PATHways - American College of Veterinary Pathologists
Transcription
PATHways - American College of Veterinary Pathologists
A J A N D O I N T T H E N S E W S L E T T E R O C I E T Y O F O F T H E A M E R I C A N C O L L E G E O X I C O L O G I C P A T H O L O G Y O F T V E T E R I N A R Y P A T H O L O G I S T S February, 2011 Volume 3, Issue 1 PAT H way s A newsletter for Students of Veterinary Pathology Welcome to PATHways! University is given by Gabrielle Pastenkos. Dr. Gaurav Tyagi from We haven’t had an issue of Roche Pharmaceuticals PATHways come out in a shares an interesting while, but plan on getting back case report of an abto our regular biannual scheddominal mass in a Cynoule. Once again, we have an molgus Macaque. We issue jam-packed with interestalso include a compreing information. Dr. Anoop hensive listing of upKavirayani from The Jackson coming veterinary paLaboratory contributed a very thology related events, nice article discussing mentorgeneral announcements of interest, and a ing from the mentees perspective. We have a nice biosketch detailing the duties of Dr. pictoral synopsis of the 2010 STP Annual Symposium Student Outing. Please be sure Stephanie Corn, a clinical pathologist for to check our pages 11 and 12 for some IDEXX Laboratories. An overview of the groups of interest on Facebook, and student ACVP chapter at The Ohio State Hello and welcome to the February 2011 issue of PATHways. We’re on the Web! www.toxpath.org www.acvp.org Did you know the STP website has an section dedicated solely to students? You can find information about membership, student opportunities and the NIH Loan Repayment Program. The STP is interested in hearing from students about how the student section of the website could be improved. Please check out the website by going to: http://www.toxpath.org and selecting “For Students” Please send any comments to Sue Pitsch at STP Headquarters (stp@toxpath.org) with “Student Website Feedback” as the subject. Page 12 for important information on awards that are available, as well as information on how to find a roomate, to help defray the cost of attending the 2011 STP Annual Symposium. Have fun reading the newsletter, and please don’t hesitate to let me know if you can think of a way to improve it, or if you have a contribution to make. I would love to include student contributions in the future! Your editor, Sarah Tannehill-Gregg Inside this issue: Mentoring: A Former Mentees Reflections 2-3 A Day in the Life Of…… Dr. Stephanie Corn 4 Focus on Our Future… The Ohio State University CVM Student ACVP Chapter 5-6 Case Report: The Case of the Mass-Laden Macaque 7-10 Announcements and Contact Information 11 Additional Items of Interest 12 A Litte Humor... 13 Upcoming Events 14 Fun at the STP Meeting! 15 If you would like to receive an electronic copy of PATHways, please send your e-mail address to Sarah TannehillGregg Volume 3 , I s s u e 1 Page 2 Mentoring: A former mentee’s reflections Contributed by Dr. Anoop Kavirayani, The Jackson Laboratory, Bar Harbor, Maine The teacher is the prior form, the taught is the poste- longer staples, but vital supplements. Instruction in rior form, learning is the intermediate form and Pathology as it happens becomes the staple. knowledge is the connection. Thus one should mediMentees can make the most of “instruction in Patholtate upon knowledge. (The Upanishads) ogy as it happens” by realizing that Pathologists vary Mentoring can be thought of as an augmentation of in their styles of practice and instruction. They will the learning process that results in the enrichment of a find great diversity in mentoring styles and outputs mentee’s knowledge in that discipline or pursuit. The and it is only natural that different styles and outputs mentee and mentor are integral components of such a will suit mentees of different aspirations and mindmentoring equation that consists of dynamic impartasets. As illustrated in the opening quote, the primary tion and imbibition of skill sets necessary for success focus should then be on the dynamic flow of knowlin professional practice. edge and sustained enrichment of skill sets. ReIn more specific terms, the Oxford Dictionary of Hu- sources and logistics permitting, mentees should try to develop mentoring relationships with multiple man Resource Management (© Oxford University mentors in different capacities. In addition to primary Press, 2010) defines mentoring as “the process, mentors, namely the Pathology faculty to whom the whereby a senior employee takes an active role in developing a junior