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Board of Directors Gerald Chan, Morningside Associates Inc. Boston/Shanghai Maoyen Chi, Cold Spring Harbor Laboratory (CEO) Terri Grodzicker, Cold Spring Harbor Laboratory John Maroney, Cold Spring Harbor Laboratory (Secretary) Lari Russo, Cold Spring Harbor Laboratory (Treasurer) David J. Stewart, Cold Spring Harbor Laboratory (President) Rui-ming Xu, Chinese Academy of Sciences (Vice-President) CSH Asia Staff David J. Stewart, President Maoyen Chi, Chief Executive Officer Xi Shen, Program Coordinator Dorothy Zhang, Business Administrator & Registrar Mike Ji, Corporate & Sponsorship Program Administrator Will Wang, IT Engineer Aileen Wu, Administrative Assistant Queenie Xue, Administrative Assistant Susan Lu, Accoutant Contributing Cold Spring Harbor Laboratory Staff Drew Mendelsohn, Director Marketing, Planning & IT Val Pakaluk, Assistant to the Executive Director Mary Smith, Abstract Manager Marge Stellabotte, Finance Coordinator Katiria Ceballos, Programmer Credits Maoyen Chi, Chief Designer Xi Shen, Editor Bifeng Li, Art Designer Cold Spring Harbor Asia No.299 Qiyue Road Suzhou Industrail Park, Jiangsu China 215123 Phone: +86 512 6272 9029 Fax: +86 512 6272 9028 Email: meetings@csh-asia.org Internet: http://www.csh-asia.org 2012 Conference and Course Program WE APPRECIATE THE GENEROUS SUPPORT FROM OUR SINCERE APPRECIATION TO 感谢下述单位慷慨资助 大力鸣谢 China Novartis Institutes For Biomedical Research Co., Ltd The Company Of Biologists Ltd Suzhou Association For Science And Technology Glaxosmithkline (China) R&D Co., Ltd. The Children'S Hospital Corporation Nanjing Genscript Epizyme, Inc The Company Of Biologists Ltd "Otogenetics Corporation" Wuxi Newway Bio-Tech Co.,Ltd. Stemcell Technologies Inc. Beijing Rep Berry Genomics Co., Ltd. Thermo Fisher Scientific (China) Co., Ltd. Guangzhou Institutes Of Biomedicine And Health, Cas Active Motif, Inc. Abcam (Hong Kong) Limited The Children'S Hospital Corporation Qiagen China (Shanghai) Co Ltd Novartis Pharma Ag Shanghai Zhenyu Instrument Co., Ltd. Biowish Shanghai Haisheng Industrial & Trading Co., Ltd. Abmart Inc. Olympus China Co., Ltd Thermo Fisher Bio Chemical Products Beijing Co., Ltd. Hashimoto Electronic Industry Co., Ltd. Life Science Methods Invitrogen Shanghai Trading Co., Ltd. Qingdao Samuels Industrial & Commercial Co., Ltd. Viewpoint Union Biometrica Inc The Children'S Hospital Corporation Aquatic Habitats Inc Tecniplast Spa Nikkyo Technos Co Ltd Leica Micro Systems Aquaneering Hangzhou Sigma Biotech Co., Ltd. SUZHOU INDUSTRIAL PARK ADMINISTRATIVE COMMITTEE 蘇州工業園區管委會 COLD SPRING HARBOR ASIA , CSHA CEO S REPORT 冷泉港亞洲 冷泉港亞洲首席執行官報告 2012 CSHA President’s Report The pace of change in biological and biomedical sciences in laboratories around the world is stunning. Every agency, whether governmental or private, that supports these endeavors has to balance the impact on human health, agriculture and the environment with hard-to-evaluate blue skies research which may have no immediate payoff. Cold Spring Harbor Laboratory’s scientists have long pursued fundamental biological research, and this effort is reflected in our educational programs that focus on basic biological processes such as transcription, RNA processing and protein synthesis or methodological approaches such as imaging, electrophysiology, proteomics or X-ray crystallography. Increasingly, however, translational or applied approaches that are much closer to the clinic or the farm make appearances at the Laboratory’s meetings and courses in the form of individual talks, sessions or even themes of an entire program. This is a good thing, because it exposes young scientists to the idea that what they do may have real societal impact in the years ahead. But too much of a good thing can be bad, and excessive emphasis on outcomes may be counterproductive, because the freedom to experiment becomes relegated to a distant second place. and eventual pay-off. We need to ensure that CSHA conferences provide opportunities to share and discuss new discoveries and findings, irrespective of their immediate monetary or societal value. This is not to argue that scientific research should simply be funded for its own sake, but rather because the next research breakthrough is inherently unpredictable – we simply cannot say from where the next discovery will appear. Predictions about the future of society even a few years hence are notoriously unreliable; predictions about future scientific discoveries are probably even more fanciful. Scientists young and old must be allowed – at least to some extent - to be driven by their curiosity, rather than by the strategic plans of funding agencies or government departments. The next big thing is just around the corner, only none of us know what it will be, or around which corner it may come. 2012 marks an expansion of CSHA. The total number of our meeting has grown to 17, which is a significant expansion from 13 in 2011.Expansion naturally comes with challenges. And the challenges that CSHA faced in 2012 were not only in the operational level, but most importantly were in terms of the quality and nature of our meetings. The following highlights are some of our answers to those challenges: Integration of Science from the Asia-Pacific Region Right in the beginning of CSHA's establishment, we strongly believed that CSHA's scientific meeting programs should reflect the latest scientific progress in the Asia-Pacific region. Besides, CSHA should be, and ought to be, an open and neutral platform for all scientists throughout this region to organize meetings for their research topics, to present their data and to discuss their works. In the past three years, most of our meetings were predominantly occupied by science from outside of this region. With the rapid expansion of CSHA's conference list in 2012, eventually we were able to assimilate the latest research from this region into our programs by reaching out more local scientific communities. For example, the conference on “bone and cartilage biology” was a direct result of a visit to a Korea University that was ended by a proposal from a Korean scientist who had been looking for organization to host meeting for this growing community. Meetings in plant epigenetics and ion channel were results of interactions with teams of Chinese scientists in various schools. And the meeting on neural circuits and behavior was brewed during a visit to a Japanese lab.All these examples represented CSHA efforts in committing itself as an open and neutral platform for scientific discussion. In Cold Spring Harbor Asia’s third year of operation, it is noteworthy that the academic program of conferences shares this dichotomy between basic and applied research, with some events focused on the fundamentals such as RNA biology, epigenetics or plant stress, while others address diseases in the liver, bone & cartilage, or the immune system. While CSHA programs should indeed explore pathways of research that may yield new therapeutics, diagnostics and other products of benefit to humankind, we should not ignore the value – and excitement - of discovery in its own right. Investigating the unknown is unpredictable and risky, since the outcome cannot be known ahead of time, but may be immensely rewarding both in terms of intellectual curiosity 2012 summary David J. Stewart, Ph.D. President, CSH Asia CSHA Meetings with More Asian Characters As the sole scientific meeting program in the Asia-Pacific region, CSHA understands its irreplaceable and indispensible role in promoting science with regional characters within its programs. In addition to adding more meetings to our list from local communities, CSHA also tried to organize meetings with topics unique, or especially interested in the Asia-Pacific region. Meetings in infectious diseases, liver metabolism and diseases are examples that fall into this category. And we are committed to organize more meetings in those Asia specific areas in the years to come. Make CSHA More Accessible to Local Students In the past 3 years, we have spent a great deal of our energy in understanding the particular needs from local schools and students in order to make our programs more accessible and more helpful to them. As a result, in 2012 we renewed an even more generous package called “Watson Program”, or WP, in addition to many existing packages that are tailormade to local students. WP basically is a free auditing mechanism for students at the very beginning of their scientific career. They come to CSHA's meeting in an organized and chaperoned way. This mechanism not only lowers the hurdle of CSHA's meetings to local students, but more importantly it ensures the students participation in CSHA's meeting in a more responsible and beneficial way. After roughly a year's practice, this program has became so popular that more than 40 top Chinese universities have entered agreements with CSHA. And towards the end of 2012, CSHA has also applied this program to students from Hong Kong and Taiwan. Now we are also considering the possibility of open WP to students in Korea, Singapore and beyond. Maoyen Chi, Ph.D. CEO, CSH Asia 2012 Conference and Course Program FISHING FOR ANSWERS: ZEBRAFISH MODELS OF HUMAN DEVELOPMENT AND DISEASE 以魚求解:人類發育與疾病的斑馬魚模型 HEMATOPOIESIS J. Zhu, Sino-French Research Center for Life Sciences and Genomics, Shanghai, China A.T. Look, Dana-Farber Cancer Institute, Boston, Massachusetts, USA DISEASE MODELS II April 16 - 20 T. Zhong, Fudan University, Shanghai, China H. Spaink, Leiden University, the Netherlands 259 Participants ORGANIZED BY Koichi Kawakami, National Institute of Genetics, Japan 日本國立遺傳學研究所 A. Thomas Look, Dana Farber Cancer Institute, USA 美國Dana-Farber 癌症中心 Elizabeth Patton, Medical Research Council, Edinburgh, UK 英國醫學研究理事會 Jinrong Peng, Zhejiang University, China 中國浙江大學 Leonard Zon, HHMI/Children's Hospital Boston, USA 美國霍華德休斯醫學研究院/美國波士頓兒童 醫院 PROGRAM DISEASE MODELS I F. Liu, Institute of Zoology, CAS, Beijing, China E. Patton, MRC Human Genetics Unit, Edinburgh, United Kingdom CANCER BIOLOGY AND GENETICS H. Hirata, National Institute of Genetics, Mishima, Japan L. Zon, Howard Hughes Medical Institute, Children’s Hospital, Boston, Massachusetts, USA CANCER AND SIGNAL TRANSDUCTION I C.