Thierry Hertoghe - Terzo Congresso ImeB

Reverse
Aging Hair & Face
with
Hormones, Nutrients
& Herbs
Thierry Hertoghe
Healthy
(young adult)
Increasingly
unhealthier
with advancing age
=
New,
wellkept
house
Age 24, untreated
=
Age 64,
untreated
House not well cared of,
not repaired
=
Untreated
very old person
Ruin
How can
we
partially
or even
near
totally
reverse
the aging?
Ideally
=
Age 64, untreated
=
Age 68 =>
Outlook of a treated age 24?
Aim of Medicine: Make the patient as healthy as possible
Aim of Reversing Aging Medicine: Make the patient as young
as possible to be sure (s)he is at his (her) healthiest
Less healthy
Age 55
Healthier
Age 52
Age 58
Healthiest
Age 56
but looks as
a 40-year old
(15 years younger)
Age 60
60
but looks as
a 30-year old
(25 years younger)
Aging
Hair
Diffuse Hair Loss
Improved by
Thyroid
IGF-1-GH
Iron, Zinc, silicone
Diffuse
hair Vit. A, B5 (pantothenate),
B7 (biotin)
loss
Tyrosine, iodine
Cysteine, methionine,
cystine,
Diffuse Hair Loss
Improved by
Diffuse hair
loss
Kelp (→ Thyroid)
Other seaweeds
Kelp
For Thyroid Hormones,
Kelp, Dulse, & other
seaweeds
Kelp
Kelp: Doses
+/-250 µg iodine in 150 mg tablet
Product
Kelp
When tot take?
Wakeup
(2nd dose
before
supper)
Duration
Dose
Every day
for 1-12
months
per year
30 to 450
mg /day
(1 x 150
mg/day)
 Caution: at high doses, the iodine may suppress T4
secretion out of the thyroid & consequently induce
hypothyroidism
Upper Scalp Hair loss
Improved by
Male pattern Testosterone + finasteride
hair loss
Estrogen: 17-alpha-E2
Reduce red meat intake
(↑ DHT)
Improved by
Female
pattern
hair loss
Estrogen
Testosterone + finasteride
Upper Scalp Hair loss
Improved by
Male pattern Chrysin
hair loss
Saw Palmetto
Female
pattern
hair loss
Improved by
Black cohosh, red
clover, soy bean,
yarrow, angelica (→
estrogens)
Saw Palmetto
Herb extracts to reduce the conversion of
testosterone to DHT, dihydrotestosterone
Chrysin
Saw Palmetto
500 mg
80 mg
S/ 3x 1 to 2 capsules/day: at wake-up,
lunch & before bedtime
Chrysin
Chrysin = chemical name for a type of isoflavone
molecule that has been demonstrated to be a
potent aromatization blocker.
=> minimizes the conversion of testosterone to
either estrogen or DHT (dihydrotestosterone).
Where does Chrysin come from?
Chrysin is extracted from a fairly rare plant called
the Passiflora Caerula. => natural extract yet more
powerful than most anti-aromatase drugs you might
be familiar with.
Chrysin
« Studies done in Europe show that after
supplementing with chrysin blood serum levels of
testosterone went up 30%! »
How does this work? Chrysin basically
↓ estrogen levels by cutting down on its conversion
from testosterone.
500 mg per serving
1-3 grams of chrysin per day
= safe & effective dose.
Seranoa repens
or Saw Palmetto
1 to 3 x 160 mg/day
Saw Palmetto (Serenoa repens)
= > ↓ 5- α -reductase activity of the prostate
in vitro
Unlike other 5- α -reductase inhibitors, Serenoa repens
↓ the 5- α -reductase activity of human prostate cancer
cell lines without interfering with the cellular capacity
to secrete PSA.
=> therapeutic advantage of Serenoa repens over
other 5- α -reductase inhibitors as treatment as this
phytotherapeutic agent will permit the continuous use
of serum PSA measurements as a useful biomarker for
prostate cancer screening & for evaluating tumour
progression
Habib FK, Ross M, Ho CK, Lyons V, Chapman K. Serenoa repens (Permixon) inhibits
the 5alpha-reductase activity of human prostate cancer cell lines without interfering with
PSA expression. Int J Cancer. 2005 Mar 20;114(2):190-4
Flat hair
Flat /
Thin
hair
Improved by
Testosterone (men & women)
/estrogens (women)
IGF-1-( -GH)=> thickens hair ++
Thyroid
Flat hair
Improved by
Silicone
Flat /
Thin hair lacking Cysteine, methionine,
volume
cystine,
Flat hair
Improved by
Tribulus terrestris, Maca ,
Ginseng, Muira-puama
(→ Testosterone)
Flat /
Black cohosh, red clover, soy bean,
Thin hair yarrow, angelica (→ estrogens)
St John's Wort (Milpertuis),
Fenugreek, Licorice => IGF-1-( -GH)
Kelp, seaweeds (→ Thyroid)
Herbs to improve testosterone
Tribulus terrestris (Caltrop)
Maca
Ginseng (E.S. 5% ginsenosides)
Muira-puama
S/ 1 to 2 capsules at wake-up,
1 capsule before bedtime
250 mg
150 mg
100 mg
200 mg
TestoageLow, mimcks the action of
testosterone on the hypothalamic-pituitaryadrenal axis due to the dry extracts of
Caltrop, Maca, Ginseng & Muira-.puama.
