memoria de investigación hospital clínico san carlos
Transcription
memoria de investigación hospital clínico san carlos
2009 MEMORIA DE INVESTIGACIÓN HOSPITAL CLÍNICO SAN CARLOS Elaborado por: Fundación para la Investigación Biomédica del HCSC Muchas gracias a Náyade del Prado, Manuel Espantaleón y Emilio Vargas por su colaboración en la elaboración de este documento 1 Índice Publicaciones científicas 1. Estrategia de búsqueda bibliográfica…………………………………………………………… 4 2. Número de publicaciones según tipo…………………………………………………………… 4 3. Idioma de las publicaciones…………………………………………………………………………. 5 4. Factor de impacto y distribución en cuartiles por tipo de publicación ............ 5 5. Evolución del factor de impacto de los artículos originales desde el año 2000 6 6. Número de publicaciones por área temática de la WOK………………………………. 7 7. Listado de los investigadores con mayor número de publicaciones (mínimo 7) y mayor factor de impacto total (mínimo 25)…………………………………………… 8 Proyectos de investigación 8. Solicitudes en concurrencia competitiva……………………………………………………… 11 9. Proyectos obtenidos en concurrencia competitiva y activos en 2009…………... 12 10. Ensayos clínicos…………………………………………………………………………………………… 13 Anexos 11. Listado de publicaciones del HCSC correspondientes al año 2009………………… 14 12. Listado de proyectos competitivos del HCSC activos durante el año 2009…. 52 2 Publicaciones científicas 3 1. Estrategia de búsqueda bibliográfica Se realizó una búsqueda bibliográfica en Web of Knowledge (WOK) de ISI. La búsqueda se realizó en la sección ‘All Databases’ con las variantes: Clin OR Clin OR Clinico OR Univ OR Universitario OR Universitary en Address AND S Carlos OR San Carlos en Address AND Hosp* en Address AND Year Published = 2009. El resultado se exporta mediante Output Records seleccionando Step 1 Todos los Records, Step 2 plus Abstract y Step 3 Save to Plain Text y posteriormente desde este archivo a Excel. 2. Número de publicaciones según tipo Correction 3 (0,6%) Proceedings Paper 19 (3,9%) Review 33 (6,7%) Letter 38 (7,7%) Editorial Material 32 (6,5%) Meeting Abstract 100 (20,3%) Article 268 (54,4%) 0 50 100 150 200 250 300 Figura 1. Número de publicaciones según tipo. El 75% de las publicaciones científicas del Hospital Clínico San Carlos durante el año 2009 se correspondieron con artículos originales y abstracts. 4 3. Idioma de las publicaciones 2. Número de publicaciones según tipo Figura 2. Idioma de publicación. 4. Factor de impacto y distribución en cuartiles por tipo de publicación (JCR 2009) Tabla 1. Factor de impacto y distribución en cuartiles según el tipo de publicación Tipo de publicación Article Proceedings paper Review Total general Tipo de publicación Article Proceedings paper Review Total general Q1 81 2 15 98 (31,1%) Factor de impacto Total Medio 827,24 3,09 40,98 2,16 100,15 3,03 968,36 3,03 Nº de publicaciones Q3 Q2 50 71 5 5 5 7 60 (26,3%) 83 (26,3%) Q4 62 7 5 74 (23,5%) 5 5. Evolución del factor de impacto de los artículos originales desde el año 2000 En la Figura 2 se presenta la evolución del factor de impacto total de los artículos originales publicados desde el año 2000. El factor de impacto del periodo 