-D. Hsiao, Chung Yuan Christian University, Chung-Li, Taiwan M. Mione, Karlsruhe Institute of Technology, Germany INNATE IMMUNITY AND HEMATOPOIESIS Y.-J. Chuang, National Tsing Hua University, Hsinchu, Taiwan J. Peng, Zhejiang University, Hangzhou, China CANCER AND DEVELOPMENTSL BIOLOGY Y. Zhou, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China N. Trede, Huntsman Cancer Institute, Salt Lake City, Utah, USA TISSUE DEVELOPMENT AND ORGANOGENESIS H. Wang, Soochow University, Suzhou, China K. Kawakami, National Institute of Genetics, Mishima, Japan 1 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia KEYNOTE SPEAKERS Philip W. Ingham, Institute of Molecular and Cell Biology, SINGAPORE 新加坡分子與細胞生物學研究所 David P. Lane, A*STAR, SINGAPORE 新加坡科技研究局 Shuo Lin, University of California, Los Angeles, USA 美國加州大學洛杉磯分校 Manfred Schartl, Biocenter of the University Wuerzburg, GERMANY 德國維爾茨堡大學 INVITED SPEAKERS James F. Amatruda, UT Southwestern Medical Center, USA 美國田納西大學西南醫學中心 Keith C. Cheng, Penn State College of Medicine, USA 美國賓州州立大學醫學院 Philip S. Crosier, University of Auckland School of Medicine, NEW ZEALAND 新西蘭奧克蘭大學醫學院 Peter D. Currie, Monash University, AUSTRALIA 澳大利亞莫納什大學 Wolfram Goessling, Brigham and Women's Hospital, USA 美國布裏格姆婦女醫院 Zhiyuan Gong, National University of Singapore, SINGAPORE 新加坡國立大學 Philippe Herbomel, Institut Pasteur, France 法國巴斯德研究所 Jeroen den Hertog, Hubrecht Laboratory, NETHERLANDS荷蘭Hubrecht實驗室 Joan K. Heath, Ludwig Institute for Cancer Research, AUSTRALIA 澳大利亞路德維希癌症研究所 Koichi Kawakami, National Institute of Genetics, Japan 日本國立遺伝學研究所 David M. Langenau, Harvard Medical School, USA 美國哈佛大學醫學院 Graham J. Lieschke, Monash University, AUSTRALIA 澳大利亞莫納什大學 Thomas Look, Dana Farber Cancer Institute, USA 美國達納-法伯癌症研究所 Anming Meng, Tsinghua University, CHINA 中國清華大學 Marina C. Mione, Karlsruhe Institute of Technology, GERMANY 德國卡爾斯魯厄理工學院 Trista E. North, Harvard Medical School, USA 美國哈佛大學醫學院 E. Elizabeth Patton, Medical Research Council, Edinburgh, UK 英國醫學研究理事會 Jinrong Peng, Zhejiang University, CHINA 中國浙江大學 Lalita Ramakrishnan, University of Washington, USA 美國華盛頓大學 Stefan Schulte-Merker, Hubrecht Institute, THE NETHERLANDS 荷蘭Hubrecht研究所 B Ewa Snaar-Jagalska, Leiden University, NETHERLANDS 荷蘭萊頓大學 Herman P. Spaink, Leiden University, NETHERLANDS 荷蘭萊頓大學 David Traver, University of California, San Diego, USA 美國加州大學聖地牙哥分校 Nikolaus S. Trede, University of Utah, USA 美國猶他大學 Astrid M. van der Sar, VU university medical center, NETHERLANDS 荷蘭VU大學醫學中心 Zilong Wen, Hong Kong University of Science and Technology, CHINA 香港科技大學 Jen-Leih Wu, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, TAIWAN 臺灣中央研究院細胞與個體生物學研究所 Yong Zhou, Shanghai Institutes for Biological Sciences, CHINA 中國上海生命科學研究院 Leonard I. Zon, HHMI/Children's Hospital Boston, USA 霍華德.休斯醫學研究所/美國波士頓兒童醫院 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2 EPIGENETICS, CHROMATIN & TRANSCRIPTION 表觀遺傳學、染色質與轉錄 April 23 - 27 461 Participants ORGANIZED BY Rob Martienssen, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 Rui-Ming Xu, Institute of Biophysics, Beijing, China 中國科學院生物物理研究所 Yi Zhang, HHMI/University of North Carolina at Chapel Hill, USA 美國霍華德休斯醫學研究院/美國北卡羅來納大學教堂山分 校 PROGRAM PRE-CONFERENCE WORKSHOP Writing a Paper and Getting it Published: A Brief Guide to Success Philippa Benson, The Charlesworth Group, USA 美國查理斯沃斯集團 John Inglis, Cold Spring Harbor Laboratory Press, USA 美國冷泉港實驗室 EPIGENETIC INHERITANCE AND REPROGRAMMING Yi Zhang, HHMI, University of North Carolina, Chapel Hill, USA DNA METHYLATION: IMPRINTING AND DEVELOPMENT M. Bartolomei, University of Pennsylvania School of Medicine, Philadelphia, USA PLANT EPIGENETICS R. Martienssen, Cold Spring Harbor Laboratory, New York, USA GERM CELL AND REPROGRAMMING K. Helin, University of Copenhagen, Denmark, USA HISTONE MODIFICATIONS AND TRANSCRIPTION A. Shilatifard, Stowers Institute for Medical Research, Kansas City, Missouri, USA FUNCTIONAL EPIGENETICS H.H. Ng, Genome Institute of Singapore, Singapore NON-CODING RNA AND STRUCTURE A. Akhtar, Max-Planck Institut für Immunbiologie,Freiburg, Germany HISTONE VARIANTS AND NUCLEOSOME DYNAMICS R. Xu, Institute of Biophysics, CAS, Beijing, China 3 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia KEYNOTE SPEAKERS Rudolf Jaenisch, Whitehead Institute/MIT, USA 美國麻省理工白頭研究所 Steven Henikoff, Fred Hutchinson Cancer Research Center, USA 美國弗萊德哈欽森癌症研究中心 INVITED SPEAKERS Asifa Akhtar, Max-Planck-Institut fur Immunbiologie, GERMANY 德國馬普免疫生物研究所 Marisa S. Bartolomei, University of Pennsylvania School of Medicine, USA 美國賓夕法尼亞大學醫學院 Ren Bing, Ludwig Institute for Cancer Research, USA 美國路德維希癌症研究所 Sung Hee Baek, Seoul National University, KOREA 韓國首爾大學 Howard Cedar, Hebrew University Hadassah Medical Center, ISRAEL 以色列希伯來大學哈達薩醫學院 Howard Y. Chang, Stanford University, USA 美國斯坦福大學 Don Cleveland, University of California, San Diego, USA 美國加州大學聖地牙哥分校 Xuemei Chen, University of California Riverside, USA 美國加州大學河濱分校 Kristian Helin, University of Copenhagen, Denmark 丹麥哥本哈根大學 Steve Jacobsen, HHMI/University of California, Los Angeles, USA 美國霍華德休斯醫學研究院/美國加州大學洛杉磯分校 Marjori Matzke, Austrian Academy of Sciences, AUSTRIA 奧地利國家科學院 Rob Martienssen, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 Huck-Hui Ng, Genome Institute of Singapore, SINGAPORE 新加坡基因組研究所 Dinshaw J. Patel, Memorial Sloan-Kettering Cance Center, USA 美國紀念斯隆-凱特琳癌症中心 Craig L. Peterson, University of Massachusetts Medical Center, USA 美國麻省大學醫學院 Wolf Reik, The Babraham Institute, UNITED KINGDOM 英國巴布拉漢研究所 Mitinori Saitou, Kyoto University, JAPAN 日本京都大學 Hiroyuki Sasaki, Kyushu University, JAPAN 日本九州大學 Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, SWITZERLAND 瑞士弗雷德里希?蜜雪兒生物醫學研究所 Ali Shilatifard, Stowers Institute for Medical Research, USA 美國密蘇里州斯托瓦斯醫學研究所 Yoichi Shinkai, Institute for Virus Research, Kyoto University, JAPAN 日本京都大學病毒研究所 Davor Solter, A*STAR, SINGAPORE 新加坡科技研究局 X. Sunney Xie, Harvard University, USA 美國哈佛大學 Ruiming Xu, Institute of Biophysics, Beijing, China 中國科學院生物物理研究所 Yi Zhang, HHMI/University of North Carolina at Chapel Hill, USA 美國霍華德休斯醫學研究院/美國北卡羅來納大學教堂山分 校 Keji Zhao, NHLBI, NIH, USA 美國國立衛生研究院 Bing Zhu, National Institute of Biological Sciences, Beijing, China 中國北京生命科學研究所 Jian-Kang Zhu, Purdue University, USA 美國普渡大學 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 4 INFECTIOUS DISEASE GENOMICS AND GLOBAL HEALTH 傳染性疾病基因組學與全球衛生 PARASITES C. Wang, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China PARASITE AND VECTOR R. Gasser, University of Melbourne, Australia VIRUSES B. Andersson, Karolinska Institute, Stockholm, Sweden KEYNOTE SPEAKER George Weinstock, Washington University School of Medicine, USA 美國華盛頓大學醫學院 INVITED SPEAKERS May 7 - 11 62 Participants ORGANIZED BY Julian Parkhill, Wellcome Trust Sanger Institute, UK 英國威康信託基金會桑格研究所 Patrick Tan, Genome Institute of Singapore, Singapore 新加坡基因組研究所 George Weinstock, Washington University School of Medicine, USA 美國華盛頓大學醫學院 Ruifu Yang, Beijing Institute of Microbiology and Epidemiology, China 中國北京微生物學流行病學研究所 Björn Andersson, Karolinska Institute, SWEDEN 瑞典卡羅林斯卡醫學院 Stephen D. Bentley, Wellcome Trust Sanger Institute, UK 英國威康信託基金會桑格研究所 Stephen M. Beverley, Washington University, USA 美國華盛頓大學 Gregory A. Buck, Virginia Commonwealth University, USA 美國維吉尼亞聯邦大學 Swaine L. Chen, Genome Institute of Singapore, SINGAPORE 新加坡基因組研究所 Mariano Garcia-Blanco, Duke University Medical Center, USA 美國杜克大學醫學院 Robin B. Gasser, The University of Melbourne, AUSTRALIA 澳大利亞墨爾本大學 Yi Guan, The University of Hong Kong, China 香港大學 Martin L. Hibberd, Genome Institute of Singapore, SINGAPORE 新加坡基因組研究所 Thewarach Laha, Khon Kaen University, THAILAND 泰國孔敬大學 Raymond J. St. Leger, University of Maryland, USA 美國馬里蘭大學 Stephan Meister, The Scripps Research Institute, USA 美國斯克利普斯研究所 Makedonka Mitreva, Washington University, USA 美國華盛頓大學 Lisa F.P. Ng, Singapore Immunology Network, A*Star, Singapore 新加坡免疫學資訊網, 新加坡科技研究局 Julian