Tribulus terrestris extract=> ↑ serum testsoterone
(+52%), DHT (31%) &DHEAS (29%) in primates
SUBJECTS: Primates, rabbit &rat
THERAPY: Tribulus terrestris (TT) extract => intravenously, as a bolus dose of
7.5, 15 and 30 mg/kg, in primates for acute study. Rabbits and normal rats were
treated with 2.5, 5 and 10mg/kg of TT extract orally for 8 weeks, for chronic study.
• In primates: ↑ serum testsoterone (+52%), DHT (31%) &DHEAS (29%) at 7.5mg/kg
were statistically significant.
• In rabbits: ↑ serum testsoterone & ↑ DHT were increased compared to control,
however, only the increases in DHT (by 30% and 32% at 5 and 10mg/kg) were
statistically significant.
• In castrated rats, increases in T levels by 51% and 25% were observed with
Testosterone & Tribulus terrestris extract respectively that were statistically sign.
CCL: TT increases some of the sex hormones, possibly due to the presence of
protodioscin in the extract. TT may be useful in mild to moderate cases of ED.
Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of
male erectile dysfunction--an evaluation using primates, rabbit and rat. Phytomedicine. 2008 Jan;15(12):44-54.
Maca
= Peruvian herb
⇒menopause relief for hot flashes & libido booster
Maca has been used by Peruvians for countless centuries,
from before the time of the Incas.
Maca => andropausal symptoms
BACKGROUND: Maca (Lepidium meyenii) = Andean plant of the brassica (mustard)
family
METHODS: Cochrane criteria.
RESULTS: 4 randomized controlled-studies met all the inclusion criteria.
• Two RCTs suggested a significant positive effect of maca on sexual dysfunction
or sexual desire in healthy menopausal women or healthy adult men,
respectively, while the other RCT failed to show any effects in healthy cyclists.
• The further RCT assessed the effects of maca in patients with erectile
dysfunction using the International Index of Erectile Dysfunction-5 & showed
sign. effects.
CONCLUSION: limited evidence for the effectiveness of maca in improving sexual
function. However, the total number of trials, the total sample size, and the average
methodological quality of the primary studies were too limited to draw firm
conclusions. More rigorous studies are warranted.
Shin BC, Lee MS, Yang EJ, Lim HS, Ernst E. Maca (L. meyenii) for improving sexual function: a
systematic review. BMC Complement Altern Med. 2010 Aug 6;10:44.
Herbs to improve GH-IGF-1
St John's Wort (Milpertuis) 200 mg
Fenugreek (D.E. 1/4)
150 mg
Licorice (Glycyrhizae Radix) 150 mg
pf/ capsule dt/ 60
S/ 1 to 3 before bedtime
According to the existing scientific data to treat the symptoms
of low levels of Growth Hormone, amino acid mix such as Larginine, L-lysine and L-ornithine ketoglutarate in addition to
the administration of plant substances stimulating GH such as
Oat and Fenugreek are recommended.
Fenugreek seeds
=> ↑↑ GH release from rat pituitary cells
SUBJECTS: rat pituitary cells
ISOLATION: from fenugreek (Trigonella foenum-graecum L.) seeds
=>isolation of 2rat growth-hormone release stimulators in vitro,
fenugreek saponin I (1), dioscin (9) &gitogenin, respectively.
o THERAPY:
Fenugreek saponin I (1) & dioscin (9) =>
• 12.5- and 17.7-fold stimulation of GH release, from rat pituitary cells,
Gitogenin (5)
• moderate activity.
Shim SH, Lee EJ, Kim JS, Kang SS, Ha H, Lee HY, Kim C, Lee JH, Son KH. Rat growth-hormone
release stimulators from fenugreek seeds. Chem Biodivers. 2008 Sep;5(9):1753-61. PubMed
Fenugreek => ↑ anabolism + no effect on androgenic activity
SUBJECTS: immature castrated male rats
THERAPY: Fenugreek (Trigonella foenum ) has long been used in the
traditional Indian medicine for the treatment of various ailments.
⇒ furostanol glycosides fraction
Fenu-FG (35 mg/kg p.o.) & testosterone (10 mg/kg, s.c. biweekly)
• increased the weight of the levator ani muscle & body weight.
Fenu-FG (10 or 35 mg/kg p.o.)
o • did not change the testosterone level in castrated rats.
• Histopathological exam of testis of non-castrated rats => Fenu-FG
(10, 35 mg/kg p.o.) => normal architecture of the testis.
• CCL Fenu-FG (35 mg/kg p.o.) => anabolic, but no androgenic activity
Aswar U, Bodhankar SL, Mohan V, Thakurdesai PA. Effect of furostanol glycosides from Trigonella
foenum-graecum on the reproductive system of male albino rats. Phytother Res. 2010
Oct;24(10):1482-8.