colleague. Typically, this occurs mentees are assigned for the duration of the residency at managerial level or amongst professions. The men- program, it would be productive to have secondary and tertiary mentors. tor provides advice on how the mentee can develop his or her skills, competencies, knowledge, and experience in order to progress along a successful career path. As well as giving advice, the mentor might also prove useful in providing contacts that help the mentee to engage in the process of networking.” This definition seems to readily apply to Pathology training programs in which practicing Pathologists and Pathology educators facilitate in various ways, the favorable metamorphosis of students to Pathologists through the critical stage of residency. With the above perspective, it seems appropriate to reflect on the mentee side of the equation as applicable to Pathology mentoring. Once students transform to residents, they typically become units of a smaller, much more interconnected training group in which timed lectures and tailored laboratory sessions are no S J h g w a n , W y o m i n g a m e s P . B l a i r t t p : / / p h o t o g r a p h y . n a t i o n a l e o g r a p h i c . c o m Volume 3 , I s s u e 1 Page 3 Mentoring: A former mentee’s reflections, Cont. Secondary mentors would be visiting faculty or faculty at a collaborating institution with whom the mentees could interact periodically and primary mentors could facilitate such interactions. When feasible, mentees could also interact with tertiary mentors who would be members of organizations such as the American College of Veterinary Pathology, American Society of Investigative Pathology and Society of Toxicologic Pathology. Such interactions would typically be remote (electronic / telephonic) and should ensure that conflicts of interest are avoided. Annual and regional meetings could serve as venues of periodic follow-up on tertiary mentoring interactions. Through all these possibilities, mentees could prudently take it upon themselves to find the “intuitioninstruction equilibrium,” and assimilate and integrate as much as they can of the various styles and skill sets in line with their aspirations and long-term goals. I’ll now conclude my reflections and suggestions as a former mentee with the hope of transforming myself into a mentor. With a final note of gratitude to those who have mentored me in Pathology I wish all Pathology mentees-to-be the very best in finding productive “knowledge connections.” C o r m o r a n t J o s h E x e l l h t t p : / / p h o t o g r a p h y . n a t i o n a l g e o g r a p h i c . c o m “The capacity to blunder slightly is the real marvel of DNA. Without this special attribute, we would still be anaerobic bacteria and there would be no music” - Lewis Thomas (American physician, author of “The Lives of Cells: Notes of a Biology Watcher”) Volume 3 , I s s u e 1 Page 4 A day in the Life of…... Stephanie C. Corn, BS, DVM, Diplomate ACVP (Clinical Pathology) Who is your current employer? I am a clinical pathologist at IDEXX Laboratories, Inc. in Worthington, OH. Where did you do your training? 1992 – 1996, BS, Zoology, The Ohio State University 1996 – 2000, DVM, The Ohio State University 2002 – 2005, Clinical Pathology Residency , The Ohio State University 2005 – Diplomate, American College of Veterinary Pathologists I do consults with Veterinarians about results from cytology, hematology, or flow cytometry samples that I have evaluated as well as any other laboratory results that they need help interpreting. Our laboratory shares the building with a small animal specialty clinic (MedVet Medical and Cancer Center for Pets), and I train surgery, internal medicine, and oncology residents in pathology. I participate in tumor rounds with the specialists from MedVet. I also attend clinical pathology semiWhat are some of your day-to-day duties? nar with the clinical pathologists and clinical pathol I spend most of my time examining fine needle aspi- ogy residents at The Ohio State University. rate slides from a variety of lesions. Most of these are I train a clinical pathology resident that is in a skin or subcutaneous masses and peripheral lymph dual program with IDEXX and The Ohio State nodes, but I also see many ultrasound-guided aspirates University. of internal organs or masses. Most of the samples are from dogs and cats, but I also get samples from horses, What do you like most about veterinary paruminants, llamas/alpacas, exotics, and zoo animals. thology? Making a diagnosis in a tough case. It’s I evaluate