2000-2007 se ha extraído de las memorias de investigación realizadas por la Unidad de Apoyo Metodológico del Hospital Clínico San Carlos. La metodología empleada en la elaboración de las memorias del periodo 2000-2007 frente a la empleada en las memorias 2008-2009 es diferente, circunstancia que debe tenerse en cuenta al interpretar el ascenso en el impacto de los dos últimos año; las memorias del periodo 2000-2007 tomaban como unidad de análisis las publicaciones notificadas por los servicios del hospital, mientras que las memorias de los años 2008 y 2009 obtienen la información de búsquedas bibliográficas en bases de datos electrónicas. 900 827,24 751,70 Factor de impacto total 800 700 630,11 600 562,76 2005 2006 457,53 500 400 556,05 329,45 358,96 310,41 292,44 2002 2003 300 200 100 0 2000 2001 2004 2007 2008 2009 Año Figura 3. Evolución del factor de impacto total desde el año 2000. 6 6. Número de publicaciones por área temática de la WOK Tabla 2. Número de publicaciones por área temática de la WOK. Área temática Allergy; Immunology Tipo de publicación Article Review Automation & Control Systems; Computer Science, Artificial Intelligence Article Behavioral Sciences; Clinical Neurology; Psychiatry Article Biochemical Research Methods; Biochemistry & Molecular Biology Review Biochemistry & Molecular Biology Article Biophysics; Engineering, Biomedical; Physiology Article Biotechnology & Applied Microbiology; Genetics & Heredity Article Cardiac & Cardiovascular Systems Article Proceedings paper Cell Biology; Immunology; Pathology Article Chemistry, Medicinal Article Clinical Neurology Article Proceedings Paper Review Computer Science, Interdisciplinary Applications Article Dentistry, Oral Surgery & Medicine Review Dermatology Article Endocrinology & Metabolism Article Engineering, Multidisciplinary Article Environmental Sciences Article Gastroenterology & Hepatology Article Review Genetics & Heredity Article Geriatrics & Gerontology Article Health Care Sciences & Services Article Hematology Article Immunology Article Proceedings paper Infectious Diseases Article Proceedings Paper Review Medicine, General & Internal Article Medicine, Research & Experimental; Pathology Article Multidisciplinary Sciences Article Mycology; Veterinary Sciences Article Neurosciences Article Proceedings paper Review Nursing Article Obstetrics & Gynecology Article Oncology Article Proceedings Paper Review Ophthalmology Article Proceedings paper Nº 7 1 1 2 1 8 1 2 38 3 3 1 25 1 4 1 1 1 8 1 2 13 2 4 1 1 9 10 9 6 2 1 13 1 1 1 5 1 3 1 1 29 1 8 12 1 7 Tabla 2. Número de publicaciones por área temática de la WOK. Área temática Otorhinolaryngology Pediatrics Peripheral Vascular Disease Pharmacology & Pharmacy Psychiatry Psychology, Clinical Public, Environmental & Occupational Health Radiology, Nuclear Medicine & Medical Imaging Respiratory System Rheumatology Tipo de publicación Article Article Article Article Article Article Article Article Article Article Proceedings Paper Review Article Review Article Review Article Surgery Urology & Nephrology Virology Total general Nº 1 2 3 3 6 8 5 4 3 12 1 4 6 1 11 1 1 320 7. Listado de los investigadores con mayor