Brittle hair
Improved by
Brittle hair
Thyroid
Iron, B5, B7, Silicone
Short, brittle, split hair
Improved by
Short hair
Amino acid deficiencies
Iron, B5, B7, Silicone
Improved by
Brittle hair
Iron, Silicone
B5, B7
Improved by
Split hair
Iron, Silicone
Gray hair
Gray,
white
hair
• Follicular keratosis
Improved by
Thyroid hormone T3 topical
Melanotan II (MSH)
Copper
B12, PABA,
Tyrosine (→ melanine)
Cysteine, phenylalanine
Aging
Face
Pale face
Improved by
Pale Testosterone/estrogens
face Thyroid
Hypothyroidism: Pale skin
Pale skin
Esp. On extensor faces
Causes:
• Reduced blood flow <= Reflex cutaneous vasoconstriction <=
hypothermia <= Reduced metabolic rate
• Increased content of water & mucopsoysaccharides in the
dermis, which alter the refraction of light.
Freinkel RK, Freinkel N. Cutaneous manifestations of endocrine disorders. In:
fitzpatrick TB, Eisen AZ, et al. Dermatology in general medicine. 3rd edition, Ne York,
McGraw-Hill, 1987; 2063-81
Pale face
Improved by
Iron, copper
Pale face Vit. B9 (folic acid)
by anemia Vit. B12
Vit. C
Pale face
Pale
face
Improved by
Tribulus terrestris, Maca ,
Ginseng, Muira-puama
(→ Testosterone)
Black cohosh, red clover,
soy bean, yarrow, angelica
(→ estrogens)
Kelp, seaweeds
(→ Thyroid)
Herbs to improve testosterone
R/
Tribulus terrestris (Caltrop)
Maca
150 mg
Ginseng (E.S. 5% ginsenosides)
Muira-puama
200 mg
S/ 1 to 2 capsules at wake-up,
1 capsule before bedtime
x to renew
250 mg
100 mg
Muira Puama
Muira puama + Ginkgo biloba
=> improves sexual desire & performance
SUBJECTS: 202 healthy women + low sex drive
THERAPY: 1 month of Herbal formulation of Muira puama + Ginkgo biloba
(Herbal vX)
• Sign. ↑ meantotal scores from baseline in responses to selfassessment questionnaires in
65% of women
• Stat. sign. improvements => frequency of sexual desires, sexual
intercourse, &sexual fantasies, as well as in satisfaction with sex life,
intensity of sexual desires, excitement of fantasies, ability to reach
orgasm, & intensity of orgasm.
• Reported compliance and tolerability were good.
CCL: Findings support the strong anecdotal evidence for the benefits of Herbal vX on
the female sex drive
CCL: 14 days ME supplementation improved 40 km cycling time trial performance and
sexual desire in trained male cyclists => promising results
Waynberg J, Brewer S. Effects of Herbal vX on libido and sexual activity in premenopausal and
postmenopausal women. Adv Ther. 2000 Sep-Oct;17(5):255-62..
Herbs to improve estrogenic activity
R/
Blach cohosh
Red clover
Soy bean
Hop
Yarrow
Angelica
100 mg
100 mg
80 mg
75 mg
100 mg
50 mg
S/ 1 to 2 capsules at wake-up,
1 capsule before bedtime
x to renew
EstroageLow is a very effective treatment of low levels of
estrogens due to the plant extracts rich in isoflavones and
flavonoids.
Black Cohosh
= fairy candle
= summer-blooming
woodland plant that
played an important
role in patent
medicine.
Black Cohosh
= alternative to hormonal therapy to
treat hot flashes, mood
disturbances, sweating, heart
palpitations, & vaginal dryness.
Apparently, this is accomplished in the
absence of any “systemic or
breast-specific estrogenic effects.
Black Cohosh
= herb used as an alternative to estrogen-replacement therapy.
Estrogen-like properties
• provides relief in hot flashes & water retention
• May relief uterine & bladder prolapse & incontinence
• can promote energy
• sometimes dramatically improvement of depression, sadness, weeping
Progesterone-like properties
• May provide relief of breast tenderness
• Helps menstrual pain
• Tends to lessen LH
• Calming action on the nerves.
Glucocorticoid-like properties
• anti-inflammatory & anti-spasmodic properties => pain-reliever in arthritis &
rheumatism & some types of headaches
WARNING: not to use where there is severe menorrhagia or severe symptoms of
estrogen excess
Red Clover
Red Clover: Doses
Recommended Dosage
Take 1 to 2 capsules/day
of 550 mg red clover
capsules
44mg isoflavones:
- Biochanin B 23.4mg
- Biochanin A 12.7mg
- Daidzein 1.16mg
- Genistein 0.60mg. )
(providing 44 mg isoflavones)
preferably with a little liquid.
Cautions
Not recommended for use during pregnancy or breastfeeding.
Hop
=
Hop:
Medical
Use
 mainly for soothing,
sedative & calming
effects on the mind &
the body.
 treat nervousness,
anxiety & sleeplessness
(sleep enhancing effect
of hop teas)
 induce the secretion of
bile and other juices
that help the body to
digest food properly (by
the bitter flavor)
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
helps ↑gastric & other secretions.