Parkhill, Wellcome Trust Sanger Institute, UK 英國威康信託基金會桑格研究所 Gerd J. Pluschke, Swiss Tropical and Public Health Institute, SWITZERLAND 瑞士熱帶和公共健康研究所 Gavin J. Smith, Duke-NUS Graduate Medical School, SINGAPORE 新加坡杜克-新加坡國立大學醫學研究生院 Ruifu Yang, Beijing Institute of Microbiology and Epidemiology, China 中國北京微生物學流行病學研究所 Yajun Song, Beijing Institute of Microbiology and Epidemiology, CHINA 中國北京微生物學流行病學研究所 Patrick Tan, Genome Institute of Singapore, SINGAPORE 新加坡基因組研究所 Chengshu Wang, Shanghai Institutes for Biological Sciences, CAS, CHINA 中國科學院上海生命科學研究院 Jun Wang, Beijing Genomics Institute at Shenzhen, China 深圳華大基因研究院 George Weinstock, Washington University School of Medicine, USA 美國華盛頓大學醫學院 Charlie Xiang, Zhejiang University, China 中國浙江大學 PROGRAM HOST / MICROBE G. Buck, Virginia Commonwealth University, Richmond, Virginia, USA MICROBIOME M. Mitreva, Washington University, St. Louis, Missouri, USA POPULATION GENOMICS R. Yang, Beijing Institute of Microbiology and Epidemiology, Beijing, China BACTERIA M. Antonio, MRC The Gambia Unit, Banjul, The Gambia 5 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 6 LIVER METABOLISM, DISEASES AND CANCER 肝代謝、肝疾病和肝癌症 May 21 - 25 172 Participants ORGANIZED BY Gensheng Feng, University of California, San Diego, USA 美國加州大學 聖地牙哥大學 David Moore, Baylor College of Medicine, USA 美國貝勒醫學院 Hongyang Wang, Eastern Hepatobiliary Surgery Hospital/Institute of Shanghai, China 中國上海東方肝膽外科醫院 PROGRAM BILE ACIDS, NUCLEAR RECEPTORS AND LIVER CANCER D. Moore, Baylor College of Medicine, Houston, Texas, USA C. Liddle, University of Sydney, Sydney, Australia, USA GENETICS, PERIGENETICS AND LIVER DISEASES Y. Yang, NHGRI, National Institutes of Health, Bethesda, Maryland, USA J. Zucman-Rossi, INSERM, Paris, France LIVER CANCER AND CANCER STEM CELLS E. Wagner, Spanish National Cancer Research Center, Madrid, Spain I. Ng, University of Hong Kong, China LIVER DISEASES, CLINICAL AND TRANSLATIONAL MEDICINE A. Miyajima, University of Tokyo, Tokyo, Japan P. Monga, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA KEYNOTE SPEAKERS Michael Karin, University of California, San Diego, USA 美國加州大學聖地牙哥大學 Morris F. White, Children's Hospital Boston/Harvard Medical School, USA 美國波士頓兒 童醫院/哈佛大學醫學院 INVITED SPEAKER David A. Brenner, University of California, San Diego, USA 美國加州大學聖地牙哥大學 Hueng-Sik Choi, Chonnam National University, Korea 韓國全南大學 Jonathan A. Dranoff, University of Arkansas for the Medical Sciences, USA 美國阿肯色 大學醫學院 Gen-Sheng Feng, University of California, San Diego, USA 美國加州大學聖地牙哥大學 Xin-Yuan Fu, National University of Singapore, Singapore 新加坡國立大學 Bin Gao, National Institutes of Health, USA 美國國立衛生研究院 Linda Greenbaum, Thomas Jefferson University, USA 美國湯瑪斯傑弗遜大學 Sanjeev Gupta, Albert Einstein College of Medicine, USA 美國亞伯特愛因斯坦醫學院 Lijian Hui, Shanghai Institute for Biological Sciences, China 中國科學院上海生命科學研究院 Christopher Liddle, University of Sydney, Australia 澳大利亞悉尼大學 Atsushi Miyajima, University of Tokyo, Japan 日本東京大學 Satdarshan Monga, University of Pittsburgh, USA 美國匹茨堡大學 David Moore, Baylor College of Medicine, USA 美國貝勒醫學院 Irene OL Ng, The University of Hong Kong, China 香港大學 Yingzi Yang, National Institutes of Health, USA 美國國立衛生研究院 Erwin F. Wagner, Spanish National Cancer Research Center, Spain 西班牙國立癌症研究中心 Hong-yang Wang, Eastern Hepatobiliary Surgery Hospital/Institute of Shanghai, China 中國上海東方肝膽外科醫院 Xin Wei Wang, National Institute of Health, USA 美國國立衛生研究院 Jessica Zucman-Rossi, INSERM, France 法國國家衛生研究院 LIVER DEVELOPMENT, STEM CELLS AND CANCER L. Greenbaum, Thomas Jefferson University, Philadelphia, Pennsylvania, USA B. Gao, NIAAA, National Institutes of Health, Bethesda, Maryland, USA LIVER INJURY, FIBROSIS AND CIRRHOSIS D. Brenner, University of California-San Diego, La Jolla, California, USA J. Dranoff, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA Workshop on PUBLICATIONS IN HIGH-IMPACT JOURNALS Xiaohong (Helena) Yang, Cancer Cell, Cell Press, USA 美國CELL出版社 Randy Levinson, Nature Medicine, USA 美國NATURE出版社 Myles Axton, Nature Genetics, USA 美國NATURE出版社 7 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 8 BONE AND CARTILAGE: FROM DEVELOPMENT TO HUMAN DISEASES 骨骼與軟骨:從發育學到人類疾病 THERAPEUTIC APPROACHES FOR SKELETAL DISEASES H. Kawaguchi, University of Tokyo, Japan KEYNOTE SPEAKERS Bjorn Olsen, Harvard Medical School, USA 美國哈佛大學醫學院 Henry M. Kronenberg, Massachusetts General Hospital & Harvard Medical School, USA 美國哈佛大學醫學院,麻省總醫院 Stefan Lohmander, Lund University Sweden/University of Southern Denmark, Sweden 瑞典隆德大學/南丹麥大學 Bjorn R. Olsen, Harvard Medical School, USA 美國哈佛大學醫學院 INVITED SPEAKERS June 11 - 15 131 Participants ORGANIZED BY Christine Hartmann, University of Münster, Germany德國明斯特大學 Hiroshi Kawaguchi, University of Tokyo, Japan日本東京大學 Dae-Won Kim, Yonsei University, South Korea 韓國延世大學 Fanxin Long, Washington University School of Medicine, USA 美國華盛頓大學醫學院 PROGRAM CARTILAGE DEVELOPMENT D.-W. Kim, Yonsei University, Seoul, South Korea GENETICS / EPIGENETICS FOR HUMAN SKELETAL DISEASE F. Long, Washington University in St. Louis, Missouri, USA OSTEOCLAST DEVELOPMENT C. Hartmann, Research Institute for Molecular Pathology, Vienna, Austria OSTEOSCLEROSIS, OSTEOPETROSIS AND OSTEOPOROSIS C. Hartmann, Research Institute for Molecular Pathology, Vienna, Austria Benjamin A. Alman, University of Toronto/The Hospital for Sick Children, CANADA 加 拿大多倫多大學/加拿大多倫多兒童醫院 Frank Beier, University of Western Ontario, CANADA 加拿大西安大略大學 Xu Cao, Johns Hopkins University, School of Medicine, USA 美國約翰霍普斯金大學醫 學院 Kathryn S. Cheah, University of Hong Kong, CHINA 香港大學 Christine Hartmann, University of Münster, Germany 德國明斯特大學 Matthew J. Hilton, University of Rochester Medical Center, USA 美國羅切斯特大學醫 學中心 Wim Van Hul, University of Antwerp (UIA), BELGIUM 比利時布魯塞爾天主教大學 Masaru Ishii, Osaka University, JAPAN 日本大阪大學 Hiroshi Kawaguchi, University of Tokyo, JAPAN 日本京東大學 Dae-Won Kim, Yonsei University, South Korea 韓國延世大學 Andrew B. Lassar, Harvard Medical School, USA 美國哈佛大學醫學院 Brendan Lee, Baylor College of Medicine/HHMI, USA 美國貝勒醫學院/霍華德休斯醫學研究所 Eryuan Liao, Second Xiangya Hospital of Central South University, China 中國中南大學湘雅二醫院 Veronique Lefebvre, Cleveland Clinic Lerner Research Institute, USA 美國克利夫蘭醫學中心 Fanxin Long, Washington University School of Medicine, USA 美國華盛頓大學醫學院 David M. Ornitz, Washington University School of Medicine, USA 美國華盛頓大學醫學院 Vicki Rosen, Harvard School of Dental Medicine, USA 美國哈佛大學牙醫學院 Gary S. Stein, University of Massachusetts Medical School, USA 美國麻州大學醫學院 Hiroshi Takayanagi, Tokyo Medical and Dental University, JAPAN 東京醫科齒科大學 Noriyuki Tsumaki, Kyoto University, JAPAN 日本京都大學 Yihong Wan, UT Southwestern Medical Center, USA 美國德州大學西南醫學中心 Matthew Warman, Harvard Medical School/Children's Hospital Boston, USA 美國哈佛大學醫學院/美國波士頓兒童醫院 Michael P. Whyte, Washington University School of Medicine/Shriners Hospital for Children, USA 美國華盛頓醫學院/ Shriners兒 童醫院 Yingzi Yang, National Institutes of Health, USA 美國國立衛生研究院 Elazar Zelzer, Weizmann Institute of Science, ISRAEL 以色列威茨曼研究院 OSTEOBLAST DEVELOPMENT F. Long, Washington University in St. Louis, Missouri, USA HOMEOSTASIS IN SKELETAL TISSUES D.-W. Kim, Yonsei University, Seoul, South Korea CARTILAGE DEGENERATION AND OSTEOARTHRITIS H. Kawaguchi, University of Tokyo, Japan 9 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 10 INVERTEBRATE NEUROBIOLOGY 無脊椎動物神經生物學 NEURAL DEVELOPMENT II F. Yu, Temasek Life Science Laboratory, Singapore A. Ejima, Kyoto University, Japan SENSORY AND MOTOR SYSTEMS II T. Lee, HHMI Janelia Farm Research Campus, Ashburn, Virginia, USA A.Keene, University of Nevada, Reno, USA KEYNOTE SPEAKER Martin Chalfie, Columbia University, USA 美國哥倫比亞大學 Nicholas J. Strausfeld, University of Arizona, USA 美國亞利桑那大學 INVITED SPEAKERS June 18 - 22 83 Participants ORGANIZED BY Aike Guo, Institute of Neuroscience, CAS, China 中國科學院神經科學研究所 Alison Mercer, University of Otago, New Zealand 新西蘭奧塔哥大學 Ikue Mori, Nagoya University, Japan 日本名古屋大學 Bing Zhang, University of Oklahoma, USA 美國奧克拉荷馬大學 PROGRAM NEURAL DEVELOPMENT I Mario de Bono, MRC Laboratory of Molecular Biology, UNITED KINGDOM 英國 醫學研究委員會分子生物實驗室 Ann-Shyn Chiang, National Tsing Hua University, Taiwan 臺灣國立清華大學 Aki Ejima, Kyoto University, JAPAN 日本京都大學 David L. Glanzman, University of California, Los Angeles, USA 美國加州大學洛杉 磯分校 Martin Giurfa, University Paul-Sabatier, FRANCE 法國圖盧茲第三大學 Zhefeng Gong, Zhejiang University, CHINA 中國浙江大學 Binyamin Hochner, Hebrew University, ISRAEL 以色列耶路撒冷希伯來大學 Ryohei Kanzaki, University of Tokyo, JAPAN 日本東京大學 Christoph J. Kleineidam, University of Konstanz, GERMANY 德國康斯坦茲大學 Li Liu, Institute of Biophysics, CAS 中國科學院生物物理研究所 Fernando Montealegre-Z, Bristol University, UK 英國布裏斯托大學 Alison R. Mercer, University of Otago, New Zealand 新西蘭奧塔哥大學 Ron Harris-Warrick, Cornell University, USA 美國康奈爾大學 Tzumin Lee, HHMI, Janelia Farm Research Campus, USA 霍華德休斯醫學研究所Janelia Farm研究院 Karen A. Mesce, University of Minnesota, USA 美國明尼蘇達大學 Ikue Mori, Nagoya University, Japan 日本名古屋大學 Bruno van Swinderen, University of Queensland, AUSTRALIA 澳大利亞昆士蘭大學 Daisuke Yamamoto, Tohoku University, JAPAN 日本東北大學 Fengwei Yu, Temasek Life Sciences Laboratory, Singapore 新加坡淡馬錫生命科學實驗室 Bing Zhang, University of Oklahoma, USA 美國奧克拉荷馬大學 H. Wang, Duke-NUS Graduate Medical School Singapore, Singapore B. van Swinderen, University of Queensland, Brisbane, Australia SENSORY AND MOTOR SYSTEMS I A. Ayali, Tel Aviv University, Israel Y. Jin, HHMI, University of California, San Diego, USA NEURAL CIRCUITS AND BEHAVIORS K. Mesce, University of Minnesota, St. Paul, USA L. Liu, Institute of Biophysics, CAS, Beijing, China LEARNING AND MEMORY R. Harris-Warrick, Cornell University, Ithaca, New York, USA I. Mori, Nagoya University, Japan 11 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 12 FRONTIERS OF IMMUNOLOGY IN HEALTH AND DISEASES 健康與疾病中的免疫學前沿研究 September 3 - 7 241 Participants ORGANIZED BY Xuetao Cao, Chinese Academy of Medical Sciences, CHINA 中國醫學科學院 Richard Flavell, HHMI, Yale University School of Medicine, USA 美國霍華德.