fluid samples from the abdominal, pleural, very rewarding to be able to give the submitting Vetor pericardial space, as well as cerebrospinal fluid and erinarian a specific diagnosis that can guide treatjoint fluid. ment. My favorite cases are infectious diseases that I review abnormal blood smears flagged by technimimic neoplasia. It can be very hard to differentiate cians that perform the initial evaluation of CBC slides in between these based on the clinical presentation the lab. These patients may be diagnosed with leukemia, alone, and the treatment and prognosis are comblood parasites, or a specific etiology for their anemia pletely different. (e.g. Heinz body anemia). I interpret results of immunophenotyping by flow cytometry for dogs and cats with lymphocytosis in the peripheral blood. This can help differentiate between reactive lymphocytosis and lymphoid leukemia (chronic or acute). Lymph node samples from dogs diagnosed with lymphoma on cytology are also examined to differentiate between B-cell and T-cell lymphoma, which has prognostic value. Advice for students interested in veterinary pathology as a career? Learn about as many species as you can, and spend Vet school learning how to be a well-rounded Veterinarian. You can wait to specialize until your residency. Stephanie and Kira Volume 3 , I s s u e 1 Page 5 Focus on our Future…. Showcasing our Veterinary Schools and Pathology Programs tion to pathologic diagnosis of disease. These informal meetings are an excellent forum for general discussions about the profession. Formal lunch lectures are regular events, often hosted jointly with other clubs with the intention of demonstrating the interContributed by Gabrielle Pastenkos face of pathology and clinical medicine. Dr. Donald H. Schlafer, from Cornell College of Medicine, recently visited as a lecturer, at an event co-sponsored The Ohio State University College of Veterinary by the Pathology and Theriogeneology clubs. Dr. Medicine’s chapter of the ACVP was founded in Schlafer gave an engaging lecture on placental abnor2000. The club has a small core of dedicated members and maintains contact with a large portion of the malities. The club is looking forward to a lecture by student body through its listserv. Current officers are the College’s own Dr. Christopher Premanandan on ruminant abortion, co-hosted by the Food Animal Dillon Muth (President), Gabrielle Pastenkos (Vice Club. Dr. Premanandan’s food animal pathology lecPresident) and Amy Gagat (Treasurer). Dr. Paul D. Stromberg is faculty advisor, and Drs. Kristin Lewis tures are popular events. and Sarah Chaney are the 2010-2011 resident mentors. The club does not charge dues for membership Our professors and residents take an active role in and welcomes all students to its events. Our goal is directing students with specific interests in clinical that the majority of OSU veterinary students experi- and anatomic pathology towards shaping and achievence the interface of pathology and clinical medicine. ing their professional goals. A recent lecture featured Most events are made possible by the generosity of Dr. Krista La Perle ,Director of the Comparative Paour residents and professors, who freely share their thology and Mouse Phenotyping Shared Resource, time and expertise. Funds come from participation in discussing her professional history. Dr. Premanandan monthly Hills food sales in addition to grants from led several wetlabs that showed students how to sethe University. lect tissues from the necropsy floor for slide prepara- The Ohio State University College of Veterinary Medicine: Student Chapter of the ACVP The OSU SCACVP strives to provide experiential opportunities to students who are looking forward to clinical practice as well as to those planning on a career in pathology. Weekly slide readings with our residents keep pace with the first year histology curriculum, and club members run reviews before first year exams. Members of the pre-veterinary club join us for a wetlab where they get a hands-on introduc- G o s s L a b o r a t o r y tion. Students chose tissues, cut samples, fixed them and sent them for slide preparation, and participated in a slide review. Volume 3 , I s s u e 1 Page 6 Focus on our Future…. Showcasing our Veterinary Schools and Pathology Programs, Cont. The club makes a yearly presentation at the College’s open house program. The microscope lab is set up with slide cases, gross photos are displayed on a projector screen, and club members make themselves available to prospective students to answer questions both