Analgesic
anti-depressant
antibacterial, antiviral, anti-inflammatory
Antispasmodic
aphrodisiac properties
effective in fighting breast cancer, uterine
cancer & prostate cancer.
effective against a diabetes
dysentery, dyspepsia
hot flashes
irritable bowel syndrome, muscle spasm,
leprosy, leukemia
mood disturbances, nervous disorders
restlessness
silicosis
skin disorders.
Hop: dosage
• As a sedative: Dosage is 500 to 1,000 mg of dried
herb by mouth, taken as a single dose. It may also be
taken as tea, which is prepared by brewing dried
herb in 5 oz of boiling water for 5 to 10 minutes, and
then straining
Soy
Daidzein
Daidzein
Formula
C15H10O4
Mol. Mass 254.237 g/mol
Daidzein = Isoflavones => found in plants
=> primary food source = soybeans & soy products like tofu &
textured vegetable protein
Soy isoflavones
= compounds isolated from the soybean
Wikipedia, the free encyclopedia
Genistein
Genistein
Formula
C15H10O5
Mol. Mass
270.241 g/mol
Genistein = Isoflavones => found in plants
=> primary food source = soybeans & soy products like tofu &
textured vegetable protein
Soy isoflavones
= compounds isolated from the soybean
Wikipedia, the free encyclopedia
Insufficient sun tan
Improved by
Melanotan II, I
& PT141
Insufficient Testosterone
sun tan
Tyrosine
(→ melanine)
Vit. D
Swollen face
Improved by
Thyroid
Swollen
lower eyelids (Progesterone)
Improved by
Swollen Thyroid
face
Swollen face
Improved by
Thyroid
Swollen
lower eyelids (Progesterone)
Improved by
Swollen Thyroid
face
Reversing Physical Aging
with Thyroid Therapy
• ↓Diffuse hair loss all over the head
• ↓ Dry, rough , split hair
• No or slight regrowth of
outer 3rd of the eyebrow
• ↓ ↓ swollen
lower eyelids
• ↓ dry skin
Untreated
Thyroid
deficiency
Suborbital
edema
Thyroid
therapy
↓ ↓ suborbital
edema
Hollow face, age spots
Pigmented
age spots
Hollow
face
Improved by
Methyl(prednisolone)
(Hydrocortisone)
Improved by
Hydrocortisone
((methyl)prednisolone)
(Testosterone)
Addison's
Disease
Head of Thomas
Clouston.
A single capsule
diseased.
Reversal of Physical Aging
By Hydrocortisone/Glucocorticoid treatment
Cortisol deficiency
Cortisol treatment
• More relaxed,
↓ irritable look
• ↓ Enflammed eyes
(scleritis,
conjunctivitis)
• ↓ Dark circles
under the eyes
• No hollow
cheeks
• No age
spots
Pigmented age spots
Improved by
Pycnogenol
Selenium
Pigmented
Vit. E
age spots
Vit. A
Zinc
Daily dose
3x 50 mg
2 x 200 µg
2x 400 mg
2x 50 000 IU
2x 25 mg
Hollow face
Improved by
Licorice, Ginseng, Ecchinacea,
Pigmented
Helichrysum, Sarsaparilla
age spots
(→ cortisol)
Improved by
Licorice, Ginseng, Ecchinacea,
Helichrysum, Salsaparilla (→ cortisol)
Hollow
face (Tribulus terrestris, Maca ,
Ginseng, Muira-puama
(→ Testosterone))
Herbs to improve cortisol
Licorice (10% glycirrhetic acide )
Ginseng (E.S. 0.4 % eleuteroside)
Ecchinacea
Helichrysum
Salsaparilla
S/ 1 to 2 capsules at wake-up,
1 capsule before bedtime
400 mg
100 mg
75 mg
75 mg
25 mg
Low levels of cortisol can be successfully treated by
administering immunostimulatory plants such as Echinacea
and Italian everlasting, substances rich in steroidal saponins
such as Honduras sarsaparilla and Siberian Ginseng in
addition to substances which inhibit the degradation of
cortisol such as Liquorice.
Licorice
Licorice
Corruption of the Greek name glyrrhiza => the other official
name, Liquiritra officinalis; the medieval name was gliquiricia
from which the name licorice or liquorice is obtained.
Licorice => > 2x ↑ urinary cortisol in healthy people
SUBJECTS: 13 normal volunteers => ate either
THERAPY: consumption of 100 or 200 g/day of licorice for 1-4 weeks
• > 2x ↑ urine cortisol excretion in 10 of 13 subjects (mean, 33.8 before & 83.3
µg/24 h at 1 week after commencing licorice) => excretion rates similar to
Cushing's syndrome in 7 subjects (range, 91-226, vs nl = 11-82 µgrams/24 h).
• Urine cortisol excretion remained sign. ↑ (P <0.01) above control levels for at
least 1 week after licorice was withdrawn.
• No change of urinary steroid metabolite (tetrahydrocortisol, tetrahydrocortisone,
tetrahydro-11-deoxycortisol, 17-ketogenicsteroids, &17-ketosteroids) excretion
• No change of serum cortisol & ACTH
• Normal 0800-1600-h diurnal variation of plasma cortisol was maintained
Direct intraadrenal infusion of the active mineralocorticoid component of licorice,
glycyrrhetinic acid => 2 sheep with autotransplanted adrenal glands
• failed to stimulate cortisol secretion acutely.
