54th Annual Meeting - Parthenon Management Group

Transcription

54th Annual Meeting of the
American College of
Neuropsychopharmacology
Final Program
December 6-10, 2015
Diplomat Resort and Spa
Hollywood, Florida
President: Raquel E. Gur, M.D., Ph.D.
Program Committee Chair: Bita Moghaddam, Ph.D.
Program Committee Co-Chair: Carlos A. Zarate, M.D.
ACNP
AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY
54th
ANNUAL MEETING
GENERAL
PROGRAM
HOLLYWOOD, FLORIDA
DIPLOMAT RESORT & SPA
DECEMBER 6-10, 2015
Disclosures for 2015 speakers (mini-panel, panel, study group, and plenary) and
poster presenters may be found online at: www.acnp.org (click the Annual Meeting tab).
ACNP Annual Meeting Book 2015 rev13.indd 1
11/10/15 9:58 AM
ACNP 54th Annual Meeting • Final Program
2nd Floor Convention Center
GRAND
BALLROOM
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ATLANTIC
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SERVICE CORRIDOR
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CONVENTION
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Meeting rooms for panel, mini-panel, plenary, and study group sessions are on the 2nd
floor of the Convention Center (map above). An 8th concurrent session will be in Great
Hall 5-6 on the 3rd floor. Poster sessions and group lunches are also on the 3rd floor
(map below).
3rd Floor Convention Center
FREIGHT
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Resort, Second Floor
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Conference rooms for committee and board meetings are located on the 2nd and 3rd
floor of the hotel. Most small meetings have been scheduled on the hotel side.
Resort, Third Floor
NORTH
TOWER
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TOWER
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Program at a Glance
Saturday, December 5, 2015
8:00 AM - 3:00 PM
ACNP Council Meeting
Room 319-320
8:00 AM - 5:00 PM
Diplomat Ballroom 5
ACNP Membership Committee Meeting
9:00 AM - 5:00 PM
Atlantic Ballroom 1
NIAAA State-of-the-Science on Treating the
Comorbidity of Alcohol Use Disorders and PTSD
9:00 AM - 5:30 PM
CINP Executive Council Meeting
Room 321
Monday, December 7, 2015
Tuesday, December 8, 2015
7:00 AM - 8:00 AM
Room 216
ACNP Under-represented Minority Task Force
Meeting
7:00 AM - 8:30 AM
Room 322
CME Institute Executive Directors Meeting
7:00 AM - 8:00 AM
Diplomat Ballroom 5
ACNP Travel Awardee and Past Travel Awardee
Breakfast
7:30 AM - 9:30 AM
Morning Break
Grand Ballroom Foyer
8:00 AM - 11:30 AM
President’s Plenary
Grand Ballroom
10:30 AM - 4:30 PM
Poster Viewing
Great Hall 1-4
11:30 AM - 1:30 PM
Data Blitz
Regency Ballroom 2
Room 202
11:30 AM - 1:30 PM
Lunch
Great Hall 1-4
5:00 PM - 6:30 PM
Room 217
ACNP Publications Committee Meeting
1:30 PM - 3:00 PM
Distinguished Lecture
Grand Ballroom
6:30 PM - 8:30 PM
ACNP Travel Award Poster Reception
(by invitation)
2:30 PM - 4:30 PM
Afternoon Coffee Break
10:00 AM - 7:00 PM
Registration
3:00 PM - 5:00 PM
Room 217
Neuropsychopharmacology & Neuropsychopharmacology Reviews Editors Meeting
4:00 PM - 5:30 PM
ACNP Ethics Committee Meeting
Great Hall 2
7:00 AM - 8:30 AM
Room 201
ACNP Public Information Committee Meeting
7:30 AM - 9:30 AM
Morning Break
8:30 AM - 11:30 AM
Regency Ballroom 1-2
Neuropsychopharmacology Reviews
Plenary: Stress and Development: Molecular,
Neurobiological, and Genetic Approaches to
Understanding Pathology
11:30 AM - 1:00 PM
ACNP Past President’s Luncheon
Room 212/213
11:30 AM - 1:00 PM
Diplomat Ballroom 5
ACNP Program Committee Meeting
11:30 AM - 1:00 PM
Room 316
NIMH U19 Program Project–Duke–UNC–Pfizer
11:30 AM - 1:00 PM
Diplomat Ballroom 4
ACNP Liaison Committee Meeting
11:30 AM - 1:00 PM
Diplomat Ballroom 2
Neuropsychopharmacology Editorial Board Meeting
1:00 PM - 2:30 PM
Q & A Forum with NIH Institutes
2:30 PM - 4:30 PM
2:30 PM – 5:30 PM
Hot Topics
6:00 PM - 7:00 PM
ACNP Associate Member Reception
(by invitation)
7:00 PM - 9:00 PM
Opening Reception
3:00 PM - 5:30 PM
Diplomat Ballroom 1-2
The Molecular Pathology and Dynamics of Spine
Loss in Schizophrenia
3:00 PM - 5:30 PM
Regency Ballroom 3
A Multi-Modality Imaging Approach For The
Identification of Brain Biomarkers of Clinical
Outcomes in Human Addiction
3:00 PM - 5:30 PM
Regency Ballroom 2
Functional Neurogenomics in Schizophrenia:
Recent Accomplishments and Future Perspectives
3:00 PM - 5:30 PM
Atlantic Ballroom 1
Opportunities and Challenges for Buprenorphine in
Treating Depression
3:00 PM - 5:30 PM
Atlantic Ballroom 2
Going With Your Gut: Appetitive Hormones and the
Regulation of Substance Use
11:30 AM - 1:00 PM
Lunch on own
Room 220
Infinity Pool Deck
Monday, December 7, 2015
6:45 AM - 8:00 AM
CDI Booster Session
Room 212-213
7:00 AM - 6:00 PM
Registration
7:30 AM - 8:30 AM
ACNP & NIH Leadership Meeting
7:30 AM - 9:30 AM
Morning Break
Room 212-213
Mini Panel Sessions
8:30 AM - 9:45 AM
Regency Ballroom 1
Sharing is Caring: An Overview of the Data Sharing
Landscape
9:45 AM - 11:00 AM
Regency Ballroom 1
Brain-Wide ‘Glymphatic’ Pathway: Visualization
and Function
Panel Sessions
Panel Sessions
Sunday, December 6, 2015
7:00 AM - 7:00 PM
Registration
7:00 AM - 8:30 AM
Room 312-313
Under-represented Minority Breakfast
3:00 PM - 5:30 PM
Atlantic Ballroom 3
Extinction: New Directions from Basic Science to
Clinical Interventions
3:00 PM - 5:30 PM
Regency Ballroom 1
As Good as It Gets? New Insights From Genetic
and Circuitry-Based Models of OCD and Tourette
Syndrome
Study Group Session
3:00 PM - 5:30 PM
Great Hall 5-6
Reproducibility and Robustness of Experimental
Data in the Neurosciences - Opportunities for
Improvements
5:30 PM - 7:30 PM
Poster Session I with Reception
Great Hall 1-4
7:30 PM - 8:30 PM
Room 220
ACNP Under-represented Minority Task Force
Reception (by invitation)
7:00 AM - 6:00 PM
Registration
7:00 AM - 8:30 AM
Diplomat Ballroom 4
ACNP Education & Training Committee Meeting
7:00 AM - 8:30 AM
Room 201
ACNP Membership Advisory Task Force Meeting
7:00 AM - 8:30 AM
American Journal of Psychiatry
Editorial Board Meeting
Room 303
8:30 AM - 11:00 AM
Regency Ballroom 3
Behavioral Implications of Adult Neurogenesis and
Its Potential as Treatment Target
8:30 AM - 11:00 AM
Regency Ballroom 2
The Role of Epigenetic Mechanisms in the
Transition into Alcohol Addiction
8:30 AM - 11:00 AM
Atlantic Ballroom 1
From Animals to Humans: The Role of
Neuroinflammation in Psychosis and
Psychosis Risk
8:30 AM - 11:00 AM
Atlantic Ballroom 2
Genetic Approaches to Delay Discounting: Human
and Non-Human Animal Approaches
8:30 AM - 11:00 AM
Atlantic Ballroom 3
The Road to Recovery: Delineating the Neural
Circuits of Compulsive Drug Use
Study Group Sessions
8:30 AM - 11:00 AM
The Future of Sex Difference Research in
8:30 AM - 11:00 AM
Great Hall 5-6
rt-fMRI Neurofeedback: Are We There Yet?
10:30 AM - 4:30 PM
Poster Viewing
Great Hall 1-4
11:00 AM - 1:00 PM
Women’s Luncheon
Grand Ballroom
11:00 AM - 12:30 PM
Lunch
Great Hall 1-4
12:30 PM - 1:30 PM
PMG Board Meeting
Room 209
1:30 PM - 3:00 PM
Regency Ballroom 1
Career Development Session
2:30 PM - 4:30 PM
Mini Panel Sessions
3:00 PM - 4:15 PM
Regency Ballroom 1
Social (Cognitive) Functioning in Schizophrenia:
Course, Mechanisms, and Treatment
4:15 PM - 5:30 PM
Regency Ballroom 1
Neuropsychiatric Disorders in Isolated Populations
Panel Sessions
3:00 PM - 5:30 PM
Signals From the 4th Dimension: How the
Extracellular Matrix Regulates Synaptic Plasticity
and Neuropsychiatric Disease
3:00 PM - 5:30 PM
Regency Ballroom 3
Neuroimaging, Addiction and Big Data:
Opportunities and Challenges
iv
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Program at a Glance
Wednesday, December 9, 2015
3:00 PM - 5:30 PM
Regency Ballroom 2
Schizophrenia as a “Dysplasticity” Disorder
8:30 AM - 11:00 AM
Atlantic Ballroom 3
Mining a Genomic Hotspot for Psychosis:
Mechanistic Insights from 22q11.2 Microdeletions
3:00 PM - 5:30 PM
Atlantic Ballroom 1
Inflammation-Induced Modulation of Motivation:
Impact on Neurotransmitters and Neurocircuits
3:00 PM - 5:30 PM
Atlantic Ballroom 2
Molecular Mechanisms Underlying
Psychopathology and Treatments in OCD
3:00 PM - 5:30 PM
Atlantic Ballroom 3
Research Paradigms and Non-Pharmacological
Interventions Aimed to Prevent the Onset and
Progression of Bipolar Disorder in Children
Study Group Session
3:00 PM - 5:30PM
Great Hall 5-6
Training Aspects of International Research
Collaborations: Experiences from Multinational
Initiatives in Biological Psychiatry Between the
USA, Europe, Asia, and Africa
5:30 PM - 7:30 PM
Poster Session II with Reception
Great Hall 1-4
6:00 PM - 11:00 PM
Room 319-320
ACNP Council Meeting – Committee Chair Reports
6:00 PM - 11:00 PM
Room 318
ACNP Committee Chairs Waiting Room
Wednesday, December 9, 2015
6:45 AM - 8:30 AM
ASCP Board of Directors Meeting
6:45 AM - 8:00 AM
CDI Booster Session
Room 201
Room 212-213
7:00 AM - 8:30 AM
Diplomat Ballroom 4
SOBP Program Committee Meeting
7:00 AM - 8:00 AM
Room 216
MD & MD/PhD Travel Awardee Roundtable
(by invitation)
7:30 AM - 5:30 PM
Registration
7:30 AM - 9:30 AM
Morning Break
Mini Panel Sessions
8:30 AM - 9:45 AM
Regency Ballroom 1
Prenatal Maternal Environment, Immune
Mechanisms, and Neurodevelopment Relevant to
Psychiatric Disorders and Preventive Mechanisms
9:45 AM - 11:00 AM
Regency Ballroom 1
Harnessing Sex-Differences as Biological Clues in
Neurodevelopmental Psychiatry
Panel Sessions
8:30 AM - 11:00 AM
Complimentary and Integrative Treatment for Mood
and Anxiety Disorders
8:30 AM - 11:00 AM
Regency Ballroom 3
Synaptic Addiction: New Insights Into the Cellular
Mechanisms of Drug Action and Substance Use
Disorders
8:30 AM - 11:00 AM
Regency Ballroom 2
Normalizing Cognitive Impairments in
Schizophrenia: New Leads From Novel
Glutamatergic Manipulations
8:30 AM - 11:00 AM
Atlantic Ballroom 1
The Research Domain Criteria (RDoC) Initiative:
New Data Across Psychiatric Conditions and Age
Groups
8:30 AM - 11:00 AM
Atlantic Ballroom 2
Caffeine Interactions with Dopamine in
Adolescence: An Unappreciated Risk for Obesity
and Addiction?
Study Group Session
8:30 AM - 11:00 AM
Great Hall 5-6
The Sunshine Act: Implications for
Neuropsychiatric Researchers and
Neuropsychiatric Research - An ACNP Liaison
Committee-Sponsored Study Group
10:30 AM - 4:30 PM
Poster Viewing
Great Hall 1-4
11:15 AM - 12:30 PM
Regency Ballroom 2
Business Meeting (ACNP members only)
12:30 PM - 2:00 PM
Lunch
Great Hall 1-4
12:30 PM - 2:00 PM
Grand Ballroom
Travel Award Luncheon (by invitation)
1:00 PM - 2:00 PM
Diplomat Ballroom 5
Corporate Liaison Luncheon (by invitation)
2:30 PM - 4:30 PM
Panel Sessions
3:00 PM - 5:30 PM
Sex Hormones, the Medial Prefrontal Cortex and
Their Role on Eating Disorder Behavior in Basic
Science and Human Brain Imaging Studies
3:00 PM - 5:30 PM
Regency Ballroom 3
A Fresh Perspective on Neuregulin in
Schizophrenia
3:00 PM - 5:30 PM
Regency Ballroom 2
Real-Life Proxies of Social Context in Affective
Problems Across the Lifespan: Evidence From
Human and Rodent Studies
3:00 PM - 5:30 PM
Atlantic Ballroom 1
Advances From 3 Hallmark Genetic Consortia
on Endophenotypes in Schizophrenia to Four
Collaborations Operating at the Exciting Frontiers
of Genomic Science
3:00 PM - 5:30 PM
Atlantic Ballroom 2
The Role of Neuroinflammation in Depression: PET
Imaging and Clinical Implications
3:00 PM - 5:30 PM
Atlantic Ballroom 3
Fear Generalization: Neurobiological and
Behavioral Mechanisms Across the Pre-Clinical
and Clinical Spectrum
3:00 PM - 5:30 PM
Regency Ballroom 1
Probing the Perinatal Expression of Risk for
Mental Disorder: Basic Molecular, Neurobiological,
Neuroimaging and Clinical Intervention Studies in
Pregnancy and Fetal Development
Study Group Session
3:00 PM - 5:30 PM
Great Hall 5-6
Neurocircuit-Based Interventions in Addictions:
When and How?
5:30 PM - 7:30 PM
Poster Session III with Reception
Great Hall 1-4
7:30 PM - 8:30 PM
Diplomat Ballroom 4
Women Mentees and Mentors Reception
Thursday, December 10, 2015
7:00 AM - 8:00 AM
Room 212
ACNP, ECNP, CINP, and AsCNP Leadership Meeting
7:00 AM - 9:00 AM
Morning Break
7:30 AM - 3:00 PM
Registration
Thursday, December 10, 2015
Panel Sessions
8:00 AM - 10:30 AM
The Role of Impulsivity vs. Impulse Control on the
Developmental Trajectories of SUD - New Insights
from Neuroimaging Research
8:00 AM - 10:30 AM
Regency Ballroom 3
Ontogeny of Autism: Identification of Very Early
Signs of Autism Spectrum Disorder in Humans
and Mice
8:00 AM - 10:30 AM
Regency Ballroom 2
Using Neural Connectivity Biomarkers in Major
Depressive Disorder (MDD) to Identify Subtypes
and Predict Treatment Response
8:00 AM - 10:30 AM
Atlantic Ballroom 1
Combining Imaging Modalities in Understanding
and Treating Stress-Related Disorders
8:00 AM - 10:30 AM
Atlantic Ballroom 2
Genomes and Cells: New Models for Target
Discovery and Validation
8:00 AM - 10:30 AM
Atlantic Ballroom 3
Studies of Stress Identify Novel Signal Transduction
and Epigenetic Antidepressant Targets
8:00 AM - 10:30 AM
Regency Ballroom 1
Orphan GPCRs and Psychiatric Disorders
Study Group Session
8:00 AM - 10:30 AM
Great Hall 5-6
Addictions Neuroclinical Assessment:
The Search Continues
9:00 AM - 12:00 PM
ACNP Council Meeting
Room 319-320
10:30 AM - 12:00 PM
Brunch
Mini Panel Sessions
12:00 PM - 1:15 PM
Regency Ballroom 1
Revisiting the Mu Opiate Receptor for the
Treatment of Depression
1:15 PM - 2:30 PM
Regency Ballroom 1
DBS and the Identification of Circuits Mediating
Depression
Panel Sessions
12:00 PM - 2:30 PM
The Re-Emergence of Serotonergic Hallucinogens
as Tools for Neuropsychopharmacology
12:00 PM - 2:30 PM
Regency Ballroom 3
Beta Arrestin Signaling: An Avenue to Novel
Psychopharmacology
12:00 PM - 2:30 PM
Regency Ballroom 2
Novel Molecular Targets in Cocaine Addiction
12:00 PM - 2:30 PM
Atlantic Ballroom 1
Visualizing Neurocircuit Dynamics in Rodent
Models of Addiction and Anxiety
12:00 PM - 2:30 PM
Atlantic Ballroom 2
Translational Neural Network Approaches
for Identifying Individualized Targets for
Neurostimulation in Mood Disorders and OCD
12:00 PM - 2:30 PM
Atlantic Ballroom 3
New Twists on Transmembrane Transporter
Function in Psychiatric and Neurodegenerative
Disorders
Study Group Session
12:00 PM - 2:30 PM
Regency Ballroom 1
Methodological Challenges in Human
Pharmacogenetic Studies in Alcohol and Drug
Abuse – What has Early Experience Taught us,
Where to Next?
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Tuesday, December 8th
Morning Mini-Panel Sessions
• Sharing is Caring: An Overview of the Data Sharing Landscape. . . . . 107
• Brain-Wide ‘Glymphatic’ Pathway: Visualization and Function. . . . . 108
Morning Panel Sessions
• Behavioral Implications of Adult Neurogenesis and Its Potential as
Treatment Target. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
• The Role of Epigenetic Mechanisms in the Transition Into Alcohol
Addiction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 110
• From Animals to Humans: The Role of Neuroinflammation in Psychosis
and Psychosis Risk. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
• Genetic Approaches to Delay Discounting: Human and Non-Human
Animal Approaches. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112
• The Road to Recovery: Delineating the Neural Circuits of Compulsive
Drug Use. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Morning Study Group Session
• The Future of Sex Difference Research in
Neuropsychopharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114
• rt-fMRI Neurofeedback: Are We There Yet? . . . . . . . . . . . . . . . . . . . . 115
Women’s Luncheon. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116
Career Development Session. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Afternoon Mini-Panel Sessions
• Social (Cognitive) Functioning in Schizophrenia:
Course, Mechanisms, and Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . 118
• Neuropsychiatric Disorders in Isolated Populations. . . . . . . . . . . . . . . 119
Afternoon Panel Sessions
• Signals From the 4th Dimension: How the Extracellular Matrix
Regulates Synaptic Plasticity and Neuropsychiatric Disease. . . . . . . .
• Neuroimaging, Addiction and Big Data: Opportunities and
Challenges. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
• Schizophrenia as a “Dysplasticity” Disorder. . . . . . . . . . . . . . . . . . . .
• Inflammation-Induced Modulation of Motivation: Impact on
Neurotransmitters and Neurocircuits . . . . . . . . . . . . . . . . . . . . . . . . . .
120
121
122
123
vii
11/10/15 9:58 AM
Tuesday, December 8th (continued)
• Molecular Mechanisms Underlying Psychopathology and
Treatments in OCD. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
• Research Paradigms and Non-Pharmacological Interventions
Aimed to Prevent the Onset and Progression of Bipolar Disorder
in Children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Afternoon Study Group Sessions
• Training Aspects of International Research Collaborations:
Experiences from Multinational Initiatives in Biological
Psychiatry Between the USA, Europe, Asia, and Africa . . . . . . . . . . . 126
Wednesday, December 9th
Morning Mini-Panel Sessions
• Prenatal Maternal Environment, Immune Mechanisms,
and Neurodevelopment Relevant to Psychiatric Disorders
and Preventive Mechanisms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
• Harnessing Sex-Differences as Biological Clues in
Neurodevelopmental Psychiatry. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130
• Complimentary and Integrative Treatment for Mood and Anxiety
Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
• Synaptic Addiction: New Insights Into the Cellular
Mechanisms of Drug Action and Substance Use Disorders. . . . . . . . .
• Normalizing Cognitive Impairments in Schizophrenia:
New Leads From Novel Glutamatergic Manipulations . . . . . . . . . . . .
• The Research Domain Criteria (RDoC) Initiative:
New Data Across Psychiatric Conditions and Age Groups . . . . . . . . .
• Caffeine Interactions with Dopamine in Adolescence:
An Unappreciated Risk for Obesity and Addiction?. . . . . . . . . . . . . . .
• Mining a Genomic Hotspot for Psychosis: Mechanistic
Insights from 22q11.2 Microdeletions . . . . . . . . . . . . . . . . . . . . . . . . .
131
132
133
134
135
136
• The Sunshine Act: Implications for Neuropsychiatric
Researchers and Neuropsychiatric Research An ACNP Liaison Committee-Sponsored Study Group. . . . . . . . . . . . 137
viii
11/10/15 9:58 AM
Wednesday, December 9th (continued)
• Sex Hormones, the Medial Prefrontal Cortex and Their Role
on Eating Disorder Behavior in Basic Science and Human
Brain Imaging Studies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138
• A Fresh Perspective on Neuregulin in Schizophrenia. . . . . . . . . . . . . . 139
• Real-Life Proxies of Social Context in Affective Problems
Across the Lifespan: Evidence From Human and Rodent Studies. . . . 140
• Advances From Three Hallmark Genetic Consortia on Endophenotypes
in Schizophrenia to Four Collaborations Operating at the Exciting
Frontiers of Genomic Science. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
• The Role of Neuroinflammation in Depression:
PET Imaging and Clinical Implications. . . . . . . . . . . . . . . . . . . . . . . . 142
• Fear Generalization: Neurobiological and Behavioral Mechanisms
Across the Pre-Clinical and Clinical Spectrum . . . . . . . . . . . . . . . . . . 143
• Probing the Perinatal Expression of Risk for Mental Disorder:
Basic Molecular, Neurobiological, Neuroimaging and Clinical
Intervention Studies in Pregnancy and Fetal Development. . . . . . . . . 144
• Neurocircuit-Based Interventions in Addictions: When and How?. . . 145
Thursday, December 10th
• The Role of Impulsivity vs. Impulse Control on the Developmental
Trajectories of SUD - New Insights from Neuroimaging Research. . . 147
• Ontogeny of Autism: Identification of Very Early Signs
of Autism Spectrum Disorder in Humans and Mice. . . . . . . . . . . . . . . 148
• Using Neural Connectivity Biomarkers in Major Depressive Disorder
(MDD) to Identify Subtypes and Predict Treatment Response . . . . . . 149
• Combining Imaging Modalities in Understanding and Treating
Stress-Related Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
• Genomes and Cells: New Models for Target Discovery and
Validation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
• Studies of Stress Identify Novel Signal Transduction and
Epigenetic Antidepressant Targets . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152
• Orphan GPCRs and Psychiatric Disorders. . . . . . . . . . . . . . . . . . . . . . 153
ix
11/10/15 9:58 AM
Thursday, December 10th (continued)
• Addictions Neuroclinical Assessment: The Search Continues. . . . . . . 154
Afternoon Mini-Panel Sessions
• Revisiting the Mu Opiate Receptor for the Treatment of
Depression. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
• DBS and the Identification of Circuits Mediating Depression. . . . . . . 156
• The Re-Emergence of Serotonergic Hallucinogens as Tools for
Neuropsychopharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
• Beta Arrestin Signaling: An Avenue to Novel
Psychopharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
• Novel Molecular Targets in Cocaine Addiction. . . . . . . . . . . . . . . . . .
• Visualizing Neurocircuit Dynamics in Rodent Models of
Addiction and Anxiety . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
• Translational Neural Network Approaches for Identifying
Individualized Targets for Neurostimulation in Mood
Disorders and OCD. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
• New Twists on Transmembrane Transporter Function in
Psychiatric and Neurodegenerative Disorders . . . . . . . . . . . . . . . . . . .
157
158
159
160
161
162
• Methodological Challenges in Human Pharmacogenetic
Studies in Alcohol and Drug Abuse – What has Early
Experience Taught us, Where to Next?. . . . . . . . . . . . . . . . . . . . . . . . . 163
Poster Sessions
Poster Session I. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165
Poster Session II. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Poster Session III . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Disclosures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283
Author Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
x
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Acknowledgments
The American College of Neuropsychopharmacology appreciates the support of
our supporting corporations:
Alkermes, Inc.
Astellas Pharma
Boehringer Ingelheim
Eli Lilly USA, LLC
Euthymics/Neurovance
Forest Laboratories, Inc.
Forum Pharmaceuticals
H. Lundbeck A/S, Denmark
Hoffmann-LaRoche, Inc.
Intra-Cellular Therapies, Inc.
Janssen Pharmaceuticals, Inc.
Otsuka America Pharmaceutical, Inc.
Otsuka Pharmaceutical Development and Commercialization, Inc.
Sunovion Pharmaceuticals, Inc.
Takeda Pharmaceuticals
Vanderbilt University School of Medicine Department of Psychiatry and the
American College of Neuropsychopharmacology express appreciation to the
following companies for their support of this educational activity by providing an
unrestricted educational grant:
Alkermes, Inc.
Eli Lilly USA, LLC
Janssen Pharmaceuticals, Inc.
1
11/10/15 9:58 AM
Council
Officers and Council
President Raquel E. Gur
President-Elect Alan Frazer
President-Elect Designate Anissa Abi-Dargham
Secretary David Rubinow
Secretary-Elect Joseph Coyle
Treasurer David J. Kupfer
Council Barry Everitt
Suzanne N. Haber
Peter W. Kalivas
David A. Lewis
Robert C. Malenka
James Meador-Woodruff
Marina Wolf
Council-Elect
Antonello Bonci
Rita Valentino
Program Committee
2015 Program and Scientific Communications Committee
Chair Bita Moghaddam
Co-Chair Carlos A. Zarate
Council Liaison
Alan Frazer
Members:
Caleb Adler
Olusola Ajilore
Susan Andersen
Anne Andrews
Gary Aston-Jones
Carlos Bolanos-Guzman
John Bruno
Cheryl Corcoran
Michael Davidson
Melissa DelBello
Pamela DeRosse
Ariel Deutch
Stephen Deutsch
Darin Dougherty
Stephanie Dulawa
Cindy Ehlers
Mary-Anne Enoch
Rita Goldstein
David Grandy
Robert Greene
Ming-Hu Han
Robert Innis
Katherine Karlsgodt
Amanda Law
Francis Lee
Anil Malhotra
Stephen Marder
Keri Martinowich
Barbara Mason
Daniel Mathalon
Colleen McClung
Mary Phillips
Paul Phillips
Uma Rao
Scott Russo
Thomas Schulze
Jeremy VeenstraVanderWeele
Karoly Mirnics
2
11/10/15 9:58 AM
General Information
Dates and Location
Dates
Location
Sunday, December 6, 2015 - Thursday, December 10, 2015
Diplomat Resort & Spa, Hollywood, Florida
Program Book
All scientific registrants will receive a Program Book as part of their
registration material. The Program Book is also available on the ACNP website,
www.acnp.org.
Itinerary Planner
All scientific registrants will be able to access the itinerary planner for the
54th ACNP Annual Meeting at: https://acnp.societyconference.com/conf/
ACNP Executive Office
ACNP Executive Office
5034A Thoroughbred Lane
Brentwood, Tennessee 37027
USA
Phone:615-324-2360
Fax:615-523-1715
E-mail:acnp@acnp.org
3
11/10/15 9:58 AM
Continuing Medical Education
The 2015 ACNP Annual Meeting has been planned and implemented
in accordance with the accreditation requirements and policies of the
Accreditation Council for Continuing Medical Education through the joint
providership of Vanderbilt University School of Medicine and the ACNP.
Vanderbilt University School of Medicine is accredited by the ACCME to provide
continuing medical education for physicians.
Vanderbilt University School of Medicine designates this live activity for a maximum
of 33.50 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit
commensurate with the extent of their participation in the activity.
There will be a $40.00 charge for scientific registrants to obtain CME credits. CME
instructions will be available at the meeting registration desk and on the ACNP website
(www.acnp.org).
It is the policy of Vanderbilt University School of Medicine to require disclosure of
financial relationships from individuals in a position to control the content of a CME
activity; to identify and resolve conflicts of interest related to those relationships; and
to make disclosure information available to the audience prior to the CME activity.
Presenters are required to disclose discussions of unlabeled/unapproved uses of drugs or
devices during their presentations.
Program Overview/Statement of Need
The Annual Meeting of the American College of Neuropsychopharmacology is designed
to meet the educational needs of ACNP members and invited non-member colleagues. Current data suggests that in any given year more than 20% of the U.S. adult population
suffers from a diagnosable mental disorder. Four of the ten leading causes of disability in
the U.S. are psychiatric disorders, including schizophrenia, depression, bipolar disorder,
and obsessive-compulsive disorder. ACNP members have been among the leaders in
identifying underlying mechanisms for these disorders and developing new treatment
strategies. The desired results for the meeting are that ACNP members and their
invited guests learn of the latest developments in preclinical and clinical research being
performed by their colleagues and world experts in order to 1) enhance understanding of
the neurobiological bases of current best practice approaches, 2) enhance understanding
of neurobiological and clinical science underpinnings in development of novel
therapeutic strategies, particularly for treatment-resistant forms of illness, and 3) lead to
improvements in study designs for proposed clinical and basic studies.
4
11/10/15 9:58 AM
Continuing Medical Education (continued)
Target Audience
The target audience includes members of the American College of Neuropsychopharmacology and invited experts. The audience includes physicians, psychologists, and basic
neuroscientists from across the United States as well as Europe and Asia. The physicians
include a number of specialties, with psychiatrists representing the majority of attendees,
and neurologists next most common. Psychologists include clinical psychologists and
neuropsychologists.
Learning Objectives:
After participating in this CME activity, participants should be able to:
• Describe and discuss how the results of recent or ongoing basic science and/or
clinical studies of psychiatric disorders in your area of interest or a related area
impact your current or potential future research projects.
• Describe and discuss how you will change or modify a current approach or
strategy in your current or potential future research projects based on what you
learned from the results of recent or ongoing basic science and/or clinical studies
of psychiatric disorders in your area of interest or a related area.
• Describe and discuss how recent progress in identifying genetic variations that
are risk factors for the development of psychiatric disorders affect your current
or potential future research projects.
Americans with Disabilities Act
It is the policy of Vanderbilt University School of Medicine not to discriminate against
any person on the basis of disabilities. If you feel you need services or auxiliary aids
mentioned in this act in order to fully participate in this continuing education activity,
please call the Executive Office at 615-324-2360 or send an email to acnp@acnp.org
Meeting Evaluation
All meeting attendees are urged to complete an evaluation of the meeting.
Attendees who are requesting CME credit for the meeting are required to
complete the evaluation. This form is available online only. You may complete
the evaluation in the ACNP Computer Center located in Diplomat Ballroom 1 & 2
foyer or on-line at www.acnp.org (click the Annual Meeting tab). All evaluations
must be completed by January 12, 2016.
5
11/10/15 9:58 AM
Code of Behavior
ACNP does not accept inappropriate or suggestive acts or comments that demean
another person by reason of his or her gender, gender identity or expression,
race, religion, ethnicity, age or disability. Any reports of such behavior will
be investigated and acted upon as indicated by the specific findings of the
investigation.
Future ACNP Annual Meetings
DatesHotel
Location
December 4-8, 2016 December 3-7, 2017
December 9-13, 2018
December 8-12, 2019 Hollywood, Florida
Palm Springs, California
Hollywood, Florida
Hollywood, Florida
Diplomat Resort & Spa
JW Marriott Desert Springs Resort Diplomat Resort & Spa
Diplomat Resort & Spa
In Memoriam
Albert Sjoerdsma
February 27, 2014
John David Leander
November 14, 2014
B. Kenneth Koe
October 7, 2015
Joel Elkes
October 30, 2015
Lori Altshuler
November 5, 2015
6
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8:30 AM - 11:30 AM
Neuropsychopharmacology Reviews Plenary
Regency 1-2
PL
“Stress and Development: Molecular, Neurobiological, and Genetic
Approaches to Understanding Pathology”
Co-Chairs: Kerry Ressler and Jordan Smoller
8:30 AM
Stress Effects on Neuronal Structure: Hippocampus, Amygdala,
and Prefrontal Cortex
Bruce McEwen
8:55 AM
Local Circuits and Neural Pathways Linking Adult Hippocampal
Neurogenesis With Fear Generalization
Amar Sahay
9:20 AM
Sex-Specific Transmission of Maternal Stress: Placenta and
Neurodevelopment
Tracy Bale
9:45 AM
Gene-Environment-Epigenetic Regulation of FKBP5:
Implications for Translational Research
Elisabeth Binder
10:10 AM
Neuro-Development of Emotion Regulation and the Role of
Caregiving
Nim Tottenham
10:35 AM
Discussion
Kerry Ressler and Jordan Smoller
7
11/10/15 9:58 AM
PL
8:30 AM - 11:30 AM
Regency 1-2
Bruce McEwen
The Rockefeller University
The hippocampus provided the gateway into much of what we have learned
about stress and brain structural and functional plasticity, and this initial focus
has expanded to other interconnected brain regions, such as the amygdala and
prefrontal cortex. Starting with the discovery of adrenal steroid, and later,
estrogen receptors in the hippocampal formation, and subsequent discovery of
dendritic and spine synapse remodeling and neurogenesis in the dentate gyrus,
mechanistic studies have revealed both genomic and rapid non-genomic actions
of circulating steroid hormones in the brain. Many of these actions occur
epigenetically and result in ever-changing patterns of gene expression, in which
there are important sex differences that need further exploration. Moreover,
glucocorticoid and estrogen actions occur synergistically with an increasing
number of cellular mediators that help determine the qualitative nature of the
response. The hippocampus has also been a gateway to understanding lasting
epigenetic effects of early-life experiences. These findings in animal models have
resulted in translation to the human brain and have helped change thinking about
the nature of brain malfunction in psychiatric disorders and during aging, as well
as the mechanisms of the effects of early-life adversity on the brain and the body.
Bruce S. McEwen obtained his Ph.D. in Cell Biology in 1964 from The Rockefeller
University. He is a member of the US National Academy of Sciences, the Institute
of Medicine, and the American Academy of Arts and Sciences. He served as
President of the Society for Neuroscience in 1997-98. As a neuroscientist and
neuroendocrinologist, McEwen studies environmentally-regulated, variable gene
expression in brain, mediated by circulating steroid hormones and endogenous
neurotransmitters in relation to brain sexual differentiation and the actions of
sex and stress hormones on the adult brain, in particular related to structural and
functional plasticity via epigenetic mechanisms. His laboratory discovered adrenal
steroid receptors in the hippocampus in 1968. His laboratory combines molecular,
8
11/10/15 9:58 AM
8:30 AM - 11:30 AM
Regency 1-2
PL
Bruce McEwen (continued)
anatomical, pharmacological, physiological and behavioral methodologies and
relates their findings to human clinical information. His current research focuses
on stress effects on amygdala and prefrontal cortex, as well as hippocampus, and
his laboratory also investigates sex hormone effects and sex differences in these
brain regions involved in cognitive function and mood regulation. He served
on the MacArthur Foundation Research Network on Socioeconomic Status and
Health, in which he has helped to reformulate concepts and measurements related
to stress and stress hormones in the context of human societies, which led to the
concept of “allostatic load and overload” that describes the wear and tear on the
body and brain from chronic stress and related life style behaviors that lead to
dysregulation of physiological stress pathways that are normally protective. He
is also a member of the National Council on the Developing Child which focuses
on biological embedding of early life experiences and promoting healthy brain
development. He is the co-author of a book with science writer, Elizabeth Lasley,
for a lay audience called “The End of Stress as We Know It”, published in 2002,
and “The Hostage Brain” with science writer, the late Harold M. Schmeck, Jr.,
published in 1994, both of which are now available as eBooks.
9
11/10/15 9:58 AM
PL
8:30 AM - 11:30 AM
Regency 1-2
Local Circuits and Neural Pathways Linking Adult
Hippocampal Neurogenesis with Fear Generalization
Amar Sahay
Massachusetts General Hospital and Harvard Medical School
The generation of adaptive fear responses to ambiguous threats in the environment
is critically dependent on how contextual information is encoded and relayed
across multiple circuits. Inefficient encoding of ambiguous threats results
in inappropriate retrieval of aversive memories and activation of fear circuits
to produce heightened avoidance behavior, overgeneralization of fear, hyper
vigilance and arousal, symptoms that characterize anxiety disorders such as
post-traumatic stress disorder. Recent studies by us and others have found that
adult-born neurons in the hippocampus play a critical role in discrimination of
ambiguous threats and modulating generalization of fear. One neural mechanism
by which this may be accomplished is pattern separation, a process by which
interference between similar memories is minimized. However, despite these
advances, fundamental questions remain unaddressed. First, what are the local
circuit mechanisms by which adult-born hippocampal neurons contribute to
pattern separation and memory precision? Second, what are the neural pathways
linking encoding operations performed by the dentate gyrus-CA3 circuit with
circuits subserving stress and fear responses? I will discuss ongoing studies that
have begun to illuminate these questions.
Dr. Amar Sahay is Assistant Professor of Psychiatry at Harvard Medical School
and Director of the laboratory of Adult Hippocampal Neurogenesis, Cognition
and Mood Regulation in the Center for Regenerative Medicine at Massachusetts
General Hospital. He is principal faculty of the Harvard Stem Cell Institute of
Harvard University and an Associate member of the BROAD Institute of Harvard
and MIT. Dr. Sahay earned his doctorate from the Johns Hopkins University
School of Medicine and carried out postdoctoral research at Columbia University.
The mission of Dr. Sahay’s laboratory is to generate fundamental insights into the
roles of adult hippocampal neurogenesis in encoding, memory processing and
modulation of mood. By integrating cellular-, circuit-, systems- and behavioral
10
11/10/15 9:58 AM
8:30 AM - 11:30 AM
Regency 1-2
PL
Local Circuits and Neural Pathways Linking Adult
Hippocampal Neurogenesis with Fear Generalization
Amar Sahay (continued)
interrogation of adult hippocampal neurogenesis, his research program aspires to
optimize hippocampal functions in PTSD and during aging (http://www.sahaylab.
com). Dr. Sahay is the recipient of numerous awards including NIH K99 Pathway
to Independence award, NIMH-BRAINS award, NARSAD Young Investigator
awards and career development awards from the Society for Neuroscience and
the American College of Neuropsychopharmacology. His research program is
supported by Whitehall Foundation, Harvard Stem Cell Institute, Inscopix Decode
Award, Ellison Medical Foundation and the National Institute of Mental Health.
11
11/10/15 9:58 AM
PL
8:30 AM - 11:30 AM
Regency 1-2
Neurodevelopment
Tracy Bale
University of Pennsylvania
Adversity experienced during gestation is a risk factor in neurodevelopmental
disorder susceptibility. Specifically, maternal stress during pregnancy predisposes
offspring to sex-biased disorders including schizophrenia, attention deficit/
hyperactivity disorder, and autism spectrum disorders. Animal models have
demonstrated disease-relevant endophenotypes in prenatally stressed offspring.
We have previously identified a sensitive period of early pregnancy where
maternal stress produces male-specific programming effects on offspring stress
pathway development and neuroendocrine regulation. Mechanistically, the
placenta plays a critical role in transmitting the potentially deleterious and sexspecific effects of maternal stress to the developing brain. In our mouse model of
early prenatal stress, we have found robust and male-specific changes in placental
gene expression patterns and biochemical measures across gestation. We have
subsequently utilized mouse genetics to demonstrate the importance of placental
function in neurodevelopmental programming, including trophoblastic-specific
targeting of genes identified in whole genome screening in our mouse model
that recapitulate disease-relevant endophenotypes. Such studies support a critical
importance of the placenta in transmission of maternal experiences and exposures
during pregnancy on the fetal brain.
Tracy L. Bale is Professor of Neuroscience in the Department of Psychiatry in
the Perelman School of Medicine and the Biomedical Sciences Department in the
School of Veterinary Medicine. She completed her Ph.D. in pharmacology and
neurobiology at the University of Washington, and her postdoctoral fellowship
at the Salk Institute. Her research focuses on understanding the role of stress
dysregulation in neurodevelopmental and neuropsychiatric diseases, and the sex
differences that underlie disease vulnerability using mice as the model organism.
She is the Director of the Neuroscience Center and the Co-director of the Penn
Center for the Study of Sex and Gender in Behavioral Health, funded by a NIMH
12
11/10/15 9:58 AM
8:30 AM - 11:30 AM
Regency 1-2
PL
Neurodevelopment
Tracy Bale (continued)
and ORWH SCOR P50 grant. She serves on many internal and external advisory
committees, panels, and boards and is currently a Reviewing Editor at the Journal
of Neuroscience and serves as Chair of the NNRS study section. She has been
the recipient of several awards for her research in this area including the career
development award for early career achievement and promise by the Society
for Neuroscience, the Richard E. Weitzman Memorial award as exceptionally
promising young investigator award by the Endocrine Society, and Medtronic
Award from the Society for Women’s Health Research for outstanding research
that has led to the improvement of women’s health.
13
11/10/15 9:58 AM
PL
8:30 AM - 11:30 AM
Regency 1-2
Elisabeth Binder
Emory University School of Medicine
Stress responses and related outcomes vary markedly across individuals.
Elucidating the molecular underpinnings of this variability is of great relevance
for developing individualized prevention strategies and treatments for stressrelated disorders. An important modulator of stress responses is the FK506 binding
protein 51 (FKBP5/FKBP51). FKBP5 acts as a co-chaperone that modulates
glucocorticoid receptor activity in response to stressors but also a multitude of
other cellular processes in both the brain and periphery. Notably, the FKBP5 gene
is regulated via complex interactions among environmental stressors, FKBP5
genetic variants, and epigenetic modifications of glucocorticoid-responsive
genomic sites. These interactions can result in FKBP5 disinhibition that has
been shown to contribute to a number of aberrant phenotypes in both rodents
and humans. Consequently, FKBP5 blockade may hold promise as treatment
intervention for stress-related disorders, and recently developed selective FKBP5
blockers show encouraging results in vitro and in rodent models. While risk
for stress-related disorders is conferred by multiple environmental and genetic
factors, the findings related to FKBP5 illustrate how a deeper understanding of
the molecular and systemic mechanisms underlying specific gene-environment
interactions may provide insights into the pathogenesis of stress-related disorders.
Elisabeth Binder has studied Medicine at the University of Vienna, Austria and
Neuroscience at Emory University in Atlanta, GA, USA. Following a postdoctoral
training at the Max-Planck Institute of Psychiatry in Munich, Germany, she
returned to Emory University as an Assistant Professor in the Departments of
Psychiatry and Behavioral Sciences and Human Genetics. In 2007, she was
appointed as research group leader at the Max-Planck Institute of Psychiatry
within the Minerva Program of the Max-Planck Society.
14
11/10/15 9:58 AM
8:30 AM - 11:30 AM
Regency 1-2
PL
Elisabeth Binder (continued)
Since August 2013, Elisabeth Binder is the director of the Department of
Translational Research in Psychiatry at the Max-Planck Institute of Psychiatry.
She also holds an appointment as an Associate Professor in the Dept. of Psychiatry
and Behavioral Sciences at Emory University School of Medicine. Her main
research interests are the identification of molecular moderators of the response
to environmental factors, with a focus on early trauma and gene x environment
interactions. She studies how such factors influence trajectories to psychiatric
disease or well-being to ultimately use this information for novel prevention and
treatment strategies.
15
11/10/15 9:58 AM
PL
8:30 AM - 11:30 AM
Regency 1-2
Caregiving
Nim Tottenham
Columbia University
Early experiences critically shape the structure and function of the brain.
Perturbations in typical/species-expected early experiences are known to have
profound neural effects, especially in regions important for emotion regulation.
Parental care is one species-expected stimulus that plays a fundamental role in
the development of emotion neurocircuitry. Phasic variations in parental presence
during sensitive periods of development affect the state of emotional networks on
a moment-to-moment basis. Also, it appears that increasing independence from
caregivers cues the termination of the sensitive period for environmental input
into emotion network development. This talk will discuss how early parental
care, the central nervous system, and behaviour come together to form a ‘neuroenvironmental loop’, contributing to the formation of stable emotion regulation
circuits. To achieve this end, I focus on the interaction of parental care and the
developing amygdala-medial prefrontal cortex (mPFC) network – which lies at
the core of human emotional functioning. I will discuss how individual or group
variations in parental-independence, across chronic and brief timescales, might
contribute to neural and emotional phenotypes that have implications for longterm mental health.
Nim Tottenham, Ph.D. is an associate professor of Psychology at Columbia
University. Her research uses magnetic resonance imaging and behavioral methods
to examine the development of the human amygdala and its neural connections
and associated emotional development, including emotional reactivity and
management with the aim of identifying sensitive periods for human amygdalacortical development. She examines limbic-cortical development in both typical
groups of children and adolescents and those who have experienced early life
adversity (parental deprivation). She is a recipient of the American Psychological
Association’s Distinguished Scientific Award for Early Career Contribution to
Psychology, the National Institute of Mental Health Biobehavioral Research
16
11/10/15 9:58 AM
8:30 AM - 11:30 AM
Regency 1-2
PL
Caregiving
Nim Tottenham (continued)
Awards for Innovative New Scientists (BRAINS) Award, and the Developmental
Science Early Career Researcher Prize. She received her bachelor’s degree in
Psychology from Barnard College of Columbia University and her doctoral
degree from the University of Minnesota. She received postdoctoral training
from the Sackler Institute for Developmental Psychobiology at Weill Cornell
Medical College. More information on her research and laboratory can be found
at: http://tottenhamlab.psych.columbia.edu/.
17
11/10/15 9:58 AM
PL
1:00 PM - 2:30 PM
Institute Director’s Session
Regency 1-2
Q & A Forum with NIH Institutes Directors
Chair: Raquel Gur
Panelists:
Neil Buckholtz
NIA
George Koob
NIAAA
Bruce Cuthbert
NIMH
Richard Nakamura
NIH
Nora Volkow
NIDA
18
11/10/15 9:58 AM
2:30 PM - 5:30 PM
Hot Topics
Regency 1-2
PL
Hot Topics
Co-Chairs: Bita Moghaddam and Carlos Zarate
2:30 PM
Deconstructing Ventral Hippocampal Control of Anxiety-Related
Behavior and Learned Fear
Jessica Jimenez
2:45 PM
Deficits in Working Memory Performance in Schizophrenia
are Associated With the Absence of an Inverted-U Relationship
Between Dorsolateral Prefrontal Cortex Activation and Working
Memory Load
Jared Van Snellenberg
3:00 PM
A Single Dose of SSRI Alters the Neural Circuit Underlying the
Management of Attentional Resources to Emotional Distraction
Within 3 Hours
Julia Sacher
3:15 PM
Arithmetic and Local Circuitry Underlying Dopamine Prediction
Errors
Neir Eshel
3:30 PM
Metabotropic Glutamate Receptor 5 Binding in Individuals With
Schizophrenia
Gregor Hasler
3:45 PM
A Novel Genetic Method of Measuring the Receptor-Specific
Component of PET Radioligand Binding in Human Brain
Without Pharmacological Blockade
Robert Innis
19
11/10/15 9:58 AM
PL
2:30 PM - 5:30 PM
Hot Topics
Regency 1-2
Hot Topics
Co-Chairs: Bita Moghaddam and Carlos Zarate
4:00 PM
Affective Neurodynamics Predict Depression Treatment
Response
Aaron Heller
4:15 PM
Impact of Chronic Ethanol Self-Administration on Kappa Opioid
Receptor Regulation of Dopamine Signaling in Nonhuman
Primates
Cody Siciliano
4:30 PM
Dopamine-Dependent Working-Memory Performance is
Mediated by Dynamic Connectivity Between Brain Networks
Guillermo Horga
4:45 PM
Reduced Amplitude Low-Frequency BOLD Signal Oscillations
in Early Illness Schizophrenia Patients and Individuals at Clinical
High Risk for Psychosis
Susanna Fryer
5:00 PM
Selective Estrogen Modulation Increases Dorsolateral Prefrontal
Cortex Activity During Emotional Inhibition in Schizophrenia
Thomas Weickert
5:15 PM
GPR139, an Orphan Receptor Highly Enriched in the Habenula
and Septum, is Activated by the Essential Amino Acids
L-Tryptophan and L-Phenylalanine
Pascal Bonaventure
20
11/10/15 9:58 AM
2:30 PM - 5:30 PM
Hot Topics
Regency 1-2
PL
Deconstructing Ventral Hippocampal Control of AnxietyRelated Behavior and Learned Fear
Tuesday, Poster #16
Jessica Jimenez*, Alexander Goldberg, Gokhan Ordek, Stephanie Pena, Katy
Su, Rene Hen, Mazen Kheirbek
Columbia University
Background: Understanding the distributed neural circuits that mediate normal,
adaptive anxiety-related behavior may provide insight into how they may be
disrupted in anxiety disorders. The ventral hippocampus (vHPC) has become
appreciated for its role in anxiety-related behaviors, serving as a circuit hub
that connects cognitive association regions with limbic structures that directly
regulate mood. Although some studies have observed vHPC activity changes
during anxiety-related behaviors, it is still not understood if this activity is specific
to innately aversive tasks, if vHPC can directly modulate anxiety behavior,
and through which downstream limbic structures these effects on behavior are
mediated.
Methods: We have used cell-type specific calcium imaging in vivo in freely
behaving mice using miniaturized microscopes to visualize vHPC activity during
anxiety-related behaviors. We expressed GCaMP6f in vHPC, and a gradient
index lens was implanted above vCA1. We imaged the activity patterns of
the same population of vCA1 neurons across multiple behavioral dimensions,
including innately anxiogenic tasks (Open Field Test (OFT), Elevated Plus Maze
(EPM), and Elevated Zero Maze (EZM)), innately rewarding tasks (novel object
exploration and sucrose pellet consumption), and learned fear tasks (contextual
fear conditioning (CFC)). For optogenetic manipulations, we virally expressed
Arch or ChR2 opsins in vHPC and implanted a fiber optic either directly in
vHPC or at vHPC terminal fields in the Basomedial Amygdala (BMA) or Lateral
Hypothalamus (LHA).
Results: In our imaging experiments, we found that vHPC neurons increase their
activity in innately anxiogenic environments, including the center of the Open
Field test and the open arms of the Elevated Plus Maze (EPM) and Zero Maze,
21
11/10/15 9:58 AM
PL
2:30 PM - 5:30 PM
Hot Topics
Regency 1-2
Tuesday, Poster #16 (continued)
Jessica Jimenez*
but not to exploration of a novel object. Alternatively, in CFC, re-exposure to a
previously conditioned environment decreases activity within vHPC, suggesting
a differential processing of learned versus innately fearful environments. To
understand how these activity changes are generated within the local vHPC circuit,
we imaged calcium activity in local inhibitory interneurons (VGAT+ neurons)
and found a reduction in inhibitory interneuron activity in innately anxiogenic
environments, such as the open arms of the EPM. This points to a local circuit
mechanism by which the vHPC is engaged during exploration of anxiogenic
environments. To understand how the vHPC may modulate anxiety-related
behavior, we employed optogenetic techniques within vHPC and at downstream
terminal fields in two subcortical nuclei implicated in anxiety, fear, and behavioral
responses to stress, the BMA and LHA. Our results indicate that direct vHPC
silencing disrupts the formation of a contextual fear memory. Further, modulation
of vHPC-LHA terminals impacts innate anxiety and aversion, but not contextual
fear conditioning, while vHPC-BMA terminal modulation impacts contextual
fear memory but not innate anxiety behavior. Ongoing studies are aimed at
understanding the interplay between behavioral state and activity within vHPC,
utilizing pharmacological and behavioral manipulations to modulate anxiety
levels of mice during exploration of the EZM while recording local population
dynamics.
Conclusions: Our findings demonstrate a unique population-level activity
signature for anxiogenic environments within vHPC. Further, the varying activity
changes between innate and learned fear behaviors suggest diverse circuit
mechanisms for processing exploration of an innately anxiogenic environment
and previously conditioned fearful environments. Our results also reveal a
potential circuit mechanism for increased population activity during innate
anxiety behaviors, possibly through disinhibition of the local vCA1 circuit. The
specificity of vHPC-LHA and vHPC-BMA terminal modulation effects on innate
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Tuesday, Poster #16 (continued)
Jessica Jimenez*
and learned fear behavior suggests a projection specific segregation in vHPC
function, possibly mediated through projection-specific cell populations within
the vHPC. This study provides a functional map of the cell-types and long-range
circuits that underlie the vHPC contribution to innate and learned anxiety-related
behavior.
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Memory Load
Wednesday, Poster #180
Jared Van Snellenberg*, Ragy Girgis, Guillermo Horga, Elsmarieke van de
Giessen, Mark Slifstein, Najate Ojeil, Holly Moore, Edward Smith, Daphna
Shohamy, Jeffrey Lieberman, Anissa Abi-Dargham
Columbia University Medical Center
Background: Patients with schizophrenia exhibit strong deficits on
working memory (WM) tasks, but after over two decades of research the
neurophysiological underpinnings of these deficits remain unknown. In spite
of early findings supporting the concept of ‘hypofrontality’, alterations in the
activation of dorsolateral prefrontal cortex (DLPFC), or other prefrontal regions,
have not been reliably observed during WM task performance. However, recent
work in healthy individuals has demonstrated an inverted-U relationship between
DLPFC activation and WM load during a task with eight WM loads, the selfordered WM task (SOT), suggesting that simple comparisons of the magnitude of
activation between patients and healthy individuals will fail to capture a critical
feature of how the brain instantiates WM. The present study employed the SOT
in unmedicated and medicated patients with schizophrenia in order to examine
whether an alteration in this pattern of activation is related to WM deficits in
these patients.
Methods: Participants included 21 unmedicated patients with schizophrenia, 30
medicated patients with schizophrenia, and 45 healthy control participants. All
three groups were matched on age, gender, and parental socio-economic status.
Participants performed the SOT during functional Magnetic Resonance Imaging
on a Philips 1.5 Tesla Intera scanner at the Columbia MRI Center at Columbia
University Medical Center (TR = 2 s, whole-brain coverage with 3 mm isotropic
voxels). In each trial of the SOT participants are presented with eight line
drawings of 3D objects in an array. On each step of the trial the object positions are
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Memory Load
Wednesday, Poster #180 (continued)
Jared Van Snellenberg*
pseudo-randomly rearranged, and participants must select any object that they have
not previously selected, thereby producing a gradual increase in WM load over
the eight steps of each trial. Data were analyzed in a series of robust regression (or
robust t-test) models using alphasim to correct for multiple comparisons (P < 0.05
in all cases); first restricted to a bilateral DLPFC region-of-interest (ROI), then in
whole-brain analyses. Two outcome measures were evaluated in these models: 1)
overall activation in response to the SOT (average activation across all eight WM
loads), in keeping with standard analyses in the literature, and 2) the fit at each
voxel in each subject (i.e. a first-level analysis) to an inverted-U shape identified
in an independent sample of healthy individuals (Study 1 from Van Snellenberg
et al., 2015). Performance on the SOT was analyzed using a maximum likelihood
estimate of WM capacity described elsewhere (Van Snellenberg et al., 2014).
Results: Both patient groups showed a significant reduction in WM capacity
relative to controls (all P < 0.0005). Within the DLPFC ROI, unmedicated patients
showed greater activation of right DLPFC relative to controls, but this was not
related to WM capacity. Medicated patients showed a poorer inverted-U fit in
left DLPFC compared to controls, a finding that was observed in an overlapping
but slightly posterior region of left DLPFC in unmedicated patients in the wholebrain analysis (it did not appear in the ROI analysis because many of the cluster’s
voxels were posterior to the ROI). A follow-up analysis combing both patient
groups showed a significant reduction in the inverted-U fit in this region in patients
as compared to healthy controls. Morever, both healthy controls and patients with
schizophrenia exhibited a positive relationship between inverted-U fit in left
DLPFC and WM capacity. Thus, at least some of the deficit in WM capacity in
patients with schizophrenia can be explained by the lack of an inverted-U response
to WM load in this region. Moreover, whole-brain analyses demonstrated that
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Memory Load
Jared Van Snellenberg*
both patient groups showed excess activation of two default-mode network
(DMN) regions, the medial prefrontal cortex (mPFC) and posterior cingulate.
Moreover, all three groups exhibited a negative relationship between activation
of mPFC and WM capacity. Given that this region was suppressed by the task in
all three groups, inadequate suppression of mPFC during WM performance may
also account for some of the deficit in WM performance in patients.
Conclusions: These findings demonstrate two mechanisms that are associated
with WM deficits in patients with schizophrenia: 1) the absence of an inverted-U
relationship between WM load and activation of the left DLPFC, and 2) a failure
to fully suppress activation in the medial PFC during WM performance. Notably,
overall levels of activation in left DLPFC were normal in patients, and while
patients exhibited abnormally elevated activation in right DLPFC, this increase
was not observed to have any impact on WM capacity across individuals. These
findings point to two little-studied pathophysiological mechanisms that may play
a significant role in WM impairments in patients with schizophrenia, and which
do not appear to be impacted by treatment with antipsychotic medications.
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Within 3 Hours
Claudia Barth, Hadas Okon-Singer, Lina Schaare, Lydia Hellrung, Jöran
Lepsien, Inga Burmann, Arno Villringer, Julia Sacher*
Max Planck Institute
Background: Accumulating evidence supports Selective Serotonin Reuptake
Inhibitor (SSRI) drug-action to reduce the attentional bias to negative information,
which has been proposed to underlie depressive symptomatology (Browning,
Holmes, & Harmer, 2010). This change in emotional processing is mediated by
a prefrontal-limbic neural system that SSRIs modulate on a time-scale that is
much shorter than the 10-14 days typically viewed as required for an adequate
antidepressant response (Harmer & Cowen, 2013). However, existing work in
this field is limited by the paucity of paradigms that can reflect on the ability to
manage attention resources in the face of emotional distraction. An emotional
modification of a perceptual load task (emo-PLT) has recently been applied
to investigate neural changes in emotional processing induced by a dietary
supplement (Terburg et al., 2013). This paradigm allows for variation of cognitive
difficulty in the midst of emotional distraction. Although the management of
processing emotional information during varying cognitive challenges is a skill
often substantially impaired in depression, little is known about the response in
the underlying neural network to the most commonly prescribed antidepressants.
To address this, we study the acute neuropharmacological impact of a single dose
of escitalopram on the neural circuit underlying the management of attentional
resources to emotional distraction.
Methods: To investigate this, 21 healthy subjects performed an emotional
modification of a perceptual load task (Okon-Singer et al., 2014) during fMRI
scanning following a single oral dose of escitalopram (20 mg) or placebo in a
randomized, cross-over design. fMRI data was acquired on a 3-Tesla MR scanner
at tmax for escitalopram and analyzed in SPM8 using standardized preprocessing.
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Within 3 Hours
Julia Sacher*
We applied a flexible factorial design with emotion (negative/neutral) and load
(low/high) as within-subjects factors for the SSRI and the placebo conditions.
We conducted a whole-brain voxel-wise general linear model (GLM) analysis on
the first level and tested the resulting contrast maps for effects of load, emotion
and their interactions (whole-brain family wise error (FWE) corrected p<0.05,
and extend-threshold 10 voxels) to validate the task. To identify the functional
localization of the task-specific cortico-limbic regions implicated in navigating
attention to varying cognitive load during negative emotional distraction, we
performed a paired t-test comparing load (whole-brain FWE corrected p<0.05,
and extend-threshold 10 voxels) only during negative distraction for the respective
single-subject contrasts for the placebo condition. We then performed a secondary
region-of-interest (ROI) analysis in these regions to assess the extent of acute
SSRI-specific neural signal change in the emotion-cognition circuit.
Results: A 2 x 2 x 2 repeated-measures ANOVA with drug, load, and emotion as
within-subject factors revealed main effects of load (F (1,20)=304, p<0.00001)
and emotion (F (1,20)=8,197, p<0.01) for reaction times, and a main effect for
load (F(1,20) =,5,567 p = 0.029) for accuracy. In the placebo condition, these
behavioral effects were paralleled by positive main effects of load (high – low)
in frontal, visual and cerebellar regions (whole brain, FWE-corrected p<0.05).
The contrast of negative minus neutral pictures showed that during distraction by
negative emotion, there was significant BOLD activation in brain regions known to
be involved in the management and processing of emotional information, namely
the insula, temporal cortex, amygdala/hippocampus and orbitofrontal cortex
(OFC) (whole brain, FWE-corrected p<0.05). A single oral dose of escitalopram,
however, substantially attenuated the BOLD responses in these brain regions:
ROI analyses revealed a 146±24 (mean±SD) percent signal change in amygdala,
insula and OFC (p<0.0000001, Bonferroni corrected).
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Within 3 Hours
Julia Sacher*
Conclusions: We demonstrate feasibility to apply a paradigm that detects the
management of attentional resources for a cognitively challenging task in the
midst of emotional distraction in a single-SSRI-dose psychopharmacological
fMRI-design. Our data are consistent with the emerging theory that changes
in the neural circuit underlying emotion-processing following SSRI-intake are
detectable on an acute time-scale as we find changes as early as 3 hours postadministration. Furthermore, we provide strong evidence that a single dose of
escitalopram can significantly reduce the BOLD response in the neural circuit
underlying the behavioral interference of irrelevant emotional distractors
contrasting different levels of cognitive load. These results emphasize that the
management of attentional resources to negative stimuli during varying stages
of cognitive challenge could represent a key mechanism of action during SSRI
treatment. Our findings have important implications for the early evaluation of
antidepressant efficacy in clinical populations and individuals at risk.
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Arithmetic and Local Circuitry Underlying Dopamine
Prediction Errors
Neir Eshel*, Michael Bukwich, Vinod Rao, Vivian Hemmelder, Ju Tian,
Naoshige Uchida
Harvard Medical School
Background: Dopamine neurons signal prediction error, or the difference
between actual and predicted reward. Prediction errors are thought to be crucial
for both adaptive learning and the development of addiction. However, despite
two decades of investigation, little is known about how prediction errors are
calculated in the brain.
Methods: To determine how dopamine neurons calculate prediction error,
we combined optogenetic manipulations with extracellular recordings in the
ventral tegmental area (VTA) while mice engaged in classical conditioning.
Our techniques allowed us to tag recorded neurons as either dopaminergic or
GABAergic, and selectively stimulate or inhibit these neurons while recording
from other neurons in the circuit. We performed 4 experiments, with a total of 33
mice and 632 VTA neurons.
Results: We demonstrate that dopamine neurons perform subtraction, a
computation that is ideal for reinforcement learning but rarely observed in the
brain. Furthermore, selectively exciting and inhibiting neighboring GABA neurons
in the VTA reveals that these neurons are a source of subtraction: they inhibit
dopamine neurons when reward is expected, casually contributing to prediction
error calculations. In particular, we found that stimulating VTA GABA neurons
subtracts from dopamine reward responses (P < 0.001, t-test), as if reward is more
expected, and that inhibiting VTA GABA neurons increases dopamine reward
responses (P < 0.001, t-test), as if reward is less expected. Finally, bilaterally
stimulating VTA GABA neurons dramatically reduces anticipatory licking to
conditioned odours (P < 0.001, mixed effects linear model), consistent with an
important role for these neurons in reinforcement learning. VTA GABA neurons,
therefore, help put the “prediction” in “prediction error.”
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Arithmetic and Local Circuitry Underlying Dopamine
Prediction Errors
Neir Eshel*
Conclusions: Together, our results uncover the arithmetic and local circuitry
underlying dopamine prediction errors. This provides a framework for
understanding how alterations in the circuitry--in particular, inhibition of VTA
GABA neurons--can stimulate a vicious cycle leading to substance addiction.
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Metabotropic Glutamate Receptor 5 Binding in Individuals
With Schizophrenia
Wednesday, Poster # 156
Funda Akkus, Valerie Treyer, Simon Ametamey, Cyrill Burger, Anass Johayem,
Alfred Buck, Gregor Hasler*
University of Bern
Background: The implication of N-methyl-D-aspartate (NMDA) receptors
in schizophrenia has received increasing interest over the last years. NMDA
receptor function is modified by metabotropic glutamate receptors subtype 5
(mGluR5) suggesting that mGluR5 can also be involved in the pathogenesis
of schizophrenia. This notion is corroborated by genetic studies showing that
allele frequency distribution of an intragenic microsatellite of the mGluR5 gene,
GRM5, is associated with schizophrenia. Here, we report the results of a study
investigating mGluR5 in schizophrenia in vivo via positron emission tomography
(PET) with the mGluR5-specific radiotracer 3-(6-methyl-pyridin-2-ylethynyl)cyclohex-2-enone-O-11C-methyl-oxime ([11C]ABP688).
Methods: [11C]ABP688 PET was carried out in 15 individuals with
schizophrenia (6 female) and 15 healthy controls (6 female). Psychopathology in
cases and controls was assessed by the SCID-I, PANSS, BAI, BDI, and the Bern
Psychopathology Scale (BPS). In subjects with schizophrenia, antipsychotic
medication was transformed into chloropromazine equivalents. Exclusion criteria
comprised current psychiatric (for subjects with schizophrenia additional current
psychiatric disorders), medical, or neurological disorders, history of substance
dependence, pregnancy, and breastfeeding.
We applied a bolus/infusion protocol, previously evaluated for PET with [11C]
ABP688, which allows reliable measurement of the relative distribution volume
(DVR) and reduces potential bias due to arterial blood sampling needed for
absolute quantification. With this protocol equilibrium between the tracer in
tissue and blood is achieved 40 min after the start of radioligand infusion. A total
of 600–800 MBq of [11C]ABP688 in a 50-mL volume was administered using
an infusion pump. Individual dynamic uptake curves were checked for suitability.
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With Schizophrenia
Wednesday, Poster # 156 (continued)
Gregor Hasler*
PET data was analyzed with PMOD (Version 3.4, www.pmod.com, PMOD
Technologies, Zurich, Switzerland).
Results: Groups were age-matched (t28 = 0.172, p > 0.86): subjects with
schizophrenia were 38.2 ± 10.7 years old (mean ± standard deviation), healthy
controls were 37.5 ± 10.6 years old. Individuals with schizophrenia reported an
average illness duration of 15.6 ± 11.6 years with an illness onset at 22.6 ± 7
years. They were under stable medication with atypical neuroleptics (risperidone,
paliperidone, quetiapine, or clozapine) except for one subject who was treated
with fluanxol. Individuals with schizophrenia scored higher than healthy controls
in both BDI (t28 = 5.365, p < 0.001) and BAI (t28 = 2.648, p < 0.05).
No significant difference in mGluR5 DVR between subjects with schizophrenia
and healthy controls was found in a repeated measures analysis of variance with
12 brain regions as a within-subjects factor and diagnostic group as a betweensubjects factor (F(28,1) = 0.11; p > 0.9). Furthermore, no significant difference in
mGluR5 DVR between patients and controls was found when accounting for sex,
age, BDI scores, and BAI scores as covariates (F(24,1) = 0.082; p > 0.7). Adding
smoking status as a second between-subjects factor in the statistical model we
found a highly significant difference between smokers and non-smokers (F(22,1)
= 185.632; p < 0.0001) but no significant interaction between smoking and
diagnosis (F(22,1) = 0.320; p > 0.5).
We found a small potential effect of antipsychotic medication on mGluR5 DVR
levels in only one region, the medial orbitofrontal cortex (mOFC), and only for
non-smokers: higher chlorpromazine equivalent was associated with increased
mGluR5 DVR in the mOFC of non-smokers (rho = 0.9, p < 0.02). Focusing on
the same region we identified an interaction between diagnostic group and gender
(F(22,1) = 8.706; p < 0.01), as well a non-significant trend for a triple interaction
group-by-gender-by-smoking (F(22,1) = 3.884; p < 0.1). Schizophrenia was
associated with higher mGluR5 DVR in female non-smokers, but with lower
mGluR5 DVR in male non-smokers.
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With Schizophrenia
Wednesday, Poster # 156 (continued)
Gregor Hasler*
Within the schizophrenia group no significant correlations were found between
clinical and demographic variables and mGluR5 DVR (PANSS sum score p ≥
0.26; PANSS negative subscale p ≥ 0.49; PANSS positive subscale p ≥0.21;
PANSS general psychopathology subscale p ≥ 0.09; BPS language subscale p ≥
0.07; BPS affection subscale p ≥ 0.6; BPS motor subscale p ≥ 0.45; BDI p ≥ 0.24;
BAI p ≥ 0.15; onset of illness p ≥ 0.13; duration of illness p ≥ 0.05).
Conclusions: We did not find differences in mGluR5 binding between individuals
with schizophrenia and controls. Because antipsychotic drugs such as clozapine
appeared to affect mGluR5, our findings may be clinically relevant. They also
provide further insights into the high comorbidity between schizophrenia and
tobacco addiction, e.g., smoking may counteract the potential upregulation of
mGluR5 by antipsychotic drugs.
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Monday, Poster Board #123
Paolo Zanotti-Fregonara, Mattia Veronese, Rong Xu, Sami Zoghbi, Jeih-San
Liow, Masahiro Fujita, Victor Pike, Robert Innis*
NIMH
Background: One of the most important performance characteristics of a
positron emission tomographic (PET) radioligand is its ‘signal-to-noise’ ratio –
i.e., the amount of radioligand specifically bound to its target receptor compared
to that which adsorbs nonspecifically to proteins and lipids in brain. The typical
way to measure this ratio is to displace the specifically bound radioligand with
pharmacological doses of similarly binding drug and then measure the residual (or
nondisplaceable) uptake. Here, we describe a genomic method that can measure
the specific and nondisplaceable components of radioligand uptake based on the
relative regional density of the mRNA transcript of the target receptor but does
not require pharmacological blockade.
Methods: This genetic method was tested using brain imaging results from 12
healthy volunteers injected with tracer doses of 18F-FIMX, a radioligand we
recently developed to quantify metabotropic glutamate receptor 1 (mGluR1) (Xu
et al., J Med Chem, 56, 2013). Regional values of total brain uptake (VT) were
quantified with the ‘gold standard’ compartmental method that includes serial
concentrations of the parent radioligand (separated from radiometabolites) in
arterial plasma. The relative density of mGluR1 gene transcripts in brain regions
were obtained from the Allen Brain Atlas (Hawrylycz et al., Nature, 489:391,
2012). A modification of the Lassen plot was used to correlate some measure of
specific binding —in this case, the relative density of mGluR1 gene transcript—
with VT and then estimate the amount of nondisplaceable uptake (VND) by
extrapolating the value of VT when the specific binding equals zero (Cunningham
et al., J Cereb Blood Flow Metab, 30:46, 2010).
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Monday, Poster Board #123 (continued)
Paolo Zanotti-Fregonara, Mattia Veronese, Rong Xu, Sami Zoghbi, Jeih-San
Liow, Masahiro Fujita, Victor Pike, Robert Innis*
Results: Because gene transcript and expressed protein are not always linearly
related, we first performed a linear regression for multiple brain regions of the
mGluR1 gene transcript (y-axis) and VT (x-axis). The two variables were strongly
correlated (Pearson’s r = 0.965; p<0.0001). The x-intercept of this plot equalled
VND (0.5 mL • cm-3), as it was the residual value of VT when specific binding
was extrapolated to be zero. Because VND is usually the same for all brain
regions and even between species, we performed a standard receptor-blocking
study (using pharmacological doses of a related drug) in monkey and found a
similar VND value (0.6 mL • cm-3) after correcting for differences in plasma
protein binding of the radioligand.