número de publicaciones (mínimo 7) y mayor factor de impacto total (mínimo 25) Investigador Gómez de la Concha, Emilio Urcelay, Elena Fernández-Arquero, Miguel Martínez, Alfonso Macaya, Carlos Martín, Miguel Díaz-Rubio, Manuel Pérez de Isla, Leopoldo Zamorano, José Luis Sastre, Javier Pérez-Flores, Isabel Núñez, Concepción López-Ibor, Juan José Díaz-Rubio, Eduardo Taxonera, Carlos Calvo, Natividad Mendoza, Juan Luis Fernández-Gutiérrez, Benjamín Barquero, María Sagrario Servicio Inmunología Inmunología Inmunología Inmunología Cardiología Oncología Ap. Digestivo Cardiología Cardiología Oncología Nefrología Inmunología Psiquiatría Oncología Ap. Digestivo Nefrología Ap. Digestivo Reumatología Neurología Nº de publicaciones 18 16 15 13 12 10 10 10 9 9 9 9 8 8 7 7 7 7 7 8 Investigador Gómez de la Concha, Emilio González-Larriba, José Luis Urcelay, Elena Macaya, Carlos Fernández-Arquero, Miguel Martínez, Alfonso Lopez-Ibor, Juan José Martín, Miguel Bañuelos, Camino Díaz-Rubio, Manuel Alfonso, Fernando Núñez, Concepción Hernández, Rosa Ana Escaned, Javier Jiménez-Quevedo, Pilar Fernández-Gutiérrez, Benjamín Aragoncillo, Paloma Taxonera, Carlos Mendoza, Juan Luis Díaz-Rubio, Eduardo Fernández-Rivas, Montserrat Servicio Suma de FI Inmunología 62,55 Oncología 59,90 Inmunología 58,72 Cardiología 51,87 Inmunología 50,39 Inmunología 45,98 Psiquiatría 38,27 Oncología 36,18 Cardiología 35,59 Ap. Digestivo 34,89 Cardiología 32,46 Inmunología 31,15 Cardiología 30,10 Cardiología 30,10 Cardiología 30,10 Reumatología 29,44 Anat. Patológica 27,85 Ap. Digestivo 27,38 Ap. Digestivo 26,10 Oncología 25,91 Alergia 25,35 9 Proyectos de investigación 10 8. Solicitudes concedidas en concurrencia competitiva Durante el año 2009 fueron concedidos, en concurrencia competitiva, un total de 29 proyectos en el Hospital Clínico San Carlos (HCSC), ascendiendo a 2.346.101€ concedidos por las entidades financiadoras para todas las anualidades de los proyectos. El 76% de las solicitudes se presentaron a agencias públicas de financiación y el 24% a entidades privadas. La Figura 4 resume el número de solicitudes por tipo de convocatoria. MICINN-Investigación Fundamental 1 MICINN-Estrategias y ERANETS 1 MICINN-Infraestructuras 1 MSPS-Traslación Apl. Terapéutica 1 ISCIII-AES-RETICS 2 CE/PROGRAMA MARCO 2 ISCIII-AES-Evaluación Tec. Sanitarias 4 ISCIII-AES-Proyectos de investigación 5 MSPS-Estrategias de Salud 5 FMM 7 0 1 2 3 4 5 6 7 8 Figura 4. Número de proyectos concedidos en 2009 en convocatorias competitivas. 11 9. Proyectos obtenidos en concurrencia competitiva y activos en 2009 Durante el año 2009 la Fundación para la Investigación Biomédica del Hospital Clínico San Carlos (FIBHCSC) tenía registrados como activos un total de 148 proyectos obtenidos en concurrencia competitiva; el 56,1% tenían financiación pública, un 37,8% financiación privada y el 6,1% estaban cofinanciados. El 94% de los proyectos eran nacionales y había 9 proyectos internacionales, 8 de ellos con financiación exclusiva procedente de la Comisión Europea, tanto del Sexto como del Séptimo Programa Marco. La Figura 5 muestra la distribución de los proyectos activos según el origen de la financiación. Otros privados 1 Otros públicos 2 Fundación Maphre 2 MICINN 7 Comisión Europea/Programa Marco/NIH 9 MSPS 13 Fundación Mutua Madrileña 53 ISCIII 64 0 10 20 30 40 50 60 70 Figura 5. Número de proyectos activos en 2009 según origen de la financiación. 