about the pathology field and veterinary school life in general. The club’s members take active roles in College research. Over the past two years, three members have participated in the College’s Summer Veterinary Scholar Research Program (supported both by an NIH T35 grant and the Morris Animal Foundation) and attended the Merck-Merial NIH National Veterinary Scholars Symposium to present their research. Dillon Muth’s project developed regulatory dendritic cells with the pregnancy estrogen Estriol. Gabrielle Pastenkos performed sequencing and phylogenetic analysis of three major surface antigens of Neorickettsia risticii. Bonnie Harrington’s project differentiated biologically high grade mast cell tumors from their biologically low grade counterparts based on molecular biology. Fourth year member Lauren Mattei received the OSU CVM 2010 Advances in Veterinary Medicine day basic research travel award for her poster, "Innate Immunity to Oral Salmonella Infection in Absence of IL-17." Club members attend the annual ACVP conference with financial assistance from the ACVP. At this year’s conference, Dillon Muth will be presenting a poster titled, “Synovial Cell Sarcoma in a Marmoset”. The club makes a yearly presentation at the College’s open house program. The microscope lab is set up with slide cases, gross photos are displayed on a projector screen, and club members make themselves available to prospective students to answer questions both about the pathology field and veterinary school life in general. The combination of outstanding pathology faculty, an excellent resident training program, and strong student interest facilitates exposure to a wide variety of practical pathology experiences for OSU students. V e t e r i n a r y M e d i c a l B u i l d i n g R e s e a r c h P o s t e r s A c a d e m i c o n D i s p l a y V o l u m e 3 , I s s u e 1 Page 7 Case Report The case of the Mass-Laden Macaque The presentation……………. Signalment: 10 year old, female, naive, cynomolgus macaque (Macaca fascicularis). History: On routine external examination, a mass was palpated in the caudal abdomen. Examination of a fine needle aspirate from the mass was non-specific and contained erythrocytes, hemosiderin-filled macrophages, and rare neutrophils. The animal was euthanized and necropsied. Clinical pathology (hematology, coagulation, routine clinical chemistry) identified a slightly decreased hematocrit (31%). Necropsy: The urogenital tract and colon/rectum were consolidated into a mottled, firm, irregular, approximately 4 x 4 x 5 cm mass that contained many blood filled cysts. Gross appearance of endometriosis in a human. The rectum is adherent to the left uterosacral ligament and the back of the cervix with endometriosis. (http://www.gynaecology.spotmysite.com/page/649/) Special thanks to Dr. Gaurav Tyagi, Senior Principal Scientist, Roche Pharmaceuticals, for contributing this case. V o l u m e 3 , I s s u e 1 Page 8 Case Report The case of the mass-Laden Macaque Subgross Appearance……………. * * * * Uterus 5000µm The perimetrial surface of the uterus was covered by variably sized cystic masses (*). Some of the cysts were filled with extravasated erythrocytes. V o l u m e 3 , I s s u e 1 Page 9 Case Report The case of the mass-Laden Macaque Microscopic Appearance……………. 200µm At higher magnification, the wall of the cysts was composed of ectopic endometrial tissue with epithelium, glands, and stroma. Histopathology: The outer surface of the uterus, ovary, broad ligament and colon were distorted and covered by many small coalescing cystic masses. The cysts were variably filled with erythrocytes, few neutrophils, macrophages and cellular debris and were lined by a single layer of well-differentiated glandular epithelium, morphologically consistent with endometrium. This epithelial layer was supported by spindleshaped endometrial stromal cells which merged into the adjoining smooth muscle or connective tissue. There were multiple interspersed areas of fibrosis expanded by chronic inflammation containing macrophages (some of them containing hemosiderin), lymphocytes and plasma cells. V o l u m e 3 , I s s u e 1 Case Report The case of the mass-Laden Macaque And the answer is……………. Microscopic diagnosis: Chronic endometriosis with adhesions Comments: Endometriosis is the ectopic growth of endometrial tissue, outside the uterus (Fanton et al., 1986). Endometriosis is a common disorder of sexually mature female macaques with a reported incidence of up to 30% in some colonies (Zondervan et al., 2004). Reported clinical signs in