Conclusions: Regional PET values of mGluR1 binding were strongly correlated
with mGluR1 transcript density; thus, the VND of the radioligand could be
estimated without pharmacological blockade, which is often impossible or even
dangerous to do in human subjects. Furthermore, because VND for this and most
PET radioligands is uniform throughout the brain, the specific binding—and thus
the “signal-to-noise” ratio—of this radioligand can be determined for all brain
regions. In addition to introducing a novel method to determine the receptorspecific component of radioligand binding, this study also shows how a publicly
available database (i.e., the Allen Brain Atlas) can be used to determine if a gene
transcript is linearly related to the expressed protein across brain regions for any
previously published PET radioligand. One common assumption of postmortem
studies of mRNA densities is that they reflect the density of the expressed protein.
This method can now test that assumption for targets that have been imaged with
PET. We are now studying several other targets measured with PET and are
finding, as might be expected, that gene transcript is sometimes, but not always,
correlated with the density of expressed protein.
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Response
Monday, Poster #78
Aaron Heller*, Tom Johnstone, Michael Peterson, Greg Kolden, Ned Kalin,
Richard Davidson
University of Miami
Background: Depression is a debilitating illness that causes suffering worldwide. There are many empirically supported treatments, but few biomarkers
predict whether an individual will improve. Developing biological tests to
predict treatment response across treatment approaches could facilitate improved
outcomes. In parallel, abnormalities in affective processing are core to depression.
The majority of neuroimaging work has examined the magnitude of neural
responses to emotion in depression, yet other affective neurodynamics may help
to characterize the illness and predict treatment response.
Methods: Thirty-nine unmedicated patients with major depressive disorder
were scanned using event-related fMRI in an emotional regulation paradigm.
Patients then received an eight-week trial of interpersonal psychotherapy (IPT),
venlafaxine or fluoxetine. Hamilton Rating Scale of Depression (HAM-D) was
collected pretreatment and at eight-weeks to assess symptom severity. To examine
whether affective neurodynamics predicted treatment response, we examined
the time-to-peak of fMRI BOLD activity in response to affective stimuli (IAPS
slides).
Results: Across all three-treatment types, a more rapid neural response in the
medial Prefrontal Cortex (mPFC) to both positive and negative emotional stimuli
predicted better treatment response (a greater drop in HAM-D). Furthermore, a
more rapid neural response in the amygdala to negative, but not positive stimuli
predicted a poorer outcome across treatments. Effects were significant when
controlling for pretreatment treatment HAM-D score so cannot be attributable to
initial severity. These effects were also significant when examining more traditional
neural markers such as the amplitude of fMRI BOLD activity indicating that
time-to-peak may be a unique neural biomarker predicting treatment response.
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Response
Monday, Poster #78 (continued)
Aaron Heller*
Conclusions: Across three separate treatments for depression (both psychotherapy
and pharmacotherapy), we found that a specific affective neurodynamic predicted
treatment response over an eight-week trial. These findings extend research that
has solely examined the magnitude of neural responding, in that rapid responses in
structures important for emotional regulation, such as the mPFC predicted better
treatment outcome. Conversely, rapid time-to-peak of subcortical areas, such as
the amygdala appeared to be maladaptive. Taken together, these data suggest that
regardless of treatment type, rapid engagement of regulatory circuits facilitate
treatment response while rapid engagement of subcortical emotional processing
areas may be disadvantageous.
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Impact of Chronic Ethanol Self-Administration on Kappa
Opioid Receptor Regulation of Dopamine Signaling in
Nonhuman Primates
Monday, Poster #256
Cody Siciliano*, Erin Calipari, Steven Fordahl, James Melchior, Jordan
Yorgason, Yolanda Mateo, Christa Helms, David Lovinger, Kathleen Grant,
Sara Jones
Wake Forest School of Medicine
Background: Although alcoholism is one of the most prevalent disorders in
the United States, with over 18 million individuals meeting the criteria for an
alcohol use disorder, the neurobiological bases of this condition remain obscure.
Recently, it has been demonstrated that kappa-opioid receptor (KOR) signaling
in the striatum plays a critical role in the increased reinforcing efficacy of ethanol
following ethanol vapor exposure in rodent models. However, changes in
KOR signaling following voluntary ethanol drinking remain to be elucidated.
Additionally, because numerous KOR agonists/antagonists are available clinically,
understanding how KOR sensitivity relates to drinking behaviors, especially in
nonhuman primate models of drinking, may open a novel avenue for therapeutic
interventions. Here we examined the effects of chronic voluntary ethanol selfadministration in macaques on dopamine neurotransmission and the ability of
KORs to regulate dopamine release in the nucleus accumbens core.
Methods: Three cohorts of nonhuman primates were given free access to 4%
ethanol (w/v) for 22 hr/day. These cohorts were composed of either male
cynomolgus, female rhesus or male rhesus macaques, and were given access to
ethanol for 6, 12, or 18 months, respectively. Ex vivo fast-scan cyclic voltammetry
was then conducted in brain slices containing the nucleus accumbens core to
determine ethanol-induced alterations in dopamine terminal function including
dopamine release and uptake kinetics as well as the ability of U50,488 (KOR
agonist) to inhibit dopamine release.
Results: Chronic ethanol drinking increased dopamine uptake rates, which could
have implications for reductions in basal dopamine tone in vivo following ethanol
drinking. Further, across sex, strain and exposure length ethanol consumption
augmented the ability of KORs to inhibit dopamine release, demonstrating that
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Impact of Chronic Ethanol Self-Administration on Kappa
Opioid Receptor Regulation of Dopamine Signaling in
Nonhuman Primates
ethanol-induced increases in KOR sensitivity are widespread and independent of
other factors. Finally, in male subjects KOR sensitivity was positively correlated
with lifetime ethanol intake, suggesting that changes in KOR regulation of
dopamine release may be a determinant of aberrant ethanol drinking behaviors.
Conclusions: Although it has been proposed that nonhuman primate models of
ethanol abuse represent the most promising avenue for elucidating the neurobiology
of alcoholism and for identifying molecular targets for pharmacotherapeutic
compounds, investigations have been largely limited to behavioral, endocrine
or brain imaging analyses due to practical constraints. Here we show, for the
first time, that voluntary ethanol self-administration has a unique effect on KOR
sensitivity and regulation of dopamine release directly at the dopamine terminal
that was positively correlated with drinking behavior. In conjunction with human
and rodent work, these data suggest that ethanol-induced dysregulation of the
dynorphin/KOR system may drive the motivation to administer ethanol, and thus
drive the development of addiction. The dynorphin/KOR system plays a large role
in regulating affective states in humans, and KOR agonists produce conditioned
place aversion in rodents. Thus, it is possible that supersensitivity of this system
may produce negative affective states, leading to increased consumption and
motivation to administer ethanol in an attempt to ameliorate these effects with
ethanol. Further supporting this hypothesis, dopamine uptake rates were also
increased, which could promote a state of low dopamine tone, which has also
been associated with anhedonia. Additionally, the relationship between KOR
sensitivity and drinking provides a potential mechanism for the comorbidity
of early life stress and alcoholism, as stress has been linked to increases in
dynorphin/KOR system activity in both animal and human investigations.
Together, these data provide novel insight into ethanol-induced dysregulation of
dopamine neurotransmission and suggest that dopaminergic dysfunction may be
mediating the increase in voluntary drinking during the early stages of ethanol
abuse/dependence. Importantly, KOR antagonists may provide a novel avenue to
reduce drinking behaviors in alcoholics.
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PL
Clifford Cassidy, Jared Van Snellenberg, Caridad Benavides, Mark Slifstein,
Zhishun Wang, Holly Moore, Anissa Abi-Dargham, Guillermo Horga*
Columbia University/NYSPI
Background: Research in the last decade has uncovered an intrinsic organization
of the brain into functional networks that operate partly in parallel during rest
and are thought to interact during complex cognitive processes such as working
memory, an interaction that may afford maintenance and manipulation of
perceptual information towards goal-directed actions. Understanding how brain
networks interact during cognition to facilitate flexible adaptations to changing
demands could provide new insights into the basis of interindividual differences
in working-memory performance and clarify the perplexing nature of the deficit
in working memory in schizophrenia. Dopamine is critical for working memory
processing in the cortex and elsewhere although it is not clear how dopamine
influences internetwork connectivity and whether such an action could mediate
its effects on working memory performance.
Methods: We addressed these questions in healthy volunteers (HV) with fMRI
(using an n-back working-memory task) and PET imaging using the radiotracer
[11C]FLB457 before and after amphetamine administration to measure the change
in binding potential (ΔBPND) of the radiotracer as an index of dopamine release
capacity in cortical and subcortical extrastriatal regions including thalamus,
midbrain, and hippocampus. MRI measures were available for 39 HV, 15 of whom
also had PET measures and for 15 unmedicated individuals with schizophrenia.
Brain networks were defined by group spatial independent component analysis
using GIFT software. Networks with working-memory-load-dependent activity
were selected for analysis of functional connectivity including left and right
fronto-parietal networks (lFPN, rFPN), cingulo-opercular network (CON) and
anterior default mode network (aDMN). Load-dependent connectivity between
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2:30 PM - 5:30 PM
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Guillermo Horga*
pairs of networks was determined via a modified psychophysiological interaction
analysis.
Results: For most pairs of networks, connectivity significantly changed with
working-memory load, particularly amongst subjects with good task performance
(5 of 6 pairs showed significant load-dependent connectivity, one-sample t-test,
p-value range: 0.00003-0.022). Working-memory performance (adjusted hit
rate in the higher load condition) was predicted by load-dependent connectivity
between lFPN and rFPN (∆ connectivity lFPN-rFPN; R2=0.30, standardized
β=0.55, p=0.0003) in a step-backwards regression including all network pairs; no
other network pairs predicted performance independently of this pair. Additional
step-backwards regressions found that working memory performance was
not predicted by the more conventional fMRI measures of load-independent
internetwork connectivity or load-dependent activation of individual networks.
Dopamine release capacity in subcortical, extrastriatal regions (but not in cortical
regions) was related to working memory performance (standardized β=0.55,
p=0.033) and also to ∆ connectivity lFPN-rFPN (standardized β=0.58, p=0.025).
Moreover, ∆ connectivity lFPN-rFPN fully mediated the relationship between
subcortical dopamine release capacity and working-memory performance
(Zab=2.61, p=0.009, bootstrap test for mediation). Compared to matched
controls, unmedicated individuals with schizophrenia did not significantly differ
in load-dependent connectivity but showed a significantly weaker relationship
between ∆ connectivity lFPN-rFPN and working-memory performance (group x
∆ connectivity interaction, standardized β=0.45, p=0.025). Furthermore, patients
showed a significant correlation between ∆ connectivity lFPN-rFPN and positive
symptoms measured with the SAPS (standardized β=-0.66, p=0.020).
Conclusions: Our findings indicate that interactions between brain networks
dynamically adapt to fluctuating environmental demands and that these dynamic
adaptations underlie successful working memory performance. Furthermore, we
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PL
Guillermo Horga*
provide evidence that this adaptive communication between brain networks could
also be a mechanism through which dopamine signaling influences working
memory performance. Such a mechanism would be consistent with dopamine’s
impact on synaptic efficacy, which could modulate the influence of projections
extending across networks thereby altering internetwork communication in
response to cognitive demand. Although cortical dopamine (which did not relate
to our measures of interest) is most commonly thought to modulate working
memory, our findings are consistent with previous evidence that dopamine
release in the thalamus may facilitate the maintenance of working memory
representations via thalamocortical loops while dopamine release in the midbrain
may affect working memory by regulating the dopamine system more generally.
Finally, the brains of patients with schizophrenia may not be properly exploiting
these dynamic network interactions in the service of adaptive behavior and that
psychotic symptomatology may relate to these network dynamics. In summary,
load-dependent internetwork connectivity likely underlies critical aspects of
cognitive processing related to dopamine and schizophrenia.
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in Early Illness Schizophrenia Patients and Individuals at
Clinical High Risk for Psychosis
Monday, Poster #163
Susanna Fryer*, Brian Roach, Katherine Wiley, Rachel Lowey, Judith Ford,
Daniel Mathalon
University of California at San Francisco
Background: Low-frequency oscillations (LFO) of the blood oxygen leveldependent (BOLD) signal assessed with resting state functional magnetic
resonance imaging (FMRI) are gaining interest as potential biomarkers sensitive
to neuropsychiatric pathology. Schizophrenia has previously been associated
with intrinsic LFO activity alterations that covary with cognitive deficits and
symptoms. However, the extent to which LFO activity dysfunction is present
prior to schizophrenia illness onset remains unknown. Accordingly, this study
examined the amplitude of resting LFO activity in youth at clinical highrisk (CHR) for psychosis, relative to healthy controls (HC) and early illness
schizophrenia patients (ESZ).
Methods: Resting-state FMRI data were collected from CHR (n=59), ESZ
(n=74), and HC (n=85) adolescents and young adults, ages 12-35. Age-adjusted
voxelwise fractional amplitude of low frequency fluctuations (fALFF) within the
.01 to .08 Hz frequency band of the BOLD signal was compared between the
three groups. Main effects of group (p<.005 height threshold, family-wise error
cluster-level corrected p<.05) were followed up via Tukey-corrected pairwise
comparisons.
Results: Significant main effects of group (height threshold, p<.005; cluster p
≤ .05) revealed decreased fALFF in ESZ and CHR groups relative to HC, with
values in the CHR group falling between those of ESZ and HC groups. These
differences were identified primarily in posterior cortex, including temporoparietal
regions, extending into occipital and cerebellar lobes. Furthermore, lower LFO
activity was related to higher symptom severity in CHR and ESZ groups (height
threshold, p<.005; cluster p ≤ .05).
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PL
in Early Illness Schizophrenia Patients and Individuals at
Clinical High Risk for Psychosis
Susanna Fryer*
Conclusions: These data support an intermediate phenotype of reduced posterior
cortical LFO amplitude in CHR individuals, with resting fALFF values smaller
than in HC but higher than in ESZ patients. Findings indicate that LFO activity
alterations, measured by fALFF, predate psychosis onset but are more pronounced
in the early stages of schizophrenia. Furthermore, these LFO abnormalities in
both CHR and ESZ groups are related to clinical symptoms.
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Monday, Poster #152
Thomas Weickert*, Jochen Kindler, Rhoshel Lenroot, Peter Schofield, Cynthia
Shannon Weickert
University of New South Wales
Background: People with schizophrenia show impaired response inhibition in
conjunction with decreased neural activity in the dorsolateral prefrontal cortex
(DLPFC). DLPFC activity during emotional response inhibition correlates
positively with circulating estrogen levels in healthy females and with circulating
testosterone in men with schizophrenia. Here, we tested the extent to which the
selective estrogen receptor modulator (SERM) raloxifene could modify neural
activity during a language-based emotional go/no-go task in men and women
with schizophrenia. We also predicted that the neural response to raloxifene
will vary depending on estrogen receptor alpha (ESR1) genotype in people with
schizophrenia.
Methods: Twenty-one men and women with schizophrenia participated in a
13-week, randomized, double-blind, placebo-controlled, crossover adjunctive
treatment trial of the SERM raloxifene administered orally at 120mg daily.
Effects of raloxifene versus placebo on brain activity were assessed using
functional magnetic resonance imaging (fMRI) during an emotional inhibition
test. Functional ESR1 genotype changes within intron 1 were determined by
TaqMan allelic discrimination assay.
Results: Relative to placebo, treatment with raloxifene increased neuronal
activity in the DPLFC during inhibition of negative words in men and women with
schizophrenia. The increased BOLD signal in the DLPFC was more pronounced
in ESR1 genotype that predicted higher ESR1 levels in the DLPFC. A separate
confirmatory Region Of Interest analysis comparing 21 people with schizophrenia
to 23 healthy controls demonstrated that raloxifene restores DLPFC activity to
normal levels in people with schizophrenia.
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PL
Thomas Weickert*
Conclusions: Selective estrogen receptor modulation by raloxifene facilitates
activation of the DLPFC during inhibition of negative emotions in men and
women with schizophrenia. People with schizophrenia having a specific ESR1
genotype displayed increased DLPFC activity during inhibition of emotional
words with raloxifene administration relative to those carrying the ESR1 risk
genotype. These results support a role for estrogen receptor modulation of
prefrontal neural activity in both men and women with schizophrenia and suggest
that ESR1 genotype may be informative of treatment response to raloxifene.
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Monday, Poster #79
Pascal Bonaventure*, Changlu Liu, Grace Lee, Diane Nepomuceno, Chester
Kuei, Jiejun Wu, Qingqin Li, Victory Joseph, Steve Sutton, William Eckert,
Xiang Yao, Lynn Yieh, Curt Dvorak, Carruthers Nicolas, Heather Coate, Sujin
Yun, Christine Dugovic, Anthony Harrington, Timothy Lovenberg
Janssen Research and Development
Background: G-protein coupled receptors (GPCRs) are among the most pursued
targets for drug development. More than 30% of the drugs currently on the market
target GPCRs yet, to date, they only affect a small proportion of all known GPCRs.
For this reason, orphan GPCRs represent an attractive source of new targets for
drug discovery research. GPR139 (aka GPRg1 or GPCR12) was identified as
a novel Rhodopsin GPCR having exclusive expression in the central nervous
system. A pharmacophore model based on known surrogate GPR139 agonists
was recently disclosed to propose L-tryptophan (L-Trp) and L-phenylalanine
(L-Phe) as putative endogenous ligands for GPR139 (Isberg et al., J. Chem. Inf.
Model, 2014, 54, 1553-1557). The goal of the present study was to identify the
physiological ligand for GPR139 using an experimental approach.
Methods: GPR139 receptor activity from recombinant cells following treatment
with amino acids, various orphan ligands as well as serum and tissue extracts
was measured using a guanosine 5’-O-(3-[35S]thio)-triphosphate binding assay.
Effects of the natural ligand on calcium mobilization and extracellular signalregulated kinases phosphorylation in recombinant systems were also tested. High
throughput screening was carried out to identify novel tool compounds to study
GPR139 function. A high affinity agonist was identified then radiolabeled and
used to develop a radioligand binding assay in membranes from cells transfected
with GPR139. GPR139 orthologues from various species were compared. RNA
sequencing was applied to study the expression of GPR139 in human and rat
central nervous system. The distribution of GPR139 was examined in greater
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PL
Pascal Bonaventure*
detail in the mouse brain using an antibody specific for GPR139 and by using beta
-galactosidase as a marker for GPR139 expressing cells in brains from GPR139
null lacZ knock-in mice. Lastly, a selective small molecule agonist and its less
active enantiomer were tested for their effects on spontaneous locomotor activity
in rats.
Results: The amino acids, L-Trp and L-Phe were both found to activate GPR139,
with EC50 values in the 30-300 uM range, consistent with the physiological
concentrations of L-Trp and L-Phe. Chromatography of rat brain, rat serum,
and human serum extracts revealed two peaks of GPR139 activity which
corresponded to the elution peaks of L-Trp and L-Phe. A selective small molecule
agonist (JNJ-63533054, (S)-3-chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)
benzamide) with low nM affinity and potency was identified. The tritium labelled
compound bound to GPR139 and could be specifically displaced by L-Trp and
L-Phe. Sequence alignment revealed that GPR139 is highly conserved across
species. RNA sequencing studies of rat and human tissues indicated its exclusive
expression in brain and pituitary gland. Immunohistochemical analysis showed
specific expression of GPR139 in circumventricular regions of the habenula and
septum in mice. The small molecule agonist but not its less active enantiomer
decreased spontaneous locomotor activity in rats.
Conclusions: In susceptible humans and in some animal models, reduced Trp
and Phe intake has been shown to be depressogenic, whereas anecdotal reports
of Trp and Phe loading are reported to have mood elevating affects. The effects
of altered Trp and Phe levels on behavior have been hypothesized to be mediated
by their downstream conversion to serotonin or dopamine. The localization
of GPR139 expressing neurons in circumventricular brain regions potentially
places the receptor in the correct position for sensing L-Trp and L-Phe levels
in circulating cerebrospinal fluid. Our findings suggest that L-Trp and L-Phe
49
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Pascal Bonaventure*
are likely physiological ligands for GPR139 which may underlie the biological
and behavioral effects of these substances without relying on their conversion to
biogenic amines. We hypothesize that this receptor may act as a sensor to detect
dynamic changes of brain L-Trp and L-Phe under physiological conditions.
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Notes
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Notes
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The Neuroscience of Sex Differences
Welcoming Remarks and Moment of Silence
Raquel Gur
President
Presentation of Honorific Awards
Peter Kalivas
Chair, Honorific Awards Committee
JOEL ELKES
ACNP First President
Joel Elkes was born in Koenisberg, Eastern Prussia on November 12, 2013 and
died in Sarasota, Florida on October 30, 2015. Recognized by many as a worthy
successor to Thudichum and father of modern Neuropsychopharmacology, he
was a founding member of ACNP and first President in 1961. The Joel Elkes
Research Award was established by the College in 1986, to recognize exceptional
clinical contributions to psychopharmacology. Since 1986, the award has been
granted to 28 deserving earlier career researchers, including three, who later went
on to become ACNP president.
Raised in Kovno, capital of Latvia, his parents were Jewish, his father an inspiring
physician role model. Before World War II Joel moved to England for medical
school but his father remained and tragically became a victim of the Holocaust.
Joel’s research began as a Student Demonstrator in Physiology at Saint Mary’s
Hospital in London. Later he began a psychoanalysis at the Tavistock Clinic,
disrupted by war, and completed twenty years later in Washington, D.C. At
graduation he moved to Birmingham as a research fellow in Pharmacology,
obtained his doctoral degree and progressed to Acting Chair of the Department
in eight years, simultaneously educating himself in psychiatry at the local mental
hospital.
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Following a Fulbright Fellowship in America he returned to become Chair of
the Department of Experimental Psychiatry in Birmingham, establishing an
international reputation in neuroscience and pharmacology, conducting the
first double-blind study of chlorpromazine and convening the first International
Neurochemical Symposium at Oxford.
In 1957 Joel moved to Washington, D.C. to become Chief of Neuropharmacology,
Behavioral and Clinical Studies for the NIMH center at St.Elizabeth’s Hospital.
This began a six year ‘Camelot” period; “It was a wonderful, heady exciting time
in the middle of a chronic mental hospital.”
In 1963 Joel moved to Johns Hopkins to Chair a program he renamed, “The
Department of Psychiatry and Behavioral Sciences.” His integrative style
produced a wealth of initiatives, including an early M.D.-Ph.D. program, a
residential care facility for people with mental illness and a Masters’ Program for
Mental Health Counsellors.
After ending his formal career at Hopkins in 1974 as a Distinguished Emeritus
Professor what lay ahead were thirty years of continuing activity, first as a Professor
in Residence at McMaster University in Canada and then as Distinguished
Emeritus Professor at Louisville University where his interests blossomed into
innovative programs designed to humanize medical education and integrate the
cultures of Art and Medicine.
Joel finally came to rest in Sarasota where he met and married his beloved
wife Sally, an idyllic relationship bonded by mutual interests in art, education,
mindfulness and social justice. His artistic talent flowered in an oeuvre attracting
the attention of institutions and art critics, “In a threatened society Joel Elkes
creates beautiful images to lighten the soul.”
The manner in which Joel Elkes manifested his talents is elegantly expressed by
Tom Ban in a book he co-edited to celebrate Joel’s centennial birthday. “Elkes
through his professional activities put the behavioral sciences in the service of
medicine and art in the service of healing; a unique message to that place in the
listener’s heart where ‘meaning’ and ‘hope’ meet.
Source Materials:
Ban TA. Forward in “Selected Writings of Joel Elkes” Ed. Ban TA. Budapest, Animula, 2001
Blackwell B. Joel Elkes: An integrative life. On INHN.org in Biographies. 8.20.2015.
Elkes J. Interview with Fridolin Sulzer in “The Oral History of Neuropsychopharmacology”
Vol. 1, p. 221 et seq. (Series Ed. Ban TA, Volume Ed.Shorter E). ACNP, 2011.
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The Neuroscience of Sex Differences
8:30 AM
Sex-Specific Regulation of Synaptic Function in the
Hippocampus
Catherine Woolley
PL
9:15 AM
Sex Biased Stress Signaling
Rita Valentino
10:00 AM
Sex Influences on Brain and Body: An Issue Whose Time Has
Come
Larry Cahill
10:45AM
Sex and the Brain from Fetal Development Through Aging:
Impact on Psychopathology and Therapeutics
Jill Goldstein
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PL
Sex-Specific Regulation of Synaptic Function in the
Hippocampus
Catherine Woolley
Northwestern University
Many neuropsychiatric disorders vary between the sexes in their incidence,
symptoms, or responses to treatment. The degree to which this variation arises
from differential experience versus intrinsic biological sex differences is unclear.
In studies with adult male and female rats, we have found intrinsic biological sex
differences in mechanisms of synaptic modulation in the hippocampus, a brain
region important in learning and memory, affective behaviors, and in epilepsy.
Many of our studies use acute estradiol application to hippocampal slices as a
model for neurosteroid estrogen actions in the brain. Neurosteroid estrogens are
produced in the hippocampus of both sexes. We find that estradiol regulates
both excitatory and inhibitory synapses in the hippocampus, but differentially in
males and females. Acute estradiol-induced suppression of inhibitory synaptic
transmission is sex-specific, occurring only in females. Acute estradiol-induced
potentiation of excitatory synaptic transmission occurs in both sexes, but through
different mechanisms in each sex. Understanding the molecular mechanisms
that underlie sex-dependent estradiol modulation of synaptic function in the
hippocampus may reveal mechanisms through which experiences or interventions,
such as drugs, affect males and females differently.
Catherine S. Woolley is William Deering Chair in Biological Sciences and
Professor of Neurobiology at Northwestern University in Evanston, IL. She
obtained her PhD from Rockefeller University in 1993, completed postdoctoral
training at the University of Washington, and moved to Northwestern in 1998.
Her research focuses on steroid modulation of synaptic structure and function in
the adult brain, particularly in the hippocampus, with the aim of understanding
how steroids influence hippocampus-dependent behaviors and neurological
disorders that involve the hippocampus.
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Rita Valentino
PL
The Children’s Hospital of Philadelphia
A major challenge in psychiatry is to identify the neurobiological bases for
sex differences that exist in disease prevalence and severity and in responses
to psychopharmacological agents. Stress-related psychiatric disorders are
particularly more common in females compared to males. Findings from
physiological, molecular and cellular studies support the idea that sex biases
in signaling and trafficking of the receptor for the stress-related neuropeptide,
corticotropin-releasing factor (CRF), underlie enhanced female vulnerability to
stress-related psychiatric disorders. Physiological studies provided evidence for
increased neuronal sensitivity to CRF in females. Molecular and cellular studies
identified sex differences in the association of the CRF receptor (CRF1) with the
Gs protein and b-arrestin 2 that render females more responsive to CRF and acute
stress and less able to adapt to chronic stress as a result of compromised CRF1
internalization. Because b-arrestin 2 links CRF1 to Gs-independent signaling
pathways, CRF1 can be characterized as “sex biased” whereby the same agonist
can engage different signaling pathways in males and females. This sex biased
signaling could potentially initiate distinct cellular responses to stress that are
translated to different physiological and behavioral coping mechanisms and that
can have different pathological consequences. Because sex-biased signaling
should lead to different profiles of phosphorylation in males and females, a
systems biology approach of phosphoproteomics was used as a proof of principle
and also to predict the potential pathophysiological impact of sex biased CRF1
signaling. The initial results suggest that this sex bias may favor pathways related
to Alzheimer’s disease pathology in females. The possibility that analogous sex
differences may occur with other G-protein coupled receptors underscores the
wide impact of this effect. Supported by PHS MH 040008 and MH 093981.
Rita J. Valentino, Ph.D. is a Stokes Investigator at the Children’s Hospital of
Philadelphia and Professor and Director of the Division for Stress Neurobiology
in the Departments of Anesthesiology and Critical Care Medicine at Children’s
Hospital of Philadelphia and the University of Pennsylvania. Dr. Valentino
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PL Rita Valentino (continued)
received her Ph.D. in Pharmacology from the University of Michigan in 1980.
She completed postdoctoral training at the University of North Carolina (198081) and at the Salk Institute (1982-83) for Biological Studies. She formerly served
on the faculty of George Washington University (1983-89) and Hahnemann
University (1989-2000).
Dr. Valentino’s research on the regulation of monoamine systems by the
stress neuropeptide, corticotropin-releasing factor (CRF), have advanced our
understanding of the mechanisms by which stress increases vulnerability to the
many stress-related diseases including mood disorders, substance abuse and
Alzheimer’s disease. Her integrated systems approaches have also revealed brainperipheral communication underlying certain psychiatric and medical disorders
comorbidities. Dr. Valentino’s laboratory made the novel discovery that CRF
receptor coupling to signaling molecules and CRF receptor trafficking exhibit
sex differences. Her recent work is showing how sex-biased CRF signaling can
account for increased vulnerability of females to certain stress-related disorders.
Dr. Valentino was the recipient of an NIMH Established Investigator Award and
a NARSAD Distinguished Investigator Award. Her research has been funded
since 1983 by NIMH, NIDA, NIDDK, NSF, DARPA, and the American Heart
Association. Dr. Valentino has dedicated much of her time to service in the
scientific community. She is currently on the Program committee for the Society
for Neuroscience. She is a member of the Scientific Advisory Board for the
Brain and Behavior Research Foundation (formerly NARSAD). She currently
serves on the ACNP Council, Women’s Task Force and Chairs the Committee
on Ethics. She is a regular member of the American Society for Pharmacology
and Experimental Therapeutics and currently serves as a Member-at-Large
for the Neuropharmacology Executive Committee. She has been a regular
member of grant review panels starting with NSF from 1988-1991, the NIH
Behavioral Neuroscience Review IRG from 1992-1994, the Neuropharmacology,
Neurochemistry Committee IRG from 1994-1997 and the Pathophysiological
Basis of Mental Disorders and Addiction IRG from 2008-2013 serving as Chair
from 2011-2013. She is Chief Editor of “The Neurobiology of Stress”.
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Sex Influences on Brain and Body: An Issue Whose Time Has
Come
PL
Larry Cahill
University of California, Irvine
Long confined to a corner of neuroscience concerned only with reproduction, the
issue of sex influences on brain function is rapidly moving center stage, driven
by a surge of research findings proving that subject sex can, and regularly does,
alter research findings, hence conclusions, at every level of brain function down
to the molecular level. The inexorably rising recognition of this fact means that
the issue of sex influences on brain function is an issue whose time has come.
Dr. Larry Cahill is a Professor in the Department of Neurobiology and Behavior
at the University of California, Irvine. He first became interested in brain and
memory as an undergraduate at Northwestern University. After working for two
years at Searle Drug Company in Illinois on memory enhancing drugs, he earned
his Ph.D. in Neuroscience from the University of California at Irvine in 1990,
then conducted post-doctoral research in Germany for 2 years. He returned to
UC Irvine to extend his research to studies of human subjects, which in turn led
to his discoveries about sex influences on emotional memory, and to his current
general interest in the profoundly important issue of sex influences on brain and
body function.
He is a long-standing leader in the area of brain and memory, and more recently
has become an influential leader on the topic of sex influences on the brain. He
is an internationally regarded investigator and speaker whose work has been
highlighted extensively in the press, including in the New York Times, London
Times, Washington Post, Frankfurter Allgemeine Zeitung, PBS, CNN and 60
Minutes.
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PL
Jill Goldstein
Harvard Medical School/Brigham & Women’s Hospital
Sex differences in the incidence of psychiatric disorders are pervasive. Although
these sex differences have been known for many years, neurobiological
mechanisms to explain them are still unclear. There is substantial preclinical
literature on the development of sexual dimorphisms of the brain. However, there
is much less known about how disruptions of sex differences in healthy human
brain development contribute to producing adult psychopathology and how this
impacts therapeutic response. There has been a renewed interest in these issues
with increasing public awareness and a new NIH focus as to the importance of
understanding sex differences in the brain. The program of research under my
direction is called the Clinical Neuroscience Laboratory of Sex Differences in the
Brain (http://cnl-sd.bwh.harvard.edu) consisting of interdisciplinary investigators
integrating brain imaging with psychophysiology, neuroendocrinology,
genetics, markers of immune function, and collaborative efforts with preclinical
investigators studying genes, hormones, and the brain. Specifically, we are
investigating prenatal stress-immune models (i.e., fetal programming) of sex
differences in major depressive disorder, schizophrenia, memory circuitry aging,
and comorbidity of these disorders with general medical disorders, such as
cardiovascular disease. The ability to regulate the “stress response” is critical for
the adaptive needs of an organism providing a mechanism for creating physiologic
homeostasis and functional ability. It is developmentally established, expressed
differentially by sex, and disrupted in numerous psychiatric disorders. We believe
that understanding these pathways will provide insights into the shared nature
of sex differences in the disorders we study. Included in our work, we have
been following a prenatal cohort over the last 20 years (initiated in 1959-1966
following pregnant mothers and their offspring for 7 years). We analyzed maternal
prenatal sera (stored at NIH for 40 years) and re-recruited her offspring as 4050 year old adults phenotyping them clinically and cognitively, and conducting
structural and functional brain imaging, with serologic work evaluating steroid
hormones, immune function, and genetics. This allows us to study, in vivo, the
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Jill Goldstein (continued)
fetal programming of adult onset diseases. We believe an understanding of the
hormonal and genetic pathways implicated in sex differences in the brain will
provide knowledge for the development of sex-dependent therapeutics, which
will be discussed.
Jill M. Goldstein, Ph.D., a clinical neuroscientist, is Professor of Psychiatry and
Medicine at Harvard Medical School and Director of Research at the Connors
Center for Women’s Health and Gender Biology at Brigham and Women’s
Hospital. Over the past 28 years, Dr. Goldstein has become an international
leader in characterizing sex differences in the development and adult functioning
of the human brain and how these differences contribute to understanding sex
differences in psychiatric disorders and their comorbidity with general medical
disorders. Her program of research, called the Clinical Neuroscience Laboratory
of Sex Differences in the Brain (http://cnl-sd.bwh.harvard.edu), integrates brain
imaging with psychophysiology, neuroendocrinology, genetics, and markers of
immune function. Brain circuitries under investigation include the stress response
circuitry, memory and working memory (and aging of memory circuitry),
and reward circuitry implicated in obesity. Investigations focus on prenatal
stress-immune pathways and the risk for sex differences in depression and its
comorbidity with CVD, psychoses, and memory circuitry aging and risk for
Alzheimer’s disease. She has received numerous grants to support this work and
written numerous publications on these topics. She was named the 2007 Spinoza
Professor by the Academic Medical Center, University of Amsterdam, for her
work on the impact of sex differences in the brain for understanding medical
disorders, and received the 2015 Distinguished Scientist Award from the National
Association for Research on Schizophrenia and Depression. Dr. Goldstein is also
a leader in training the next generation of women and men in women’s health
and sex differences in medicine, as reflected in being P.I. of an ORWH-NICHD
Harvard K12 training program on Building Interdisciplinary Careers in Women’s
Health (BIRCWH) called, “Hormones and Genes in Women’s Health: From
Bench to Bedside”.
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Data Blitz
PL 11:30 AM
Retrieval of Positive and Negative Associations Produces
Opposite Responses in BLA Neurons Projecting to NAc and CeA
Anna Beyeler
11:40 AM
Deficits in Striatal Dopamine Release in Cannabis Dependence
Jodi Weinstein
11:50 AM
Role of Locus Coeruleus-Ventral Tegmental Area Circuit in
Mediating the Resilience to Social Stress
Hongxing Zhang
12:00 PM
[11C]Neuroflux: In Vivo Measurement of Neuron Population
Flux
Genevieve Van de Bittner
12:10 PM
Modeling Cognitive Therapy in Rats: Fear Extinction Reverses
the Chronic Stress-Induced Shift From Active to Passive Coping
Behavior
Elizabeth Fucich
12:20 PM
Phosphatidylcholines (PCs) in Major Depressive Disorder: A
Plasma-Based Endophenotype Related to Inflammation
Emma Knowles
12:30 PM
Input and Output-Specific Regulation of a Learned Action
Sequence by Corticostriatal Circuits
Patrick Rothwell
12:40 PM
Inflammation and Memory: Associations Among the CRP Gene,
Serum CRP, and Memory Performance
Negar Fani
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Data Blitz
PL
12:50 PM
Abnormal Fucosylation-Associated Enzyme Expression in
Schizophrenia
Toni Mueller
1:00 PM
Ketamine Induced NMDA-Receptor Blockade and Hippocampal
Glutamate in Healthy Volunteers
Nina Kraguljac
1:10 PM
Cariprazine as Monotherapy for the Treatment of Predominant
Negative Symptoms of Patients With Schizophrenia: A DoubleBlind, Active Comparator-Controlled Trial
Rene Kahn
1:20 PM
Paternal Cocaine Exposure Elicits Learning Deficits in Male
Progeny
Mathieu Wimmer
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PL
Monday, Poster #119
Anna Beyeler*, Praneeth Namburi, Gordon Glober, Clémence Simonnet, Garret
Conyers, Robert Luck, Craig Wildes, Kay Tye
MIT
Background: The valence of our emotions guide our daily life, allowing us to
produce adaptive behaviors in order to ensure our survival and well-being. The
amygdala, and more specifically the basolateral amygdala (BLA) is necessary for
processing negative valence (fear conditioning) and has more recently be shown
to be involved in positive valence conditioning (reward seeking). However, very
few studies describe how BLA neurons encode valence and the downstream
targets of these neurons remain unknown.
Methods: By combining optogenetic photo-identification of BLA neurons
with a specific projection target and large scale electrophysiological recordings
in behaving mice, we tested whether BLA neurons projecting to different
downstream target encode valence differentially. After mice learned to associate
an auditory cue with a rewarding outcome (sucrose delivery), and a second tone
with an aversive outcome (quinine delivery), we recorded BLA neurons while the
animals were performing the task.
Results: By combining optogenetic photo-identification of BLA neurons with
a specific projection target and large scale electrophysiological recordings
in behaving mice, we tested whether BLA neurons projecting to different
downstream target encode valence differentially. After mice learned to associate
an auditory cue with a rewarding outcome (sucrose delivery), and a second tone
with an aversive outcome (quinine delivery), we recorded BLA neurons while the
animals were performing the task. Amongst the 1570 single units we recorded in
the BLA, 56% responded to cues of positive and/or negative valence. Units photoidentified as projecting to the nucleus accumbens (60 NAc projectors, n=8 mice)
were either 1) selectively excited by cues of positive valence, or 2) selectively
inhibited by cues of negative valence, or 3) inhibited by both cues. Conversely,
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PL
Anna Beyeler*
BLA neurons projecting to the central amygdala (66 CeA projectors, n=6 mice)
were either 1) selectively excited by cues of negative valence, or 2) selectively
inhibited by cues of positive valence, or 3) excited by both cues. On the other
hand, the population of BLA units photo-identified as projecting to the ventral
hippocampus (31 vHPC projectors, n=3 mice) showed a similar distribution of
responses compared to the entire BLA population.
Conclusions: These results support a model of dynamic valence coding during
expression of valence discrimination where NAc and CeA projectors provide
valence specific excitation to their downstream target during cues of positive and
negative valence, respectively, and are inhibited during cues of opposite valence.
The mutually exclusive pattern of coding of the NAc and CeA projectors also
suggests that these two populations are part of a microcircuit allowing reciprocal
inhibition.
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PL Monday, Poster #262
Elsmarieke van de Giessen, Jodi Weinstein*, Clifford Cassidy, Margaret Haney,
Zhengchao Dong, Rassil Ghazzaoui, Najate Ojeil, Lawrence Kegeles, Xiaoyan
Xu, Nehal Vadhan, Nora Volkow, Mark Slifstein, Anissa Abi-Dargham
Columbia College of Physicians and Surgeons
Background: Most drugs of abuse lead to a general blunting of dopamine release
in the chronic phase of dependence, which contributes to poor outcome. To test
whether cannabis dependence is associated with a similar dopaminergic deficit,
we examined striatal and extrastriatal dopamine release capacity in severely
cannabis dependent participants (CD), free of any comorbid conditions, including
nicotine use.
Methods: Eleven CD and twelve healthy controls (HC) completed two
positron emission tomography scans with [11C]-(+)-PHNO, before and after
oral administration of d-amphetamine. CD stayed inpatient for 5-7 days prior
to the scans to standardize abstinence. Percent change in [11C]-(+)-PHNO
binding potential (ΔBPND) was compared between groups. Magnetic Resonance
Spectroscopy (MRS) measures of glutamate in the striatum and hippocampus
were obtained in the same subjects on the day prior to PET. Correlations with
MRS glutamate, subclinical psychopathological and neurocognitive parameters
were examined.
Results: CD had significantly lower ΔBPND in the striatum (p=0.002, effect
size (ES)=1.48), specifically in the associative striatum (p=0.003, ES=1.39) and
sensorimotor striatum (p=0.003, ES=1.41), as well as in the pallidum (p=0.012,
ES=1.16). Lower dopamine release in the associative striatum correlated with
inattention and negative symptoms in CD, and with poorer working memory and
probabilistic category learning performance in both CD and HC. No relationships
to MRS glutamate were detected.
Conclusions: This study provides definitive evidence that severe cannabis
dependence- without the confound of any comorbidity- is associated with a
deficit in striatal dopamine release. This deficit extends to other extrastriatal areas
and predicts severity of subclinical psychopathology and reduced neurocognitive
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Jodi Weinstein*
performance. Future studies should investigate the significance of this pattern
for the behavioral effects of cannabis, especially in terms of increasing the
vulnerability to psychosis.
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PL
Monday, Poster # 209
Hongxing Zhang*, Dipesh Chaudhury, Barbara Juarez, Allyson Friedman, Stacy
Ku, Alexander Nectow, Marshall Crumiller, Cheng Jiang, Song Zhang, Carole
Morel, Stephen Salton, Jeffrey Friedman, Jun-Li Cao, Ming-Hu Han
Icahn School of Medicine at Mount Sinai
Background: Rather than a simple lack of pathological alterations in the brain,
resilience is an active stress-coping process. Understanding the mechanisms
underlying resilience could provide us with novel therapeutic targets for the
treatment of depression, among other stress-related psychiatric disorders.
Emerging evidence has implicated the role of locus coeruleus-norepinephrine
(LC-NE) system in stress resilience. It is widely known that the LC-NE nucleus
globally primes neurons in the brain to be responsive to stimuli. However,
knowledge regarding circuit-specific LC-NE mechanisms of resilience is
lacking. Taking advantage of circuit-probing electrophysiological, optogenetic,
and molecular profiling approaches, we explore the function of LC-NE neurons
projecting to the ventral tegmental area (VTA), a key nucleus involved in the
segregation of resilient and susceptible phenotypes (Krishnan V et al., Cell 2007;
Chaudhury D., Nature 2013).
Methods: In this study, we employed a 10-day chronic social defeat stress (CSDS)
paradigm to segregate resilient and susceptible behavioral phenotypes in C57BL/6J
mice. After the 10-day CSDS procedure, mice were divided into susceptible or
resilient phenotypes based on social interaction scores. Utilizing a retrograde
lumaflour, we visualized LC neurons projecting to the VTA (LC-VTA neurons),
and recorded their firing activity in the LC slice preparations from stress-naïve
control, susceptible, and resilient mice. To investigate the relationship between
firing alterations of LC-VTA neurons and behavioral outcomes, we utilized a
combination of viral and optogenetic techniques. Specifically, we injected
retrograde AAV2/5-Cre in the VTA and AAV5-DIO-ChR2 in the LC to selectively
express ChR2. We then delivered optical stimulation to LC-VTA neuron bodies
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Monday, Poster # 209 (continued)
Hongxing Zhang*
of test animals (20 minutes per day for 10 days). To investigate the postsynaptic
adrenoceptors involved in the VTA, we focused on the VTA dopamine neurons
projecting to the nucleus accumbens (VTA-NAc), a subpopulation of VTA
dopamine neurons known to display active neuroadaptations in resilient animals
(Friedman AK et al., Science 2014). Utilizing a circuit-mapping molecular
profiling approach (Ekstrand MI et al., Cell 2014), we injected CAV-GFP into the
NAc and AAV-FLEX-NBL10 into the VTA of DAT-IRES-Cre or TH-Cre mice
and screened potential adrenoceptor subtypes in VTA-NAc dopamine neurons
with immunoprecipitation.
Results: Our electrophysiological recordings from lumaflour+ LC-VTA neurons
showed that the baseline firing activity of these neurons was significantly
elevated in resilient mice, when compared to control and susceptible mice. In
contrast, we found these neurons to have comparable firing rates in susceptible
and stress-naïve mice. Next, to determine whether increasing the firing activity
of the LC-VTA circuit promotes resilient behaviors in previously defined
susceptible mice, we selectively expressed ChR2 in LC-VTA neurons, as stated
above. We found that 10-day repeated optogenetic activation (20 minutes/day)
of LC-VTA neurons in susceptible mice reversed social avoidance behaviors.
Surprisingly, the same 10-day repeated optical stimulation of LC-VTA neurons in
susceptible mice normalized the pathophysiological hyperactivity and induced a
new homeostatic balance between excitatory hyperpolarization-activated cation
channel current (Ih) and inhibitory potassium (K+) currents, an active adaptation
signature seen in the VTA-NAc dopamine neurons of resilient mice. Using a
circuit-mapping molecular profiling technique, we screened the molecular targets
of LC noradrenergic inputs on VTA-NAc dopamine neurons and found a higher
expression of α1b and β3 adrenoceptors in VTA-NAc dopamine neurons, when
compared to overall VTA dopamine neurons. To further confirm these receptors’
role in mediating resilience mechanisms, we repeatedly infused a cocktail of
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Hongxing Zhang*
methoxamine hydrochloride (α1 agonist) and CL316243 (β3 agonist) into the
VTA for 10 days and found a potent reversal of social avoidance behaviors, which
is consistent with the 10-day optical stimulation-induced effects.
Conclusions: These circuit-specific investigations support the notion that LCVTA neurons play an important role in mediating the resilience mechanisms.
Specifically, the electrophysiological and optogenetic studies demonstrate that
activation of LC-VTA neurons promotes the active ion channel and cellular
homeostasis in VTA-NAc dopamine neurons. Moreover, the molecular profiling
and pharmacological examinations reveal that α1b and β3 receptors mediate
interactions between the LC-NE system and the VTA reward circuit. Taken
together, our findings not only elucidate a novel resilient neural circuit in the brain,
but provide a new molecular target for developing treatments for depression.
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Flux
PL
Monday, Poster #146
Genevieve Van de Bittner*, Misha Riley, Luxiang Cao, Janina Ehses, Scott
Herrick, Emily Ricq, Jaclyn Smith, Changning Wang, Frederick Schroeder,
Mark Albers, Jacob Hooker
Harvard Medical School/MGH
Background: Neuron population flux is the longitudinal alteration in a neuron
population as a result of net neuron influx or efflux. Neurodevelopmental and
neurodegenerative diseases often result in aberrant neuron flux that, if measured,
could be a biomarker of disease progression or disease treatment efficacy.
Regions with the highest neuron turnover are ideally targeted for measurements
of neuron population flux due to their dynamic state, as changes in neurogenic
or neuron death rates will be apparent more quickly. The tissue with the highest
rate of adult neuron turnover is the olfactory epithelium (OE), which contains the
olfactory sensory neurons (OSNs) that provide the sensory input for our sense of
smell. Across lifespan, the OSN proliferation rate is several hundred to several
thousand fold higher than that found in the subgranular zone of the dentate
gyrus, making it the ideal candidate for monitoring neuronal population flux. To
measure flux, longitudinal measurements of the neuron population are required;
thus, we focused on non-invasive imaging techniques that offer the possibility for
repeat measurements within individual subjects. We selected positron emission
tomography (PET) due to its biological target selectivity, human translational
potential, and capacity for quantitative comparisons. We developed a novel
neuron-population-monitoring PET radiotracer, [11C]neuroflux, and applied it
to biological models to demonstrate its facility for neuron flux monitoring and
highlight its diagnostic potential.
Methods: After we synthesized and validated [11C]neuroflux, it was utilized in
several rodent models through intravenous administration, 60 minute dynamic
PET scans, and Logan image analysis. Ex vivo evaluation of the OSN population
in all animal models was achieved with Western Blot (WB) of the olfactory marker
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PL
Flux
Genevieve Van de Bittner*
protein (OMP), which is selectively expressed in the OSNs. The animal models
studied include: 1) olfactory bulbectomy 2) stimulus-induced neurogenesis, 3)
normative post-natal development, 4) normative aging, and 5) a neurodegenerative
tauopathy model. The olfactory bulbectomy model was chosen for its welldocumented ability to selectively remove mature OSNs from the OE, resulting
in net neuron efflux. In this study, we completed unilateral and bilateral olfactory
bulbectomies on groups of WT mice with [11C]neuroflux imaging after 2-3 days.
To model the reciprocal process of neurogenesis, we utilized intranasal zinc
sulfate treatment, which strips the OSNs from the OE, resulting in a neurogenicpredominant state for OSN replenishment. This model is differentiated from the
bulbectomy model because newly born neurons are able to mature by forming
axonal connections with the intact olfactory bulb. Subsequently, normative
alterations in neuron population flux were monitored, beginning with post-natal
neuron population development. This was achieved through [11C]neuroflux
imaging of 1.3, 2, 3, 5.5, 9 and 12 month old rats, including tracking individual
rats between 5.5 and 12 months of age. Turning to aging-induced neuron death,
we imaged cohorts of 7, 12, and 23 month old mice with [11C]neuroflux. To
highlight the disease diagnosis potential for [11C]neuroflux imaging, we moved
to a murine tauopathy neurodegeneration model, rTg4510, which reproduces
many of the features of Alzheimer’s disease and frontotemporal dementia. [11C]
Neuroflux imaging was completed in 3.7 and 7 month old rTg4510 animals and
age-matched controls.
Results: Exploiting olfactory bulbectomy and zinc sulfate models, which
respectively produce OSN death and OSN neurogenesis, we validated [11C]
neuroflux imaging for sensitive monitoring of the complete neuron efflux-influx
cycle. A switch to the assessment of [11C]neuroflux imaging in animal models
of normative development and aging reproduced the anticipated neuron growth
curve that predominates into early adulthood; thereafter, [11C]neuroflux imaging
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Flux
PL
Genevieve Van de Bittner*
monitored the neuron efflux resulting from aging-induced neuron death. This
study displayed the sensitivity of [11C]neuroflux to normative OSN population
changes, supporting the capacity for [11C]neuroflux imaging to measure
neuron flux during disease. This hypothesis was validated through successful
stratification of control and tauopathy (rTg4510) mice by [11C]neuroflux at early
stages of the disease, prior to neuronal loss in the cortex. Additional validation of
all animal models through ex vivo WB analysis of OMP levels recapitulated the
[11C]neuroflux imaging results for each model.
Conclusions: Our novel [11C]neuroflux radiotracer monitors changes in
neuron flux resulting from altered neurogenic and neuron death rates. Based
on initial studies, there are expected applications for early neurodegenerative
disease diagnosis as well as monitoring the in vivo, longitudinal efficacy of
novel neuroprotecive therapeutics. Of note, a recent study on human olfactory
dysfunction indicates that loss of smell predicts 5-year mortality in older adults,
a result that may be correlated with neuron efflux from the olfactory tissue. This
highlights the potential contribution of OSN flux imaging to the understanding of
human mortality.
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PL Behavior
Monday, Poster #23
Elizabeth Fucich*, Madeleine Saunders, David Morilak
University of Texas Health Science Center at San Antonio
Background: Stress-related psychiatric disorders, like depression or posttraumatic stress disorder (PTSD), are highly prevalent yet poorly treated.
These disorders share many dimensions, including cognitive flexibility deficits
associated with hypoactivity in the medial prefrontal cortex (mPFC), and
maladaptive avoidant coping strategies, which may also be modulated by mPFC
activity. Psychotherapies that invoke mPFC activity can be efficacious even in
pharmacotherapy-resistant patients, although, as with pharmacotherapies, the
response to psychotherapy can be incomplete, some patients do not respond, and
relapse remains an issue. Identifying the neurobiological mechanisms underlying
its efficacy could lead to more rapid, efficacious, or long-lasting treatments. Preclinically, chronic unpredictable stress (CUS) induces cognitive inflexibility and
a shift from active to passive coping behavior in rats, similar to the cognitive
inflexibility and avoidant coping seen in patients with stress-related psychiatric
illness. We have previously shown that the extinction of conditioned fear, which
engages the mPFC and closely resembles prolonged exposure therapy used
for PTSD treatment, can model cognitive behavioral therapy (CBT) in rats by
improving their performance in a test of cognitive flexibility, and restoring active
coping behavior in the shock probe defensive burying (SPDB) test, that have
been compromised by chronic stress (SfN Abstract 468.07, 2014). In this study,
we tested the hypothesis that mPFC activity during extinction is necessary for
its beneficial effect in reversing the CUS-compromised coping behavior in the
SPDB.
Methods: Fos immunohistochemistry was used to demonstrate activation of the
mPFC by extinction, with dual labeling of cell type-specific markers to identify
mPFC cell types that were activated. To test the necessity of activating
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Behavior
PL
Elizabeth Fucich*
the glutamatergic pyramidal cells in mPFC during extinction for its therapeutic
impact, rats received AAV microinjections into the infralimbic cortex (IL) to
express the Gi-coupled designer receptor activated exclusively by designer drug
(DREADD) hM4Di or control GFP protein, driven by a CamKII promoter. After
four weeks of viral expression, including 2 weeks of CUS or control treatment,
rats received an IP injection of the designer drug clozapine-n-oxide (o.5mg/kg)
followed by extinction training or control treatment 30 min later. They were tested
on the SPDB test 24 hr later. A separate cohort of rats was sacrificed immediately
after fear extinction, the mPFC and lateral septum (LS) were dissected, and
changes in phosphorylation of ribosomal protein S6 were analyzed by Western
blot. All procedures were in accordance with NIH guidelines and approved by
the UTHSCSA Institutional Animal Care and Use Committee.
Results: Extinction training induced Fos protein in the IL of the rat mPFC that
colocalized with CaMKIIα, indicating activation of glutamatergic cells. By
contrast, no Fos protein colocalized with GAD65/67, indicating extinction did not
activate GABAergic cells in the IL. Western blot analysis of LS, a sub-cortical
target of mPFC that mediates active coping behavior on the SPDB test, showed
elevated phosphorylation of ribosomal protein S6 after extinction, suggesting the
induction of protein synthesis. However, inhibiting the mPFC by the Gi DREADD
during extinction did not impact its effect on CUS-compromised coping.
Conclusions: Extinction training reversed the CUS-induced shift from active to
passive coping on the SPDB. Further, extinction activated the mPFC, and increased
pS6 in the LS, an indicator of activity-dependent protein translation and plasticity.
The effect of extinction on coping behavior was not affected by inhibiting the
mPFC, suggesting that this effect may not be due to mPFC modulation of LS, but
that a different brain region activated during extinction influences LS function,
underlying the effect of extinction on coping behavior. Overall, this study further
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PL Behavior
Elizabeth Fucich*
shows that fear extinction is a useful model of CBT, allowing us to investigate
neural mechanisms responsible for its therapeutic effects. Supported by: NIH
training grant T32NS082145, Owen’s Foundation Research Grant, and NIMH
research grant R01MH072672.
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PL
Monday, Poster #118
Emma Knowles*, Kevin Huynh, Joanne Curran, Jack Kent, Harald Goring,
Rene Olvera, Ravi Duggirala, Laura Almasy, John Blangero, Peter Meikle,
David Glahn
Yale University
Background: Evidence is mounting to suggest a key role for inflammation in the
etiology of neuropsychiatric disease including major depressive disorder (MDD).
An inflammation response is characterized by changes in the concentration of
plasma proteins, including lipids. Consequently it is thought that certain lipids
play a crucial role in regulation of the immune response. Thus, we investigate
the differing genetic overlap between 23 lipid classes and a continuous scale of
MDD, using the endophenotype ranking value (ERV), and follow-up on our topranked lipid class using polygenic, linkage and association analyses. Identifying
risk genes for depression, via a focus on plasma-based endophenotypes, might
enhance our understanding of the etiology of MDD, enabling earlier and more
reliable detection as well as, potentially, the development of new and more
effective therapies.
Methods: An ERV, which represents the standardized genetic covariance between
the endophenotype and illness, was calculated for depression (derived using a
factor model of all items from the past depressive episode section of the Mini
International Neuropsychiatric Interview) and 23 lipid classes acquired from 10
μl of plasma. We then followed up on the top-ranked lipid class by, investigating
possible sub-groupings of species within that class, using hierarchical cluster
analysis. We followed up on those sub-groupings, and their genetic overlap with
MDD, using univariate and bivariate linkage and association analysis. All genetic
analysis was conducted in SOLAR in a sample of Mexican-American randomly
selected, extended pedigrees (N=569, 40 families, average size 13.52 people,
range = 2-80, and 29 singletons).
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Emma Knowles*
Results: The highest ranked plasma-based lipid endophenotype for MDD was
the phosphatidylcholines (PCs; ERV = 0.14, h2MDD = 0.20, seMDD = 0.06,
h2PC = 0.38, seMDD = 0.06, rhog = -0.53, p = 0.01). Five clusters emerged from
hierarchical cluster analysis applied to the genetic correlations of all 26 species
of PCs, of these one was significantly associated with MDD after correcting
for multiple tests (h2 = 0.41, se = 0.06, rhog = -0.54, p = 0.011). This cluster
was characterized by those species with an increased number of double bonds.
Significant bivariate linkage was observed for this cluster of PCs and MDD on
chromosome 14 at 112cM (LOD = 3.44). Two genes were found under the peak
C14orf177 and BCL11B, the latter of which is involved in human T-cell function.
Post-hoc bivariate association analysis, correcting for the LD-adjusted number
of SNPs under the peak (α = 1.7x10-04), revealed a suggestively significant
regulatory variant rs1257633 (χ2 = 13.562, p = 1.1x10-03) located in the intergenic
region between the two genes.
Conclusions: PCs have been previously implicated in the etiology of MDD
and anxiety (Demirkan et al, 2013). Moreover, PCs contain arachidonic acid,
an omega-6 fatty acid that is abundant in the brain and which is a precursor to
eicosanoid biosynthesis, where eicosanoids are inflammatory mediators (Lone
et al, 2013). Interestingly, arachidonic acid levels in blood have previously been
associated with symptoms of MDD (Adams et al, 1996; Lotrich et al, 2013). The
results of the present study taken together with previous research suggest that the
genes C14orf177 and BCL11B warrant further investigation as potential candidates
for MDD, particularly when looking at the potential role of inflammation in the
etiology of illness risk.
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Patrick Rothwell*, Scott Hayton, Gordon Sun, Marc Fuccillo, Byungkook Lim,
Robert Malenka
Stanford University
Background: Corticostriatal circuits play a central role in choreographing
movement, including both individual actions and more complex behavioral
routines involving multiple distinct actions performed in sequence. While synaptic
plasticity in the striatum is important for learning to perform many types of actions,
the striatum contains several different cell types that serve as postsynaptic targets
for presynaptic input arising from many sources. The specific source and target
of synapses that undergo plasticity while learning an action sequence have yet to
be identified.
Methods: We used a combination of retrograde and anterograde viral and
optogenetic manipulations in mice to study synapses connecting motor cortex
and dorsolateral striatum. Striatal medium spiny neurons that form the direct
and indirect pathways were targeted using transgenic mice expressing Cre
recombinase driven by Drd1a and Adora2a regulatory sequences. Monosynaptic
projections to the striatum were targeted using retrogradely transported deletionmutant rabies virus. Cells were inhibited by expression of a Kir2.1 potassium
channel, and activated through optogenetic stimulation.
Results: The completion of a simple action sequence was impaired by inhibiting
striatal medium spiny neurons that form the direct pathway. This phenotype
was not due to impairments in movement, motivation, or perseveration. Action
sequence initiation was mediated by cells in the secondary motor cortex that send
monosynaptic projections to the striatum. Slice physiology experiments revealed
that synapses connecting these corticostriatal circuit elements became stronger
after mice learned a sequence of actions. This led to a disparity in striatal output
that favored the direct pathway and was necessary for completion of an action
sequence.
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Patrick Rothwell*
Conclusions: While striatal outputs through the direct and indirect pathway have
opposite behavioral functions, both pathways are active during action initiation.
Our data suggest the completion of an action sequence requires dynamic
modulation of striatal output, leading to a disparity that favors the direct pathway.
This disparity may be driven by the strengthening of excitatory synaptic inputs
from secondary motor cortex onto direct pathway medium spiny neurons - a form
of synaptic plasticity that may encode the chunking or concatenation of sequential
actions.
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Monday, Poster #120
PL
Negar Fani*, Heather Murray, Vasiliki Michopoulos, Kerry Ressler, Bekh
Bradley
Emory University School of Medicine
Background: C-reactive protein (CRP) is a biological marker of systemic
inflammation that has been linked to multiple psychiatric and medical conditions,
many of which involve compromised attention, working memory, and executive
functioning. However, there is a lack of data on whether CRP levels affect
cognition, and whether variants of a gene that affects CRP are associated with
cognition, which was the goal of the present study.
Methods: Genotype data for 41 African-American women aged 22-63 years
were collected for a single nucleotide polymorphism (SNP) of the CRP gene
(rs1130864). The T allele for this SNP has been previously associated with
affective disorder as well as Alzheimer’s disease risk (Ancelin et al., 2015;
Michopoulos et al., 2015; Kok et al., 2011). A battery of neuropsychological
tests (Penn Computerized Neuropsychological Battery), which included tests of
attention, working memory, and executive functioning, was administered. Serum
CRP data was available for 15 of these participants.
Results: Univariate ANOVA results revealed that those with one or two copies
of the T allele had significantly fewer correct responses on the letter-n-back
task on all conditions (F1, 39=6.89, p<.05), including the 2-back condition (F1,
39=4.98, p<.05), compared to individuals without the risk allele. A significant
negative correlation was observed between CRP level and correct responses on
two-back trials (r=-.57; p<.05). Carriers of the risk allele also had more false
positive responses on a visual memory task (delayed recall of visual stimuli; F1,
39=4.31, p<.05).
Conclusions: Conclusions: Certain CRP polymorphisms and resulting high levels
of CRP may increase risk for memory decline, particularly following exposure
to a major stressor. These data suggest that individuals who carry a particular
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PL
Negar Fani*
polymorphism of this gene are likely to experience significantly higher levels of
systemic inflammation and are at greater risk for developing memory problems,
which are prominent features of several medical and psychiatric conditions.
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Schizophrenia
PL
Monday, Poster #207
Toni Mueller*, Stefani Yates, Vahram Haroutunian, James Meador-Woodruff
University of Alabama at Birmingham
Background: The role of posttranslational protein modifications in the
pathophysiology of schizophrenia (SCZ) has become a recent target of
investigation toward understanding the complex mechanisms at play in this
devastating neuropsychiatric illness. One modification, glycosylation, has come
under study due to the role glycan adornment plays in modulating a wide variety
of inter- and intracellular processes. Our lab has reported altered N-glycosylation
of neurotransmitter transporters and receptor subunits and recently identified
abnormal mRNA expression of 36 glycosylation-associated enzymes in SCZ
cortex. A subset of these enzymes, fucosyltransferases (FucTases)and fucosidases,
catalyze the attachment or cleavage of the deoxyhexose fucose on oligosaccharide,
glycoprotein, and glycolipid substrates.
FUT11 is one of several α-1,3-FucTases expressed in brain; however, unlike other
α-1,3-FucTases, FUT11 does not localize to the Golgi and is posited to play a
unique role in cell biology as it does not fucosylate proteins which are common
substrates of other α-1,3-FucTases. The α-1,6-FucTase FUT8 is responsible for
the core fucosylation of the most proximal GlcNAc residue of N-linked glycans.
GDP-fucose protein O-FucTase 1 and 2 (POFUT1 and POFUT2) mediate
O-fucosylation of epidermal growth factor and thrombospondin-like repeat
(TSR) domains, respectively. Substrates of POFUT1 include the NOTCH family
of proteins, important in neuritogenesis and dendritic spine formation in postmitotic neurons. POFUT2 substrates include the ADAMTS family of proteins,
which influence the extracellular matrix (ECM) to permit synaptic remodeling
when they are O-glycosylated with a Glc-β-1,3-Fuc disaccharide. Plasma α-Lfucosidase (FUCA2) is a pH-dependant fucosidase found primarily in the
lysosome and extracellular space playing a role in both glycoprotein degradation
and extracellular molecular interactions with the cell membrane. In order to
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Schizophrenia
Toni Mueller*
elaborate on the potential dysregulation of fucosylation in SCZ we measured
protein expression of these fucosylation enzymes in the superior temporal gyrus
(STG) of SCZ and comparison subjects.
Methods: Samples of gray matter from the full cortical thickness of the left
STG (Brodmann area 22) of 16 SCZ and 14 comparison subjects were obtained
from the Mount Sinai Medical Center brain collection. Prepared samples of
total homogenate were loaded in 4-12% Bis-Tris gels and run using standard
SDS-PAGE and semi-dry transfer methods. Membranes were then probed with
antibodies against FUT8, FUT11, POFUT1, POFUT2, FUCA2, and valosincontaining protein (VCP) as a loading control. The relative abundance of proteins
was determined by measuring the signal intensity of each target normalized to the
signal intensity of VCP.
Results: Protein expression of POFUT2 and FUT8 are altered in schizophrenia.
POFUT2 fucosylates protein TSR domains and demonstrates a 30% increase in
expression relative to comparison subjects in SCZ brain (t(28) = 2.46, p = 0.020).
FUT8 is the only known α-1,6-FucTase in mammals and protein expression
of this enzyme was found to be 35% less in SCZ STG relative to comparison
subjects (t(28) = 2.09, p = 0.046). FUT11, POFUT1, and FUCA2 expression was
not found different between diagnostic groups in STG.
Conclusions: This study demonstrates that protein levels of POFUT2 and FUT8
are abnormal in SCZ, suggesting that altered fucosylation may contribute to
SCZ pathophysiology. Interestingly, these enzymes both play important roles in
neuritogenesis and dendritic spine formation via their modification of substrates
essential for these processes. For example, secretion of some ADAMTS protein
isoforms requires fucosylation by POFUT2 and thus the increased expression of
POFUT2 may facilitate greater transport of these lectican-cleaving molecules into
the extracellular space. Cleavage of lecticans allows the ECM to reform permitting
the cytoskeletal architecture within the cell to push the cell membrane forward
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Schizophrenia
PL
Toni Mueller*
during synapse formation and neuritogenesis. Abnormal ECM remodeling could
contribute to abnormal dendritic spine morphology, which has been reported in
SCZ brain.
The finding of decreased FUT8 expression is particularly noteworthy given recent
evidence from fut8 inhibition in cell culture and fut8 knock-out mice, which
demonstrate functional effects on neurite and synapse formation and a behavioral
phenotype characterized as “schizophrenia-like.” This has been purported to
arise from the dual role of α-1,6-fucosylation-mediated inhibition of the activin
signaling pathway and enhancement of the TGF-β signaling pathway. TGFβ and
activin signaling cascades overlap intracellularly and the contrasting effects of
α-1,6-fucosylation of these substrates has been suggested to mediate neurite
formation in a spatiotemporal manner.
Together, these data suggest that decreased FUT8 expression and increased
POFUT2 expression may affect proper neuritogenesis, dendritic spine
morphology, and synaptic remodeling, all of which are known to be altered in SCZ.
Abnormalities of glycosylation in SCZ have been well-established previously and
these current findings suggest abnormal expression of glycosylation-associated
enzymes may represent an underlying mechanism contributing to alterations of
multiple intra- and intercellular signaling pathways in SCZ. Disruptions to these
essential mediators of cellular function may contribute to the diverse and variable
molecular, cellular, and behavioral abnormalities evident in SCZ pathophysiology.
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PL
Monday, Poster #208
Nina Kraguljac*, Michael Frölich, Steve Tran, David White, Nona Nichols,
Meredith Reid, Adrienne Lahti
University of Alabama at Birmingham
Background: Aberrant hippocampal glutamatergic signaling has been postulated
as a disease mechanism in schizophrenia. Magnetic Resonance Spectroscopy
(MRS) studies found elevated Glx (glutamate+glutamine) in unmedicated
patients with schizophrenia in vivo in different areas of the brain, including
the hippocampus, which may be secondary to N-methyl-d-aspartate receptor
(NMDAR) hypofunction. To test the hypothesis that NMDAR blockage would
result in increased hippocampal Glx, we measured ketamine induced Glx changes
in healthy volunteers.
Methods: We conducted a Magnetic Resonance Spectroscopy (MRS) study to
evaluate changes in hippocampal Glx during a ketamine challenge (0.27mg/kg
over 10 minutes, then 0.25mg/kg/hour for 50 minutes, 0.01ml/s) in a group of
19 healthy volunteers. Psychotomimetic effects were assessed with the Brief
Psychiatric Rating Scale (BPRS) and the Clinician Administered Dissociative
States Scale (CADSS). Imaging was performed on a 3T head-only scanner
(Magnetom Allegra, Siemens Medical Solutions, Erlangen, Germany), equipped
with a circularly polarized transmit/receive head coil. MRS data were collected
from a voxel in the left hippocampus (2.7x 1.5x 1cm). A series of sagittal, coronal,
and axial T1-weighted anatomical scans (gradient-recalled echo sequence, TR/
TE = 250/ 3.48ms, flip angle= 70°, 5mm slice thickness, 1.5mm gap, 512x 512
matrix) were acquired for voxel placement. Following manual shimming, watersuppressed spectra were acquired using the point-resolved spectroscopy sequence
(PRESS; TR/TE= 2000/ 80ms; 1200 Hz spectral bandwidth; 1024 points; number
of averages= 640 (21min 20s). MRS data were analyzed in jMRUI. Spectra
were quantified with respect to creatine in the time domain using the AMARES
algorithm. For statistical analyses, we used a mixed repeated measures design
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PL
Nina Kraguljac*
with neurometabolites as dependent variables, experimental condition as fixed
factor, and voxel grey matter fraction as covariate.
Results: Subjects reported a significant increase in both BPRS and CADSS
scores during the ketamine challenge. We found an increase in Glx with ketamine
compared to saline (saline: 0.62+/- 0.13; ketamine: 0.69 +/-0.08; F= 3.756; p=
0.04), even after excluding statistical outliers (F= 9.408; p< 0.01). We found no
correlations between clinical symptoms and Glx (all p > .05).
Conclusions: Here, we describe an increase of hippocampal Glx during a
ketamine challenge in healthy volunteers that is similar in extent to our previous
report of elevated hippocampal Glx in unmedicated patients with schizophrenia.
This is consistent with a study revealing hippocampal hypermetabolism and
structural deficits in patients transitioning from a prodromal state to syndromal
psychosis, and reporting that ketamine causes increased extracellular glutamate,
hippocampal hypermetabolism, and atrophy in a mouse model, suggesting that
glutamate acts as driver of hippocampal pathology. Because hypermetabolism
and glutamate excess may antedate structural changes, development of drugs
designed to modulate NMDAR function could be promising in the quest of
arresting disease progression in schizophrenia or even in efforts of preventing the
emergence of the full clinical picture.