CCL: Licorice-induced changes in cortisol excretion ≠ result of adrenocortical
stimulation but more likely represent a change in the renal handling of cortisol.
Epstein MT, Espiner EA, Donald RA, Hughes H, Cowles RJ, Lun S. Licorice raises urinary cortisol in
man. J Clin Endocrinol Metab. 1978 Aug;47(2):397-400.
Grapefruit juice & licorice => ↑ cortisol availability
in patients with Addison's disease
SUBJECTS: Patients with Addison's disease on stable cortisone acetate (CA) therapy
=> Check of serum cortisol in the first 2.6 h after orall cortisone acetate
THERAPY : Licorice & grapefruit juice (GFJ) on the absorption and metabolism of
cortisone acetate (CA) (vs controls): 2.6 h after tablet ingestion
• + 5.5% ↑ median AUC for serum cortisol with licorice (53 783 vs 50 882, P<0.05)
• + 17 % ↑ median AUC for serum cortisol w/grapefruit juice (60 661 vs 50 882,
P<0.05)
• + 20% ↑ median serum cortisol levels with licorice (223 vs 186 nmol/l, P<0.05)
• + 81% ↑ median serum cortisol levels w/grapefruit juice 337 vs 186 nmol/l, P<0.01).
• +104% ↑ median urinary cortisol/cortisone ratio w/ licorice (0.43 vs 0.21,
P<0.00001)
• whereas GFJ increased the (allo-tetrahydrocortisol + tetrahydrocortisol)
/tetrahydrocortisone ratio (0.55 vs 0.43, P<0.05).
CCL: Licorice and in part. Grapefruit juice => ↑ cortisol available to tissues in the hours
following oral CA administration
Methlie P, Husebye EE, Hustad S, Lien EA, Løvås K. Grapefruit juice and licorice increase cortisol availability
in patients with Addison's disease. Eur J Endocrinol. 2011 Nov;165(5):761-9.
Echinacea
Echinacea
=> stimulant of the adrenal cortex
MOSTBECK A, STUDLAR M. [Experimental tests of a plant extract from Echinacea
purpurea Moench as a nonspecific stimulant. With special reference to the effects on
the adrenal cortex]. Wien Med Wochenschr. 1962 Mar 31;112:259-62.
Helichrysum
Helichrysum italicum or Helichrysum angustifolium is a
flowering plant of the daisy family Asteraceae.
It is sometimes called the curry plant because of the strong smell
of its leaves.
It grows on dry, rocky or sandy ground around the Mediterranean.
Oleanolic &ursolic acid fraction from Helichrysum
=> Anti-inflammatory (antihistaminic &
antieicosanoid effects)
HELICHRYSUM: triterpene isomers ursolic and oleanolic acids
• inhibited compound 48/80-induced histamine release from rat peritoneal mast
cells in an approxi. % percentage of 45% at 100 µM and myeloperoxidase
secretion from A23187-ionophore-stimulated rat peritoneal leukocytes in a
significant manner at doses of 50 and 100 µM. F
• very sign. & dose-depe. inhibited generation of the cyclo-oxygenase metabolite
prostaglandin E2 (41% inhibition at 50 ùM) and the 5-lipoxygenase metabolite
leukotriene B4 (79% inhibition at 50 µM) from activated rat leukocytes => antieicosanoid activity =more potent than that produced by the pure triterpene
oleanolic acid used for comparision, indicating a stronger action of the ursolic
acid, the major compound of the isolated triterpene fraction
CCL: the triterpene isomers oleanolic & ursolic acids present in the medicinal plant
Helichrysum picardii => anti-inflammatory
Santos Rosa C, García Gimenez MD, Saenz Rodriguez MT, De la Puerta Vazquez R.
Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from
Helichrysum picardii. Pharmazie. 2007 Jun;62(6):459-62.
Sarsaparilla
Sarsaparilla organic acid
=> cortisol-like activity
ISOLATION: An organic acid, isolated and purified from the root extract of an Indian
medicinal plant sarsaparilla Hemidesmus indicus R. Br => viper venom inhibitory activity.
The compound (designated HI-RVIF) was isolated by solvent extraction, silica gel column
chromatography and thin layer chromatography, and was homogeneous in nature.
SUBJECTS: RODENTS:
THERAPY: HI-RVIF from root extract of sarsaparilla => sign. antagonized viper venominduced
– Lethal
– Haemorrhagic
– Coagulant
– Anticoagulant activity.
Alam MI, Auddy B, Gomes A. Isolation, purification and partial characterization of viper
venom inhibiting factor from the root extract of the Indian medicinal plant sarsaparilla
(Hemidesmus indicus R. Br.). Toxicon. 1994 Dec;32(12):1551-7.