休斯醫學研 究所/耶魯大學醫學院 Tadatsugu Taniguchi, University of Tokyo Institute of Industrial Science, JAPAN 日本東京大 學生產技術研究所 PROGRAM INNATE IMMUNE RESPONSE AND INFLAMMATION I J. Ting, University of North Carolina, Chapel Hill, USA INNATE IMMUNE RESPONSE AND INFLAMMATION II T. Taniguchi, University of Tokyo Institute of Industrial Science, Japan DEVELOPMENT AND FUNCTION OF THE ADAPTIVE IMMUNE SYSTEM W. Yokoyama, HHMI, Washington University, St. Louis, Missouri, USA MUCOSAL IMMUNITY A. Iwasaki, Yale University School of Medicine, New Haven, Connecticut, USA IMMUNE REGULATION AND TOLERANCE I INVITED SPEAKERS Xuetao Cao, Chinese Academy of Medical Sciences, CHINA 中國醫學科學院 Vincenzo Cerundolo, University of Oxford, UK 英國牛津大學 Genhong Cheng, University of California Los Angeles, USA 美國加州大學洛杉磯分校 Chen Dong, MD Anderson Cancer Center, USA 美國安德森癌症研究中心 Richard A. Flavell, HHMI, Yale University School of Medicine, USA 美國霍華德.休斯醫學研究所/耶魯大學醫學院 Xin-Yuan Fu, National University of Singapore, SINGAPORE 新加坡國立大學 Frederic Geissmann, King's College London, UK 英國倫敦國王學院 Kenya Honda, University of Tokyo, JAPAN 日本東京大學 Yu-Lung Lau, University of Hong Kong, CHINA 香港大學 Akiko Iwasaki, Yale University School of Medicine, USA 美國耶魯大學醫學院 Shigeo Koyasu, Keio University School of Medicine, JAPAN 日本慶應義塾大學醫學部 Juan J. Lafaille, New York University, USA 美國紐約大學 Yong-Jun Liu, Baylor Institute for Immunology Research, USA 美國貝勒免疫研究所 Robert D. Schreiber, Washington University, USA 美國華盛頓大學 Bing Sun, Shanghai Institutes for Biological Sciences, CAS, CHINA 中國科學院上海生命科學研究院 Tadatsugu Taniguchi, University of Tokyo Institute of Industrial Science, JAPAN 日本東京大學生產技術研究所 Zhigang Tian, University of Science & Technology of China, CHINA 中國科學技術大學 Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA 美國北卡羅來納州大學教堂山分校 Emil R. Unanue, Washington University School of Medicine, USA 美國華盛頓大學醫學院 Jose A. Villadangos, The University of Melbourne, AUSTRALIA 澳大利亞墨爾本大學 Li Wu, Walter & Eliza Hall Institute, AUSTRALIA 澳大利亞沃爾特和伊麗莎豪醫學研究所 Wayne M. Yokoyama, HHMI/Washington University, USA 美國霍華德.休斯醫學研究所/美國華盛頓大學 Jingwu Zang, GlaxoSmithKline, China 葛蘭素史克中國公司 Yu Zhang, Peking University Health Center, China 北京大學醫學部 Moncef Zouali, Inserm & University Paris Diderot, Sorbone Paris Cité, FRANCE 法國國家衛生研究院,巴黎狄德羅大學 E. Unanue, Washington University School of Medicine, St. Louis, Missouri, USA IMMUNE REGULATION AND TOLERANCE II R. Flavell, Yale University School of Medicine, New Haven, Connecticut, USA AUTOIMMUNITY AND ALLERGY M. Zouali, INSERM, University Paris Diderot, France KEYNOTE SPEAKER Ruslan Medzhitov, HHMI / Yale University School of Medicine, USA 美國霍華德.休斯醫 學研究所/耶魯大學醫學院 13 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 14 ION CHANNELS: BIOPHYSICS, DISEASES AND THERAPEUTICS 離子通道:生物物理學、疾病與治療 KEYNOTE SPEAKER Lily Jan, University of California, San Francisco, USA 美國加州大學三藩市分校 Yuh-Nung Jan, University of California, San Francisco/HHMI, USA 美國加州大學三藩市分校/霍華德.休斯醫學研究所 Henry A. Lester, California Institute of Technology, USA 美國加利福尼亞理工學院 INVITED SPEAKERS September 17 - 21 114 Participants ORGANIZED BY Hualiang Jiang, Shanghai Institute of Materia Medica, China 中國科學院上海藥物研究 所 Henry Lester, California Institute of Technology, USA 美國加利福尼亞理工學院 Min Li, Johns Hopkins University School of Medicine, USA 美國約翰霍普金斯大學醫學院 Jianpeng Ma, Baylor College of Medicine, USA 美國貝勒醫學院 PROGRAM ION CHANNEL BIOPHYSICS J. Ma, Baylor College of Medicine, Houston, Texas, USA N. Yan, Tsinghua University, Beijing, China ION CHANNELS: PHARMACOLOGY, TRAFFICKING AND POST-TRANSLATIONAL REGULATION W. Balch, Scripps Research Institute, La Jolla, California, USA H. Zhang, Hebei Medical University, Shijiazhuang, China Katriina Aalto-Setälä, University of Tampere, FINLAND 芬蘭坦佩雷大學 William E. Balch, The Scripps Research Institute, USA 美國斯克利普斯研究所 Donald M. Engelman, Yale University, USA 美國耶魯大學 Lior Gepstein, Technion-Israel Institute of Technology, ISRAEL 以色列理工大學 Yong-Hua Ji, Shanghai University, CHINA 中國上海大學 Hualiang Jiang, Shanghai Institute of Materia Medica, China 中國科學院上海藥物研究所 Gregory J. Kaczorowski, Kanalis Consulting, LLC, USA 美國Kanalis諮詢有限公司 Min Li, Johns Hopkins University School of Medicine, USA 美國約翰霍普金斯大學醫學院 Jianpeng Ma, Baylor College of Medicine, USA 美國貝勒醫學院 Erik Renström, Lund University, SWEDEN 瑞典蘭德大學 Eitan Reuveny, Weizmann Institute of Science, ISRAEL 以色列魏茨曼科學研究所 Gail A. Robertson, University of Wisconsin-Madison, USA 美國威斯康星大學 Chikara Sato, National Institute of Advanced Industrial Science and Technology, JAPAN 日本產業技術總合研究所 KeWei Wang, Peking University, China 中國北京大學 Theodore G. Wensel, Baylor College of Medicine, USA 美國貝勒醫學院 Gregory A. Voth, The University of Chicago, USA 美國芝加哥大學 Nieng Yan, Tsinghua University, China 中國清華大學 Hailin Zhang, Hebei Medical University, CHINA 中國河北醫科大學 Ming Zhou, Baylor College of Medicine, USA 美國貝勒醫學院 Zhuan Zhou, Pekin University, CHINA 中國北京大學 Michael X. Zhu, CAS/The Univ. of Texas Health Science Center at Houston, China/USA 中國科學院/美國德克薩斯大學休斯頓 健康科學中心 DRUG DISCOVERY: FROM TOOLS TO THERAPEUTICS M. Li, Johs Hopkins Ion Channel Center, Baltimore, Maryland, USA G. Kaczorowski, Merck and Kanalis Consulting, Edison, New Jersey, USA CHANNELOPATHIES: DISEASES, GENETICS AND BEYOND I E. Renström, Lund University, Malmö, Sweden K. Wang, Peking University School of Pharmaceutical Sciences, Beijing, China CHANNELOPATHIES: DISEASES, GENETICS AND BEYOND II E. Renström, Lund University, Malmö, Sweden K. Wang, Peking University School of Pharmaceutical Sciences, Beijing, China SIGNAL SENSING AND CODING M. Shapiro, University of Texas Health Science Center, San Antonio, Texas, USA M. Zhu, SIMM, Chinese Academy of Science, Shanghai, China; University of Texas Health Science Center, Houston, Texas, USA STEM CELLS, iPSCs AND DISEASE MODELS K. Aalto-Setälä, University of Tampere, Finland L. Gepstein, Technion-Israel Insitute of Technology, Haifa, Israel 15 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 16 SMALL GTPASES AT DIFFERENT SCALES: PROTEINS, MEMBRANES, CELLS 小GTP酶: 蛋白質、膜、細胞 RAB: PROTEINS, MEMBRANES, CELLS K. Aktories, University of Freiburg, Freiburg, Germany RAB AND OTHER GTPases D. Lambright, University of Massachusetts Medical School, Worcester, Massachusetts, USA SIMULATIONS AND OTHER GT K. Gerwert, Ruhr-University Bochum / CAS-Max-Planck-Institute, PICB, Shanghai, China INVITED SPEAKERS September 24 - 28 123 Participants ORGANIZED BY Jianping Ding, Shanghai Institutes for Biological Sciences, CAS, China 中國科學院上海生命科學研究院 Klaus Gerwert, Ruhr-University Bochum, Germany/PICB, CAS, China 德國波鴻魯爾大學/中科院-馬普學會計計算生物學夥伴 研究所 Roger Goody, Max Planck Institute, Germany 德國馬克斯?普朗克研究所 Shuh Narumiya, Kyoto University, Japan 日本京都大學 PROGRAM RAS: FROM PROTEIN TO MEMBRANE I J. Ding, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China Klaus Aktories, University of Freiburg, GERMANY 德國弗萊堡大學 Xiao-Wei Chen, University of Michigan, USA 美國密歇根大學 Channing J. Der, University of North Carolina at Chapel Hill, USA 美國北卡羅來納州大學教堂山分校 Jianping Ding, Shanghai Institutes for Biological Sciences,CAS, China 中國科學院上海生命科學研究院 Mitsunori Fukuda, Tohoku University, Graduate School fo Life Sciences, Japan 日本東北大學生命科學院 Klaus Gerwert, Ruhr-University Bochum, Germany/PICB, CAS, China 德國波鴻魯爾大學/中科院-馬普學會計計算生物學夥伴 研究所 Alemayehu A. Gorfe, University of Texas Medical School - Houston, USA 美國德克薩斯大學休士頓健康科學中心 Andrew B. Goryachev, University of Edinburgh, Center for Systems Biology, United Kingdom 英國愛丁堡大學系統生物學中心 Roger S. Goody, Max Planck Institute, GERMANY 德國馬克斯.