12 El siguiente listado muestra la distribución del número de proyectos en función del servicio asistencial de procedencia del investigador principal: Alergia 4 Microbiología 1 Anatomía Patológica 4 Nefrología 2 Angiología y Cirugía Vascular 1 Neonatología 1 Aparato Digestivo 6 Neumología 2 Cardiología 11 Neurocirugía 2 Cardiología Intervencionista 5 Neurología 12 Cirugía General I 3 Obstetricia y Ginecología 2 Cirugía General II 2 Oftalmología 7 Cirugía Mayor Ambulatoria (CMA) 2 Oncología Médica 13 Cirugía Torácica 1 Psicología Clínica 1 Dirección Enfermería 1 Psiquiatria 13 Endocrinología 5 Radiodiagnóstico 2 Farmacología Clínica 1 Reumatología 4 Física Médica 4 Sala Blanca 1 Geriatria 1 Subdirección Enfermería 2 Inmunología 7 Traumatología y C. Ortopédica 4 Medicina Interna 2 UCM 2 Medicina Interna III 4 Unidad de Arritmias 1 Medicina Nuclear 1 Unidad de Ecocardiografía 5 Medicina Preventiva 4 Urgencias 1 10. Ensayos clínicos La FIBHCSC tenía registrados en el año 2009 un total de 550 ensayos clínicos activos, de los cuales el 47% habían comenzado en el año 2008 y el 10,5% en el mismo año 2009. 13 11. Listado de publicaciones del HCSC correspondientes al año 2009 1. Fernandez-Rivas, M. The place of lipid transfer proteins (LTP) in the cross -reactivity of plant foods. Rev. Fr. Allergol., 2009; 49(5):433-436. 2. Kummeling, I; Mills, ENC; Clausen, M; Dubakiene, R; Perez, CF; Fernandez-Rivas, M; Knulst, AC; Kowalski, ML; Lidholm, J; Le, TM; Metzler, C; Mustakov, T; Popov, T; Potts, J; van Ree, R; Sakellariou, A; Tondury, B; Tzannis, K; Burney, P. The EuroPrevall sur veys on the prevalence of food allergies in children and adults: background and study methodology. Allergy, 2009; 64(10):1493-1497. 3. del Rio, PR; Gonzalez-Gutierrez, ML; Sanchez-Lopez, J; Nunez-Acevedo, B; Alvarez, JMB; MartinezCocera, C. Urticaria Caused by Antihistamines: Report of 5 Cases. J. Invest. Allergol. Clin. Immunol., 2009; 19(4):317-320. 4. Schulten, V; Radakovics, A; Hartz, C; Mari, A; Vazquez-Cortes, S; Fernandez-Rivas, M; Lauer, I; JahnSchmid, B; Eiwegger, T; Scheurer, S; Bohle, B. Characteriza tion of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach. J. Allergy Clin. Immunol., 2009; 124(1):100-107. 5. Fernandez-Rivas, M; Fernandez, SG; Nadal, JA; de Durana, MDAD; Garcia, BE; Gonzalez-Mancebo, E; Martin, S; Barber, D; Rico, P; Tabar, AI. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy, 2009; 64(6):876 -883. 6. Rivas, MF. Food Allergy in Alergologica -2005. J. Invest. Allergol. Clin. Immunol., 2009; 19(Suppl. 2):37-44. 7. Serrano, P; Justicia, JL; Sanchez, C; Cimarra, M; Fernandez-Tavora, L; Orovitg, A; Moreno, C; Guerra, F; Alva, V. Systemic tolerability of specific subcutaneous immunotherapy with index -of-reactivitystandardized allergen extracts administered using clustered regimens: a retrospective, observational, multicenter study. Ann. Allergy Asthma Immunol., 2009; 102(3):247 -252. 