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Negative Symptoms of Patients With Schizophrenia: A DoublePL Blind, Active Comparator-Controlled Trial
Monday, Poster #206
Marc Debelle, Rene Kahn*, István Laszlovszky, Erzsébet Szalai, György
Németh, Balázs Szatmári, Judit Harsányi, Ágota Barabássy, Suresh Durgam,
Wolfgang Fleischhacker
University Medical Center Utrecht
Background: Cariprazine is an orally active and potent dopamine D3 and D2
receptor partial agonist with preferential binding to D3 receptors. Cariprazine
has demonstrated efficacy for the treatment of schizophrenia in three 6-week,
randomized, double-blind, placebo-controlled, phase II/III clinical trials in
patients with acute psychotic exacerbations and also in chronic stabilized patients
in a relapse prevention clinical trial. Post hoc analysis of the 6-week efficacy
trials on a subset of patients with high levels of negative symptoms demonstrated
significantly greater improvement relative to placebo [Debelle et al., Eur
Neuropsychopharm 2014; 24(Suppl 1): S534; Debelle et al., Eur Psychiatry 2015,
30(Suppl l): 242]. Persistent and predominant negative symptoms of schizophrenia
are burdensome and disabling for schizophrenic patients while no real treatment
options exist at the moment. Therefore, the objective of this clinical trial was to
evaluate the efficacy, safety, and tolerability of cariprazine relative to another
antipsychotic in an adequate and well-conducted clinical trial in patients with
predominant negative symptoms of schizophrenia.
Methods: This study was a multinational, randomized, double-blind, risperidonecontrolled, parallel group clinical trial in adult patients with predominant, negative
symptoms of schizophrenia. To be enrolled in the clinical trial and randomized to
study treatment, patients had to have predominant negative symptoms, defined as
PANSS factor score for negative symptoms (PANSS-FSNS) ≥ 24 and at least 2 of
the 3 core negative symptoms scored at least 4; PANSS factor score for positive
symptoms (PANSS-FSPS) ≤ 19; no clinically relevant depressive symptoms and
no or limited extrapyramidal symptoms; assessed as stabilized with predominant
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Negative Symptoms of Patients With Schizophrenia: A DoubleBlind, Active Comparator-Controlled Trial
PL
Rene Kahn*
negative symptoms for a retrospective 6-month period prior to screening, and for
a prospective 4-week period prior to randomization. Following 2 weeks of crosstitration and discontinuation of previously taken antipsychotic(s), patients were
treated with either cariprazine target dose 4.5 mg/d, or with risperidone target
dose 4 mg/d for 24 weeks. The primary efficacy parameter was the improvement
in negative symptoms, defined as change from baseline (CfB) to endpoint in
PANSS-FSNS. The secondary efficacy parameter was functional improvement,
defined as CfB to endpoint in Personal and Social Performance Scale (PSP) total
score.
Results: 461 patients were randomized 1:1 to double-blind risperidone
(n=231) or cariprazine (n=230) treatment. PANSS-FSNS (27.5 in risperidone,
27.7 in cariprazine treatment groups, respectively), PSP total score (48.1, 48.8
respectively) and PANSS-FSPS (8.6, 8.8 respectively) were similar at baseline
in the two treatment groups. 77.4% of the patients completed the 26-week study
treatment duration, in both groups. CfB at week 26 in the primary parameter,
PANSS-FSNS, was significantly larger in the cariprazine treatment group than in
the risperidone treatment group (LSMD= -1.47; 95% CI: [-2.39, -0.53]; p=0.002;
MMRM, ITT). The mean CfB in the PANSS-FSNS always favored cariprazine
at each follow-up with statistically significant differences from Week 14 onward.
CfB at week 26 in the secondary parameter, PSP total score, showed similarly a
significantly greater improvement with cariprazine when compared to risperidone
(LSMD= 4.63; 95% CI: [2.71, 6.56]; p<0.001; MMRM, ITT). The CfB in the
PSP score always favored cariprazine at each follow-up visit with statistically
significant differences from Week 10 onward. Statistically significant differences
in favor of cariprazine over risperidone at Week 26 were shown in the CfB PSP
self-care area score (P = 0.004), in the PSP socially useful activities area score (P
< 0.001), and in the PSP personal and social relationships area score (P < 0.001).
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Negative Symptoms of Patients With Schizophrenia: A DoublePL Blind, Active Comparator-Controlled Trial
Rene Kahn*
The difference in CfB in the PSP disturbing and aggressive area score between
cariprazine over risperidone at Week 26 was not statistically significant. Patients
tolerated the study treatment well, as reflected by low discontinuation rates due
to adverse events (AEs). The most common AEs (≥10%) during study treatment
were insomnia (10.0%), and headache (10.4%), both in the risperidone treatment
group.
Conclusions: 26-week cariprazine treatment, given as antipsychotic monotherapy,
was significantly more effective on negative symptoms and on functioning than
risperidone in patients with predominant negative symptoms of schizophrenia.
The side effect profiles of cariprazine and risperidone were similar in this study.
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Regency Ballroom 2
Progeny
PL
Mathieu Wimmer*, Lisa Briand, Leonardo Guercio, Adrian Arreola, Heath
Schmidt, Chris Pierce
University of Pennsylvania
Background: Illicit drug use remains a significant public health concern and
constitutes a substantial economic and societal burden worldwide. Cocaine
taking is often associated with global cognitive impairments, including deficits
in attention and declarative memory. Additionally, paternal environmental
perturbations such as chronic stress, a high-fat diet or drugs of abuse can produce
profound effects on the physiology and behavior of offspring via epigenetic
changes in sperm. Our recent studies demonstrated that cocaine exposure in
sires reprogramed the germline epigenome and produced alterations in mood
and addiction-like behaviors in progeny. However, it remains unclear whether
paternal cocaine exposure is associated with cognitive impairments in their
progeny. We hypothesized that paternal cocaine taking might reduce cognitive
function in subsequent generations.
Methods: Behavioral, electrophysiological and molecular biology techniques
were combined to examine the influence of paternal cocaine self-administration
on memory formation and synaptic plasticity in offspring. Male rats selfadministered cocaine daily for 60 days, the duration of spermatogenesis, and
controls received yoked saline infusions. Sires were then bred with drug-naïve
females resulting in cocaine-sired and saline-sired first generation (F1) offspring.
Memory formation was examined in both male and female adult (60 days and
older) drug-naïve offspring. We used a hippocampus-dependent object location
memory task, where animals were exposed to two identical objects. Following a
long (24 hours) or short (30 minutes) delay, animals were returned to the training
arena in which one of the objects was in a novel location. Time spent exploring
each object was recorded during all sessions. Memories are encoded by changes
in synaptic strengths via cellular mechanisms such as long-term potentiation
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PL
Progeny
Mathieu Wimmer*
(LTP). We measured synaptic plasticity in a subset of the animals that were tested
for spatial memory performance no less than two weeks after the behavioral
tests, when rats no longer show any trace of the memory. Hippocampus slices
were collected and theta burst-induced LTP was measured in the Schaffer
collateral pathway. Glutamate signaling through N-methyl-D-aspartate receptors
(NMDARs) in the hippocampus is critically important for memory formation and
synaptic plasticity. Hippocampus tissue was collected from a separate cohort of
naïve adult F1 offspring to measure levels of glutamate, the endogenous NMDAR
co-agonist D-serine, as well as the expression of other molecules critical for
glutamatergic signaling and memory formation.
Results: Male offspring of saline-treated sires spent more time exploring the
displaced object during the 24-hour object location memory test, indicating
intact long-term spatial memory. In contrast, cocaine-sired male progeny showed
impaired long-term memory and explored both objects equally during the 24hour test. Following the acquisition phase of memory formation, short-term labile
memories are converted to longer-lasting traces through a gene- and protein
synthesis-dependent consolidation process. Short-term memory was assessed
30 minutes after training to determine which phase of memory formation was
affected in cocaine-sired progeny. The offspring of cocaine-exposed sires had
impaired short-term memory, suggesting that paternal cocaine taking impairs the
ability of male offspring to form hippocampus-dependent spatial memories. These
learning deficits were sex specific in that object location memory was intact in
all female offspring. Theta bursts-induced LTP in the Schaffer collateral pathway
was impaired in cocaine-sired offspring compared to controls. Interestingly, there
was an overall positive correlation between spatial memory performance and LTP
induction (R2=0.4737, p=0.0192), suggesting that learning and synaptic plasticity
impairments in progeny may be caused by similar underlying mechanisms.
Levels of the endogenous NMDAR co-agonist D-serine, which is critically
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Progeny
PL
Mathieu Wimmer*
involved in memory formation and synaptic plasticity, were diminished in the
hippocampus of cocaine-sired offspring compared to controls. Bath application of
D-serine restored LTP in hippocampal slices from cocaine-sired rats. In addition,
hippocampal micro-injections of D-serine prior to training on the object location
task restored memory in the male offspring of cocaine-exposed sires.
Conclusions: Our results demonstrate that paternal cocaine exposure elicits
learning and synaptic plasticity impairments and that these effects are associated
with reduced D-serine levels in the hippocampus of male progeny.
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Grand Ballroom
From Gene Discovery to Diagnosis and Treatment:
Breast Cancer as a Perhaps Unlikely Model for Mental Illness
PL
Presented by:
Mary-Claire King, Ph.D.
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Grand Ballroom
Mary-Claire King, Ph.D.
University of Washington, Seattle
As precision medicine is becoming the calling across medicine, its application
in clinical neurosciences can be informed by the experience in cancer research
where the approach is achieving initial success. As a pioneer in cancer genomics,
Dr. King is in a unique position to share her tremendous insight on how ground
breaking genomic methodology can be applied to our field. Her talk will give us
a captivating glimpse into where our field is heading.
PL
Mary-Claire King, PhD, is American Cancer Society Professor in the Department
of Medicine and the Department of Genome Sciences at the University of
Washington in Seattle, Washington. She was the first to show that breast cancer is
inherited in some families, as the result of mutations in the gene that she named
BRCA1. In addition to inherited breast and ovarian cancer, her research interests
include the genetic bases of schizophrenia, the genetic causes of Mendelian
disorders in children, and human genetic diversity and evolution. She pioneered
the use of DNA sequencing for human rights investigations, developing the
approach of sequencing mitochondrial DNA preserved in human remains, then
applying this method to the identification of kidnapped children in Argentina and
subsequently to cases of human rights violations on six continents.
Dr. King grew up in Chicago. She received her BA cum laude in Mathematics
from Carleton College in Northfield, Minnesota; her PhD in Genetics from the
University of California at Berkeley; and her postdoctoral training at UC San
Francisco. Her PhD dissertation with Allan Wilson in 1973 was the demonstration
that protein-coding sequences of humans and chimpanzees are 99% identical.
She was professor at UC Berkeley from 1976-1995 and at the University of
Washington in Seattle since 1995.
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Mary-Claire King (continued)
PL
Dr. King has served on the Advisory Committee to the Director of NIH; the
National Commission on Breast Cancer of the President’s Cancer Panel; the
National Academy of Sciences’ Committee on Science, Engineering, and Public
Policy (COSEPUP); and multiple councils and study sections of the NIH and
the National Academy of Sciences. She was consultant to the Commission on
the Disappearance of Persons of the Republic of Argentina and carried out DNA
identifications for the United Nations War Crimes Tribunals. She is past president
of the American Society of Human Genetics and is currently a member of the
Council of the National Academy of Sciences of the USA.
In addition to the National Academy of Sciences, Dr. King has been elected to the
American Academy of Arts and Sciences, the Academy of Medicine (formerly
IOM), the American Philosophical Society, and as a foreign member of the French
Academy of Sciences. She received the Clowes Award in Basic Research from the
American Association for Cancer Research, the Genetics Award from the Gruber
Foundation, the Weizmann Award for Women and Science, the Heineken Prize
for Medicine from the Netherlands Academy of Arts and Sciences, the American
Cancer Society Medal of Honor for Clinical Research, the American Society of
Clinical Oncology Award for Basic Science, and the University of California
Medal. She has received 14 honorary doctoral degrees, from Harvard, Yale,
Columbia, Princeton, Brown, Leuven (Belgium) Tel Aviv (Israel), and Ben Gurion
(Israel) Universities; the State University of New York; Rensselaer Polytechnic
Institute; and Carleton, Smith, Bard, and Dartmouth Colleges. Most recently, in
2014, she received the Lasker Special Achievement Award for Medical Research.
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Panel
Diplomat 1 - 2
The Molecular Pathology and Dynamics
of Spine Loss in Schizophrenia
Chair: Robert Sweet
3:00 PM
Selective Loss of Small Spines in the Auditory Cortex of
Schizophrenia
Matthew MacDonald
PA
3:35 PM
Cellular Functions of Schizophrenia-Enriched Kalirin Mutations
Peter Penzes
4:10 PM
Morphological Brain Abnormalities in Serine Racemase
Knockout Mice: A Genetic Model of NMDA Receptor
Hypofunction
Darrick Balu
4:45 PM
Astrocytic Contributions in Synaptic and Behavioral
Abnormalities of Fragile X Syndrome
Yi Zuo
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Panel
Regency Ballroom 3
A Multi-Modality Imaging Approach for the Identification of
Brain Biomarkers of Clinical Outcomes in Human Addiction
Chair: Nora Volkow
Co-Chair: Roger Meyer
PA 3:00 PM
Using a Multi-Modal Neuroimaging Approach to Track
Longitudinal Changes in Brain Function and Structure, and
Associated Self-Control and Reward Valuation Functions in
Cocaine Addiction
Rita Goldstein
3:35 PM
PET Imaging of the Kappa Opioid Receptor/Dynorphin System
in Cocaine Abuse
Diana Martinez
4:10 PM
Chronic Alcohol-Related Brain Homeostatic and Stress
Alterations and the Development of Biomarkers of Treatment
and Relapse in Alcoholism
Rajita Sinha
4:45 PM
Neurophysiological and HPA Axis Measures of Systemic
Dysregulation as Biomarkers of Treatment Outcome in
Prescription Opiate Dependence
Scott Bunce
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Panel
Regency Ballroom 2
Functional Neurogenomics in Schizophrenia: Recent
Accomplishments and Future Perspectives
Chair: Panos Roussos
Co-Chair: Schahram Akbarian
3:00 PM
Exploring 3-Dimensional Genome Architectures and Function in
Normal and Diseased Human Brain
Schahram Akbarian
PA
3:35 PM
Searching for Potential Mechanisms of Schizophrenia Risk in the
Human Brain
Andrew Jaffe
4:10 PM
Differential Expression and Functional Analysis of MicroRNAs
in Schizophrenia: Focus on miR-132
Claes Wahlestedt
4:45 PM
Transcriptome Alterations in DLPFC and Genetic Liability
Contribute to Risk for Schizophrenia
Panos Roussos
99
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 1
Opportunities and Challenges for
Buprenorphine in Treating Depression
Chair: Irwin Lucki
3:00 PM
PA
Pharmacological Mechanisms Underlying the Antidepressant and
Anxiolytic Effects of Buprenorphine
Irwin Lucki
3:35 PM
Effects of Buprenorphine on Negative Affective Stimuli in
Healthy Adults
Harriet de Wit
4:10 PM
Abuse Potential of Buprenorphine (BPN) in Humans Under
Varying Conditions
Sandra Comer
4:45 PM
Low-Dose Buprenorphine for Late-Life Treatment Resistant
Depression: Assessing Effect and Probing Mechanisms
Jordan Karp
100
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 2
Going With Your Gut: Appetitive Hormones
and the Regulation of Substance Use
Chair: Robert Swift
Co-Chair: Lorenzo Leggio
3:00 PM
A Novel Microendoscopy System for Functional Imaging of
Circuits that Drive Feeding-Reward Behaviors
Yeka Aponte
PA
3:35 PM
New Roles for GLP-1 Receptors in Mediating Reward and Drug
Abuse
Gregg Stanwood
4:10 PM
On the Role of Feeding Peptides in Alcoholism: Recent Clinical
Findings
Carolina Haass-Koffler
4:45 PM
Nicotine and the Endocrine Modulation of Appetitive Responses
Nils Kroemer
101
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Panel
Atlantic Ballroom 3
Extinction: New Directions From Basic Science
to Clinical Interventions
Chair: Tanja Jovanovic
PA
3:00 PM
Persistent Avoidance Depends on Prefrontal-Striatal Interactions
Gregory Quirk
3:35 PM
Fear Network Reactivity and Communication in Response to
Conditioned Threat Across Anxiety Disorders and PTSD
Mohammed Milad
4:10 PM
Translating Fear Extinction Phenotypes: From the Rodent
Chamber to the Clinic
Seth Norrholm
4:45 PM
The Prevention of PTSD with Early Extinction Training
Barbara Rothbaum
102
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Panel
Regency Ballroom 1
As Good as It Gets? New Insights From Genetic and
Circuitry-Based Models of OCD and Tourette Syndrome
Chair: Jeremy Veenstra-VanderWeele
Co-Chair: Susanne Ahmari
3:00 PM
Identifying Neural Activity Changes Underlying OCD-Like
Behaviors Using in Vivo Microscopy
Susanne Ahmari
PA
3:35 PM
Histamine Modulation of Basal Ganglia in a
Pathophysiologically Grounded Model of Tourette Syndrome
Maximiliano Rapanelli
4:10 PM
Characterization of the Putative OCD Risk Gene BTBD3 Using
Mouse Models
Stephanie Dulawa
4:45 PM
Investigation of EAAT3 Reduction as a Therapeutic Target for
Obsessive Compulsive Disorder
Jeremy Veenstra-VanderWeele
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Study Group
Great Hall 5-6
Reproducibility and Robustness of Experimental Data in the
Neurosciences - Opportunities for Improvements
Chair: Raquel Gur
Co-Chair: Thomas Steckler
SG
Participants:
George Koob
Patricio O’Donnell
Anton Bespalov
Robert Freedman
Stephan Heckers
Mark Geyer
Elena Koustova
Malcolm Macleod
Magali Haas
104
11/10/15 9:58 AM
Notes
105
11/10/15 9:58 AM
Notes
106
11/10/15 9:58 AM
8:30 AM – 9:45 AM
Mini-Panel
Regency Ballroom 1
Sharing is Caring: An Overview of the Data Sharing Landscape
Chair: Frank Yocca
Co-Chair: William Potter
8:30 AM
Data Sharing at NIMH
Bruce Cuthbert
8:55 AM
Perspectives on Responsible Clinical Trial Data Sharing
Timothy Coetzee
9:20 AM
Current Practices for Sharing Data: The Landscape in the Private
Sector
Lisa Gold
MP
107
11/10/15 9:58 AM
9:45 AM – 11:00 AM
Mini-Panel
Regency Ballroom 1
Brain-Wide ‘Glymphatic’ Pathway: Visualization and Function
Chair: Helene Benveniste
9:45 AM
Evidence for the Impairment of Glymphatic Pathway Function in
the Aging Brain
Jeffrey Iliff
10:10 AM
Metabolic Aspects of Cerebral Capillary Water Efflux
William Rooney
MP 10:35 AM
Brain-Wide Glymphatic Transport in the Unconscious State:
Influence of Body Position
Helene Benveniste
108
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Regency Ballroom 3
Behavioral Implications of Adult Neurogenesis and
Its Potential as Treatment Target
Chair: Maura Boldrini
8:30 AM
Tuning Lineage Homeostasis to Rejuvenate Memory Circuits and
Constrain Fear Generalization in Adulthood and Aging
Amar Sahay
9:05 AM
Stress, Unpredictability, and the Role of Adult Neurogenesis in
Response to Threat
Heather Cameron
PA
9:40 AM
Modes of Division and Differentiation of Adult Neural Stem
Cells May Define Long Term Consequences of Therapies
Grigori Enikolopov
10:15 AM
Molecular Regulation of Hippocampal Neurogenesis in
Neuropsychiatric Disease and Treatment
Maura Boldrini
109
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Regency Ballroom 2
The Role of Epigenetic Mechanisms in the
Transition into Alcohol Addiction
Chair: Markus Heilig
Co-Chair: Claes Wahlestedt
8:30 AM
The Role of Epigenetic Mechanisms in the Medial Prefrontal
Cortex in the Transition to Alcohol Dependence
Markus Heilig
PA
9:05 AM
A Novel Role for the Histone Demethylase KDM6B in Alcohol
Dependence
Andrea Johnstone
9:40 AM
Breakdown in the Corticostriatal BDNF Pathway Drives the
Transition From Social to Compulsive Drinking for Alcohol
Dorit Ron
10:15 AM
Transcriptome Sequencing Reveals Novel Splice Variants in
Human Alcoholic Brain
Dayne Mayfield
110
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Atlantic Ballroom 1
From Animals to Humans: The Role of
Neuroinflammation in Psychosis and Psychosis Risk
Chair: Romina Mizrahi
Co-Chair: Oliver Howes
8:30 AM
Neuroinflammation and Oxidative Stress Precede the Onset
of Schizophrenia-Relevant Behavioral Dysfunctions in Mouse
Models of Prenatal Infection
Urs Meyer
PA
9:05 AM
Study of Altered Markers of Oxidative Stress in Patients With
Early Stage Schizophrenia
Jennifer Coughlin
9:40 AM
PET Imaging of Microglia in Drug Naive Patients at High Risk
of Psychosis and the Effects of Antipsychotics on Microglia
Oliver Howes
10:15 AM
Imaging Neuroinflammation in Clinical High Risk and First
Episode Antipsychotic Free Psychosis: An in-Vivo PET Study
With [(18)F]-FEPPA
Romina Mizrahi
111
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Atlantic Ballroom 2
Genetic Approaches to Delay Discounting:
Human and Non-Human Animal Approaches
Chair: Abraham Palmer
Co-Chair: James MacKillop
8:30 AM
Genetic Basis of Impulsive Behavior in Humans Project: Initial
Delay Discounting Findings
James MacKillop
PA
9:05 AM
Genetics of Delay Discounting in Humans: Heritability and
Preliminary Evidence for Genetic Association
Andrey Anokhin
9:40 AM
Strategies and Results When Using Mouse Models to Identify
Commonalities Between a Delay Discounting Endophenotype
and Endophenotypes Associated With Alcohol Use Disorder
Suzanne Mitchell
10:15 AM
Identification of Individual Differences in Delay Discounting by
Heterogeneous Stock Rats
Jerry Richards
112
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Atlantic Ballroom 3
The Road to Recovery:
Delineating the Neural Circuits of Compulsive Drug Use
Chair: Susan Ferguson
8:30 AM
The ‘Ins’ and ‘Outs’ of the Striatum: Mapping Addiction Circuits
Susan Ferguson
9:05 AM
Corticostriatal Mechanisms of Compulsive Cocaine Seeking in
Rats
Barry Everitt
PA
9:40 AM
Dynamic Changes in Phasic Dopamine Release to DrugAssociated Cues Following Chronic Use and Withdrawal
Paul Phillips
10:15 AM
Functional Network Connectivity Between Rostral ACC and
Insula Predicts Response to Varenicline for Tobacco Dependence
(TD)
Claire Wilcox
113
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Study Group
Diplomat 1 - 2
The Future of Sex Difference Research in
Chair: Debra Bangasser
Co-Chair: Rebecca Shansky
SG
Participants:
Mohammed Milad
Tracy Bale
David Rubinow
Margaret McCarthy
Janine Clayton
Jill Becker
114
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Study Group
Great Hall 5-6
rt-fMRI Neurofeedback: Are We There Yet?
Chair: Steven Grant
Co-Chair: Vani Pariyadath
Participants:
Pearl Chiu
Anna Rose Childress
Hans Breiter
Anne Evins
Mark George
Sean Mackey
Jon-Kar Zubieta
SG
115
11/10/15 9:58 AM
11:00 AM - 1:00 PM
Women’s Luncheon
Grand Ballroom
ACNP Women’s Luncheon
Negotiations
Presented by the ACNP Women’s Task Force
Co-Chairs: Linda S. Brady and Suzanne Haber
Featured Speaker: Nora Volkow
The theme of this luncheon session will be negotiations in the workplace,
including topics such as negotiating resources, space, teaching, publishing, and
authorship. This theme was selected as the topic of highest interest based on the
results of the 2015 Women’s Luncheon Topic Survey.
PL The venue will be small tables of eight, including two table leaders to facilitate
discussion (junior/senior table leaders, basic and clinical researchers). Box lunches
will be provided instead of a formal luncheon to facilitate table discussions and
interactions.
The featured speaker, Nora Volkow, will provide her perspective on experiences,
mentors, role models and diversity, throughout her career and the balance of
adapting to versus changing the scientific environment in which one works.
11:00 AM
Table introductions, box lunches, and informal discussion
11:30 AM
“Perspectives of an Hispanic female scientist: Challenges and
Opportunities” presented by Nora Volkow
12:15 PM
Table leaders will facilitate discussions of questions and issues
relevant to negotiations in the workplace
116
11/10/15 9:58 AM
1:30 PM – 3:00 PM
Special Session
Regency Ballroom 1
Career Development Session
“The Nuts and Bolts of ACNP Membership”
Membership Advisory Task Force Chair: Christina Barr
Membership Advisory Task Force Co-Chair: Vaishali Bakshi
Moderators: Daniel Mueller and Kay Tye
Participants:
Karen Szumlinski
Gregory Light
Victoria Arango
David Goldman
This session will focus on the FAQs of applying for Associate and Regular
Memberships in the College. The panel will identify qualities of successful
applications and provide information on membership trends in the last several
years. The Membership Advisory Taskforce has collected and analyzed data
from last years’ applications which are regularly presented as poster at the ACNP
meetings. Frequently asked questions by attendees will be discussed, such as how
to judge the best moment to apply and how different merits might be weighed
against each other (e.g., publications vs. grant track records).
The session will also discuss how to attract and encourage junior scientists and
mechanisms through which interested non-members ca attend meetings. These
include how to ‘break the ice’ with College members – in other words, how can
someone find ways to interact with more senior members of the College will be
provided. Also to be discussed is what the College does to promote applications
from females and minorities. Given that travel awards serve to facilitate entrance
to the ACNP, another emphasis will be to discuss strategies for successful
applications for Travel Awards. Related to these topics, the group will discuss
how an applicant for membership/travel award can show commitment to the
College (important criterion for membership) in addition to attending the meeting
(since this requires an invitation and therefore can be a ‘catch-22’). Last, but not least, the panel will discuss how membership in the College dovetails
with overall career progression – how can ACNP membership be beneficial for
one’s own career plans.
PL
117
11/10/15 9:58 AM
3:00 PM – 4:15 PM
Mini-Panel
Regency Ballroom 1
Social (Cognitive) Functioning in Schizophrenia:
Course, Mechanisms, and Treatment
Chair: Abraham Reichenberg
Co-Chair: Michael Green
3:00 PM
The 20-Year Longitudinal Trajectories of Social Functioning in
Psychotic Disorders
Eva Velthorst
3:25 PM
Levels of Empathy in Schizophrenia
Michael Green
MP
3:50 PM
Oxytocin for Schizophrenia: A Randomized Controlled Trial
Mark Weiser
118
11/10/15 9:58 AM
4:15 PM – 5:30 PM
Mini-Panel
Regency Ballroom 1
Neuropsychiatric Disorders in Isolated Populations
Chair: Francis McMahon
4:15 PM
Clustering of Mendelian Disease Loci and Bipolar Disorder Risk
Alleles in a Large Multigenerational Old Order Amish Pedigree
Maja Bucan
4:40 PM
Heritable White Matter Diffusion Endophenotypes and Traits in
Population Isolate
Elliot Hong
5:05 PM
Genome Sequencing of Anabaptist Patients With Bipolar
Disorder Reveals Enrichment of Rare, Functional Variants
Within Genes Involved in GTPase Signaling
Francis McMahon
MP
119
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Diplomat 1 - 2
Signals From the 4th Dimension: How the Extracellular Matrix
Regulates Synaptic Plasticity and Neuropsychiatric Disease
Chair: Peter Kalivas
3:00 PM
Mechanisms Through Which Extracellular Proteolysis Shapes
Neuronal Structure and Function
George Huntley
3:35 PM
Role of Perineuronal Nets in Cocaine-Induced Plasticity
Barbara Sorg
4:10 PM
PA
Matrix Metalloproteinases and Cell Surface-Associated
Substrates
Katherine Conant
4:45 PM
Nitric Oxide Signaling in the Accumbens Core Drives Relapse to
Cocaine Seeking
Alexander Smith
120
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Regency Ballroom 3
Neuroimaging, Addiction and Big Data:
Opportunities and Challenges
Chair: Martin Paulus
3:00 PM
Prediction of Substance Misuse Initiation (Alcohol, Nicotine and
Cannabis): Insights From the Imagen Project
Robert Whelan
3:35 PM
A Selective Drug and Alcohol Prevention Programme That
Targets Neurocognitive Correlates of Sensation Seeking: Focus
on Reward Sensitivity
Patricia Conrod
4:10 PM
ENIGMA Addiction Working Group: Initial Findings
Scott Mackey
PA
4:45 PM
Bayesian Neural Adjustment of Inhibitory Control Predicts
Emergence of Problem Stimulant Use
Martin Paulus
121
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Regency Ballroom 2
Schizophrenia as a “Dysplasticity” Disorder
Chair: Sophia Vinogradov
Co-Chair: Matcheri Keshavan
3:00 PM
Experience-Dependent Dysregulation of Plasticity in the Aging
and Younger “Noisy” Brain
Etienne de Villers-Sidani
3:35 PM
Dysplasticity, Metaplasticity and Schizophrenia: Implications for
Risk, Illness Progression, and Novel Preventive Interventions
Matcheri Keshavan
4:10 PM
PA
Developmental Trajectory of Brain Bioenergetics and
Oxidative Stress Measures in Schizophrenia: Implications for
“Dysplasticity”
Dost Ongur
4:45 PM
Abnormal Cortical Activation Patterns in People With
Schizophrenia may Represent Compensatory Plasticity
Sophia Vinogradov
122
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 1
Inflammation-Induced Modulation of Motivation:
Impact on Neurotransmitters and Neurocircuits
Chair: Andrew Miller
3:00 PM
Preclinical Characterization of Inflammation-Induced
Motivational Deficits
Elisabeth Vichaya
3:35 PM
A Neuro-Computational Account of How Inflammation
Diminishes Sensitivity to Reward and Simultaneously Promotes
Avoidance Behavior
Neil Harrison
4:10 PM
Inflammatory Responses to Stress are Associated With Altered
Prediction Error Signaling During Reinforcement Learning
Michael Treadway
PA
4:45 PM
Inflammation-Related Decreases in Dopamine and Effects on
Corticostriatal Reward Circuitry: Evidence From Humans and
Non-Human Primates
Jennifer Felger
123
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 2
Molecular Mechanisms Underlying Psychopathology
and Treatments in OCD
Chair: Helen Simpson
Co-Chair: Carolyn Rodriguez
3:00 PM
Role of Slitrk5 and PTPRD in BDNF-Dependent Synapse
Remodeling
Francis Lee
3:35 PM
Rare Functional Mutations in SLITRK5 are Associated With
OCD
Carol Mathews
PA
4:10 PM
From Good Habit to Bad: Corticostriatal Synaptic and Circuit
Mechanisms in Habit and Compulsion
Nicole Calakos
4:45 PM
Pilot Trial of a Brief Course of Exposure-Based CBT in
Extending IV Ketamine’s Effects in OCD
Carolyn Rodriguez
124
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 3
Research Paradigms and Non-Pharmacological Interventions
Aimed to Prevent the Onset and Progression of Bipolar Disorder
in Children
Chair: Mary Phillips
Co-Chair: Manpreet Singh
3:00 PM
White Matter Structure of Major White Matter Tracts in Youth
Offspring of Bipolar and Non-Bipolar Parents
Amelia Versace
3:35 PM
Neurofunctional Characteristics of Risk and Resilience in Youth
Offspring of Bipolar Parents
Manpreet Singh
4:10 PM
Neural Correlates of Symptom Improvement Following Family
Focused Therapy for Youth at High-Risk for Bipolar Disorder
Kiki Chang
PA
4:45 PM
Neurofunctional Changes Associated With Mindfulness-Based
Cognitive Therapy in Youth at Risk for Bipolar Disorder
Melissa DelBello
125
11/10/15 9:58 AM
3:00 PM – 5:30 PM
Study Group
Great Hall 5-6
Training Aspects of International Research Collaborations:
Experiences From Multinational Initiatives in Biological
Psychiatry Between the USA, Europe, Asia, and Africa
Chair: Thomas Schulze
Co-Chair: Raquel Gur
SG
Participants:
Akira Sawa
Frank Schneider
George Koob
Bruce Cuthbert
Tobias Halene
Chao Chen
Chunyu Liu
Susan Weiss
Triptish Bhatia
Ibtihal Ibrahim
Vishwajit Nimgaonkar
Ruben Gur
Isabella Schneider
Yoichiro Takayanagi
126
11/10/15 9:58 AM
Notes
127
11/10/15 9:58 AM
Notes
128
11/10/15 9:58 AM
8:30 AM – 9:45 AM
Mini-Panel
Regency Ballroom 1
Prenatal Maternal Environment, Immune Mechanisms,
and Neurodevelopment Relevant to Psychiatric
Disorders and Preventive Mechanisms
Chair: James Leckman
Co-Chair: Hanna Stevens
8:30 AM
Maternal High Fat Diet Alters Long-Term Metabolic,
Monoamine, Neuroimmune, and Behavioral Outcomes in Mouse
Offspring: A Role for Placental Inflammation?
Staci Bilbo
8:55 AM
Interaction Between Serotonin Transporter Genotype and
Prenatal Stress on Neurodevelopment With Implications for
Autism Spectrum Disorder
David Beversdorf
9:20 AM
Inflammatory Mediators of Prenatal Stress Effects on
Neurodevelopment
Hanna Stevens
MP
129
11/10/15 9:58 AM
9:45 AM – 11:00 AM
Mini-Panel
Regency Ballroom 1
Harnessing Sex-Differences as Biological Clues in
Neurodevelopmental Psychiatry
Chair: Armin Raznahan
9:45 AM
The Female Protective Effect in Autism Spectrum Disorder
Stephan Sanders
10:10 AM
Sex Differences in the Infant Brain: Mechanistic Considerations
and Relevance to Neurodevelopmental Disorders
Rebecca Knickmeyer
10:35 AM
Studying the Where and How of Sexually Dimorphic Brain
Development Through Cross-Species Neuroimaging and
Genomics
Armin Raznahan
MP
130
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Diplomat 1 - 2
Complimentary and Integrative Treatment
for Mood and Anxiety Disorders
Chair: Mark Rapaport
Co-Chair: Emmeline Edwards
8:30 AM
Molecular Loci for Antidepressant Effects of n-3 Polyunsaturated
Fatty Acids
Mark Rasenick
9:05 AM
Depression, Inflammation, and Omega-3 Fatty Acids
David Mischoulon
9:40 AM
Massage Therapy for GAD: Lessons Learned About Outcomes,
Hormones, and Immune Function
Mark Rapaport
10:15 AM
Complementary and Integrative Health Approaches for Mental
Health Conditions
Emmeline Edwards
PA
131
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Regency Ballroom 3
Synaptic Addiction: New Insights Into the Cellular Mechanisms
of Drug Action and Substance Use Disorders
Chair: Sachin Patel
Co-Chair: Stephanie Borgland
8:30 AM
From Optogenetics to rTMS: A Clinical Trials on Cocaine
Craving
Antonello Bonci
9:05 AM
Strengthening Accumbal Indirect Pathway Promotes Resilience
to Compulsive Cocaine Use
Veronica Alvarez
9:40 AM
Neuroplasticity in Fronto-Cortical Circuits Associated With
Compulsive Eating
Stephanie Borgland
10:15 AM
PA
Nucleus Accumbens Parvalbumin Expressing Interneurons
Regulate Synaptic and Behavioral Plasticity
Brad Grueter
132
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Regency Ballroom 2
Normalizing Cognitive Impairments in Schizophrenia:
New Leads From Novel Glutamatergic Manipulations
Chair: Joseph Coyle
Co-Chair: Robert Schwarcz
8:30 AM
Cognitive Enhancement Through Inhibition of Kynurenic Acid
Synthesis
Robert Schwarcz
9:05 AM
Calcium-Permeable AMPA Receptor and Asc-1 Transporter
Regulate the Cortical Extracellular D-Serine Concentration:
Potential Targets for Development of Novel Pharmacotherapy for
NMDA Receptor Dysfunction in Schizophrenia
Toru Nishikawa
9:40 AM
Endogenous D-Serine Maintains the Level of NMDA Receptor
Activation Required for LTP Induction at Hippocampal Synapses
Vadim Bolshakov
10:15 AM
Oxidative Stress in Interaction With NMDA Receptor
Hypofunction as a Core Mechanism in Schizophrenia
Pathophysiology: Spatial-Temporal Development and Potential
Protection with Antioxidants
Kim Do
PA
133
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Atlantic Ballroom 1
The Research Domain Criteria (RDoC) Initiative:
New Data Across Psychiatric Conditions and Age Groups
Chair: Ellen Leibenluft
Co-Chair: Bruce Cuthbert
8:30 AM
A Multi-Modal Assessment of Positive Valence Systems Across
Unipolar and Bipolar Depression
Diego Pizzagalli
9:05 AM
The Neuroimmunology of Anhedonia and Related Positive
Valence System Deficits in Adolescents
Vilma Gabbay
9:40 AM
Do the Neural Mechanisms Mediating Irritability Differ Across
Diagnoses?
Ellen Leibenluft
10:15 AM
PA
A Common Functional Topography Across the Major Psychiatric
Disorders
Sophia Frangou
134
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Atlantic Ballroom 2
Caffeine Interactions With Dopamine in Adolescence:
An Unappreciated Risk for Obesity and Addiction?
Chair: Cynthia Kuhn
Co-Chair: Ryan Bachtell
8:30 AM
Addiction Vulnerability Characteristics Following Adolescent
Caffeine Consumption
Ryan Bachtell
9:05 AM
Changing Classical Pharmacology by Exploring the Allosteric
Mechanisms of Caffeine Within the Adenosine A2A-Dopamine
D2 Receptor Heterotetramer
Sergi Ferre
9:40 AM
Adenosine Regulation of Dopamine Release and Behavior in
Adolescent Rats
Cynthia Kuhn
10:15 AM
Motivational Effects of Caffeine in Adult and Adolescent Rats
Matthew Palmatier
PA
135
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Panel
Atlantic Ballroom 3
Mining a Genomic Hotspot for Psychosis:
Mechanistic Insights From 22q11.2 Microdeletions
Chair: Carrie Bearden
Co-Chair: Joshua Gordon
8:30 AM
From Genes to Cognition in a Mouse Model of the 22q11.2
Microdeletion
Joshua Gordon
9:05 AM
Thalamic MicroRNA Controls Antipsychotic Sensitivity of
Thalamocortical Projections in the Auditory Cortex of Mouse
Models of 22q11 Deletion Syndrome
Stanislav Zakharenko
9:40 AM
Cortico-Thalamic Circuits and Psychosis Risk in 22q11.2
Deletion Carriers
Carrie Bearden
PA 10:15 AM
Using Patient-Derived Neurons to Gain Novel Insights Into the
Neuronal Basis of 22q11 Deletion Syndrome
Sergiu Pasca
136
11/10/15 9:58 AM
8:30 AM - 11:00 AM
Study Group
Great Hall 5-6
The Sunshine Act: Implications for Neuropsychiatric
Researchers and Neuropsychiatric Research - An ACNP Liaison
Committee-Sponsored Study Group
Chair: Daniel Javitt
Participants:
Paul Appelbaum
William Carpenter
Laura Roberts
Charles Beasley
Daniel Carlat
Maria Oquendo
SG
137
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Diplomat 1 - 2
Sex Hormones, the Medial Prefrontal Cortex and Their Role on
Eating Disorder Behavior in Basic Science and Human Brain
Imaging Studies
Chair: Guido Frank
3:00 PM
An Individual Differences Animal Model of Binge Eating
Reveals Sex Differences in Binge Eating-Proneness and
Enhanced Activation of the Neural Reward Circuit by Palatable
Food in Binge Eating-Prone Rats
Cheryl Sisk
3:35 PM
Disruption of ESRRA-HDAC4 Activity in Prefrontal Cortex
Induces Eating Disorder-Related Behaviors in Mice
Michael Lutter
4:10 PM
Medial Prefrontal Cortex is Integral to Altered Social and Self
Perception in Anorexia Nervosa
Carrie McAdams
4:45 PM
Brain Structure and Function Implicate the Medial Prefrontal
Cortex in Anorexia Nervosa Pathophysiology
Guido Frank
PA
138
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Regency Ballroom 3
A Fresh Perspective on Neuregulin in Schizophrenia
Chair: Cynthia Shannon Weickert
Co-Chair: Tim Karl
3:00 PM
Schizophrenia-Relevant‚ Endophenotypes in Transgenic Mouse
Models of NRG1/ErbB4 Hyperstimulation
Markus Schwab
3:35 PM
Evaluating the Validity of a Novel Transgenic Mouse Model for
Neuregulin 1 Type III for Schizophrenia
Tim Karl
4:10 PM
Structural Brain Morphometry and NRG1 Gene Variants in
First-Episode Nonaffective Psychosis: Cross-Sectional and
Longitudinal Analyses
Benedicto Crespo-Facorro
4:45 PM
Neurobiological Consequences of Neuregulin-1 Loci Associated
With Psychosis Onset
Chad Bousman
PA
139
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Regency Ballroom 2
Real-Life Proxies of Social Context in Affective Problems Across
the Lifespan: Evidence from Human and Rodent Studies
Chair: Erika Forbes
Co-Chair: David Hsu
3:00 PM
Reward and Social Circuitry: A Link Between Adolescents’
Depression and Real-Life Social Experiences?
Erika Forbes
3:35 PM
Long-Term Neurobiological Consequences of Physical Versus
Emotional Stress During Adolescence in Male Mice
Carlos Bolanos-Guzman
4:10PM
Endogenous Opioid Release and BOLD Activation During
Romantic Rejection and Acceptance: Implications for Impaired
Social Functioning in Major Depressive Disorder
David Hsu
4:45 PM
How Does the Brain Understand the Death of a Loved One?
Neural Correlates of Complicated Grief in Older Adults
Mary-Frances O’Connor
PA
140
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 1
Advances From Three Hallmark Genetic Consortia on
Endophenotypes in Schizophrenia to Four Collaborations
Operating at the Exciting Frontiers of Genomic Science
Chair: David Braff
3:00 PM
De Novo Mutations in Schizophrenia Map to Prefrontal Cortical
Network
Jon McClellan
3:35 PM
Associations of Gene Expression With Schizophrenia and
Related Neurocognitive Endophenotypes
Laura Almasy
4:10 PM
Linking Clinical Outcome and Genotype to Schizophrenia
Predisposition Using Stem Cells
Kristen Brennand
4:45 PM
Epigenetics of Schizophrenia
Andrew Feinberg
PA
141
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 2
The Role of Neuroinflammation in Depression:
PET Imaging and Clinical Implications
Chair: Robert Innis
3:00 PM
Positron Emission Tomographic Imaging of Translocator Protein
(TSPO) as a Biomarker of Neuroinflammation in Alzheimer’s
Disease
Robert Innis
3:35 PM
New Evidence That Microglial Activation, an Important
Component of Neuroinflammation, Is found Throughout Grey
Matter Regions in the Brain During Major Depressive Episodes
Jeffrey Meyer
4:10 PM
Using PET Imaging of Translocator Protein (TSPO) to
Investigate the Link Between Inflammation and Depression
Erica Richards
4:45 PM
Efficacy of the Anti-Inflammatory Agents Minocycline and
Aspirin in Bipolar Depression
Wayne Drevets
PA
142
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Atlantic Ballroom 3
Fear Generalization: Neurobiological and Behavioral
Mechanisms Across the Pre-Clinical and Clinical Spectrum
Chair: Kerry Ressler
Co-Chair: Rajendra Morey
3:00 PM
Fear Learning Circuitry is Biased Toward Generalization of Fear
Associations in Posttraumatic Stress Disorder
Rajendra Morey
3:35 PM
Erring on the Side of Caution: One Cell at a Time
Sumantra Chattarji
4:10 PM
Aversive Learning and Generalization Predict Sub-Clinical
Anxiety Symptoms Six Months Later
Bram Vervliet
4:45 PM
The Effect of Generalized Fear Learning on Episodic Memory
Joseph Dunsmoor
PA
143
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Panel
Regency Ballroom 1
Probing the Perinatal Expression of Risk for Mental Disorder:
Basic Molecular, Neurobiological, Neuroimaging and Clinical
Intervention Studies in Pregnancy and Fetal Development
Chair: Robert Freedman
3:00 PM
Neurexin 1 (NRXN1) Gene Expression Across the Normal
Human Lifespan: Implications for Normal and Abnormal
Neurodevelopment
Amanda Law
3:35 PM
Genetic Neuropathology in Human Brain Development and
Schizophrenia
Joel Kleinman
4:10 PM
Altered Amygdala Functional Connectivity in Neonates at Risk
for Schizophrenia or Bipolar Disorder
John Gilmore
4:45 PM
PA
Human Perinatal Choline Supplementation Decreases Preschool
Parent-Reported Attentional and Social Withdrawal Symptoms
via an alpha7 Nicotinic Cholingergic Receptor Mediated Effect
on Infant Developmental of Sensory Gating
Randal Ross
144
11/10/15 9:58 AM
3:00 PM - 5:30 PM
Study Group
Great Hall 5-6
Neurocircuit-Based Interventions in Addictions:
When and How?
Chair: David Goldman
Co-Chair: Primavera Spagnolo
Participants:
Antonello Bonci
Gary Aston-Jones
Trevor Robbins
Meaghan Creed
Damiaan Denys
Alan Green
Paul Holtzheimer
Osama Abulseoud
Ali Rezai
Moderator: Helen Mayberg
SG
145
11/10/15 9:58 AM
Notes
146
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Diplomat 1 - 2
The Role of Impulsivity vs. Impulse Control on the
Developmental Trajectories of SUD - New Insights From
Neuroimaging Research
Chair: Edythe London
Co-Chair: Iliyan Ivanov
8:00 AM
A Longitudinal fMRI Study of Reward and Inhibitory Control in
Youth at Risk for Substance Use Disorder
Mary Heitzeg
8:35 AM
Neural Activation to Response Inhibition Predicts Subsequent
Substance Use Initiation and Escalation in Adolescence
Susan Tapert
9:10 AM
A Longitudinal Investigation of Reward and Control Brain
Systems as Predictors of Adolescent Drug Use
Hugh Garavan
9:45 AM
Impulsivity and Reward Processing in Drug Naïve Youth at Risk
for Substance Use Disorders
Iliyan Ivanov
PA
147
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Regency Ballroom 3
Ontogeny of Autism: Identification of Very Early
Signs of Autism Spectrum Disorder in Humans and Mice
Chair: Noboru Hiroi
8:00 AM
Onset of ASD and Behavioral Signs in the First Year of Life
Sally Ozonoff
8:35 AM
Vocal Development in Infants and Children With ASD
D. Kimbrough Oller
9:10 AM
Modeling Social Communication Deficits in Mouse Models of
Autism
Maria Luisa Scattoni
9:45 AM
Structure and Function of Neonatal Social Communication in a
Genetic Mouse Model of Autism
Noboru Hiroi
PA
148
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Regency Ballroom 2
Using Neural Connectivity Biomarkers in Major Depressive
Disorder (MDD) to Identify Subtypes and Predict Treatment
Response
Chair: Diego Pizzagalli
Co-Chair: Scott Langenecker
8:00 AM
Abnormal Resting State Functional Connectivity as a Biomarker
for Major Depressive Disorder (MDD) and Clinical Subtypes
Roselinde Kaiser
8:35 AM
Cognitive Control Performance and Salience Network to
Cognitive Control Hyperconnectivity Predict Depression Relapse
in Early Adulthood
Scott Langenecker
9:10 AM
Functional Connectivity Predictors of Response to Behavioral
Activation Therapy for Depression
Gabriel Dichter
9:45 AM
Differences in Resting State Functional Connectivity Between
Patients With Treatment-Resistant Versus Treatment-Responsive
Depression
Paul Holtzheimer
PA
149
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Atlantic Ballroom 1
Combining Imaging Modalities in Understanding
and Treating Stress-Related Disorders
Chair: Amit Etkin
Co-Chair: Christian Schmahl
8:00 AM
Disrupted Neural Synchrony During Social Interaction in
Borderline Personality Disorder
Edda Bilek
8:35 AM
Amygdala Neurofeedback Modulates Amygdala-VMPFC
Connectivity in Healthy Participants and Borderline Patients
Christian Schmahl
9:10 AM
Real-Time fMRI Emotion Regulation Training in PTSD:
Altered Amygdala Activity and Connectivity as a Function of
Depersonalization
Ruth Lanius
9:45 AM
Identification of a Causal Pathway for Amygdala Control in
Humans and Abnormalities in PTSD
Amit Etkin
PA
150
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Atlantic Ballroom 2
Genomes and Cells:
New Models for Target Discovery and Validation
Chair: Daniel Weinberger
8:00 AM
Probing Neural Phenotype in Macrocephalic Autism
Maria Marchetto
8:35 AM
Using IPSC Models to Identify Cellular Phenotypes Associated
with Autism and Schizophrenia
Ricardo Dolmetsch
9:10 AM
Ectopic Expression of Peripheral Ion Channel Genes in the
Central Nervous System Underlies an Autism Spectrum Disorder
Brady Maher
9:45 AM
Modeling Major Mental Disorders Using Patient-Derived iPSC
and Humanized Mouse Models
Hongjun Song
PA
151
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Atlantic Ballroom 3
Studies of Stress Identify Novel Signal Transduction
and Epigenetic Antidepressant Targets
Chair: Ronald Duman
Co-Chair: Venetia Zachariou
8:00 AM
REDD1/mTORC1/S6K1 Signaling and Synapse Formation in the
Pathophysiology and Treatment of Depression
Ronald Duman
8:35 AM
RGS4 Plays a Key Role in the Efficacy of Classical and FastActing Antidepressants
Venetia Zachariou
9:10 AM
Cell Type-Specific Epigenetic Reprogramming of the Fosb Gene
Controls Depression-Related Behaviors
Elizabeth Heller
9:45 AM
Maternal Stress Epigenetic Programming Through Maternal and
Fetal Exosomes
Tracy Bale
PA
152
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Panel
Regency Ballroom 1
Orphan GPCRs and Psychiatric Disorders
Chair: Mickey Matsumoto
Co-Chair: Olivier Civelli
8:00 AM
Orphan GPCRs in Psychiatry
Olivier Civelli
8:35 AM
An Orphan GPCR Highly Enriched in the Medial Habenula and
Lateral Septum Detects L-Tryptophan and L-Phenylalanine and
May Represent a Novel Sensor That Modulates Behavior
Timothy Lovenberg
9:10 AM
GPR88: An Orphan GPCR for the Potential Treatment of CNS
Disorders
Carolyn Dzierba
9:45 AM
Neural Functions of SREB - The Most Evolutionarily Conserved
G-Protein Coupled Receptor Family Associated With Psychiatric
Disorders
Mickey Matsumoto
PA
153
11/10/15 9:58 AM
8:00 AM - 10:30 AM
Study Group
Great Hall 5-6
Addictions Neuroclinical Assessment: The Search Continues
Chair: David Goldman
Co-Chair: Laura Kwako
Participants:
Harriet de Wit
Vijay Ramchandani
Melanie Schwandt
Barbara Mason
Valerie Voon
Moderator: David Goldman
SG
154
11/10/15 9:58 AM
12:00 PM – 1:15 PM
Mini-Panel
Regency Ballroom 1
Revisiting the Mu Opiate Receptor
for the Treatment of Depression
Chair: Rene Hen
12:00 PM
Opioid Receptors and Mood
Brigitte Kieffer
12:25 PM
The Antidepressant-Like Effects of Tianeptine Are Mediated by
the Mu Opiate Receptor
Rene Hen
12:50 PM
Evaluation of Agonist-Antagonist Opioid Modulation With
ALKS-5461 in Major Depressive Disorder
Elliott Ehrich
MP
155
11/10/15 9:58 AM
1:15 PM – 2:30 PM
Mini-Panel
Regency Ballroom 1
DBS and the Identification of Circuits Mediating Depression
Chair: Fritz Henn
1:15 PM
Using DBS to Define Circuits Mediating Depression
Wayne Goodman
1:40 PM
Delineating Alterations of Brain Circuitry Due to Lateral
Habenula DBS in TRD
Alexander Sartorius
2:05 PM
Refined Methods for Subcallosal Cingulate DBS Targeting Using
Network-Specific Structural Connectivity Maps
Helen Mayberg
MP
156
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Panel
Diplomat 1 - 2
The Re-Emergence of Serotonergic Hallucinogens
as Tools for Neuropsychopharmacology
Chair: David Nichols
12:00 PM
Regulation of 5-HT2A Receptor-Induced Behavioral Responses
by mGlu2/3 and mGlu5 Receptors
Adam Halberstadt
12:35 PM
Mood, Craving, and Self-Efficacy in Psilocybin-Assisted
Treatment of Alcoholism
Michael Bogenschutz
1:10 PM
A Single Dose of Psilocybin Produces Substantial and Enduring
Decreases in Anxiety and Depression in Patients With a LifeThreatening Cancer Diagnosis: A Randomized Double-Blind
Trial
Roland Griffiths
1:45 PM
Results of a Multi-Modal Neuroimaging Study of LSD and a
Psilocybin for Treatment-Resistant Depression Clinical Trial
Robin Carhart-Harris
PA
157
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Panel
Regency Ballroom 3
Beta Arrestin Signaling: An Avenue to Novel
Psychopharmacology
Chair: Marc Caron
Co-Chair: Patricio O’Donnell
12:00 PM
Physiological Responses to Mu Opioid Receptor Agonists
Promoting Bias Toward G Protein Signaling Pathways
Laura Bohn
12:35 PM
A Unique Dual Cortico-Striatal Action of a Beta-Arrestin Biased
Dopamine D2 Receptor Ligand
Nikhil Urs
1:10 PM
D2 Beta Arrestin-Signaling Enhances Prefrontal Cortical
Interneuron Activity
1:45 PM
Novel Cellular Mechanisms Underlying Actions of Dopamine
D2 Receptors on Prefrontal Pyramidal Neurons
Vikaas Sohal
PA
158
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Panel
Regency Ballroom 2
Novel Molecular Targets in Cocaine Addiction
Chair: Ryan LaLumiere
12:00 PM
Acid Sensing Ion Channel: A New Player in Addiction-Related
Behavior
John Wemmie
12:35 PM
Regulation of Protein Translation in the Nucleus Accumbens
Marina Wolf
1:10 PM
Cocaine-Induced Adaptations in Astrocyte-Neuron
Communication Mediate Cocaine Seeking
Kathryn Reissner
1:45 PM
Corticosterone Potentiates Cocaine-Induced Reinstatement
of Drug Seeking by Inhibiting OCT3-Mediated Dopamine
Clearance in the Nucleus Accumbens
Paul Gasser
PA
159
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Panel
Atlantic Ballroom 1
Visualizing Neurocircuit Dynamics in Rodent
Models of Addiction and Anxiety
Chair: Garret Stuber
12:00 PM
Neural Activity in Processing Positive and Negative Valence
Kay Tye
12:35 PM
Visualization of a Feeding Authorization Mechanism
Christian Luscher
1:10 PM
Neural Substrates of Anxiety-Like Behavior in the Prefrontal
Cortex
Ilana Witten
1:45 PM
Imaging Network Dynamics to Rewards and Predictive Stimuli
in VTA and PFC Circuits
Garret Stuber
PA
160
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Panel
Atlantic Ballroom 2
Translational Neural Network Approaches for Identifying
Individualized Targets for Neurostimulation in Mood Disorders
and OCD
Chair: Kelvin Lim
12:00 PM
Cortical Nodes in the Ventrolateral Prefrontal and Anterior
Cingulate Cortex and the Functional Segmentation of the
Internal Capsule: Implications for Potential Treatment Targets for
Psychiatric Disease
Suzanne Haber
12:35 PM
Associations Between Distinct Patterns of Reward Circuitry
Function and Impulsive Sensation Seeking Provide Novel
Neural Targets for Transcranial Direct Current Stimulation as an
Intervention to Reduce Risk-Taking Behaviors
Mary Phillips
1:10 PM
Mapping Functional Connectivity Networks in the Individual
Hesheng Liu
1:45 PM
DBS Electrode Position and Clinical Outcomes in the Context of
Tractography
Benjamin Greenberg
PA
161
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Panel
Atlantic Ballroom 3
New Twists on Transmembrane Transporter Function in
Psychiatric and Neurodegenerative Disorders
Chair: Lynette Daws
Co-Chair: Ulrik Gether
12:00 PM
Missense Mutations in the Dopamine Transporter Gene:
Commonality Between Neuropsychiatric and Neurodegenerative
Diseases?
Ulrik Gether
12:35 PM
An Inside Job: Endosomal Na+/H+ Exchangers in Autism and
Neurological Disorders
Rajini Rao
1:10 PM
Unraveling Mechanisms Contributing to Lack of Antidepressant
Efficacy in Juveniles and Adolescents: Are Organic Cation
Transporters to Blame?
Lynette Daws
1:45 PM
Towards Chemical Screening of Antidepressant Efficacy via
Voltammetric Characterization of in Vivo Serotonin Clearance
Parastoo Hashemi
PA
162
11/10/15 9:58 AM
12:00 PM - 2:30 PM
Study Group
Great Hall 5-6
Methodological Challenges in Human Pharmacogenetic Studies
in Alcohol and Drug Abuse – What has Early Experience Taught
Us, Where to Next?
Chair: Raymond Anton
Co-Chair: Henry Kranzler
Participants:
Nassima Ait-Daoud
Lara Ray
Elliot Stein
Kent Hutchison
David Goldman
SG
163
11/10/15 9:58 AM
Notes
164
11/10/15 9:58 AM
Poster Session I – Monday, December 7, 2015
Advocacy Affiliate – National Alliance on Mental Illness (NAMI):
Building Better Lives for the Millions of Americans Affected by Mental
Illness
Charles R. Harman*
M0.
2015 Membership Advisory Task Force: Demystifying the ACNP
Membership Application Process
Christina Barr, Vaishali Bakshi, Elisabeth Binder, Melissa Brotman,
Raymond Cho, Cynthia Crawford, Erika Forbes, Margaret Haney,
Daniel Mueller, James Murrough, Srijan Sen, Philip Szeszko, Karen
Szumlinski, Kay Tye, Aristotle Voineskos
M1.
Changes in the Functional Brain Connectivity and Verbal Memory
Performance Following Yoga or Memory Training in Older Adults With
Subjective Memory Complaints
Helen Lavretsky*, Hongyu Yang, Harris Eyre, Amber Leaver,
Katherine Narr, Dharma Khalsa
M2.
Mental Healthcare Access and the Under-Served: Are Our State-of-theArt Treatments Getting to Those who Need it Most?
Daniel Jimenez*, Benjamin Cook, Margarita Alegria, Stephen
Bartels, Charles Reynolds, Philip Harvey
M3.
Depletion of Sex Steroid Hormones in Mid-Life Alters Hippocampal
Activity During Verbal Memory Encoding: A Population-Based fMRI
Study of Sex Differences in Memory Decline
Emily Jacobs*, Blair Weiss, Dorene Rentz, Sue Whitfield-Gabrieli,
Anne Remington, Harlyn Aizley, Anne Klibanski, Jill Goldstein
M4.
Positive Effects of Chronic but Not Acute Estradiol on CholinergicRelated Cognitive Performance in Postmenopausal Women
Savannah Boyd, Julie Dumas, Magdalena Naylor, Joon Hyuk Park,
Christiane Thiel, Paul Newhouse*
165
11/10/15 9:58 AM
Poster Session I—Monday
M5.
Severity of Early Life Stress Predicts Thalamic Hyperconnectivity
and Multiple Network Disruption: A Transdiagnostic Study of Global
Connectivity
Noah Philip*, Audrey Tyrka, Sarah Albright, Lawrence Sweet,
Lawrence Price, Linda Carpenter
M6.
Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in
Fear Learning
Raül Andero Gali*, Sarah Daniel, Jidong Guo, Donnald Rainnie,
Kerry Ressler
M7.
Validation of the Negative Sequelae of Trauma (NeST) Model: A
Dimensional Approach to Studying the Neurobiology of Post-Traumatic
Stress
Jennifer Stevens*, Renuka Reddy, Ye Ji Kim, Tanja Jovanovic, Kerry
Ressler
M8.
Does the ‘Not Just Right Experience’ (NJRE) in Obsessive-Compulsive
Disorder Denote a Neurodevelopmental Dimension Characterised by
Abnormal Sensory Processing?
Josselyn Hellriegel, William Mandy, Caroline Barber, Maheshi
Wikramanayake, Naomi Fineberg*
M9.
Plasticity of MAOA Methylation: An Epigenetic Correlate of Therapy
Response in Panic Disorder?
Christiane Ziegler, Jan Richter, Marina Mahr, Agnes Gajewska,
Thomas Lang, Paul Pauli, Winfried Rief, Tilo Kircher, Volker Arolt,
Alfons Hamm, Jürgen Deckert, Katharina Domschke*
M10. Within-Session Salivary Cortisol Reactivity During Psychotherapy is
Associated With Treatment Outcome for Posttraumatic Stress Disorder
Rebecca Sripada*, Anthony King, Israel Liberzon, Sheila Rauch
M11. Signaled Avoidance Learning Recruits a Prefrontal-Hippocampal System
for the Suppression of Innate Defensive Behavior
Justin Moscarello*, Joseph LeDoux
166
11/10/15 9:58 AM
M12. Sex- and Sert-Mediated Differences in Stimulated Serotonin Revealed
by Fast Microdialysis
Hongyan Yang, Maureen Sampson, Damla Senturk, Anne Andrews*
M13. Interleukin-6 as a Peripheral Fear Signal and a Regulator of Fear
Memory Maintenance
Matthew Young*, Leonard Howell
M14. Limbic and Hypothalamic Intrinsic Connectivity Correlates With
Cortisol Reactivity to Stress in Inhibited Children
Jacqueline Clauss*, Uma Rao, Jennifer Blackford
M15. Amygdala Endocannabinoids Promote Resiliency to Traumatic Stress
Exposure
Rebecca Bluett, Haymer Andre, Baldi Rita, Sachin Patel*
M16. Cortical Glx Concentrations in Cholecystokinine-Tetrapeptide (CCK-4)
Induced Panic
Peter Zwanzger*, Katharina Domschke, Tillmann Ruland, Maxim
Zavorotnyy, Swantje Notzon, Harald Kugel, Bettina Pfleiderer
M17. Olfactory Challenge Test in Combat Veterans: Evidence for Enhanced
Olfactory-Visual Functional Connectivity With Avoidance and
Hyperarousal Symptoms in PTSD
Bernadette Cortese*, Patrick McConnell, Brett Froeliger, Kimberly
Leslie, Qing Yang, Thomas Uhde
M18. Pilot Trial of a Brief Course of Exposure-Based CBT in Extending IV
Ketamine’s Effects in OCD
Carolyn Rodriguez*, Michael Wheaton, Jordana Zwerling, Shari
Steinman, Danae Sonnenfeld, Hanga Galfalvy, Helen Simpson
M19. PTSD Severity is Associated With Anterior Hippocampal
Dysconnectivity: A Graph-Based Whole-Brain Data-Driven Analysis
Chadi Abdallah*, Kristen Wrocklage, Brian Schweinsburg,
Christopher Averill, Marcia Trejo, Alicia Roy, Brenda Martini,
Steven Southwick, John Krystal, J. Cobb Scott
167
11/10/15 9:58 AM
M20. Relevance and Function of Long Non-Coding RNAs in Fear Memory
Formation
Torsten Klengel*, Kerry Ressler
M21. Pharmacotherapy Relapse Prevention With Escitalopram in Body
Dysmorphic Disorder: A Double-Blind Placebo-Controlled Trial
Katharine Phillips*, Aparna Kesheviah, Darin Dougherty, Robert
Stout, William Menard, Sabine Wilhelm
M22. Lower Posterior Cingulate Cortex Glutathione Levels in ObsessiveCompulsive Disorder
Brian Brennan*, J. Eric Jensen, Christine Perriello, Harrison Pope,
James Hudson, Scott Rauch, Marc Kaufman
M23. Modeling Cognitive Therapy in Rats: Fear Extinction Reverses the
Chronic Stress-Induced Shift From Active to Passive Coping Behavior
Elizabeth Fucich*, Madeleine Saunders, David Morilak
M24. Brain Markers of Late Adolescent Academic Functioning
Alejandro Meruelo*, Joanna Jacobus, Erick Idy, Tam Nguyen-Louie,
Susan Tapert
M25. Human Perinatal Choline Supplementation Decreases Preschool ParentReported Attentional and Social Withdrawral Symptoms via an Alpha7
Nicotinic Receptor Mediated Effect on Infant Development of Sensory
Gating
Randal Ross*, Sharon Hunter, M. Camille Hoffman, Lizbeth
McCarthy, Betsey Chambers, Amanda Law, Sherry Leonard, Gary
Zerbe, Robert Freedman
M26. Neural Network Predictors and Correlates of PTSD Symptom Reduction
During TF-CBT Among Adolescent Girls With PTSD
Joshua Cisler*, Ben Sigel, Karin Vanderzee, Joy Pemberton, Teresa
Kramer, Clinton Kilts
168
11/10/15 9:58 AM
M27. Volume Reduction in the Associative Striatum in Adolescents at Genetic
Risk for Schizophrenia
James Levitt*, Laura Levin-Gleba, Kelsey Smith, Nikos Makris,
Stephen Faraone, Ming Tsuang, Martha Shenton, Larry Seidman
M28. Effects of Binge-Like Exposure to Alcohol on Cognitive Flexibility and
Dopaminergic Neurotransmission in the Adult Prefrontal Cortex
Heather Trantham-Davidson*, Sam Centanni, Garr Sarah Corrin, L.
Judson Chandler
M29.Withdrawn
M30. Transcranial Magnetic Stimulation Potentiates Glutamatergic
Neurotransmission in Depressed Adolescents
Paul Croarkin*, Paul Nakonezny, Christopher Wall, Lauren Murphy,
Shirlene Sampson, Mark Frye, John Port
M31. Prenatal Stress Induces Maturational Delay in Dorsal Forebrain
Inhibitory Cell Populations Postnatally
Stephanie Lussier, Hanna Stevens*
M32. Enhanced Fronto-Subcortical Connectivity Following Childhood
Adversity as a Protective Mechanism Against Internalizing in
Adolescence
Ryan Herringa*, Cory Burghy, Diane Stodola, Michelle Fox, Richard
Davidson, Marilyn Essex
M33. Adolescent Social Stress Produces an Enduring Activation of the Locus
Coeruleus and Impairs its Communication With the Prefrontal Cortex
Gerard Zitnik*, André Curtis, Susan Wood, Jay Arner, Rita Valentino
M34. In Utero Exposure to Clinically Relevant Concentrations of Paliperidone
Does Not Affect Several Measures of Development or Early Measures of
Cognition in Rats
Michael Owens*, Susan Plott, Faketa Zejnelovik, Zachary Stowe,
Becky Kinkead
169
11/10/15 9:58 AM
M35. Early-Life Exposure to the SSRI Paroxetine Disrupts DNA Methylation
in the Early Postnatal Hippocampus
Sarah Clinton*, Matthew Glover, Nateka Jackson, Chelsea McCoy
M36. Characterization of Olfactory and Gait Behaviors in the BALB/c Mouse
Model of Autism Spectrum Disorders
Jessica Burket, Chelsea Young, Andrew Benson, Torrian Green,
Stephen Deutsch*
M37. CNV Analysis and Exome Sequencing in Japanese Autism Spectrum
Disorder Subjects
Kazuhiko Nakamura*, Ismail Thanseem, Norio Mori, Masatsugu
Tsujii, Naomich Matsumoto
M38. Suppression of Autistic Self-Injurious Behavior by Deep Brain
Stimulation
Andrew Chang, Victoria Berges, Jerome Chung, Gene Fridman, Jay
Baraban, Irving Reti*
M39. Childhood Maltreatment and Methylation of FKBP5
Kathryn Ridout*, Stephanie Parade, Alison Paquette, Camen Marsit,
Ronald Seifer, Audrey Tyrka
M40. Childhood Poverty Affects Brain White Matter Integrity
James Swain*, Yu Fang, Pilyoung Kim, Israel Liberzon, Gary Evans
M41. Characterization of Cognitive Function With the Cantab in Individuals
With Amnestic MCI in Relation to Hippocampal Volume, Amyloid
and Tau Status: Preliminary Baseline Results From the PharmaCog/
European-ADNI Study
Pradeep Nathan*, Giovanni Frisoni, On behalf of Pharmacog
Investigators
M42. Chemogenetic Suppression of Neural Activity in Dorsolateral Prefrontal
Cortex Impairs Spatial Working Memory in Rhesus Monkeys
Wendy Schnebelen, Philip Browning, Paula Croxson, Peter
Rudebeck, Stephen Brookshire, Mark Baxter*
170
11/10/15 9:58 AM
M43. The Alzheimer’s Prevention Initiative Genetic Testing, Disclosure and
Counseling Program
Jessica Langbaum, Jason Karlawish, J. Scott Roberts, Beth McCarty
Wood, Scott Kim, Angela Bradbury, Linda Patrick-Miller, Deborah
Blacker, Richard J. Caselli, Gary Marchant, Doris Zallen, Carolyn
Langlois, Trisha Walsh, Nellie High, Eric M. Reiman, Pierre Tariot*
M44. Prenatal Exposure to Toxoplasmosis and Risk for Childhood Autism
Marisa Spann*, Andre Sourander, Heljä-Marja Surcel, Susanna
Hinkka-Yli-Salomäki, Alan Brown
M45. Age-Related Differences on Cognitive Functions of Children and
Adolescents With Typical and Atypical Development: Results From a
Large Community-Based Study
Giovanni Salum*, Pedro Pan, Rodrigo Bressan, Gisele Manfro,
Euripedes Miguel, Luis Rohde
M46. Preclinical Evidence to Demonstrate That Lisdexamfetamine Prevents
Impulsivity in Binge-Eating
Peter Hutson*, S. Vickers, S. Goddard, M. Hallam, R. Brammer, D.