普朗克研究所 John F. Hancock, University of Texas, USA 美國德克薩斯大學 Christian Herrmann, Ruhr-University Bochum, GERMANY 德國波鴻魯爾大學 Toshimasa Ishizaki, Kyoto University, JAPAN 日本京都大學 Hans Robert Kalbitzer, University of Regensburg, GERMANY 德國雷根斯堡大學 Yoel Kloog, Tel Aviv University ISRAEL 以色列特拉維夫大學 David Lambright, University of Massachusetts Medical School, USA 美國麻省醫學院 Fang-Jen S. Lee, National Taiwan University, TAIWAN 國立臺灣大學 Zhen-Ge Luo, Shanghai Institute of Neuroscience, SIBS, CAS, CHINA 中國科學院神經科學研究所 Edward Manser, Institute of Medical Biology, sGSK Group, SINGAPORE 新加坡醫學生物學研究所,sGSK組 Didier A. Marguet, INSERM-CNRS de Marseille-Luminy, FRANCE 法國國家衛生研究院 Shuh Narumiya, Kyoto University, JAPAN 日本京都大學 Alexander Nemukhin, M.V.Lomonosov Moscow State University, RUSSIA 俄羅斯莫斯科國立羅蒙諾索夫大學 Mark R. Philips, New York University Cancer Insitute, USA 美國紐約大學癌症研究所 Xiaochen Wang, National Institute of Biological Sciences, CHINA 中國北京生命科學研究所 Arieh Warshel, University of Southern California, USA 美國南加州大學 Roland Winter, TU Dortmund, GERMANY 德國多特蒙德工業大學 Michael White, UT Southwestern Medical Center, USA 美國德克薩斯大學西南醫學中心 Yanhui Xu, Fudan University, China 中國復旦大學 Xuewu Zhang, University of Texas Southwestern Medical Center, USA 美國德克薩斯大學西南醫學中心 RAS: FROM PROTEIN TO MEMBRANE II K. Gerwert, Ruhr-University Bochum / CAS-Max-Planck-Institute, PICB, Shanghai, China RAS: INTRACELLULAR PROCESSES S. Narumiya, Kyoto University, Kyoto, Japan RHO: PROTEINS, MEMBRANES, CELLS I R. Goody, Max Planck Institute, Dortmund, Germany RHO: PROTEINS, MEMBRANES, CELLS II M. Fukuda, Tohoku University, Miyagi, Japan 17 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 18 RNA BIOLOGY RNA生物學 KEYNOTE SPEAKER Gregory Hannon, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 INVITED SPEAKERS October 8 - 12 219 Participants ORGANIZED BY Fátima Gebauer, Centre de Regulació Genómica, SPAIN 西班牙基因調控中心 Narry Kim, Seoul National University, KOREA 韓國首爾大學 Adrian Krainer, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 Mutsuhito Ohno, Kyoto University, JAPAN 日本京都大學 PROGRAM NON-CODING RNA: MECHANISM Y. Tomari, University of Tokyo, Tokyo, Japan TRANSLATIONAL CONTROL D. Ruggero, University of California, San Francisco, California, USA RIBOSOMES, RNA MODIFICATIONS AND FOLDING U. Kutay, Swiss Federal Institute of Technology, Zurich, Switzerland NON-CODING RNAs IN DEVELOPMENT AND DISEASE Maria Barna, University of California, San Francisco, USA 美國加州大學三藩市分校 Douglas L. Black, HHMI/University of California, Los Angeles, USA 美國霍華德.休斯醫學研究所/美國加州大學洛杉磯分校 Alfredo Castello, European Molecular Biology Laboratory, GERMANY 歐洲分子生物學實驗室 Stephen M. Cohen, A*STAR, SINGAPORE 新加坡科技研究局 Paul L. Fox, Cleveland Clinic, USA 美國克裏夫蘭臨床醫學中心 Xiang-Dong Fu, University of California, San Diego, USA 美國加利福尼亞大學聖地牙哥分校 Fátima Gebauer, Centre de Regulació Genómica, SPAIN 西班牙基因調控中心 Sunjoo Jeong, Dankook University, Korea 韓國檀國大學 Adrian R. Krainer, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 Narry Kim, Seoul National University, KOREA 韓國首爾大學 Yoon Ki Kim, Korea University, KOREA 韓國高麗大學 Mofang Liu, Institute of Biochemistry and Cell Biology, SIBS, CHINA 中國科學院上海生命科學研究院生物化學與細胞生物學研 究所 Mutsuhito Ohno, Kyoto University, JAPAN 日本京都大學 John L. Rinn, Broad Institute of MIT/Harvard Medical School, USA 美國麻省理工/美國哈佛大學醫學院 Davide Ruggero, University of California, San Francisco, USA 美國加州大學三藩市分校 Tsutomu Suzuki, University of Tokyo, JAPAN 日本東京大學 Woan-Yuh Tarn, Academia Sinica, Taiwan 臺灣中央研究院 Yukihide Tomari, University of Tokyo, JAPAN 日本東京大學 Rui-Ming Xu, Institute of Biophysics, CAS, CHINA 中國科學院生物物理研究所 Chaolin Zhang, The Rockefeller University, USA 美國洛克菲勒大學 Zhi-Ming Zheng, The National Cancer Institute, USA 美國國家癌症研究所 S. Cohen, A*STAR, Singapore SPLICING MECHANISMS, REGULATION AND DISEASE W.-Y. Tarn, Academia Sinica, Taipei, Taiwan mRNA FACTORY X.-D. Fu, University of California, San Diego, California, USA RNA-BINDING PROTEINS S. Jeong, Dankook University, Yongin, South Korea 19 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 20 HIGH THROUGHPUT BIOLOGY - GENOMICS & EPIGENOMICS 高通量生物學- 基因組學與表觀基因組學 NEW FRONTIERS B. Ren, Ludwig Institute for Cancer Research, University of California, San Diego, USA KEYNOTE SPEAKER Lucy Shapiro, Stanford University, USA 美國斯坦福大學 INVITED SPEAKERS October 15 - 19 151 Participants ORGANIZED BY Edward Rubin, Lawrence Berkeley National Laboratory and DOE Joint Genome Institute, USA 美國勞倫斯伯克力國家實驗室, 美國能源部聯合基因研究所 Bing Ren, Ludwig Institute for Cancer Research, UCSD, USA 美國加州大學聖地牙哥分校路德維格癌症研究所 Tian Xu, HHMI, Yale University and Fudan University, USA/China 美國霍華德休斯醫學研究院,耶魯大學,中國復旦大學 PROGRAM HIGH THROUGHPUT GENETICS T. Xu, Yale University, New Haven, Connecticut, USA /Fudan University, Shanghai, China EPIGENOMIC ANALYSIS OF ANIMAL CELLS J. Stamatoyannopoulos, University of Washington, Seattle, USA HIGHER ORDER ORGANIZATION OF GENOME Brenda J. Andrews, University of Toronto, CANADA 加拿大多倫多大學 Jan E. Carette, Stanford University, USA 美國斯坦福大學 Piero Carninci, RIKEN, JAPAN 日本理化學研究所 Job Dekker, University of Massachusetts Medical School, USA 美國麻省大學醫學院 Rong Fan, Yale University, USA 美國耶魯大學 Xiang-Dong Fu, University of California, San Diego, USA 美國加州大學聖地牙哥分 校 Melissa J. Fullwood, A*STAR-Duke-NUS, SINGAPORE 新加坡科技研究局/杜克大學 -新加坡國立大學 Jian-Dong Huang, The University of Hong Kong, Hong Kong CHINA 香港大學 Jihyun F. Kim, Yonsei University, KOREA 韓國延世大學 Jin Billy Li, Stanford University School of Medicine, USA 美國斯坦福大學醫學院 Jinsong Li, SIBS, CAS, CHINA 中國科學院上海生命科學研究院 Jason D. Lieb, University of North Carolina, USA 美國北卡羅來納州大學 Harley McAdams, Stanford University School of Medicine, USA 美國斯坦福大學醫學院 Bing Ren, Ludwig Institute for Cancer Research, UCSD, USA 美國加州大學聖地牙哥分校路德維希癌症研究所 X. Sunney Xie, Harvard University, USA 美國哈佛大學 Tian Xu, HHMI, Yale University/Fudan University, USA/China 美國霍華德休斯醫學研究院,耶魯大學,中國復旦大學 Heng Zhu, John Hopkins University, USA 美國約翰霍普金斯大學 Yong Hou, Beijing Genome Institute - Shenzhen, CHINA 中國深圳華大基因研究院 Fuchou Tang, Peking University, CHINA 中國北京大學 Robin Gasser, University of Melbourne, AUSTRALIA 澳大利亞墨爾本大學 Eddy Rubin Lawrence Berkeley National Laboratory and DOE Joint Genome Institute 美國勞倫斯伯克力國家實驗室, 美國能源 部聯合基因研究所 Renfu Shao, University of the Sunshine Coast, AUSTRALIA 澳大利亞陽光海岸大學 A.J. Marian Walhout, UMass Medical School, USA 美國麻省大學醫學院 Jussi Taipale, Karolinska Institute, SWEDEN 瑞典卡羅林斯卡學院 Kun Zhang, University of California, San Diego, USA 美國加州大學聖地牙哥分校 Ming-Ming Zhou, Mount Sinai School of Medicine, USA 美國西奈山醫學院 J. Dekker, University of Massachusetts Medical School, Worcester, USA SINGLE CELLS GENOMICS K. Zhang, University of California,San Diego, USA HARNESSING HIGH THROUGHPUT TECHNOLOGIES TO TACKLE NEGLECTED PARASITIC DISEASES OF MAJOR SOCIOECONOMIC IMPORTANCE R. Shao, University of the Sunshine Coast, Australia R. Gasser, University of Melbourne, Australia GENE REGULATORY NETWORKS M. Walhout, University of Massachusetts Medical School, Worcester, USA TRANSCRIPTOME ANALYSIS E. Rubin, Lawrence Berkeley National Laboratory and DOE Joint Genome Institute, California, USA 21 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 22 DIFFERENTIATION THERAPY AND ADVANCES IN CANCER 腫瘤的轉化治療與進展 October 20-24 156 Participants ORGANIZED BY Zhu Chen, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China 中國上海交通大學醫學院附屬瑞金醫院/中國上海血液 學研究所 Saijuan Chen, Shanghai Institute of Hematology,Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China 中國上海交通大學醫學院附屬瑞金醫院/中國上海 血液學研究所 Samuel Waxman, The Mount Sinai Medical Center, USA 美國紐約西奈山醫療中心 PROGRAM EPIGENETICS AND EPIGENOMICS: MECHANISM AND IMPACT ON CANCER THERAPY S. Chen, Shanghai Jiaotong University, Shanghai, China M. Rosenfeld, HHMI/University of California,-San Diego, La Jolla, California, USA CANCER STEM CELLS AND NOVEL TARGETS J. Zhu, Shanghai Jiao-tong University, Shanghai, China B. Neel, Ontario Cancer Institute, Toronto, Canada GENETICS AND GENOMICS OF CANCER Y. Zeng, Peking Union Medical College, Beijing, China D. Tenen, Cancer Science Institute of Singapore, NUS, Singapore CANCER MODELS J. Wang, Beijing Genomics Institute at Shenzhen, China R. Dalla-Favera, Columbia University, New York, USA TARGETED THERAPIES: PRESENT AND FUTURE Q. Zhan, Peking Union Meidcal College, Beijing, China L. Gudas, Weill Cornell Medical College, New York, USA KEYNOTE SPEAKERS Stephen B. Baylin, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 美國約翰霍普金斯 大學西德尼-凱莫綜合癌症中心 Zhu Chen, Shanghai Institute of Hematology, Shanghai, China 中國上海交通大學醫學院附屬瑞金醫院/中國上海血液學研究所 Carlo M. Croce, The Ohio State University Medical Center, USA 美國俄亥俄州立大學 Samuel Waxman, Mount Sinai School of Medicine, New York, USA 美國紐約西奈山醫療中心 INVITED SPEAKERS Saijuan Chen, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China 中國上海交通大學醫學院附屬瑞金醫院,上海血液學研究所 John D. Crispino, Northwestern University, USA 美國西北大學 Riccardo Dalla-Favera, Columbia University, USA 美國哥倫比亞大學 Tariq Enver, UCL Cancer Institute, UNITED KINGDOM 英國倫敦大學癌症研究所 Lorraine J. Gudas, Weill Cornell Medical College, USA 美國威爾康乃爾醫學院 Ze-Guang Han, Shanghai Jiaotong University, China 中國上海交通大學 Gunther Hartmann, Universitätsklinikum Bonn, GERMANY 德國波恩大學 Scott W. Hiebert, Vanderbilt University, USA 美國范德堡大學 Shai Izraeli, Sheba Medical Center, ISRAEL 以色列夏巴醫學中心 H. Phillip Koeffler, Cancer Science Institute of Singapore, NUS 新加坡國立大學 Quentin Liu, Cancer Center of SYSU, China 中國山大學腫瘤防治中心 Xin Lu, Ludwig Institute for Cancer Research Ltd, UK 英國路德維格腫瘤研究所 Ari Melnick, Weill Cornell Medical College, USA 美國威爾康乃爾醫學院 Benjamin G. Neel, Ontario Cancer Institute/MaRs Centre, CANADA 加拿大安大略省癌症研究中心 Tomoki Naoe, Nagoya University Graduate School of Medicine, JAPAN 日本名古屋大學醫學研究院 Ryuzo Ohno, Aichi Cancer Center Hospital, JAPAN 日本愛知縣癌症中心醫院 Yang Shi, Harvard Medical School, USA 美國哈佛醫學院 Martin S. Tallman, Memorial Sloan-Kettering Cancer Center, USA 美國紀念斯隆-凱特琳癌症中心 Daniel G. Tenen, Cancer Science Institute of Singapore, NUS, Singapore 新加坡國立大學癌症科學研究所 Hugues de Thé, Université Paris 7/CNRS, France 法國巴黎第七大學 Jun Wang, BGI-Shenzhen, China 中國深圳華大基因研究院 Yue Xiong, University of North Carolina at Chapel