8. de Arellano, IRR; Vazquez-Cortes, S; Sinaniotis, AC; Fernandez-Rivas, M. False Positive Placebo Reaction in a Double-Blind Placebo-Controlled Food Challenge [Editorial] J. Invest. Allergol. Clin. Immunol., 2009; 19(3):241-242. 9. Rodriguez-del Rio, P; Sanchez-Lopez, J; Robledo Echarren, T; Martinez-Cocera, C; Fernandez-Rivas, M. Selective allergy to Venus antiqua clam [Editorial] Allergy, 2009; 64(5):815-815. 10. Schulten, V; Radakovics, A; Hartz, C; Mari, A; Vazquez-Cortes, S; Fernandez-Rivas, M; Lauer, I; JahnSchmid, B; Eiwegger, T; Scheurer, S; Bohle, B. Characterisation of the allergic T cell response to Pru p 3, the nonspecific lipid transfer protein in peach. Allergy, 2009; 64(Suppl. 90):99-. 11. de Lema, BMG; Perez, MR; del Rio, PR; Echarren, TR; Gutierrez, MG; Cocera, CM. Feno and ECP as markers of bronchial inflammation in a population of grass pollen allergic patients. Allergy, 2009; 64(Suppl. 90):421-. 12. Fernandez-Rivas, M; Tolosa, LB; Vazquez-Cortes, S; Zayas, L; Rodriguez-Jimenez, B; Fernandez, C; Cocera, CM. Grass pollen allergy: factors associated with an asthma phenotype in patients from Spain. Allergy, 2009; 64(Suppl. 90):834-. 13. Hoffmann-Sommergruber, K; Sancho, A; Holzhauser, T; Lidholm, J; Marknell, DA; Skov, P; Alessandri, S; Lovegrove, A; Marsh, J; Neubauer, A; Lauer, I; Hofstetter, G; Radauer, C; Reese, G; FernandezRivas, M; Vieths, S; Shewry, P; Mills, C. Update on the Europrevall food allergen library: requirements for high quality allergens to improve in vitro diagnosis. Allergy, 2009; 64(Suppl. 90):931-. 14 14. Sifuentes, LG; Pastor, C; Acevedo, BN; Cortes, SV; Cocera, CM; Fernandez-Rivas, M. Life-threatening anaphylaxis in an adult patient monosensi tised to almond: a case report. Allergy, 2009; 64(Suppl. 90):943-. 15. del Rio, PR; Vazquez-Cortes, S; Tolosa, LB; de Arellano, IRR; Martinez-Cocera, C; Fernandez-Rivas, M. Factors related to positive outcome of double-blind placebo-controlled food challenges in egg allergic children. Allergy, 2009; 64(Suppl. 90):948-. 16. Perez, MR; Fernandez, CG; Marin, PR; de Arcaya, CVD. First description of contact dermatitis to eupatorium aromatizans, a compositae plant of the Dominican Republic. Allergy, 2009; 64(Suppl. 90):1036-. 17. Acevedo, BN; Tolosa, LB; Vazquez-Cortes, S; Martin, FC; Martin, MC; Sifuentes, LG; Cocera, CM; Fernandez-Rivas, M. Component resolved diagnosis of grass pollen allergic patients from Spain. Allergy, 2009; 64(Suppl. 90):1108-. 18. Rodriguez-Alvarez, M; Rivas, MF; Vazquez-Cortes, S; del Rio, PR; Zayas, L; Echarren, TR; Cocera, CM. Follow up of desensitised patients and immunological changes after specific oral tolerance induction to milk. Allergy, 2009; 64(Suppl. 90):1258 -. 19. Vazquez-Cortes, S; Escudero, SC; Acevedo, BN; Radauer, C; Zayas, L; Griesmeier, U; Breiteneder, H; Fernandez-Rivas, M. Diagnostic performance of an rGad c 1 and rCyp c 1 specific immunoassay. Allergy, 2009; 64(Suppl. 90):1322-. 20. Ruiz-Gimenez, L; Moreira, A; Rodriguez, R; Rubira, JG; Ferna ndez-Rivas, M. Kounis syndrome due to amoxicillin. Allergy, 2009; 64(Suppl. 90):1392-. 