Heal
M47. A Double-Blind, Placebo-Controlled, Randomized-Withdrawal Study of
Lisdexamfetamine Dimesylate in Adults With Moderate to Severe Binge
Eating Disorder
James Hudson*, Susan McElroy, Celeste Ferreira-Cornwell, Jana
Radewonuk, Maria Gasior
M48. Reduced Expression of GAD65/67 mRNA and Dopamine D1 and D2
Receptors in Binge-Eating Rats
F.I. Tarazi*, Y.K. Choi, J. Gosden, D.J. Heal, P.H. Hutson
M49. Women Remitted From Anorexia Nervosa Have Aberrant Baseline
Cerebral Blood Flow in Gustatory and Homeostatic Neural Circuitry in
Response to Hunger
Christina Wierenga*, Amanda Bischoff-Grethe, Grace Rasmusson,
Ursula Bailer, Tom Liu, Walter Kaye
171
11/10/15 9:58 AM
M50. Structural and Functional Brain Development in Adolescents With
Bulimia Nervosa
Rachel Marsh*, Zhishun Wang, Mihaela Stefan, Xiao Yang
M51. A Double-Blind, Placebo-Controlled Trial of N-Acetyl Cysteine in the
Treatment of Skin Picking Disorder
Jon Grant*, Sarah Redden, Eric Leppink, Samuel Chamberlain,
Brian Odlaug
M52. Internet Addiction: A Meaningful Disorder? Associations With
Impulsivity and Compulsivity in a Large-Scale International Study
Samuel Chamberlain*, Konstantinos Ioannidis, Eric Leppink, Sarah
Redden, Christine Lochner, Jon Grant
M53. Low Coverage Whole Genome Sequencing of a Native American
Community Sample Reveals Single Nucleotide Polymorphisms Near
CTNNA2 Associated With Impulsivity
Cindy Ehlers*, Ian Gizer, Chris Bison, Wendy Slutske, Qian Peng,
Nicholas Schork, Kirk Wilhelmsen
M54. In Vivo Evaluation in Monkey Brain of the COX-1 and COX-2 Selective
Positron Emission Tomographic Radioligands [11C]PS13 and [11C]
MC1
Stal Shrestha*, Michelle Cortes, Prachi Singh, Kimberly Jenko,
Robert Gladding, Cheryl Morse, Sami Zoghbi, Masahiro Fujita,
Victor Pike, Robert Innis
M55. Efficacy of Lurasidone in Bipolar Depression: Population ExposureResponse Relationships in Patients With Bipolar Depression
Sunny Chapel, Yu-Yuan Chiu, Jay Hsu, Josephine Cucchiaro*,
Antony Loebel
M56. Efficacy of Lurasidone in Major Depression With Mixed Features:
Pattern of Improvement in Depressive and Manic Symptoms
Andrew Nierenberg, Joyce Tsai*, Yongcai Mao, Andrei Pikalov,
Trisha Suppes, Antony Loebel
172
11/10/15 9:58 AM
M57. Witnessing Social Defeat Stress Induces a Depression-Like Phenotype in
Female c57BL/6 Mice
Sergio Iniguez*, Lace Riggs, Francisco Flores-Ramirez, Jason
Alipio, Mary Kay Lobo
M58. Low Serotonin 1B Receptor Binding Potential in the Anterior Cingulate
Cortex in Drug-Free Patients With Recurrent Major Depressive Disorder
Mikael Tiger, Lars Farde, Christian Rück, Andrea Varrone, Anton
Forsberg, Nils Lindefors, Christer Halldin, Johan Lundberg*
M59. CYP2C19 Predicts Response to Tricyclic Antidepressants in Affective
Disorders
Maju Koola*, Kopal Tandon, Mark Kinirons, Magnus IngelmanSundberg, Michael Gill, Peter McGuffin, Robert Kerwin, Katherine
Aitchison
M60. Effects of Serotonin-Transporter-Linked Polymorphic Region and
Familial Depression Risks on DMN Connectivity
Jiook Cha*, Jay Gingrich, Myrna Weissman, Jonathan Posner
M61. Ketamine as a Prophylactic Against Stress-Induced Depressive-Like
Behavior
Christine Denny*, Rebecca Brachman, Josephine McGowan,
Jennifer Perusini, Sean Lim, Thu Ha Pham, Charlene Faye, Alain
Gardier, Indira Mendez-David, Denis David, René Hen
M62. R-Ketamine: A Rapid Onset and Sustained Antidepressant Without
Psychotomimetic Side Effects
Kenji Hashimoto*, Chun Yang, Ji-Chun Zhang, Qian Ren, Min Ma,
Wei Yao, Dong Chao, Yukihiko Shirayama
M63. Developing a Model to Predict the ACTH Response to a Social Stressor
Using Clinical Variables and Genotype
Cortney Turner*, Megan Hagenauer, Shweta Ramdas, Stefanie
Mayer, Jun Li, Elizabeth Young, Stanley Watson, James Abelson,
Huda Akil
173
11/10/15 9:58 AM
M64. Long-Lasting Alterations in Microglial HMGB1 Expression Correlates
With Increased Vulnerability to Depressive-Like Behaviors After
Chronic Unpredictable Stress
Tina Franklin*, Eric Wohleb, Ronald Duman
M65. Ziprasidone Augmentation of Escitalopram for Major Depressive
Disorder: Safety and Tolerability
George Papakostas*, Maurizio Fava, David Mischoulon, Richard
Shelton
M66. Regulation of Mood and Emotion Processing by GSK3 and FXR1P
Thomas Del’Guidice, Antonio Rampino, Jivan Khlghatyan,
Camille Latapy, Giuseppe Blasi, Alessandro Bertolino, Jean-Martin
Beaulieu*
M67. Lipid Peroxidation and Executive Function in Adolescent Bipolar
Disorder: The Role of BDNF
Benjamin Goldstein*, Dwight Newton, Daniel Dickstein, Melanie
Naiberg, Ana Andreazza
M68. Comparing the Effects of an Index Course of Magnetic Seizure Therapy
and Electroconvulsive Therapy on Quality of Life
Shawn McClintock*, Matthew Pierson, Alaattin Erkanli, Zhi-De
Deng, Bruce Luber, Mustafa Husain, Sarah Lisanby
M69. The Relationship Between Plasma Omega-3 Polyunsaturated Fatty Acid
Levels and Depressive Symptom Severity
E. Sherwood Brown*, Laura F. DeFina, Huy Ly, Prabha Sunderajan,
Haekyung Jeon-Slaughter
M70. Ketamine-Induced Changes in [11C]ABP688 Binding in Healthy and
Depressed Human Subjects
Irina Esterlis*, Nicole DellaGioia, Gerard Sanacora, Chadi Abdallah,
David Matuskey, John Krystal, Ramin Parsey, Richard Carson,
Christine DeLorenzo
174
11/10/15 9:58 AM
M71. Impact of Vortioxetine on Functional Capacity in MDD Patients With
Subjective Cognitive Dysfunction: Performance on the University of
California San Diego Performance-Based Skills Assessment (UPSA)
William Jacobson*, Philip Harvey, Elizabeth Merikle, Wei Zhong,
George Nomikos, Christina Kurre Olsen, Michael Cronquist
Christensen
M72. Test-Retest Reliability and Effects of Repeated Testing and Satiety on
Performance of an Emotional Test Battery
Colin Dourish*, Jason Thomas, Suzanne Higgs
M73. Ketamine is Antidepressant and Enhances Neuropeptide Y Expression in
Hippocampus and Frontal Cortex of a Serotonin Transporter Knock-Out
Rat Model
Aleksander Mathe*, Andrej Nikosjkov, Vasco Sousa, Christina
Weide-Fischer, Andreas Lennartsson, Gregers Wegener, Per
Svenningsson
M74. Rapid Ultrasensitive High Precision LC-MS Assays Identify Unique
Neuroactive Steroid and GABA Profiles in Women At-Risk for
Postpartum Depression
Kristina Deligiannidis*, Aimee Kroll-Desrosiers, Shunyan Mo,
Hien Nguyen, Abby Svenson, Nina Jaitly, Janet Hall, Bruce Barton,
Anthony Rothschild, Scott Shaffer
M75. Social Stress Impacts the Pathogenesis of SIV Infection and Treatment
Response
Gretchen Neigh*, Kelly Ethun, Emily Cartwright, Colleen McGary,
Luca Micci, Mirko Paiardini, Guido Silvestri, Ann Chahroudi
M76. Diversity of Reporter Expression Patterns in Transgenic Mouse Lines
Targeting Corticotropin Releasing Hormone-Expressing Neurons
Tallie Z. Baram*, Jenny Molet, Ben Gunn, Kerry Ressler, Yuncai
Chen
175
11/10/15 9:58 AM
M77. Role of AMPA Receptor Stimulation in the mPFC and Subsequent
Serotonin Neuron Activation in Antidepressant Effects of an mGlu2/3
Receptor Antagonist and Ketamine
Shigeyuki Chaki*, Kenichi Fukumoto, Michihiko Iijima
M78. Affective Neurodynamics Predict Depression Treatment Response
Aaron Heller*, Tom Johnstone, Michael Peterson, Greg Kolden, Ned
Kalin, Richard Davidson
M79. GPR139, an Orphan Receptor Highly Enriched in the Habenula and
Septum, is Activated by the Essential Amino Acids L-Tryptophan and
L-Phenylalanine
Pascal Bonaventure*, Changlu Liu, Grace Lee, Diane Nepomuceno,
Chester Kuei, Jiejun Wu, Qingqin Li, Victory Joseph, Steve Sutton,
William Eckert, Xiang Yao, Lynn Yieh, Curt Dvorak, Carruthers
Nicolas, Heather Coate, Sujin Yun, Christine Dugovic, Anthony
Harrington, Timothy Lovenberg
M80. Central Modulation of Parasympathetic Response to Negative Affect is
Disrupted in Major Depression: Impact of Sex
Ronald Garcia*, Klara Mareckova, Brandon Fluegel, Laura Holsen,
Harlyn Aizley, Anne Remington, Susan Whitfield-Gabrieli, Riccardo
Barbieri, Vitaly Napadow, Jill Goldstein
M81. Adjuvant Thiamine Improved Standard Treatment in Patients With
Major Depressive Disorder: Results From a Randomized, Double Blind,
and Placebo-Controlled Clinical Trial
Edith Holsboer-Trachsler*, Mohammad Haghighi, Leila Jahangard,
Dena Sadeghi Bahmani, Nadeem Kalak, Serge Brand
M82. First-Episode Bipolar Disorder is Associated With Erythrocyte
Membrane Docosahexaenoic Acid Deficits: Dissociation From Clinical
Response to Lithium or Quetiapine
Robert McNamara*, Thomas Blom, Jeffrey Welge, Jeffrey Strawn,
Caleb Adler, Melissa DelBello, Stephen Strakowski
176
11/10/15 9:58 AM
M83. Change in Incidence of Suicidal Behavior Among Antidepressant
Clinical Trial Participants: 1991-2013
Arif Khan*, James Faucett, Shirin Khan Schilling, Walter Brown
M84. Transglutaminase 2-Mediated Regulation of GABAA Receptor in
Depression
Chirayu Pandya, Diya Peter, Gustavo Turecki, Alvin Terry,
Anilkumar Pillai*
M85. Telomere Length as a Predictor of Response to Pioglitazone in Patients
With Unremitted Depression: A Preliminary Study
Natalie Rasgon*, Katie Watson Lin, Jue Lin, Elissa Epel, Maile
Jones, Siena Roat-Shumway, Elizabeth Blackburn
M86. A Randomized, Placebo-Controlled Adjunctive Trial of Riluzole in
Treatment-Resistant Major Depressive Disorder
Sanjay Mathew*, Maurizio Fava, Ralitza Guerguieva, Gerard
Sanacora
M87. What Doesn’t Kill You: Risk and Resilience for New Onset Depression
During the Menopause Transition
C. Neill Epperson*, Mary D. Sammel, Ellen W. Freeman
M88. Adjunctive Brexpiprazole (OPC-34712) in Patients With MDD and
Anxiety Symptoms: Results From Post-Hoc Analyses of Two Pivotal
Studies
Dusan Kostic*, Emmanuelle Weiller, Peter Zhang, Anna Eramo,
Ruth A. Duffy, Ross A. Baker, Catherine Weiss
M89. Using PET Imaging of Translocator Protein (TSPO) to Investigate the
Link Between Inflammation and Depression
Erica Richards*, Paolo Zanotti-Fregonara, Masahiro Fujita, Rodrigo
Machado-Vieira, Mark Niciu, Minkyung Park, Giacomo Salvadore,
Hartmuth Kolb, Carlos Zarate, Robert Innis
177
11/10/15 9:58 AM
M90. Behavioral and Neural Biomarkers of Improved Top-Down Control
During Ventral Capsule/Ventral Striatum Deep Brain Stimulation in
Major Depression
Alik Widge*, Samuel Zorowitz, Katherine Link, Wei Tang, Thilo
Deckersbach, Earl Miller, Darin Dougherty
M91. Neural Predictors of Treatment Response to Psychotherapy for
Depression in Bipolar Disorder
Thilo Deckersbach*, Rachel Franklin, Amy Peters, Jonathan Stange,
Andrew Peckham, Amanda Arulpragasam, Louisa Sylvia, Andrew
Nierenberg, Darin Dougherty
M92. Inhibition of Phosphodiesterase 2 Ameliorates Stress-Induced
Depression-Like Behaviors and Cognitive Deficits in Mice
Ying Xu*, Hanting Zhang, James O’Donnell
M93. A Genomewide Study of Suicidality in Bipolar Disorder
Clement Zai*, Arun Tiwari, Vincenzo De Luca, James Kennedy
M94. Central and Peripheral Effects of Acute Isolation Stress on Transforming
Growth Factor-Β1 and Cortisol in Nonhuman Primates
Srinath Gopinath*, Chadi Abdallah, Eric Smith, Olcay Batuman,
Jeffrey Margolis, Wei Chen, Bruce Scarf, Leonard Rosenblum,
Jeremy Coplan
M95. Cognitive Behavioral Therapy Increases Resting State Cognitive Control
Network Connectivity Across MDD and PTSD
Yvette Sheline*, Theodore Satterthwaite, Haochang Shou, Steven
Bruce, Charles Conway, Phillip Cook, Taki Shinohara
M96. Circuit-Wide Transcriptional Profiling Reveals Region Specific Gene
Co-Expression Networks Regulating Depression Susceptibility
Rosemary Bagot*, Hannah Cates, Immanuel Purushothaman,
Zachary Lorsch, Junshi Wang, Xiaojie Huang, Oliver Schlüter, Ian
Maze, Deena Walker, Catherine Peña, Elizabeth Heller, Orna Issler,
Minghui Wang, Won-min Song, Jason Stein, Xiaochuan Liu, Marie
Doyle, Rachel Neve, Daniel Geschwind, Yan Dong, Li Shen, Bin
Zhang, Eric Nestler
178
11/10/15 9:58 AM
M97. Cholinergic-Adrenergic Interaction in the Amygdala Regulates AnxietyAnd Depression-Like Phenotypes in Male and Female Mice: Effects of
Guanfacine following Cholinergic Dysregulation
Yann Mineur*, Emma Cahuzac, Matthew Bentham, Margreet
Platenga, Tenna Mose, David Thompson, Sherry McKee, Marina
Picciotto
M98. Brain Activation Correlates of Negative Attentional Bias in Depression
Jessica Ihne*, Allison Nugent, Maura Furey, Joanna Szczepanik,
Carlos Zarate
M99. Ankyrin-3 Bipolar Disorder GWAS Gene Regulates Activity of Dentate
Gyrus Granule Neurons and Adult Hippocampal Neurogenesis
Jacob Garza*, Klaudio Gjeluci, Melanie Leussis Leussis, Jennifer
Deniri, Tracey Petryshen
M100. A Randomized Trial of Internet-Based Cognitive Behavioral Therapy for
Major Depressive Disorder
Isabelle Rosso, Elizabeth Olson, William D. Scott Killgore, Rena
Fukunaga, Christian Webb, Scott Rauch*
M101. User-Centered Development and Field Testing of LiveWell: A Smart
Phone Application for Bipolar Disorder
Evan Goulding*, Cynthia Dopke, Tania Michaels, Monika Aneja,
Clair Martin, Andrew Bank, Mark Begale, David Mohr
M102. miRNA Dysregulation in Prefrontal Cortex by Chronic Corticosterone
Administration in Rats: Role in Depressive Disorder
Yogesh Dwivedi*, Bhaskar Roy
M103. Ziprasidone vs. Placebo Augmentation of Escitalopram for Patients With
vs. Without Anxious Depression
Dawn Ionescu*, Lee Baer, Richard Shelton, George Papakostas
M104. The Novel Short-Acting Kappa Opioid Receptor Antagonist LY2444296
Blocks Neuroendocrine and Behavioral Effects of Chronic but not Acute
Mild Stress in Rats
Marta Valenza*, Eduardo R. Butelman, Mary Jeanne Kreek
179
11/10/15 9:58 AM
M105. Identification of a Hormone-Modulated Hypothalamic Reward Circuit in
the Female Mouse
Jenna McHenry*, Zoe McElligott, James Otis, Kelson ShillingScrivo, Oksana Kosyk, Shanna Resendez, Hiroshi Nomura, Vijay
Mohan Namboodiri, Randall Ung, David Rubinow, Garret Stuber
M106. Comparison of Diffusion Kurtosis Imaging and Diffusion Tensor
Imaging Tractography Measures in Relation to Anhedonia in Young
Adults
Tsafrir Greenberg*, Amelia Versace, Henry Chase, Richelle Stiffler,
Jeanette Lockovich, Haris Aslam, Genna Bebko, Mary Phillips
M107. Adjunctive Brexpiprazole (OPC-34712) in Patients With Major
Depressive Disorder and Irritability: A Post-Hoc Analysis on Symptoms
of Anger
François Menard, Charlotte Kampp Davidsen, Emmanuelle Weiller,
Ross A. Baker*
M108. A Precision Medicine Approach to Antidepressant Treatment in
Depression
Gerard Dawson*, Colin Dourish, Guy Goodwin, Michael Brammer,
Catherine Harmer, Jonathan Kingslake, Michael Browning
M109. Neural and Hormonal Responses to Negative Affective Stimuli: Impact
of Sex and Depressed Mood
Klara Mareckova*, Laura Holsen, Roee Admon, Sue WhitfieldGabrieli, Jill Goldstein
M110. Zinc as a Mediator of Inflammation in the Brain: Implications for Mood
in Bipolar Disorder?
Caitlin Millett, Aubrey Reider, Brett Phillips, Shannon Kelleher,
Erika Saunders*
M111. Variation Does Matter - Fast BDNF Serum Level Increase and Diurnal
BDNF Oscillations are Associated With Therapeutic Response After
Partial Sleep Deprivation
Anne Eckert*, Johannes Beck, Serge Brand, Flavio Muheim, Maria
Giese, Ulrich Hemmeter, Martin Hatzinger, Edith Holsboer-Trachsler
180
11/10/15 9:58 AM
M112. Using the Cambridge Neuropsychological Test Automated Battery
(CANTAB) to Find Cognitive Markers of Vulnerability to Mental Illness
in Healthy Siblings of Bipolar Parents
Isabelle Bauer*, Mon-Ju Wu, Benson Irungu, Giovana Zunta-Soares,
Jair Soares
M113. Influence of Reproductive Hormones and Nighttime Hot Flashes on
Mood in Depressed Perimenopausal Women Reporting Stressful Life
Events
Hadine Joffe*, Sybil Crawford, Marlene Freeman, Geena Athappilly,
David Wolfe, Semmie Kim, Thania Galvan, Julia Camuso, Cathryn
Freid, Lee Cohen, Janet Hall
M114. Exponential State Transition Dynamics in the Rest-Activity Architecture
of Patients With Bipolar Disorder
Abigail Ortiz*, Kamil Bradler, Luiza Radu, Martin Alda, Benjamin
Rusak
M115. Automatic Detection of Social Rhythms in Bipolar Disorder via
Smartphone
Ellen Frank*, Saeed Abdullah, Mark Matthews, Tanzeem Choudhury
M116. Lymphoblast Cell Lines From Women With Premenstrual Dysphoric
Disorder (PMDD) Differ in mRNA and Protein Expression Profiles of
the ESC/E(Z) Pathway Compared With Asymptomatic Controls
Jessica Hoffman*, Neelima Dubey, Kornel Schuebel, Cheryl
Marietta, Qiaoping Yuan, Pedro Martinez, Lynnette Nieman, David
Rubinow, Peter Schmidt, David Goldman
M117. The Effect of IL-6 Neutralizing Agents on Depressed Mood and
Anhedonia in Immunology and Oncology Clinical Trials
Yu Sun, Dai Wang, Giacomo Salvadore, Jaskaran Singh, Benjamin
Hsu, Mark Curran, Corey Casper, Frits van Rhee, Jessica Vermeulen,
Ivo Caers, Justine Kent, Wayne Drevets, Husseini Manji, Guang
Chen, Gayle Wittenberg*
181
11/10/15 9:58 AM
M118. Phosphatidylcholines (PCs) in Major Depressive Disorder: A PlasmaBased Endophenotype Related to Inflammation
Emma Knowles*, Kevin Huynh, Joanne Curran, Jack Kent, Harald
Goring, Rene Olvera, Ravi Duggirala, Laura Almasy, John Blangero,
Peter Meikle, David Glahn
M119. Retrieval of Positive and Negative Associations Produces Opposite
Responses in BLA Neurons Projecting to NAc and CeA
Anna Beyeler*, Praneeth Namburi, Gordon Glober, Clémence
Simonnet, Garret Conyers, Robert Luck, Craig Wildes, Kay Tye
M120. Inflammation and Memory: Associations Among the CRP Gene, Serum
CRP, and Memory Performance
Negar Fani*, Heather Murray, Vasiliki Michopoulos, Kerry Ressler,
Bekh Bradley
M121. Contrasting Non-Linear Dynamic Analyses of EEG in Alert and Sedated
States
Teddy Akiki, Mark Doumit, Amira Zaylaa, Fadi Karameh, Ziad
Nahas*
M122. Differential Effects of Oxytocin on Social and Monetary Reward
Processing
Tiffany Love*, Joseph Heffernan, David Hsu, Brian Mickey
M123. A Novel Genetic Method of Measuring the Receptor-Specific
Component of PET Radioligand Binding in Human Brain Without
Pharmacological Blockade
Paolo Zanotti-Fregonara, Mattia Veronese, Rong Xu, Sami Zoghbi,
Jeih-San Liow, Masahiro Fujita, Victor Pike, Robert Innis*
M124. Becoming an Academic Researcher in Psychiatry: A View From the
Trenches
Carrie McAdams*, Dawn Ionescu, Aoife O’Donovan, Noah Philip
182
11/10/15 9:58 AM
M125. Glutamate Neurons in the Ventral Tegmental Area Co-Release GABA
and Promote Positive Reinforcement
Ji Hoon Yoo, Vivien Zell, Johnathan Wu, Reed Ressler, Alex
Johnson, Navarre Gutierrez-Reed, Thomas Hnasko*
M126. Notch Signaling in the Hypothalamic Arcuate Nucleus Controls
Differentiation of NPY, POMC and Kisspeptin Neurons
Paven Aujla*, Matthew Biehl, Lori Raetzman
M127. Do Religious Involvement and Religious Beliefs Protect Against
Suicidality as Assessed by the Sheehan-Suicidality Tracking Scale
Ahmad Hameed*, Amanda White, Michael Mitchell, Venkatesh
Basappa Krishnamurthy, Eric Youngstrom, Roger Meyer, Alan
Gelenberg
M128. Pregnenolone in the Treatment of Irritability in Autism Spectrum
Disorder: A Post-Hoc Metabolomic Analysis
Lawrence Fung*, Wenchao Sun, Robin Libove, Serena Tanaka,
Lauren Kwa, Jennifer Philips, Francois Haddad, Jayakumar Rajadas,
Antonio Hardan
M129. A Preclinical Evaluation of the Potential of CR845 to Induce Tolerance
and a Syndrome of Dependence on Withdrawal
David Heal*, Simon Goddard, Jane Gosden, Steve Dykes, Richard
Brammer, Robert Spencer, Frederique Menzaghi
M130. Super-Cholinergic Mice and Humans: Cholinergic-Cognitive-Affective
Resiliencies
Martin Sarter*, Cindy Lustig, Randy Blakely, Ajeesh KoshyCherian, Paulina Valuskova, Vinay Parikh, Youngsoo Kim, Natalie
Tronson, Elizabeth Ennis
M131. Neural Activity in Basolateral Amygdala Encodes Reward Magnitude
and Risk of Punishment in a Risky Decision-Making Task in Rats
Caitlin Orsini*, Marcelo Febo, Jennifer Bizon, Barry Setlow
183
11/10/15 9:58 AM
M132. Hormonal Contraception Diminishes Oxytocin-Induced Brain Reward
Responses in Women Viewing the Faces of Their Romantic Partners
Dirk Scheele, Jessica Plota, Birgit Stoffel-Wagner, Wolfgang Maier,
Rene Hurlemann*
M133. Regulation of Brain Susceptibility to Inflammatory Responses by
Protein S-Glutathionylation in Glia
Shin-ichi Kano*, Daniel Chang, Eric Choi, Brian Lo, Akira Sawa
M134. Evaluation of 5-HT2C Receptor in the Human Brain in Vivo: A [11C]
Cimbi-36 PET Study
Eugenii Rabiner*, Graham Searle, Jan Passchier, Yvonne Lewis,
Courtney Bishop, Rexford Newbould, David Nutt, Roger Gunn,
Gitte Knudsen
M135. Functional Independence of Brain Regions at Rest Broadly Predicts
Individual Differences in Higher-Order Cognition
G. Andrew James*, Tonisha E. Kearney-Ramos, Clinton D. Kilts,
Jonathan A. Young, Jennifer L. Gess, Jennifer S. Fausett
M136. Strain Dependency of the Effects of Nicotine and Mecamylamine in a
Rat Model of Attention
Britta Hahn*, Katelyn Riegger, Greg Elmer
M137. Input and Output-Specific Regulation of a Learned Action Sequence by
Corticostriatal Circuits
Patrick Rothwell*, Scott Hayton, Gordon Sun, Marc Fuccillo,
Byungkook Lim, Robert Malenka
M138. Erasure of Recent and Remote Fear Memory by Enhancing Forgetting
Through Increase in Adult Hippocampal Neurogenesis
Satoshi Kida*, Rie Ishikawa
M139. Aberrant Nocturnal Cortisol as a Vulnerability Trait for More Rapid
Progression of Advanced Breast Cancer
Jamie Zeitzer, Bita Nouriani, Michelle Rissling, George Sledge,
Oxana Palesh, Booil Jo, Eric Neri, David Spiegel*
184
11/10/15 9:58 AM
M140. Distinct Roles of Melanin Concentrating Hormone in Maternal Behavior
and Postpartum Depression
Amal Alachkar*, Lamees Alhassen, Zhiwei Wang, Olivier Civelli
M141. Impact of Metabolic Aberrations on Biophysical Integrity of the Default
Mode Network
Shaolin Yang, Minjie Wu, Olusola Ajilore, Melissa Lamar, Anand
Kumar*
M142. Selective Modulation of Forebrain Function
Jeffrey Witkin*, Akihiko Kato, David Bredt, Kevin Burris, Warren
Porter, Chunjin Ding, Scott Gleason, Hong Yu, Francesca Pasqui,
Emanuele Sher, Ruud Zwart, Eric Nisenbaum, Xingjie Ping, Jodi
Smith, Kevin Gardinier
M143. Patients Receiving Regular Oral Lithium Therapy Have a Reduced
Incidence of Severe Neurological Disease and Myocardial Infarction
Ronald Fieve*, James Prosser, Barbara Orlowski
M144. Comparing Dynamic SUV and Cortical Thickness Between Healthy
Controls and Epilepsy Patients Using Simultaneous PET/MR
Yu-Shin Ding*, Shaunak Ohri, Jean Logan, Harikrishna Rallapalli,
Thomas Koesters, James Babb, Orrin Devinsky
M145. NPI Agitation/Aggression Domain Scores Demonstrate Clinically
Meaningful Changes in a Phase 2 Study of Dextromethorphan/Quinidine
(DM/Q) in Patients With Agitation in Alzheimer’s Disease
Sanjay Dubé*, Jeffrey Cummings, Harry Cui, Joao Siffert
M146. [11C]Neuroflux: In Vivo Measurement of Neuron Population Flux
Genevieve Van de Bittner*, Misha Riley, Luxiang Cao, Janina
Ehses, Scott Herrick, Emily Ricq, Jaclyn Smith, Changning Wang,
Frederick Schroeder, Mark Albers, Jacob Hooker
M147. The Effects of Aging and Psychiatric Disease on Circadian Patterns of
Gene Expression in the Human Prefrontal Cortex
Cho-Yi Chen, Ryan Logan, Tianzhou Ma, David Lewis, George
Tseng, Etienne Sibille, Colleen McClung*
185
11/10/15 9:58 AM
M148. Gender Differences in the Clinical Features and Substance Use Disorder
Comorbidities in Patients With Antisocial Personality Disorder
Leo Sher*, Larry Siever, Marianne Goodman, Margaret McNamara,
Erin Hazlett, Harold Koenigsberg, Antonia New
M149. Cognitive Reappraisal Training Enhances Emotion Regulation in
Borderline Personality Disorder
Harold Koenigsberg*, Bryan Denny, Jin Fan, Marianne Goodman,
Antonia New, Mercedes Perez-Rodriguez, Antonia McMaster,
Heather Alexander, Liza Rimsky, Sarah Jo Mayson
M150. Low Activity Monoamine Oxidase-A Allelic Variants Relate to
Abnormal Amygdala Morphology in Antisocial Personality Disorder
With High Psychopathic Traits
Nathan Kolla*, Raihaan Patel, Mallar Chakravarty, Jeffrey Meyer
M151. Maintenance Antipsychotic Dose can be Decreased in Late-life
Schizophrenia: A Prospective DopamineD2/3 Receptor Occupancy
Study With [11C]-Raclopride
Shinichiro Nakajima*, David Mamo, Fernando Caravaggio,
Takefumi Suzuki, Hiroyuki Uchida, Philip Gerretsen, Wanna Mar,
Tarek Rajji, Benoit Mulsant, Bruce Pollock, Ariel Graff
M152. Selective Estrogen Modulation Increases Dorsolateral Prefrontal Cortex
Activity During Emotional Inhibition in Schizophrenia
Thomas Weickert*, Jochen Kindler, Rhoshel Lenroot, Peter
Schofield, Cynthia Shannon Weickert
M153. Comparison of Subjective Experiences Between Patients With
Schizophrenia and Bipolar Disorder Receiving Long-Acting Injectable
Antipsychotics
Shih-Ku Lin*, Wen-Yin Chen
M154. Effects of Extended Cannabis Abstinence on Clinical and Cognitive
Symptoms in Cannabis Dependent Patients With Schizophrenia and
Non-Psychiatric Controls
Rachel Rabin*, Michelle Goodman, Mera Barr, Tony George
186
11/10/15 9:58 AM
M155. Reduced Rostrolateral Prefrontal Cortex Activity Associated With
Exploration in Schizophrenia
James Waltz*, Ziye Xu, Rebecca Ruiz, Elliot Brown, Robert
Buchanan, James Gold
M156. Metabolic Safety of Cariprazine in Patients With Schizophrenia
Stephen Marder, Stephen Zukin, Kaifeng Lu, Marc Debelle, Suresh
Durgam*
M157. Development of AUT00206, a Novel and Selective Kv3 Channel
Modulator for the Treatment of Schizophrenia
Jo Neill*, Mike Harte, Ben Grayson, Samaneh Maysami, Steve
Williams, Shane McKie McKie, Bill Deakin, Marianne Leger,
Mark Cunningham, Fiona LeBeau, Claire Gillougley, Frank Tarazi,
Giuseppe Alvaro, Charles Large
M158. Efficacy and Safety of the Glycine Transporter Type-1 Inhibitor
AMG 747 for the Treatment of Negative Symptoms Associated With
Schizophrenia
Eduardo Dunayevich, Robert Buchanan, Chao-Yin Chen, Julie
Dietrich, Hong Sun, Stephen Marder*
M159. Central Dopamine D2/3 Receptor Occupancy Following Dose Reduction
is Predictable With Minimal Plasma Antipsychotic Concentrations: An
Open-Label Clinical Trial
Hiroyuki Uchida*, Shinichiro Nakajima, Robert Bies, Fernando
Caravaggio, Takefumi Suzuki, Eric Plitman, Wanna Mar, Philip
Gerretsen, Bruce Pollock, Benoit Mulsant, David Mamo, Ariel Graff
M160. Bi-Phasic Effect of Ketamine on Auditory Steady-State Response in
Awaking Rats
Takuma Mihara*, Sokichi Honda, Yuko Takahasi, Hiroshi Yamada,
Mickey Matsumoto
M161. Overexpression of a Schizophrenia-Associated Missense Mutation in
Kalirin-9 in Primary Neuronal Culture
Melanie Grubisha*, Michelle Richard, Zachary Wills, Theron
Russell, Kenneth Fish, Peter Penzes, Robert Sweet
187
11/10/15 9:58 AM
M162. Adolescent Suppression of Prefrontal Nicotinic Signaling Shapes
Attentional Function
Michael Demars, Jenna Short, Elisa Nabel, Hiroyuki Koike, Mark
Baxter, Hirofumi Morishita*
M163. Reduced Amplitude Low-Frequency BOLD Signal Oscillations in Early
Illness Schizophrenia Patients and Individuals at Clinical High Risk for
Psychosis
Susanna Fryer*, Brian Roach, Katherine Wiley, Rachel Lowey,
Judith Ford, Daniel Mathalon
M164. Altered Intrinsic Prefrontal Activity and Connectivity is Associated With
Impaired Cognitive Abilities in Patients With Schizophrenia
Fabio Ferrarelli*, Brady Riedner, Michael Peterson, Giulio Tononi
M165. A Unique Dual Cortico-Striatal Action of a Beta-Arrestin Biased
Dopamine D2 Receptor Ligand
Nikhil Urs*, Steven Gee, John McCorvy, Thomas Pack, Tama Evron,
Bryan Roth, Patricio O’Donnell, Marc Caron
M166. Effects of Endurance Training in Combination With Cognitive
Remediation in Multi-Episode Schizophrenia and Healthy Controls
Peter Falkai*, Berend Malchow
M167. Mortality and Cumulative Exposure to Antipsychotics, Antidepressants
and Benzodiazepines: An Observational Follow-Up Study
Jari Tiihonen*, Ellenor Mittendorfer-Rutz, Minna Torniainen,
Kristina Alexanderson, Antti Tanskanen
M168. Impact of Withdrawal From Haloperidol, Clozapine, or Aripiprazole
Treatment on Dopamine System Activity in MAM Rodent Model of
Schizophrenia
Kathryn Gill*, Susan Sonnenschein, Sarah Miller, Anthony Grace
M169. β-Arrestin Signaling Increases Excitability of Fast-Spiking Interneurons
in the Prefrontal Cortex
Steven Gee*, Patricio O’Donnell
188
11/10/15 9:58 AM
M170. Improvement in Depressive Symptoms Mediates Changes in Functional
Capacity in Schizophrenia: A Treatment Study
Philip Harvey*, Masaaki Ogasa, Cynthia Siu, Antony Loebel
M171. A Candidate Gene Analysis of Startle Latency in Schizophrenia and
Control Subjects: A Replication Study
Alicia K. Smith, Wendy Hasenkamp, Varun Kilaru, Bruce Cuthbert,
Robin Gross, Barbara Lewison, Lisette W. Swails, Amanda Green,
William Boshoven, Megan Keyes, Erica Duncan*
M172. Clozapine Treatment in Patients With Benign Neutropenia
Deanna L. Kelly*, Charles M. Richardson, Erica A. Davis, Gopal
R. Vyas, Bethany A. DiPaula, Heidi J. Wehring, Raymond C. Love,
Robert P. McMahon
M173. Lack of Face Selectivity for Putative Neural Marker of Face Processing
in Schizophrenia: Evidence From ERP and fMRI During Face Detection
Yue Chen*, Steve Maher, Yasmin Mashhoon, Tor Ekstrom, Scott
Lukas, Dost Ongur
M174. Rare Variants in the Neurotrophin Signaling Pathway Implicated in
Schizophrenia Risk
Thorsten Kranz*, Ray Goetz, Julie Walsh-Messinger, Deborah
Goetz, Daniel Antonius, Igor Dolgalev, Adriana Heguy, Marco
Seandel, Dolores Malaspina, Moses Chao
M175. Glutamate, Calcium-Channel and Dopamine Genes and Brain Glutamate
in Schizophrenia: A Proton Spectroscopic Imaging and Genetics Study
Juan Bustillo*, Veena Patel, Thomas Jones, Christopher Abbott, Jose
Canive, Charles Gasparovic, Jessica Turner
M176. Characterization of a Novel Dopaminergic Agonist That Displays Spatial
Bias and Functional Selectively at the D2 Dopamine Receptor
David Sibley*, R. Benjamin Free, J. Hoon Shin, Brittney Miller,
Trevor Doyle, Amy Moritz, Jennie Conroy, Tarsis Brust, Noel
Southall, Marc Ferrer, Prashant Donthamsetti, Jonathan Javitch,
Val Watts, Jonathan Katz, Gregg Stanwood, Jeremiah Bertz, James
Woods, Kyle Emmitte, Craig Lindsley, Veronica Alvarez
189
11/10/15 9:58 AM
M177. New Roles for Dopamine and Dopamine D2-Like Receptors in
Pancreatic Insulin Release: Implications for Antipsychotic Drug Action
Outside the Brain
Zachary Farino, Travis Morgenstern, Benjamin Inbar, Antonella
Maffei, Paul Harris, Prashant Donthamsetti, Robin Freyberg,
Christoph Kellendonk, Thue Schwartz, Claudia Schmauss, Jonathan
Javitch, Zachary Freyberg*
M178. Tyrosine Hydroxylase, GAD67, vGLUT1, and vGLUT2 Proteins in the
Substantia Nigra in Schizophrenia
Rosalinda Roberts*, Kirsten Schoonover, Lesley McCollum
M179. Cortical Dopaminergic Deficiency in Schizophrenia While Performing a
Cognitive Task: A PET Study
Naren Rao, Georg Northoff, Miran Kenk, Ivonne Suridjan, Alan
Wilson, Sylvain Houle, Antonio Strafella, Gary Remington, Romina
Mizrahi*
M180. Testing the “PACT” Strategy: Amphetamine (AMPH) Enhances Gains in
Auditory Discrimination Training in Adult Schizophrenia (SZ) Patients
Neal Swerdlow*, Melissa Tarasenko, Savita Bhakta, Jo Talledo,
Erica Hughes, Alexis Alvarez, Brinda Rana, Sophia Vinogradov,
Gregory Light
M181. Investigating Schizophrenia GWAS Risk Variants in Cognitive and Brain
Structural Defects in the GENUS Consortium Sample Collection
Gabriella Blokland, Tracey Petryshen*, T GENUS Consortium
M182. Optogenetic Assessment of Dynamic Input Integration in the Ventral
Striatum
Julie Brooks*, Patricio O’Donnell
M183. Shared Genetic Etiology Does Not Explain Differential Risk of Immune
Diseases in Schizophrenia
Jennie Pouget*, Buhm Han, James Kennedy, Jo Knight, Soumya
Raychaudhuri
190
11/10/15 9:58 AM
M184. A Translational Approach to Differentiate a Novel PDE4 Inhibitor, From
a PDE10 Inhibitor which Lacked Clinical Efficacy in Schizophrenia
Liam Scott, Radka Graf, Zoe Hughes*
M185. Region-Specific Dendritic Spine Loss of Pyramidal Neurons in
Dopamine Transporter Knockout Mice
Ichiro Sora*, Yosefu Arime, Frank Hall, George R. Uhl, Yoshiyuki
Kasahara
M186. The Novel Atypical Antipsychotic Brexpiprazole, Alone and in
Combination With Escitalopram, Facilitates Prefrontal Glutamatergic
Transmission via a Dopamine D1 Receptor-Dependent Mechanism
Monica Marcus*, Carl Björkholm, Åsa Konradsson-Geuken, Kent
Jardemark, Torgny Svensson
M187. Effect of Brexpiprazole on Agitation and Hostility in Patients With
Acute Schizophrenia
Leslie Citrome*, John Ouyang, Emmanuelle Weiller, Ross A. Baker,
Catherine Weiss
M188. The Transcription Factor Nuclear Factor-ΚB is a Molecular Hub of
Cortical Immune Activation in Schizophrenia
David Volk*, Jessica Edelson, Kaitlyn Roman, Annie Moroco, David
Lewis
M189. Exercise-Induced Effects on Neurocognition in Schizophrenia
Barbara Schwartz*, Theresa Teslovich, Xiaozhen You, Jae Cho, Nina
Schooler, Peter Kokkinos, Chandan Vaidya
M190. Are Antipsychotics Neurotoxic or Neuroprotective? A Long-Term
Comparison of Two Treatment Strategies: Study Design of the
Multicenter APIC Trial
Gerhard Gründer*
191
11/10/15 9:58 AM
M191. White Matter Neurons Numbers and Densities Across the Human
Lifespan, Including the Potential Role(s) of Antipsychotic Drugs
Tobias Halene*, Aslihan Dincer, Alexey Kozlenkov, Paula Croxson,
Amanda Mitchell, Yan Jiang, Cong Lin, Eustathia Giannaris, Yin
Guo, Adriana Akintobi, Andree Lessard, Patrick Hof, Panos Roussos,
Stella Dracheva, Scott Hemby, William Bunney, Schahram Akbarian
M192. Odor Deficits in Chronic Schizophrenia: Relationship to Cognition and
Symptoms
Robert Smith*, Mohammed Sharifi, Mary Youssef, Sanela Mattiuz,
Henry Sershen, Abel Lajtha, Jahanzeb Shaikh, Hua Jin, John Davis,
Alessandro Guidotti
M193. Switching Patients With Acute Schizophrenia to Brexpiprazole: PostHoc Analysis of a Double-Blind Randomized Maintenance Treatment
Study
Catherine Weiss*, John Ouyang, Anna Eramo, Ruth A. Duffy,
Emmanuelle Weiller, Ross A. Baker
M194. Oxidative Stress in the Pathophysiology of Psychiatric Disorders:
Studies of Patient Biospecimens and Animal Models
Minae Niwa*, Lindsay Hayes, Teppei Tanaka, Travis Faust, Daisuke
Fukudome, Tyler Cash-Padgett, Hanna Jaaro-Peled
M195. Complex Genetic Overlap Between Schizophrenia Risk and
Antipsychotic Response
Douglas Ruderfer*, Alexander Charney, Ben Readhead, Brian Kidd,
Anna Kahler, Paul Kenny, Michael Keiser, Jennifer Moran, Christina
Hultman, Stuart Scott, Patrick Sullivan, Shaun Purcell, Joel Dudley,
Pamela Sklar
M196. Dysregulation of the Actin Cytoskeleton Contributes to Dendritic Arbor
Pathology in Schizophrenia and Bipolar Disorder
Glenn Konopaske*, Darrick Balu, Kendall Presti, Francine Benes,
Joseph Coyle
192
11/10/15 9:58 AM
M197. DNA Methylation as a Mechanism for Altered Glutamatergic Signaling
in the Superior Temporal Gyrus of Individuals With Schizophrenia
Brandon McKinney*, Ying Ding, Matthew MacDonald, David
Lewis, Robert Sweet
M198. Prefrontal GABAergic and NMDA Glutamatergic Regulation of
Working Memory During Delayed Responding: Modulation by D1
Receptor Stimulation
Meagan Auger*, Juliet Meccia, Nicholas Chan, Stan Floresco
M199. Brain Bioenergetics Measured by 31P Magnetization Transfer
Spectroscopy in Unaffected First-Degree Relatives of Patients With
Psychotic Disorders
Virginie Anne Chouinard*, Fei Du, Kyle P. Ryan, Polly Huynh,
Xiaoying Fan, Jacqueline R. Goldbach, Guy Chouinard, Bruce M.
Cohen, Dost Ongur
M200. Human Factor Evaluation of a Novel Digital Health Feedback System in
Psychiatry
Timothy Peters-Strickland*, Ainslie Hatch, Jane Lea Smith,
Benjamin Bartfeld, Linda Pestreich, Shashank Rohatagi, Felicia
Forma, Praveen Raja, John Docherty
M201. Missense Mutations in Four Genes Underlie Phenotypically Distinct
Subtypes of Psychosis, Accounting for >30% of Cases in an Ethnically
Diverse Research Sample
Dolores Malaspina*, Thorsten Kranz, Karen Rothman, Adam Berns,
Jerry Shields, Raymond Goetz, Moses Chao
M202. Altered Temporal Patterns of Prefrontal BDNF During Decision Making
Shifts
Vinay Parikh*, Robert Cole
M203. Hyperactivation of Salience Network During Eye Gaze Perception in
Schizophrenia
Ivy Tso*, Beier Yao, Stephan Taylor
193
11/10/15 9:58 AM
M204. Cariprazine for Negative Symptoms of Schizophrenia: Pooled Post
Hoc Analysis of 2 Randomized, Double-Blind, Placebo- and ActiveControlled Trials
Willie Earley*, Suresh Durgam, Marc Debelle, István Laszlovszky,
Kaifeng Lu, Henry Nasrallah
M205. Effects of the Rapidly-Acting Antipsychotic Agent Sodium
Nitroprusside (SNP) on Synaptic Spine Function and Morphology in
Medial Prefrontal Cortex
Rong-Jian Liu, Catherine Duman, Ronald Duman, George
Aghajanian*
M206. Cariprazine as Monotherapy for the Treatment of Predominant Negative
Symptoms of Patients With Schizophrenia: A Double-Blind, Active
Comparator-Controlled Trial
Marc Debelle, Rene Kahn*, István Laszlovszky, Erzsébet Szalai,
György Németh, Balázs Szatmári, Judit Harsányi, Ágota Barabássy,
Suresh Durgam, Wolfgang Fleischhacker
M207. Abnormal Fucosylation-Associated Enzyme Expression in
Schizophrenia
Toni Mueller*, Stefani Yates, Vahram Haroutunian, James MeadorWoodruff
M208. Ketamine Induced NMDA-Receptor Blockade and Hippocampal
Nina Kraguljac*, Michael Frölich, Steve Tran, David White, Nona
Nichols, Meredith Reid, Adrienne Lahti
M209. Role of Locus Coeruleus-Ventral Tegmental Area Circuit in Mediating
the Resilience to Social Stress
Hongxing Zhang*, Dipesh Chaudhury, Barbara Juarez, Allyson
Friedman, Stacy Ku, Alexander Nectow, Marshall Crumiller, Cheng
Jiang, Song Zhang, Carole Morel, Stephen Salton, Jeffrey Friedman,
Jun-Li Cao, Ming-Hu Han
194
11/10/15 9:58 AM
M210. HPA Axis Dysregulation in Men With Hypersexual Disorder
Jussi Jokinen*, Andreas Chatzittofis, Jonas Hallberg, Katarina
Öberg, Peter Nordström, Stefan Arver
M211. The Amygdala Functionally Drives the Ventral-to-Dorsal Striatal Shift in
the Development and Maintenance of a Cocaine-Seeking Habit
Jennifer Murray*, Aude Belin-Rauscent, Chiara Giuliano, Barry
Everitt, David Belin
M212. NMDA Receptor GluN2D Subunit is Indispensable in Phencyclidine
(PCP) Effects
Kazutaka Ikeda*, Yoko Hagino, Shinya Kasai, Hideko Yamamoto,
Masayoshi Mishina
M213. Chronic Cocaine Exposure Alters Decision Making Through a D1
Medium Spiny Neuron Mechanism to Promote Relapse
Erin Calipari*, Rosemary Bagot, Immanuel Purushothaman, Thomas
Davidson, Jordan Yorgason, Catherine Pena, Deena Walker, Stephen
Pirpinias, Kevin Guise, Charu Ramakrishnan, Karl Deisseroth, Eric
Nestler
M214. Paternal Cocaine Exposure Elicits Learning Deficits in Male Progeny
Mathieu Wimmer*, Lisa Briand, Leonardo Guercio, Adrian Arreola,
Heath Schmidt, Chris Pierce
M215. A Selective Role for Mesolimbic Circuitry in Cognitive Deficits
Following Adolescent Alcohol Use
Jeremy Clark*
M216. Dopamine D2/3 Receptor Availability Associated With Simulated Drug
Choice in Methamphetamine Addiction
Scott Moeller*, Chelsea Robertson, Kyoji Okita, Michael Ballard,
Anna Konova, Rita Goldstein, Mark Mandelkern, Edythe London
M217. Whole Brain Mapping of Monosynaptic CB1 Receptor Inputs Into
Dopamine Neurons of the Ventral Tegmental Area
Vadim Kasthelyan, Carlos Mejias-Aponte, Marisela Morales, Joseph
Cheer*
195
11/10/15 9:58 AM
M218. Functional Heterogeneity Among Midbrain Dopamine Neurons in the
Control of Cue Attraction, Conditioned Locomotion, and Reinforcement
Benjamin Saunders*, Elyssa Margolis, Patricia Janak
M219. Genome-Wide Mapping of Ethanol Sensitivity in the Diversity Outbred
Mouse Population
Clarissa C. Parker*, Troy Wilcox, Dan Gatti, Eric Busch, Steven
Kasparek, Drew Kreuzman, Benjamin Mansky, Sophie Masneuf,
Erica Sagalyn, Kayvon Sharif, Dominik Taterra, Walter Taylor, Mary
Thomas, Elissa J. Chesler, Andrew Holmes
M220. How Does Cocaine Interfere With Brain Development?
William Freed*, Abigail Kindberg, Raphael Bendriem, Chen Jia,
Christopher Richie, Charles Spivak, Brandon Harvey, Chun-Ting
Lee
M221. Adolescent Cannabinoid Self-Administration in Rats: Effects on PFCDependent Working Memory, Protein Expression, and Indicators of
Abuse Liability
Mary Torregrossa*, Michael Pollock, Vidhya Nagarajan, Erin
Kirschmann
M222. Voluntary Consumption of Alcohol in Combination With Cocaine Alters
the Neurobiology Underlying Relapse to Cocaine-Seeking
Bethany Stennett, Lori Knackstedt*
M223. Reward Processing Across Addictive Disorders
Iris Balodis*, Sarah Yip, Hedy Kober, Patrick Worhunsky, Marney
White, Michael Stevens, Godfrey Pearlson, Rajita Sinha, Carlos
Grilo, Kathleen Carroll, Marc Potenza
M224. Getting Over It: A Longitudinal Neuroimaging Study Demonstrating the
Emergence of Executive Control Circuits in Treatment-Engaged Cocaine
Users and Alcoholics
Colleen Hanlon*, Logan Dowdle, Tonisha Kearney Ramos, Oliver
Mithoefer, Kathleen Brady, Joshua Smith
196
11/10/15 9:58 AM
M225. PKMζ Knockout Enhances Cocaine-Taking and Cocaine Seeking
Jeffrey Lenz, Lisa Briand*
M226. Involvement of Striatal Dopamine D2/D3 Receptors in the Modulation
of Visual Attention During Rested Wakefulness and Sleep Deprivation
Dardo Tomasi*, Gene-Jack Wang, Nora Volkow
M227. PET Imaging of TSPO Expression in Alcohol Dependent Subjects
During Acute Abstinence: Comparison With Healthy Control Subjects
Ansel Hillmer*, Christine Sandiego, Jonas Hannestad, Gustavo
Angarita-Africano, Kevin O’Connor, Nabeel Nabulsi, Jim Ropchan,
Shu-Fei Lin, Richard Carson, Stephanie O’Malley, Kelly Cosgrove
M228. Social Isolated DISC1 Mutant Mice Displayed High Sensitivity to
Chronic Cocaine Exposure and Rolipram Treatment
Takatoshi Hikida*, Makiko Morita, Mahomi Kuroiwa, Tom
Macpherson, Taichi Itou, Takahide Shuto, Naoki Sotogaku, Minae
Niwa, Akira Sawa, Akinori Nishi
M229. Hnrnph1 is a Quantitative Trait Gene for Methamphetamine Sensitivity
Neema Yazdani, Clarissa Parker, Ying Shen, Michael Guido, Loren
Kole, Stacey Kirkpatrick, Jackie Lim, Greta Sokoloff, Riyan Cheng,
William Johnson, Abraham Palmer, Camron Bryant*
M230. Physical and Emotional Stress Alter Voluntary Morphine Consumption
and Ventral Tegmental Area TORC2 Signaling
Sarah Cooper, Sophia Kaska, Megan Kechner, Michelle MazeiRobison*
M231. Dissociating Appetitive and Consummatory Behavior in Drug Use Prone
and Resistant Animals
Cody Siciliano, Amanda Gabriele, Sara Jones, Mark Ferris*
M232. Dopamine Release and Cocaine Sensitivity Differ Between Striosome
and Matrix Compartments of the Striatum
Armando Salinas, Margaret Davis, David Lovinger*, Yolanda Mateo
197
11/10/15 9:58 AM
M233. Selective Loss of BDNF-TrkB-PLCγ Signaling in Accumbens Shell
Neurons Attenuates Cocaine-Induced Dendritic Spine Formation, but
Increases the Motivation for Cocaine
Ethan Anderson*, Anne Marie Wissman, Daniel Guzman,
Christopher Cowan, David Self
M234. Changes in Cortico-Striatal Neuroplasticity Following Chronic SelfAdministered Methamphetamine
Devesh Mishra, Jose Pena-Bravo, Antonieta Lavin, Carmela
Reichel*
M235. Effects of Maintenance Varenicline on Relapse in Those With and
Without Schizophrenia Spectrum and Bipolar Disorders
Susanne Hoeppner, David Schoenfeld, Corinne Cather, Gladys
Pachas, Anne Eden Evins*
M236. Disrupted Relationship of Conscientiousness to BOLD Activation
During Error Monitoring and Resting State Functional Connectivity in
Cocaine-Dependent and Healthy Control Subjects
Bryon Adinoff*, Jeffrey Spence, Hong Gu, Jake Rice, Katya Rubia,
Yihong Yang, Richard Briggs, Robrina Walker, Elliot Stein
M237. Temporal-Medial Prefrontal Circuitry Identified in Non-Treatment
Seeking Cocaine Users Predicts Relapse in an Independent Cohort of
Treated Cocaine Dependent Individuals
Betty Jo Salmeron*, Xiujuan Geng, Yuzheng Hu, Hong Gu, Bryon
Adinoff, Elliot Stein, Yihong Yang
M238. Persistent Inflammatory Pain Alters Motivated Behavior via
Dysregulation of the Opioid System in the Mesolimbic Pathway
Nicolas Massaly, Adrianne Wilson-Poe, Lucia Hipolito, Sunil Sirohi,
Sandra Comer, Brendan Walker, Michael Bruchas, Jose MoronConcepcion*
M239. Modafinil Reduces Smoked Cocaine Self-Administration in Humans:
Effects Vary as a Function of Cocaine “Priming” and Cocaine Cost
Margaret Haney*, Eric Rubin, Richard Foltin
198
11/10/15 9:58 AM
M240. Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental
Area or the Nucleus Accumbens Attenuates Cocaine Seeking in Rats
Nicole Hernandez, Elizabeth Mietlicki-Baase, John Maurer, Duncan
Van Nest, Matthew Hayes, Heath Schmidt*
M241. N-Acetylcysteine in the Treatment of Alcohol Dependence
Gihyun Yoon*, Suck Won Kim, Joseph Westermeyer
M242. The Next Generation: Passive Exposure to Personal Vaporizer Use
Evokes Combustible Cigarette Desire and Urge in Smokers
Andrea King*, Lia Smith, Patrick McNamara, Caroline Volgman,
Ifeoma Echeazu, Alicia Matthews, Dingcai Cao
M243. Riluzole Impairs Reinstatement to Cocaine Seeking
Marian T. Sepulveda-Orengo, Alyson Auriemma, Kati L. Healey,
Jennifer A. Rojas, Kathryn J. Reissner*
M244. A Double-Blind, Active- and Placebo-Controlled Evaluation of the
Neuropsychiatric Safety and Efficacy of Varenicline and Bupropion
for Smoking Cessation in Subjects With (Pre-Existing) Psychiatric
Disorders: An Objective Blinded Analysis
Charles Wilcox*, Nader Oskooilar, Kimberly Guevarra, My-Linh
Tong, Daniel Grosz, Judy Morrissey, Mellissa Henry, Don De
Francisco
M245. KCa2 Channel Inhibition in the Infralimbic Cortex is Necessary for
mGluR5-Dependent Enhancement of Synaptic Plasticity and Extinction
of Alcohol-Seeking Behavior
Patrick Mulholland*, Reginald Cannady, Justin McGonigal, John
Woodward, Justin Gass
M246. Differential Effects of Recent vs. Past Trauma and Stress on Mood,
Social Support, Binge Alcohol Intake, Emotional Eating and BMI, and
on Neural Responses to Acute Stress
Gretchen Hermes, Dongju Seo, Marc Potenza, Kwang-ik Hong,
Rajita Sinha*
199
11/10/15 9:58 AM
M247. Estimated Risk of Cannabis Dependence Soon After Onset Among
Cannabis Only Users: Possible Influence of Tobacco and Alcohol
Catalina Lopez-Quintero*, James Anthony
M248. Cocaine Cue-Induced Striatal Dopamine Release in Non-Dependent
Cocaine Users
Sylvia Cox, Yvonne Yau, Kevin Larcher, France Durand, Theo
Kolivakis, Scott Delaney, Alain Dagher, Chawki Benkelfat, Marco
Leyton*
M249. Nicotine Withdrawal Alters Neural Responses to Psychosocial Stress
Rebecca Ashare*, Caryn Lerman, Wen Cao, Mary Falcone, Leah
Bernardo, Kosha Ruparel, Ryan Hopson, Ruben Gur, James
Loughead
M250. Discriminative Stimulus Effects of Drug Mixtures: Studies With
Cocaine, MDPV, and Caffeine
Gregory Collins*, Kenner Rice, Charles France
M251. Experimental Conditions Facilitating Escalation of Ethanol
Consumption in Male and Female C57BL/6J Mice
Frank Hall*, Omar Issa, Dankesh Joshi, Dawn Muskiewicz, Yasir
Saber, Michael Vacco
M252. Risk-Preferring Rats Make Worse Decisions and Show Increased
Incubation of Craving After Cocaine Self-Administration
Jacqueline-Marie Ferland, Michael Barrus, Catharine Winstanley*
M253. Moderators of Varenicline Treatment Effects in a Double-Blind,
Placebo-Controlled Trial for Alcohol Dependence
Raye Litten*, Megan Ryan, Joanne Fertig, Daniel Falk
M254. Sustained Opioid Antagonism Increases Stratal Sensitivity to Baby
Schema in Opioid Dependent Patients
An-Li Wang*, Steve Lowen, Igor Elman, Zhenhao Shi, Alexander
Bouril, Anna Rose Childress, Charles O’Brien, Ruben Gur, Daniel
Langleben
200
11/10/15 9:58 AM
M255. Paradoxical Effects of Glucocorticoid Receptor Antagonism in the
Basolateral Amygdala on Drug Context-Induced Relapse to Cocaine
Seeking
Rita Fuchs*, Sierra Stringfield, Amy Arguello, Jessica
Higginbotham, Rong Wang
M256. Impact of Chronic Ethanol Self-Administration on Kappa Opioid
Receptor Regulation of Dopamine Signaling in Nonhuman Primates
Cody Siciliano*, Erin Calipari, Steven Fordahl, James Melchior,
Jordan Yorgason, Yolanda Mateo, Christa Helms, David Lovinger,
Kathleen Grant, Sara Jones
M257. Opioid Withdrawal During Adolescence Alters Brain Glucose
Metabolism Sex-Specifically
Giovanni C. Santoro, Joseph Carrion, Jennifer L. Veith, Crystal
Vilchez, Stephen L. Dewey*
M258. Clonidine Increases the Likelihood That Abstinence can Withstand
Leisure Time in Buprenorphine-Maintained Outpatients
Kenzie Preston*, William Kowalczyk, Karran Phillips, Michelle
Jobes, Melody Furnari, Udi Ghitza, David Epstein
M259. Genetic Variation of the GABA(B) Receptor in Individuals With Alcohol
Use Disorder and Association With Smoking Measures
Mehdi Farokhnia*, Melanie L. Schwandt, Colin A. Hodgkinson,
Lorenzo Leggio
M260. Poor Inhibitory Control Predicts Sensitivity to Amphetamine Reward
Jessica Weafer*, K. Luan Phan, Harriet de Wit
M261. Evaluation of Clinically Efficacious Opioid Analgesics for
Biased Agonism and Correlations to Respiratory Suppression and
Antinociception
Cullen Schmid*, Laura Bohn
201
11/10/15 9:58 AM
M262. Deficits in Striatal Dopamine Release in Cannabis Dependence
Elsmarieke van de Giessen, Jodi Weinstein*, Clifford Cassidy,
Margaret Haney, Zhengchao Dong, Rassil Ghazzaoui, Najate Ojeil,
Lawrence Kegeles, Xiaoyan Xu, Nehal Vadhan, Nora Volkow, Mark
Slifstein, Anissa Abi-Dargham
M263. Towards Developing Procedurally Facile Murine Models of
Methamphetamine-Alcohol Co-Abuse
Karen Szumlinski*, Elissa Fultz, Courtney Hudson, Rianne
Campbell, Tod Kippin
202
11/10/15 9:58 AM
Notes
203
11/10/15 9:58 AM
Notes
204
11/10/15 9:58 AM
Poster Session II – Tuesday, December 8, 2015
Illness
Charles R. Harman*
T0.
T1.
Clinical Staging With the Global Deterioration Scale (GDS) Shows
a Remarkably Uniform Pattern of Temporal Change Over 2 Years in
Healthy Older Persons With Subjective Cognitive Impairment (SCI) in
Accord With Prior Estimates and Observations Indicating a Stage of 15
Years Duration
Barry Reisberg*, Carol Torossian, Francoise Guillo-Ben Arous,
Isabel Monteiro, Melanie Shulman, Ricardo Osorio, Khurram
Janjua, Umang Shah, Romi Shah, Maria Cuartero-Toledo, Amandeep
Bhandal, Tanzeel Shah, Sandra Veigne, Jinfeng Xu
T2.
Cognitive Aging and the Anterior Cingulate: Amyloid and Vascular Risk
Factors
Jose V. Pardo*, Joel T. Lee
T3.
Sex-Dependent Modulation of Age-Related Cognitive Decline by the
L-Type Calcium Channel Gene CACNA1C (Cav1.2)
Panos Zanos*, Shambhu Bhat, Chantelle Terrillion, Robert Smith,
Leonardo Tonelli, Todd Gould
T4.
Tryptophan 2,3-Dioxygenase Gene Prolongs Preimaginal Development
in Vermilion Drosophila Melanogaster Mutants: Implications for AgingAssociated Neurodegenerative Disorders and Aging
Gregory Oxenkrug*, Valeriya Navrotskaya, Paul Summergrad
205
11/10/15 9:58 AM
Poster Session II—Tuesday
T5.
Anxiety Disorders Underlie the Familial Transmission of Suicide
Attempts
Elizabeth Ballard*, Lihong Cui, Rodrigo Machado-Vieira, Carlos
Zarate, Kathleen Merikangas
T6.
Sexually Divergent Expression of Active and Passive Conditioned Fear
Responses
Tina Gruene, Katelyn Flick, Alexis Stefano, Stephen Shea, Rebecca
Shansky*
T7.
Genetic Predictors of Dysmaturation of the Brain’s Intrinsic Network
Architecture: Relation to ADHD and Attention Dysfunction
Chandra Sripada*, Yu Fang, Srijan Sen, Michael Angstadt, Daniel
Kessler
T8.
Integrative Systems Analysis Associates Blood Glucocorticoid Receptor
Dependent Immune Response With PTSD Diagnosis and Treatment
Response
Nikolaos Daskalakis*, Hagit Cohen, Rasha Hammamieh, Janine
Flory, Marti Jett, Charles Marmar, Joseph Buxbaum, Bin Zhang,
Rachel Yehuda
T9.
Methylphenidate Decreases Anxiety-Induced Impairment of Working
Memory Performance in Healthy Subjects
Monique Ernst*, Andrew Davis, Christian Grillon
T10. DICER1 and MicroRNA Regulation in Post-Traumatic Stress Disorder
Aliza Wingo*, Lynn Almli, Jennifer Stevens, Torsten Klengel,
Monica Uddin, Yujing Li, Angela Bustamante, Adriana Lori,
Nastassja Koen, Dan Stein, Allison Aiello, Alicia Smith, Derek
Wildman, Sandro Galea, Karestan Koenen, Bekh Bradley, Elisabeth
Binder, Greg Gibson, Peng Jin, Kerry Ressler
T11. Androgen Regulation of Tyrosine Hydroxylase (TH) and Steroid
Receptors in the Noradrenergic Locus Coeruleus (NE LC) of Male
Macaques
Yelena Belikova, Kenny Phu, Judy Cameron*, Cynthia Bethea
206
11/10/15 9:58 AM
T12. Neural Mechanisms of Psychotherapy for PTSD: Emotional Reactivity
and Regulation
Gregory Fonzo*, Madeleine Goodkind, Desmond Oathes, Yevgeniya
Zaiko, Meredith Harvey, Kathy Peng, Elizabeth Weiss, Allison
Thompson, Sanno Zack, Bruce Arnow, Barbara Rothbaum, Amit
Etkin
T13. Acute Methylphenidate Improves Performance on a Change Detection
Task: A Double-Blind Randomized Controlled Trial in Healthy Males
Jonathon Howlett*, He Huang, Murray Stein, Martin Paulus
T14. A Cardiorespiratory Non-Chemosensory Interoceptive Pathway to Panic
Anxiety Independent of the Amgydala
Sahib Khalsa*, Justin Feinstein, Wei Li, Jamie Feusner, Ralph
Adolphs, Rene Hurlemann
T15. Heart Rate Variability Predicts Vulnerability for Posttraumatic Stress
Disorder in Active-Duty Marines
Arpi Minassian, Adam Maihofer, Dewleen Baker, Caroline
Nievergelt, Mark Geyer, Victoria Risbrough*
T16. Deconstructing Ventral Hippocampal Control of Anxiety-Related
Behavior and Learned Fear
Jessica Jimenez*, Alexander Goldberg, Gokhan Ordek, Stephanie
Pena, Katy Su, Rene Hen, Mazen Kheirbek
T17. Attention Bias Modification Alters Amygdala-Cortical Functional
Connectivity
Jennifer C. Britton*, Travis C. Evans, Nathan A. Fox, Daniel S. Pine,
Yair Bar-Haim
T18. Increased Within-Network and Cross-Network Functional Connectivity
in Returning Veterans With Posttraumatic Stress Disorder
Israel Liberzon, Rebecca Sripada, Joseph Heffernan, Sean Ma,
Sheila Rauch*, - PROGrESS Study Team
207
11/10/15 9:58 AM
T19. Dentate Gyrus Controls Extinction of Contextual Fear Memory
Brian Bernier, Adam Ayoub, Boris Zemelman, Michael Drew*
T20. PACAP Effect on Fertility in Female Mice is Relayed Through Leptin
Receptor Expressing Neurons of the Ventral Premammillary Nucleus
and Central Ventromedial Nucleus of the Hypothalamus
Rachel Ross*, Caroline Maguire, Anne Verstegen, Kong Dong,
Ursula Kaiser, Bradford Lowell, Navarro Victor
T21. Adolescent Caffeine Consumption Enhances Anxiety-Related Behavior
and Disrupts Neuroendocrine Signaling
Casey O’Neill, Ryan Newsom, Jacob Stafford, Talia Scott, Solana
Archuleta, Sophia Levis, Robert Spencer, Serge Campeau, Ryan
Bachtell*
T22. Fear Conditioning and Extinction in Pediatric Obsessive Compulsive
Disorder
Daniel A. Geller*, Joseph F. McGuire, Scott P. Orr, Brent J. Small,
Angelina F. Gomez, Tanya Murphy, Sabine Wilhelm, Daniel Pine,
Eric A. Storch
T23. Post-Traumatic Stress Avoidance is Attenuated by Corticosterone and
Associated With Brain Levels of Steroid Receptor Co-Activator-1 in
Rats
Annie Whitaker*, Scott Edwards, Nicholas Gilpin
T24. Psychostimulant-Induced Modulation of Prefrontal Cortical Activity,
Early Sensory Signal Processing, and Behavioral Performance in
Visually Guided Sustained Attention and Signal Detection Tasks
Barry Waterhouse*, Brian Clark, Rachel Navarra, Luke Mitchell,
Kara Agster
T25. Brain Structure Changes in a 16p11.2 Deletion Mouse Model
Thomas Nickl-Jockschat*, Vinod Kumar Jangir, Nicola Grissom,
Sarah McKee, Hannah Schoch, Nicole Bowman, Robbert Havekes,
Manoj Kumar, Stephen Pickup, Harish Poptani, Teresa Reyes, Ted
Abel
208
11/10/15 9:58 AM
T26. The Brain-Derived Neurotrophic Factor Val66Met Polymorphism is
Associated With Altered Amygdala-Cortical Structural Covariance in
Adolescence
Anne Wheeler*, Daniel Felsky, Joseph Viviano, Arash Nazeri, Jason
Lerch, Mallar Chakravarty, Aristotle Voineskos
T27. Cortical Inhibitory Deficits and Suicidality in Children and Adolescents
Charles Lewis*, Paul Nakonezny, Stephanie Ameis, Jennifer Vande
Voort, Mustafa Husain, Graham Emslie, Zafiris Daskalakis, Paul
Croarkin
T28. Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Reveals
Altered Stress Activation of a Corticolimbic Circuit in Early Adolescent
Rats Exposed to Postnatal Stress
Heather Brenhouse*, Amanda Stroiney, Kelsey Moore, Craig Ferris
T29. Preliminary Evidence for Computer-Based Training Targeting Hostile
Interpretation Bias as a Treatment for DMDD
Joel Stoddard*, Banafsheh Sharif-Askary, Elizabeth Harkins,
Heather Frank, Melissa Brotman, Ian Penton-Voak, Keren Maoz,
Yair Bar-Haim, Marcus Munafo, Daniel Pine, Ellen Leibenluft
T30.Withdrawn
T31. Cognitive Effects of Genetically-Imposed, Non-Vesicular Dopamine
Release: Evidence of Impulsivity and Altered Reinforcement in the DAT
Val559 Mouse
Gwynne Davis, Adele Stewart, Raaj Gowrishankar, Maureen Hahn,
Randy Blakely*
209
11/10/15 9:58 AM
T32. Common and Distinct White Matter Markers in Children With AttentionDeficit/Hyperactivity Disorder, Obsessive Compulsive Disorder and
Autism Spectrum Disorder
Stephanie Ameis*, Jason Lerch, Margot Taylor, Wayne Lee, Joseph
Viviano, Jon Pipitone, Arash Nazeri, Paul Croarkin, Jessica Brian,
Jennifer Crosbie, Aristotle Voineskos, Noam Soreni, Russell
Schachar, Peter Szatmari, Paul Arnold, Evdokia Anagnostou
T33. Male-Specific Reward Learning Deficits in a Mouse Model of Autism
Nicola Grissom*, Sarah McKee, Hannah Schoch, Nicole Bowman,
Robbert Havekes, Thomas Nickl-Jockschat, Teresa Reyes, Ted Abel
T34. State Matters? Intrinsic Brain Function in Children With Autism Awake
and Asleep
Adriana Di Martino*, Krishna Somandepalli, Yihong Zhao, Hallie
Brown, Eva Petkova, Francisco Castellanos, Michael Milham
T35. Identifying Neural Targets of Antidepressant Treatment in Adolescent
Depression
Kathryn Cullen*, Bonnie Klimes-Dougan, Bryon Mueller, Melinda
Westlund, Jazmin Camchong, Dung Vu Hanh Pham, Kelvin Lim
T36. Atypical Neuroanatomy and Intrinsic Functional Connectivity as an
Intermediate Imaging Phenotype for Autism Spectrum Disorder
Susan Shur-Fen Gau*, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, DeMaw Chuang
T37. Changes in Clinical Severity, Social and Cognitive Abilities of Ten
Patients With Rett Syndrome Treated With IGF-1 in an Open Label Trial
Giorgio Pini, Adam Dyer, Niall Mortimer, Daniela Tropea*
T38.Withdrawn
T39. Oxidative Damage and Antioxidant Defenses in Healthy Adolescents
With a History of Childhood Abuse and Neglect
Rodrigo Grassi-Oliveira*, Carine Hartmann do Prado, Andrea
Wieck, Aline Zaparte, Ledo Daruy Filho, Maurilio da Silva Morrone,
José C. Moreira, Moisés Evandro Bauer
210
11/10/15 9:58 AM
T40. Prenatal Stress Alters Intrauterine Microbiome and Contributes to Adult
Female Behavioral Changes
Tamar Gur*, Lena Shay, Aditi Vadodkar, Sydney Fisher, Michael
Bailey
T41. Progressive Abnormalities of Structural Brain Maturation in Youth With
Psychosis-Spectrum Symptoms
Theodore Satterthwaite, Daniel Wolf*, Simon Vandekar, Monica
Calkins, Tianhao Zhang, Guray Erus, Kosha Ruparel, David Roalf,
Tyler Moore, Russell Shinohara, Christos Davatzikos, Ruben Gur,
Raquel Gur
T42. Targeting PDE4 Isoforms for Alcoholism and Alzheimer’s Disease: An
Implication in Alcohol-Related Dementia?
Han-Ting Zhang*, Qiang Wu, Chuang Wang, Rolf Hansen, Youming Jiang, Ying Xu, James O’Donnell
T43. Alterations of GABAergic Inhibition in Mild Cognitive Impairment and
Alzheimer’s Disease
Agenor Limon*, David Baglietto-Vargas, Vitaly Vasilesvo, David
Cribbs, Adolfo Sequeira
T44. Local Changes in Sleep EEG Activity in Obstructive Sleep Apnea: Link
to Alzheimer’s Disease?