Hill, USA 美國北卡羅來納州大學教堂山分校 Qimin Zhan, Peking Union Meidcal College, China 中國北京協和醫學院 Ming-Ming Zhou, Mount Sinai School of Medicine, USA 美國西奈山醫學院 WORKSHOP: NOVEL TARGETS AND STRATEGIES Stephen Baylin, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, USA 美國約翰霍普金斯大學西德尼-凱莫綜合癌症中心 DIFFERENTIATION THERAPY OF APL AND BEYOND S. Waxman, Mount Sinai Medical Center, New York, USA J. Zhang, Shanghai Jiaotong University, Shanghai, China 23 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 24 PLANT EPIGENETICS, STRESS AND EVOLUTION 植物表觀遺傳學、環境壓力和進化 EPIGENETICS AND EVOLUTION J. Paszkowski, University of Geneva, Geneva, Switzerland MECHANISMS AND EFFECTS R. Martienssen, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA KEYNOTE SPEAKERS Caroline Dean, John Innes Centre, United Kingdom 英國約翰英尼斯中心 Marjori Matzke, Austrian Academy of Sciences, AUSTRIA 奧地利國家科學院 Robert A. Martienssen, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 INVITED SPEAKERS October 29 – November 2 185Participants ORGANIZED BY Jian-Kang Zhu, Purdue University and Shanghai Center for Plant Stress Biology, USA and China 美國普渡大學/ 海植物逆境生物學研究中心 Yijun Qi, National Institute of Biological Sciences, Beijing, China 中國北京生命科學研究所 Brandon Gaut, University of California, Irvine, USA 美國加州大學歐文分校 Zhizhong Gong, China Agricultural University, China 中國農業大學 PROGRAM DNA METHYLATION AND GENE SILENCING M. Matzke, Austrian Academy of Sciences, Vienna, Austria 中國科學院上 M. Kathryn Barton, Carnegie Institution, USA 美國卡耐基研究所 Xiaofeng Cao, Institute of Genetics & Developmental Biology, CAS, China 中國科學院遺傳與發育生物學研究所 Juliette de Meaux, University of Münster, GERMANY 德國明斯特大學 Shou-Wei Ding, University of California, Riverside, USA 美國加州大學河濱分校 Brandon S. Gaut, University of California, Irvine, USA 美國加州大學歐文分校 Zhizhong Gong, China Agricultural University, CHINA 中國農業大學 Xin-Jian He, National Institute of Biological Sciences, Beijing, CHINA 中國北京生命科學研究所 Lena C. Hileman, The University of Kansas, USA 美國堪薩斯大學 Hailing Jin, University of California Riverside, USA 美國加州大學河濱分校 Tetsuji Kakutani, National Institute of Genetics, JAPAN 日本國立遺伝學研究所 Damon R. Lisch, University of California, Berkeley, USA 美國加利福尼亞大學伯克利分校 Ortrun Mittelsten Scheid, Gregor Mendel Institute of Molecular Plant Biology, AUSTRIA 奧地利格雷戈爾?孟德爾植物分子生物 學研究所 Magnus Nordborg, Gregor Mendel Institute, AUSTRIA 奧地利孟德爾研究所 Jerzy Paszkowski, University of Geneva, SWITZERLAND 瑞士日內瓦大學 Yijun Qi, National Institute of Biological Sciences, Beijing, China 中國北京生命科學研究所 Weiqiang Qian, Shanghai Center for Plant Stress Biology, CAS, CHINA 中國科學院上海植物逆境生物學研究中心 Eric J. Richards, Cornell University, USA 美國康奈爾大學 Herve Vaucheret, Institut Jean-Pierre Bourgin, France 法國農業科學研究院 Olivier Voinnet, Institut de Biologie Moleculaire des Plantes, FRANCE 法國植物分子生物學研究所 Daniel Zilberman, University of California, Berkeley, USA美國加利福尼亞大學伯克利分校 HISTONE MODIFICATIONS AND GENE SILENCING Y. Qi, National Institute of Biological Sciences, Beijing, China NON-CODING RNAs AND GENE SILENCING H. Jin, University of California, Riverside, California, USA EPIALLELES AND EPIGENETIC VARIATION B. Gaut, University of California, Irvine, California, USA STRESS AND EPIGENETICS Z. Gong, China Agricultural University, Beijing, China 25 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 26 NEURAL CIRCUIT BASIS OF BEHAVIOR AND ITS DISORDERS 行為及行為障礙的神經回路基礎原理 November 5 - 9 144 Participants ORGANIZED BY Guoping Feng, Massachusetts Institute of Technology, USA 美國麻省理工學院 Yasunori Hayashi, Brain Science Institute, RIKEN, Japan 日本理化學研究所腦科學 綜合研究中心 Minmin Luo, National Institute of Biological Sciences, China 中國北京生命科學研 究所 PROGRAM DEVELOPMENT AND GENETICS OF NEURAL CIRCUITS Y. Hayashi, RIKEN Brain Science Institute, Saitama, Japan DEVELOPMENT AND APPLICATION OF CUTTINGEDGE TECHNOLOGIES G. Feng, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA CIRCUIT MECHANISMS OF PERCEPTION, COGNITION AND DECISION I M. Luo, National Institute of Biological Sciences, China KEYNOTE SPEAKER Ann M. Graybiel, Massachusetts Institute of Technology, USA 美國麻省理工學院 CIRCUIT MECHANISMS OF PERCEPTION, COGNITION AND DECISION II K. Kuroda, RIKEN Brain Science Institute, Saitama, Japan CIRCUIT MECHANISMS OF LEARNING, MEMORY AND PLASTICITY I B. Poucet, CNRS, Aix-Marseille University, France CIRCUIT MECHANISMS OF LEARNING, MEMORY AND PLASTICITY II S. Chattarji, National Centre for Biological Sciences, Bangalore, India NEUROMODULATORS IN CIRCUIT FUNCTION AND BEHAVIOR J. Gordon, Columbia University, New York, New York, USA CIRCUIT DYSFUNCTION AND PSYCHIATRIC DISORDERS R. Costa, Champalimaud Neuroscience Program, Lisboa, Portugal 27 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia INVITED SPEAKERS Le Cong, Broad Institute, Harvard Medical School, USA 美國哈佛大學腦科學研究所 Rui M. Costa, Champalimaud Neuroscience Program, Portugal 葡萄牙Champalimaud基金神經科學專案 Yang Dan, University of California, Berkeley, USA 美國加利福尼亞大學伯克利分校 Guoping Feng, Massachusetts Institute of Technology, USA 美國麻省理工學院 Brigitta Gundersen, Nature Publishing Group, USA 美國自然出版社 Joshua A. Gordon, Columbia University, USA 美國哥倫比亞大學 Jin-Hee Han, KAIST, KOREA 韓國科學技術院 Yasunori Hayashi, Brain Science Institute, RIKEN, Japan 日本理化學研究所腦科學綜合研究中心 Hailan Hu, Shanghai Institutes for Biological Sciences, CHINA 中國科學院神經科學研究所 Z. Josh Huang, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 Inbal Israely, Champalimaud Foundation, PORTUGAL 葡萄牙Champalimaud基金神經科學專案 Kumi O. Kuroda, RIKEN Brain Science Institute, JAPAN 日本理化學研究所腦科學綜合研究中心 Inah Lee, Seoul National University, KOREA 韓國首爾大學 Bo Li, Cold Spring Harbor Laboratory, USA 美國冷泉港實驗室 Wu Li, Beijing Normal University, CHINA 中國北京師範大學 Yingxi Lin, McGovern Institute for Brain Research at MIT, USA 美國麻省理工學院麥戈文人腦研究院 Minmin Luo, National Institute of Biological Sciences, China 中國北京生命科學研究所 Suresh Jesuthasan, A*Star-Duke/NUS, Singapore 新加坡科技研究局/新加坡國立大學 Bruno Poucet, Aix-Marseille University and CNRS, FRANCE 法國馬賽第三大學/法國國家科學研究院 Mark J. Schnitzer, HHMI / Stanford University, USA 美國霍華德?休斯醫學研究所/美國斯坦福大學 Song-Hai Shi, MSKCC, USA 美國紀念斯隆-凱特琳癌症中心 Yi Rao, Peking University, CHINA 中國北京大學 Naoshige Uchida, Harvard University, USA 美國哈佛大學 Dai Watanabe, Kyoto University Faculty of Medicine, JAPAN 日本京都大學醫學院 Yoshihiro Yoshihara, RIKEN Brain Science Institute, JAPAN 日本理化學研究所腦科學綜合研究中心 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 28 CSHA/ICMS JOINT CONFERENCE ON TUMOR MICROENVIRONMENT CSHA/ ICMS 聯合會議:腫瘤微環境 November 13 - 17 TARGETING THE TUMOR MICROENVIRONMENT F. Balkwill, Queen Mary University of London, United Kingdom PARALLEL SYMPOSIUM SESSIONS 4-5 INFLAMMATION AND IMMUNITY IN THE TUMOR MICROENVIRONMENT 240 Participants ORGANIZED BY Frances Balkwill, Queen Mary University of London, UK 英國倫敦大學瑪麗女王學院 Wolf Fridman, Cordeliers Research Centre, France 法國科德利埃研究中心 Luyuan Li, Nankai University School of Pharmaceutical Science, China 中國南開大學藥學院 Abraham Raz, Wayne State University, USA 美國韋恩州立大學 Eiichi Tahara, Hiroshima Cancer Seminar Foundation, Japan 日本廣島癌症基金會研討會 Isaac Witz, Tel Aviv University, Israel 以色列特拉維夫大學 PROGRAM IMMUNITY IN THE TUMOR MICROENVIRONMENT W. H. Fridman, Cordeliers Research Centre, Paris, France REGULATORY EVENTS IN THE TUMOR MICROENVIRONMENT X. Cao, Chinese Academy of Medical Sciences, Beijing, China REGULATORY EVENTS IN THE TUMOR MICROENVIRONMENT X. Cao, Chinese Academy of Medical Sciences, Beijing, China INFLAMMATION IN THE TUMOR MICROENVIRONMENT L. Li, Nankai University School of Pharmaceutical Science, Tianjin, China PARALLEL SYMPOSIUM SESSIONS 1-3 REGULATORY NETWORKS IN THE TUMOR MICROENVIRONMENT D. Hoon, John Wayne Cancer Institute, Santa Monica, California, USA A. Thomas-Tikhonenko, University of Pennsylvania School of Medicine, Philadelphia, USA FUNCTIONAL GENETICS OF FIBROBLASTS IN THE TUMOR MICROENVIRONMENT A. Ostman, Karolinska Institutet, Stockholm, Sweden J.-P. Abastado, A-STAR, Singapore A. Porgador, Ben Gurion University of the Negev, Beer Sheva, Israel TARGETING THE TUMOR AND THE TUMOR MICROENVIRONMENT R. Ge, National University of Singapore, Singapore T . ten Hagen, Erasmus Medical Center, Rotterdam, the Netherlands KEYNOTE SPEAKERS Carlo Croce, Ohio State University, USA 美國俄亥俄州立大學 Robert Gallo, University of Maryland, USA 美國馬里蘭大學 Peter H. Krammer, German Cancer Research Center, Germany 德國癌症研究中心 INVITED SPEAKERS Heike Allgayer, University of Heidelberg, Germany 德國海德堡大學 Ron Apte, Ben Gurion University,Faculty of Health Sciences, ISRAEL 以色列本?