21. Fernandez-Rivas, M; Barreales, L; Fernandez, C; Rodriguez-Jimenez, B; Zayas, L; Cimarra, M; Martinez-Cocera, C. Factors Associated With The Presence Of Asthma In Grass P ollen Allergic Patients From Spain. J. Allergy Clin. Immunol., 2009; 123(2. Suppl. S):54 -. 22. Rodriguez-Alvarez, M; Rivas, MF; Echarren, TR; Cortes, SV; Martinez-Cocera, C. Prognostic Markers For Specific Oral Tolerance Induction (soti) To Milk. J. Allergy Cl in. Immunol., 2009; 123(2. Suppl. S):83-. 23. Asero, R; Fernandez-Rivas, M; Knulst, AC; Bruijnzeel -Koomen, CAFM. Double-blind, placebocontrolled food challenge in adults in everyday clinical practice: a reappraisal of their limitations and real indications. Curr. Opin. Allergy Clin. Immunol., 2009; 9(4):379-385. 24. Abasolo, D; Hornero, R; Espino, P. APPROXIMATE ENTROPY OF EEG BACKGROUND ACTIVITY IN ALZHEIMER'S DISEASE PATIENTS. Intell. Autom. Soft Comput., 2009; 15(4):591 -603. 25. Maestu, F; Campo, P; Garcia-Morales, I; del Barrio, A; Paul, N; del Pozo, F; Ortiz, T; Gil -Nagel, A. Biomagnetic profiles of verbal memory success in patients with mesial temporal lobe epilepsy. Epilepsy Behav., 2009; 16(3):527-533. 26. Garcia-Morales, I; Maestu, F; Perez-Jimenez, MA; Elices, E; Ortiz, T; Alvarez-Linera, J; Gil-Nagel, A. A clinical and magnetoencephalography study of MRI -negative startle epilepsy. Epilepsy Behav., 2009; 16(1):166-171. 27. Camafeita, E; Lamas, JR; Calvo, E; Lopez, JA; Fernandez-Gutierrez, B. Proteomics: New insights i nto rheumatic diseases. Proteom. Clin. Appl., 2009; 3(2):226 -241. 28. Bernal-Lopez, MR; Ripodas, A; Aragoncillo, P; Carbonell, A; Rufilanchas, JJ; Fernandez-Durango, R; Tinahones, FJ; Gomez-Huelgas, R; Fernandez-Cruz, A. Characterization and localization of the endothelin receptors in human end-stage heart failure ETA/ETB receptor system-Role in the failing human heart. Process Biochem., 2009; 44(6):661-667. 15 29. Varade, J; Lamas, JR; Fernandez-Arquero, M; Jover, JA; de la Concha, EG; Martinez, A; FernandezGutierrez, B; Urcelay, E. NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis. Nitric Oxide-Biol. Chem., 2009; 21(40271):171-174. 30. Ruiz, E; Redondo, S; Gordillo-Moscoso, A; Rodriguez, E; Reguillo, F; Martinez-Gonzalez, J; Tejerina, T. EPC adhesion to arteries from diabetic and non-diabetic patients: effect of pioglitazone. Front. Biosci., 2009; 14():3608-3618. 31. 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A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas. Oncogene, 2009; 28(26):2425-2435. 35. Campos-Mollo, E; Lopez-Garrido, MP; Blanco-Marchite, C; Garcia-Feijoo, J; Peralta, J; BelmonteMartinez, J; Ayuso, C; Escribano, J. CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability. Mol. Vis., 2009; 15(42):417 -431. 36. Cervigon, R; Moreno, J; Reilly, RB; Perez-Villacastin, J; Castells, F. Ventricular rhythm in atrial fibrillation under anaesthetic infusion with propofol. Physiol. Meas., 2009; 30(8):833-845. 37. Rosinol, L; Cibeira, MT; Martinez, J; Mateos, MV; Terol, MJ; de la Rubia, J; Palomera, L; de Arriba, F; Oriol, A; Alegre, A; Besalduch, J; de Paz, R; Garcia -Larana, J; Diaz-Mediavilla, J; Sureda, A; Lahuerta, JJ; Miguel, JS; Blade, J. 