Ruth Benca*, Brady Riedner, Stephanie Jones, Giulio Tononi
T45. Familiality of Sensorimotor Alterations in Autism Spectrum Disorder
Matthew Mosconi*, Lauren Schmitt, Stormi White, Kaitlin Conroy,
John Sweeney
T46. Targeting the Reward Circuit Using DBS for Binge Eating in Rats: No
One Site Fits All
Wilder Doucette*, Jibran Khokhar, Nicholas Deveau, Amanda
Simon, Alan Green
211
11/10/15 9:58 AM
T47. Fear of Food in Anorexia Nervosa: Harm Avoidance is Linked to
Diminished Neural Response to Taste Reward
Alice Ely*, Amanda Bischoff-Grethe, Christina Wierenga, A. James
Melrose, Ursula Bailer, Walter Kaye
T48. Substrate-Dependent Postprandial Oxylipin Responses Revealed
Evidence of Nutrient-Gene Interaction in Anorexia Nervosa
Jun Yang, Bruce D. Hammock, Katherine Halmi, Blake Woodside,
Bruce German, Nicholas Schork, Ursula F. Bailer, Walter Kaye,
Christophe Morisseau, Pei-an Betty Shih*
T49. Extended Intermittent Access to Palatable Food Decreases Hippocampal
Neurogenesis and Impairs Hippocampal Function: Effects of Memantine
Antonio Ferragud, Clara Velazquez-Sanchez, Valentina Sabino,
Pietro Cottone*
T50. A Longitudinal Study of Addiction-Like Responses to Food and Alcohol
Consumption Among Individuals Undergoing Weight Loss Surgery
Susan Murray, Samuel Tweardy, Allan Geliebter, Nicole Avena*
T51. Flexible Decision-Making as a Behavioral Biomarker of Cocaine
Addiction in Rats
Stephanie Groman*, Nathaniel Smith, Lihui Chen, Katherine Rich,
Daeyeol Lee, Jane Taylor
T52. Transcriptional Correlates of Aggressiveness in Post-Mortem Brain
Tissue From Suicide Completers
Giovanna Punzi*, Gianluca Ursini, Giovanna Viscanti, Joo Heon
Shin, Tiziana Quarto, Roberto Catanesi, Giuseppe Blasi, Thomas M.
Hyde, Joel E. Kleinman, Alessandro Bertolino, Daniel R. Weinberger
T53. Biological and Behavioral Dissection of the Role of the Serotonin 1B
Receptor in Impulsivity
Katherine Nautiyal*, Shuai Wang, Melanie Wall, Susanne Ahmari,
Peter Balsam, Carlos Blanco, Rene Hen
212
11/10/15 9:58 AM
T54. Brain Activity and Transcriptional Programs in Frontal Lobe and
Hippocampus: Uncoupling and Recoupling Following Anesthesia
Matthew Sapio*, Andrew Mannes, Michael Iadarola
T55. Genetic and Optogenetic Strategies for Probing the Complex Output
Pathways of the Lateral Habenula
Eric Turner*, Yun-Wei Hsu, Lely Quina
T56. The Complications Associated With Treating Depression and Traumatic
Brain Injury: A Case Report of a Suicide Attempt in a 26 Year Old Male
Samantha Saltz*, Gabrielle Hodgins, Arunditi Xantus, D. Jeffrey
Newport, Charles Nemeroff
T57. The Ankyrin 3 Bipolar Disorder Risk Gene Regulates Neuronal
Cytoskeleton Dynamics
Klaudio Gjeluci, Jacob Garza, Francisca Meyer, Vivian Eijsink,
Gerard Martens, Geert Poelmans, Tracey Petryshen*
T58. The Stress-Antidepressant-Diet (SAD) Paradigm and Weight Gain
Suhyun Lee, Martin Lewis, Claudio A Mastronardi, Rachel Li, Paul
Smith, Julio Licinio, Ma-Li Wong*
T59. Neural Correlates of Attention Bias in Irritability and Anxiety
Melissa Brotman*, Wan-Ling Tseng, Jillian Wiggins, Katharina
Kircanski, Lauren White, Heather Frank, Daniel Pine, Ellen
Leibenluft
T60. Sex Differences in Nucleus Accumbens Transcriptome Profiles
Associated With Susceptibility vs. Resilience to Sub-Chronic Variable
Stress
Georgia Hodes*, Madeline Pfau, Immanuel Purushothaman,
Francisca Ahn, Sam Golden, Daniel Christoffel, Hossein Aleyasin,
Meghan Flanigan, Zachary Lorsch, Jian Feng, Gustavo Turecki,
Rachel Neve, Li Shen, Eric Nestler, Scott Russo
213
11/10/15 9:58 AM
T61. Novel Decynium 22 Analogs are Potent and Selective Inhibitors of
Organic Cation Transporter-3
Rheaclare Fraser-Spears*, W. Anthony Owens, Naomi Wyatt, Anwen
M. Krause-Heuer, Ivan Greguric, Paul D. Callaghan, Benjamin H.
Fraser, Wouter Koek, Lynette Daws
T62. Baseline Differences in Two Depressed Populations: Major Depression
With Mixed Features vs. Bipolar I Depression
Keming Gao, Joseph Calabrese*, Andrei Pikalov, Joyce Tsai, Antony
Loebel
T63. Inflammasome Signalling Affects Anxiety- and Depressive-Like
Behaviors and Gut Microbiome Composition
Antonio Inserra, Martin Lewis, Claudio Mastronardi, Geraint
Rogers, Lex Leong, Jocelyn Choo, Ma-Li Wong, Julio Licinio*
T64. Epigenetic SLC1A2 Promoter Hypomethylation in Bipolar Disorder
With Comorbid Addiction
Marin Veldic*, YuBin Choi, Jennifer Ayers-Ringler, Yun-Fang Jia,
Jennifer Geske, Joanna Biernacka, Susan McElroy, Caren Blacker,
Nicoli Carneiro, Mark Frye, Du-Sup Choi
T65. The Role of Extracellular Signal-Regulated Kinases in the
Antidepressant-Like Effects of Scopolamine
James Shoblock*, Natalie Welty, Guang Chen
T66. Effects of Gonadal Steroids on Mood and Emotion Processing in Women
With a History of Postpartum Depression
Crystal Schiller*, Aysenil Belger, Joshua Bizzell, Sarah Johnson,
Peter Schmidt, Gabriel Dichter, David Rubinow
T67. CRH Acts Anxiolytic by Modulating Dopamine Release Through a
Subset of GABAergic Long-Range Projection Neurons
Nina Dedic*, Claudia Kuehne, Karina Gomes, Elmira
Anderzhanova, Jakob Hartmann, Bianca Schmid, Adam Kolarz,
Annette M. Vogl, Carsten T. Wotjak, Valery Grinevich, Elisabeth
Binder, Alon Chen, Mathias V. Schmidt, Wolfgang Wurst, Damian
Refojo, Jan M. Deussing
214
11/10/15 9:58 AM
T68. A2 Noradrenergic Neurons Regulate Forced Swim Test Immobility
Hyungwoo Nam, Ilan Kerman*
T69. Functional Connectivity of Striatum and SSRI Treatment in Major
Depressive Disorder
Go Okada*, Yasumasa Okamoto, Masahiro Takamura, Shigeru Toki,
Tetsuya Yamamoto, Shigeto Yamawaki
T70. Antidepressant Onset of Scopolamine in a Mouse Model
Marcia Ramaker*, William Katzka, Summer Thompson, Stephanie
Dulawa
T71. Affective Processing Bias in Unaffected Siblings of Bipolar Disorder
Patients
M. Mercedes Perez-Rodriguez*, Armando Cuesta-Diaz, Manuela
Russo, Elizabeth Ramjas, Anil Malhotra, Katherine Burdick
T72. Simplifying Acute Tryptophan Depletion (ATD): A New Two Amino
Acid Formula Decreases Tryptophan Influx Across the Blood-Brain
Barrier
Maike Linden, Katrin Helmbold, Janina Kempf, Shabnam Sippas,
Christian Peter Filss, Karl-Josef Langen, Albrecht Eisert, Florian
Daniel Zepf*
T73. Lateral Habenula and Infralimbic Prefrontal Cortex Differentially
Regulate Ventral Tegmental Area Dopamine Neurons: Relevance to
Depression
Jared Moreines*, Zoe Owrutsky, Anthony Grace
T74. Ketamine’s Antidepressant Efficacy is Not Correlated With Baseline
Subcortical Volumes in a Major Depressive Disorder Replication Sample
Mark Niciu*, Nicolas Iadarola, David Luckenbaugh, Dipavo
Banerjee, Erica Richards, Elizabeth Ballard, Nancy Brutsche,
Francis McMahon, Rodrigo Machado-Vieira, Allison Nugent, Carlos
Zarate
T75. Exploring Intrinsic Topologies of the Human Connectome
Olusola Ajilore*, Giorgio Conte, Allen Ye, Angus Forbes, Alex Leow
215
11/10/15 9:58 AM
T76. Treatment of Bipolar Depression With Minocycline and/or Aspirin: An
Adaptive, Double-Blind, Randomized, Placebo-Controlled Clinical Trial
(NCT01429272)
Jonathan Savitz, Kent Teague, Brent Wurfel, Matt Meyer, Matt
Macaluso, Douglas Drevets, William Yates, Ondria Gleason, Wayne
Drevets, Sheldon Preskorn*
T77. Expanded Safety and Feasibility Data for a New Method of Performing
Electroconvulsive Therapy (ECT). Focal Electrically Administered
Seizure Therapy (FEAST)
Gregory Sahlem*, E. Baron Short, Suzanne Kerns, Jon Snipes,
William DeVries, James B. Fox, Carol Burns, Matthew Schmidt,
Ziad H. Nahas, Mark S. George, Harold A. Sackeim
T78. Dysregulated Luteal Phase Startle Response in Premenstrual Dysphoric
Disorder is Corrected by Luteal Sertraline Treatment
Liisa Hantsoo*, Christian Grillon, C. Neill Epperson
T79. The National Pregnancy Registry for Atypical Antipsychotics: Effects of
Fetal Exposure on Risk for Major Malformations
Lee Cohen*, Adele Viguera, Marlene Freeman, Alexandra Sosinsky,
Danna Moustafa, Sonia Hernández-Díaz
T80. Analysis of 23andMe Antidepressant and Efficacy Survey Data: Genome
Wide Association Analyses and Genetic Heritability and Correlation
Estimates
Qingqin Li*, Chao Tian, Guy Seabrook, Jeffrey Nye, Vaibhav
Narayan
T81. Role of Ventral Hippocampal ΔFosB in Social Defeat Responses and
Antidepressant Action
Claire Manning, Andrew Eagle, Paula Gajewski, Michelle MazeiRobison, Alfred Robison*
216
11/10/15 9:58 AM
T82. Results of a Double-Blind Placebo-Controlled Study of the
Antidepressant Effects of the mGlu2 Negative Allosteric Modulator
RG1578
Daniel Umbricht*, Markus Niggli, Patricia Sanwald-Ducray, Denis
Deptula, Rema Moore, Waltraud Grünbauer, Lauren Boak, Silvia
Gatti, Paulo Fontoura, Maurizio Fava
T83. Major Depressive Disorder Increases the Risk for Diabetes by Impairing
Insulin Sensitivity
Li Li*, Richard Shelton, Rachel Chassan
T84. Cortisol Response to Dex/CRH Test as Predictor of Future Mood/
Anxiety Symptoms
Samuel Ridout*, Haruka Minami, Audrey Tyrka, Lawrence Price,
Linda Carpenter
T85. A “Multiple-Hit” Model of Affective Disorders in Rats Selectively Bred
for Differences in Emotional Reactivity: A Novel Animal Model of
Treatment-Resistant Depression
Cigdem Aydin*, Karla Frohmader, Adriana Medina, Peter Blandino,
Stanley Watson, Huda Akil
T86. Cortisol Administration Inhibits Sadness-Related Subgenual Cingulate
Activity in Depression
Keith Sudheimer*, Erin Heinemeyer, Ruth O’Hara, Dalton Duvio,
Alan Schatzberg
T87. Biomarkers of Cognitive Decline in Elderly Depressives
Nunzio Pomara*, Davide Bruno, Adam Ciarleglio, Adam
Constantine, Chelsea Reichert, Eva Petkova, Henrik Zetterberg, Kaj
Blennow
T88. Repeated Brexpiprazole Administration Alters the Activity of
Monoamine System: An in Vivo Electrophysiological Characterization
Chris A. Oosterhof, Mostafa El Mansari, Pierre Blier*
217
11/10/15 9:58 AM
T89. Reinforcement Learning-Based Analysis of a Decision Making Paradigm
Reveals Independent Influence of Distress and Trait Sensation-Seeking
Henry Chase*, Tsafrir Greenberg, Haris Aslam, Richelle Stiffler,
Jeanette Lockovich, Simona Graur, Genna Bebko, Mary Phillips
T90. Basolateral Amygdala Connectivity in Male and Female Veterans With
Psychiatric Disorders
Erin McGlade*, Jadwiga Rogowska, Deborah Yurgelun-Todd
T91. Pharmacokinetic Profiles of Ketamine Dosing Regimens Used in
Preclinical Studies of Its Antidepressant-Like Action
William Eckert, James Shoblock, James McDuffie, Scott Brian,
Michael Letavic, Xiaohui Jiang, Peter Zannikos, Jaskaran Singh,
Guang Chen*
T92. Lurasidone for Major Depressive Disorder With Mixed Features: Effect
of Baseline Depression Severity on Clinical Outcome
J. Craig Nelson*, Trisha Suppes, Joyce Tsai, Yongcai Mao, Andrei
Pikalov, Antony Loebel
T93. Effect of Intranasal Esketamine on Cognitive Functioning in Healthy
Participants: A Randomized, Double-Blind, Placebo-Controlled Study
Randall Morrison*, Maggie Fedgchin, Jaskaran Singh, Peter van der
Ark, Ewa Wajs, Liwen Xi, Peter Zannikos, Wayne Drevets
T94. Repeated Ketamine Exposure During Adolescence Produces Changes in
Reward Sensitivity and Gene Expression in the Nucleus Accumbens in
Adulthood
Eric Parise*, Amy Gancarz, Lyonna Alcantara, Omar Sial, David
Dietz, Carlos Bolanos-Guzman
T95. Developing an Optimized BDNF Measurement for Mood Biomarkers
Maura Furey*, Gallen Triana-Baltzer, Manja Schoene, Paula
Patterson, Randy Slemmon, Hartmuth Kolb
218
11/10/15 9:58 AM
T96. Individualized Prediction of Vulnerability to Bipolar Disorders Using
Structural Neuroimaging Patterns From 307 Individuals and Machine
Learning
Benson Mwangi*, Mon-Ju Wu, Ives Passos, Bo Cao, Giovana ZuntaSoares, Jair Soares
T97. Antidepressant Efficacy in a Rodent Model of Hypoxia-Related
Depression: Do SSRIs Lose Efficacy at Altitude?
Shami Kanekar*, Olena Bogdanova, Paul Olson, Chloe Renshaw,
Kristen D’Anci, Young Hoon Sung, Perry Renshaw
T98. Cognitive Predictors of Sexual Dimorphism in Pediatric Depression
Manpreet Singh*, Lester Mackey, Ian Gotlib, Joachim Hallmayer
T99. Reduced Global Functional Connectivity of the Medial Prefrontal Cortex
in Major Depressive Disorder
James Murrough*, Katherine Collins, Paul Geha, Lynnette Averill,
Kaitlin DeWilde, Edmund Wong, Cheuk Tang, Alan Anticevic, Chadi
Abdallah
T100. Conceptual Convergence: Increased Inflammation is Associated With
Increased Basal Ganglia Glutamate in Patients With Major Depression
Ebrahim Haroon*, Candace Fleischer, Xiangchuan Chen, Jennifer
Felger, Bobbi Woolwine, Xiaoping Hu, Andrew Miller
T101. Resting State Functional Connectivity is a Differential Predictor of
Treatment Outcomes in Major Depressive Disorder
Andrea N. Goldstein-Piekarski*, Brooke Staveland, Mayuresh S.
Korgaonkar, Leanne M. Williams
T102. The Antidepressant-Like Utility of Rho-Kinase Inhibition in Adolescents
is TrkB-Dependent
Lauren Shapiro, Shannon Gourley*
219
11/10/15 9:58 AM
T103. Late Pregnancy Thyroid-Binding Globulin Predicts Perinatal Depression
Cort Pedersen*, Jane Leserman, Nacire Garcia, Melissa Stansbury,
Samantha Meltzer-Brody, Jacqueline Johnson
T104. Abnormal Neurochemistry in the Left Ventrolateral Prefrontal Cortex of
Young Offspring of Bipolar Disorder Parents
Fabiano Nery*, Wade Weber, Michelle Durling, Thomas Blom,
Caleb Adler, Stephen Strakowski, Melissa DelBello
T105. Inflammatory Cytokines are Associated With Decreased Psychomotor
Speed in Female, but not Male, Patients With Major Depression
David Goldsmith*, Ebrahim Haroon, Bobbi Woolwine, Moon Jung,
Evanthia Wommack, Jennifer Felger, Andrew Miller
T106. Intranasal Esketamine in Treatment-Resistant Depression, a Dose
Response Study – Double Blind and Open Label Extension Data
Ella Daly*, Jaskaran Singh, Maggie Fedgchin, Kimberly Cooper,
Pilar Lim, Caroline Melman, Husseini Manji, Luc Van Nueten,
Richard Shelton, Michael Thase, Maha Ahmad, Geert deBruecker,
Wayne Drevets
T107. Neural Functional Changes Resulting From SSRI, ECT, and rTMS
Treatments for Major Depressive Disorder: Meta-Analytic Synthesis and
Comparison
Paul Hamilton*, David Chau, Phoebe Fogelman, Wayne Drevets
T108. Neurocognitive Performance as an Endophenotype for Mood Disorder
Subgroups
Alison K. Merikangas*, Lihong Cui, Victoria Flagg, Jennifer
Glaus, Monica Calkins, Ruben C. Gur, Raquel E. Gur, Kathleen R.
Merikangas
T109. Luzindole Hippocampal Neurogenesis and Modulates DepressiveLike Behaviors via Distinct Actions at the MT1 and MT2 Melatonin
Receptors in C3H/HeN Mice
Margarita L. Dubocovich*, Jiabei Liu
220
11/10/15 9:58 AM
T110. Early Life Stress Modulates the Developmental Trajectory of the
Endocannabinoid System
Matthew Hill*, Lisa Eiland, Cecilia Hillard, Bruce McEwen
T111. Treatment of Cognitive Deficits in Bipolar Disorder With GalantamineER
Dan Iosifescu*, James Murrough, Thilo Deckersbach, Brian
Iacoviello, Andrew Nierenberg
T112. Can Medication Free, Treatment-Resistant, Depressed Patients who
Initially Respond to TMS be Maintained off Medications? A Prospective,
12-Month Multisite Randomized Pilot Study
Linda Carpenter*, Noah Philip, David Dunner, Sheila Dowd, Scott
Aaronson, Mark Demitrack, Sarit Hovav, Philip Janicak, Mark
George
T113. Longitudinal Cognitive Outcomes in Late-Life Depression: Effects of
Achieving Antidepressant Remission
Meghan Riddle, Guy Potter, Douglas McQuoid, David Steffens,
Warren Taylor*
T114. Lurasidone Treatment of Major Depression With Mixed Features: Effect
on Sexual Function
Anita Clayton*, Joyce Tsai, Yongcai Mao, Andrei Pikalov, Antony
Loebel
T115. Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
Signaling on Social Interaction
Rachel Donahue*, Archana Venkataraman, Elysia Ridener, Myles
Donahue, Edward Meloni, William Carlezon
T116. Effect of a Dietary Supplement on Predisposition to Depressed Mood in
Postpartum
Yekta Dowlati*, Arun Ravindran, Zindel Segal, Meir Steiner, Donna
Stewart, Jeffrey Meyer
221
11/10/15 9:58 AM
T117. Patterns of Caudate Connectivity During Cognitive Control During Late
Life Depression and Healthy Aging
Sara Weisenbach*, Julia Rao, Taylor Greif, Dan Fitzgerald, Maura
Wolfe, Jon-Kar Zubieta, Robert Welsh, Scott Langenecker
T118. Increased Susceptibility of Hypogonadal Male Mice to Social Stress is
Mediated by Estradiol
Polymnia Georgiou*, Panos Zanos, Margaret McCarthy, Mary Kay
Lobo, Istvan Merchenthaler, Laszlo Prokai, Todd Gould
T119. Stem Cell Models of Bipolar Disorder
Aislinn Williams*, Cynthia DeLong, Monica Bame, Emily Martinez,
Melvin McInnis, K. Sue O’Shea
T120. PACAP Signaling in the BNST: A Nexus for Stress and Emotion
Kim Lezak*, Erin Roelke, Olivia Harris, Gina Cocchiaro, Galen
Missig, Carolyn Roman, Donna Toufexis, Karen Braas, Victor May,
Sayamwong Hammack
T121. Interoceptive Insula Activity to Food Cues is Negatively Correlated With
Behavioral Ratings of Expected Food Pleasantness in Depressed Patients
With Increased Appetite
W. Kyle Simmons*, Kaiping Burrows, Jason Avery, Kara Kerr,
Casey Mullins, Jerzy Bodurka, Wayne Drevets
T122. Limbic Network Exhibits the Highest Degree of Embeddedness in the
Human Brain Structural Connectome
Allen Ye, Liang Zhan, Sean Conrin, Johnson GadElkarim, Aifeng
Zhang, Shaolin Yang, Jamie Feusner, Anand Kumar, Olusola Ajilore,
Alex Leow*
T123.Withdrawn
T124. Genomic and Brain Transcriptomic Variation of Mouse MicroRNAs
Juho Väänänen, Kalevi Trontti, Katherine Icay, Tessa Sipilä, Dario
Greco, Iiris Hovatta*
T125. Mapping Functional Connectivity Networks in the Individual
Hesheng Liu*, Danhong Wang, Randy Buckner
222
11/10/15 9:58 AM
T126. Raman Spectroscopy for Reagentless Workflow Enhancement to
Monitor Human iPSC Research
Vishwajit Nimgaonkar*, Leonardo D’Aiuto, Peter Dimitrion,
Heather Kirschner, Lora McClain, Aaron Smith, Shona Stewart, Yun
Zhi, Patrick Treado
T127. Missense Mutation in FOLH1 is Associated With Differences in Gene
Expression and Neuroimaging Phenotypes
Kristin Bigos*, Andrew Jaffe, Qiang Chen, Joel Kleinman, Thomas
Hyde, Venkata Mattay, Daniel R. Weinberger
T128. Multimodal Neuroimaging of Visual Plasticity in Healthy Humans
Laura Rowland*, Andrea Wijtenburg, Franchesca Kuhney, Stephanie
Korenic, Sarah Nisonger, Jef West, Frank Gaston, Ana Pocivavsek,
Peter Kochunov, Elliot Hong
T129. Relationship Between the Effects of Nicotine on Subjective State and
Vigilance Task Performance in Healthy Non-Smokers
Megan McComas*, Alexander Harvey, Britta Hahn
T130. Circuit Components and Dynamics of a Putative Top-Down Attentional
Filter
Brian Mathur*, Michael White
T131. Prenatal LPS Exposure Preferentially Increases Kynurenine Pathway
Metabolism in the Fetal Brain
Francesca M. Notarangelo*, Kevin S. Wons, Robert Schwarcz
T132. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the
Autism Risk Gene, CNTNAP2
Ellen Hoffman*, Katherine Turner, Joseph Fernandez, Stephen
Wilson, Jason Rihel, Matthew State, Antonio Giraldez
T133. The National Neuroscience Curriculum Initiative (NNCI): Progress on
Preparing for the Future of Psychiatry
David Ross, Melissa Arbuckle, Jane Eisen, Michael Travis*
223
11/10/15 9:58 AM
T134. The Cooperation of Hemispheres and Consciousness
Oldrich Vinar*
T135. Multi-Tracer Pet Characterization of Pre- and Post -Synaptic
Dopaminergic Systems
Daniel Eisenberg*, Angela Ianni, Catherine Hegarty, Philip Kohn,
Michael Gregory, Jasmin Czarapata, Joseph Masdeu, Karen Berman
T136. Presynaptic Midbrain Dopamine Modulates Adaptive Prediction Error
Signals in Humans
Mbemba Jabbi*, Brett Cropp, Philip Kohn, Tiffany Nash, J.
Shane Kippenhan, Raghav Mattay, Michael D. Gregory, Mathias
Pessiglione, Joseph Masdeu, Daniel P. Eisenberg, Karen F. Berman
T137. Psychological Factors, Hormones, and Brain Activity as Potential
Biomarkers in Predicting Weight Loss Following Bariatric Surgery: A
Pilot Study
Laura Holsen*, Priyanka Moondra, Paul Davidson, Florina
Haimovici, Anne Eden Evins, Jill Goldstein, Luke Stoeckel
T138. The Effects of Chronic Stress and HIV Disease on Hippocampal and
Amygdala Shape Alterations and Verbal Memory Performance
April Thames*, Taylor Kuhn, Daniel Schonfeld, Robert Bilder,
Susan Bookheimer, Charles Hinkin, Philip Sayegh, Zanjbeel
Mahmood
T139. Early Life Stress and Impaired Glycemic Control in Urban African
Americans With Type 2 Diabetes
Marcia McNutt, Dominique Musselman*, David Ziemer, Bridget
Larsen, Angelo Brown, Erica Royster, Lawrence Phillips, Phillip
Harvey
T140. Increased Translocator Protein in the Brains of Active and Recently
Retired NFL Players: A Pilot Study Using [11C]DPA-713 PET-Based
Neuroimaging
Jennifer Coughlin*, Yuchuan Wang, Melin Vranesic, Il Minn,
Nicholas Bienko, Matthew Peters, John Dougherty, Cynthia Munro,
Martin Pomper
224
11/10/15 9:58 AM
T141. Understanding How CSF Tau Concentrations Reveal Alzheimer’s
Disease
Gallen Triana-Baltzer*, Randy Slemmon, Alice Shapiro, Marc
Mercken, Johannes Streffer, Henrik Zetterberg, Kaj Blennow,
Hartmuth Kolb
T142. Examining the Effect of a Pathway-Selective Mutation on
Communication From Thalamus to Cortex in a Mouse Model of Autism
Brian Theyel*, Barry Connors
T143. PET Reveals Interactions of Dopamine and Serotonin Systems in
Subtypes of Tourette’s Syndrome and Obsessive-Compulsive Disorder
Dean Wong*, James Brasic, Hiroto Kuwabara, Yun Zhou, Ayon
Nandi, Anil Mathur, Noble George, Boris Frolov, Harvey Singer,
Anthony Grace, Gerald Nestadt
T144. Decoding Brain Epigenome Maps With Broad H3K4me3 Signals:
Discovering Functional Epigenetic Patterns and Their Dynamics in Gene
Regulatory Networks
Aslihan Dincer*, Bin Zhang, David P. Gavin, Ke Xu, Joel T. Dudley,
Eric E. Schadt, Schahram Akbarian
T145. PRISM II: Effectiveness of Dextromethorphan 20 mg/Quinidine 10 mg
(NUEDEXTA®) for Treatment of Pseudobulbar Affect Secondary to
Dementia, Stroke, or Traumatic Brain Injury: Combined Results of a
Multicenter Open-Label Study
Flora Hammond, Joao Siffert, David Alexander, Andrew J. Cutler,
Stephen D’Amico, Rachelle Doody, Andrea Formella*, Fred Ledon,
William Sauve, Paul Shin, Charles Yonan, Richard Zorowitz
T146. A High Density EEG Study of Shared Attention and Visual Perspective
Taking
Royce Lee*, Jennifer Fanning, Vernon Towle, Sarah Keedy, Emil
Coccaro
T147.Withdrawn
225
11/10/15 9:58 AM
T148. The Computational Role of Hippocampus in Social Dysfunction
Rita Tavares, Temidayo Orederu, Daniela Schiller*
T149. Prefrontal Functional Connectivity and Hostility in First-Episode
Schizophrenia
Deepak Sarpal*, Todd Lencz, Delbert Robinson, Miklos Argyelan,
Philip Szeszko, Katherine Karlsgodt, Juan Gallego, Anil Malhotra
T150. Dopamine D2 Receptors Availability in the Dorsal Caudate and Learning
in Patients With Schizophrenia: A Prospective PET [11C]-Raclopride
Study
Tarek Rajji*, Benoit Mulsant, Shinichiro Nakajima, Fernando
Caravaggio, Takefumi Suzuki, Hiroyuki Uchida, Philip Gerretsen,
Wanna Mar, Bruce Pollock, David Mamo, Ariel Graff
T151. Memantine’s Acute Effects on Neurocognition in Schizophrenia (SZ) as
a Predictor of Neurocognitive Benefits From Compensatory Cognitive
Training (CCT)
Savita Bhakta, Elizabeth Twamley, Gregory Light, Jo Talledo, HsunHua Chou, Bryan Balvaneda, Laura Gaddis, Neal Swerdlow*
T152. N-Methyl-D-Aspartate Receptor (NMDAR)-Based Enhancement of
Auditory Plasticity
Joshua Kantrowitz*, Michael Epstein, Odeta Beggel, Stephanie
Rohrig, Jonathan Lehrfeld, Nadine Revheim, Nayla Scaramello,
Emily Parker, Jacob Reep, Gail Silipo, Daniel Javitt
T153. Altered Ca2+ Channel Function in the Fast-Spiking Interneurons of an
NMDAR Hypofunction Mouse Model for Schizophrenia
Andrew Bohannon, Vivek Jeevakumar, Kazuhito Nakao, John
Hablitz, Kazu Nakazawa*
T154. Self-Assessment of Social Cognitive Functioning in Patients With
Schizophrenia vs. Healthy Controls
Dante Durand*, Amy Pinkham, David Penn, Philip Harvey
226
11/10/15 9:58 AM
T155. Progressive Reduction of Auditory Evoked Gamma in First Episode
Schizophrenia but Not Clinical High Risk Individuals
Naoya Oribe, Yoji Hirano, Shigenobu Kanba, Toshiaki Onitsuka,
Larry Seidman, Raquelle Mesholam-Gately, Kristen Woodberry,
Joanne Wojcik, Martha Shenton, Jill Goldstein, Margaret
Niznikiewicz, Robert McCarley, Kevin Spencer*
T156. Intact Sensitivity to External Performance Feedback in Schizophrenia:
Electrophysiological and Temporal Stability
Katiah Llerena*, Jonathan K. Wynn, Greg H. Proudfit, Michael
Green, William P. Horan
T157. Choline Increases in the Dorsal Anterior Cingulate of Patients With
Psychosis Measured With Magnetic Resonance Spectroscopy
Stefano Marenco*, Christian T. Meyer, Jan Willem van der Veen,
Ryan Kelly, Jun Shen, Daniel R. Weinberger, Jose A. Apud, Karen F.
Berman
T158. Translational Optogenetic Modeling of Spindle Deficit in Schizophrenia
Stephen Thankachan, Fumi Katsuki, James McNally, James
McKenna, Robert Strecker, Ritchie Brown, Robert McCarley*
T159. Genetic Variation in GRM5 is Associated With Cognition, Hippocampal
Volume and Schizophrenia
Natalie Matosin*, Yann Quidé, Ian C. Gould, Nina Teroganova,
Jessica L. Andrews, Kelly A. Newell, Melissa J. Green, Francesca
Fernandez-Enright
T160. Deficiency of Neurogranin, a Susceptibility Gene for Schizophrenia,
Confers Multiple Molecular and Behavioral Phenotypes Related to
Schizophrenia
Tsuyoshi Miyakawa*, Hideo Hagihara, Satoko Hattori, Yoshihiro
Takamiya, Toshiki Kameyama, Yuya Ouchi, Hidehito Inagaki, Hiroki
Kurahashi, Freesia Huang, Kuo-Ping Huang
227
11/10/15 9:58 AM
T161. In Vivo Mapping of Cortical Glutamate in Youth at Clinical High Risk
for Psychosis: a Glutamate Chemical Exchange Saturation Transfer
Study
David Roalf*, Petra Rupert, Megan Quarmley, Hari Hariharan, Ravi
Prakash Reddy Nanga, Mark Elliott, Ravinder Reddy, Paul Moberg,
Raquel Gur, Bruce Turetsky
T162. Cognitive Remediation With Yoga for Patients With Schizophrenia
Triptish Bhatia*, Sati Mazumdar, Joel Wood, Fanyin He, Raquel E.
Gur, Ruben C. Gur, Vishwajit L. Nimgaonkar, Smita N. Deshpande
T163. DNA Sequencing in Multiplex Families With Schizophrenia and
Affective Disorder
Lynn E. DeLisi*, Oliver Homann, Kira Misura, Paul Nelson, Stefan
McDonough
T164. Neurocognitive Profiles and Cognitive Training Effects on Emotionality
and Aggression in Schizophrenia
Anthony Ahmed*, Brielle Marino, Elizabeth Rosenthal, Njideka
Oragunye, Alex Buckner
T165. Transcription Factor MEF2C, Associated With Neuronal Epigenome
Alterations in Schizophrenia, Improves Cognition and Working Memory
Amanda Mitchell*, Behnam Javidfar, Venu Pothula, Daisuke Ibi,
Erica Y. Shen, Cyril J. Peter, Lucy Bicks, Tristan Fehr, Yan Jiang, Iris
Cheung, Rina Davidson, Kristen Brennand, Javier Maseo, Schahram
Akbarian
T166. Conditioning Illusory Percepts: Testing a Predictive Coding Model of
Hallucinations
Albert Powers*, Philip Corlett
T167. Reduced CYFIP1 in iPSC Derived Human Neural Progenitors Results in
Donor Specific Dysregulation of Schizophrenia and Epilepsy Genes
Rebecca Nebel, Dejian Zhao, Erika Pedrosa, Jill Kirschen, Herbert
Lachman, Deyou Zheng, Brett Abrahams*
228
11/10/15 9:58 AM
T168. Evaluating Cannabis Use on Cortical Inhibition Prior To - and Following
28-Day Abstinence Period in Patients With Schizophrenia: Preliminary
Findings From a TMS-EEG Study
Mera S. Barr*, Michelle S. Goodman, Genane Loheswaran, Reza
Zomorrodi, Rachel Rabin, Tarek Rajji, Zafiris Daskalakis, Tony
George
T169. Small Molecule Antagonists of the VPAC2 Receptor as a Novel
Direction for Schizophrenia Therapeutics
Talia Atkin*, Prashant Donthamsetti, Xiaoming Xu, Alison
Rinderspacher, Caitlin Burgdorf, Donald Landry, Maria Karayiorgou,
Shixian Deng, Jonathan Javitch, Joseph Gogos
T170. Long-Term Cariprazine Treatment for the Prevention of Relapse in
Patients With Schizophrenia: Additional Analysis From a Randomized,
Double-Blind, Placebo-Controlled Trial
Suresh Durgam, Willie Earley, Rui Li, Dayong Li, Kaifeng
Lu, István Laszlovszky, John Edwards*, Henry Nasrallah, W.
Fleischhacker
T171. Does the Connection Between Adolescent Cannabis Use and
Schizophrenia Extend Beyond Psychosis? Effects on Alcohol Intake,
Reward Learning and Motivation
Jibran Khokhar*, Travis Todd, Wilder Doucette, David Bucci, Alan
Green
T172. fMRI of Aversive Face Conditioning in Clinical Risk and Schizophrenia
Daniel Wolf*, Megan Quarmley, Joanna Kass, Kosha Ruparel, Bruce
Turetsky, Karthik Prabhakaran, Adam Savitt, Petra Rupert, Warren
Bilker, Mark Elliott, Ruben C. Gur, Raquel E. Gur
T173. Effects of Past Moderate Cannabis Use on Cognition in First Episode
Schizophrenia and Typically Developing Adolescents: A Multimodal
Analysis of Brain Structure and Function
Tyler Lesh, Tara Niendam, Ragland Dan, Cameron Carter*
229
11/10/15 9:58 AM
T174. Association of a Schizophrenia Risk Variant at the DRD2 Locus With
Antipsychotic Treatment Response in First Episode Psychosis
Jianping Zhang*, Delbert Robinson, Juan Gallego, Majnu John, Jin
Yu, Jean Addington, Mauricio Tohen, John Kane, Anil Malhotra,
Todd Lencz
T175. Cognitive Function in Individuals With Psychosis: Moderation by
Adolescent Cannabis Use
Subroto Ghose*, Rebecca Hanna, Alexandra Shalvoy, C. Munro
Cullum, Elena Ivleva, Matcheri Keshavan, Godfrey Pearlson, S.
Kristian Hill, John Sweeney, Carol Tamminga
T176. White Matter Abnormalities Associated With Psychotic-Like
Experiences Predict Later Social Competency in Children and
Adolescents
Pamela DeRosse*, Toshikazu Ikuta, Katherine Karlsgodt, Bart
Peters, Chaya Gopin, Philip Szeszko, Anil Malhotra
T177. Effects of the Antioxidant N-Acetyl Cysteine on Behavioral and
Neurophysiological Deficits Induced by Developmental NMDA-R
Antagonism and Their Relationship to Mitochondrial Dysfunction
Aarron Phensy, Jing Tian, Christopher Driskill, Vivek Jeevakumar,
Samantha Oborny, Heng Du, Sven Kroener*
T178. Stress-Induced Changes in AMPA Receptor RNA Editing Are Reversed
by Clozapine
Evelyn Nwabuisi-Heath, Erbo Dong, Alessandro Guidotti, Monsheel
Sodhi*
T179. HDAC2 but not HDAC1 Transcript Levels are Reduced in the
Postmortem DLPFC From Schizophrenia Patients Compared to NonPsychiatric Controls
Frederick Schroeder*, Ningping Feng, Jacob Hooker, Nora Volkow,
Robert Innis, Barbara Lipska
230
11/10/15 9:58 AM
T180. Cortical D1 Tone Predicts Network Dynamics of Working Memory: A
Simultaneous PET-fMRI Investigation
Joshua Roffman*, Alexandra Tanner, Hamdi Eryilmaz, Noah
Silverstein, New Fei Ho, Adam Nitenson, Douglas Greve, Randy
Buckner, Dara Manoach, Bruce Rosen, Anissa Abi-Dargham, Jacob
Hooker, Ciprian Catana
T181. An Epigenetic Model of Schizophrenia
Olivier Civelli*, Amal Alachkar, Lien Wang, Soomin Lee, Zhiwei
Wang, Geoff Abbott
T182. Serotonergic Hallucinogens Preferentially Activate Subsets of Cortical
Neurons, Interneurons, and Glial Cells in the mPFC, Somatosensory
Cortex, and Claustrum, and Induce Rapid Redistribution of 5-HT2A
Receptor Protein in Neurons
Charles Nichols*, David Martin
T183. The Effects of NMDA Receptor Co-Agonist Availability on Reward
Processing Using a Mouse Model of Anhedonia: Implications for CoMorbid Schizophrenia and Substance Dependence
Matthew Puhl*, Rachel Donahue, Samantha Landino, William
Carlezon, Joseph Coyle
T184. Protein Pathology of NKCC1 (SLC12A2) as a Marker in Chronic
Mental Illness
Rita Marreiros, Philipp Ottis, Svenja Trossbach, Ingrid Prikulis, KaWan Li, Ran Tao, Thomas Hyde, Joel Kleinman, Nicholas Brandon,
William Hennah, August Smit, Carsten Korth*
T185. Clozapine Causes Alterations in Endoplasmic Reticulum Stress
Response Molecules in the Absence of Apparent Weight Gain or GTT/
ITT Disruptions
Consuelo Walss-Bass*, Elena Dyukova, Jahnavi Shriram, Laura
Stertz
231
11/10/15 9:58 AM
T186. Neuropsychological Profile in Adult Schizophrenia Measured With the
CMINDS®
Theo van Erp*, Adrian Preda, Jessica Turner, Shawn Callahan, Vince
Calhoun, Juan Bustillo, Kelvin Lim, Bryon Mueller, Gregory Brown,
Jatin Vaidya, Sarah McEwen, Aysenil Belger, James Voyvodic,
Daniel Mathalon, Dana Nguyen, Judith Ford, Steven Potkin
T187. Relationship Between Response to Aripiprazole Once-Monthly and
Paliperidone Palmitate on Work Readiness and Functioning: A Post-Hoc
Analysis of QUALIFY, a Head-to-Head Study in Schizophrenia
Steven Potkin*, Jean-Yves Loze, Carlos Forray, Ross A. Baker,
Christophe Sapin, Timothy Peters-Strickland, Maud Beillat, AnnaGreta Nylander, Peter Hertel, Simon Nitschky Schmidt, Anna
Eramo, Karina Hansen, Dieter Naber
T188. Divergent Transcription of the BDNF Locus: Relevance for
Schizophrenia
Gianluca Ursini*, Giovanna Punzi, Joo Heon Shin, Kristen Maynard,
Eugenia Radulescu, Andrew Jaffe, Yankai Jia, Venkata S. Mattay,
Joel E. Kleinman, Thomas M. Hyde, Keri Martinowich, Daniel R.
Weinberger
T189. Replication of Patterns in Gray Matter Abnormalities for Targeted Drug
Development in Multi-Site Schizophrenia Datasets
Vince Calhoun*, Cota Navin Gupta, Srinivas Rachkonda, Jiayu
Chen, Veena Patel, Jingyu Liu, Judith Segall, Barbara Franke,
Simon Fischer, Guillen Fernandez, Theo van Erp, Steven Potkin,
Judith Ford, Daniel Mathalon, Sarah McEwen, Hyo Jong Lee,
Bryon Mueller, Douglas Greve, Ole Andreassen, Ingrid Agartz,
Randy Gollub, Scott Sponheim, Stefan Ehrlich, Lei Wang, Godfrey
Pearlson, David Glahn, Emma Sprooten, Andrew Mayer, Julia
Stephen, Jose Canive, Juan Bustillo, Jessica Turner
T190. Do the Therapeutic-Like Effects of Acute Oxytocin Persist With Chronic
Administration?
David Feifel*, Paul Shilling, Gilia Melendez, Amand Srivastava,
Imran Damani, Mohammad Rashid, Win Thuy-uyen Huynh, Justine
Tran
232
11/10/15 9:58 AM
T191. Feedback-Controlled Sleep Spindle Transcranial Alternating Current
Stimulation Reveals the Functional Role of Sleep Spindles in Motor
Memory Consolidation
Caroline Lustenberger, Michael Boyle, Sankar Alagapan, Juliann
Mellin, Bradley Vaughn, Flavio Frohlich*
T192. Estimating Uncertain Dynamic Context in Schizophrenia
Hao Yang Tan*, Claire Kaplan, Debjani Saha, Juan Molina,
Elizabeth Postell, Jose A. Apud, Daniel Weinberger
T193. Recollection and Familiarity of Social Recognition Memory in
Schizophrenia: Performance and Relationship to Functional Outcome
Across the Phase of Illness
Junghee Lee*, Keith H. Nuechterlein, Carrie Bearden, Ty Cannon,
William P. Horan, Robert S. Kern, Barbara J. Knowlton, Kenneth L.
Subotnik, Joseph Ventura, Michael F. Green
T194. Sibling Risk of Schizophrenia Patients in Taiwan: First Large‐Scale
National Population-Based Study From 2001 to 2011
Tung-Ping Su*, Annie Chang, Mu-Hong Chen, Cheng-Ta Li, WeiChen Lin, Pei-Chi Tu, Ya-Mei Pai, Chih-Ming Cheng
T195. Paliperidone Palmitate 3-Month vs. 1-Month Formulation in Patients
With Schizophrenia: A Randomized, Double-Blind, Noninferiority Study
W. Fleischhacker*, Adam Savitz, Haiyan Xu, Srihari Gopal, Isaac
Nuamah, Paulien Ravenstijn, Adam Janik, Alain Schotte, David
Hough
T196. Cognitive Deficit in Schizophrenia: Specific or General?
Karny Gigi, Michael Davidson, Abraham Reichenberg, Mark
Weiser*
T197. Transcriptome Profiling of Layer 3 Parvalbumin Neurons From the
Dorsolateral Prefrontal Cortex of Schizophrenia Subjects
John Enwright*, Dominique Arion, John Corradi, Aiqing He,
Zhiguang Huo, George Tseng, David Lewis
233
11/10/15 9:58 AM
T198. Disruption of Metabolic Coupling to Glutamate Uptake Systems
Contributes to the Pathophysiology of Schizophrenia
Robert McCullumsmith*, Sinead Odonovan, Rosalinda Roberts
T199. The Parvalbumin Interneuron-Enriched microRNA, miR-206, Regulates
Cortical GABAergic Transmission and Schizophrenia-Related Behaviors
in Mice
Mary Heyer*, Masago Ishikawa, Paul Kenny
T200. Heritability of Brain Structure and Glutamate Levels in the Anterior
Cingulate and Left Thalamus Assessed With MR: A Twin Study
Brian Broberg*, Christian Legind, René Mandl, Maria Jensen,
Simon Anhøj, Rikke Hilker, Egill Rostrup, Birte Glenthoj
T201. DNA Methylation of the RalA Binding Protein 1 Gene and Metabolic
Syndrome Risk in Schizohprenia and Bipolar Disorder
Kyle Burghardt*, Vicki Ellingrod
T202. Auditory Mismatch Negativity in Schizophrenia: A Neurodevelopmental
Perspective
Cheryl Corcoran*, Antigona Martinez, Elisa Dias, Anastasia Stoops,
Pejman Sehatpour, Daniel Javitt
T203. Maintenance ECT for Clozapine Resistant Schizophrenia
Georgios Petrides*, Raphael Braga, Chitra Malur, Samuel Bailine,
Nina Schooler, Anil Malhotra, Majnu John, John Kane, Alan
Mendelowitz
T204. Resolving “Deficit” and “Distress” Schizophrenia Subgroups From
Positive and Negative Syndrome Scale Data
Dwight Dickinson*, Danielle Pratt, Jennifer Orel, Evan Giangrande,
Daniel R. Weinberger, Karen Berman
T205. Understanding the Relationship Between Neuroinflammation and
Cognitive Outcomes in First-Episode Psychosis
Amanda Lyall*, Delbert Robinson, Ofer Pasternak, Dominick
Newell, Juan Gallego, Katherine Karlsgodt, Anil Malhotra, Philip
Szeszko, Marek Kubicki
234
11/10/15 9:58 AM
T206. Positive Allosteric Modulators of the Alpha7 Nicotinic Receptor:
Potential Cognition Enhancement Through Potentiation of Cortical
Glutamate and Acetylcholine Release
David M. Bortz, Brian Upton, Jackson Schumacher, Valentina
Valentini, John P. Bruno*
T207. Accumbens Regulation of Prefrontal Glutamate and Dopamine Release
Requires Stimulation of Cortical Alpha7 Nicotinic Receptors
Valentina Valentini*, David M. Bortz, Gian Pietro Serra, Valentina
Perra, David Phenis, Gaetano Di Chiara, John P. Bruno
T208. Preclinical Abuse Potential Assessment of Flibanserin: Effects on
Intracranial Self-Stimulation in Female and Male Rat
Sidney Negus*, Matthew Lazenka, Bruce Blough
T209. EEG as an Information Transfer Device
Todd Zorick*, Jason Smith
T210. Effects of Chronic Adolescent Exposure to Cannabis Smoke on Adult
Behavioral Outcomes
Barry Setlow*, Shannon Wall, Sara Heshmati, Darin Jagnarine,
Abhigyan Ravula, Kailey Simpson, Caitlin Orsini, Marcelo Febo,
Adriaan Bruijnzeel
T211. Impairment of Neuroplasticity by Binge Drinking of Alcohol: A Paired
Associative Stimulation Study
Genane Loheswaran*, Mera S. Barr, Tarek Rajji, Daniel M.
Blumberger, Bernard Le Foll, Zafiris Daskalakis
T212. Role of α5 Subunit Containing Nicotinic Receptors in Modulating
Striatal Dopamine Release and Cue Evoked Learning
Patrick Tierney*, William Howe, Damon Young, Jonathan GarstOrozco, Amie Rossi, Edward Guilmette, Samantha Lyons, Rouba
Kozak
T213. Infralimbic PFC and Nucleus Accumbens Shell Connectivity in the
Regulation of Habitual Reward Seeking
Jacqueline Barker*, Benjamin Goldwasser, L. Judson Chandler
235
11/10/15 9:58 AM
T214. Activation of Accumbal Nitrergic Interneurons and Subsequent Nitric
Oxide Release Underlies Relapse to Cocaine Seeking
Michael Scofield*, Heather Boger, Cassandra Gipson-Reichardt,
Peter Kalivas
T215. Common Grey Matter Reductions Across Addictive Disorders Converge
in the Insula, vmPFC, and Thalamus
Matthew Sutherland*, Michael Riedel, Karina Falcone, Ilan Garcia,
Kevin Garcia, Elliot Stein, Angela Laird
T216. Cognitive Functioning as a Marker of Resting-State Connectivity in
Cocaine Addiction
Anna Zilverstand*, Scott Moeller, Muhammad Parvaz, Rebecca
Preston-Campbell, Pias Malaker, Nelly Alia-Klein, Rita Goldstein
T217. Do We Need to Treat Risk? Attitudes Toward Risk and Ambiguity in
Opioid Addiction
Anna Konova*, Silvia Lopez-Guzman, John Rotrosen, Stephen Ross
T218. A Role for the Dynorphin/Kappa Opioid Receptor System in Binge-Like
Alcohol Consumption in Mice
Rachel Anderson*, Thomas Kash, Howard Becker
T219. White Matter Abnormalities in Individuals With Cocaine Use Disorder
Rafael O’Halloran*, Anna Zilverstand, Nelly Alia-Klein, Rita
Goldstein
T220. Nicotine Enhances Initial Sensitivity and Acute Functional Tolerance to
Alcohol
Joseph Lutz, Timothy O’Neal, Emma Childs*
T221. Changes in mGluR5 Glutamate Receptor Availability Following
Sensitization to D-Amphetamine: A [11C]ABP688 PET Study
Kelly Smart*, Atsuko Nagano-Saito, Michele S. Milella, Paul
Gravel, Jennifer Lissemore, Pedro Rosa-Neto, Salah El Mestikawy,
Marco Leyton, Chawki Benkelfat
236
11/10/15 9:58 AM
T222. Differences Between Treatment and Non-Treatment Seeking Alcoholics:
Do They Matter?
Megan Yardley*, Emily Hartwell, Daniel Roche, Spencer Bujarski,
Lara Ray
T223. NRG3-ErbB4 Signaling Mediates Nicotine–Induced Synaptic Plasticity
in Orbital Frontal Cortex
Luyi Zhou*, Pavel Ortinski, Jill Turner
T224. The Role of µ-Opioid Receptor (OPRM1) Gene A118G Polymorphism
on Cortisol and β-Endorphin Response to Alcohol
Joshua Gowin*, Marion Coe, Melanie Schwandt, Jenica Tapocik,
Hui Sun, Erick Singley, Robert Eskay, John Umhau, Markus Heilig,
Vijay Ramchandani
T225. Morphine-Associated Contextual Cues Induce Structural Plasticity on
CA1 Pyramidal Neurons in the Hippocampus
Amanda Fakira*, Nicolas Massaly, Alexandra Berman, Omid
Cohensedgh, Jose Moron-Concepcion
T226. Intranasal Oxytocin Reduces Cue-Induced Craving in Cigarette Smokers
Melissa Miller*, Anya Bershad, Andrea King, Royce Lee, Harriet de
Wit
T227. Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary
[11C]-(+)-PHNO Pet Study
Patricia Di Ciano*, Mihail Guranda, Dina Lagzdins, Rachel Tyndale,
Islam Gamaleddin, Peter Selby, Isabelle Boileau, Bernard Le Foll
T228. Buprenorphine Reduces Perception of Negative Social Stimuli in
Healthy Young Adults
Anya Bershad*, Harriet de Wit
T229. SERT Inhibition Modulates Molecular and Behavioral Effects Arising
From Non-Serotonergic Cocaine Targets
Linda D. Simmler*, Paul J. Gresch, Jing Wang, Allison M.J.
Anacker, Jeremy Veenstra-Vanderweele, Bing Zhang, Randy D.
Blakely
237
11/10/15 9:58 AM
T230. Evidence of Incubation of Cue-Induced Craving in Human Individuals
With Cocaine Use Disorder: Objective Bottom-Up Measures Diverge
From Self-Reports in Support of Preclinical Studies
Muhammad Parvaz*, Scott Moeller, Rita Goldstein
T231. Estimated Probability of Becoming Alcohol Dependent: Extending a
Multiparametric Approach
Olga Vsevolozhskaya*, James Anthony
T232. Buprenorphine During Pregnancy: Clearance, Fetal Exposure and
Neonatal Outcomes
Jessica Coker*, Cody McLeod, Sreedharan Narayanan, Thomaas
David, James Ritchie, Michael Mancino, Zachary Stowe
T233. A Novel CRF-VTA Microcircuit in the Mouse Midbrain as Critical Site
for Social Stress to Escalate Cocaine Self-Administration
Kyle Gobrogge, Andrew Hooper, Xiao Han, Elizabeth Holly, Joseph
DeBold, Jamie Maguire, Klaus Miczek*
T234. Adverse Effects of Cannabis on Adolescent Brain Development: A
Longitudinal Study
Jazmin Camchong*, Kelvin Lim, Sanjiv Kumra
T235. Distinct Dorsal and Ventral Hippocampal Inputs to Lateral Septum Drive
Context vs. Cue-Induced Cocaine Seeking
Ellen McGlinchey*, Gary Aston-Jones
T236. Methamphetamine Preference in Female Rats in the Conditioned Place
Preference Test Increases With Altitude
Shami Kanekar, Olena Bogdanova, Paul Olson, Houda Nizam,
Hendrik Ombach, Chloe Renshaw, Young Hoon Sung, Perry
Renshaw*
T237. Behavioral Effects of Tobacco Smoke Constituents in Squirrel Monkeys
Rajeev I. Desai*, Katherine A. Sullivan, Jack Bergman
238
11/10/15 9:58 AM
T238. Orbitofrontal Cortex Neurons are Activated During Alcohol and Sucrose
Seeking
John Hernandez, David Moorman*
T239. Midbrain Functional Connectivity and Ventral Striatal Dopamine D2Type Receptors: Link to Impulsivity in Methamphetamine Users
Milky Kohno*, Chelsea Robertson, Kyoji Okita, Angelica Morales,
Andy Dean, Dara Ghahremani, Fred Sabb, Richard Rawson, Mark
Mandelkern, Robert Bilder, Edythe London
T240. Coupling Between Corticostriatal Structural and Functional Connectivity
is Disrupted in Methamphetamine Dependence
Angelica Morales*, Milky Kohno, Edythe London
T241. Contribution of Withdrawal-Induced Neurogenesis to Drug ContextInduced Reinstatement of Methamphetamine-Seeking Behavior in Rats
Melissa Galinato, McKenzie Fannon, Roberto Morales, Michelle
Brewer, Heather Cameron, Chitra Mandyam*
T242. Systemic Oxytocin Acts Within the Nucleus Accumbens Core to
Attenuate Methamphetamine Seeking
Brittney Cox*, Brandon Bentzley, Ronald See, Carmela Reichel,
Gary Aston-Jones
T243. Resting State Functional Connectivity of the Basal Nucleus of Meynert
in Cigarette Smokers: In Comparison With the Ventral Striatum and
Gender Differences
Sheng Zhang, Sien Hu, Chiang-shan Li*
T244. Adverse Effects of Cannabis on Adolescent Brain Development: A
Longitudinal Study
Jazmin Camchong, Kelvin Lim*, Sanjiv Kumra
T245.Withdrawn
239
11/10/15 9:58 AM
T246. Glucocorticoid Regulation of Food Reward in Humans: Evidence From
Cushing’s Disease
Eliza Geer*, Scott Moeller, Lizette Couto, Ross Haber, Nyima
Yangdhar, Vanessa Cohen, Yelena Lalazar, Iouri Makotkine,
Nikolaos Daskalakis, Nia Williams, Rachel Yehuda, Rita Goldstein
T247. Synapse-Specific Persistent Activation of VTA Kappa Opioid Receptors
Following Acute Stress
Abigail Polter*, Rudy Chen, Ayumi Tsuda, Julie Kauer
T248. Upregulation of Nicotinic Acetylcholine Receptors in Cigarette
Smokers: Effect of Concomitant Heavy Caffeine or Marijuana Use
Arthur Brody*, Hubert Robert, Michael Mamoun, Paul Abraham,
Paulina Young, Ryu Enoki, Lizette Garcia, Mark Mandelkern
T249. Medicine and the Law in the Courtroom: Marijuana as Medicine
Bertha Madras*
T250. Native Rat CB1 Receptor Affinity, Intrisic Activity and Accumbens
Shell Dopamine Stimulant Properties of Third Generation SPICE/K2
Cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135
Maria Antonietta De Luca, Maria Paola Castelli, Barbara Loi,
Alessandra Porcu, Mariella Martorelli, Cristina Miliano, Colin
Davidson, Jaqueline Stair, Fabrizio Schifano, Gaetano Di Chiara*
T251. Nitric Oxide Signaling in the Accumbens Core Drives Relapse to
Cocaine Seeking
Alexander Smith*, Michael Scofield, Jasper Heinsbroek, Peter
Kalivas
T252. Effects of the 5HT2A Serotonin Receptor Inverse Agonist Pimavanserin
on Choice Between Cocaine and Food in Rhesus Monkeys
Matthew Banks*, S. Stevens Negus
240
11/10/15 9:58 AM
T253. Glutamatergic Mechanisms Mediate Enduring Vulnerability to Drug Use
Following an Acute Stressor
Coti Garcia-Keller*, Yonatan Kupchik, Cassandra Gipson-Reichardt,
Robyn Brown, Sade Spencer, Flavia Bollati, Maria A Esparza,
Douglas Roberts-Wolfe, Jasper Heinsbroek, Ana-Clara Bobadilla,
Liliana M. Cancela, Peter Kalivas
T254. Anhedonia Predicts Poorer Outcomes in Contingency Management
for Cocaine Use Disorder, With or Without Levodopa Enhancement of
Treatment
Margaret Wardle*, Jessica Vincent, Robert Suchting, Charles Green,
Scott Lane, Joy Schmitz
T255. Nicotine Causes Parallel Increases in Medial Prefrontal Cortex Gamma
Oscillations and Visual Attention
Nicholas Simon*, Lezio Bueno Jr., Meredyth Wegener, Bita
Moghaddam
T256. FAAH Inhibitor Treatment for Cannabis Dependence
Deepak D’Souza*, Gina Creatura, Jose Cortes-Briones, Halle
Thurnauer, Grai Bluez, Emma Deaso, Toral Surti, Swapnil Gupta,
Aarti Gupta, Mohamed Sherif, Kim Bielen, Mohini Ranganathan,
Patrick Skosnik
T257. Nicotinic Receptor Stimulation Affects Reversal Learning in Smokers
Elise Lesage, Sarah Aronson, Matthew Sutherland, Thomas Ross,
Betty Jo Salmeron, Elliot Stein*
T258. The Circadian Transcription Factor Clock Represses the Expression
of the Dopamine Rate-Limiting Enzyme Tyrosine Hydroxylase via
Recruitment of the Metabolic Sensor SIRT1
Ryan Logan*, Wilbur Williams III, Puja Parekh, Darius BeckerKrail, Spencer Waplinger, Gabrielle Pittman, Hui Zhang, Michelle
Sidor, Colleen McClung
T259. Optical Inhibition of the Infralimbic Cortex Following Unreinforced
Lever Presses Increases Ongoing Cocaine-Seeking Behavior in Rats
Andrea Gutman*, Ryan LaLumiere
241
11/10/15 9:58 AM
T260. Deficient Encoding Leads to Reduced Delayed Recall Among Young
Adult Marijuana Users
Randi Schuster*, Susanne Hoeppner, Jodi Gilman, Anne Eden Evins
T261. Ethanol/Cocaine Interactions: Abuse-Related and Unconditioned
Behaviors in Rhesus Monkeys
Paul Czoty*, William John, Michael Nader, Amy Newman, Phillip
Epperly
T262. Alcohol Sensitivity and Sex Effects on Cardiac Reactivity During Acute
Intravenous Alcohol Exposure in Non-Dependent Drinkers
Bethany Stangl*, Kristin Corey, Reza Momenan, Vijay Ramchandani
242
11/10/15 9:58 AM
Notes
243
11/10/15 9:58 AM
Notes
244
11/10/15 9:58 AM
Poster Session III – Wednesday, December 9, 2015
Illness
Charles R. Harman*
W0.
W1.
rs362691 Polymorphism in RELN Gene Modulates the Detrimental
Effect of Alzheimer’s Disease Risk Genes on Hippocampal Function
Qiang Chen*, Ena Y. Xiao, Aaron L. Goldman, Rahul Bharadwaj,
Kaitlin Healy, Brad Zoltick, Saumitra Das, Karen Berman, Daniel R.
Weinberger, Venkata S. Mattay
W2.
Subtypes of Prefrontal Cortical NMDA Receptors in Working Memory
and Normal Aging
Joseph McQuail, B. Sofia Beas, Kyle Kelly, Kailey Simpson, C.
Jason Frazier, Barry Setlow, Jennifer Bizon*
W3.
A Mitochondrial Role of SV2A Protein in Alzheimer’s Disease: Studies
With Levetiracetam
Walter Mueller*, Carola Stockburger, Kristina Friedland
W4.
Positive Allosteric Modulation of Metabotropic Glutamate Receptor 5
Reverses Deficits in Hippocampal Synaptic Plasticity and Cognitive
Function in a Mouse Model of Alzheimer’s Disease
Jerri M. Rook*, Ayan Goshal, Jonathan W. Dickerson, Gregory N.
Roop, Craig W. Lindsley, P. Jeffrey Conn
W5.
Deconstructing Serotonin Circuits That Mediate Aversion
Catherine Marcinkiewcz, Chris Mazzone, Giuseppe D’Agostino,
Lindsay Halladay, Claudia Cristiano, Andrew Holmes, Tamas
Kozicz, Lora Heisler, Thomas Kash*
245
11/10/15 9:58 AM
Poster Session III—Wednesday
W6.
Corticotropin-Releasing Factor Activates Different Circuits in Male and
Female Rats
Debra Bangasser*, Kimberly Wiersielis, Sarah Cohen, Gerard
Van Buskirk, Dominique Losen, Hamidou Keita, Joy Bergmann,
Nausheen Baksh, Brittany Wicks
W7.
Effects Δ9-Tetrahydrocannabinol (THC) on Brain and Behavior During
Fear Extinction Learning in Humans: A Combined PsychophysiologicalfMRI Study
Stephanie Gorka*, Christine Rabinak, Mohammed Milad, Israel
Liberzon, Stephen Maren, K. Luan Phan
W8.
Effects of Insulin and Diet-Induced-Obesity on Glutamatergic
Transmission in the Nucleus Accumbens and Anxiety-Like Behaviors
Carrie Ferrario*, Max Oginsky, Yanaira Alonso-Caraballo, Aaron
Chadderdon, Peter Vollbrecht, Emily Jutkiewicz
W9.
An Avoidance-Based Rodent Model of Exposure With Response
Prevention Therapy
Jose Rodriguez-Romaguera, Benjamin Greenberg, Steven
Rasmussen, Gregory Quirk*
W10. Anxious Temperament Related mRNA Expression Revealed by
Sequencing RNA From the Central Nucleus of the Amygdala of 46 NonHuman Primates
Andrew Fox*, Tade Souaiaia, Jonathan A. Oler, Jae Mun Kim,
Joseph Nguyen, Patrick H. Roseboom, James A. Knowles, Ned Kalin
W11. Atypical Salience-Default Mode Network Interactions in Pediatric
Obsessive Compulsive Disorder: A Compensatory Role?