古裏安大學 醫學院 Frances Balkwill, Queen Mary University of London, UK 英國倫敦大學瑪麗女王學院 Menashe Bar-Eli, M.D. Anderson Cancer Center, USA 美國安德森癌症研究中心 Adit Ben-Baruch, Tel Aviv University, ISRAEL 以色列特拉維夫大學 Xuetao Cao, Chinese Academy of Medcial Sciences, CHINA 中國醫學科學院 Neta Erez,Tel Aviv University, ISRAEL 以色列特拉維夫大學 Wolf Fridman, Cordeliers Research Centre, FRANCE 法國科德利埃研究中心 Bernd Groner, Georg Speyer Haus, Germany 德國Georg Speyer Haus生物醫學研究所 Theresa Guise, Indiana University School of Medicine, USA 美國印第安那大學醫學院 Canhua Huang, West China Hospital / Sichuan University, CHINA 中國四川大學華西醫院 Yutaka Kawakami, Keio University School of Medicine, JAPAN 日本慶應義塾大學醫學部 Robert S. Kerbel, Sunnybrook Research Institute, Toronto, Canada 加拿大多倫多新寧研究院 Yona Keisari,Tel Aviv University, Sackler Faculty of Medicine, ISRAEL 以色列特拉維夫大學醫學系 Luyuan Li, Nankai University School of Pharmaceutical Science, CHINA 中國南開大學藥學院 Yongzhang Luo, Tsinghua University, China 中國清華大學 Alberto Mantovani, Istituto Clinico Humanitas IRCCS, ITALY 義大利IRCCS醫學中心 Senthil Muthuswamy, University of Toronto, CANADA 加拿大多倫多大學 Takahiro Ochiya, National Cancer Center, Research Institute, JAPAN 日本國立癌症研究中心 Jacques Pouyssegur, Centre National de la Recherche Scientifique, FRANCE 法國國家科學研究中心 Avraham Raz, Wayne state University, USA 美國韋恩州立大學 Michael Shurin, University of Pittsburgh Medical Center, USA 美國匹茲堡大學醫療中心 Hidetoshi Tahara, Hiroshima University, Japan 日本廣島大學 Eitan Yefenof, Hebrew University-Hadassah Medical School, ISRAEL 以色列希伯來大學哈達薩醫學院 Danfang Zhang, Cancer Hospital of Tianjin Medical University, China 中國天津大學附屬腫瘤醫院 CYTOKINE AND CHEMOKIINE NETWORKS IN THE TUMOR MICROENVIRONMENT L. Borsig, University of Zurich, Switzerland REGULATORY EVENTS IN THE TUMOR MICROENVIRONMENT III A. Raz, Wayne State University, Detroit, Michigan, USA 29 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 30 SYNTHETIC BIOLOGY 合成生物學 KEYNOTE SPEAKERS Birger Lindberg Møller, University of Copenhagen, Denmark 丹麥哥本哈根大學 Lars K. Nielsen, The University of Queensland, AUSTRALIA 澳大利亞昆士蘭大學 Sven Panke, ETH Zürich SWITZERLAND 瑞士蘇黎世理工學院 INVITED SPEAKERS November 26 - 30 174 Participants ORGANIZED BY Guoqiang Chen, Tsinghua University, China 中國清華大學 Sang Yup Lee, Korea Advanced Institute of Science and Technology, Korea 韓國科學技術學院 Birger Lindberg Møller, University of Copenhagen, Denmark 丹麥哥本哈根大學 Hiroki Ueda, RIKEN Kobe Institute, Japan 日本神戶理化研究所 PROGRAM PROKARYOTIC GENOME ENGINEERING G. Guo-Qiang Chen, Tsinghua University, Beijing, China GENOME ENGINEERING OF EUKARYOTIC SYSTEMS I Hal Alper, The University of Texas at Austin, USA 美國德克薩斯大學奧斯丁分校 Caroline M. Ajo-Franklin, Lawrence Berkeley National Laboratory, USA 美國勞倫斯伯克力國家實驗室 George Guo-Qiang Chen, Tsinghua University, CHINA 中國清華大學 Byung-Kwan Cho, KAIST, KOREA 韓國科學技術院 Lothar Eggeling, Forschungszentrum Jülich, Germany 德國於利希研究中心 Victor de Lorenzo, Centro Nacional de Biotecnologia SPAIN 西班牙國立生物技術中心 Justin P. Gallivan, Emory University, USA 美國埃默里大學 Ulrik Gether, University of Copenhagen, Denmark 丹麥哥本哈根大學 Ramon Gonzalez, Rice University, USA 美國萊斯大學 Björn Hamberger, University of Copenhagen, Denmark 丹麥哥本哈根大學 Yu-Sin Jang, KAIST, South Korea 韓國科學技術院 Gyoo Yeol Jung, POSTECH, South Korea 韓國浦項科技大學 Sun Chang Kim, Korea Advanced Institute of Sciences and Technology, South Korea 韓國科學技術院 Jin-Soo Kim, Seoul National University, KOREA 韓國首爾大學 Yin Li, Institute of Microbiology, CAS, CHINA 中國科學院微生物研究所 Qi Ouyang, Peking University, CHINA 中國北京大學 Brian F. Pfleger, The University of Wisconsin-Madison, USA 美國威斯康星大學麥迪森分校 Henrik Vibe Scheller Joint BioEnergy Institute, USA 美國能源部聯合生物能源研究所 Dimitrios Stamou, University of Copenhagen, Denmark 丹麥哥本哈根大學 Hiroki R. Ueda, RIKEN Kobe Institute, JAPAN 日本神戶理化研究所 Daisuke Umeno, Chiba University, JAPAN 日本千葉大學 Horst Vogel, école Polytechnique Fédérale de Lausanne, Switzerland 瑞士洛桑聯邦理工大學 Antonio Villaverde, Universitat Autònoma de Barcelona, SPAIN 西班牙巴賽隆納自治大學 Tom Vosch, University of Copenhagen, Denmark 丹麥哥本哈根大學 Yi Yang, East China University of Science and Technology, CHINA 中國華東理工大學 Tetsuya Yomo, Osaka University, Japan 日本大阪大學 Yeo Joon Yoon, Ewha Womans University, KOREA 韓國梨花女子大學 Oliver Yu, Wuxi New Way Biotechnology Co. China 中國無錫新和源有限公司 Guoping Zhao, Shanghai Institute of Biological Sciences, CAS, China 中國科學院上海生物科學研究所 Huimin Zhao, University of Illinois at Urbana-Champaign, USA 美國厄巴納伊利諾斯州大學 V. de Lorenzo, CSIC National Center for Biotechnology, Madrid, Spain GENOME ENGINEERING OF EUKARYOTIC SYSTEMS II H.R. Ueda, RIKEN, Kobe, Japan DESIGNING CELLULAR CIRCUITS H. Alper, University of Texas at Austin, Austin, Texas, USA METABOLIC ENGINEERING FOR CHEMICALS, FUELS AND MATERIALS I L. Eggeling, Forschungszentrum Jülich, Jülich, Germany METABOLIC ENGINEERING FOR CHEMICALS, FUELS AND MATERIALS II H. Zhao, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA EMERGING TOOLS OF SYNTHETIC BIOLOGY L. Eggeling, Forschungszentrum Jülich, Jülich, Germany 31 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 32 STEM CELLS AND DEVELOPMENTAL MECHANISMS 幹細胞與發育機理 ASYMMETRIC CELL DIVISION AND STEM CELL REGULATION W. Zhong, Yale University, New Haven, Connecticut, USA STEM CELL DIFFERENTIATION AND DEDIFFERENTIATION H. Lin, Yale University School of Medicine, New Haven, Connecticut, USA KEYNOTE SPEAKERS Allan C. Spradling, HHMI / Carnegie Institution for Science, USA 美國霍華德.休斯醫學研究所/美國卡耐基研究所 Clifford J. Tabin, Harvard Medical School, USA 美國哈佛大學醫學院 INVITED SPEAKERS December 3 - 7 164 Participants ORGANIZED BY Thomas Bosch, Christian-Albrechts-University Kiel, Germany 德國基爾大學 Yukiko Gotoh, University of Tokyo, Japan 日本東京大學 Ting Xie, Stowers Institute for Medical Research, USA 美國斯托爾斯醫學研究所 Weimin Zhong, Yale University, USA 美國耶魯大學 PROGRAM STEM CELLS AND EVOLUTION Y. Gotoh, University of Tokyo, Japan NEURAL STEM CELL REGULATION Z. He, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA STEM CELL SELF-RENEWAL AND DIFFERENTIATION MECHANISMS A. Spradling, HHMI/Carnegie Institution of Washington, Baltimore, Maryland, USA SMALL RNAs, CHROMATIN AND STEM CELLS Alejandro Sánchez Alvarado, HHMI / Stowers Institute for Medical Research, USA 美國霍華德.休斯醫學研究所/美國斯托爾斯 醫學研究所 Thomas C.G. Bosch, Christian-Albrechts-University Kiel, Germany 德國基爾大學 Yu Cai, Temasek Life Sciences Laboratory, SINGAPORE 新加坡淡馬錫生命科學實驗室 Hongkui Deng, Peking University, College of Life Sciences, CHINA 中國北京大學生命科學院 Charles Durand, University Pierre and Marie Curie, UMR CNRS 7622, FRANCE 法國巴黎第六大學 Wei-Qiang Gao, Shanghai Jiao Tong University, CHINA 中國上海交通大學 Yukiko Gotoh, University of Tokyo, Japan 日本東京大學 Zhigang He, Harvard Medical School/Children's Hospital, Boston, USA 美國哈佛醫學院/波士頓兒童醫院 Ying Jin, Shanghai Jiaotong Univeristy/Shanghai Institutes for Biological Sciences, China 中國上海交通大學/中國科學院上海生 物科學研究所 Naihe Jing, Shanghai Institute for Biological Sciences, CAS, China 中國科學院上海生物科學研究所 Juergen Knoblich, Institute of Molecular Biotechnology, AUSTRIA 奧地利分子生物技術研究所 Arnold R. Kriegstein, University of California at San Francisco, USA 美國加州大學三藩市分校 Linheng Li, Stowers Institute for Medical Research, USA 美國斯托爾斯醫學研究所 Jinsong Li, Shanghai Institutes for Biological Sciences, China 中國科學院上海生命科學研究院 Haifan Lin, Yale University School of Medicine, USA 美國耶魯大學醫學院 Jan U. Lohmann, Heidelberg University, Germany 德國海德堡大學 Hiromitsu Nakauchi, University of Tokyo, JAPAN 日本東京大學 Duanqing Pei, Guangzhou Institute of Biomedicine and Health,CAS, China 中國科學院廣州生物醫藥與健康研究院 Olivier Pourquié, Institute of Genetics and Molecular and Cellular Biology, FRANCE 法國分子細胞遺傳研究所 Norbert Perrimon, HHMI / Harvard Medical School, USA 美國霍華德.休斯醫學研究所/哈弗醫學院 Yun-Bo Shi, NICHD, NIH, United States 美國國家兒童保健和人類發育研究所/美國國立衛生研究院 Dolf Weijers, Wageningen University, THE NETHERLANDS 荷蘭瓦赫寧根大學 Ting Xie, Stowers Institute for Medical Research, USA 美國斯托爾斯醫學研究所 Xiaohang Yang, Zhejiang University, CHINA 中國浙江大學 Weimin Zhong, Yale University, USA 美國耶魯大學 Qi Zhou, Institute of Zoology, CAS, CHINA 中國科學院動物所 T. Bosch, Christian-Albrechts-University Kiel, Germany TISSUE DEVELOPMENT AND REGENERATION C. Tabin, Harvard Medical School, Boston, Massachusetts, USA 33 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 34 THE 3RD COMPUTATIONAL AND COGNITIVE NEUROBIOLOGY (CCN) SUMMER SCHOOL 第三期計算認知神經生物學暑期班 July 14-31 INSTRUCTORS: Xiao-Jing Wang, Yale University School of Medicine, USA Si Wu, Institute of Neuroscience, Shanghai, CHINA Upinder S Bhalla, Natl Ctr Biological Science, Bangalore, INDIA Zachary F Mainen, Instituto Gulbenkian de Ciência, PORTUGAL INVITED LECTURERS: Matteo Carandini, UCL, UK Bob Desimone, MIT, USA Kenji Doya, Okinawa Institute of Science and Technology,JAPAN Ila Fiete, University of Texas at Austin USA Paul Glimcher, NYU USA ZhaoPing Li, Tsinghua University and UCL CHINA/UK / Weiji Ma, Baylor College of Medicine USA David McCormick, Yale University USA Philip Sabes, University of California at San Francisco, USA Haim Sompolinsky, Hebrew University ISRAEL 35 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia The 3rd Computational and Cognitive Neurobiology Summer School was held in Beijing, China. The objective of this course is to train in Computational Neuroscience talented and highly motivated students and postdocs from Asia and other countries in the world. Students are with either quantitative, including Physics, Mathematics, Engineering and Computer Science or experimental background. The lectures introduced the basic concepts and methods, as well as cutting-edge research, in Computational and Systems/Cognitive Neurosciences. Modeling will be taught at multiple levels, ranging from subcellular processes, single neuron computation, to microcircuits and large-scale systems. Matlab-based programming labs coordinated with the lectures provided practical training in important computational methods. 