
Density: 1 15g/cm³
Š MVTR(38⁰C,90%RH):3.5g/m²/day
Š OTR(23 ⁰C.100%RH):1.55cc/m²/day
PP/COC/PP
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High clarity
Density is 1
1.00
00 gm/cm3 hence higher yield
Thermoforming range is 120 to 160 Deg.C.
WVTR is
i 0.2
0 2 to
t 0.4
0 4 gm/m2/day
/ 2/d @38 Deg.C.
D C &
90 % RH
Polypropylene
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Thermoformable
FDA Compliant
Low density (0.9 gm/cm3) hence high yield
WVTR 1.15
1 15 gm/m2/day
/ 2/d @ 38 Deg.C.
D C & 90 %
RH
• OTR is 320 cc/m2/day @23 Deg.C.
Deg C & 100 %
RH
PETG films
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Excellent thermoformability
High gloss & superb clarity,
Sterlisable (Ethylene Oxide / Gamma radiation)
Excellent printability
MVTR is 14 to 16 gm/m2/day
PETG/ Aclar laminate provides excellent barrier
Made under license at Eastman Chemicals
APET based Films
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Eco-friendly material
o
o
Thermoforming range 121 C to 154 C
2
o
MVTR – 5.0 g /m / day
y at 38 C,, 90% RH
2
o
OTR – 10.0 cc/m / day at 23 C, 0% RH
Well suited for Filling & Sealing machines
machines.
Excellent printability
High clarity
Beyond Blister Packing
Unit Dose & Suppository Packing
PVC / PE – SUPPOS
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PVC/PE – SUPPOS are PVC / PE Laminates that are unique
Peelable/Sealable composites
•
U i
Uniquely
l sealable
l bl and
d peelable
l bl on any fform Fill seall liline
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Complete range of 100/30 to 300/ 50 PVC / PE available
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Proprietary PE allows effective sealing and easy peel
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For moisture sensitive suppository PVdC coated SUPPOS film also
available ( Typically 40 gsm)
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Available in Printed
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Random Printed
Register printed
Distortion Printed
Your trusted partner for Barrier Packaging Solutions
Overview ACG Pharmapack
Š A leading innovation-driven and world-class manufacturer
of all pharmaceutical barrier films
Š One-stop shop for all Pharma Barrier Packaging films.
Š DMF Registered
g
with the US FDA.
Š Registered with SFDA (China) & Canada Health Dept.
Š Exporter to more than 65 countries
Š Integrated Facility ensuring traceability
• ISO 9002 / 14001 / 22000 certified
Thank You