Eyes
Improved by
Cataract
+ GH
& IGF-1 in
mesotherapy
Growth hormone
Melatonin
Improved by
Droopy Growth hormone
eyelids IGF-1
+ Growth
hormone
& IGF-1 in
mesotherapy
Eyes
Improved by
Cataract,
macular degeneration
Vit. E
Vit. A
Zinc
Improved by
Droopy Amino acid
eyelids deficiency
Eyes
Improved by
Cataract
St John's Wort (Milpertuis), Fenugreek,
Licorice => IGF-1-( -GH)
Chasteberry => Melatonin
Improved by
Droopy
eyelids
St John's Wort (Milpertuis),
Fenugreek, Licorice => IGF-1-( -GH)
Chaste Berry: sleep
Taking chasteberry shortly before bedtime:
•
may increase early morning melatonin
secretion
•
improve sleep.
Melatoninstimulating
effects
Eyes
Improved by
Estrogen
Dry
eyes
Testosterone, DHEA
Vit. A
Omega-6 deficiencies
Eyes
Improved by
Black cohosh, red clover, soy
bean, yarrow, angelica
(→ estrogens)
Tribulus terrestris, Maca ,
Dry eyes
Ginseng, Muira-puama
(→ Testosterone)
Tribulus terrestris, wild yam,
(→ DHEA)
Herbs to improve DHEA effects
Tribulus terrestris (Caltrop) 250 mg
Dioscorea (Wild yam)
250 mg
pf/ capsule dt/ 60
S/ 1 to 2 at wake-up, 1 before bedtime
Tribulus terrestris
Tribulus terrestris (Caltrop)
=> ↓ ischemia-reperfusion injury in rat brain
SUBJECTS: rats
THERAPY: injectable caltrop fruit saponin preparation (ICFSP) => ↓ ischemiareperfusion injury in rat brain
• ↓ infarct size (p < 0.01)
• ↓ neurological deficit score (p < 0.05)
• ↓ plasma content of thromboxane B2 (TXB2) & endothelin (ET) (p < 0.05)
• ↓ malondialdehyde (MDA) & nitric oxide (NO) content
• improved forelimb function.
• ↑ plasma level of 6-K-PGF 1α (vasoactive factor; p < 0.05)
• ↑ superoxide dismutase (SOD) activity in cerebrum
• a similar potency compared to that of Ligustrazine hydrochloride parenteral
solution (LHPS) and nimodipine (Nim).
Yan LG, Lu Y, Zheng SZ, Wang AY, Li MQ, Ruan JS, Zhang L. Injectable caltrop fruit saponin protects against
ischemia-reperfusion injury in rat brain. Am J Chin Med. 2011;39(2):325-33.
Wild yam
= Dioscorea villosa = Colic Root = Rheumatism Root =>
widely used within the herbal tradition, primarily for its
spasmolytic properties, esp. in the large intestine &
uterus
Can wild yam (dioscorea) supplements =>↑serum
DHEA sulfate in humans & improve lipid levels
Subjects: Older people aged 65-82 years.
THERAPY: 3weeks of dioscorea supplementation had
Serum DHEA sulfate
Serum HDL
serum lipid peroxidation
serum triglycerides
Serum phospholipids
Wild yam
No effect
Sign. ↑
Sign. ↓
Sign. ↓
Sign. ↓
85 mg/day DHEA therapy
↑ + 100.3 %
Sign. ↑
Sign. ↓
Sign. ↓
Sign. ↓
Araghiniknam M, Chung S, Nelson-White T, Eskelson C, Watson RR. Antioxidant activity of
dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci.
1996;59(11):PL147-57
Eyes
Improved by
(Methyl)prednisolone ((4) 5 mg)
Hydrocortisone
Enflammed
Enflammed conjunctives:
eyes
Omega-3 fatty acids (2 to 4 g/day)
Enflammed eye globe: Vitamin B2-B6
Improved by
Dark circles
under the eyes
(Methyl)prednisolone ((4) 5 mg)
Hydrocortisone
Eyes
Improved by
Licorice, Ginseng, Ecchinacea,
Enflammed
Helichrysum, Sarsaparilla
eyes
(→ cortisol)
Improved by
Dark circles Licorice, Ginseng, Ecchinacea,
under the Helichrysum, Sarsaparilla
eyes
(→ cortisol)
Wrinkles
Improved by
Desmopressin-vasopressin
Sunken
eyes
Fludrocortisone-aldosterne
Water
Sodium
Improved by
Fludrocortisone-aldosterone
Crow feet
wrinkles
Desmopressin-vasopressin
Water
Sodium
Reversal of Physical Aging
by Desmopressin treatment
Desmopressin =>
• ↓ Sunken eyes
• ↓ Crow feet wrinkles
• ↓ Very small folds in the s
• ↓ Sharp wrinkles
Reversal of Physical Aging by
Fludrocortisone/ Aldosterone treatment
• ↓ Sunken eyes
Aldosterone deficiency
Fludrocortisone treatment
• ↓ Crow feet wrinkles
• Smooth tongue
(with NO indentations)
• No sharp wrinkles
Thin or Thick Lips
Thin lips
Normal lips
Thin
lips
Reversed by
Middle Growth hormone,
IGF-1
Outer Growth hormone,
IGF-1
Amino acid mixtures
Swollen lips (esp.