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 36 CSH ASIA FELLOWSHIPS RNA Biology Yang Yu, Cold Spring Harbor Lab, USA Yang Lv, Sun Yat-sen University, China Akiko Noma, UMASS Medical School/HHMI, USA Paula Vazquez, Bern University, Switzerland 冷泉港亞洲獎學金 Organizers of each CSH Asia meeting select fellowship awards from the submitted abstracts by graduate students and postdoc fellows on the merit of scientific quality. Congratulations to the following students! Their presentations (short talks or posters) are selected for CSHA fellowships in 2012. Fishing for Answers: Zebrafish Models of Human Development and Disease (Sponsored by the Company of Biologists) Andrew Badrock, Ludwig Institute for Cancer Research, Australia Harriet Jackson, A*STAR, Singapore Shizhen Zhu, Dana-Farber Cancer Institute, USA Anne Robertson, University of Sheffield UK Yi Feng, University of Bristol, UK Chao Liu, Institute of Genetics and Developmental Biology, China Kerrie Taylor, Edinburgh Cancer Research Centre, UK Jin Xu, HKUST, China Sujuan Jia, St Jude Children's Research Hospital, USA Suzanne Ridges, Huntsman Cancer Institute, USA Michiel van der Vaart, University Leiden, Netherlands Leah Liu, Brigham and Women's Hospital, Harvard Medical School, USA Viviana Gallardo, National Institutes of Health, USA Mingyu Li, Vanderbilt University School of Medicine, USA Ying Wang, Temasek Life Sceinces Lab. Singapore Chao-Tsung Yang, University of Washington, USA Vanessa Damoulis, UT Southwestern Medical Center, USA Oscar Pena, Universidad de Chile, Chile Lin Guo, A*STAR, Singapore Epigenetics, Chromatin & Transcription (Sponsored by Cell Research) Wulan Deng, The Children’s Hospital of Philadelphia, USA Jie Ren, Cold Spring Harbor Laboratory, USA Erin A. Clark, Harvard Medical School, USA Jee-In Kim, Kyungpook National University, Korea Liangyu Liu, Max Planck Institute for Plant Breeding Research, Cologne, Germany Xuehua Zhong, University of California Los Angeles, USA Hatsune Chiba, Kyushu University, Fukuoka, Japan Xiang Zhou, National Laboratory of Biomacromolecules, Beijing, China Neelam A. Kedia Mokashi, National Institute for Research in Reproductive Health, Mumbai, India Liver Metabolism, Disorders and Cancer Ying Xu, Sun Yat-sen University, China Ines Jeric, University of Vienna, Austria Bone and Cartilage: from Development to Human Diseases Bau-Lin Huang, National Cancer Institute, USA Yoshiki Minegishi, Kyoto University, Japan Hwanhee Oh, Gwangju institute of science and technology (GIST), Korea Cheng Wang, the University of Hong Kong, China M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA 37 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia High Throughput Biology, Genomics & Epigenomics Zhuzhu Zhang, University of North Carolina at Chapel Hill, USA Jian Yan, Karolinska Institutet, Sweden Chloe Rivera, UCSD/LICR, USA Chunhui Hou, Emory University, USA Invertebrate Neurobiology Differentiation Therapy and Advances in Cancer Tong-Wey Koh, Yale University, USA Wen-Feng Chen, HHMI / University of Pennsylvania, USA Li-Ting Chen, Shanghai Institute of Hematology, China Jie Xu, Shanghai Jiao Tong University, China Frontiers of Immunology in Health and Diseases Plant Epigenetics, Stress and Evolution Peter Crisp, Australian National University, Australia Hsiao-Lin Wang, University of Missouri-Kansas City, USA Pei Zhang, University of Southern California, USA Josipa Raguz, University of Vienna, AUSTRIA Xuefu Wang, School of Life Sciences, USTC, CHINA Koon-Guan Lee, Bioprocessing technology institute, SINGAPORE Neural Circuit Basis of Behavior and its Disorders Invertebrate Neurobiology Zhuohao He, Institute of Neuroscience, CAS, China Quan Wen, Harvard University, USA Yuanyuan Yao, Institute of Neuroscience, CAS, China Tong-Wey Koh, Yale University, USA Wen-Feng Chen, HHMI / University of Pennsylvania, USA Frontiers of Immunology in Health and Diseases Josipa Raguz, University of Vienna, AUSTRIA Xuefu Wang, School of Life Sciences, USTC, CHINA Koon-Guan Lee, Bioprocessing technology institute, SINGAPORE Ion channels: Biophysics, Diseases and Therapeutics Small GTPases at Different Scales: Proteins, Membranes, Cells Cyrille BILLAUDEAU, CNRS, France Hotaka Kobayashi, Tohoku University, Japan Kenji Matsuzawa, Nagoya University Graduate School of Medicine, Japan Matthias Mueller, Max-Planck-Institute for Molecular Physiology, Germany Till Rudack, Ruhr University Bochum, Germany Tumor Microenvironment Valerie Chew, Singapore Immunology Network, Singapore Jing Jiao, University of California Los Angeles, USA Yuanyuan Wang, CNRS, France Synthetic Biology Haoqian Zhang, Peking-Tsinghua Joint Center for Life Sciences, China Zakir Tnimov, The University of Queensland, Australia Tong Un Chae, KAIST, South Korea Yan Zhang, Tsinghua University, China Guodong Luan, Institute Of Microbiology Chinese Academy of Science, China SungHo Jang, POSTECH, South Korea Stem Cells and Developmental Mechanisms Daijiro Konno, RIKEN, Japan Chenhui Wang, National institute of biological sciences, Beijing, China Li Wang, National Institute of Environmental Health Sciences, USA Cheng-Ran Xu, University of Pennsylvania, USA 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 38 THE LEADING STRAND 線上視頻會議 http://theleadingstrand.cshl.edu/ The Leading Strand web portal features a combination of freely available and private web sites including meeting video archives, meeting photo albums, online courses and public lectures. Access to some of these resources depends on prior attendance at an individual meeting. Other resources are open or require a simple free registration process. Cold Spring Harbor Asia offers archived streaming video of the oral sessions of each meeting through this Leading Strand web site. Speakers could choose whether their talks are recorded or not. If the talk is allowed to be recorded, the video will be available to review for meeting attendees only and on a password-accessible basis. Otherwise, speakers’ talks will not be archived or recorded at all. 39 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia OVERALL STATISTLCS SCIENTIFIC ADVISORY BOARD 統計資料 科學顧問委員會 HONORARY SCIENTIFIC ADVISORY BOARD 2011, the third year of Cold Spring Harbor Asia consisted with 17 conferences (6 spring conferences and 11 fall conferences) and 1 summer course. Many conferences are becoming real series meetings, which keep on repeating every 1 or 2 years, such as the epigenetics meeting, the system biology meeting, etc. More than 3100 scientists have joined CSH Asia’s meetings and course. Nobel laureate Dr. Martin Chalfie attended and delivered his keynote lecture at the CSH Asia meeting on Invertebrate Neurobiology. CSH Asia is glad to have a joint conference with ICMS for a meeting on Tumor Microenvironment. Our statistics show that there were totally 2576 registrants (including 463 student auditors and 96 representatives from the local biotech companies) from 49 countries who have participated in the seventeen meetings and the summer course. In general, female participants took about 36.5% of the total participants. Number of Meetings Number of Summer Course Total Participants Free Auditing Students Representatives from Local Biotech Companies Female Male 17 1 3126 463 96 36.5% 63.5% Gender Proportion James D. Watson Zhu Chen Zhou Guang Zhao Cold Spring Harbor Laboratory, USA Ministry of Health, China Chinese Association for Science & Technology, China SCIENTIFIC ADVISORY BOARD Attendee by Position Attendee Grographic Distribution D. Balasubramanian Nam-Hai Chua Lab Head Professor Medical Doctors China (Inlucding WP* Students) North America Staff Scientist Post Doc Graduate Student Europe Asia-Pacific Region Media Other Indian Academy of Sciences, India The Rockefeller University, USA David Ho Nancy Ip Jiayang Li Edison Liu Rick Morimoto The Rockefeller University, USA Hong Kong University of Science & Technology, Hong Kong Chinese Academy of Sciences, China Genome Institute of Singapore,Singapore Northwestern University, USA Mu-Ming Poo Bruce Stillman Patrick Tam University of California Berkeley, USA Cold Spring Harbor Laboratory, USA University of Sydney, Australia Other Attendee Number by Meeting/Course 461 Shin-Ichi Nishikawa Svante Paabo 259 241 172 114 123 121 174 164 University of Tokyo, Japan Hong Kong University, Hong Kong 83 ITR A 240 Tadatsugu Taniguchi Lap-Chee Tsui A-E P A-Z EB R 185 151 156 144 Max Planck Institute, Germany AN S A- G EN IM E A-L IVE R A-B ON E A-N EU RO A-I MM UN E A-I ON A-R AS A-R NA A-S YS TE M A-D IFF ER A-P LA NT A-C IRC UIT A-T UM OR A-S YN TH ES I A-S TE M 62 219 RIKEN Center for Developmental Biology, Japan In terms of geographic distribution, the top 5 countries/regions from which we have the most attendees are China (including HK) (1750), USA (466), South Korea (135), Japan (120) and Singapore (90). 41 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia M. Vijayan Indian National Science Academy, India Andrew H. J. Wang Xiaodong Wang Xiaoliang(Sunney)Xie Jeongbin Yim Michael Zhang National Institute of Biological Sciences, Beijing, China Seoul National University, Korea Cold Spring Harbor Laboratory, USA Academia Sinica, Taiwan Harvard University, USA 2012 CONFERENCES AND COURSE PROGRAM Cold Spring Harbor Asia 42