Kate Fitzgerald*, Yanni Liu, Robert Welsh, Gregory Hanna, Stephan
Taylor
W12. Heightened Sensitivity to Emotional Expressions in Generalized Anxiety
Disorder Compared to Social Anxiety Disorder and Controls
Eric Bui*, Eric Anderson, Elizabeth Goetter, Allison Campbell, Lisa
Feldman Barrett, Naomi Simon
246
11/10/15 9:58 AM
W13. From Relief to Safety: Omission-Induced Activation of the Nucleus
Accumbens in Fear Conditioning and Extinction
Bram Vervliet*, Marie-France Marin, David Song, Mohammed
Milad
W14. Genetic Influences on Resting EEG Alpha Power in an American Indian
Tribe
Mary-Anne Enoch*, Colin Hodgkinson, Pei-Hong Shen, Qiaoping
Yuan, David Goldman
W15. Chemogenetic Elucidation of the Role of the Orexin System in PanicAssociated Behavior and Physiology
Philip Johnson*, Cristian Bernabe, Lauren Federici, Stephanie Fitz,
Asmaa Mahoui, Andrei Molosh, Seema Bhatnagar, Anantha Shekhar
W16. A Norepinephrine Reuptake Inhibitor, SNRI, Improves Reproductive
Function in Anxious, Stress-Sensitive Female Monkeys With Stress
Induced Infertility
Kevin Todd, Sarah Burns, Tina Liu, Matthew Ragoza, Neal Ryan,
Cynthia Bethea, Judy Cameron*
W17. Prospective Study of Conditioned Fear and Extinction Learning
Performance as a Risk Factor for PTSD in Active Duty Marines
Victoria Risbrough*, Dean Acheson, Dewleen Baker, Caroline
Nievergelt, Mark Geyer
W18. Decrease in Thalamic Volumes of Refractory Patients With ObsessiveCompulsive Disorder who Were Submitted to Gamma Ventral
Capsulotomy
Douglas Costa, Marcelo Batistuzzo, Fabio Duran, Benjamin
Greenberg, Miguel Canteras, Roseli Shavitt, Andre Gentil, Euripedes
Miguel, Antonio Lopes, Marcelo Hoexter*
247
11/10/15 9:58 AM
W19. Myo-Inositol Reduction in Medial Prefrontal Cortex of Obsessive
Compulsive Disorder: A Proton Magnetic Resonance Spectroscopy
Study
Marcelo Batistuzzo*, Marcelo Hoexter, Fabiana Costa, Roseli
Shavitt, Antonio Lopes, Carolina Cappi, Alice de Mathis, Natasha
Senço, Anke Henning, Bruno Pastorello, Claudia Leite, Euripedes
Miguel, Maria Otaduy
W20. Early Emergence of Fear Learning in the Selectively-Bred Anxious Rat
Phenotype
Da-Jeong Chang, Joanna Hider, Regina Sullivan, Huda Akil, Jacek
Debiec*
W21. Posttraumatic Stress Disorder and Common Genetic Variants Affect
Subcortical Brain Volumes in Recent Military Veterans
Sarah Lancaster, Melanie Garrett, Courtney Haswell, Mid-Atlantic
MIRECC Workgroup, Christine Marx, Michael Hauser, Allison
Ashley-Koch, Rajendra Morey*
W22. A Genotype Variant in the Promoter Region of the CRH Gene Interacts
With Early Rearing Experiences to Influence Anxiety-Like Behavior: A
Nonhuman Primate Model
Andrew Aston, Patrick O’Connell, Stephen Lindell, Melanie
Schwandt, Christina Barr, Stephen Suomi, J. Dee Higley*
W23. Posttraumatic Stress Disorder Modulates Neural Activity During ThreatInduced Anxiety and Goal Distraction
Chelsea Swanson, Courtney Haswell, Avani Vora, Christine Marx*,
Rajendra Morey
W24. Hoarding Behaviours Among Users of Online Classified Advertisements
Michael Van Ameringen*, Keren Grosman Kaplan, Zahra Khalesi,
Jasmine Turna, William Simpson, Beth Patterson
W25. High-Reactive Infant Behavior Predicts Reduced Amygdala Volume in
Young Adults
Carl Schwartz*, Pratap Kunwar, Douglas Greve, Stefanie Block,
Rachel Franklin, Jane Viner, Lyndsey Moran
248
11/10/15 9:58 AM
W26. Brain Dynamics of Ongoing Attentional Fluctuations in ADHD
Aaron Kucyi, Michael Hove, Michael Esterman, Joseph Biederman,
Eve Valera*
W27. Combining Autism and Intellectual Disability Exome Data Yields
Insight into Both Disorders
Joseph Buxbaum*, Ercument Cicek, Lambertus Klei, Bernie Devlin,
Kathryn Roeder, for the Autism Sequencing Consortium
W28. Copy Number Variation of the 7q11.23 Williams Syndrome
Chromosomal Region Affects Brain Gyrification and Skull Shape
Michael D. Gregory*, J. Shane Kippenhan, Tiffany Nash, Ranjani
Prabhakaran, Daniel Eisenberg, Lisa Yankowitz, Crystal Insel,
Katherine Roe, Melanie Sottile, Philip Kohn, Carolyn Mervis, Karen
Berman
W29. Prenatal Maternal Smoking Increases Risk for Tourette Syndrome and
Chronic Tic Disorders
Heidi Brown, Amirhossein Modabbernia, Joseph Buxbaum, Stefan
Hansen, Diana Schendel, Erik Parner, Abraham Reichenberg,
Dorothy Grice*
W30. Post-Mortem RNA-seq Characterization of the Histaminergic
Neurotransmitter System in Autism Spectrum Disorders
Carrie Wright*, Joo Heon Shin, Andrew Jaffe, Anindita Rajpurohit,
Nicholas Brandon, Alan Cross, Thomas M. Hyde, Joel Kleinman,
Daniel Weinberger
W31. Ethanol Withdrawal in Adolescent and Adult Rats
Cynthia Kuhn*, Upasana Chandra, Aashna Saini, Weston Fleming,
Reynold Francis, David Walker
W32. Neurodevelopmental Copy Number Variants and Clinical Risk: A
Pediatric Record Population Study
Kwangmi Ahn, Charlly Kao, Frank Mentch, Hakon Hakonarson,
Judith Rapoport*
249
11/10/15 9:58 AM
W33. De Novo Genomic Variation in Non-Autistic Motor Stereotypes
Thomas Fernandez*, Harvey Singer
W34. Neural Correlates of Social Threat Processing and Modulation in Social
Anxiety Disorder
Elizabeth Duval*, Stefanie Block, Mackenna Hill, Cherise White,
Sonalee Joshi, James Abelson, Israel Liberzon
W35. D1 Closes the Sensitive Period Associated With Reduced Addiction Risk
Britta Thompson, Heather Brenhouse, Nadja Freund, Jodi Lukkes,
Kevin Norman, Susan Andersen*
W36. Predicting Behavioral and Emotional Dysregulation Trajectories
in Symptomatic Youth From Structural Neuroimaging: A Machine
Learning Approach
Amelia Versace*, Vinod Sharma, Mary Phillips
W37. Capturing RDoC Reward Constructs in Adolescents With Diverse
Psychiatric Symptoms
Kailyn Bradley*, Junqian Xu, Julia Case, Michael Milham, Emily
Stern, Vilma Gabbay
W38. Depression in Girls During Early Adolescence Predicts Altered Cortical
Midline Response to Social Evaluation in Late Adolescence
Amanda Guyer*, Justin Caouette, Alison Hipwell, Kate Keenan,
Erika Forbes
W39. Hepatic Insulin Sensitivity is Associated With Whole Body Adiposity
Achieved During Initial Antipsychotic Exposure in Youth
Ginger Nicol*, Michael Yingling, Julie Schweiger, John Newcomer
W40. Psychoeducational Group Intervention for Adolescents With Psychosis
and Their Families. A Two-Year Follow-Up: The Piensa Trial
Celso Arango*, Ana Calvo, Miguel Moreno, Ana Ruiz-Sancho,
Marta Rapado-Castro, Carmen Moreno, Teresa Sanchez-Gutierrez,
Maria Mayoral
250
11/10/15 9:58 AM
W41. An Epigenetic Approach for the Modulation of Amyloid Precursor
Protein (APP) Processing and Improvement of Memory in Alzheimer’s
Disease
Claude-Henry Volmar*, Hasib Salah-Uddin, Paul Halley, Guerline
Lambert, Neil Mehta, Andrew Wodrich, David Dorcius, Claes
Wahlestedt
W42. Genetic Interaction Between SORL1 and BDNF Regulates IsoformSpecific SORL1 Expression With Effects on Brain Structure and
Amyloid Pathology
Daniel Felsky*, Jishu Xu, Lori Chibnik, Julie Schneider, James
Kennedy, David Bennett, Philip De Jager, Aristotle Voineskos
W43. High Dose Donepezil Treatment of Alzheimer’s Disease
Thomas Chase*, Kathleen Clarence-Smith
W44. Cerebellar Connectivity and Glutamatergic Metabolite Concentration in
ASD as Assessed by fcMRI/MRS
David Beversdorf*, Dylan Weber, John Hegarty
W45. Dopamine Synthesis and Receptor Profile are Associated With Body
Mass Index in Humans
Angela Ianni*, Daniel Eisenberg, Catherine Hegarty, Joseph Masdeu,
Michael Gregory, Philip Kohn, Karen Berman
W46. Patterned Feeding Promotes Food Addicted Behaviors
Jon Davis*, Sunil Sirohi, Arriel Van Cleef, Ainsley McGregor, Cody
Kowalski, Ryan McLaughlin
W47. Altered Neural Processing of Aversive Interoceptive Stimuli in Adult
Women Recovered From Anorexia Nervosa
Laura Berner*, Alan Simmons, Christina Wierenga, Amanda
Bischoff-Grethe, Martin Paulus, Walter Kaye
W48. Modeling Anorexia Nervosa Using Human iPS Cells
Priscilla Negraes, Fernanda Cugola, Roberto Herai, Alysson Muotri,
Vikas Duvvuri*
251
11/10/15 9:58 AM
W49. Activation of the Corticoaccumbens Circuit Attenuates Inherent
Impulsivity and Binge Intake of High Fat Food
Noelle Anastasio*, Sonja Stutz, Amanda Price, Susan Ferguson, John
Neumaier, Kathryn Cunningham
W50. Kappa Opioid Receptor Activation Disrupts Behavioral Inhibition in
Schedule-Controlled Tasks
Antony Abraham*, Benjamin Land, David Soltys, Charles Chavkin
W51. Psychophysiological Correlates of Escalating and De-Escalating
Behavior During an Aggressive Interaction
Jennifer Fanning*, Royce Lee, Mitchell Berman, Emil Coccaro
W52. Early-Life Experience Reprograms Stress-Sensitive Neurons and
Influences Adult Phenotype via NRSF/REST-Dependent Epigenetic
Mechanisms
Akanksha Singh-Taylor, Jenny Molet, Shan Jiang, Aniko Korosi,
Yuncai Chen, Ali Mortazavi, Tallie Z. Baram*
W53. The Effects of Gabapentin and Pregabalin in the Consolidation and
Reconsolidation of Auditory Threat Memory in Rats
Lorenzo Diaz-Mataix*, Joseph LeDoux
W54.Withdrawn
W55. CorrECTing ConnECTomes: Brain Network Correlates of ECT
Treatment and Response
Olusola Ajilore*, Alex Leow, Christopher Abbott
W56. Lurasidone Adjunctive to Lithium or Divalproex for Prevention of
Recurrence in Patients With Bipolar I Disorder: Results of a 28-Week,
Randomized, Double-Blind, Placebo-Controlled Study
Joseph Calabrese*, Andrei Pikalov, Josephine Cucchiaro, Caroline
Streicher, Jane Xu, Antony Loebel
252
11/10/15 9:58 AM
W57. A Novel Study Design to Evaluate the Rapid Reduction of the
Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in
Subjects Assessed to Be at Imminent Risk for Suicide
Carla Canuso*, Jaskaran Singh, Maggie Fedgchin, Larry Alphs,
Rosanne Lane, Christine Pinter, Wayne Drevets
W58. Ventral Tegmental Area Muscarinic Acetylcholine Receptor Mechanisms
Mediating Responses to Stress and Anxiety in Preclinical Models
Nii Addy*, Keri Small, Wojciech Solecki, Benjamin Land, Eric
Nunes, Robert Wickham, Cali Calarco, Marina Picciotto, Ralph
DiLeone
W59. Susceptibility to Chronic Social Defeat Stress is Associated With
Profound Alterations of the Brain Pituitary Adenylate Cyclase-Activated
Polypeptide (PACAP) System
Clara Velazquez-Sanchez, Antonio Ferragud, Diane Tang, Carlos
Santiago-Medero, Pietro Cottone, Valentina Sabino*
W60. Seasonal Variation in Serotonin Transporter Binding in Seasonal
Affective Disorder and Health: A [11C]DASB Positron Emission
Tomography Study
Andrea Tyrer*, Robert Levitan, Sylvain Houle, Alan Wilson, Jose
Nobrega, Jeffrey Meyer
W61. Exploration of the Interrelationship Between Cytokines and Other
Inflammatory Markers Across MDD Cohorts
Lynn Yieh*, Xiang Yao, Femke Lamers, Brenda Penninx, Andrew
Miller, Christian Thomsen, Giacomo Salvadore, James Palmer,
Jaskaran Singh, Wayne Drevets, Gayle Wittenberg, Guang Chen
W62. Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons
Drive Aversion and Reward
Ream Al-Hasani*, Jordan McCall, Jenny Wong, Gunchul Shin,
Adrian Gomez, Gavin Schmitz, Julio Bernardi, Omar Mabrouk,
Chang-O Pyo, Sung Il Park, Catherine Marcinkiewcz, Nicole
Crowley, Michael Krashes, Bradford Lowell, Thomas Kash, John
Rogers, Robert Kennedy, Michael Bruchas
253
11/10/15 9:58 AM
W63. Striatal Sub-Region Resting State Connectivity in Bipolar Depression
and Mania
Murat Altinay, Leslie Hulvershorn, Harish Karne, Erik Beall, Amit
Anand*
W64. The Adrenergic-Cholinergic Hypothesis of Affective Disorders Revisited
David Janowsky*
W65. Neural Substrates of Social Exclusion in Recent Suicide Attempters
Ricardo Caceda*, George James, Zachary Stowe, Clinton D. Kilts
W66. Ketamine Treatment Translocates Gsalpha From Lipid Rafts in Cultured
Glial Cells: Similar Effects to Several Antidepressant Compounds
Nathan Wray, Jeffrey Schappi, Mark Rasenick*
W67.Withdrawn
W68. Connectivity Analysis of EEG in Depressed Patients Receiving
Electroconvulsive Therapy and Magnetic Seizure Therapy
Zhi-De Deng*, Shawn McClintock, Sarah Lisanby
W69. Dysregulation of Striatal Dopamine Receptor Binding in Suicide and by
Early Life Adversity
Megan Fitzgerald*, Suham Kassir, Mark Underwood, Mihran
Bakalian, J. Mann, Victoria Arango
W70. Novel Molecular Signatures of Antidepressant Treatment Response
Christoph Anacker*, Benjamin A. Samuels, Michael J. Meaney,
Rene Hen
W71. Lithium Decreases Markers of Inflammation in an Animal Model of
Mania
Joao de Quevedo*, Meagan Pitcher, Samira da Silva Valvassori,
Paula Tonin, Roger Varela, Andre Carvalho, Edemilson Mariot,
Rafaela Amboni, Guilherme Bianchini, Monica Andersen
254
11/10/15 9:58 AM
W72. Alterations in Cortical and Striatal Oprk1, PDYN and Oprm1 mRNA
Expression May Underlie the Behavioral Effects of Buprenorphine in
Unpredictable Chronic Mild Stress
Caroline Browne*, Edgardo Falcon, Rosa Leon, Vanessa Fleites,
Irwin Lucki
W73. HIV-1 Disrupts Motivational Processes via Dopamine Transporter
Dysregulation
Rose Marie Booze*, Steven Harrod, Sarah Bertrand, Michael
Cranston, Charles Mactutus
W74. Targeting FKBP51 Mechanisms to Treat PTSD and Related Disorders
Jonathan Sabbagh, Laura Blair, Elisabeth Binder, Chad Dickey*
W75. Kappa Opioid Receptors Modulate Mammalian Target of Rapamycin
(mTOR) Through p38 MAP Kinase
Benjamin Land*, Selena Schattauer, Talia Suner, Charles Chavkin
W76. Subgenual Cingulate Cortical Activity and Connectivity in the
Antidepressant Efficacy of Electroconvulsive Therapy
Miklos Argyelan*, Todd Lencz, Styliani Kaliora, Deepak Sarpal,
Noah Weissman, Peter Kingsley, Anil Malhotra, Georgios Petrides
W77. Neurocognitive Clustering in Bipolar Disorder Patients and Their
Unaffected Siblings
Manuela Russo*, Elizabeth Ramjas, Megan Shanahan, Armando
Cuesta-Diaz, Mercedes Perez-Rodriguez, Katherine Burdick
W78. Exploratory Genome-Wide Association Study of Acute Antidepressant
Effects of Ketamine
Rodrigo Machado-Vieira*, Wei Guo, James Murrough, Sanjay
Mathew, Michael Grunebaum, Dennis Charney, Dan Iosifescu, Yin
Yao, Francis McMahon, Carlos Zarate Jr.
W79. Reduced Dopamine Transporter Function Enhances Probabilistic
Learning, an Effect Blocked by Lithium
Jared Young*, Mary Graves, Jordy van Enkhuizen, Mark Geyer,
Morgane Milienne-Petiot
255
11/10/15 9:58 AM
W80. Social Buffering: Circuit Mechanisms of a Stress Coping Strategy
Allyson Friedman*, Barbara Juarez, Stacy Ku, Hongxing Zhang,
Ming-Hu Han
W81. Effects of Repeated Lipopolysaccharide (LPS) Injections on AnxietyLike Behavior and Brain Serotonin in Female BALB/cJ Mice
Cristina Sánchez*, Cynthia Kuhn, Florian Daniel Zepf
W82. What is the Nature of the Verbal Memory Deficit in Bipolar Disorder? A
Discordant Sibling Pair Study
Armando Cuesta-Diaz*, M. Mercedes Perez-Rodriguez, Elizabeth
Ramjas, Manuela Russo, Megan Shanahan, Katherine Burdick
W83. Effect of Subacute and Sustained Administration of Vortioxetine on
Catecholaminergic Systems
Pierre Blier*, Mohammad Ebrahimzadeh, Mostafa El Mansari
W84. Involvement of SSAT in Depression in Post-Mortem Brains
Adolfo Sequeira, Firoza Mamdani, Agenor Limon-Ruiz, Brandi
Rollins, Ling Morgan, William Bunney, Marquis Vawter*
W85. Resting-State Functional Connectivity of Anterior Insula Differentiates
Bipolar and Unipolar Depression
Kristen Ellard*, Jared Zimmerman, Samuel Zorowitz, Joshua
Roffman, Koene Van Dijk, Darin Dougherty, Thilo Deckersbach,
Joan Camprodon
W86. Genome-Wide Association Analyses on Clinical Response to Duloxetine
and Placebo in Major Depression Implicates a Gene Locus Involved in
Nociception to be Associated With Placebo Response
Daniel Mueller*, Malgorzata Maciukiewicz, Victoria Marshe, Arun
Tiwari, Trehani Fonseka, Natalie Freeman, James Kennedy, Susan
Rotzinger, Jane Foster, Sidney Kennedy
W87. Combinatorial Pharmacogenomics for Personalized Antidepressant
Therapy: Clinical and Economic Validity and Utility
Balmiki Ray*, Joel Winner, Josiah Allen, Joseph Carhart, Bryan
Dechairo, C. Anthony Altar
256
11/10/15 9:58 AM
W88. Clinical Outcomes Associated With Comorbid Posttraumatic Stress
Disorder Among Patients With Bipolar Disorder
Giovanna Zunta-Soares, Ives Passos, Joao de Quevedo, Jair Soares*
W89. Inflammation and Neurocognition in Bipolar Disorder
Katherine Burdick*, Manuela Russo, Megan Shanahan, Armando
Cuesta-Diaz, M. Mercedes Perez-Rodriguez
W90. Electroconvulsive Therapy (ECT) Modulation of Reward Processing and
Circuit Dynamics in Depression
Joan Camprodon*, Jared Zimmerman, Kristen Ellard, Peggy Chau,
Navneet Kaur, Nikos Makris, Maurizio Fava, Darin Dougherty
W91. The Efficacy of a Comprehensive Yogic Intervention on Major
Depression – A Randomized Pilot Study With Inflammatory Biomarkers
Anup Sharma*, Frank Rose, Tamar Halpern, Mary Foley, Marna
Barrett, Michael Thase
W93. Systematic Review and Meta-Analysis: Dose-Response Relationship of
Selective-Serotonin Reuptake Inhibitors in Major Depressive Disorder
Ewgeni Jakubovski, Anjali Varigonda, Nicholas Freemantle,
Matthew Taylor, Michael Bloch*
W94. Habenular Endocannabinoid Signaling Participates in Behavioral and
Neuroendocrine Responses to Stress
Anthony Berger, Ryan McLaughlin*
W95. Ketamine-Induced Inhibition of Glycogen Synthase Kinase-3
Contributes to the Augmentation of AMPA Receptor Signaling
Eleonore Beurel*, Richard Jope
W96. Epigenetic Mechanisms of Hippocampal Plasticity: P300-Driven mGlu2
Up-Regulation Mediates Resilience and Antidepressant Responses
Carla Nasca*, Benedetta Bigio, Danielle Zelli, Aleksander Mathe,
Bruce McEwen
257
11/10/15 9:58 AM
W97. Neuroendocrine and Behavioral Effects of Cort 118335, a Novel
Glucocorticoid and Mineralocorticoid Receptor Antagonist in Male Rats
Matia Solomon*, Elizabeth Nguyen, Sarah Berman, Joshua
Streicher, Aynara Wulsin, Jody Caldwell
W98. Female Rats Exhibit Lower Baseline Dopamine Neuron Activity
and Higher Depression Behavior That is Exacerbated in the UCMS
Depression Model: Impact of Ketamine
Millie Rincón-Cortés*, Anthony Grace
W99. Factor Analysis of Temperament and Personality Traits in Bipolar
Patients: Correlates With Comorbidity and Disorder Severity
Tiffany Greenwood*, Frank Qiu, Hagop Akiskal, John Kelsoe
W100.Categorization and Tractographical Correlation of Acute Intraoperative
Behavioral Responses to Subcallosal Cingulate Deep Brain Stimulation
Patricio Riva Posse*, Ki Sueng Choi, Andrea Crowell, Robert Gross,
Steven Garlow, Helen Mayberg
W101.Why 7 Tesla fMRI is Needed to Study DEPRESSION?
Marta Moreno-Ortega*, Oded Gonen, Mariana Lazar, Daniel Javitt,
Tarique Perera, Alayar Kangarlu
W102.Tuning Circuits With Interleaved TMS/fMRI: One Session of 10Hz
Left Dorsolateral Prefrontal Cortex rTMS (4000 pulses) Increases the
Cortical and Decreases the Striatal Bold Signal Response to a TMS
‘Ping’ of That Circuit
Bashar Badran, Joseph Taylor*, William DeVries, Lisa McTeague,
Xingbao Li, Colleen Hanlon, Mark George
W103.Seizure Initiation With Focal Electrically Administered Seizure Therapy
(FEAST)
Kawthar Al Ali, Mark Doumit, Mia Atoui, Amira Zaylaa, Fadi
Karameh, Ziad Nahas*
W105.Use of Mobile Technologies to Monitor Activity, Sleep, and Mood States
to Identify Targets of Prevention of Mood Disorders
Ian Hickie*, Elizabeth Scott, Kathleen Merikangas
258
11/10/15 9:58 AM
W106.Inflammation-Related Decreases in Dopamine and Effects on
Corticostriatal Reward Circuitry: Evidence From Humans and NonHuman Primates
Jennifer Felger*, Zhihao LI, Ebrahim Haroon, Bobbi Woolwine,
Xiaoping Hu, Andrew Miller
W107.Sex Differences in Cytokine Networks in the Hippocampus After
Systemic Immune Challenge
Natalie Tronson*, Lacie Turnbull
W108.Effects of Ketamine on Tests of Antidepressant Efficacy and StressInduced Anhedonia in Rats
Andre Der-Avakian*, Athina Markou
W109.Associations Between Increased C-Reactive Protein, Emotional
Dysregulation, and Depression in a Sample of Trauma-Exposed AfricanAmerican Women With Type 2 Diabetes Mellitus
Charles Gillespie*, Abigail Powers, Rachel Gluck, Joseph Wilson,
Hayley Dixon, Adam Munoz, Vasiliki Michopoulos, Guillermo
Umpierrez, Kerry Ressler, Tanja Jovanovic, Thaddeus Pace
W110.Variability in Sleep Duration Mediates the Relationship Between
Chronic Stress and Symptoms of Depression and Anxiety in Midlife
Women: The SWAN Sleep Study
Melynda Casement*, Chris Kline, Karen Matthews, Howard Kravitz,
Joyce Bromberger, Sioban Harlow, Huiyong Zheng, Fanyin He,
Martica Hall
W111. The Challenge: Estimating the Onset of Drug Effect in the STAR*D
Data
Yin Yao*, Francis McMahon
W112.Cortical Inhibition in the Pathophysiology and ECT Treatment of Major
Depressive Disorder
Daphne Voineskos*, Andrea Levinson, Daniel Blumberger, Yinming
Sun, Faranak Farzan, Zafiris J. Daskalakis
259
11/10/15 9:58 AM
W113.In Vivo Proton Magnetic Resonance Spectroscopy Study of the
Relationships Between Lactate, Depression Severity, and Ketamine
Treatment in Major Depressive Disorder
Kyle Lapidus*, James Murrough, Xiangling Mao, Todd Ogden,
Marc Dubin, Jaclyn Schwartz, Dan Iosifescu, Sanjay Mathew,
Dennis Charney, Dikoma Shungu
W114.Concurrent Benzodiazepine Treatment Delays Antidepressant Response
to Repeat Dose of Intravenous Subanesthetic Ketamine in Treatment
Resistant Depression
Cristina Albott*, Paulo Shiroma, Paul Thuras, Jose Pardo, Kelvin
Lim
W115.The Actions of Corticotropin Releasing Hormone in the Nucleus
Accumbens
Julia Lemos*, Michael Montesino, Miriam Bocarsly, Michael Clark,
Veronica Alvarez
W116.A Single Dose of SSRI Alters the Neural Circuit Underlying the
Management of Attentional Resources to Emotional Distraction Within 3
Hours
Claudia Barth, Hadas Okon-Singer, Lina Schaare, Lydia Hellrung,
Jöran Lepsien, Inga Burmann, Arno Villringer, Julia Sacher*
W117.Phasic Locus Coeruleus Activity Regulates Cortical Processing of
Salience
Elena Vazey*, David Moorman, Gary Aston-Jones
W118.Sex Differences in Fear Conditioning and Extinction in Trauma-Exposed
Individuals With and Without Post-Traumatic Stress Disorder
Rachel Zsido, Diana Cagliero, Huijing Song, Mohammed Milad*,
Marie-France Marin
W119.Associations of White Matter Integrity With Discrepancies Between
Verbal and Performance IQ
Amy Margolis*, Ravi Bansal, Bradley Peterson
260
11/10/15 9:58 AM
W120.Skin Conductance Responses and Neuroimaging Correlates of Fear
Conditioning and Fear Renewal in Healthy Controls and Traumatized
Individuals With and Without Post-Traumatic Stress Disorder
Marie-France Marin*, Javier Weddington, Rachel Zsido, Huijing
Song, Natasha Lasko, Mohammed Milad
W121.Development, Safety, and Tolerability of Transcutaneous Auricular
Vagus Nerve Stimulation (taVNS), a Novel Form of Noninvasive Vagus
Nerve Stimulation
Bashar W. Badran*, Chloe E. Glusman, Alan W. Badran, Christopher
Austelle, William H. DeVries, Jeffrey J. Borckardt, Mark S. George
W122.Lower Dorsolateral Prefrontal Cortex Activation is Associated With
Higher Self-Transcendence in Healthy Controls Taking Clomipramine
Jorge Almeida*, Clarice Gorenstein, Linda Carpenter, Mary Phillips,
Carlos Cerqueira, Monica Zilberman, Daniela Lobo, Elena Henna,
Hermano Tavares, Edson Amaro, Claudia Leite, Valentin Gentil,
Geraldo Busatto
W123.A Novel Strategy for Delivering Candidate Therapeutics to Dopamine
Neurons
Bertha Madras*, Peter Meltzer, Ali Bonab, Alan Fischman
W124.Cortical Structure and Religious Use of Ayahuasca
Jessica Pommy*, Michael Bogenschutz, Paulo Cesar Ribeiro
Barbosa, Robert Thoma, Jessica Turner
W125.Pharmacological Characterization of the Novel M1 Positive Allosteric
Modulator Compound 25
Sarah Grimwood*, Keith Dlugolenski, Jeremy Edgerton, John
Lazzaro, Susan Lotarski, Michael Popiolek, Veronica Reinhart,
Stefanus Steyn, Lei Zhang, Jennifer Davoren
W126.Examining the Effects of Microbiome Depletion on the Behavioral
Phenotypes of Selectively Bred High-and Low-Responder Rats
Ignacio Rivero-Covelo, Shinji Fukuda, Huda Akil, Shelly Flagel*
261
11/10/15 9:58 AM
W127.In Vivo Serotonin Chemistry and Local Cytoarchitecture: A Combined
Voltammetric, Mathematical and Microscopy Study
Parastoo Hashemi*, Aya Abdalla, Yunju Jin, Janet Best, David
Linden, Michael Reed
W128.Clathrin Nanoparticles Efficiently Deliver Antibodies to Targeted
Dopamine Brain Regions
Gordana Vitaliano*, Franco Vitaliano, Jose Rios, Tatyana Kramer,
Perry Renshaw, Martin Teicher
W129.Results of a Survey of Clinician Rated Outcome Measures in
International CNS Clinical Trials
Amir Kalali*, Richard Keefe, Elizabeth Pappadopulos, Monika
Vance
W130.Generation of a Functional Human Cortex From Pluripotent Stem Cells
Steven Sloan, Anca Pasca, Laura Clarke, Yuan Tian, Chul-Hoon
Kim, Jin-Young Park, Nancy O’Rourke, Stephen Smith, Daniel
Geschwind, Ben Barres, Sergiu Pasca*
W131.Neural Architecture of a Pair Bond: Calcium Imaging of the Nucleus
Accumbens in Awake-Behaving Prairie Voles
Zoe Donaldson*, Elena Carazo, Jennifer Scribner, Ashley
Cunningham, Mazen Kheirbek, Rene Hen
W132.Comparison of Antipsychotic Medication Related Cardiometabolic Risk
Factors in Patients With Psychotic vs. Non-Psychotic Disorders and a
Control Group
Jayesh Kamath*, Tatjana Dujmovic, Yinghui Duan, Helen Wu,
Victoria Scranton
W133.Reduced Between-Network Connectivity Following Exercise in
Overweight/Obese Adults
Kristina Legget*, Korey Wylie, Marc-Andre Cornier, Edward
Melanson, Jason Tregellas
262
11/10/15 9:58 AM
W134.Comparing Connectomes Using Anatomical Connectivity Within
Extended Reward Network Regions Across Male and Female Obese
Subjects
Arpana Gupta*, Emeran Mayer, Connor Fling, Mher Alaverdyan,
Kirsten Tillisch, Claudia Sanmiguel, Jennifer Labus
W135.Novel Human Evidence of Psychosocial Stress-Induced Changes in IL18: A Potent and Ubiquitous IL-1 Family Cytokine
Alan Prossin*, Stephanie Meyer, James Abelson
W136.Linking PFC Internal Capsule Pathways With FA Values: Implications
for Relating Abnormalities in Disease to Specific Connections
Giorgia Grisot*, Suzanne Haber
W137.Novel Bold Activity Dynamics in Response to Anesthesia Modulation
Observed Using Wide-Spectrum Functional MRI
Prantik Kundu*, Paula Croxson
W138.Preclinical Characterization of MIN-301, a Neuregulin-1 Fragment, as a
Potential Disease-Modifying Therapy for Parkinson’s Disease
Nadine Noel, Sandra Werner, David Lowe, Michael Detke*, Remy
Luthringer
W139.PRC2 Regulates Transcriptional and Behavioral Phenotypes Induced by
Mutant Huntingtin
Robert Fenster*, Adrian Heilbut, Ruth Kulicke, Alex Powers, Lea
Hachigian, Myriam Heiman
W140.Functional Characterization of a Novel ‘Reader’ of Neuronal Chromatin,
BRWD1, in Down Syndrome Associated Neurological Impairment
Ashley Lepack, Lorna Farrelly, Yang Lu, Wendy Wenderski, Tom
Muir, Haitao Li, Randall Roper, Kristen Brennand, Ian Maze*
W141.Gut-Derived Metabolites Involved in Tryptophan Metabolism Are
Associated With Brain Morphology
Jennifer Labus*, Arpana Gupta, Mher Alaverdyan, Kirsten Tillisch,
Emeran Mayer
263
11/10/15 9:58 AM
W142.Use of Inhibitory Conditioned Cues to Reduce Alcohol-Seeking: PreExposure Blocks Enhancement of Alcohol-Seeking Produced by an
Excitatory Conditioned Cue
Gerald Deehan Jr., Christopher Knight, William McBride, Sheketha
Hauser, Zachary Rodd*
W143.Nociceptive Neural Transcriptional Plasticity in Rat Dorsal Horn in a
Persistent Pain Model
Michael Iadarola*, Matthew Sapio, Andrew Mannes
W144.Amygdala-Independent Pathways Involved in the Generation of
Interoceptive Fear
Justin Feinstein*, Sahib Khalsa, Martin Paulus, Lori Haase, Ralph
Adolphs, Rene Hurlemann
W145.Interaction of Childhood Trauma and COMT Genotype on Hippocampal
Activation During Inhibition: Potential Mechanism for Psychiatric Risk
or Resilience?
Sanne van Rooij*, Jennifer Stevens, Timothy Ely, Negar Fani,
Alicia Smith, Kimberly Kerley, Adriana Lori, Kerry Ressler, Tanja
Jovanovic
W146.Oxytocin Receptor Gene (OXTR) Variation, Fear and Reward
Sensitivity in Rhesus Macaque and Non-Traditional Model Animals
Carlos Driscoll*, Stephen Lindell, Maelys Yepes, Isaac Miller-Cruse,
Clay Stephens, Sue McDonnell, Christina Barr
W147.Endocannabinoids and Neuropeptides in CSF and Serum From
Borderline Personality Disorder Patients
Dagmar Koethe, Emanuel Schwarz, Carola Schaefer, Frank Enning,
Juliane K. Mueller, Jan Malte Bumb, Sabine Herpertz, Christian
Schmahl, Martin Bohus, F. Markus Leweke*
W148.Exome Sequencing of Borderline Personality Disorder Patients to
Identify Functional Rare Variants
Colin Hodgkinson*, M. Mercedes Perez-Rodriguez, Qiaoping
Yuan, Ming Leung, Monica Prat, Miguel Casas, Marc Ferrer, Marta
Ribases, Oscar Andion, Antonia New, Larry Siever, David Goldman
264
11/10/15 9:58 AM
W149.Early Postnatal GABAa Receptor Modulation Reverses Deficits in
Neuronal Maturation in a Conditional Neurodevelopmental Mouse
Model of DISC1
Atsushi Saito, Yu Taniguchi, Matthew Rannals, Emily Merfeld,
Michael Ballinger, Minori Koga, Yoshikazu Ohtani, David Gurley,
Thomas Sedlak, Alan Cross, Stephen Moss, Nicholas Brandon,
Brady Maher, Atsushi Kamiya*
W150.A New Platform to Improve Quality of PANSS and MADRS
Administration
Janet Williams*, Barbara Echevarria, Douglas Osman, Lori Garzio,
Michael Detke
W151.DRD2- AKT1/ AKT3 Epistasis Effects on Neuroimaging Complex
Phenotypes Add Evidence for the D2 Receptors’ Signaling via Akt
Pathways
Eugenia Radulescu*, Qiang Chen, Joseph H. Callicott, Ena Xiao,
Karen F. Berman, Venkata S. Mattay, Daniel R. Weinberger
W152.Relationship of Frontal Dopamine D2/3 Receptor Blockade to Cognitive
Functions in Initially Antipsychotic-Naïve First-Episode Schizophrenia
Patients
Henrik Nørbak-Emig, Bjørn H. Ebdrup, Birgitte Fagerlund, Claus
Svarer, Egill Rostrup, Lars Pinborg, Birte Glenthoj*
W153.Immune Involvement in the Pathogenesis of Schizophrenia: A MetaAnalysis on Post-Mortem Brain Studies
Charissa van Kesteren, Iris Sommer*
W154.Effects of Aripiprazole Once-Monthly and Paliperidone Palmitate in
Patients With Schizophrenia and Concomitant Substance Use: A PostHoc Analysis of QUALIFY, a Head-To-Head Study
Dieter Naber*, Ross A. Baker, Anna Eramo, Carlos Forray, Karina
Hansen, Christophe Sapin, Maud Beillat, Phyllis Salzman, Timothy
Peters-Strickland, Anna-Greta Nylander, Peter Hertel, Jean-Yves
Loze, Henrik Steen Anderson, Steven G. Potkin
265
11/10/15 9:58 AM
W155.Fibroblast Growth Factor 14 is an Essential Element of the Inhibitory
Circuit That Controls Cognitive Function Associated With Schizophrenia
Tahani K. Alshammari, Musaad A. Alshammari, Miroslav N. Nenov,
Eriola Hoxha, Marco Cambiaghi, Andrea Marcinno, Thomas F.
James, Pankaj Singh, Demetrio Labate, Jiang Li, Herbert Y. Meltzer,
Benedetto Sacchetti, Filippo Tempia, Fernanda Laezza*
W156.Metabotropic Glutamate Receptor 5 Binding in Individuals With
Schizophrenia
Funda Akkus, Valerie Treyer, Simon Ametamey, Cyrill Burger, Anass
Johayem, Alfred Buck, Gregor Hasler*
W157.The Neurobiology of Simulated Real-World Effortful Behavior Deficits
in Schizophrenia
George Foussias*, Ishraq Siddiqui, Colin Hawco, Gagan Fervaha,
John Zawadzki, Martin Lepage, Konstantine Zakzanis, Albert Wong,
Aristotle Voineskos, Gary Remington
W158.Diagnostic Specificity in Adult Patients With Schizophrenia and Autism
Assessed With Regional MRI Brain Volume Inter-Correlations and
Dendritic Tree Analysis
Monte Buchsbaum*, Serge Mitelman, Marie-Cecile Bralet, Erin
Hazlett, Mehmet M. Haznedar, Lina Shihabuddin
W159.Early Life Exposure to Metals and Schizophrenia: A Proof-of-Concept
Study of Tooth as a Novel Biomarker
Abraham Reichenberg*, Amirhossein Modabbernia, Eva Velthorst,
Lieuwe De Haan, Nathalie Franke, Arjen Sutterland, Josephine
Mollon, Manish Arora, Robert Wright
W160.Acute Inhibition of ErbB4 Tyrosine Kinase by a Chemical-Genetic
Approach Impairs Synaptic Plasticity and Causes SchizophreniaAssociated Behavioral Deficits
Zhibing Tan*, Dongmin Yin, Fang Liu, Hongsheng Wang, Huifeng
Jiao, Wen-Cheng Xiong, Lin Mei
266
11/10/15 9:58 AM
W161.Assessing Reward Learning in Macaques Using a Probabilistic Selection
Task
Courtney Glavis-Bloom, Daniela Alberati, Theresa Ballard, Matthew
Croxall, Kirsten Taylor, Daniel Umbricht, Tanya Wallace*
W162.Lurasidone is an Effective Treatment for Treatment Resistant
Schizophrenia
Herbert Meltzer*, D. Barrett Share, Karu Jayathilake
W163.7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate
Cortex in Schizophrenia
Meredith Reid*, Nouha Salibi, Thomas Denney, Adrienne Lahti
W164.Oxytocin Modulation of Neural Circuitry for Trust in Schizophrenia: A
fMRI Study
Naren Rao*, Arpitha Jacob, Shivaram Varambally, Rose Bharath,
Ganesan Venkatasubramanian, Bangalore Gangadhar
W165.General Intelligence and Associated fMRI Networks in Schizophrenia
Joseph Callicott*, Dwight Dickinson, Daniel Weinberger, Karen
Berman
W166.Clinical Development of ITI-007 for the Treatment of Schizophrenia
Kimberly Vanover, Robert Davis, Cedric O’Gorman*, Jelena
Saillard, Michal Weingart, Sharon Mates
W167.Dimensional Traits of Psychosis Associated With NMDA Receptor
GRIN2B Polymorphism
Anvi Vora, Antonia New, Erin Hazlett, Qiaoping Yuan, Zhifeng
Zhou, Colin Hodgkinson, David Goldman, Larry Siever, Panos
Roussos, M. Mercedes Perez-Rodriguez*
W168.Antipsychotic Pharmacogenomics: Neuronal Development,
Neurotransmission, and Glutamate Gene Associations With Treatment
Response
Jeffrey Bishop*, James Stevenson, James Reilly, Margret Harris,
Konasale Prasad, Judith Badner, Vishwajit Nimgaonkar, Matcheri
Keshavan, John Sweeney
267
11/10/15 9:58 AM
W169.Open Translational Science in Schizophrenia
Marsha Wilcox, Adam Savitz, Carla Canuso, Husseini Manji*
W170.Efficacy of Dopamine D2 Receptor β-Arrestin-Biased Ligands on
Schizophrenia-Like Behaviors in Mutant Mice
William C. Wetsel*, Claire M. Schmerberg, Meng Chen, Ramona M.
Rodriguiz, Su Mi Park, Xin Chen, Marc G. Caron, Jian Jin
W171.Dopamine-Dependent Working-Memory Performance is Mediated by
Dynamic Connectivity Between Brain Networks
Clifford Cassidy, Jared Van Snellenberg, Caridad Benavides, Mark
Slifstein, Zhishun Wang, Holly Moore, Anissa Abi-Dargham,
Guillermo Horga*
W172.Safety of Lurasidone in Older Adults With Schizophrenia: A Pooled
Analysis of Short-Term Placebo-Controlled Studies
Steven Potkin*, Michael Tocco, Andrei Pikalov, Jay Hsu, Josephine
Cucchiaro, Antony Loebel
W173.Mechanisms Governing Muscarinic LTD in the Prefrontal Cortex
Implicated in Negative and Cognitive Symptoms of Schizophrenia: Role
of mGlu5 and GABAa Receptors
Ayan Ghoshal*, Sean Moran, Jerri Rook, Jonathan Dickerson, Craig
Lindsley, P. Jeffrey Conn
W174.Further Characterizing Brain Receptor Occupancy With ITI-007: Results
From a Positron Emission Tomography (PET) Study in Patients With
Schizophrenia
Kimberly Vanover*, Robert Davis, Yun Zhou, James Brasic, Weiguo
Ye, Cedric O’Gorman, Jelena Saillard, Michal Weingart, Robert
Litman, Sharon Mates, Dean Wong
W175.Association of Serotonin2c Receptor Polymorphisms With Antipsychotic
Drug Response in Schizophrenia
Jiang Li*, Herbert Meltzer, Hitoshi Hashimoto
268
11/10/15 9:58 AM
W176.Structural Imaging Patterns Linked to 12q24
Vince Calhoun*, Emma Sprooten, Cota Navin Gupta, Emma
Knowles, Reese McKay, Samuel R. Mathias, Joanne E. Curran, Jack
W. Kent Jr., Melanie A. Carless, Thomas Dyer, Harald H.H. Göring,
Rene L. Olvera, Peter Kochunov, Peter T. Fox, Laura Almasy, Ravi
Duggirala, John Blangero, Jessica Turner, David Glahn
W177.Is Increased Glutamate in the Associative Striatum a Reliable Biomarker
in Antipsychotic-Naïve First-Episode Psychosis Patients?
Camilo de la Fuente-Sandoval*, Eric Plitman, Francisco ReyesMadrigal, Sofia Chavez, Gladys Gómez-Cruz, Pablo León-Ortiz,
Ariel Graff-Guerrero
W178.Development of a Discrete Trials Task to Assess Serotonergic
Modulation on Interval Timing in Mice
Adam Halberstadt*, Ivan Sindhunata, Mark Geyer, Jared Young
W179.Altered Insula Between-Network Connectivity in Schizophrenia
Jason Tregellas*, Korey Wylie, Jason Smucny, Ann Olincy, Kristina
Legget
W180.Deficits in Working Memory Performance in Schizophrenia are
Associated With the Absence of an Inverted-U Relationship Between
Dorsolateral Prefrontal Cortex Activation and Working Memory Load
Jared Van Snellenberg*, Ragy Girgis, Guillermo Horga, Elsmarieke
van de Giessen, Mark Slifstein, Najate Ojeil, Holly Moore, Edward
Smith, Daphna Shohamy, Jeffrey Lieberman, Anissa Abi-Dargham
W181.Activation of D2R Elicits Structural Changes in Human Neuronal-Like
Cells Transdifferentiated From Blood Circulating Monocytes
Adam Lescalette, Michael Valente, Julien Matricon, R. Gardette,
Sean Seung-Kwon, Therese Jay, Marie-Odile Krebs, Anne Hosmalin,
Vincent Feuillet, Alfredo Bellon*
269
11/10/15 9:58 AM
W182.Imaging Translocator Protein (TSPO) in Subjects at High Risk of
Psychosis and in Schizophrenia: An [11C] PBR28 PET Brain Imaging
Study
Sudhakar Selvaraj*, Peter Bloomfield, Mattia Veronese, Gaia
Rizzo, Alessandra Bertoldo, David Owen, Michael Bloomfield,
Ilaria Bonoldi, Nicola Kalk, Federico Turkheimer, Philip Mcguire,
Vincenzo de Paola, Oliver Howes
W183.A Critical Role for the Transcription Factor Estrogen-Related ReceptorGamma in the Regulation of Gene Expression and Function of
Parvalbumin-Positive Neurons
Rita M. Cowell*, Andrew S. Bohannon, Briana M. Watkins, Allison
K. Dahlberg, Ashruta Patel, Aundrea F. Bartley, Jeremy J. Day, Lynn
E. Dobrunz, John J. Hablitz, Laura J. McMeekin
W184.A Randomized Comparison of Aripiprazole and Risperidone for the
Acute Treatment of First-Episode Schizophrenia and Related Disorders:
3 Month Outcomes
Delbert Robinson, Juan Gallego*, Majnu John, Georgios Petrides,
Youssef Hassoun, Jianping Zhang, Leonardo Lopez, Raphael Braga,
Serge Sevy, Jean Addington, Charles Kellner, Mauricio Tohen,
Melissa Naraine, Natasha Bennett, Jessica Greenberg, Todd Lencz,
Christoph Correll, John Kane, Anil Malhotra
W185.Role of Mitochondrial Uncoupling Proteins in Behavioral and
Biochemical Phenotypes of Mental Illness
Gretchen Hermes*, David Nagy, Mihaly Hajos, Tamas Horvath
W186.Dissection of the Auditory Steady State Response by Continuous WideSpectrum Rhythmic Stimulation at Varying Intensity Levels
Nicola Riccardo Polizzotto*, Christopher Walker, Nithya
Ramakrishnan, Cristin Rodriguez, Raymond Cho
W187.Disrupting Function of Gaba Neurons With a Modified Diphtheria Toxin
Susan Powell*, Sorana Caldwell, Daniel Knowland, Xianjin Zhou
270
11/10/15 9:58 AM
W188.Differential Impact of Peripheral Inflammatory Mediators on Neuropil
Synthesis and Pruning in Schizophrenia: Clinical and Neurocognitive
Implications
Konasale Prasad*, Ashley Burgess, Matcheri Keshavan, Vishwajit L.
Nimgaonkar, Jeffrey Stanley
W189.Predictors of Functional Outcome and Transition to Psychosis Across
the ARMS Category: A Longitudinal Comparison Study on Predictors
of Functional Outcome and Transition to Psychosis in Ultra High Risk
(UHR) and Non-UHR Young Patients With Comparable Axis I and II
Diagnoses
Amedeo Minichino*, Marta Francesconi, Kristin Cadenhead, Arturo
Bevilaqua, Maurizio Parisi, Santo Rullo, Francesco Saverio Bersani,
Massimo Biondi, Roberto Delle Chiaie
W190.Metabolic Abnormalities Prior to the Onset of Psychosis: Another Risk
Factor for Psychosis?
Kristin Cadenhead*, Jean Addington, Carrie Bearden, Ty Cannon,
Barbara Cornblatt, Daniel Mathalon, Thomas McGlashan, Diana
Perkins, Larry Seidman, Elaine Walker, Scott Woods
W191. Chondroitin Sulfate Proteoglycan Abnormalities Are Associated With
Altered Thalamic Axonal Pathways in Schizophrenia
Harry Pantazopoulos*, Lilla Turiak, Oliver King, Joseph Zaia,
Sabina Berretta
W192.Association Network Disruption in Psychotic Disorders: Effects of
Diagnosis, Symptoms, and Network Dynamics
Justin Baker*, Grace Masters, Matthew Hutchison, Caitlyn
Ravichandran, Randy Buckner, Bruce M. Cohen, Dost Ongur
W193.Effect of DISC1 Gene Structural Variants on Cognitive Potentials and
Gamma Activity
Vincenzo De Luca*, Gustavo Franca Morales, Ziluk Angela, Ali
Bani Fatemi, Zafiris Daskalakis
271
11/10/15 9:58 AM
W194.Comparing DTI White Matter Integrity to Labeled Fiber Tracts in
CLARITY Whole-Brains
Eric Chang*, Miklos Argyelan, Toni-Shay Chandon, Jordan
Dienstag, Yifan Li, Manisha Aggarwal, Susumu Mori, Anil Malhotra
W195.Tryptophan Degradation and White Matter Structure in Schizophrenia
Joshua Chiappelli*, Laura Rowland, Andrea Wijtenburg, Qiaoyun
Shi, Priyadurga Kodi, Christopher Gaudiot, Susan Wright, Peter
Kochunov, Dietmar Fuchs, Adem Can, Teodor Postolache, Elliot
Hong
W196.Conditional Rescue of NMDA Receptor Hypofunction to Study the
Plasticity and Circuitry of Schizophrenia-Relevant Behaviours
Catharine Mielnik, Marie Kristel Bermejo, Rehnuma Islam, Marija
Milenkovic, Wendy Horsfall, Ali Salahpour, Amy Ramsey*
W197.Association of Neuroanatomical Structures Mediating Episodic Memory
Impairment and Resting State Functional Connectivity in Early-Phase
Psychosis
Michael Francis*, Tom Hummer, Jenifer Vohs, Nikki Mehdiyoun,
Emily Liffick, Matthew Yung, Alan Breier
W198.Mismatch Negativity and Repetition Positivity Deficits Implicate
Deficient Predictive Coding in the Auditory System in Clinical High
Risk Youth who Transition to Psychosis
Daniel Mathalon*, Jean Addington, Peter Bachman, Aysenil
Belger, Kristin Cadenhead, Ty Cannon, Ricardo Carrion, Barbara
Cornblatt, Erica Duncan, Jason Johannesen, Gregory Light, Thomas
McGlashan, Margaret Niznikiewicz, Diana Perkins, Larry Seidman,
Ming Tsuang, Elaine Walker, Scott Woods
W199.Discovery of Novel Inhibitors of D-Amino Acid Oxidase
Guochuan Tsai*
272
11/10/15 9:58 AM
W200.Development and Validation of a Laser Capture Microdissection Targeted Mass Spectrometry Approach for Cortical Layer Specific
Protein Quantification in Postmortem Human Brain Tissue
Matthew MacDonald*, Dominique Arion, Daly Favo, Nathan Yates,
David Lewis, Robert Sweet
W201.Whole Genome Sequencing in a Founder Population Identifies Novel
Candidate Rare Variants for Schizophrenia
Todd Lencz*, Jin Yu, Anil Malhotra, Itsik Pe’er, Ariel Darvasi
W202.Disrupted Functional Connectivity of Auditory Cortex in Psychotic
Bipolar Disorder Patients With Lifetime Auditory Hallucinations
Ann K. Shinn*, Jessica Talero, Youkyung Sophie Roh, Grace A.
Masters, Bruce M. Cohen, Justin T. Baker, Dost Ongur
W203.Dopamine D4 Agonist Restores Novel Object Recognition in SubChronic Phencyclidine-Treated Rats
Masanori Miyauchi*, Nichole Neugebauer, Herbert Meltzer
W204.Interleukin-1β Alters Cortical Connectivity and Mediates the Effects
of Maternal Immune Activation Through Dynamic Changes in IL-1β
Receptor Localization and MHCI Signaling
Myka Estes, A. Kimberley McAllister*
W205.Development of a Platform Agnostic Software Engine to Facilitate
Widespread Adoption of Cognitive Remediation Therapy in
Schizophrenia
Brent Nelson*, Elias Boroda, Jazmin Camchong, Suzanne Jasberg,
Kelvin Lim
W206.Preliminary Longitudinal Study Examining the Clinical Correlates of
Medication Adherence Assessed via a Mobile Health Application in
Early Psychosis Care
Tara Niendam*, Ana-Maria Iosif, Laura M. Tully, Kathleen Burch,
Cameron Carter
273
11/10/15 9:59 AM
W207.Functional Imaging of Working Memory, Episodic Memory, and Social
Stress
Hao Yan*, Guang Yang, Xiao Zhang, Zheng Dong, Debjani Saha,
Yina Ma, Qiang Chen, Venkata Mattay, Weihua Yue, Daniel
Weinberger, Dai Zhang, Hao Yang Tan
W208.Polysomnographic Characterization of Nocturnal Sleep in Cynomolgus
Macaques
Anushka Goonawardena, Massimiliano de Zambotti, Adrian
Willoughby, Courtney Glavis-Bloom, Ian Colrain, Tanya Wallace,
Thomas Kilduff*
W209.Jumping the Gun: Mapping a Translational Network in Waiting
Impulsivity
Valerie Voon*, Laurel Morris, Prantik Kundu, Mircea Polosan, Paul
Krack, Jon Grant, Trevor Robbins, Edward Bullmore
W210.Cocaine-Induced Neuroplasticity Depends on Behavioral Responding to
a Natural Reward
Bernadette O’Donovan*, Haley Andersen, Pavel Ortinski
W211.Imaging CA1-Hippocampal Neuronal Ensembles During NicotineDependent Contextual Associations
Li Xia, Stephanie Nygard, Ben Acland, Nick Hourguettes, Gabe
Sobczak, Michael Bruchas*
W212.Phasic Dopamine Release Elicited by Unexpected Presentation of DrugPaired Cues Increases With Protracted Drug-Access
Lauren Burgeno*, Nicole Murray, Ingo Willuhn, Paul Phillips
W213.Neuroepigenetic Regulation by Extra-Coding RNA
Katherine Savell, Nancy Gallus, David Sweatt, Jeremy Day*
W214.Recruitment of a CRF-Regulated Dopaminergic Projection From the
VTA to the Prelimbic Cortex Results in Heightened Susceptibility to
Stress-Induced Relapse
Oliver Vranjkovic, Jordan Blacktop, Audrey Seasholtz, John
Mantsch*
274
11/10/15 9:59 AM
W215.Reasons for Change in Alcohol Drinking Behaviors in a Native
American Community Sample
David Gilder*, Linda Corey, Cindy Ehlers
W216.Altered Neural Processing to Social Exclusion in Young Adult Marijuana
Users
Jodi Gilman*, Randi Schuster, Anne Eden Evins
W217.Mesocortical Dopamine Encodes Cocaine Cues After Chronic Cocaine
Self-Administration via Enduring Inhibition of Kv7 Channels
William Buchta*, Stephen Mahler, Gary Aston-Jones, Art Riegel
W218.Effects of DRD4 VNTR Genotype on Alcohol Cue-Elicited Brain
Activation Among Treatment-Seeking Alcoholics
Joseph Schacht*, Hugh Myrick, Patricia Latham, Konstantin
Voronin, Raymond Anton
W219.Sex-Differences in Grey Matter Volume in Cocaine Use Disorder: A
Voxel-Based Morphometric Study
Rebecca Preston-Campbell*, Gabriela Gan, Anna Zilverstand, Scott
Moeller, Muhammad Parvaz, Nelly Alia-Klein, Rita Goldstein
W220.Alterations of Glial Glutamate Transporters and Certain
Neurotransmitters in Alcohol Withdrawal Syndrome Using Alcohol
Preferring Rat Model
Youssef Sari*, Sujan Das
W221.Tolerance to Alcohol-Stimulated GluR1 Phosphorylation in the Central
Amygdala in the Context of Nicotine Dependence
Adrienne McGinn, Muhammad Farooq, Jonathan Reppel, Nicholas
Gilpin, Scott Edwards*
W222.Resting State Functional Connectivity in Rat Brain During Extended
Daily Access to Cocaine and Abstinence
Marcelo Febo*, Caitlin Orsini, Luis Colon-Perez, Sara Heshmati,
Lori Knackstedt, Barry Setlow
275
11/10/15 9:59 AM
W223.Withdrawn
W224.Intravenous and Smoked Methamphetamine in Women – “It’s Like Two
Different Drugs”
Nicholas Goeders*
W225.Development of a Novel Rodent Model of THC Self-Administration
Sade Spencer*, Danielle Schwartz, Nicholas Allen, Vivian Chioma,
Peter Kalivas
W226.Lower Brain Responses During Cognitive Inhibition of Food Craving
Elicited by Food Stimulation in Obese Subjects
Gene-Jack Wang*, Ehsan Shokri Kojori, Dardo Tomasi, Christopher
Wong, Nora Volkow
W227.Rapid Changes in CB1 Receptor Availability in Cannabis Dependent
Males After Abstinence From Cannabis
Deepak D’Souza*, Jose Cortes-Briones, Mohini Ranganathan, Halle
Thurnauer, Gina Creatura, Toral Surti, Beata Planeta, Brian Pittman,
Alexander Neumeister, Yiyun Huang, Richard Carson, Patrick
Skosnik
W228.Cocaine Mediated Molecular Regulation of Mitochondrial Dynamics in
Nucleus Accumbens Projection Neuron Subtypes
Ramesh Chandra, Michel Engeln, Lace Riggs, T. Chase Francis,
Jeremy Winer, Airunzaya Amgalan, Leah Jensen, Prasad
Konkalmatt, Amy Gancarz, Sam Golden, Gustavo Turecki, Scott
Russo, Sergio Iniguez, David Dietz, Mary Kay Lobo*
W229.Ecological Momentary Assessments and Attentional Bias Modification
for Postpartum Smoking
Ariadna Forray*, Andrew Waters
276
11/10/15 9:59 AM
W230.The Relationship Between Pain and Prescription Drug Use Disorders: A
National Prospective Study
Carlos Blanco*, Melanie Wall, Mark Olfson
W231.Role of TAAR1 in the Mesolimbic Regions in Cocaine-Seeking
Behavior
Jianfeng Liu, Yanan Zhang, Jun-Xu Li*
W232.Prescription Opiate Dependent Patients Display Anhedonia and
Differential Processing of Reward Stimuli Following Withdrawal: An
fNIR Study
Andrew Huhn, Roger Meyer*, Dean Stankoski, Jonathan Harris,
Edward Bixler, Scott Bunce
W233.Telomere Length in Crack/Cocaine Use Disorder With Early Life Stress
Mateus Levandowski*, Saulo Tractenberg, Lucas Rizzo, Pawan
Maurya, Elisa Brietzke, Tatiana De Nardi, Andrea Wieck, Rodrigo
Grassi-Oliveira
W234.Calcium Permeable AMPA Receptors Mediate Synaptic Plasticity
at Synapses Onto Nucleus Accumbens Parvalbumin Expressing
Interneurons
Dipanwita Ghose, Brad Grueter*
W235.Acute Effects of Alcohol and Nicotine on Perfusion and Functional
Connectivity in Reward and Cognitive-Control Brain Circuitry
Lisa Nickerson*, Manus Donahue, Blaise Frederick, Dave Penetar,
Scott Lukas
W236.The 5-HT7 is Potential Target for the Suppression of Alcohol Craving:
Modulation of Context and Cue-Induced Alcohol Seeking Behaviors
Sheketha Hauser*, Gerald Deehan Jr, Christopher Knight, William
McBride, Zachary Rodd
W237.Adolescent Alcohol Exposure and Persistent Effects on LSD1-Mediated
Chromatin and Synaptic Remodeling in the Amygdala
Subhash Pandey*, Evan Kyzar, Amul Sakharkar, Huaibo Zhang
277
11/10/15 9:59 AM
W238.Gene X Smoking Interactions in the Ventromedial PFC: Alpha 5
Nicotinic Cholinergic Receptor Gene Variation and Smoking Effects on
Adolescent Grey Matter
Bader Chaarani, Scott Mackey, Phil Spechler, Stephen Higgins,
Alexandra Potter, Robert Althoff, Elliot Stein*, Hugh Garavan,
IMAGEN Consortium
W239.Effects of Chronic Alcohol Drinking on Circadian Gene Expression
Angela Ozburn*
W240.Chronic Stress Exposure During Early Withdrawal Enhances Incubation
of Cocaine Craving
Jessica Loweth*, Ryan Glynn, J. A. Rosenkranz, Marina Wolf
W241.Sex Differences of Insula Volume in Cannabis Dependence and
Association With Cognition and Emotion
Meina Quan*, Lisa Nickerson
W242.5-HT1B Receptor Agonism has Different Effects on Cocaine-Induced
Locomotion and Dopamine Neuron Activity in the VTA Depending on
Time of Testing After a Repeated Injection Regimen in Mice
Janet Neisewander*, Ming Gao, Taleen Der-Ghazarian, Jie Wu
W243.Nuclear HDAC5 Suppresses Cocaine Reward-Like Behaviors Through
Repression of its Target Gene, Npas4, in the Nucleus Accumbens
Makoto Taniguchi*, Maria Carreira, Yonatan Cooper, Evan Balmuth,
Jaswinder Kumar, Laura Smith, Nobuya Koike, David Self, TaeKyung Kim, Joseph Takahashi, Yingxi Lin, Christopher Cowan
W244.Psychosocial Stress and Consumption of a High Calorie Diet in Female
Monkeys Alters Brain Neurochemistry and Functional Connectivity: A
Model of Food Addiction?
Vasiliki Michopoulos*, Jodi Godfrey, Maylen Perez Diaz,
Venkatagiri Krishnamurthy, Zsofia Kovacs, Melanie Pincus, Mar
Sanchez, Mark Wilson
278
11/10/15 9:59 AM
W245.Dysregulated NMDA NR1 Signaling in the Infralimbic Cortex
Contributes to Increased Impulsivity During Protracted Alcohol
Abstinence
Cristina Irimia, Matthew Buczynski, Sarah Laredo, Nathaniel
Alvaros, Loren Parsons*
W246.Novel Treatments for Cocaine Bingeing and Relapse: Progesterone and
Exercise
Marilyn Carroll*, Natalie Zlebnik, Jack Smethells, Natashia Swalve
W247.Social Economic Status Predicts Dopamine D2/3 Receptor Availability
in Healthy Volunteers but Not Cocaine Abusers
Corinde E. Wiers*, Ehsan Shokri-Kojori, Elizabeth Cabrera,
Samantha Cunningham, Dardo Tomasi, Gene-Jack Wang, Nora D.
Volkow
W248.“Too Much of a Good Thing?” A Heightened Brain Response to 6
Second Cocaine Video Cues Predicts Poor Drug Use Outcomes
Anna Rose Childress*, Kanchana Jagannathan, Paul Regier, Zach
Monge, Teresa Franklin, Jesse Suh, Reagan Wetherill, Kimberly
Young, Daniel Langleben, Ronald Ehrman, Ze Wang, Michael
Gawrysiak, Charles O’Brien
W249.Homer2 Regulates Sensitivity to Methamphetamine Reward
Chelsea Brown, Sema Quadir, Daniel Flaherty, Karen Szumlinski*
W250.Essential Role for Arc in Cocaine Addiction-Related Behaviors and
Synapse Plasticity
Laura Smith*, Rachel Penrod, Jaswinder Kumar, Jakub Jedynak,
Morgane Thomsen, Makoto Taniguchi, Christopher Cowan
W251.Sign-Tracking is More Resistant to Extinction Than Goal-Tracking, but
More Sensitive to Spontaneous Recovery
Christopher Fitzpatrick, Justin Creeden, Jonathan Morrow*
279
11/10/15 9:59 AM
W252.Transcriptional Profiling and Behavioral Phenotyping of Cell
Populations in the Mouse Interpeduncular Nucleus During Nicotine
Exposure
Jessica Ables*, Andreas Gorlich, Beatriz Antolin Fontes, Cuidong
Wang, Awni Mousa, Ines Ibanez-Tallon
W253.Ibudilast, a Novel Neuroimmune Modulator, Decreases Alcohol Craving
and Increases Positive Mood in an AUD Population
Daniel Roche*, Spencer Bujarski, Lara Ray
W254.Epigenetic Regulation of Memory System Competition Following
Withdrawal From Cocaine
Eric Harvey, Jesus Ochoa, Pamela Kennedy*
W255.Discerning the Contribution of Negative Affective-Like and Somatic
Symptoms of Withdrawal to the Etiology of Escalated Alcohol SelfAdministration in Alcohol Dependence: Role of Nucleus Accumbens
Shell Kappa-Opioid Receptors
Angela Williams, Rachel Abella, Jessica Kissler, Chloe Erikson,
Brendan Walker*
W257.Dependence of Nucleus Accumbens Shell Dialysate Dopamine From
the Activity of Apamin-Sensitive Slow-Conducting Ca2+-Activated K+
Channels
Gaetano Di Chiara*, Cristina Miliano, Valentina Valentini, Giovanna
Piras
W258.The Interaction of Food Intake With Voluntary Alcohol Intake: Effects
of Macronutrient Deprivation, Incentive Motivation, and Galanin
Microinjection
Michael Lewis*, Michal Atram, Jun-Qi Zheng
W259.Acute Responses to Marijuana: Effects of a Strain High in Cannabidiol
Kent Hutchison*, Angela Bryan
280
11/10/15 9:59 AM
W260.Imaging the Effect of Deep rTMS on Brain Activity in Chronic Cannabis
Use
Nina Urban*, Diana Martinez, Zhishun Wang, Grassetti Alex, Wang
Dinnisa, Haney Margaret
W261.The Effect of Oxytocin on Methylphenidate-Induced Stimulation of
Dopamine Levels: Importance of Route of Administration for Oxytocin
Mary R. Lee*, Matthew C.H. Rohn, Gianluigi Tanda, Amy H.
Newman, Lorenzo Leggio
W262.Arithmetic and Local Circuitry Underlying Dopamine Prediction Errors
Neir Eshel*, Michael Bukwich, Vinod Rao, Vivian Hemmelder, Ju
Tian, Naoshige Uchida
281
11/10/15 9:59 AM
Notes
282
11/10/15 9:59 AM
Explanation of Conflict of Interest Disclosure Parts:
Part One: All Financial Involvement with a pharmaceutical or biotechnology company, a
company providing clinical assessment, scientific, or medical companies doing business with or
proposing to do business with ACNP over past 2 years (Jan. 2013-Present)
Part Two: Income Sources & Equity of $10,000 or greater
Part Three: Financial Involvement with a pharmaceutical or biotechnology company, a
company providing clinical assessment, scientific, or medical products or companies doing
business with or proposing to do business with ACNP which constitutes more than 5% of
personal income (Jan. 2013-Present):
Part Four: Grants from pharmaceutical or biotechnology company, a company providing
clinical assessment, scientific, or medical products directly, or indirectly through a foundation,
university, or any other organization (Jan. 2013-Present)
Part Five: My primary employer is a pharmaceutical/biotech/medical device company.
2015 Program Committee Disclosures
Adler, Caleb: Part 1: Merck (speaker and grant recipient), Forest (grant recipient), Sunovion
(speaker), AstraZeneca (grant recipient), Part 2: Sunovion (speaker, 2013 only), Part 4: Merck
(transferred to Forest this year). The grant is to the UC practice corporation but is for my
research. AstraZeneca. Received the final payment for a grant in 2013. The grant was to the UC
practice corporation but was for my research.
Andrews, Anne: Part 1: Forest Labs -- consultant, Part 2: Forest Labs, Part 3: Forest Labs.
Davidson, Michael: Part 1: Clinirx Tangent Research, Minerva Neuroscience, Part 2: Clinirx
Tangent Research, Minerva Neuroscience, Part 4: Stanley MEdical Research.
DelBello, Melissa: Part 1: Research Support: Eli Lilly, GlaxoSmithKline, Merck, Martek,
Novartis, Lundbeck, Shire, Purdue, Amylin, Sunovion, Pfizer, Lecture Bureau: Otsuka, BristolMyers Squibb, Consulting/Advisory Board/Honoraria/Travel: Pfizer, Dey, Lundbeck, Sunovion,
Otsuka, Supernus, Part 2: Otsuka, Part 4: Research Support: Eli Lilly, GlaxoSmithKline,
Merck, Martek, Novartis, Lundbeck, Shire, Purdue, Amylin, Sunovion, Pfizer.
Deutch, Ariel: Part 1: Eli Lilly & Co.
Dougherty, Darin: Part 1: Medtronic—honoraria, Roche--travel expenses, J & J—honoraria,
Insys--research support, Part 4: Medtronic--research support, Cyberonics--research support, Eli
Lilly--research support, Roche--research support.
Goldstein, Rita: Part 2: Icahn School of Medicine at Mount Sinai.
Greene, Robert: Part 5: University of Texas Southwestern.
Innis, Robert: Part 4: Eli Lilly, J&J, for both companies, I am PI on a research grant performed
at NIH.
Law, Amanda: Part 1: Dr. Law serves as a paid consultant for Astra Zeneca Pharmaceuticals.
Malhotra, Anil: Part 1: Genomind, Inc.—consultant, Forum Pharma.—consultant.
Marder, Stephen: Part 1: Abbvie, Lundbeck, Roche, MedAvante, Genentech, Pfizer, Forum,
Targacept, Otsuka, Takeda, Boeringer-Ingelheim, Merck, Part 4: Amgen, Sunovion, Neurocine,
Psychogenics, Synchroneuron.
283
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2015 Program Committee Disclosures (continued)
Mason, Barbara: Part 1: Depomed, consultant.
Mathalon, Daniel: Part 1: Consultant to Hoffman-La Roche AG.
McClung, Colleen: Part 1: Autifony Limited- research funding, Johnson & Johnson- research
funding, Orphagen pharmaceuticals- paid consultant, Part 4: Autifony Limited, Johnson &
Johnson.
Merchant, Kalpana: Part 1: Employee of Eli Lilly and Company until March 12, 2014;
Shareholder of Eli Lilly and Company; President of TransThera Consulting Co.; Member of
Scientific Advisory Board for Lysosomal Therapeutics, Siragen; Advisor to Life Sciences
Venture companies and Michael J Fox Foundation for Parkinson’s Research, Part 2: Eli Lilly
and Company; TransThera Consulting Co., Part 3: Employee of Eli Lilly and Company
until March 2014; President of TransThera Consulting Co., Part 5: President of TransThera
Consulting Co.
Phillips, Paul: Part 1: My spouse is an employee of Amgen Inc., and we own stock in
that company., Part 2: My spouse is an employee of Amgen Inc., and we own stock in that
company., Part 3: My spouse is an employee of Amgen Inc., and we own stock in that
company., Part 5: My spouse is a Principle Scientist at Amgen Inc.
Russo, Scott: Part 1: I serve as a paid consultant for Johnson and Johnson. I received a research
grant from Johnson and Johnson, Part 4: Johnson and Johnson, Part 5: Icahn School of
Medicine at Mount Sinai.
Schulze, Thomas G.: Part 1: Roche Pharmaceuticals, Advisory Board & research grant, Part 4:
Roche Pharmaceuticals.
Veenstra-VanderWeele, Jeremy: Part 1: Consulting: Roche, Novartis, SynapDx. Research
funding: Roche, Novartis, SynapDx, Seaside Therapeutics, Sunovion, Forest. Editorial:
Springer, Wiley, Part 4: Research funding: Roche, Novartis, SynapDx, Seaside Therapeutics,
Sunovion and Forest. Editorial: Springer, Wiley.
Zarate, Carlos: Part 1: Dr Zarate is listed as a co-inventor on a patent application for the use of
ketamine and its metabolites in major depression. Dr Zarate has assigned his rights in the patent
to the US government but will share a percentage of any royalties that may be received by the
government.
Program Committee members with nothing to disclose:
Ajilore, Olusola
Ehlers, Cindy
Andersen, Susan
Enoch, Mary-Anne
Aston-Jones, Gary
Han, Ming-Hu
Bolanos-Guzman, Carlos
Karlsgodt, Katherine
Bruno, John
Lee, Francis
Corcoran, Cheryl
Martinowich, Keri
DeRosse, Pamela
Moghaddam, Bita
Deutsch, Stephen
Phillips, Mary
Dulawa, Stephanie
Rao, Uma
284
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2015 Presenter Disclosures
Anton, Raymond: Part 1: I chair the ACTiVE workgroup affiliated by the ASCP which is
supported by Lilly, Lundbeck. Abbvie, Pfizer, Ethylpharm. In the last year I received grant funds
from Lilly and have been a paid consultant for Novartis., Part 4: Lilly.
Beasley, Charles: Part 1: Eli Lilly, Part 2:Eli Lilly, Part 3: Ei Lilly, Part 5: Eli Lilly (retired).
Bespalov, Anton: Part 1: AbbVie, Part 2:AbbVie, Part 5: AbbVie.
Bogenschutz, Michael: Part 4: Research grant for a non-pharmacologic treatment study from
the Lundbeck Foundation, through the University of Southern Denmark.
Bohn, Laura: Part 1: A patent has been filed by TSRI on this work., Part 4: Funding from Eli
Lilly in Company, not on the work presented here.
Bunce, Scott: Part 1: Dr. Bunce owns stock in FNIR Devices, LLC., a company that
manufactures and sells fNIR devices for research.
Caron, Marc: Part 1: MGC has received compensation from Lundbeck as a member of their
Psychopharmacology Advisory Board and is a consultant for Omeros Corp. MGC also owns
equity in Acadia Pharmaceuticals., Part 2:Acadia Pharmacceuticals.
Chang, Kiki: Part 1: Consultant for Sunovion, Actavis, Merck, GSK, Part 4: GSK, Merck.
Comer, Sandra: Part 1: AstraZeneca, Camarus, Janssen, Mallinkcrodt, Medicinova,
Omeros, Pfizer, Reckitt Benckiser, Salix, Shire, Part 2:Reckitt Benckiser, Reckitt Benckiser
(investigator-initiated research grant).
Coyle, Joseph: Part 1: Consultant to Abbvie, Novartis, Forum Pharm.
DelBello, Melissa: Part 1: Pfizer, Lundbeck, Sunovian, Otsuka, Supernus, Forest, Actavis, Part
4: Eli Lilly, Otsuka, GlaxoSmithKline, Merck, Martek, Novartis, Lundbeck, Shire, Purdue,
Amylin, Sunovion, Pfizer.
Denys, Damiaan: Part 1: I am a member of the advisory board of Lundbeck. I receive
occasional fees from Medtronic for educational purposes., Part 4: I have received an
unrestricted investigator-initiated research grant by Medtronic Inc.
Dolmetsch, Ricardo: Part 1: Novartis Institutes for Biomedical Research, Part 5: Novartis
Drevets, Wayne: Part 1: Johnson & Johnson, Inc., Use Patent filed “Composition and Method
for Treating Bipolar Disorder”, Use Patent awarded, “Scopolamine in the Treatment of
Depression” (no financial proceeds to date), Part 2:Johnson & Johnson, Inc., Equity and Salary,
Part 3: Johnson & Johnson, Inc., Part 5: Johnson & Johnson, Inc.
Evins, Anne: Part 1: Payment to my institution by Pfizer Inc, Reckett Benckizer, and Forum
Pharmaceuticals, Part 4: Research grants to my institution from Pfizer and Forum.
Geyer, Mark: Part 1: Lundbeck, Omeros, Otsuka, San Diego Instruments, and Sunovion,
Part 2:Omeros Pharma; Otsuka Pharma; San Diego Instruments, Part 4: Spouse (A. Markou):
Forrest Labs; AstraZeneca.
285
11/10/15 9:59 AM
2015 Presenter Disclosures (continued)
Gold, Lisa: Part 1: Full time employee of Merck & Co, Part 2:Full time employee of Merck
and Co, Part 3: Full time employee of Merck & Co, Part 5: Merck & Co.
Goodman, Wayne: Part 4: Medtronic donated devices for study of Lateral Habenula DBS in
TRD.
Green, Alan: Part 1: Support for research from: Novartis. Uncompensated consultant to:
Otsuka, Alkermes. Member of Data Monitoring Board: Eli Lilly, Part 4: Support for research
from Novartis.
Green, Michael: Part 1: Dr. Green has been a paid consultant for AbbVie, DSP, Forum, and
Takeda, and a member of the Scientific Board of Mnemosyne., Part 4: Dr. Green has received
research funds from Amgen and Forum.
Griffiths, Roland: Part 1: I am a consultant to Merck and Co and Jazz Pharmaceuticals. I am
on the Board of Directors of the Heffter Research Institute., Part 4: Heftier Research Institute
has provided grant funding of some of my research.
Gur, Raquel: Part 1: Served on Advisory Board for Otsuka 2013/14.
Halberstadt, Adam: Part 1: L-3 Communications; Roche., Part 4: Roche.
Heckers, Stephan: Part 1: Editor stipend (JAMA Psychiatry) from American Medical
Association.
Holtzheimer, Paul: Part 1: Consultant, St. Jude Medical Neuromodulation (testing a DBS
device for depression), Part 4: Cervel Neurotech (TMS manufacturer).
Hong, Elliot: Part 1: Dr. Hong has been a Consultant/Advisor to Pfizer, Part 4: Dr. Hong has
received research grants from Mitsubishi Pharma, Pfizer, and Your Energy Systems, LLC.
Howes, Oliver: Part 1: Dr Howes has received investigator-initiated research funding from
and/or participated in advisory/ speaker meetings organised by Astra-Zeneca, BMS, Eli Lilly,
Jansenn, Lundbeck, Lyden-Delta, Otsuka, Servier, and Roche. Neither Dr Howes or his
family hav, Part 4: Dr Howes has received investigator-initiated research funding from and/or
participated in advisory/ speaker meetings organised by Astra-Zeneca, BMS, Eli Lilly, Jansenn,
Lundbeck, Lyden-Delta, Otsuka, Servier, and Roche. Neither Dr Howes or his family have been
employed by or have holdings/ a financial stake in any biomedical company.
Hyman, Steven: Part 1: Novartis (SAB), AstraZeneca iMed Neuro (SAB) Ended 2014,
Suniovion (SAB), Part 2:Novartis.
Ivanov, Iliyan: Part 1: DSMB member for Lundbeck – honoraria.
Javitt, Daniel: Part 1: Omeros; SKBP; Otsuka; Sunovion; Lundbeck; Forum/Envivo; Takeda;
Glytech, Inc., Part 2:Glytech, Inc., Part 4: Roche
Karp, Jordan: Part 4: Provision of medication supplies for investigator initiated trials from
Pfizer and Reckitt Benckiser.
286
11/10/15 9:59 AM
Knickmeyer, Rebecca: Part 1: I am co-investigator on a grant supported by Pfizer., Part 4: I
am co-investigator on a grant supported by Pfizer. I do not receive any salary support.
Kranzler, Henry: Part 1: Advisory board member or consultant for Alkermes, Lilly, Lundbeck,
and Otsuka and member of the American Society of Clinical Psychopharmacology’s Alcohol
Clinical Trials Initiative, which is supported by AbbVie, Alkermes, Ethypharm, Lilly, Lundbeck,
and Pfizer.
Law, Amanda: Part 1: Dr. Law has served as a paid consultant for Astra Zeneca
Pharmaceuticals.
Leggio, Lorenzo: Part 2:Dr. Leggio serves as Editor for Alcohol and Alcoholism, a Journal
jointly owned by Oxford University Press and the Medical Council on Alcohol, London, UK.