In middle part)
Reversed by
Thyroid
Iodine
Tyrosine
Lip thinning with thyroid treatment
Thin or Thick Lips
Thin lips
Normal lips
Thin
lips
Reversed by
Middle St John's Wort
Outer (Milpertuis),
Fenugreek, Licorice
=> IGF-1-( -GH)
Reversed by
Swollen lips (esp. In Kelp, seaweeds
middle part)
(→ Thyroid)
Eyebrows, cheeks
Improved by
Thinning or
disappearing
eyebrow
Inner
DHT , testosterone
Middle Growth hormone, IGF-1
Outer
Thyroid
Improved by
Less firm
cheeks
Growth hormone, IGF-1
Testosterone
Improved by
Jaw bone
atrophy
Growth hormone, IGF-1
Testosterone
↑
↑ serum testo.=>
salivary testosterone => ↑ eyebrows
globally longer
face in adulthood, but prominent
lower face if ↑ prenatal testo
Prenatal & pubertal testosterone => differential effects on male
facial shape
• ↑ early androgen action : ↑ prenatal testosterone
=> relatively robust & prominent lower face
• ↑ adult serum testosteorne
=> uniform elongation of the face
• ↑ adult salivary testosterone => ↑ eyebrows (pronounced &
medially tailed)
Schaefer K, Fink B, Mitteroecker P, Neave N, Bookstein FL. Visualizing facial shape regression
upon 2nd to 4th digit ratio and testosterone. Coll Antropol. 2005 Dec;29(2):415-9.
Eyebrows,
cheeks
Improved by
Inner
Thinning or
disappearing
eyebrow
Red meat intake (↑ DHT)
Middle Amino acid, esp. leucine,
valine, isoleucine, glutamine,
Outer
Tyrosine, iodine
Improved by
Less firm
cheeks
Amino acid, esp. leucine, valine,
isoleucine, glutamine
Improved by
Jaw bone atrophy
Amino acid, esp. leucine, valine,
isoleucine, glutamine,
Eyebrows,
cheeks
Improved by
Thinning or
disappearing
eyebrow
Inner
Red meat intake (↑ DHT)
Middle St John's Wort (Milpertuis),
Fenugreek, Licorice
(=> IGF-1 -GH)
Outer
Kelp, seaweeds (→ Thyroid)
Improved by
Less
firm
cheeks
St John's Wort (Milpertuis), Fenugreek,
Licorice (=> IGF-1 -GH)
Tribulus terrestris, Maca ,
Ginseng, Muira-puama (→ Testosterone)
Improved by
St John's Wort (Milpertuis), Fenugreek, Licorice
(=> IGF-1 -GH)
Jaw
bone
atrophy Tribulus terrestris, Maca ,
Ginseng, Muira-puama (→ Testosterone)
Improved by
Growth hormone
Wrinkles
IGF-1
Forehead
wrinkles
Amino acids esp. Glutamine &
branched chain AA such as valine,
leucine, isoleucine
Elasticity nutrients: Glycine,
threonine, vit. C, vit. D, zinc
Improved by
Growth hormone
IGF-1
Large
Testosterone
wrinkles Amino acids esp. glutamine & branched chain AA such
as valine, leucine, isoleucine
Elasticity nutrients: Glycine, threonine, vit. C, vit. D, zinc
Growth hormone
takes wrinkles away
Reversal of Physical Aging by
Growth hormone, IGF-1 & Testosterone treatment
• ↓ Upper head (vertex) hair loss
• Thicker hair , more hair volume
• Thicker inner eyebrows
• ↑ humid eyes
• ↑ color in the FACE
• Younger, firmer FACE
• ↓ Dry skin
• ↑ firmer muscles
Wrinkles
Improved by
Forehead
wrinkles
Large
wrinkles
St John's Wort (Milpertuis),
Fenugreek, Licorice
=> IGF-1-GH)
Improved by
St John's Wort (Milpertuis),
Fenugreek, Licorice
(→ IGF-1-GH)
Tribulus terrestris, Maca ,
Ginseng, Muira-puama
(→ Testosterone)
Wrinkles
Improved by
Small wrinkles;
Wrinkles above
the upper lip
Estrogen,
progesterone
Testosterone
Estradiol,
progesterone
Untreated
Sex Hormone +Testosterone
therapy
deficiency
Skin
Mucosa
Muscle
atrophy
↓Skin
Mucosa
Muscle
atrophy
Wrinkles
Improved by
Small wrinkles
Wrinkles above
the upper lip
Black cohosh, red clover, soy bean, yarrow,
angelica (→ estrogens)
Chasteberry , wild yam, yarrow, lady
mantle, unicorn (→ progesterone)
Tribulus terrestris, Maca ,
Ginseng, Muira-puama (→ Ttestosterone)
Herbs believed to promote
progesterone balance
•
•
•
•
•
•
Chaste Berry (Vitex Agnus Castus )
Wild Yam
Yarrow
False unicorn
Black haw
Lady’s Mantle
Whereas low levels of Estrogens can be
increased by a number of natural
substances, low levels of progesterone can
be treated in particular by 2 plants, Wild
yam and Agnus castus.