macaques with endometriosis are non-specific and include body weight loss, anorexia, constipation, decreased fertility and anemia. The masses in the abdominal and pelvic cavity can occasionally be palpated externally or by digital rectal examination. Grossly, endometriosis is often observed as mottled, tan, cystic masses in the pelvic and abdominal cavity over the surface of uterus, urinary bladder, distal colon and ovaries. Histologically, these masses are composed of ectopic endometrial glands and stroma with hemorrhage. This ectopic endometrial tissue undergoes cyclical changes in response to estrogen and progesterone, however the endometriotic lesions have been reported to have defective hormonal regulation (Sternfeld et al., 1988) Though an exact mechanism for the development of endometriosis is not known, it has been proposed that retrograde menstruation through the fallopian tubes causes the spread of endometrial tissue to the pelvic and peritoneal cavity (metastatic theory). Another hypothesis is that ectopic endometrium arises directly from the mesothelium of pelvis or abdomen (metaplastic theory). Risk factors for endometriosis reportedly include genetic predisposition, hysterectomy, whole body irradiation and exposure to toxins (Cline et al., 2008, Zondervan et al., 2004). Endometriosis is an important clinical condition of women and can cause infertility, pelvic pain and dysmenorrhea among other complications. Non human primates have been used as a model to investigate human endometriosis. References available on page 13. Page 10 V o l u m e 3 , I s s u e Page 11 1 References for Case Report Check out the ACVP Student Chapters group on Facebook! Cline, J.M., Wood, C.E., Vidal, J.D., Tarara, R.P., Buse, E., Weinbauer, G.F., de Rijk, E. & van Esch, E. (2008). Selected Background Findings and Interpretation of Common Lesions in the Female Reproductive System in Macaques. Toxicol Pathol, 36, 142164. Fanton, J.W., Hubbard, G.B. & Wood, D.H. (1986). Endometriosis: clinical and pathologic findings in 70 rhesus monkeys. American journal of veterinary research, 47, 1537-1541. Sternfeld, M.D., West, N.B. & Brenner, R.M. (1988). Immunocytochemistry of the estrogen receptor in spontaneous endometriosis in rhesus macaques. Fertility and sterility, 49, 342-348. Zondervan, K.T., Weeks, D.E., Colman, R., Cardon, L.R., Hadfield, R., Schleffler, J., Trainor, A.G., Coe, C.L., Kemnitz, J.W. & Kennedy, S.H. (2004). Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Human reproduction (Oxford, England), 19, 448-455. A m e r i c a n C o l l e g e V e t e r i n a r y P a t h o l o g i s t s o f S o c i e t y o f T o x i c o l o g i c P a t h o l o g y 2810 Crossroads Drive Suite 3800 Madison, Wisconsin 53718 1821 Michael Faraday Drive Suite 300 Reston, VA 20190 Phone: 608-443-2466 Fax: 608-442-2474 Email: membership@acvp.org Phone: 703-438-7508 Fax: 703-438-3113 Email: stp@toxpath.org http://www.facebook.com/#!/group.php?gid=1238795976443 10 This is a great site for student chapters to: Exchange ideas about meeting topics Get ideas for fundraising Look for housing for externships Find roommates for meetings Newsletter Committee Members Feel free to contact committee members with questions or for advice ACVP Recruiting Committee Student Chapter Subcommittee Chair: Brett Saladino (brett.saladino@covance.com) Newsletter Group: STP Career Outreach Committee Student Interactions Subcommittee Chair: Sarah Tannehill-Gregg (sarah.tannehill-gregg@bms.com) Newsletter Group: Krista La Perle (la-perle.1@osu.edu) Stephanie Corn* Sarah Tannehill-Gregg* (sarah.tannehill-gregg@bms.com) Lyn Wancket (stephanie-corn@idexx.com) Amanda Fales-Williams (afales@iastate.edu) (wancket.1@osu.edu) Chris Palgrave (chris_palgrave@ncsu.edu) Alok Sharma (alok.sharma@covance.com) Susan Van Tongeren (susan.vantongeren@boehringeringelheim.com) * Contributed to this newsletter V o l u m e 3 , I s s u e 1 Page 12 Additional Items of Interest…... STP Student Travel Awards Student Travel Awards are available to Graduate Students for participation in the Annual Symposium of the Society of Toxicologic Pathology. Each of the students who are chosen will receive a $1000 stipend to defray travel and lodging costs associated with attending the convention, complimentary meeting registration, and complimentary student membership (for the following year). Recipients will be honored at an Awards Ceremony prior to the Annual Business Meeting on Wednesday. Submit an abstract on-line by April 1, 2011, (should be limited to 250 words) describing your original work involving