Lovenberg, Timothy: Part 1: I am an employee of a pharmaceutical company, Part 5: Janssen
Pharmaceutical R&D. LLC.
Mason, Barbara: Part 1: Depomed.
Matsumoto, Mickey: Part 1: I am a full-time employee of Astellas Pharma Inc., Part 5:
Astellas Pharma Inc.
Mayberg, Helen: Part 1: Consultant, licensing of IP to St Jude medical, Inc (neuromodulation),
Part 2:licensing of IP to St Jude Medical, Inc (neuromodulation), Part 4: Medtronic and St Jude
Medical Inc (donation of unapproved devices).
Meyer, Jeffrey: Part 1: Drs. Meyer has received operating grant funds for other studies from
Janssen, Eli-Lilly, GlaxoSmithKline, Bristol Myers Squibb, Lundbeck, and SK Life Sciences in
the past 5 years. Dr. Meyer has consulted to several of these companies, as well as Takeda, S,
Part 2:It is possible that the total amount from Trius or Teva could have reached $10000., Part
4: Janssen.
Mischoulon, David: Part 1: Dr Mischoulon has received royalties from Lippincott Williams
& Wilkins for published book “Natural Medications for Psychiatric Disorders: Considering the
Alternatives.”, Part 4: Dr Mischoulon has received research support through grants from the
Bowman Family Foundation, FisherWallace, Nordic Naturals, Methylation Sciences, Inc. (MSI),
and PharmoRx Therapeutics.
Nishikawa, Toru: Part 1: The authors declare no conflict of interest related to the subject of this
presentation. Dr. Nishikawa was recently compensated for is lectures by Astllas, MSD, Eli Lilly,
GSK and Otsuka pharmaceutical industries and for his consultancy by Mochida Pharma, Part
4: As shown in a part of the above “Disclosure Part 1”, Dr. Toru Nishikawa received grants for
scientific research, but not for clinical drug assessment, from Tanabe-Mitsubishi, MSD, Pfizer,
Astllas, Otsuka and Shionogi pharmaceutical industries directly.
Oquendo, Maria: Part 1: Family owns stock in Bristol Myers Squibb., Part 2:Royalties for the
commercial use of the C-SSRS., Part 3: Family owns stock in Bristol Myers Squibb., Part 5:
Spouse works for BMS.
Phillips, Mary: Part 1: I am a consultant for Roche Pharmaceuticals.
287
11/10/15 9:59 AM
Phillips, Paul: Part 1: My spouse is an employee of Amgen Inc and we own stock in that
company, Part 2:My spouse is an employee of Amgen Inc and we own stock in that company,
Part 3: My spouse is an employee of Amgen Inc and we own stock in that company, Part 5: My
spouse is an employee of Amgen Inc and we own stock in that company.
Pizzagalli, Diego: Part 1: Pfizer, Otsuka.
Potter, William: Part 1: Advisory Boards of Lilly, Takeda, Amgen, Taisho, Part 2:Stock in
Merck.
Rasenick, Mark: Part 1: Eli Lilly, Pfizer, Part 2:Pax Neuroscience, Part 3: , Part 4: Eli Lilly,
Lundbeck.
Ray, Lara: Part 1: I have received study medication from Pfizer and from Medicinova. I have
consulted for GSK.
Rezai, Ali: Part 1: Board of Directors and equity shareholder for Autonomic Technologies Inc.
(ATI).
Robbins, Trevor: Part 1: Consultancy and Royalties, Cambridge Cognition; Consultancy;
Lundbeck, Otsuka, Teva, Shire Pharmaceuticals: Editorial honoraria, Springer Verlag, Elsevier,
Part 2:Cambridge Cognition. Otsuka, Part 3: Cambridge Cognition, Part 4: Research Grants
Lundbeck, Lilly, GSK.
Rubinow, David: Part 1: Sage Therapeutics, Inc (consulting and stock ownership); Amgen
(equity holdings); Dialogue in Clinical Neurosciences (editorial board); 6th annual Chairs
Summit 09/13 (honorarium received), Part 2:Dialogues in Clinical Neurosciences (editorial
board); Amgen (stock ownership), Part 4: Foundation of Hope (grant support).
Sawa, Akira: Part 4: MTPC, DSP, JNJ, Sucampo, Takeda, Astellas.
Schwarcz, Robert: Part 1: Vistagen, Part 2:Vistagen, Part 4: Mitsubishi-Tanabe, Lundbeck.
Simpson, Helen: Part 1: UptoDate Inc, Cambridge University Press, Transcept (research
support), Part 4: Transcept Inc (research funds for multi-site clinical trial).
Sohal, Vikaas: Part 1: Research support from Roche.
Stevens, Hanna: Part 1: Research Fellowship from APIRE/Wyeth (2010-2015), Part 4:
Research Fellowship from APIRE/Wyeth (2010-2015).
Swift, Robert: Part 1: Consultant to Farmaceutico CT- received fees, Advisory Board, D&A
Pharma - received honorarium, Speaker, Lundbeck - Received honorarium and travel expenses,
Part 2:Consultant to Farmaceutico CT- received fees, Part 4: Farmaceutico CT- Grant for
Clinical Study
Veenstra-VanderWeele, Jeremy: Part 1: Consulting: Roche, Novartis, SynapDx. Research
funding: Roche, Novartis, SynapDx, Seaside Therapeutics, Sunovion, Forest. Editorial:
Springer, Wiley, Part 4: Research funding: Roche, Novartis, SynapDx, Seaside Therapeutics,
Sunovion, Forest. Editorial: Springer, Wiley
288
11/10/15 9:59 AM
Vinogradov, Sophia: Part 1: Site PI on an SBIR grant to Positscience inc.; scientific advisory
board to Forum Pharmaceuticals; consultant to Takeda Pharmaceuticals., Part 4: Site PI on an
SBIR grant to PositScience, Inc.
Yocca, Frank: Part 1: Resilience Therapeutics, Bionomics, Part 5: BioXcel Corporation.
Presenters with nothing to disclose
Abulseoud, Osama
Carhart-Harris, Robin
Ahmari, Susanne
Carlat, Daniel
Ait-Daoud, Nassima
Carpenter, William
Akbarian, Schahram
Chattarji, Sumantra
Almasy, Laura
Chen, Chao
Alvarez, Veronica
Childress, Anna Rose
Anokhin, Andrey
Chiu, Pearl
Aponte, Yeka
Civelli, Olivier
Appelbaum, Paul
Clayton, Janine
Arango, Victoria
Coetzee, Timothy
Aston-Jones, Gary
Conant, Katherine
Bachtell, Ryan
Conrod, Patricia
Bakshi, Vaishali
Coughlin, Jennifer
Bale, Tracy
Creed, Meaghan
Balu, Darrick
Crespo-Facorro, Benedicto
Bangasser, Debra
Cuthbert, Bruce
Barr, Christina
Daws, Lynette
Bearden, Carrie
de Villers-Sidani, Etienne
Becker, Jill
de Wit, Harriet
Benveniste, Helene
Dichter, Gabriel
Beversdorf, David
Do, Kim
Bhatia, Triptish
Dulawa, Stephanie
Bilbo, Staci
Duman, Ronald
Bilek, Edda
Dunsmoor, Joseph
Binder, Elisabeth
Dzierba, Carolyn
Edwards, Emmeline
Boldrini, Maura
Enikolopov, Grigori
Bolshakov, Vadim
Etkin, Amit
Bonci, Antonello
Everitt, Barry
Borgland, Stephanie
Feinberg, Andrew
Bousman, Chad
Felger, Jennifer
Braff, David
Ferguson, Susan
Breiter, Hans
Ferre, Sergi
Brennand, Kristen
Forbes, Erika
Bucan, Maja
Frangou, Sophia
Buckholtz, Neil
Frank, Guido
Cahill, Larry
Freedman, Robert
Calakos, Nicole
Gabbay, Vilma
Cameron, Heather
Garavan, Hugh
Gasser, Paul
George, Mark
Gether, Ulrik
Gilmore, John
Goldman, David
Goldstein, Jill
Goldstein, Rita
Gordon, Joshua
Grant, Steven
Greenberg, Benjamin
Grueter, Brad
Gur, Ruben
Haass-Koffler, Carolina
Haber, Suzanne
Halene, Tobias
Harrison, Neil
Hashemi, Parastoo
Heilig, Markus
Heitzeg, Mary
Heller, Elizabeth
Hen, Rene
Henn, Fritz
Hiroi, Noboru
Hsu, David
Huntley, George
Hutchison, Kent
Ibrahim, Ibtihal
Iliff, Jeffrey
Jaffe, Andrew
Johnstone, Andrea
Jovanovic, Tanja
Kaiser, Roselinde
Kalivas, Peter
Karl, Tim
Keshavan, Matcheri
Kieffer, Brigitte
King, Mary-Claire
Kleinman, Joel
Koob, George
289
11/10/15 9:59 AM
Nothing to Disclose:
Koroshetz, Walter
Kroemer, Nils
Kuhn, Cynthia
Kwako, Laura
LaLumiere, Ryan
Langenecker, Scott
Lanius, Ruth
Leckman, James
Lee, Francis
Leibenluft, Ellen
Light, Gregory
Lim, Kelvin
Liu, Chunyu
Liu, Hesheng
London, Edythe
Lucki, Irwin
Luscher, Christian
Lutter, Michael
MacDonald, Matthew
Mackey, Scott
Mackey, Sean
MacKillop, James
Macleod, Malcolm
Maher, Brady
Marchetto, Maria
Martinez, Diana
Mathews, Carol
Mayfield, Dayne
McAdams, Carrie
McCarthy, Margaret
McClellan, Jon
McEwen, Bruce
McMahon, Francis
Meyer, Roger
Meyer, Urs
Milad, Mohammed
Miller, Andrew
Mitchell, Suzanne
Mizrahi, Romina
Morey, Rajendra
Nakamura, Richard
Nichols, David
Nimgaonkar, Vishwajit
Norrholm, Seth
O’Connor, Mary-Frances
Oller, D. Kimbrough
Ongur, Dost
Ozonoff, Sally
Palmatier, Matthew
Palmer, Abraham
Pariyadath, Vani
Pasca, Sergiu
Patel, Sachin
Paulus, Martin
Penzes, Peter
Quirk, Gregory
Ramchandani, Vijay
Rao, Rajini
Rapanelli, Maximiliano
Rapaport, Mark
Raznahan, Armin
Reichenberg, Abraham
Reissner, Kathryn
Ressler, Kerry
Richards, Erica
Richards, Jerry
Roberts, Laura
Rodriguez, Carolyn
Ron, Dorit
Rooney, William
Ross, Randal
Rothbaum, Barbara
Roussos, Panos
Sahay, Amar
Sanders, Stephan
Sartorius, Alexander
Scattoni, Maria Luisa
Schmahl, Christian
Schneider, Frank
Schneider, Isabella
Schulze, Thomas
Schwab, Markus
Schwandt, Melanie
Shannon Weickert, Cynthia
Shansky, Rebecca
Singh, Manpreet
Sinha, Rajita
Sisk, Cheryl
Smith, Alexander
Smoller, Jordan
Song, Hongjun
Sorg, Barbara
Spagnolo, Primavera
Stanwood, Gregg
Stein, Elliot
Stuber, Garret
Sweet, Robert
Szumlinski, Karen
Takayanagi, Yoichiro
Tapert, Susan
Tottenham, Nim
Treadway, Michael
Tye, Kay
Urs, Nikhil
Valentino, Rita
Velthorst, Eva
Versace, Amelia
Vervliet, Bram
Vichaya, Elisabeth
Volkow, Nora
Voon, Valerie
Wahlestedt, Claes
Weinberger, Daniel
Weiser, Mark
Weiss, Susan
Wemmie, John
Whelan, Robert
Witten, Ilana
Wilcox, Claire
Wolf, Marina
Woolley, Catherine
Zachariou, Venetia
Zakharenko, Stanislav
Zubieta, Jon-Kar
Zuo, Yi
290
11/10/15 9:59 AM
Notes
291
11/10/15 9:59 AM
Notes
292
11/10/15 9:59 AM
Aaronson, Scott
Abbott, Christopher
Abbott, Geoff
Abdalla, Aya
Abdallah, Chadi
Abdullah, Saeed
Abella, Rachel
Abelson, James
Abel, Ted
Abi-Dargham, Anissa
Ables, Jessica
Abraham, Antony
Abraham, Paul
Abrahams, Brett
Abulseoud, Osama
Acheson, Dean
Acland, Ben
Addington, Jean
Addy, Nii
Adinoff, Bryon
Adler, Caleb
Admon, Roee
Adolphs, Ralph
Agartz, Ingrid
Aggarwal, Manisha
Aghajanian, George
Agster, Kara
Ahmad, Maha
Ahmari, Susanne
Ahmed, Anthony
Ahn, Francisca
Ahn, Kwangmi
Aiello, Allison
Aitchison, Katherine
Ait-Daoud, Nassima
Aizley, Harlyn
Ajilore, Olusola
Akbarian, Schahram
Akiki, Teddy
Akil, Huda
Akintobi, Adriana
Akiskal, Hagop
Akkus, Funda
Alachkar, Amal
Alagapan, Sankar
Alaverdyan, Mher
Alberati, Daniela
Albers, Mark
Albott, Cristina
Albright, Sarah
Alcantara, Lyonna
221
189, 252
231
262
167, 174, 178, 219
181
280
173, 250, 263
208, 210
2, 24, 41, 66, 202,
231, 268, 269
280
252
240
228
145
247
274
230, 270, 271, 272
253
198
2, 176, 220
180
207, 264
232
272
194
208
220
103, 212
228
213
249
206
173
163
165, 176
2, 185, 215, 222,
252
99, 192, 225, 228
182
173, 217, 248, 261
192
258
32, 266
185, 231
233
263
267
71, 185
260
166
218
Alda, Martin
Alegria, Margarita
Alex, Grassetti
Alexander, David
Alexander, Heather
Alexanderson, Kristina
Aleyasin, Hossein
Al-Hasani, Ream
Alhassen, Lamees
Ali, Kawthar Al
Alia-Klein, Nelly
Alipio, Jason
Allen, Josiah
Allen, Nicholas
Almasy, Laura
Almeida, Jorge
Almli, Lynn
Alonso-Caraballo, Yanaira
Alphs, Larry
Alshammari, Musaad A.
Alshammari, Tahani K.
Altar, C. Anthony
Althoff, Robert
Altinay, Murat
Alvarez, Alexis
Alvarez, Veronica
Alvaro, Giuseppe
Alvaros, Nathaniel
Amaro, Edson
Amboni, Rafaela
Ameis, Stephanie
Ametamey, Simon
Amgalan, Airunzaya
Anacker, Allison M.J.
Anacker, Christoph
Anagnostou, Evdokia
Anand, Amit
Anastasio, Noelle
Andersen, Haley
Andersen, Monica
Andersen, Susan
Anderson, Eric
Anderson, Ethan
Anderson, Henrik Steen
Anderson, Rachel
Anderzhanova, Elmira
Andion, Oscar
Andreassen, Ole
Andreazza, Ana
Andre, Haymer
Andrews, Anne
Andrews, Jessica L.
Aneja, Monika
181
165
281
225
186
188
213
253
185
258
236, 275
173
256
276
77, 141, 182, 269
261
206
246
253
266
266
256
278
254
190
132, 189, 260
187
279
261
254
209, 210
32, 266
276
237
254
210
254
252
274
254
2, 250
246
198
265
236
214
264
232
174
167
2, 167
227
179
293
11/10/15 9:59 AM
Angarita-Africano, Gustavo
Angela, Ziluk
Angstadt, Michael
Anhøj, Simon
Anokhin, Andrey
Anthony, James
Anticevic, Alan
Anton, Raymond
Antonius, Daniel
Aponte, Yeka
Appelbaum, Paul
Apud, Jose A.
Arango, Celso
Arango, Victoria
Arbuckle, Melissa
Archuleta, Solana
Arguello, Amy
Argyelan, Miklos
Arime, Yosefu
Arion, Dominique
Arner, Jay
Arnold, Paul
Arnow, Bruce
Arolt, Volker
Aronson, Sarah
Arora, Manish
Arous, Francoise Guillo-Ben
Arreola, Adrian
Arulpragasam, Amanda
Arver, Stefan
Ashare, Rebecca
Ashley-Koch, Allison
Aslam, Haris
Aston, Andrew
Aston-Jones, Gary
Athappilly, Geena
Atkin, Talia
Atoui, Mia
Atram, Michal
Auger, Meagan
Aujla, Paven
Auriemma, Alyson
Austelle, Christopher
Avena, Nicole
Averill, Christopher
Averill, Lynnette
Avery, Jason
Aydin, Cigdem
Ayers-Ringler, Jennifer
Ayoub, Adam
Babb, James
Bachman, Peter
197
271
206
234
112
200, 238
219
163, 275
189
101
137
227, 233
250
117, 254
223
208
201
226, 255, 272
191
233, 273
169
210
207
166
241
266
205
91, 195
178
195
200
248
180, 218
248
2, 145, 238, 239,
260, 275
181
229
258
280
193
183
199
261
212
167
219
222
217
214
208
185
272
Bachtell, Ryan
Badner, Judith
Badran, Alan W.
Badran, Bashar
Baer, Lee
Baglietto-Vargas, David
Bagot, Rosemary
Bahmani, Dena Sadeghi
Bailer, Ursula
Bailey, Michael
Bailine, Samuel
Bakalian, Mihran
Baker, Dewleen
Baker, Justin
Baker, Ross A.
135, 208
267
261
258, 261
179
211
178, 195
176
171, 212
211
234
254
207, 247
271, 273
177, 180, 191,
192, 232, 265
Baksh, Nausheen
246
Bakshi, Vaishali
117, 165, 205, 245
Bale, Tracy
7, 12, 13, 114, 152
Ballard, Elizabeth
206, 215
Ballard, Michael
195
Ballard, Theresa
267
Ballinger, Michael
265
Balmuth, Evan
278
Balodis, Iris
196
Balsam, Peter
212
Balu, Darrick
97, 192
Balvaneda, Bryan
226
Bame, Monica
222
Banerjee, Dipavo
215
Bangasser, Debra
114, 246
Bank, Andrew
179
Banks, Matthew
240
Bansal, Ravi
260
Baraban, Jay
170
Barabássy, Ágota
88, 194
Baram, Tallie Z.
175, 252
Barber, Caroline
166
Barbieri, Riccardo
176
Barbosa, Paulo Cesar Ribeiro 261
Bar-Haim, Yair
207, 209
Barker, Jacqueline
235
Barr, Christina
117, 165, 205,
245, 248, 264
Barr, Mera
186, 229, 235
Barres, Ben
262
Barrett, Lisa Feldman
246
Barrett, Marna
257
Barrus, Michael
200
Bartels, Stephen
165
Bartfeld, Benjamin
193
Barth, Claudia
27, 260
Bartley, Aundrea F.
270
294
11/10/15 9:59 AM
Barton, Bruce
Batistuzzo, Marcelo
Batuman, Olcay
Bauer, Isabelle
Bauer, Moisés Evandro
Baxter, Mark
Beall, Erik
Bearden, Carrie
Beas, B. Sofia
Beasley, Charles
Beaulieu, Jean-Martin
Bebko, Genna
Beck, Johannes
Becker, Howard
Becker, Jill
Becker-Krail, Darius
Begale, Mark
Beggel, Odeta
Beillat, Maud
Belger, Aysenil
Belikova, Yelena
Belin, David
Belin-Rauscent, Aude
Bellon, Alfredo
Benavides, Caridad
Benca, Ruth
Bendriem, Raphael
Benes, Francine
Benkelfat, Chawki
Bennett, David
Bennett, Natasha
Benson, Andrew
Bentham, Matthew
Bentzley, Brandon
Benveniste, Helene
Berger, Anthony
Berges, Victoria
Bergman, Jack
Bergmann, Joy
Berman, Alexandra
Berman, Karen
Berman, Mitchell
Berman, Sarah
Bermejo, Marie Kristel
Bernabe, Cristian
Bernardi, Julio
Bernardo, Leah
Berner, Laura
Bernier, Brian
Berns, Adam
Berretta, Sabina
175
247, 248
178
181
210
170, 188
254
136, 233, 271
245
137
174
180, 218
180
236
114
241
179
226
232, 265
214, 232, 272
206
195
195
269
41, 268
211
196
192
200, 236
251
270
170
179
239
108
257
170
238
246
237
224, 227, 234,
245, 249, 251,
265, 267
252
258
272
247
253
200
251
208
193
271
Bersani, Francesco Saverio
Bershad, Anya
Bertoldo, Alessandra
Bertolino, Alessandro
Bertrand, Sarah
Bertz, Jeremiah
Bespalov, Anton
Best, Janet
Bethea, Cynthia
Beurel, Eleonore
Beversdorf, David
Bevilaqua, Arturo
Beyeler, Anna
Bhakta, Savita
Bhandal, Amandeep
Bharadwaj, Rahul
Bharath, Rose
Bhat, Shambhu
Bhatia, Triptish
Bhatnagar, Seema
Bianchini, Guilherme
Bicks, Lucy
Biederman, Joseph
Biehl, Matthew
Bielen, Kim
Bienko, Nicholas
Biernacka, Joanna
Bies, Robert
Bigio, Benedetta
Bigos, Kristin
Bilbo, Staci
Bilder, Robert
Bilek, Edda
Bilker, Warren
Binder, Elisabeth
Biondi, Massimo
Bischoff-Grethe, Amanda
Bishop, Courtney
Bishop, Jeffrey
Bison, Chris
Bittner, Genevieve Van de
Bixler, Edward
Bizon, Jennifer
Bizzell, Joshua
Björkholm, Carl
Blackburn, Elizabeth
Blacker, Caren
Blacker, Deborah
Blackford, Jennifer
Blacktop, Jordan
Blair, Laura
271
237
270
174, 212
255
189
104
262
206, 247
257
129, 251
271
62, 64, 65, 182
190, 226
205
245
267
205
126, 228
247
254
228
249
183
241
224
214
187
257
223
129
224, 239
150
229
7, 14, 15, 165,
205, 206, 214,
245, 255
271
171, 212, 251
184
267
172
62, 71, 72, 73, 185
277
183, 245
214
191
177
214
171
167
274
255
295
11/10/15 9:59 AM
Blakely, Randy
Blanco, Carlos
Blandino, Peter
Blangero, John
Blasi, Giuseppe
Blennow, Kaj
Blier, Pierre
Bloch, Michael
Block, Stefanie
Blokland, Gabriella
Blom, Thomas
Bloomfield, Michael
Bloomfield, Peter
Blough, Bruce
Bluett, Rebecca
Bluez, Grai
Blumberger, Daniel
Boak, Lauren
Bobadilla, Ana-Clara
Bocarsly, Miriam
Bodurka, Jerzy
Bogdanova, Olena
Bogenschutz, Michael
Boger, Heather
Bohannon, Andrew
Bohn, Laura
Bohus, Martin
Boileau, Isabelle
Boldrini, Maura
Bollati, Flavia
Bolshakov, Vadim
Bonab, Ali
Bonaventure, Pascal
Bonci, Antonello
Bonoldi, Ilaria
Bookheimer, Susan
Booze, Rose Marie
Borckardt, Jeffrey J.
Borgland, Stephanie
Boroda, Elias
Bortz, David M.
Boshoven, William
Bouril, Alexander
Bousman, Chad
Bowman, Nicole
Boyd, Savannah
Boyle, Michael
Braas, Karen
Brachman, Rebecca
Bradbury, Angela
Bradler, Kamil
Bradley, Bekh
183, 209, 237
212, 277
217
77, 182, 269
174, 212
217, 225
217, 256
257
248, 250
190
176, 220
270
270
235
167
241
235, 259
217
241
260
222
219, 238
157, 261
236
226, 270
158, 201
264
237
2, 140, 218
109
241
133
261
20, 48, 49, 50, 176
2, 132, 145
270
224
255
261
132
273
235
189
200
139
208, 210
165
233
222
173
171
181
81, 182, 206
Bradley, Kailyn
Brady, Kathleen
Brady, Linda S.
Braff, David
Braga, Raphael
Bralet, Marie-Cecile
Brammer, Michael
Brammer, Richard
Brandon, Nicholas
Brand, Serge
Brasic, James
Bredt, David
Breier, Alan
Breiter, Hans
Brenhouse, Heather
Brennan, Brian
Brennand, Kristen
Bressan, Rodrigo
Brewer, Michelle
Briand, Lisa
Brian, Jessica
Brian, Scott
Brietzke, Elisa
Briggs, Richard
Britton, Jennifer C.
Broberg, Brian
Brody, Arthur
Bromberger, Joyce
Brooks, Julie
Brookshire, Stephen
Brotman, Melissa
Brown, Alan
Brown, Angelo
Brown, Chelsea
Browne, Caroline
Brown, Elliot
Brown, E. Sherwood
Brown, Gregory
Brown, Hallie
Brown, Heidi
Browning, Michael
Browning, Philip
Brown, Ritchie
Brown, Robyn
Brown, Walter
Bruce, Steven
Bruchas, Michael
Bruijnzeel, Adriaan
Bruno, Davide
Bruno, John
Brust, Tarsis
Brutsche, Nancy
250
196
116
141
234, 270
266
180
171, 183
231, 249, 265
176, 180
225, 268
185
272
115
209, 250
168
141, 228, 263
171
239
91, 195, 197
210
218
277
198
207
234
240
259
190
170
165, 205, 209,
213, 245
171
224
279
255
187
174
232
210
249
180
170
227
241
177
178
198, 253, 274
235
217
2, 235
189
215
296
11/10/15 9:59 AM
Bryan, Angela
Bryant, Camron
Bucan, Maja
Bucci, David
Buchanan, Robert
Buchsbaum, Monte
Buchta, William
Buck, Alfred
Buckholtz, Neil
Buckner, Alex
Buckner, Randy
Buczynski, Matthew
Bueno Jr., Lezio
Bui, Eric
Bujarski, Spencer
Bukwich, Michael
Bullmore, Edward
Bumb, Jan Malte
Bunce, Scott
Bunney, William
Burch, Kathleen
Burdick, Katherine
Burgdorf, Caitlin
Burgeno, Lauren
Burger, Cyrill
Burgess, Ashley
Burghardt, Kyle
Burghy, Cory
Burket, Jessica
Burmann, Inga
Burns, Carol
Burns, Sarah
Burris, Kevin
Burrows, Kaiping
Busatto, Geraldo
Busch, Eric
Bustamante, Angela
Bustillo, Juan
Butelman, Eduardo R.
Buxbaum, Joseph
Cabrera, Elizabeth
Caceda, Ricardo
Cadenhead, Kristin
Caers, Ivo
Cagliero, Diana
Cahill, Larry
Cahuzac, Emma
Calabrese, Joseph
Calakos, Nicole
Calarco, Cali
Caldwell, Jody
Caldwell, Sorana
Calhoun, Vince
280
197
119
229
187
266
275
32, 266
18
228
222, 231, 271
279
241
246
237, 280
30, 281
274
264
98, 277
192, 256
273
215, 255, 256, 257
229
274
32, 266
271
234
169
170
27, 260
216
247
185
222
261
196
206
189, 232
179
206, 249
279
254
271, 272
181
260
53, 59
179
214, 252
124
253
258
270
232, 269
Calipari, Erin
Calkins, Monica
Callaghan, Paul D.
Callahan, Shawn
Callicott, Joseph
Calvo, Ana
Cambiaghi, Marco
Camchong, Jazmin
Cameron, Heather
Cameron, Judy
Campbell, Allison
Campbell, Rianne
Campeau, Serge
Camprodon, Joan
Camuso, Julia
Can, Adem
Cancela, Liliana M.
Canive, Jose
Cannady, Reginald
Cannon, Ty
Canteras, Miguel
Canuso, Carla
Cao, Bo
Cao, Dingcai
Cao, Jun-Li
Cao, Luxiang
Cao, Wen
Caouette, Justin
Cappi, Carolina
Caravaggio, Fernando
Carazo, Elena
Carhart-Harris, Robin
Carhart, Joseph
Carlat, Daniel
Carless, Melanie A.
Carlezon, William
Carneiro, Nicoli
Caron, Marc
Carpenter, Linda
Carpenter, William
Carreira, Maria
Carrion, Joseph
Carrion, Ricardo
Carroll, Kathleen
Carroll, Marilyn
Carson, Richard
Carter, Cameron
Cartwright, Emily
Carvalho, Andre
Casas, Miguel
Case, Julia
Caselli, Richard J.
Casement, Melynda
39, 195, 201
211, 220
214
232
265, 267
250
266
210, 238, 239, 273
109, 239
206, 247
246
202
208
256, 257
181
272
241
189, 232
199
233, 271, 272
247
253, 268
219
199
68, 194
71, 185
200
250
248
186, 187, 226
262
157
256
137
269
221, 231
214
158, 188, 268
166, 217, 221, 261
137
278
201
272
196
279
174, 197, 276
229, 273
175
254
264
250
171
259
297
11/10/15 9:59 AM
Cash-Padgett, Tyler
Casper, Corey
Cassidy, Clifford
Castellanos, Francisco
Castelli, Maria Paola
Catana, Ciprian
Catanesi, Roberto
Cates, Hannah
Cather, Corinne
Centanni, Sam
Cerqueira, Carlos
Chaarani, Bader
Chadderdon, Aaron
Chahroudi, Ann
Cha, Jiook
Chaki, Shigeyuki
Chakravarty, Mallar
Chamberlain, Samuel
Chambers, Betsey
Chan, Nicholas
Chandler, L. Judson
Chandon, Toni-Shay
Chandra, Ramesh
Chandra, Upasana
Chang, Andrew
Chang, Annie
Chang, Da-Jeong
Chang, Daniel
Chang, Eric
Chang, Kiki
Chao, Dong
Chao, Moses
Chapel, Sunny
Charney, Alexander
Charney, Dennis
Chase, Henry
Chase, Thomas
Chassan, Rachel
Chattarji, Sumantra
Chatzittofis, Andreas
Chau, David
Chau, Peggy
Chaudhury, Dipesh
Chavez, Sofia
Chavkin, Charles
Cheer, Joseph
Chen, Alon
Chen, Chao
Chen, Cho-Yi
Chen, Guang
Chen, Jiayu
Chen, Lihui
Chen, Meng
192
181
41, 66, 202, 268
210
240
231
212
178
198
169
261
278
246
175
173
176
186, 209
172
168
193
169, 235
272
276
249
170
233
248
184
272
125
173
189, 193
172
192
255, 260
180, 218
251
217
143
195
220
257
68, 194
269
252, 255
195
214
126, 187
185
181, 214, 218, 253
232
212
268
Chen, Mu-Hong
233
Chen, Qiang
223, 245, 265, 274
Chen, Rudy
240
Chen, Wei
178
Chen, Wen
186
Chen, Xin
219, 268
Chen, Yue
189
Chen, Yuncai
175, 252
Cheng, Chih-Ming
233
Cheng, Riyan
197
Chesler, Elissa J.
196
Cheung, Iris
228
Chiaie, Roberto Delle
271
Chiappelli, Joshua
272
Chiara, Gaetano Di
235, 240, 280
Chibnik, Lori
251
Childress, Anna Rose
115, 200, 279
Childs, Emma
236
Chioma, Vivian
276
Chiu, Pearl
115
Chiu, Yu-Yuan
172
Cho, Jae
191
Cho, Raymond
165, 205, 245, 270
Choi, Du-Sup
214
Choi, Eric
184
Choi, Ki Sueng
258
Choi, Y.K.
171
Choi, YuBin
214
Choo, Jocelyn
214
Chou, Hsun-Hua
226
Choudhury, Tanzeem
181
Chouinard, Guy
193
Chouinard, Virginie Anne
193
Christensen, Michael Cronquist175
Christoffel, Daniel
213
Chuang, De-Maw
210
Chung, Jerome
170
Ciarleglio, Adam
217
Cicek, Ercument
249
Cisler, Joshua
168
Citrome, Leslie
191
Civelli, Olivier
153, 185, 231
Clarence-Smith, Kathleen
251
Clark, Brian
208
Clark, Jeremy
195
Clark, Michael
260
Clarke, Laura
262
Clauss, Jacqueline
167
Clayton, Anita
221
Clayton, Janine
114
Cleef, Arriel Van
251
Clinton, Sarah
170
Coate, Heather
48, 176
298
11/10/15 9:59 AM
Coccaro, Emil
Cocchiaro, Gina
Coe, Marion
Coetzee, Timothy
Cohen, Bruce M.
Cohen, Hagit
Cohen, Lee
Cohen, Sarah
Cohen, Vanessa
Cohensedgh, Omid
Coker, Jessica
Cole, Robert
Collins, Gregory
Collins, Katherine
Colon-Perez, Luis
Colrain, Ian
Comer, Sandra
Conant, Katherine
Connors, Barry
Conn, P. Jeffrey
Conrin, Sean
Conrod, Patricia
Conroy, Jennie
Conroy, Kaitlin
Constantine, Adam
Conte, Giorgio
Conway, Charles
Conyers, Garret
Cook, Benjamin
Cook, Phillip
Cooper, Kimberly
Cooper, Sarah
Cooper, Yonatan
Coplan, Jeremy
Corcoran, Cheryl
Corey, Kristin
Corey, Linda
Corlett, Philip
Cornblatt, Barbara
Cornier, Marc-Andre
Corradi, John
Correll, Christoph
Corrin, Garr Sarah
Cortes-Briones, Jose
Cortese, Bernadette
Cortes, Michelle
Cosgrove, Kelly
Costa, Douglas
Costa, Fabiana
Cottone, Pietro
Coughlin, Jennifer
Couto, Lizette
Cowan, Christopher
225, 252
222
237
107
193, 271, 273
206
181, 216
246
240
237
238
193
200
219
275
274
100, 198
120
225
245, 268
222
121
189
211
217
215
178
64, 182
165
178
220
197
278
178
2, 234
242
275
228
271, 272
262
233
270
169
241, 276
167
172
197
247
248
212, 253
111, 224
240
198, 278, 279
Cowell, Rita M.
Cox, Brittney
Cox, Sylvia
Coyle, Joseph
Cranston, Michael
Crawford, Cynthia
Crawford, Sybil
Creatura, Gina
Creeden, Justin
Creed, Meaghan
Crespo-Facorro, Benedicto
Cribbs, David
Cristiano, Claudia
Croarkin, Paul
Cropp, Brett
Crosbie, Jennifer
Cross, Alan
Crowell, Andrea
Crowley, Nicole
Croxall, Matthew
Croxson, Paula
Crumiller, Marshall
Cuartero-Toledo, Maria
Cucchiaro, Josephine
Cuesta-Diaz, Armando
Cugola, Fernanda
Cui, Harry
Cui, Lihong
Cullen, Kathryn
Cullum, C. Munro
Cummings, Jeffrey
Cunningham, Ashley
Cunningham, Kathryn
Cunningham, Mark
Cunningham, Samantha
Curran, Joanne
Curran, Mark
Curtis, André
Cuthbert, Bruce
Cutler, Andrew J.
Czarapata, Jasmin
Czoty, Paul
Dagher, Alain
D’Agostino, Giuseppe
Dahlberg, Allison K.
D’Aiuto, Leonardo
Daly, Ella
Damani, Imran
D’Amico, Stephen
Dan, Ragland
D’Anci, Kristen
Daniel, Sarah
270
239
200
2, 133, 192, 231
255
165, 205, 245
181
241, 276
279
145
139
211
245
169, 209, 210
224
210
249, 265
258
253
267
170, 192, 263
68, 194
205
172, 252, 268
215, 255, 256, 257
251
185
206, 220
210
230
185
262
252
187
279
77, 182, 269
181
169
18, 107, 126, 134,
189
225
224
242
200
245
270
223
220
232
225
229
219
166
299
11/10/15 9:59 AM
Darvasi, Ariel
Daskalakis, Nikolaos
Daskalakis, Zafiris
273
206, 240
209, 229, 235,
259, 271
Das, Saumitra
245
Das, Sujan
275
Davatzikos, Christos
211
David, Thomaas
238
David, Denis
173
Davidsen, Charlotte Kampp
180
Davidson, Colin
240
Davidson, Michael
2, 233
Davidson, Paul
224
Davidson, Richard
37, 169, 176
Davidson, Rina
228
Davidson, Thomas
195
Davis, Andrew
206
Davis, Erica A.
189
Davis, Gwynne
209
Davis, John
192
Davis, Jon
251
Davis, Margaret
197
Davis, Robert
267, 268
Davoren, Jennifer
261
Daws, Lynette
162, 214
Dawson, Gerard
180
Day, Jeremy
270, 274
Deakin, Bill
187
Dean, Andy
239
Deaso, Emma
241
Debelle, Marc
88, 187, 194
Debiec, Jacek
248
DeBold, Joseph
238
deBruecker, Geert
220
Dechairo, Bryan
256
Deckersbach, Thilo
178, 221, 256
Deckert, Jürgen
166
Dedic, Nina
214
Deehan Jr., Gerald
264, 277
DeFina, Laura F.
174
De Francisco, Don
199
Deisseroth, Karl
195
De Jager, Philip
251
de la Fuente-Sandoval, Camilo 269
Delaney, Scott
200
DelBello, Melissa
2, 125, 176, 220
Del’Guidice, Thomas
174
Deligiannidis, Kristina
175
DeLisi, Lynn E.
228
DellaGioia, Nicole
174
DeLong, Cynthia
222
DeLorenzo, Christine
174
De Luca, Maria Antonietta
240
De Luca, Vincenzo
Demars, Michael
de Mathis, Alice
Demitrack, Mark
Deng, Shixian
Deng, Zhi-De
Deniri, Jennifer
Denney, Thomas
Denny, Bryan
Denny, Christine
Denys, Damiaan
de Paola, Vincenzo
Deptula, Denis
de Quevedo, Joao
Der-Avakian, Andre
Der-Ghazarian, Taleen
DeRosse, Pamela
Desai, Rajeev I.
Deshpande, Smita N.
Detke, Michael
Deussing, Jan M.
Deutch, Ariel
Deutsch, Stephen
Deveau, Nicholas
Devinsky, Orrin
Devlin, Bernie
DeVries, William
Dewey, Stephen L.
DeWilde, Kaitlin
de Wit, Harriet
Dias, Elisa
Diaz-Mataix, Lorenzo
Diaz, Maylen Perez
Dichter, Gabriel
Di Ciano, Patricia
Dickerson, Jonathan
Dickey, Chad
Dickinson, Dwight
Dickstein, Daniel
Dienstag, Jordan
Dietrich, Julie
Dietz, David
DiLeone, Ralph
Di Martino, Adriana
Dimitrion, Peter
Dincer, Aslihan
Ding, Chunjin
Ding, Ying
Ding, Yu-Shin
Dinnisa, Wang
DiPaula, Bethany A.
Dixon, Hayley
Dlugolenski, Keith
178, 271
188
248
221
229
174, 254
179
267
186
173
145
270
217
254, 257
259
278
2, 230
238
228
263, 265
214
2
2, 170
211
185
249
216, 258, 261
201
219
100, 154, 201, 237
234
252
278
149, 214
237
245, 268
255
234, 267
174
272
187
218, 276
253
210
223
192, 225
185
193
185
281
189
259
261
300
11/10/15 9:59 AM
Do, Kim
Dobrunz, Lynn E.
Docherty, John
Dolgalev, Igor
Dolmetsch, Ricardo
Domschke, Katharina
Donahue, Manus
Donahue, Myles
Donahue, Rachel
Donaldson, Zoe
Dong, Erbo
Dong, Kong
Dong, Yan
Dong, Zheng
Dong, Zhengchao
Donthamsetti, Prashant
Doody, Rachelle
Dopke, Cynthia
do Prado, Carine Hartmann
Dorcius, David
Doucette, Wilder
Dougherty, Darin
Dougherty, John
Doumit, Mark
Dourish, Colin
Dowdle, Logan
Dowd, Sheila
Dowlati, Yekta
Doyle, Marie
Doyle, Trevor
Dracheva, Stella
Drevets, Douglas
Drevets, Wayne
Drew, Michael
Driscoll, Carlos
Driskill, Christopher
D’Souza, Deepak
Du, Fei
Du, Heng
Duan, Yinghui
Dubé, Sanjay
Dubey, Neelima
Dubin, Marc
Dubocovich, Margarita L.
Dudley, Joel
Duffy, Ruth A.
Duggirala, Ravi
Dugovic, Christine
Dujmovic, Tatjana
Dulawa, Stephanie
Duman, Catherine
133
270
193
189
151
166, 167
277
221
221, 231
262
230
208
178
274
66, 202
189, 190, 229
225
179
210
251
211, 229
2, 168, 178, 256,
257
224
182, 258
175, 180
196
221
221
178
189
192
216
142, 181, 216,
218, 220, 222, 253
208
264
230
241, 276
193
230
262
185
181
260
220
192, 225
177, 192
77, 182, 269
48, 176
262
2, 103, 215
194
Duman, Ronald
Dumas, Julie
Dunayevich, Eduardo
Duncan, Erica
Dunner, David
Dunsmoor, Joseph
Durand, Dante
Durand, France
Duran, Fabio
Durgam, Suresh
Durling, Michelle
Duval, Elizabeth
Duvio, Dalton
Duvvuri, Vikas
Dvorak, Curt
Dwivedi, Yogesh
Dyer, Adam
Dyer, Thomas
Dykes, Steve
Dyukova, Elena
Dzierba, Carolyn
Eagle, Andrew
Earley, Willie
Ebdrup, Bjørn H.
Ebrahimzadeh, Mohammad
Echeazu, Ifeoma
Echevarria, Barbara
Eckert, Anne
Eckert, William
Edelson, Jessica
Edgerton, Jeremy
Edwards, Emmeline
Edwards, John
Edwards, Scott
Ehlers, Cindy
Ehrich, Elliott
Ehrlich, Stefan
Ehrman, Ronald
Ehses, Janina
Eijsink, Vivian
Eiland, Lisa
Eisenberg, Daniel
Eisen, Jane
Eisert, Albrecht
Ekstrom, Tor
Ellard, Kristen
Ellingrod, Vicki
Elliott, Mark
Elman, Igor
Elmer, Greg
El Mestikawy, Salah
Ely, Alice
Ely, Timothy
152, 174, 194
165
187
189, 272
221
143
226
200
247
88, 187, 194, 229
220
250
217
251
48, 176
179
210
269
183
231
153
216
194, 229
265
256
199
265
180
48, 176, 218
191
261
131
229
208, 275
2, 172, 275
155
232
279
71, 185
213
221
224, 249, 251
223
215
189
256, 257
234
228, 229
200
184
236
212
264
301
11/10/15 9:59 AM
Emmitte, Kyle
Emslie, Graham
Engeln, Michel
Enikolopov, Grigori
Enkhuizen, Jordy van
Enning, Frank
Ennis, Elizabeth
Enoch, Mary-Anne
Enoki, Ryu
Enwright, John
Epel, Elissa
Epperly, Phillip
Epperson, C. Neill
Epstein, David
Epstein, Michael
Eramo, Anna
Erikson, Chloe
Erkanli, Alaattin
Ernst, Monique
Erp, Theo van
Erus, Guray
Eryilmaz, Hamdi
Eshel, Neir
Eskay, Robert
Esparza, Maria A
Essex, Marilyn
Esterlis, Irina
Esterman, Michael
Estes, Myka
Ethun, Kelly
Etkin, Amit
Evans, Gary
Evans, Travis C.
Everitt, Barry
Evins, Anne
Evron, Tama
Eyre, Harris
Fagerlund, Birgitte
Fakira, Amanda
Falcon, Edgardo
Falcone, Karina
Falcone, Mary
Falk, Daniel
Falkai, Peter
Fan, Jin
Fan, Xiaoying
Fang, Yu
Fani, Negar
Fanning, Jennifer
Fannon, McKenzie
Faraone, Stephen
189
209
276
109
255
264
183
2, 247
240
233
177
242
177, 216
201
226
177, 192, 232, 265
280
174
206
232
211
231
19, 30, 31, 281
237
241
169
174
249
273
175
150, 207
170
207
2, 113, 195
115, 198, 224,
242, 275
188
165
265
237
255
236
200
200
188
186
193
170, 206
62, 81, 82, 182,
264
225, 252
239
169
Farde, Lars
Farino, Zachary
Farokhnia, Mehdi
Farooq, Muhammad
Farrelly, Lorna
Farzan, Faranak
Fatemi, Ali Bani
Faucett, James
Fausett, Jennifer S.
Faust, Travis
Fava, Maurizio
Favo, Daly
Faye, Charlene
Febo, Marcelo
Federici, Lauren
Fedgchin, Maggie
Fehr, Tristan
Feifel, David
Feinberg, Andrew
Feinstein, Justin
Felger, Jennifer
Felsky, Daniel
Feng, Jian
Feng, Ningping
Fenster, Robert
Ferguson, Susan
Ferland, Jacqueline-Marie
Fernandez-Enright, Francesca
Fernandez, Guillen
Fernandez, Joseph
Fernandez, Thomas
Ferragud, Antonio
Ferrarelli, Fabio
Ferrario, Carrie
Ferre, Sergi
Ferreira-Cornwell, Celeste
Ferrer, Marc
Ferris, Craig
Ferris, Mark
Fertig, Joanne
Fervaha, Gagan
Feuillet, Vincent
Feusner, Jamie
Fieve, Ronald
Filho, Ledo Daruy
Filss, Christian Peter
Fineberg, Naomi
Fischer, Simon
Fischman, Alan
Fish, Kenneth
Fisher, Sydney
Fitz, Stephanie
Fitzgerald, Dan
173
190
201
275
263
259
271
177
184
192
174, 177, 217, 257
273
173
183, 235, 275
247
218, 220, 253
228
232
141
207, 264
123, 219, 220, 259
209, 251
213
230
263
113, 252
200
227
232
223
250
212, 253
188
246
135
171
189, 264
209
197
200
266
269
207, 222
185
210
215
166
232
261
187
211
247
222
302
11/10/15 9:59 AM
Fitzgerald, Kate
Fitzgerald, Megan
Fitzpatrick, Christopher
Flagel, Shelly
Flagg, Victoria
Flaherty, Daniel
Flanigan, Meghan
Fleischer, Candace
Fleischhacker, Wolfgang
Fleites, Vanessa
Fleming, Weston
Flick, Katelyn
Fling, Connor
Floresco, Stan
Flores-Ramirez, Francisco
Flory, Janine
Fluegel, Brandon
Fogelman, Phoebe
Foley, Mary
Foll, Bernard Le
Foltin, Richard
Fonseka, Trehani
Fontes, Beatriz Antolin
Fontoura, Paulo
Fonzo, Gregory
Forbes, Angus
Forbes, Erika
Ford, Judith
Fordahl, Steven
Forma, Felicia
Formella, Andrea
Forray, Ariadna
Forray, Carlos
Forsberg, Anton
Foster, Jane
Foussias, George
Fox, Andrew
Fox, James B.
Fox, Michelle
Fox, Nathan A.
Fox, Peter T.
France, Charles
Francesconi, Marta
Francis, Michael
Francis, Reynold
Francis, T. Chase
Frangou, Sophia
Frank, Ellen
Frank, Guido
Frank, Heather
Franke, Barbara
Franke, Nathalie
246
254
279
261
220
279
213
219
88, 194, 229, 233
255
249
206
263
193
173
206
176
220
257
235, 237
198
256
280
217
207
215
140, 165, 205,
245, 250
44, 188, 232
39, 201
193
225
276
232, 265
173
256
266
246
216
169
207
269
200
271
272
249
276
134
181
138
209, 213
232
266
Franklin, Rachel
Franklin, Teresa
Franklin, Tina
Fraser, Benjamin H.
Fraser-Spears, Rheaclare
Frazer, Alan
Frazier, C. Jason
Frederick, Blaise
Free, R. Benjamin
Freedman, Robert
Freed, William
Freeman, Ellen W.
Freeman, Marlene
Freeman, Natalie
Freemantle, Nicholas
Freid, Cathryn
Freund, Nadja
Freyberg, Robin
Freyberg, Zachary
Fridman, Gene
Friedland, Kristina
Friedman, Allyson
Friedman, Jeffrey
Frisoni, Giovanni
Froeliger, Brett
Frohlich, Flavio
Frohmader, Karla
Frölich, Michael
Frolov, Boris
Frye, Mark
Fryer, Susanna
Fuccillo, Marc
Fuchs, Dietmar
Fuchs, Rita
Fucich, Elizabeth
Fujita, Masahiro
Fukuda, Shinji
Fukudome, Daisuke
Fukumoto, Kenichi
Fukunaga, Rena
Fultz, Elissa
Fung, Lawrence
Furey, Maura
Furnari, Melody
Gabbay, Vilma
Gabriele, Amanda
Gaddis, Laura
GadElkarim, Johnson
Gajewska, Agnes
Gajewski, Paula
Galea, Sandro
Galfalvy, Hanga
178, 248
279
174
214
214
2
245
277
189
104, 144, 168
196
177
181, 216
256
257
181
250
190
190
170
245
68, 194, 256
68, 194
170
167
233
217
86, 194
225
169, 214
20, 44, 45, 188
79, 184
272
201
62, 74, 75, 76, 168
35, 36, 172, 177,
182
261
192
176
179
202
183
179, 218
201
134, 250
197
226
222
166
216
206
167
303
11/10/15 9:59 AM
Galinato, Melissa
Gali, Raül Andero
Gallego, Juan
Gallus, Nancy
Galvan, Thania
Gamaleddin, Islam
Gan, Gabriela
Gancarz, Amy
Gangadhar, Bangalore
Gao, Keming
Gao, Ming
Garavan, Hugh
Garcia, Ilan
Garcia-Keller, Coti
Garcia, Kevin
Garcia, Lizette
Garcia, Nacire
Garcia, Ronald
Gardette, R.
Gardier, Alain
Gardinier, Kevin
Garlow, Steven
Garrett, Melanie
Garst-Orozco, Jonathan
Garza, Jacob
Garzio, Lori
Gasior, Maria
Gasparovic, Charles
Gass, Justin
Gasser, Paul
Gaston, Frank
Gatti, Dan
Gatti, Silvia
Gaudiot, Christopher
Gau, Susan Shur-Fen
Gavin, David P.
Gawrysiak, Michael
Gee, Steven
Geer, Eliza
Geha, Paul
Gelenberg, Alan
Geliebter, Allan
Geller, Daniel A.
Geng, Xiujuan
Gentil, Andre
Gentil, Valentin
George, Mark
George, Noble
George, Tony
Georgiou, Polymnia
German, Bruce
Gerretsen, Philip
239
166
226, 230, 234, 270
274
181
237
275
218, 276
267
214
278
147, 278
236
241
236
240
220
176
269
173
185
258
248
235
179, 213
265
171
189
199
159
223
196
217
272
210
225
279
188
240
219
183
212
208
198
247
261
115, 216, 221,
258, 261
225
186, 229
222
212
186, 187, 226
Geschwind, Daniel
Geske, Jennifer
Gess, Jennifer L.
Gether, Ulrik
Geyer, Mark
Ghahremani, Dara
Ghazzaoui, Rassil
Ghitza, Udi
Ghose, Dipanwita
Ghose, Subroto
Ghoshal, Ayan
Giangrande, Evan
Giannaris, Eustathia
Gibson, Greg
Giese, Maria
Gigi, Karny
Gilder, David
Gill, Kathryn
Gill, Michael
Gillespie, Charles
Gillougley, Claire
Gilman, Jodi
Gilmore, John
Gilpin, Nicholas
Gingrich, Jay
Gipson-Reichardt, Cassandra
Giraldez, Antonio
Girgis, Ragy
Giuliano, Chiara
Gizer, Ian
Gjeluci, Klaudio
Gladding, Robert
Glahn, David
Glaus, Jennifer
Glavis-Bloom, Courtney
Gleason, Ondria
Gleason, Scott
Glenthoj, Birte
Glober, Gordon
Glover, Matthew
Gluck, Rachel
Glusman, Chloe E.
Glynn, Ryan
Gobrogge, Kyle
Goddard, Simon
Godfrey, Jodi
Goeders, Nicholas
Goetter, Elizabeth
Goetz, Deborah
Goetz, Raymond
Gogos, Joseph
Gold, James
178, 262
214
184
162
104, 207, 247,
255, 269
239
66, 202
201
277
230
268
234
192
206
180
233
275
188
173
259
187
242, 275
144
208, 275
173
236, 241
223
24, 269
195
172
179, 213
172
77, 182, 232, 269
220
267, 274
216
185
234, 265
64, 182
170
259
261
278
238
171, 183
278
276
246
189
189, 193
229
187
304
11/10/15 9:59 AM
Gold, Lisa
Goldbach, Jacqueline R.
Goldberg, Alexander
Golden, Sam
Goldman, Aaron L.
Goldman, David
Goldsmith, David
Goldstein, Benjamin
Goldstein, Jill
Goldstein-Piekarski, Andrea
Goldstein, Rita
Goldwasser, Benjamin
Gollub, Randy
Gomes, Karina
Gomez, Adrian
Gomez, Angelina F.
Gómez-Cruz, Gladys
Gonen, Oded
Goodkind, Madeleine
Goodman, Marianne
Goodman, Michelle
Goodman, Wayne
Goodwin, Guy
Goonawardena, Anushka
Gopal, Srihari
Gopinath, Srinath
Gopin, Chaya
Gordon, Joshua
Gorenstein, Clarice
Goring, Harald
Gorka, Stephanie
Gorlich, Andreas
Gosden, Jane
Goshal, Ayan
Gotlib, Ian
Gould, Ian C.
Goulding, Evan
Gould, Todd
Gourley, Shannon
Gowin, Joshua
Gowrishankar, Raaj
Grace, Anthony
Graf, Radka
Graff, Ariel
Graff-Guerrero, Ariel
Grandy, David
Grant, Jon
Grant, Kathleen
Grant, Steven
107
193
21, 207
213, 276
245
117, 145, 154,
163, 181, 247,
264, 267
220
174
53, 60, 61, 165,
176, 180, 224, 227
219
2, 98, 195, 236,
238, 240, 275
235
232
214
253
208
269
258
207
186
186, 229
156
180
274
233
178
230
136
261
77, 182, 269
246
280
171, 183
245
219
227
179
205, 222
219
237
209
188, 215, 225, 258
191
186, 187, 226
269
2
172, 274
39, 201
115
Grassi-Oliveira, Rodrigo
Graur, Simona
Gravel, Paul
Graves, Mary
Grayson, Ben
Greco, Dario
Green, Alan
Green, Amanda
Green, Charles
Green, Melissa J.
Green, Michael
Green, Torrian
Greenberg, Benjamin
Greenberg, Jessica
Greenberg, Tsafrir
Greene, Robert
Greenwood, Tiffany
Gregory, Michael
Greguric, Ivan
Greif, Taylor
Gresch, Paul J.
Greve, Douglas
Grice, Dorothy
Griffiths, Roland
Grillon, Christian
Grilo, Carlos
Grimwood, Sarah
Grinevich, Valery
Grisot, Giorgia
Grissom, Nicola
Groman, Stephanie
Gross, Robert
Gross, Robin
Grosz, Daniel
Grubisha, Melanie
Gruene, Tina
Grueter, Brad
Grünbauer, Waltraud
Gründer, Gerhard
Grunebaum, Michael
Gu, Hong
Guercio, Leonardo
Guerguieva, Ralitza
Guevarra, Kimberly
Guido, Michael
Guidotti, Alessandro
Guilmette, Edward
Guise, Kevin
Gunn, Ben
Gunn, Roger
Guo, Jidong
Guo, Wei
Guo, Yin
210, 277
218
236
255
187
222
145, 211, 229
189
241
227
118, 227, 233
170
161, 246, 247
270
180, 218
2
258
224, 249, 251
214
222
237
231, 232, 248
249
157
206, 216
196
261
214
263
208, 210
212
258
189
199
187
206
132, 277
217
191
255
198
91, 195
177
199
197
192, 230
235
195
175
184
166
255
192
305
11/10/15 9:59 AM
Gupta, Aarti
Gupta, Arpana
Gupta, Cota Navin
Gupta, Swapnil
Gur, Raquel
Gur, Ruben
Gur, Tamar
Guranda, Mihail
Gurley, David
Gutierrez-Reed, Navarre
Gutman, Andrea
Guyer, Amanda
Guzman, Daniel
Haan, Lieuwe De
Haas, Magali
Haase, Lori
Haass-Koffler, Carolina
Haber, Ross
Haber, Suzanne
Hablitz, John
Hachigian, Lea
Haddad, Francois
Hagenauer, Megan
Haghighi, Mohammad
Hagihara, Hideo
Hagino, Yoko
Hahn, Britta
Hahn, Maureen
Haimovici, Florina
Hajos, Mihaly
Hakonarson, Hakon
Halberstadt, Adam
Halene, Tobias
Halladay, Lindsay
Hallam, M.
Hallberg, Jonas
Halldin, Christer
Halley, Paul
Hall, Frank
Hall, Janet
Hall, Martica
Hallmayer, Joachim
Halmi, Katherine
Halpern, Tamar
Hameed, Ahmad
Hamilton, Paul
Hamm, Alfons
Hammack, Sayamwong
Hammamieh, Rasha
Hammock, Bruce D.
241
263
232, 269
241
2, 18, 53, 104,
126, 211, 220,
228, 229
126, 200, 211,
220, 228, 229
211
237
265
183
241
250
198
266
104
264
101
240
2, 116, 161, 263
226, 270
263
183
173
176
227
195
184, 223
209
224
270
249
157, 269
126, 192
245
171
195
173
251
191, 200
175, 181
259
219
212
257
183
220
166
222
206
212
Hammond, Flora
Han, Buhm
Han, Ming-Hu
Han, Xiao
Haney, Margaret
Hanlon, Colleen
Hanna, Gregory
Hanna, Rebecca
Hannestad, Jonas
Hansen, Karina
Hansen, Rolf
Hansen, Stefan
Hantsoo, Liisa
Hardan, Antonio
Hariharan, Hari
Harkins, Elizabeth
Harlow, Sioban
Harman, Charles R.
Harmer, Catherine
Haroon, Ebrahim
Haroutunian, Vahram
Harrington, Anthony
Harris, Jonathan
Harris, Margret
Harris, Olivia
Harris, Paul
Harrison, Neil
Harrod, Steven
Harsányi, Judit
Harte, Mike
Hartmann, Jakob
Hartwell, Emily
Harvey, Alexander
Harvey, Brandon
Harvey, Eric
Harvey, Meredith
Harvey, Philip
Hasenkamp, Wendy
Hashemi, Parastoo
Hashimoto, Hitoshi
Hashimoto, Kenji
Hasler, Gregor
Hassoun, Youssef
Haswell, Courtney
Hatch, Ainslie
Hattori, Satoko
Hatzinger, Martin
Hauser, Michael
Hauser, Sheketha
Havekes, Robbert
Hawco, Colin
225
190
2, 68, 194, 256
238
66, 165, 198, 202,
205, 245
196, 258
246
230
197
232, 265
211
249
216
183
228
209
259
165, 205, 245
180
219, 220, 259
83, 194
48, 176
277
267
222
190
123
255
88, 194
187
214
237
223
196
280
207
165, 175, 189,
224, 226
189
162, 262
268
173
19, 32, 33, 34, 266
270
248
193
227
180
248
264, 277
208, 210
266
306
11/10/15 9:59 AM
Hayes, Lindsay
Hayes, Matthew
Hayton, Scott
Hazlett, Erin
Haznedar, Mehmet M.
He, Fanyin
He, Aiqing
Heal, David
Healey, Kati L.
Healy, Kaitlin
Heckers, Stephan
Heffernan, Joseph
Hegarty, Catherine
Hegarty, John
Heguy, Adriana
Heilbut, Adrian
Heilig, Markus
Heiman, Myriam
Heinemeyer, Erin
Heinsbroek, Jasper
Heisler, Lora
Heitzeg, Mary
Heller, Aaron
Heller, Elizabeth
Hellriegel, Josselyn
Hellrung, Lydia
Helmbold, Katrin
Helms, Christa
Hemby, Scott
Hemmelder, Vivian
Hemmeter, Ulrich
Hen, René
Henn, Fritz
Henna, Elena
Hennah, William
Henning, Anke
Henry, Mellissa
Herai, Roberto
Hermes, Gretchen
Hernández-Díaz, Sonia
Hernandez, John
Hernandez, Nicole
Herpertz, Sabine
Herrick, Scott
Herringa, Ryan
Hertel, Peter
Heshmati, Sara
Heyer, Mary
Hickie, Ian
Hider, Joanna
Higginbotham, Jessica
Higgins, Stephen
192
199
79, 184
186, 266, 267
266
228, 259
233
171, 183
199
245
104
182, 207
224, 251
251
189
263
110, 237
263
217
240, 241
245
147
20, 37, 38, 176
152, 178
166
27, 260
215
39, 201
192
30, 281
180
21, 155, 173, 207,
212, 254, 262
156
261
231
248
199
251
199, 270
216
239
199
264
71, 185
169
232, 265
235, 275
234
258
248
201
278
Higgs, Suzanne
175
High, Nellie
171
Higley, J. Dee
248
Hikida, Takatoshi
197
Hilker, Rikke
234
Hill, Mackenna
250
Hill, Matthew
221
Hill, S. Kristian
230
Hillard, Cecilia
221
Hillmer, Ansel
197
Hinkin, Charles
224
Hinkka-Yli-Salomäki, Susanna 171
Hipolito, Lucia
198
Hipwell, Alison
250
Hirano, Yoji
227
Hiroi, Noboru
148
Hnasko, Thomas
183
Ho, New Fei
231
Hodes, Georgia
213
Hodgins, Gabrielle
213
Hodgkinson, Colin
201, 247, 264, 267
Hoeppner, Susanne
198, 242
Hoexter, Marcelo
247, 248
Hof, Patrick
192
Hoffman, Ellen
223
Hoffman, Jessica
181
Hoffman, M. Camille
168
Holly, Elizabeth
238
Holmes, Andrew
196, 245
Holsboer-Trachsler, Edith
176, 180
Holsen, Laura
176, 180, 224
Holtzheimer, Paul
145, 149
Homann, Oliver
228
Honda, Sokichi
187
Hong, Elliot
119, 223, 272
Hong, Kwang-ik
199
Hooker, Jacob
71, 185, 230, 231
Hooper, Andrew
238
Hopson, Ryan
200
Horan, William P.
227, 233
Horga, Guillermo
20, 24, 41, 42, 43,
268, 269
Horsfall, Wendy
272
Horvath, Tamas
270
Hosmalin, Anne
269
Hough, David
233
Houle, Sylvain
190, 253
Hourguettes, Nick
274
Hovatta, Iiris
222
Hovav, Sarit
221
Hove, Michael
249
Howe, William
235
Howell, Leonard
167
307
11/10/15 9:59 AM
Howes, Oliver
Howlett, Jonathon
Hoxha, Eriola
Hsu, Benjamin
Hsu, David
Hsu, Jay
Hsu, Yun-Wei
Hu, Sien
Hu, Xiaoping
Hu, Yuzheng
Huang, Freesia
Huang, He
Huang, Kuo-Ping
Huang, Xiaojie
Huang, Yiyun
Hudson, Courtney
Hudson, James
Hughes, Erica
Hughes, Zoe
Huhn, Andrew
Hultman, Christina
Hulvershorn, Leslie
Hummer, Tom
Hunter, Sharon
Huntley, George
Huo, Zhiguang
Hurlemann, Rene
Husain, Mustafa
Hutchison, Kent
Hutchison, Matthew
Hutson, Peter
Huynh, Kevin
Huynh, Polly
Huynh, Win Thuy-uyen
Hyde, Thomas
Iacoviello, Brian
Iadarola, Michael
Iadarola, Nicolas
Ianni, Angela
Ibanez-Tallon, Ines
Ibi, Daisuke
Ibrahim, Ibtihal
Icay, Katherine
Idy, Erick
Ihne, Jessica
Iijima, Michihiko
Ikeda, Kazutaka
Ikuta, Toshikazu
Iliff, Jeffrey
Inagaki, Hidehito
Inbar, Benjamin
Ingelman-Sundberg, Magnus
111, 270
207
266
181
140, 182
172, 268
213
239
219, 259
198
227
207
227
178
276
202
168, 171
190
191
277
192
254
272
168
120
233
184, 207, 264
174, 209
163, 280
271
171
77, 182
193
232
212, 223, 231,
232, 249
221
213, 264
215
224, 251
280
228
126
222
168
179
176
195
230
108
227
190
173
Iniguez, Sergio
Innis, Robert
Insel, Crystal
Inserra, Antonio
Ioannidis, Konstantinos
Ionescu, Dawn
Iosif, Ana-Maria
Iosifescu, Dan
Irimia, Cristina
Irungu, Benson
Ishikawa, Masago
Ishikawa, Rie
Islam, Rehnuma
Issa, Omar
Issler, Orna
Itou, Taichi
Ivanov, Iliyan
Ivleva, Elena
Jaaro-Peled, Hanna
Jabbi, Mbemba
Jackson, Nateka
Jacob, Arpitha
Jacobs, Emily
Jacobson, William
Jacobus, Joanna
Jaffe, Andrew
Jagannathan, Kanchana
Jagnarine, Darin
Jahangard, Leila
Jaitly, Nina
Jakubovski, Ewgeni
James, G. Andrew
James, George
James, Thomas F.
Janak, Patricia
Jangir, Vinod Kumar
Janicak, Philip
Janik, Adam
Janjua, Khurram
Janowsky, David
Jardemark, Kent
Jasberg, Suzanne
Javidfar, Behnam
Javitch, Jonathan
Javitt, Daniel
Jayathilake, Karu
Jay, Therese
Jedynak, Jakub
Jeevakumar, Vivek
Jenko, Kimberly
Jensen, J. Eric
Jensen, Leah
173, 276
2, 19, 35, 36, 142,
172, 177, 182, 230
249
214
172
179, 182
273
221, 255, 260
279
181
234
184
272
200
178
197
147
230
192
224
170
267
165
175
168
99, 223, 232, 249
279
235
176
175
257
184
254
266
196
208
221
233
205
254
191
273
228
189, 190, 229
137, 226, 234, 258
267
269
279
226, 230
172
168
276
308
11/10/15 9:59 AM
Jensen, Maria
Jeon-Slaughter, Haekyung
Jett, Marti
Jia, Chen
Jia, Yankai
Jia, Yun-Fang
Jiang, Cheng
Jiang, Shan
Jiang, Xiaohui
Jiang, Yan
Jiang, You-ming
Jiao, Huifeng
Jimenez, Daniel
Jimenez, Jessica
Jin, Hua
Jin, Jian
Jin, Peng
Jin, Yunju
Jo, Booil
Jobes, Michelle
Joffe, Hadine
Johannesen, Jason
Johayem, Anass
John, Majnu
John, William
Johnson, Alex
Johnson, Jacqueline
Johnson, Philip
Johnson, Sarah
Johnson, William
Johnstone, Andrea
Johnstone, Tom
Jokinen, Jussi
Jones, Maile
Jones, Sara
Jones, Stephanie
Jones, Thomas
Jope, Richard
Joseph, Victory
Joshi, Dankesh
Joshi, Sonalee
Jovanovic, Tanja
Juarez, Barbara
Jung, Moon
Jutkiewicz, Emily
Kahler, Anna
Kahn, Rene
Kaiser, Roselinde
Kaiser, Ursula
Kalak, Nadeem
Kalali, Amir
Kalin, Ned
Kaliora, Styliani
234
174
206
196
232
214
68, 194
252
218
192, 228
211
266
165
19, 21, 22, 23, 207
192
268
206
262
184
201
181
272
32, 266
230, 234, 270
242
183
220
247
214
197
110
37, 176
195
177
39, 197, 201
211
189
257
48, 176
200
250
102, 166, 259, 264
68, 194, 256
220
246
192
63, 88, 89, 90, 194
149
208
176
262
37, 176, 246
255
Kalivas, Peter
Kalk, Nicola
Kamath, Jayesh
Kameyama, Toshiki
Kamiya, Atsushi
Kanba, Shigenobu
Kane, John
Kanekar, Shami
Kangarlu, Alayar
Kano, Shin-ichi
Kantrowitz, Joshua
Kao, Charlly
Kaplan, Claire
Kaplan, Keren Grosman
Karameh, Fadi
Karayiorgou, Maria
Karlawish, Jason
Karlsgodt, Katherine
Karl, Tim
Karne, Harish
Karp, Jordan
Kasahara, Yoshiyuki
Kasai, Shinya
Kash, Thomas
Kaska, Sophia
Kasparek, Steven
Kass, Joanna
Kassir, Suham
Kasthelyan, Vadim
Kato, Akihiko
Katsuki, Fumi
Katz, Jonathan
Katzka, William
Kauer, Julie
Kaufman, Marc
Kaur, Navneet
Kaye, Walter
Kearney-Ramos, Tonisha E.
Kechner, Megan
Keedy, Sarah
Keefe, Richard
Keenan, Kate
Kegeles, Lawrence
Keiser, Michael
Keita, Hamidou
Kelleher, Shannon
Kellendonk, Christoph
Kellner, Charles
Kelly, Deanna L.
Kelly, Kyle
Kelly, Ryan
Kelsoe, John
2, 53, 120, 236,
240, 241, 276
270
262
227
265
227
230, 234, 270
219, 238
258
184
226
249
233
248
182, 258
229
171
2, 226, 230, 234
139
254
100
191
195
236, 245, 253
197
196
229
254
195
185
227
189
215
240
168
257
171, 212, 251
184
197
225
262
250
66, 202
192
246
180
190
270
189
245
227
258
309
11/10/15 9:59 AM
Kempf, Janina
Kenk, Miran
Kennedy, James
Kennedy, Pamela
Kennedy, Robert
Kennedy, Sidney
Kenny, Paul
Kent, Jack
Kent, Justine
Kerley, Kimberly
Kerman, Ilan
Kern, Robert S.
Kerns, Suzanne
Kerr, Kara
Kerwin, Robert
Keshavan, Matcheri
Kesheviah, Aparna
Kessler, Daniel
Keyes, Megan
Khalesi, Zahra
Khalsa, Dharma
Khalsa, Sahib
Khan, Arif
Kheirbek, Mazen
Khlghatyan, Jivan
Khokhar, Jibran
Kida, Satoshi
Kidd, Brian
Kieffer, Brigitte
Kilaru, Varun
Kilduff, Thomas
Killgore, William
Kilts, Clinton
Kim, Chul-Hoon
Kim, Jae Mun
Kim, Pilyoung
Kim, Scott
Kim, Semmie
Kim, Suck Won
Kim, Tae-Kyung
Kim, Ye Ji
Kim, Youngsoo
Kindberg, Abigail
Kindler, Jochen
King, Andrea
King, Anthony
King, Mary-Claire
King, Oliver
Kingslake, Jonathan
Kingsley, Peter
Kinirons, Mark
Kinkead, Becky
Kippenhan, J. Shane
215
190
178, 190, 251, 256
280
253
256
192, 234
77, 182, 269
181
264
215
233
216
222
173
122, 230, 267, 271
168
206
189
248
165
207, 264
177
21, 207, 262
174
211, 229
184
192
155
189
274
179
168, 184, 254
262
246
170
171
181
199
278
166
183
196
46, 186
199, 237
166
94, 95, 96
271
180
255
173
169
224, 249
Kippin, Tod
Kircanski, Katharina
Kircher, Tilo
Kirkpatrick, Stacey
Kirschen, Jill
Kirschmann, Erin
Kirschner, Heather
Kissler, Jessica
Klei, Lambertus
Kleinman, Joel
Klengel, Torsten
Klibanski, Anne
Klimes-Dougan, Bonnie
Kline, Chris
Knackstedt, Lori
Knickmeyer, Rebecca
Knight, Christopher
Knight, Jo
Knowland, Daniel
Knowles, Emma
Knowles, James A.
Knowlton, Barbara J.