Chaste Berry (Vitex agnus castus)
Medieval monks were said to have eaten the berries to reduce sexual desire, hence
the name Chaste Tree or Monks Pepper. Ancient Europeans used the berries to treat
hemorrhage following childbirth & menstrual regulation. It was also used for
injuries & inflammation & to encourage milk flow after birth.
Chaste Berry: Ingredients
No one constituent of chaste tree has been isolated as responsible for its
medicinal effects.
The berries contain iridoids as glycosides, including aucubin & agnuside.
Flavonoid content is highest in the leaves (up to 2.7 %) & flowers (nearly
1.5 %).
The berries contain almost 1 % of flavonoids such as casticin, isovitexin,
orientin, kaempferol, & quercetagetin.
It is perhaps surprising that chaste tree does
not contain plant
estrogens.
Instead, progesterone, hydroxyprogesterone,
testosterone, epitestosterone, & androstenedione
have been identified in the leaves & flowers.
The essential oil of chasteberry may be responsible for its distinctive spicy
aroma. It contains monoterpenes cineol and pinene, along + limonene,
eucalptol, myrcene, linalool, castine, citronellol, & others, plus several
sesquiterpenes.
An alkaloid, vitricine, is also an ingredient.
Progesterone
dominance
Chaste Berry: clinical trials
Glucoc.-like
Tincture (fresh ripe berries pounded to a pulp)
• relief of paralysis, pains in the limbs, weakness,
effects
• Relief of breast pain,
• Menstrual regulation
• Treatment of hemorrhage
Clinical trials => prolonged use of Chaste &Tree Berries
Progesterone• Sign. reduces a range of PMS symptoms, from irritability &
like effects
headaches to cramping & breast pain.
• ↑ proliferative (first) phase of the menstrual cycle
• ↓ water weight, headache & fatigue
• mild effectiveness for women + infertility & irregular periods
E2-like effects
• ↓ hot flashes in the peri-or post menopause.
Some studies => berries = antiandrogenic
• ↓ acne in men & women
• ↓ overactive libido.
Progesterone-like
Vitex (Chaste Berry) => pituitary gland
• ↑ LH, => re-establishes the normal balance between estrogen
or -stimulating
& progesterone, thereby regulating a women‘s cycle
effects
Progesterone cream => ↑ skin elasticity & firmness,
↓ wrinkles
SUBJECTS: 40 peri- & post-menopausal women => double-blind study :
TREATMENT: 16 weeks of 2 % progesterone cream (vs placebo) ↓ ↓
• Sign. ↑ of the elastic skin properties, as demonstrated by objective measurements of
three skin elasticity parameters (P < or = 0.05)  control group: no such effect.
• greater ↓ in wrinkle counts (29.10% vs. 16.50%) & wrinkle depth (9.72% vs. 7.35%)
around the right eye
• greater ↓ in nasolabial wrinkle depth (9.72% vs. 6.62%)
• Sign. ↑ (P < 0.05) increase in skin firmness (23.61% vs.13.24%) in the treatment group.
• no sign. diff. in epidermal hydration & skin surface lipids in either group
• Progesterone was well absorbed in the systemic circulation: mean blood levels rose
minimally, but stat. significantly (P = 0.001), by 0.53 ng/m
• No serious side-effects of the treatment were observed.
Holzer G, Riegler E, Hönigsmann H, Farokhnia S, Schmidt JB. Effects and side-effects of 2%
progesterone cream on the skin of peri- and postmenopausal women: results from a doubleblind, vehicle-controlled, randomized study. Br J Dermatol. 2005 Sep;153(3):626-34
DHEA => ↓ aging skin
in postmenopasual women
SUBJECTS: 2 groups of 20 post-menopausal women
RESULTS: topical DHEA 1% during 4 months => facial & hand skin
(vs placebo-vehicle)
• ↑ rate of sebum => perceived rather positively by a menopausal population
usually affected with ↓ sebum level.
• ↑ skin brightness
• counteract papery appearance of skin & epidermal atrophy, a
characteristic feature of hormone-related skin aging.
• also acts on skin process related to wrinkles, but this result remains to be
confirmed. ↑
Nouveau S, Bastien P, Baldo F, de Lacharriere O. Effects of topical DHEA on aging skin: a pilot study. Maturitas. 2008 Feb
20;59(2):174-81. L'Oréal-Recherche, 90 rue du Général Roguet, 92583 Clichy Cedex, France.
Lack of fat in the face
Insulin deficiency?
Partial lipoatrophy affecting
the face, producing a gaunt
‘cadaverous’ appearance
due to easily visible
underlying bony structures.
(Courtesy of Theodore
Sebastian, MD.)
http://images.google.be/imgres?imgurl=http://a248.e.akamai.net/7/248/430/20051209025323/www.merckmed
icus.com/ppdocs/us/hcp/content/white/chapters/images/f018011.jpg&imgrefurl=http://www.merckmedicus.co
m/ppdocs/us/hcp/content/white/chapters/white-ch-018s002.htm&h=764&w=500&sz=75&hl=fr&start=17&tbnid=eeE3e2ewJgYMLM:&tbnh=142&tbnw=93&prev=/image
E-mail /// Hormone Handbook
• For copy of the slides:
• ask at
medschool@hertoghe.eu
Thank you
for your attention