clinical or experimental research that relates to experimental or toxicologic pathology, at http://www.toxpath.org/ AM2011/awards.asp and please remember to fill out the Student Travel Award Flyer and Application. Additionally at http://www.toxpath.org/AM2011/awards.asp, please check out the information on the Young Investigator Awards and the Charles Capen Travel Award. More STP Fun!! There will be a student outing to the Denver Museum of Nature & Science on Tuesday afternoon, June 21. This will be a fun opportunity to meet fellow students and interact with mentors. This function has been the highlight of past meetings for many students. Details will be e-mailed to student registrants when available. See Page 15 for pictures of the 2010 Student Outing! Need Some Help with Housing at the STP Meeting? If you would like to save costs by sharing a room with another student at the 2011 Annual STP Meeting, please fill out the PDF found at http://www.toxpath.org/AM2011/housing.asp and return it to headquarters via fax (703.438.3113) or email by May 17, 2001 to the attention of Krystle Correll. Once we hear from other students, we will contact you with possible roomate contact information. Veterinary Pathology Residents on Facebook!! Group description: This group was created to foster communication between residents of both clinical and anatomic pathology programs. Gross, histology and cytology pictures can be posted to show classic/interesting/unusual diseases, lesions or simply to ask questions. This group can also be used to aid in board preparation and study, in which study materials can be shared. We will also institute a gross and/or histology/cytology picture of the month, and will accept submissions up to the 2nd to last Monday of every month. Please feel free to offer any comments or suggestions in order to make this group as beneficial for everyone possible. Go to Veterinary Pathology Residents (VPR): http://www.facebook.com/n/? home.php&sk=group_187061557991078&mid=3b4cf56G6063b467G204860dG7a&bcode=5lrV4&n_m=amycd% 40vet.upenn.edu V o l u m e 3 , I s s u e 1 Page 13 A Little Humor…... OK, so this one’s a joke (at least I hope so….), but I got a good laugh out of it! Pet Vet Barbie: Just what I wore to the office when I was in private practice – the ultra-short miniskirt and heels were so practical. Volume 3 , I s s u e 1 Page 14 Upcoming Events……………….. March 24-26, 2011 SAVMA Annual Symposium University of California, Davis June 19-23, 2011 30th Annual STP Symposium, Toxicologic Pathology of the Immune System. Davis, CA http://savmasymposium2011.com Hyatt Regency, Denver, CO April 9-13, 2011 http://www,toxpath.org/ American Society of Investigative Pathology (ASIP) Annual Meeting Washington, D.C. July 11-18, 2011 http://www,asip.org/ CL Davis Gross Pathology/General Pathology Review Course Sirata Beach Resort April 13-16, 2011 St. Pete’s Beach, FL CL Davis Workshop and Symposium on Laboratory Animal Diseases http://www,cldavis.org/ Chicago, IL http://www,cldavis.org/ April 21, 2011 July 25-29, 2011 Industrial Toxicology and Pathology CL Davis 28th Annual West Coast Subdivision Meeting University of Illinois Asilomar Conference Grounds, Champaign, IL Pacific Grove, CA http://www,vetmed.illinois.edu/ope/ itp ddanilen@gene.com May 18-20, 2011 3rd Annual Clinical Pathology Workshop for Pathology Residents August 11-12, 2011 Midwest Association of Veterinary Pathologists Annual Meeting Illinois Beach Resort and VA-MD Regional CVM Conference Center, Zion, IL Virginia Tech Student Chapter ACVP http://vetmed.illinois.edu/MAVP/ http://www.cpe.vt.edu/reg/cpaw/ May 23-27, 2011 CL Davis 2011 Descriptive August 21-25, 2011 Canadian Council on Animal Care Cornell University CVM 8th World Congress on Alternatives and Animal Use in the Life Sciences Ithaca, NY Montreal, Canada williams@cldavis.org http://www,wc8.ccac.ca Veterinary Pathology Course June 5-11, 2011 9th Biennial Short Course on Current Lab Animal Science Seminar/Pathology of Lab Animals Course Sheraton Oceanfront Hotel Virginia Beach, VA http://www,cldavis.org/ h t t p : / / w w w . s c o t t k r o e ke r . c o m / Sept 20-22, 2011 American College of Veterinary Pathologists Certifying Exam Ames, IA 2010 Society of Toxicologic Pathology Symposium Chicago, IL Student Outing to the Shedd Aquarium We hope to see you at the 2011 STP Symposium held June 19-23 in Denver, CO. We will have a student outing where you can spend the afternoon with STP members acting as mentors– it’s fun and informational! Special thanks to Krystle Correll for the beautiful pictures!