Knudsen, Gitte
Kober, Hedy
Kochunov, Peter
Kodi, Priyadurga
Koek, Wouter
Koenen, Karestan
Koenigsberg, Harold
Koen, Nastassja
Koesters, Thomas
Koethe, Dagmar
Koga, Minori
Kohno, Milky
Kohn, Philip
Koike, Hiroyuki
Koike, Nobuya
Kojori, Ehsan Shokri
Kokkinos, Peter
Kolarz, Adam
Kolb, Hartmuth
Kolden, Greg
Kole, Loren
Kolivakis, Theo
Kolla, Nathan
Konkalmatt, Prasad
Konopaske, Glenn
Konova, Anna
Konradsson-Geuken, Åsa
Koob, George
Koola, Maju
202
213
166
197
228
196
223
280
249
144, 212, 223,
231, 232, 249
168, 206
165
210
259
196, 275
130
264, 277
190
270
62, 77, 78, 182,
269
246
233
184
196
223, 269, 272
272
214
206
186
206
185
264
265
239
224, 249, 251
188
278
276
191
214
177, 218, 225
37, 176
197
200
186
276
192
195, 236
191
18, 104, 126
173
310
11/10/15 9:59 AM
Korenic, Stephanie
Korgaonkar, Mayuresh S.
Korosi, Aniko
Korth, Carsten
Koshy-Cherian, Ajeesh
Kostic, Dusan
Kosyk, Oksana
Koustova, Elena
Kovacs, Zsofia
Kowalczyk, William
Kowalski, Cody
Kozak, Rouba
Kozicz, Tamas
Kozlenkov, Alexey
Krack, Paul
Kraguljac, Nina
Kramer, Tatyana
Kramer, Teresa
Kranzler, Henry
Kranz, Thorsten
Krashes, Michael
Krause-Heuer, Anwen M.
Kravitz, Howard
Krebs, Marie-Odile
Kreek, Mary Jeanne
Kreuzman, Drew
Krishnamurthy, Venkatagiri
Krishnamurthy, Venkatesh
Kroemer, Nils
Kroener, Sven
Kroll-Desrosiers, Aimee
Krystal, John
Ku, Stacy
Kubicki, Marek
Kucyi, Aaron
Kuehne, Claudia
Kuei, Chester
Kugel, Harald
Kuhn, Cynthia
Kuhn, Taylor
Kuhney, Franchesca
Kulicke, Ruth
Kumar, Anand
Kumar, Jaswinder
Kumar, Manoj
Kumra, Sanjiv
Kundu, Prantik
Kunwar, Pratap
Kupchik, Yonatan
Kupfer, David J.
Kurahashi, Hiroki
Kuroiwa, Mahomi
Kuwabara, Hiroto
223
219
252
231
183
177
180
104
278
201
251
235
245
192
274
63, 86, 87, 194
262
168
163
189, 193
253
214
259
269
179
196
278
183
101
230
175
167, 174
68, 194, 256
234
249
214
48, 176
167
135, 249, 256
224
223
263
185, 222
278, 279
208
238, 239
263, 274
248
241
2
227
197
225
Kwa, Lauren
Kwako, Laura
Kyzar, Evan
Labate, Demetrio
Labus, Jennifer
Lachman, Herbert
Laezza, Fernanda
Lagzdins, Dina
Lahti, Adrienne
Laird, Angela
Lajtha, Abel
Lalazar, Yelena
LaLumiere, Ryan
Lamar, Melissa
Lambert, Guerline
Lamers, Femke
Lancaster, Sarah
Land, Benjamin
Landino, Samantha
Landry, Donald
Lane, Rosanne
Lane, Scott
Lang, Thomas
Langbaum, Jessica
Langenecker, Scott
Langen, Karl-Josef
Langleben, Daniel
Langlois, Carolyn
Lanius, Ruth
Lapidus, Kyle
Larcher, Kevin
Laredo, Sarah
Large, Charles
Larsen, Bridget
Lasko, Natasha
Laszlovszky, István
Latapy, Camille
Latham, Patricia
Lavin, Antonieta
Lavretsky, Helen
Law, Amanda
Lazar, Mariana
Lazenka, Matthew
Lazzaro, John
Leaver, Amber
LeBeau, Fiona
Leckman, James
Ledon, Fred
LeDoux, Joseph
Lee, Chun-Ting
Lee, Daeyeol
Lee, Francis
Lee, Grace
183
154
277
266
263
228
266
237
86, 194, 267
236
192
240
159, 241
185
251
253
248
252, 253, 255
231
229
253
241
166
171
149, 222
215
200, 279
171
150
260
200
279
187
224
261
88, 194, 229
174
275
198
165
2, 144, 168
258
235
261
165
187
129
225
166, 252
196
212
2, 124
48, 176
311
11/10/15 9:59 AM
Lee, Hyo Jong
Lee, Joel T.
Lee, Junghee
Lee, Mary R.
Lee, Royce
Lee, Soomin
Lee, Suhyun
Lee, Wayne
Leger, Marianne
Legget, Kristina
Leggio, Lorenzo
Legind, Christian
Lehrfeld, Jonathan
Leibenluft, Ellen
Leite, Claudia
Lemos, Julia
Lencz, Todd
Lennartsson, Andreas
Lenroot, Rhoshel
Lenz, Jeffrey
Leonard, Sherry
Leong, Lex
León-Ortiz, Pablo
Leon, Rosa
Leow, Alex
Lepack, Ashley
Lepage, Martin
Leppink, Eric
Lepsien, Jöran
Lerch, Jason
Lerman, Caryn
Lesage, Elise
Lescalette, Adam
Leserman, Jane
Lesh, Tyler
Leslie, Kimberly
Lessard, Andree
Letavic, Michael
Leung, Ming
Leussis, Melanie Leussis
Levandowski, Mateus
Levin-Gleba, Laura
Levinson, Andrea
Levis, Sophia
Levitan, Robert
Levitt, James
Leweke, F. Markus
Lewis, Charles
Lewis, David
Lewis, Martin
Lewis, Michael
232
205
233
281
225, 237, 252
231
213
210
187
262, 269
101, 201, 281
234
226
134, 209, 213
248, 261
260
226, 230, 255,
270, 273
175
46, 186
197
168
214
269
255
215, 222, 252
263
266
172
27, 260
209, 210
200
241
269
220
229
167
192
218
264
179
277
169
259
208
253
169
264
209
2, 185, 191, 193,
233, 273
213, 214
280
Lewison, Barbara
Lewis, Yvonne
Leyton, Marco
Lezak, Kim
Li, Cheng-Ta
Li, Chiang-shan
Li, Dayong
Li, Haitao
Li, Jiang
Li, Jun
Li, Jun-Xu
Li, Ka-Wan
Li, Li
Li, Qingqin
Li, Rachel
Li, Rui
Li, Wei
Li, Xingbao
Li, Yifan
Li, Yujing
LI, Zhihao
Liberzon, Israel
Libove, Robin
Licinio, Julio
Lieberman, Jeffrey
Liffick, Emily
Light, Gregory
Lim, Byungkook
Lim, Jackie
Lim, Kelvin
Lim, Pilar
Lim, Sean
Limon, Agenor
Limon-Ruiz, Agenor
Lin, Cong
Lin, Hsiang-Yuan
Lin, Jue
Lin, Katie Watson
Lin, Shih-Ku
Lin, Shu-Fei
Lin, Wei-Chen
Lin, Yingxi
Lindefors, Nils
Lindell, Stephen
Linden, David
Linden, Maike
Lindsley, Craig
Link, Katherine
Liow, Jeih-San
Lipska, Barbara
Lisanby, Sarah
189
184
200, 236
222
233
239
229
263
266, 268
173
277
231
217
48, 176, 216
213
229
207
258
272
206
259
166, 170, 207,
246, 250
183
213, 214
24, 269
272
117, 190, 226, 272
79, 184
197
161, 210, 232,
238, 239, 260, 273
220
173
211
256
192
210
177
177
186
197
233
278
173
248, 264
262
215
189, 245, 268
178
35, 36, 182
230
174, 254
312
11/10/15 9:59 AM
Lissemore, Jennifer
Litman, Robert
Litten, Raye
Liu, Changlu
Liu, Chunyu
Liu, Fang
Liu, Hesheng
Liu, Jiabei
Liu, Jianfeng
Liu, Jingyu
Liu, Rong-Jian
Liu, Tina
Liu, Tom
Liu, Xiaochuan
Liu, Yanni
Llerena, Katiah
Lo, Brian
Lobo, Daniela
Lobo, Mary Kay
Lochner, Christine
Lockovich, Jeanette
Loebel, Antony
Logan, Jean
Logan, Ryan
Loheswaran, Genane
Loi, Barbara
London, Edythe
Lopes, Antonio
Lopez-Guzman, Silvia
Lopez, Leonardo
Lopez-Quintero, Catalina
Lori, Adriana
Lorsch, Zachary
Losen, Dominique
Lotarski, Susan
Loughead, James
Lovenberg, Timothy
Love, Raymond C.
Love, Tiffany
Lovinger, David
Lowe, David
Lowell, Bradford
Lowen, Steve
Loweth, Jessica
Lowey, Rachel
Loze, Jean-Yves
Lu, Kaifeng
Lu, Yang
Luber, Bruce
Luckenbaugh, David
Lucki, Irwin
Luck, Robert
236
268
200
48, 176
126
266
161, 222
220
277
232
194
247
171
178
246
227
184
261
173, 222, 276
172
180, 218
172, 189, 214,
218, 221, 252, 268
185
185, 241
229, 235
240
147, 195, 239
247, 248
236
270
200
206, 264
178, 213
246
261
200
48, 153, 176
189
182
39, 197, 201
263
208, 253
200
278
44, 188
232, 265
187, 194, 229
263
174
215
100, 255
64, 182
Lukas, Scott
Lukkes, Jodi
Lundberg, Johan
Luscher, Christian
Lussier, Stephanie
Lustenberger, Caroline
Lustig, Cindy
Luthringer, Remy
Lutter, Michael
Lutz, Joseph
Ly, Huy
Lyall, Amanda
Lyons, Samantha
Ma, Min
Ma, Sean
Ma, Tianzhou
Ma, Yina
Mabrouk, Omar
Macaluso, Matt
MacDonald, Matthew
Machado-Vieira, Rodrigo
Maciukiewicz, Malgorzata
Mackey, Lester
Mackey, Scott
Mackey, Sean
MacKillop, James
Macleod, Malcolm
Macpherson, Tom
Mactutus, Charles
Madras, Bertha
Maffei, Antonella
Maguire, Caroline
Maguire, Jamie
Maher, Brady
Maher, Steve
Mahler, Stephen
Mahmood, Zanjbeel
Mahoui, Asmaa
Mahr, Marina
Maier, Wolfgang
Maihofer, Adam
Makotkine, Iouri
Makris, Nikos
Malaker, Pias
Malaspina, Dolores
Malchow, Berend
Malenka, Robert
Malhotra, Anil
Malur, Chitra
Mamdani, Firoza
Mamo, David
189, 277
250
173
160
169
233
183
263
138
236
174
234
235
173
207
185
274
253
216
97, 193, 273
177, 206, 215, 255
256
219
121, 278
115
112
104
197
255
240, 261
190
208
238
151, 265
189
275
224
247
166
184
207
240
169, 257
236
189, 193
188
2, 79, 184
2, 215, 226, 230,
234, 255, 270,
272, 273
234
256
186, 187, 226
313
11/10/15 9:59 AM
Mamoun, Michael
Mancino, Michael
Mandelkern, Mark
Mandl, René
Mandyam, Chitra
Mandy, William
Manfro, Gisele
Manji, Husseini
Mann, J.
Mannes, Andrew
Manning, Claire
Manoach, Dara
Mansari, Mostafa El
Mansky, Benjamin
Mantsch, John
Mao, Xiangling
Mao, Yongcai
Maoz, Keren
Mar, Wanna
Marchant, Gary
Marchetto, Maria
Marcinkiewcz, Catherine
Marcinno, Andrea
Marcus, Monica
Marder, Stephen
Mareckova, Klara
Marenco, Stefano
Maren, Stephen
Margaret, Haney
Margolis, Amy
Margolis, Elyssa
Margolis, Jeffrey
Marietta, Cheryl
Marin, Marie-France
Marino, Brielle
Mariot, Edemilson
Markou, Athina
Marmar, Charles
Marreiros, Rita
Marshe, Victoria
Marsh, Rachel
Marsit, Camen
Martens, Gerard
Martin, Clair
Martin, David
Martinez, Antigona
Martinez, Diana
Martinez, Emily
Martinez, Pedro
Martini, Brenda
Martinowich, Keri
Martorelli, Mariella
Marx, Christine
240
238
195, 239, 240
234
239
166
171
181, 220, 268
254
213, 264
216
231
217, 256
196
274
260
172, 218, 221
209
186, 187, 226
171
151
245, 253
266
191
2, 187
176, 180
227
246
281
260
196
178
181
247, 260, 261
228
254
259
206
231
256
172
170
213
179
231
234
98, 281
222
181
167
2, 232
240
248
Masdeu, Joseph
Maseo, Javier
Mashhoon, Yasmin
Masneuf, Sophie
Mason, Barbara
Massaly, Nicolas
Masters, Grace
Mastronardi, Claudio
Mateo, Yolanda
Mates, Sharon
Mathalon, Daniel
Mathe, Aleksander
Mathew, Sanjay
Mathews, Carol
Mathias, Samuel R.
Mathur, Anil
Mathur, Brian
Matosin, Natalie
Matricon, Julien
Matsumoto, Mickey
Matsumoto, Naomich
Mattay, Raghav
Mattay, Venkata
Matthews, Alicia
Matthews, Karen
Matthews, Mark
Mattiuz, Sanela
Matuskey, David
Maurer, John
Maurya, Pawan
May, Victor
Mayberg, Helen
Mayer, Andrew
Mayer, Emeran
Mayer, Stefanie
Mayfield, Dayne
Maynard, Kristen
Mayoral, Maria
Maysami, Samaneh
Mayson, Sarah Jo
Maze, Ian
Mazei-Robison, Michelle
Mazumdar, Sati
Mazzone, Chris
McAdams, Carrie
McAllister, A. Kimberley
McBride, William
McCall, Jordan
McCarley, Robert
McCarthy, Lizbeth
McCarthy, Margaret
224, 251
228
189
196
2, 154
198, 237
271, 273
213, 214
39, 197, 201
267, 268
2, 44, 188, 232,
271, 272
175, 257
177, 255, 260
124
269
225
223
227
269
153, 187
170
224
223, 232, 245,
265, 274
199
259
181
192
174
199
277
222
145, 156, 258
232
263
173
110
232
250
187
186
178, 263
197, 216
228
245
138, 182
273
264, 277
253
227
168
114, 222
314
11/10/15 9:59 AM
McClain, Lora
McClellan, Jon
McClintock, Shawn
McClung, Colleen
McCollum, Lesley
McComas, Megan
McConnell, Patrick
McCorvy, John
McCoy, Chelsea
McCullumsmith, Robert
McDonnell, Sue
McDonough, Stefan
McDuffie, James
McElligott, Zoe
McElroy, Susan
McEwen, Bruce
McEwen, Sarah
McGary, Colleen
McGinn, Adrienne
McGlade, Erin
McGlashan, Thomas
McGlinchey, Ellen
McGonigal, Justin
McGowan, Josephine
McGregor, Ainsley
McGuffin, Peter
McGuire, Joseph F.
Mcguire, Philip
McHenry, Jenna
McInnis, Melvin
McKay, Reese
McKee, Sarah
McKee, Sherry
McKenna, James
McKie, Shane McKie
McKinney, Brandon
McLaughlin, Ryan
McLeod, Cody
McMahon, Francis
McMahon, Robert P.
McMaster, Antonia
McMeekin, Laura J.
McNally, James
McNamara, Margaret
McNamara, Patrick
McNamara, Robert
McNutt, Marcia
McQuail, Joseph
McQuoid, Douglas
McTeague, Lisa
Meador-Woodruff, James
Meaney, Michael J.
Meccia, Juliet
223
141
174, 254
2, 185, 241
190
223
167
188
170
234
264
228
218
180
171, 214
7, 8, 9, 221, 257
232
175
275
218
271, 272
238
199
173
251
173
208
270
180
222
269
208, 210
179
227
187
193
251, 257
238
119, 215, 255, 259
189
186
270
227
186
199
176
224
245
221
258
2, 83, 194
254
193
Medina, Adriana
Mehdiyoun, Nikki
Mehta, Neil
Mei, Lin
Meikle, Peter
Mejias-Aponte, Carlos
Melanson, Edward
Melchior, James
Melendez, Gilia
Mellin, Juliann
Melman, Caroline
Meloni, Edward
Melrose, A. James
Meltzer-Brody, Samantha
Meltzer, Herbert
Meltzer, Peter
Menard, François
Menard, William
Mendelowitz, Alan
Mendez-David, Indira
Mentch, Frank
Menzaghi, Frederique
Merchenthaler, Istvan
Mercken, Marc
Merfeld, Emily
Merikangas, Alison K.
Merikangas, Kathleen
Merikle, Elizabeth
Meruelo, Alejandro
Mervis, Carolyn
Mesholam-Gately, Raquelle
Meyer, Christian T.
Meyer, Francisca
Meyer, Jeffrey
Meyer, Matt
Meyer, Roger
Meyer, Stephanie
Meyer, Urs
Micci, Luca
Michaels, Tania
Michopoulos, Vasiliki
Mickey, Brian
Miczek, Klaus
Mielnik, Catharine
Mietlicki-Baase, Elizabeth
Miguel, Euripedes
Mihara, Takuma
Milad, Mohammed
Milella, Michele S.
Milenkovic, Marija
Milham, Michael
Miliano, Cristina
217
272
251
266
77, 182
195
262
39, 201
232
233
220
221
212
220
266, 267, 268, 273
261
180
168
234
173
249
183
222
225
265
220
206, 220, 258
175
168
249
227
227
213
142, 186, 221, 253
216
98, 183, 277
263
111
175
179
81, 182, 259, 278
182
238
272
199
171, 247, 248
187
102, 114, 246,
247, 260, 261
236
272
210, 250
240, 280
315
11/10/15 9:59 AM
Milienne-Petiot, Morgane
Miller, Andrew
Miller, Brittney
Miller-Cruse, Isaac
Miller, Earl
Miller, Melissa
Miller, Sarah
Millett, Caitlin
Minami, Haruka
Minassian, Arpi
Mineur, Yann
Minichino, Amedeo
Minn, Il
Mirnics, Karoly
Mischoulon, David
Mishina, Masayoshi
Mishra, Devesh
Missig, Galen
Misura, Kira
Mitchell, Amanda
Mitchell, Luke
Mitchell, Michael
Mitchell, Suzanne
Mitelman, Serge
Mithoefer, Oliver
Mittendorfer-Rutz, Ellenor
Miyakawa, Tsuyoshi
Miyauchi, Masanori
Mizrahi, Romina
Mo, Shunyan
Moberg, Paul
Modabbernia, Amirhossein
Moeller, Scott
Moghaddam, Bita
Mohr, David
Molet, Jenny
Molina, Juan
Mollon, Josephine
Molosh, Andrei
Momenan, Reza
Monge, Zach
Monteiro, Isabel
Montesino, Michael
Moondra, Priyanka
Moore, Holly
Moore, Kelsey
Moore, Rema
Moore, Tyler
Moorman, David
Morales, Angelica
Morales, Gustavo Franca
255
123, 219, 220,
253, 259
189
264
178
237
188
180
217
207
179
271
224
2
131, 174
195
198
222
228
192, 228
208
183
112
266
196
188
227
273
111, 190
175
228
249, 266
195, 236, 238,
240, 275
2, 19, 20, 241
179
175, 252
233
266
247
242
279
205
260
224
24, 41, 268, 269
209
217
211
239, 260
239
271
Morales, Marisela
Morales, Roberto
Moran, Jennifer
Moran, Lyndsey
Moran, Sean
Moreines, Jared
Moreira, José C.
Morel, Carole
Moreno, Carmen
Moreno, Miguel
Moreno-Ortega, Marta
Morey, Rajendra
Morgan, Ling
Morgenstern, Travis
Mori, Norio
Mori, Susumu
Morilak, David
Morishita, Hirofumi
Morisseau, Christophe
Morita, Makiko
Moritz, Amy
Moroco, Annie
Moron-Concepcion, Jose
Morris, Laurel
Morrison, Randall
Morrissey, Judy
Morrone, Maurilio da Silva
Morrow, Jonathan
Morse, Cheryl
Mortazavi, Ali
Mortimer, Niall
Moscarello, Justin
Mosconi, Matthew
Mose, Tenna
Moss, Stephen
Mousa, Awni
Moustafa, Danna
Mueller, Bryon
Mueller, Daniel
Mueller, Juliane K.
Mueller, Toni
Mueller, Walter
Muheim, Flavio
Muir, Tom
Mulholland, Patrick
Mullins, Casey
Mulsant, Benoit
Munafo, Marcus
Munoz, Adam
Munro, Cynthia
Muotri, Alysson
Murphy, Lauren
195
239
192
248
268
215
210
68, 194
250
250
258
143, 248
256
190
170
272
74, 168
188
212
197
189
191
198, 237
274
218
199
210
279
172
252
210
166
211
179
265
280
216
210, 232
117, 165, 205,
245, 256
264
63, 83, 84, 85, 194
245
180
263
199
222
186, 187, 226
209
259
224
251
169
316
11/10/15 9:59 AM
Murphy, Tanya
Murray, Heather
Murray, Jennifer
Murray, Nicole
Murray, Susan
Murrough, James
Muskiewicz, Dawn
Musselman, Dominique
Mwangi, Benson
Myrick, Hugh
Nabel, Elisa
Naber, Dieter
Nabulsi, Nabeel
Nader, Michael
Nagano-Saito, Atsuko
Nagarajan, Vidhya
Nagy, David
Nahas, Ziad
Naiberg, Melanie
Nakajima, Shinichiro
Nakamura, Kazuhiko
Nakamura, Richard
Nakao, Kazuhito
Nakazawa, Kazu
Nakonezny, Paul
Nam, Hyungwoo
Namboodiri, Vijay Mohan
Namburi, Praneeth
Nandi, Ayon
Nanga, Ravi Prakash Reddy
Napadow, Vitaly
Naraine, Melissa
Narayanan, Sreedharan
Narayan, Vaibhav
Nardi, Tatiana De
Narr, Katherine
Nasca, Carla
Nash, Tiffany
Nasrallah, Henry
Nathan, Pradeep
Nautiyal, Katherine
Navarra, Rachel
Navrotskaya, Valeriya
Naylor, Magdalena
Nazeri, Arash
Nebel, Rebecca
Nectow, Alexander
Negraes, Priscilla
Negus, Sidney
Neigh, Gretchen
Neill, Jo
Neisewander, Janet
208
81, 182
195
274
212
165, 205, 219,
221, 245, 255, 260
200
224
219
275
188
232, 265
197
242
236
196
270
182, 216, 258
174
186, 187, 226
170
18
226
226
169, 209
215
180
64, 182
225
228
176
270
238
216
277
165
257
224, 249
194, 229
170
212
208
205
165
209, 210
228
68, 194
251
235, 240
175
187
278
Nelson, Brent
Nelson, J. Craig
Nelson, Paul
Nemeroff, Charles
Németh, György
Nenov, Miroslav N.
Nepomuceno, Diane
Neri, Eric
Nery, Fabiano
Nestadt, Gerald
Nestler, Eric
Neugebauer, Nichole
Neumaier, John
Neumeister, Alexander
Neve, Rachel
New, Antonia
Newbould, Rexford
Newcomer, John
Newell, Dominick
Newell, Kelly A.
Newhouse, Paul
Newman, Amy
Newport, D. Jeffrey
Newsom, Ryan
Newton, Dwight
Nguyen, Dana
Nguyen, Elizabeth
Nguyen, Hien
Nguyen, Joseph
Nguyen-Louie, Tam
Nichols, Charles
Nichols, David
Nichols, Nona
Niciu, Mark
Nickerson, Lisa
Nickl-Jockschat, Thomas
Nicol, Ginger
Nicolas, Carruthers
Nieman, Lynnette
Niendam, Tara
Nierenberg, Andrew
Nievergelt, Caroline
Niggli, Markus
Nikosjkov, Andrej
Nimgaonkar, Vishwajit
Nisenbaum, Eric
Nishi, Akinori
Nishikawa, Toru
Nisonger, Sarah
Nitenson, Adam
Niwa, Minae
Nizam, Houda
273
218
228
213
88, 194
266
48, 176
184
220
225
178, 195, 213
273
252
276
178, 213
186, 264, 267
184
250
234
227
165
242, 281
213
208
174
232
258
175
246
168
231
157
86, 194
177, 215
277, 278
208, 210
250
48, 176
181
229, 273
172, 178, 221
207, 247
217
175
126, 223, 228,
267, 271
185
197
133
223
231
192, 197
238
317
11/10/15 9:59 AM
Niznikiewicz, Margaret
Nobrega, Jose
Noel, Nadine
Nomikos, George
Nomura, Hiroshi
Nørbak-Emig, Henrik
Nordström, Peter
Norman, Kevin
Norrholm, Seth
Northoff, Georg
Notarangelo, Francesca M.
Notzon, Swantje
Nouriani, Bita
Nuamah, Isaac
Nuechterlein, Keith H.
Nueten, Luc Van
Nugent, Allison
Nunes, Eric
Nutt, David
Nwabuisi-Heath, Evelyn
Nye, Jeffrey
Nygard, Stephanie
Nylander, Anna-Greta
Oathes, Desmond
Öberg, Katarina
Oborny, Samantha
O’Brien, Charles
Ochoa, Jesus
O’Connell, Patrick
O’Connor, Kevin
O’Connor, Mary-Frances
Odlaug, Brian
O’Donnell, James
O’Donnell, Patricio
O’Donovan, Aoife
O’Donovan, Bernadette
Odonovan, Sinead
Ogasa, Masaaki
Ogden, Todd
Oginsky, Max
O’Gorman, Cedric
O’Halloran, Rafael
O’Hara, Ruth
Ohri, Shaunak
Ohtani, Yoshikazu
Ojeil, Najate
Okada, Go
Okamoto, Yasumasa
Okita, Kyoji
Okon-Singer, Hadas
Oler, Jonathan A.
Olfson, Mark
227, 272
253
263
175
180
265
195
250
102
190
223
167
184
233
233
220
179, 215
253
184
230
216
274
232, 265
207
195
230
200, 279
280
248
197
140
172
178, 211
104, 117, 158,
188, 190
182
274
234
189
260
246
267, 268
236
217
185
265
24, 66, 202, 269
215
215
195, 239
27, 260
246
277
Olincy, Ann
Oller, D. Kimbrough
Olsen, Christina Kurre
Olson, Elizabeth
Olson, Paul
Olvera, Rene
Olvera, Rene L.
O’Malley, Stephanie
Ombach, Hendrik
O’Neal, Timothy
O’Neill, Casey
Ongur, Dost
Onitsuka, Toshiaki
Oosterhof, Chris A.
Oquendo, Maria
Oragunye, Njideka
Ordek, Gokhan
Orederu, Temidayo
Orel, Jennifer
Oribe, Naoya
Orlowski, Barbara
O’Rourke, Nancy
Orr, Scott P.
Orsini, Caitlin
Ortinski, Pavel
Ortiz, Abigail
O’Shea, K. Sue
Oskooilar, Nader
Osman, Douglas
Osorio, Ricardo
Otaduy, Maria
Otis, James
Ottis, Philipp
Ouchi, Yuya
Ouyang, John
Owen, David
Owens, Michael
Owens, W. Anthony
Owrutsky, Zoe
Oxenkrug, Gregory
Ozburn, Angela
Ozonoff, Sally
Pace, Thaddeus
Pachas, Gladys
Pack, Thomas
Paiardini, Mirko
Pai, Ya-Mei
Palesh, Oxana
Palmatier, Matthew
Palmer, Abraham
Palmer, James
Pan, Pedro
269
148
175
179
219, 238
77, 182
269
197
238
236
208
122, 189, 193,
271, 273
227
217
137
228
21, 207
226
234
227
185
262
208
183, 235, 275
237, 274
181
222
199
265
205
248
180
231
227
191, 192
270
169
214
215
205
278
148
259
198
188
175
233
184
135
112, 197
253
171
318
11/10/15 9:59 AM
Pandey, Subhash
Pandya, Chirayu
Pantazopoulos, Harry
Papakostas, George
Pappadopulos, Elizabeth
Paquette, Alison
Parade, Stephanie
Pardo, Jose
Parekh, Puja
Parikh, Vinay
Parise, Eric
Parisi, Maurizio
Pariyadath, Vani
Park, Jin-Young
Park, Joon Hyuk
Park, Minkyung
Park, Su Mi
Park, Sung Il
Parker, Clarissa
Parker, Emily
Parner, Erik
Parsey, Ramin
Parsons, Loren
Parvaz, Muhammad
Pasca, Anca
Pasca, Sergiu
Pasqui, Francesca
Passchier, Jan
Passos, Ives
Pasternak, Ofer
Pastorello, Bruno
Patel, Ashruta
Patel, Raihaan
Patel, Sachin
Patel, Veena
Patrick-Miller, Linda
Patterson, Beth
Patterson, Paula
Pauli, Paul
Paulus, Martin
Pearlson, Godfrey
Peckham, Andrew
Pedersen, Cort
Pedrosa, Erika
Pe’er, Itsik
Pemberton, Joy
Pena-Bravo, Jose
Peña, Catherine
Pena, Stephanie
Penetar, Dave
Peng, Kathy
Peng, Qian
Penn, David
277
177
271
174, 179
262
170
170
205, 260
241
183, 193
218
271
115
262
165
177
268
253
196, 197
226
249
174
279
236, 238, 275
262
136, 262
185
184
219, 257
234
248
270
186
132, 167
189, 232
171
248
218
166
121, 207, 251, 264
196, 230, 232
178
220
228
273
168
198
178, 195
21, 207
277
207
172
226
Penninx, Brenda
Penrod, Rachel
Penton-Voak, Ian
Penzes, Peter
Perera, Tarique
Perez-Rodriguez, Mercedes
Perkins, Diana
Perra, Valentina
Perriello, Christine
Perusini, Jennifer
Pessiglione, Mathias
Pestreich, Linda
Peter, Cyril J.
Peter, Diya
Peters, Amy
Peters, Bart
Peters, Matthew
Peterson, Bradley
Peterson, Michael
Peters-Strickland, Timothy
Petkova, Eva
Petrides, Georgios
Petryshen, Tracey
Pfau, Madeline
Pfleiderer, Bettina
Pham, Dung Vu Hanh
Pham, Thu Ha
Phan, K. Luan
Phenis, David
Phensy, Aarron
Philip, Noah
Philips, Jennifer
Phillips, Brett
Phillips, Karran
Phillips, Katharine
Phillips, Lawrence
Phillips, Mary
Phillips, Paul
Phu, Kenny
Picciotto, Marina
Pickup, Stephen
Pierce, Chris
Pierson, Matthew
Pikalov, Andrei
Pike, Victor
Pillai, Anilkumar
Pinborg, Lars
Pincus, Melanie
Pine, Daniel
Ping, Xingjie
253
279
209
97, 187
258
186, 215, 255,
256, 257, 264, 267
271, 272
235
168
173
224
193
228
177
178
230
224
260
37, 176, 188
193, 232, 265
210, 217
234, 255, 270
179, 190, 213
213
167
210
173
201, 246
235
230
166, 182, 221
183
180
201
168
224
2, 125, 161, 180,
218, 250, 261
2, 113, 274
206
179, 253
208
91, 195
174
172, 214, 218,
221, 252, 268
35, 36, 172, 182
177
265
278
207, 208, 209, 213
185
319
11/10/15 9:59 AM
Pini, Giorgio
Pinkham, Amy
Pinter, Christine
Pipitone, Jon
Piras, Giovanna
Pirpinias, Stephen
Pitcher, Meagan
Pittman, Brian
Pittman, Gabrielle
Pizzagalli, Diego
Planeta, Beata
Platenga, Margreet
Plitman, Eric
Plota, Jessica
Plott, Susan
Pocivavsek, Ana
Poelmans, Geert
Polizzotto, Nicola Riccardo
Pollock, Bruce
Pollock, Michael
Polosan, Mircea
Polter, Abigail
Pomara, Nunzio
Pommy, Jessica
Pomper, Martin
Pope, Harrison
Popiolek, Michael
Poptani, Harish
Porcu, Alessandra
Port, John
Porter, Warren
Posner, Jonathan
Posse, Patricio Riva
Postell, Elizabeth
Postolache, Teodor
Potenza, Marc
Pothula, Venu
Potkin, Steven
Potter, Alexandra
Potter, Guy
Potter, William
Pouget, Jennie
Powell, Susan
Powers, Abigail
Powers, Albert
Powers, Alex
Prabhakaran, Karthik
Prabhakaran, Ranjani
Prasad, Konasale
Prat, Monica
Pratt, Danielle
Preda, Adrian
Preskorn, Sheldon
210
226
253
210
280
195
254
276
241
134, 149
276
179
187, 269
184
169
223
213
270
186, 187, 226
196
274
240
217
261
224
168
261
208
240
169
185
173
258
233
272
196, 199
228
232, 265, 268
278
221
107
190
270
259
228
263
229
249
267, 271
264
234
232
216
Presti, Kendall
Preston-Campbell, Rebecca
Preston, Kenzie
Price, Amanda
Price, Lawrence
Prikulis, Ingrid
Prokai, Laszlo
Prosser, James
Prossin, Alan
Proudfit, Greg H.
Puhl, Matthew
Punzi, Giovanna
Purcell, Shaun
Purushothaman, Immanuel
Pyo, Chang-O
Qiu, Frank
Quadir, Sema
Quan, Meina
Quarmley, Megan
Quarto, Tiziana
Quidé, Yann
Quina, Lely
Quirk, Gregory
Rabin, Rachel
Rabinak, Christine
Rabiner, Eugenii
Rachkonda, Srinivas
Radewonuk, Jana
Radu, Luiza
Radulescu, Eugenia
Raetzman, Lori
Ragoza, Matthew
Rainnie, Donnald
Raja, Praveen
Rajadas, Jayakumar
Rajji, Tarek
Rajpurohit, Anindita
Rallapalli, Harikrishna
Ramaker, Marcia
Ramakrishnan, Charu
Ramakrishnan, Nithya
Ramchandani, Vijay
Ramdas, Shweta
Ramjas, Elizabeth
Ramos, Tonisha Kearney
Rampino, Antonio
Ramsey, Amy
Rana, Brinda
Ranganathan, Mohini
Rannals, Matthew
Rao, Julia
Rao, Naren
Rao, Rajini
192
236, 275
201
252
166, 217
231
222
185
263
227
231
212, 232
192
178, 195, 213
253
258
279
278
228, 229
212
227
213
102, 246
186, 229
246
184
232
171
181
232, 265
183
247
166
193
183
186, 226, 229, 235
249
185
215
195
270
154, 237, 242
173
215, 255, 256
196
174
272
190
241, 276
265
222
190, 267
162
320
11/10/15 9:59 AM
Rao, Uma
Rao, Vinod
Rapado-Castro, Marta
Rapanelli, Maximiliano
Rapaport, Mark
Rapoport, Judith
Rasenick, Mark
Rasgon, Natalie
Rashid, Mohammad
Rasmussen, Steven
Rasmusson, Grace
Rauch, Scott
Rauch, Sheila
Ravenstijn, Paulien
Ravichandran, Caitlyn
Ravindran, Arun
Ravula, Abhigyan
Rawson, Richard
Ray, Balmiki
Ray, Lara
Raychaudhuri, Soumya
Raznahan, Armin
Readhead, Ben
Redden, Sarah
Reddy, Ravinder
Reddy, Renuka
Reed, Michael
Reep, Jacob
Refojo, Damian
Regier, Paul
Reichel, Carmela
Reichenberg, Abraham
Reichert, Chelsea
Reider, Aubrey
Reid, Meredith
Reilly, James
Reiman, Eric M.
Reinhart, Veronica
Reisberg, Barry
Reissner, Kathryn
Remington, Anne
Remington, Gary
Ren, Qian
Renshaw, Chloe
Renshaw, Perry
Rentz, Dorene
Reppel, Jonathan
Resendez, Shanna
Ressler, Kerry
Ressler, Reed
Reti, Irving
2, 167
30, 281
250
103
131
249
131, 254
177
232
246
171
168, 179
166, 207
233
271
221
235
239
256
163, 237, 280
190
130
192
172
228
166
262
226
214
279
198, 239
118, 233, 249, 266
217
180
86, 194, 267
267
171
261
205
159, 199
165, 176
190, 266
173
219, 238
219, 238, 262
165
275
180
7, 81, 143, 166,
168, 175, 182,
206, 259, 264
183
170
Revheim, Nadine
Reyes-Madrigal, Francisco
Reyes, Teresa
Reynolds, Charles
Rezai, Ali
Ribases, Marta
Rice, Jake
Rice, Kenner
Rich, Katherine
Richard, Michelle
Richards, Erica
Richards, Jerry
Richardson, Charles M.
Richie, Christopher
Richter, Jan
Ricq, Emily
Riddle, Meghan
Ridener, Elysia
Ridout, Kathryn
Ridout, Samuel
Riedel, Michael
Riedner, Brady
Rief, Winfried
Riegel, Art
Riegger, Katelyn
Riggs, Lace
Rihel, Jason
Riley, Misha
Rimsky, Liza
Rincón-Cortés, Millie
Rinderspacher, Alison
Rios, Jose
Risbrough, Victoria
Rissling, Michelle
Rita, Baldi
Ritchie, James
Rivero-Covelo, Ignacio
Rizzo, Gaia
Rizzo, Lucas
Roach, Brian
Roalf, David
Roat-Shumway, Siena
Robbins, Trevor
Robert, Hubert
Roberts, J. Scott
Roberts, Laura
Robertson, Chelsea
Roberts, Rosalinda
Roberts-Wolfe, Douglas
Robinson, Delbert
Robison, Alfred
Roche, Daniel
Rodd, Zachary
226
269
208, 210
165
145
264
198
200
212
187
142, 177, 215
112
189
196
166
71, 185
221
221
170
217
236
188, 211
166
275
184
173, 276
223
71, 185
186
258
229
262
207, 247
184
167
238
261
270
277
44, 188
211, 228
177
145, 274
240
171
137
195, 239
190, 234
241
226, 230, 234, 270
216
237, 280
264, 277
321
11/10/15 9:59 AM
Rodriguez, Carolyn
Rodriguez, Cristin
Rodriguez-Romaguera, Jose
Rodriguiz, Ramona M.
Roeder, Kathryn
Roe, Katherine
Roelke, Erin
Roffman, Joshua
Rogers, Geraint
Rogers, John
Rogowska, Jadwiga
Roh, Youkyung Sophie
Rohatagi, Shashank
Rohde, Luis
Rohn, Matthew C.H.
Rohrig, Stephanie
Rojas, Jennifer A.
Rollins, Brandi
Roman, Carolyn
Roman, Kaitlyn
Ron, Dorit
Rooij, Sanne van
Rook, Jerri
Rooney, William
Roop, Gregory N.
Ropchan, Jim
Roper, Randall
Rosa-Neto, Pedro
Roseboom, Patrick H.
Rose, Frank
Rosenblum, Leonard
Rosen, Bruce
Rosenkranz, J. A.
Rosenthal, Elizabeth
Ross, David
Ross, Rachel
Ross, Randal
Ross, Stephen
Ross, Thomas
Rossi, Amie
Rosso, Isabelle
Rostrup, Egill
Rothbaum, Barbara
Roth, Bryan
Rothman, Karen
Rothschild, Anthony
Rothwell, Patrick
Rotrosen, John
Rotzinger, Susan
Roussos, Panos
Rowland, Laura
Roy, Alicia
Roy, Bhaskar
124, 167
270
246
268
249
249
222
231, 256
214
253
218
273
193
171
281
226
199
256
222
191
110
264
245, 268
108
245
197
263
236
246
257
178
231
278
228
223
208
144, 168
236
241
235
179
234, 265
102, 207
188
193
175
62, 79, 80, 184
236
256
99, 192, 267
223, 272
167
179
Royster, Erica
Rubia, Katya
Rubin, Eric
Rubinow, David
Rück, Christian
Rudebeck, Peter
Ruderfer, Douglas
Ruiz, Rebecca
Ruiz-Sancho, Ana
Ruland, Tillmann
Rullo, Santo
Ruparel, Kosha
Rupert, Petra
Rusak, Benjamin
Russell, Theron
Russo, Manuela
Russo, Scott
Ryan, Kyle P.
Ryan, Megan
Ryan, Neal
Sabbagh, Jonathan
Sabb, Fred
Saber, Yasir
Sabino, Valentina
Sacchetti, Benedetto
Sacher, Julia
Sackeim, Harold A.
Sagalyn, Erica
Saha, Debjani
Sahay, Amar
Sahlem, Gregory
Saillard, Jelena
Saini, Aashna
Saito, Atsushi
Sakharkar, Amul
Salahpour, Ali
Salah-Uddin, Hasib
Salibi, Nouha
Salinas, Armando
Salmeron, Betty Jo
Salton, Stephen
Saltz, Samantha
Salum, Giovanni
Salvadore, Giacomo
Salzman, Phyllis
Sammel, Mary D.
Sampson, Maureen
Sampson, Shirlene
Samuels, Benjamin A.
Sanacora, Gerard
Sánchez, Cristina
Sanchez-Gutierrez, Teresa
224
198
198
2, 114, 180, 181,
214
173
170
192
187
250
167
271
200, 211, 229
228, 229
181
187
215, 255, 256, 257
2, 213, 276
193
200
247
255
239
200
212, 253
266
19, 27, 28, 29, 260
216
196
233, 274
7, 10, 11, 109
216
267, 268
249
265
277
272
251
267
197
198, 241
68, 194
213
171
177, 181, 253
265
177
167
169
254
174, 177
256
250
322
11/10/15 9:59 AM
Sanchez, Mar
Sanders, Stephan
Sandiego, Christine
Sanmiguel, Claudia
Santiago-Medero, Carlos
Santoro, Giovanni C.
Sanwald-Ducray, Patricia
Sapin, Christophe
Sapio, Matthew
Sari, Youssef
Sarpal, Deepak
Sarter, Martin
Sartorius, Alexander
Satterthwaite, Theodore
Saunders, Benjamin
Saunders, Erika
Saunders, Madeleine
Sauve, William
Savell, Katherine
Savitt, Adam
Savitz, Adam
Savitz, Jonathan
Sawa, Akira
Sayegh, Philip
Scaramello, Nayla
Scarf, Bruce
Scattoni, Maria Luisa
Schaare, Lina
Schachar, Russell
Schacht, Joseph
Schadt, Eric E.
Schaefer, Carola
Schappi, Jeffrey
Schattauer, Selena
Schatzberg, Alan
Scheele, Dirk
Schendel, Diana
Schifano, Fabrizio
Schiller, Crystal
Schiller, Daniela
Schilling, Shirin Khan
Schlüter, Oliver
Schmahl, Christian
Schmauss, Claudia
Schmerberg, Claire M.
Schmid, Bianca
Schmid, Cullen
Schmidt, Heath
Schmidt, Mathias V.
Schmidt, Matthew
Schmidt, Peter
Schmidt, Simon Nitschky
Schmitt, Lauren
278
130
197
263
253
201
217
232, 265
213, 264
275
226, 255
183
156
178, 211
196
180
74, 168
225
274
229
233, 268
216
126, 184, 197
224
226
178
148
27, 260
210
275
225
264
254
255
217
184
249
240
214
226
177
178
150, 264
190
268
214
201
91, 195, 199
214
216
181, 214
232
211
Schmitz, Gavin
Schmitz, Joy
Schnebelen, Wendy
Schneider, Frank
Schneider, Isabella
Schneider, Julie
Schoch, Hannah
Schoene, Manja
Schoenfeld, David
Schofield, Peter
Schonfeld, Daniel
Schooler, Nina
Schoonover, Kirsten
Schork, Nicholas
Schotte, Alain
Schroeder, Frederick
Schuebel, Kornel
Schulze, Thomas
Schumacher, Jackson
Schuster, Randi
Schwab, Markus
Schwandt, Melanie
Schwarcz, Robert
Schwartz, Barbara
Schwartz, Carl
Schwartz, Danielle
Schwartz, Jaclyn
Schwartz, Thue
Schwarz, Emanuel
Schweiger, Julie
Schweinsburg, Brian
Scofield, Michael
Scott, Elizabeth
Scott, J. Cobb
Scott, Liam
Scott, Stuart
Scott, Talia
Scranton, Victoria
Scribner, Jennifer
Seabrook, Guy
Seandel, Marco
Searle, Graham
Seasholtz, Audrey
Sedlak, Thomas
See, Ronald
Segall, Judith
Segal, Zindel
Sehatpour, Pejman
Seidman, Larry
Seifer, Ronald
Selby, Peter
Self, David
Selvaraj, Sudhakar
253
241
170
126
126
251
208, 210
218
198
46, 186
224
191, 234
190
172, 212
233
71, 185, 230
181
2, 126
235
242, 275
139
154, 201, 237, 248
133, 223
191
248
276
260
190
264
250
167
236, 240
258
167
191
192
208
262
262
216
189
184
274
265
239
232
221
234
169, 227, 271, 272
170
237
198, 278
270
323
11/10/15 9:59 AM
Sen, Srijan
Senço, Natasha
Senturk, Damla
Seo, Dongju
Sepulveda-Orengo, Marian T.
Sequeira, Adolfo
Serra, Gian Pietro
Sershen, Henry
Setlow, Barry
Seung-Kwon, Sean
Sevy, Serge
Shaffer, Scott
Shah, Romi
Shah, Tanzeel
Shah, Umang
Shaikh, Jahanzeb
Shalvoy, Alexandra
Shanahan, Megan
Shansky, Rebecca
Shapiro, Alice
Shapiro, Lauren
Share, D. Barrett
Sharif-Askary, Banafsheh
Sharifi, Mohammed
Sharif, Kayvon
Sharma, Anup
Sharma, Vinod
Shavitt, Roseli
Shay, Lena
Shea, Stephen
Shekhar, Anantha
Sheline, Yvette
Shelton, Richard
Shen, Erica Y.
Shen, Jun
Shen, Li
Shen, Pei-Hong
Shen, Ying
Shenton, Martha
Sher, Emanuele
Sher, Leo
Sherif, Mohamed
Shi, Qiaoyun
Shi, Zhenhao
Shields, Jerry
Shihabuddin, Lina
Shih, Pei-an Betty
Shilling, Paul
Shilling-Scrivo, Kelson
Shin, Gunchul
Shin, J. Hoon
Shin, Joo Heon
Shin, Paul
165, 205, 206, 245
248
167
199
199
211, 256
235
192
183, 235, 245, 275
269
270
175
205
205
205
192
230
255, 256, 257
114, 206
225
219
267
209
192
196
257
250
247, 248
211
206
247
178
174, 179, 217, 220
228
227
178, 213
247
197
169, 227
185
186
241
272
200
193
266
212
232
180
253
189
212, 232, 249
225
Shinn, Ann K.
Shinohara, Russell
Shinohara, Taki
Shirayama, Yukihiko
Shiroma, Paulo
Shoblock, James
Shohamy, Daphna
Shokri-Kojori, Ehsan
Short, E. Baron
Short, Jenna
Shou, Haochang
Shrestha, Stal
Shriram, Jahnavi
Shulman, Melanie
Shungu, Dikoma
Shuto, Takahide
Sial, Omar
Sibille, Etienne
Sibley, David
Siciliano, Cody
Siddiqui, Ishraq
Sidor, Michelle
Siever, Larry
Siffert, Joao
Sigel, Ben
Silipo, Gail
Silverstein, Noah
Silvestri, Guido
Simmler, Linda D.
Simmons, Alan
Simmons, W. Kyle
Simon, Amanda
Simon, Naomi
Simon, Nicholas
Simonnet, Clémence
Simpson, Helen
Simpson, Kailey
Simpson, William
Sindhunata, Ivan
Singer, Harvey
Singh, Jaskaran
Singh, Manpreet
Singh, Pankaj
Singh, Prachi
Singh-Taylor, Akanksha
Singley, Erick
Sinha, Rajita
Sipilä, Tessa
Sippas, Shabnam
Sirohi, Sunil
Sisk, Cheryl
Siu, Cynthia
Sklar, Pamela
273
211
178
173
260
214, 218
24, 269
279
216
188
178
172
231
205
260
197
218
185
189
20, 39, 197, 201
266
241
186, 264, 267
185, 225
168
226
231
175
237
251
222
211
246
241
64, 182
124, 167
235, 245
248
269
225, 250
181, 218, 220, 253
125, 219
266
172
252
237
98, 196, 199
222
215
198, 251
138
189
192
324
11/10/15 9:59 AM
Skosnik, Patrick
Sledge, George
Slemmon, Randy
Slifstein, Mark
Sloan, Steven
Slutske, Wendy
Small, Brent J.
Small, Keri
Smart, Kelly
Smethells, Jack
Smit, August
Smith, Aaron
Smith, Alexander
Smith, Alicia
Smith, Edward
Smith, Eric
Smith, Jaclyn
Smith, Jane Lea
Smith, Jason
Smith, Jodi
Smith, Joshua
Smith, Kelsey
Smith, Laura
Smith, Lia
Smith, Nathaniel
Smith, Paul
Smith, Robert
Smith, Stephen
Smoller, Jordan
Smucny, Jason
Snellenberg, Jared Van
Snipes, Jon
Soares, Jair
Sobczak, Gabe
Sodhi, Monsheel
Sohal, Vikaas
Sokoloff, Greta
Solecki, Wojciech
Solomon, Matia
Soltys, David
Somandepalli, Krishna
Sommer, Iris
Song, David
Song, Hongjun
Song, Huijing
Song, Won-min
Sonnenfeld, Danae
Sonnenschein, Susan
Sora, Ichiro
Soreni, Noam
Sorg, Barbara
241, 276
184
218, 225
24, 41, 66, 202,
268, 269
262
172
208
253
236
279
231
223
120, 240
189, 206, 264
24, 269
178
71, 185
193
235
185
196
169
278, 279
199
212
213
192, 205
262
7
269
19, 24, 25, 26, 41,
268, 269
216
181, 219, 257
274
230
158
197
253
258
252
210
265
247
151
260, 261
178
167
188
191
210
120
Sosinsky, Alexandra
Sotogaku, Naoki
Sottile, Melanie
Souaiaia, Tade
Sourander, Andre
Sousa, Vasco
Southall, Noel
Southwick, Steven
Spagnolo, Primavera
Spann, Marisa
Spechler, Phil
Spence, Jeffrey
Spencer, Kevin
Spencer, Robert
Spencer, Sade
Spiegel, David
Spivak, Charles
Sponheim, Scott
Sprooten, Emma
Sripada, Chandra
Sripada, Rebecca
Srivastava, Amand
Stafford, Jacob
Stair, Jaqueline
Stange, Jonathan
Stangl, Bethany
Stankoski, Dean
Stanley, Jeffrey
Stansbury, Melissa
Stanwood, Gregg
State, Matthew
Staveland, Brooke
Steckler, Thomas
Stefan, Mihaela
Stefano, Alexis
Steffens, David
Stein, Dan
Stein, Elliot
Stein, Jason
Stein, Murray
Steiner, Meir
Steinman, Shari
Stennett, Bethany
Stephen, Julia
Stephens, Clay
Stern, Emily
Stertz, Laura
Stevens, Hanna
Stevens, Jennifer
Stevens, Michael
Stevenson, James
Stewart, Adele
216
197
249
246
171
175
189
167
145
171
278
198
227
183, 208
241, 276
184
196
232
232, 269
206
166, 207
232
208
240
178
242
277
271
220
101, 189
223
219
104
172
206
221
206
163, 198, 236,
241, 278
178
207
221
167
196
232
264
250
231
129, 169
166, 206, 264
196
267
209
325
11/10/15 9:59 AM
Stewart, Donna
Stewart, Shona
Steyn, Stefanus
Stiffler, Richelle
Stockburger, Carola
Stoddard, Joel
Stodola, Diane
Stoeckel, Luke
Stoffel-Wagner, Birgit
Stoops, Anastasia
Storch, Eric A.
Stout, Robert
Stowe, Zachary
Strafella, Antonio
Strakowski, Stephen
Strawn, Jeffrey
Strecker, Robert
Streffer, Johannes
Streicher, Caroline
Streicher, Joshua
Stringfield, Sierra
Stroiney, Amanda
Stuber, Garret
Stutz, Sonja
Su, Katy
Su, Tung-Ping
Subotnik, Kenneth L.
Suchting, Robert
Sudheimer, Keith
Suh, Jesse
Sullivan, Katherine A.
Sullivan, Patrick
Sullivan, Regina
Summergrad, Paul
Sun, Gordon
Sun, Hong
Sun, Hui
Sun, Wenchao
Sun, Yinming
Sun, Yu
Sunderajan, Prabha
Suner, Talia
Sung, Young Hoon
Suomi, Stephen
Suppes, Trisha
Surcel, Heljä-Marja
Suridjan, Ivonne
Surti, Toral
Sutherland, Matthew
Sutterland, Arjen
Sutton, Steve
Suzuki, Takefumi
Svarer, Claus
221
223
261
180, 218
245
209
169
224
184
234
208
168
169, 238, 254
190
176, 220
176
227
225
252
258
201
209
160, 180
252
21, 207
233
233
241
217
279
238
192
248
205
79, 184
187
237
183
259
181
174
255
219, 238
248
172, 218
171
190
241, 276
236, 241
266
48, 176
186, 187, 226
265
Svenningsson, Per
Svenson, Abby
Svensson, Torgny
Swails, Lisette W.
Swain, James
Swalve, Natashia
Swanson, Chelsea
Sweatt, David
Sweeney, John
Sweet, Lawrence
Sweet, Robert
Swerdlow, Neal
Swift, Robert
Sylvia, Louisa
Szalai, Erzsébet
Szatmári, Balázs
Szatmari, Peter
Szczepanik, Joanna
Szeszko, Philip
Szumlinski, Karen
Takahashi, Joseph
Takahasi, Yuko
Takamiya, Yoshihiro
Takamura, Masahiro
Takayanagi, Yoichiro
Talero, Jessica
Talledo, Jo
Tamminga, Carol
Tan, Hao Yang
Tan, Zhibing
Tanaka, Serena
Tanaka, Teppei
Tanda, Gianluigi
Tandon, Kopal
Tang, Cheuk
Tang, Diane
Tang, Wei
Taniguchi, Makoto
Taniguchi, Yu
Tanner, Alexandra
Tanskanen, Antti
Tao, Ran
Tapert, Susan
Tapocik, Jenica
Tarasenko, Melissa
Tarazi, F.I.
Tarazi, Frank
Tariot, Pierre
Taterra, Dominik
Tavares, Hermano
Tavares, Rita
175
175
191
189
170
279
248
274
211, 230, 267
166
97, 187, 193, 273
190, 226
101
178
88, 194
88, 194
210
179
165, 205, 226,
230, 234, 245
117, 165, 202,
205, 245, 279
278
187
227
215
126
273
190, 226
230
233, 274
266
183
192
281
173
219
253
178
278, 279
265
231
188
231
147, 168
237
190
171
187
171
196
261
226
326
11/10/15 9:59 AM
Taylor, Jane
Taylor, Joseph
Taylor, Kirsten
Taylor, Margot
Taylor, Matthew
Taylor, Stephan
Taylor, Walter
Taylor, Warren
Teague, Kent
Teicher, Martin
Tempia, Filippo
Teroganova, Nina
Terrillion, Chantelle
Terry, Alvin
Teslovich, Theresa
Thames, April
Thankachan, Stephen
Thanseem, Ismail
Thase, Michael
Theyel, Brian
Thiel, Christiane
Thoma, Robert
Thomas, Jason
Thomas, Mary
Thompson, Allison
Thompson, Britta
Thompson, David
Thompson, Summer
Thomsen, Christian
Thomsen, Morgane
Thuras, Paul
Thurnauer, Halle
Tian, Chao
Tian, Jing
Tian, Ju
Tian, Yuan
Tierney, Patrick
Tiger, Mikael
Tiihonen, Jari
Tillisch, Kirsten
Tiwari, Arun
Tocco, Michael
Todd, Kevin
Todd, Travis
Tohen, Mauricio
Toki, Shigeru
Tomasi, Dardo
Tonelli, Leonardo
Tong, My-Linh
Tonin, Paula
Tononi, Giulio
Torniainen, Minna
Torossian, Carol
212
258
267
210
257
193, 246
196
221
216
262
266
227
205
177
191
224
227
170
220, 257
225
165
261
175
196
207
250
179
215
253
279
260
241, 276
216
230
30, 281
262
235
173
188
263
178, 256
268
247
229
230, 270
215
197, 276, 279
205
199
254
188, 211
188
205
Torregrossa, Mary
Tottenham, Nim
Toufexis, Donna
Towle, Vernon
Tractenberg, Saulo
Tran, Justine
Tran, Steve
Trantham-Davidson, Heather
Travis, Michael
Treado, Patrick
Treadway, Michael
Tregellas, Jason
Trejo, Marcia
Treyer, Valerie
Triana-Baltzer, Gallen
Tronson, Natalie
Trontti, Kalevi
Tropea, Daniela
Trossbach, Svenja
Tsai, Guochuan
Tsai, Joyce
Tseng, George
Tseng, Wan-Ling
Tseng, Wen-Yih Isaac
Tso, Ivy
Tsuang, Ming
Tsuda, Ayumi
Tsujii, Masatsugu
Tully, Laura M.
Tu, Pei-Chi
Turecki, Gustavo
Turetsky, Bruce
Turiak, Lilla
Turkheimer, Federico
Turna, Jasmine
Turnbull, Lacie
Turner, Cortney
Turner, Eric
Turner, Jessica
Turner, Jill
Turner, Katherine
Twamley, Elizabeth
Tweardy, Samuel
Tye, Kay
Tyndale, Rachel
Tyrer, Andrea
Tyrka, Audrey
Uchida, Hiroyuki
Uchida, Naoshige
Uddin, Monica
Uhde, Thomas
Uhl, George R.
196
7, 16, 17
222
225
277
232
86, 194
169
223
223
123
262, 269
167
32, 266
218, 225
183, 259
222
210
231
272
172, 214, 218, 221
185, 233
213
210
193
169, 272
240
170
273
233
177, 213, 276
228, 229
271
270
248
259
173
213
189, 232, 261, 269
237
223
226
212
64, 117, 160, 165,
182, 205, 245
237
253
166, 170, 217
186, 187, 226
30, 281
206
167
191
327
11/10/15 9:59 AM
Umbricht, Daniel
217, 267
Umhau, John
237
Umpierrez, Guillermo
259
Underwood, Mark
254
Ung, Randall
180
Upton, Brian
235
Urban, Nina
281
Urs, Nikhil
158, 188
Ursini, Gianluca
212, 232
Väänänen, Juho
222
Vacco, Michael
200
Vadhan, Nehal
66, 202
Vadodkar, Aditi
211
Vaidya, Chandan
191
Vaidya, Jatin
232
Valente, Michael
269
Valentini, Valentina
235, 280
Valentino, Rita
2, 53, 57, 58, 169
Valenza, Marta
179
Valera, Eve
249
Valuskova, Paulina
183
Valvassori, Samira da Silva
254
Van Ameringen, Michael
248
Van Buskirk, Gerard
246
Vance, Monika
262
van de Giessen, Elsmarieke
24, 66, 202, 269
Vandekar, Simon
211
van der Ark, Peter
218
van der Veen, Jan Willem
227
Vanderzee, Karin
168
Van Dijk, Koene
256
van Kesteren, Charissa
265
Van Nest, Duncan
199
Vanover, Kimberly
267, 268
van Rhee, Frits
181
Varambally, Shivaram
267
Varela, Roger
254
Varigonda, Anjali
257
Varrone, Andrea
173
Vasilesvo, Vitaly
211
Vaughn, Bradley
233
Vawter, Marquis
256
Vazey, Elena
260
Veenstra-VanderWeele, Jeremy 2, 103, 237
Veigne, Sandra
205
Veith, Jennifer L.
201
Velazquez-Sanchez, Clara
212, 253
Veldic, Marin
214
Velthorst, Eva
118, 266
Venkataraman, Archana
221
Venkatasubramanian, Ganesan 267
Ventura, Joseph
233
Vermeulen, Jessica
181
Veronese, Mattia
Versace, Amelia
Verstegen, Anne
Vervliet, Bram
Vichaya, Elisabeth
Vickers, S.
Victor, Navarro
Viguera, Adele
Vilchez, Crystal
Villers-Sidani, Etienne de
Villringer, Arno
Vinar, Oldrich
Vincent, Jessica
Viner, Jane
Vinogradov, Sophia
Viscanti, Giovanna
Vitaliano, Franco
Vitaliano, Gordana
Viviano, Joseph
Vogl, Annette M.
Vohs, Jenifer
Voineskos, Aristotle
Voineskos, Daphne
Volgman, Caroline
Volk, David
Volkow, Nora
Vollbrecht, Peter
Volmar, Claude-Henry
Voon, Valerie
Voort, Jennifer Vande
Vora, Anvi
Vora, Avani
Voronin, Konstantin
Voyvodic, James
Vranesic, Melin
Vranjkovic, Oliver
Vsevolozhskaya, Olga
Vyas, Gopal R.
Wahlestedt, Claes
Wajs, Ewa
Walker, Brendan
Walker, Christopher
Walker, David
Walker, Deena
Walker, Elaine
Walker, Robrina
Wall, Christopher
Wall, Melanie
Wall, Shannon
Wallace, Tanya
35, 36, 182, 270
125, 180, 250
208
143, 247
123
171
208
216
201
122
27, 260
224
241
248
122, 190
212
262
262
209, 210
214
272
165, 205, 209,
210, 245, 251, 266
259
199
191
18, 66, 98, 116,
197, 202, 230,
276, 279
246
251
154, 274
209
267
248
275
232
224
274
238
189
99, 110, 251
218
198, 280
270
249
178, 195
271, 272
198
169
212, 277
235
267, 274
328
11/10/15 9:59 AM
Walsh-Messinger, Julie
Walsh, Trisha
Walss-Bass, Consuelo
Waltz, James
Wang, An-Li
Wang, Changning
Wang, Chuang
Wang, Cuidong
Wang, Dai
Wang, Danhong
Wang, Gene-Jack
Wang, Hongsheng
Wang, Jing
Wang, Junshi
Wang, Lei
Wang, Lien
Wang, Minghui
Wang, Rong
Wang, Shuai
Wang, Yuchuan
Wang, Ze
Wang, Zhishun
Wang, Zhiwei
Waplinger, Spencer
Wardle, Margaret
Waterhouse, Barry
Waters, Andrew
Watkins, Briana M.
Watson, Stanley
Watts, Val
Weafer, Jessica
Webb, Christian
Weber, Dylan
Weber, Wade
Weddington, Javier
Wegener, Gregers
Wegener, Meredyth
Wehring, Heidi J.
Weickert, Cynthia Shannon
Weickert, Thomas
Weide-Fischer, Christina
Weiller, Emmanuelle
Weinberger, Daniel
Weingart, Michal
Weinstein, Jodi
Weisenbach, Sara
Weiser, Mark
Weiss, Blair
Weiss, Catherine
Weiss, Elizabeth
189
171
231
187
200
71, 185
211
280
181
222
197, 276, 279
266
237
178
232
231
178
201
212
224
279
41, 172, 268, 281
185, 231
241
241
208
276
270
173, 217
189
201
179
251
220
261
175
241
189
46, 139, 186
20, 46, 47, 186
175
177, 180, 191, 192
151, 212, 223,
227, 232, 233,
234, 245, 249,
265, 267, 274
267, 268
62, 66, 67, 202
222
118, 233
165
177, 191, 192
207
Weiss, Susan
Weissman, Myrna
Weissman, Noah
Welge, Jeffrey
Welsh, Robert
Welty, Natalie
Wemmie, John
Wenderski, Wendy
Werner, Sandra
West, Jef
Westermeyer, Joseph
Westlund, Melinda
Wetherill, Reagan
Wetsel, William C.
Wheaton, Michael
Wheeler, Anne
Whelan, Robert
Whitaker, Annie
White, Amanda
White, Cherise
White, David
White, Lauren
White, Marney
White, Michael
White, Stormi
Whitfield-Gabrieli, Susan
Wickham, Robert
Wicks, Brittany
Widge, Alik
Wieck, Andrea
Wierenga, Christina
Wiers, Corinde E.
Wiersielis, Kimberly
Wiggins, Jillian
Wijtenburg, Andrea
Wikramanayake, Maheshi
Wilcox, Charles
Wilcox, Claire
Wilcox, Marsha
Wilcox, Troy
Wildes, Craig
Wildman, Derek
Wiley, Katherine
Wilhelm, Sabine
Wilhelmsen, Kirk
Williams, Aislinn
Williams, Angela
Williams, Janet
Williams, Leanne M.
Williams, Nia
Williams, Steve
Williams III, Wilbur
Willoughby, Adrian
126
173
255
176
222, 246
214
159
263
263
223
199
210
279
268
167
209
121
208
183
250
86, 194
213
196
223
211
165, 176, 180
253
246
178
210, 277
171, 212, 251
279
246
213
223, 272
166
199
113
268
196
64, 182
206
44, 188
168, 208
172
222
280
265
219
240
187
241
274
329
11/10/15 9:59 AM
Wills, Zachary
Willuhn, Ingo
Wilson, Alan
Wilson, Joseph
Wilson, Mark
Wilson-Poe, Adrianne
Wilson, Stephen
Wimmer, Mathieu
Winer, Jeremy
Wingo, Aliza
Winner, Joel
Winstanley, Catharine
Wissman, Anne Marie
Witkin, Jeffrey
Wittenberg, Gayle
Witten, Ilana
Wodrich, Andrew
Wohleb, Eric
Wojcik, Joanne
Wolf, Daniel
Wolfe, David
Wolfe, Maura
Wolf, Marina
Wommack, Evanthia
Wong, Albert
Wong, Christopher
Wong, Dean
Wong, Edmund
Wong, Jenny
Wong, Ma-Li
Wons, Kevin S.
Wood, Beth McCarty
Wood, Joel
Wood, Susan
Woodberry, Kristen
Woods, James
Woods, Scott
Woodside, Blake
Woodward, John
Woolley, Catherine
Woolwine, Bobbi
Worhunsky, Patrick
Wotjak, Carsten T.
Wray, Nathan
Wright, Carrie
Wright, Robert
Wright, Susan
Wrocklage, Kristen
Wu, Helen
Wu, Jie
Wu, Jiejun
Wu, Johnathan
Wu, Minjie
187
274
190, 253
259
278
198
223
63, 91, 92, 93, 195
276
206
256
200
198
185
181, 253
160
251
174
227
211, 229
181
222
2, 159, 278
220
266
276
225, 268
219
253
213, 214
223
171
228
169
227
189
271, 272
212
199
53, 56
219, 220, 259
196
214
254
249
266
272
167
262
278
48, 176
183
185
Wu, Mon-Ju
Wu, Qiang
Wulsin, Aynara
Wurfel, Brent
Wurst, Wolfgang
Wyatt, Naomi
Wylie, Korey
Wynn, Jonathan K.
Xantus, Arunditi
Xi, Liwen
Xia, Li
Xiao, Ena
Xiong, Wen-Cheng
Xu, Haiyan
Xu, Jane
Xu, Jinfeng
Xu, Jishu
Xu, Junqian
Xu, Ke
Xu, Rong
Xu, Xiaoming
Xu, Xiaoyan
Xu, Ying
Xu, Ziye
Yamada, Hiroshi
Yamamoto, Hideko
Yamamoto, Tetsuya
Yamawaki, Shigeto
Yan, Hao
Yang, Chun
Yang, Guang
Yang, Hongyan
Yang, Hongyu
Yang, Jun
Yang, Qing
Yang, Shaolin
Yang, Xiao
Yang, Yihong
Yangdhar, Nyima
Yankowitz, Lisa
Yao, Beier
Yao, Wei
Yao, Xiang
Yao, Yin
Yardley, Megan
Yates, Nathan
Yates, Stefani
Yates, William
Yau, Yvonne
Yazdani, Neema
Ye, Allen
Ye, Weiguo
Yehuda, Rachel
181, 219
211
258
216
214
214
262, 269
227
213
218
274
245, 265
266
233
252
205
251
250
225
35, 36, 182
229
66, 202
178, 211
187
187
195
215
215
274
173
274
167
165
212
167
185, 222
172
198
240
249
193
173
48, 176, 253
255, 259
237
273
83, 194
216
200
197
215, 222
268
206, 240
330
11/10/15 9:59 AM
Yepes, Maelys
Yieh, Lynn
Yin, Dongmin
Yingling, Michael
Yip, Sarah
Yocca, Frank
Yonan, Charles
Yoo, Ji Hoon
Yoon, Gihyun
Yorgason, Jordan
You, Xiaozhen
Young, Chelsea
Young, Damon
Young, Elizabeth
Young, Jared
Young, Jonathan A.
Young, Kimberly
Young, Matthew
Young, Paulina
Youngstrom, Eric
Youssef, Mary
Yu, Hong
Yu, Jin
Yuan, Qiaoping
Yue, Weihua
Yung, Matthew
Yun, Sujin
Yurgelun-Todd, Deborah
Zachariou, Venetia
Zack, Sanno
Zai, Clement
Zaia, Joseph
Zaiko, Yevgeniya
Zakharenko, Stanislav
Zakzanis, Konstantine
Zallen, Doris
Zambotti, Massimiliano de
Zannikos, Peter
Zanos, Panos
Zanotti-Fregonara, Paolo
Zaparte, Aline
Zarate, Carlos
Zavorotnyy, Maxim
Zawadzki, John
Zaylaa, Amira
Zeitzer, Jamie
Zejnelovik, Faketa
Zell, Vivien
Zelli, Danielle
Zemelman, Boris
Zepf, Florian Daniel
Zerbe, Gary
264
48, 176, 253
266
250
196
107
225
183
199
39, 195, 201
191
170
235
173
255, 269
184
279
167
240
183
192
185
230, 273
181, 247, 264, 267
274
272
48, 176
218
152
207
178
271
207
136
266
171
274
218
205, 222
35, 36, 177, 182
210
2, 19, 20, 177,
179, 206, 215, 255
167
266
182, 258
184
169
183
257
208
215, 256
168
Zetterberg, Henrik
Zhan, Liang
Zhang, Aifeng
Zhang, Bin
Zhang, Bing
Zhang, Dai
Zhang, Hanting
Zhang, Hongxing
Zhang, Huaibo
Zhang, Hui
Zhang, Jianping
Zhang, Ji-Chun
Zhang, Lei
Zhang, Peter
Zhang, Sheng
Zhang, Song
Zhang, Tianhao
Zhang, Xiao
Zhang, Yanan
Zhao, Dejian
Zhao, Yihong
Zheng, Deyou
Zheng, Huiyong
Zheng, Jun-Qi
Zhi, Yun
Zhong, Wei
Zhou, Luyi
Zhou, Xianjin
Zhou, Yun
Zhou, Zhifeng
Ziegler, Christiane
Ziemer, David
Zilberman, Monica
Zilverstand, Anna
Zimmerman, Jared
Zitnik, Gerard
Zlebnik, Natalie
Zoghbi, Sami
Zoltick, Brad
Zomorrodi, Reza
Zorick, Todd
Zorowitz, Richard
Zorowitz, Samuel
Zsido, Rachel
Zubieta, Jon-Kar
Zukin, Stephen
Zunta-Soares, Giovana
Zuo, Yi
Zwanzger, Peter
Zwart, Ruud
Zwerling, Jordana
217, 225
222
222
178, 206, 225
237
274
178, 211
62, 68, 69, 70,
194, 256
277
241
230, 270
173
261
177
239
68, 194
211
274
277
228
210
228
259
280
223
175
237
270
225, 268
267
166
224
261
236, 275
256, 257
169
279
35, 36, 172, 182
245
229
235
225
178, 256
260, 261
115, 222
187
181, 219, 257
97
167
185
167
331
11/10/15 9:59 AM
Notes
332
11/10/15 9:59 AM

54th Annual Meeting - Parthenon Management Group

Transcription

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