Syntor Fine Chemicals Presentation 2009

Overview

Independent, privately owned, growing company situated in the
North West of England.

We are a technical, competitive, and flexible company offering a product
range of Fine Chemical intermediates and Speciality Chemicals.

New products are initially developed from Syntor UK, with commercial
manufacturing capabilities in China and India. Product inventory available in
the UK

We offer a fully managed service tailored to companies needs:
Small scale process development
Multi-stage synthesis
 Large scale manufacture.
Development
Syntor have an experienced Technical
team in the UK working on new
process development, scale-up and
optimisation.
This operation supports our
manufacturing facilities in the UK,
China and India
Syntor UK, located close to Manchester
in the North West of England
Syntor (China) development laboratory
established in 2008, located in Hangzhou,
China.
This facility supports our UK Technical
team and provides a resource for process
optimisation and scale up activities , for
commercial production in China.
Hangzhou: Population 2.5m. Largest city
in Zhejiang province
Products
Main product groups:
Fine Chemicals / Intermediates:




Chloroalkylamine salts
Acid Chlorides
Friedel Crafts derivatives
Cyclopropyl derivatives
Intermediates supplied for a range of Pharmaceutical, Agrochemical and electronic
applications
Speciality products:
•
Boron Trichloride amine complexes
•
•
•
Acrylate monomers
Methacrylate monomers
Diallyamide monomers
(catalysts used as thermal initiators
during curing of epoxy resins)
Products are utilised in a range of polymer, surface coatings, electronics, catalysts,
adhesives, inks applications.
Manufacturing capabilities

2014 -

Flexible reactor sizes (100 litre – 15,000 litre)

Pilot facility

Multi purpose plants

Integrated Syntor Quality and Management Systems across all sites

Full QC/QA approval on-site

Syntor continues to invest in our manufacturing facilities/capabilities.

Established supply chain experience

ISO9001 standard
Expansion of Chinese production facilities to
provide increased scale and manufacturing capabilities.
Syntor locations in China
Map outlines Syntor facilities in China.
Facilities include R&D laboratories in Hangzhou
Pilot Plant operations and Commercial Manufacturing site in
Poyang, Jiangxi province.
China facility
Large commercial
manufacturing facility
New facility completion (Qtr 2 2014)
Wide range of GL reactors
Dedicated Friedel Crafts and Thionyl
Chloride units
Solids handling facility
Multipurpose units
Extensive distillation capabilities
Operating range -40C to 250C
Scale up capabilities
Clean area packaging facilities
Expanding facility
•Phase I – production of intermediates (Pharmaceutical, Agrochemical, Life
Science sectors)
•Phase II – production of specialty monomers and additional commercialised
projects which require specialist handling, eg. Grignard reactions
•Phase III – manufacture of advanced intermediates (cGMP).
Structure (China)
Syntor UK
Volant FC
66%
34%
Syntor
Hangzhou
Technology
49%
Volant FC
21%
2 x Private
investors
30%
Jiangxi
Wolan
Technology
Co. Ltd
Syntor Hangzhou Technology – development of new products
based in Hangzhou
Jiangxi Wolan Technology Co. Ltd – commercial manufacture
from new site in Poyang.
Syntor location in India
Well established joint venture facility with Shree Ganesh Group.
Purpose built plant utilising Syntor equipment and technology.
Situated approximately 300km north of Mumbai within a
developed industrial zone for Fine Chemical manufacture
India facility
Reactors
GL reactors 2,000 to 15,000 litres
SS Reactors 1,000 to 3,000 litres
3 x 2000 litre SS Hydrogenation reactors
(to 20bar)
4 x 250 litre GL reactors
Fully contained AHU solids handling and packing
facilities
Glass lined high vacuum distillation units
Operating range -15°C to 200°C
Centrifuges
Inert lined Filter dryers
Syntor Business Mix
- 80% of sales for export
- 60% of total sales supplied into Pharmaceutical sector
- 25% of sales turnover from Custom synthesis / Toll
manufacture
- 30% sales growth each year
Product Mix

Pharmaceutical
60%

Aroma
10%

Agrochemical
10%

Polymer
10%

Electronics
5%

Coating/Inks
5%
Pharma
Aroma
Photo/Reprographics
Electronic
Polymer
Agrochemical
What can Syntor offer?
Summary:
• Cost effective development and manufacturing options
• Flexible approach
• Wide range of Chemistry experience within Fine Chemicals and
Intermediates
• Products approved and stocked at COMAH and temperature
controlled storage facilities in the UK
• Fully managed service
Working with Syntor
Syntor can offer solutions to a number of requirements including:
• Develop products for early stage development projects
supported through to commercial supply
• Requirement for a second source of key intermediates
• Outsourcing partner for early stage intermediates
• Enable manufacture to take place in location where raw
material supply chain exists
Integrated Development
Br
COCl
CHO
OH
CO2H
Cl
Br
CO2R
CN
NH2
SO2Cl
CO2R
Cl
O
O
Summary of Reaction types
Alkylation
Esterification
Amination
Grignard
Chlorination
Hydrolysis
Condensation
Hydrogenation
Cyclisation
Dehydration
De-hydrochlorination
Methylation
Reduction
Main Product Groups
• Chloroalkylamine salts
• Boron trichloride derivatives
• Cyclopropyl derivatives
• Acryloyl Chloride derivatives
• Friedel Crafts derivatives
• Methacrylates
• Acid chlorides
• Alkene derivatives
• Diallylamide derivatives
Raw material handling
Bromo Chloro propane
Dimethyl Sulphide
Gamma butyryl lactone
Vitride
Thionyl Chloride
Hydrogen
Aluminium Chloride
Magnesium
Butyl Lithium
Allyl Alcohol
Sodium
Ammonia
Methacryloyl Chloride
Dimethyl amine
Featured range of Syntor Intermediates
utilised in synthesis of a range of API’s
Citalopram (Syntor
product: CAS 5407-04-5)
Naltrexone(Syntor
product: CAS: 705134-5
Methadone (Syntor product:
CAS:4584-49-0 & CAS: 8629-3)
Metopimazine (Syntor
product: CAS: 1771-18-2
Buprenorphine (Syntor product: Zilpaterol (Syntor product:
CAS: 7051-34-5
CAS: 3273-68-5
Featured Ester Synthesis
Conversion of ACH to HIBA to MHIBA
H3C
OH
CN
H3C
H3C
ACH
ACH = Acetone Cyanohydrin
HIBA = 2-Hydroxyisobutyric Acid
MHIBA = Methyl-2-hydroxyisobutyrate
OH
COOH
H3C
HIBA
H3C
OH
COOMe
H3C
MHIBA
Featured Chloroalkylamine salts
CH3
H3C
N
Cl
CH3
CH3
.HCl
Cl
N
H3C
N
H3C
Dimethylaminopropyl Chloride Hydrochloride (DMPC)
CAS no. : 5407-04-5
H3C
CH3
.HCl
Cl
Diisopropylaminoethyl Chloride
Hydrochloride (DIC)
CAS no. : 4261-68-1
Dimethylaminoethyl Chloride Hydrochloride (DMC)
CAS no. : 4584-46-7
.HCl
H3C
Cl
N
Cl
H3C
CH3
N
.HCl
H3C
Diethylaminoethyl Chloride Hydrochloride (DEC)
CAS no. : 869-24-9
CH3
Dimethylaminoisopropyl Chloride
Hydrochloride (DMC)
CAS no. : 4584-49-0
Featured Friedel-Crafts Derivatives
O
Cl
Cl
F
4-Chloro-4’-Fluorobutyrophenone (4C4FBP)
CAS no. : 3874-54-2
Trityl Chloride (TTC)
CAS no. : 76-83-5
N
O
C
Cl
F
F
2-Chloro-2’, 4’-Difluoroacetophenone (DFCAP)
CAS no. : 51336-94-8
Diphenyl Acetonitrile (DPAN)
CAS no. : 86-29-3
Featured Speciality monomer synthesis
Conversion of 3CPC to AC to Speciality Monomers
O
O
- HCl
Cl
Cl
Cl
AC
3CPC
3CPC = 3-Chloropropionyl Chloride
AC = Acryloyl Chloride
PGAc = Propargyl Acrylate
HFIPAc = Hexafluoroisopropyl Acrylate
O
O
PGAc
CF 3
F3C
O
O
HFIPAc
Featured Speciality Chemicals
Syntor range of monomers
Syntor have developed a range of monomers in conjunction with pre polymerisation techniques with Thermal
initiators eg. 2,2'-Azobis(2-methylbutyronitrile), plus photo initiators to produce a family of products that have
a wide number of properties/applications.
These products offer cost savings, and improved performance in relation to previous technologies.
Application areas are as UV activated adhesion promoters used in a wide range of industries (coatings,
adhesives, textiles, encapsulation)
O
O
N
N
N
N
O
O
O
N
CAS no: 1046789-74-5
CAS no: 39106-31-5
O
N
O
N
N
N
N
N
O
O
Code: SYN 1206
Code: SYN 1209
Featured Speciality Chemicals
Examples of monomers
O
n-Bu
O
+
N
N
N
N
+
N
SO3
-
2
Code: SYN 1328
Code: SYN 1325
N
N
O
O
O
N
O
N
O
N
O
N
Code: SYN 948
Code: SYN 1174
Code: SYN 1179
O
N
N
N
O
Code: SYN 1176
N
O
Code: SYN 956
Featured Speciality Chemicals
Epoxy resin curing agents
Cl CH3
Cl
B:
N
Cl CH3
CH3
Cl CH3
Boron Trichloride – Dimethyloctylamine Complex
CAS no. : 34762-90-8
Cl
B: N
CH3
Cl CH3
Boron Trichloride – Trimethylamine Complex
CAS no. : 1516-55-8
Products are predominantly used as latent curing agents for liquid
epoxy resins, or a latent accelerator for anhydride cured epoxy resins
Company Ethos

Provide transparent technical and costing information to all our
customers

Share the benefits of process improvements with our customers

Maintain confidentiality throughout, including intellectual property

Conduct business in a professional manner and with integrity
regarding every aspect of our business

Supply quality and reliable products and services

Develop long lasting customer relations
www.syntor.co.uk
Thank you for your time
Contacts
Managing Director
Simon Knowles
simon.knowles@syntor.co.uk
Technical Director
Dr David Reeves
david.reeves@syntor.co.uk
Commercial Director
Andrew Freer
andrew.freer@syntor.co.uk