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Listado de proyectos competitivos del HCSC activos durante el año 2009 PROYECTOS COFINANCIADOS DENOMINACIÓN FINANCIADOR DOPPLER CIP: DETERMINING OPTIMAL NON-INVASIVE PARAMETERS FOR THE PREDICTION OF LEFT VENTRICULAR MOPHOLOGIC AND FUNCTIONAL REMODELING IN CHRONIC EU/PRG. MARCO ISCHEMIC PATIENTS EUHEART: PERSONALISED & INTEGRATED CARDIAC CARE: PATIENT-SPECIFIC CARDIOVASCULAR MODELLING AND SIMULATION FOR IN SILICO DISEASE UNDERSTANDING & MANAGEMENT AND FOR MEDICAL DEVICE EVALUATION & OPTIMIZATION EUROPREVALL: THE PREVALENCE, COST AND BASIS OF FOOD ALLERGY ACROSS EUROPE EVINCI: EVALUATION OF INTEGRATED CARDIAC IMAGING FOR THE DETECTION AND CHARACTERIZATION OF ISCHEMIC HEART DISEASE FAST: TOWARDS SAFE AND EFFECTIVE IMMUNOTHERAPY OF PERSISTENT LIFETHREATENING FOOD ALLERGIES HEARTCYCLE: COMPLIANCE AND EFFECTIVENESS IN HF AND CHD CLOSEDLOOP MANAGEMENT METABO: CONTROLLING CHRONIC DISEASES RELATED TO METABOLIC DISORDERS MYHEART: PERSONALISED & INTEGRATED CARDIAC CARE: PATIENT-SPECIFIC CARDIOVASCULAR MODELLING AND SIMULATION FOR IN SILICO DISEASE UNDERSTANDING & MANAGEMENT AND FOR MEDICAL DEVICE EVALUATION & OPTIMIZATION TRAIL TO REDUCE IDDM IN THE GENETICALLY AT RISK-STUDY TRIGR, PROJECT IP SERVICIO ZAMORANO GÓMEZ, JOSÉ LUIS UNIDAD DE ECOCARDIOGRAFÍA EU/PRG. MARCO PÉREZ VILLACASTÍN DOMÍNGUEZ, JULIÁN UNIDAD DE ECOCARDIOGRAFÍA EU/PRG. MARCO FERNÁNDEZ RIVAS, MARÍA MONTSERRAT ALERGIA EU/PRG. MARCO ZAMORANO GÓMEZ, JOSÉ LUIS UNIDAD DE ECOCARDIOGRAFÍA EU/PRG. MARCO FERNÁNDEZ RIVAS, MARÍA MONTSERRAT ALERGIA EU/PRG. MARCO PÉREZ VILLACASTÍN DOMÍNGUEZ, JULIÁN UNIDAD DE ARRITMIAS EU/PRG. MARCO CALLE PASCUAL, ALFONSO LUIS ENDOCRINOLOGÍA EU/PRG. MARCO PÉREZ VILLACASTÍN DOMÍNGUEZ, JULIÁN UNIDAD DE ECOCARDIOGRAFÍA EU/PRG. MARCO NIH SERRANO RÍOS, MANUEL MEDICINA INTERNA 52 PROYECTOS CON FINANCIACIÓN PÚBLICA DENOMINACIÓN ABORDAJE DE LAS ENFERMEDADES RESPIRATORIAS RARAS. COORDINACIÓN ENTRE NIVELES ASISTENCIALES CHILD TRAUMA NETWORK: PSYCHOLOGICAL NETWORK SUPPORT TO VIOLENCE TRAUMATIZED CHILDREN: DISASTERS, CONFLICTS ALTERACIONES EN LAS ZONAS ATENUADORAS DE LOS GENES DE RESISTENCIA A MACROLIDOS EN MOCRORGANISMOS GRAMPOSITIVOS IMPLICADOS EN INFECCIONES RESPIRATORIAS. RELACIÓN CON LOS PERFILES FENOTIPICOS. ANÁLISIS PROTEÓMICO DE LA EXPRESIÓN DE PROTEÍNAS DIFERENCIALES EN CÉLULAS MADRE MESENQUIMALES DE PACIENTES CON ARTROSIS Y EN SUJETOS SANOS. APLICACIÓN DE TERAPIAS REGENERATIVAS EN HUMANOS:CREACIÓN DE UNA SALA BLANCA CALIDAD ASISTENCIAL Y SEGURIDAD DE LOS PACIENTES CON ENFERMEDADES REUMÁTICAS: IMPLANTACIÓN DE UN SISTEMA DE EVENTOS ADVERSOS E REUMATOLOGÍA CARACTERIZACIÓN FUNCIONAL DE LA CONDUCTANCIA LUMINAL DE POTASIO EN LA MUCOSA COLINCA DE LOS MAMÍFEROS: NUEVOS ENFOQUES TERAPÉUTICOS PARA LA HIPERSECRECIÓN INTESTINAL. CARACTERIZACIÓN MOLECULAR DEL CÁNCER COLORRECTAL EN FAMILIAS AMSTERDAM NEGATIVAS PARA EL FENOTIPO MUTADOR (HNPCC-MSS) DESARROLLO DE LA GESTIÓN POR PROCESOS EN EL INSTITUTO DE PSIQUIATRÍA DEL HOSPITAL CLÍNICO SAN CARLOS DESARROLLO Y EVALUACIÓN DE NANOSISTEMAS DE AGENTES TERAPEUTICOS ANTIINFLAMATORIOS PARA EL TRATAMIENTO DEL SINDROME DE OJO SECO DESCRIPCIÓN DE INMUNOFENOTIPOS EN EL RECONOCIMIENTO INMUNOLÓGICO MEDIANTE UN ENSAYO MICROARRAY EN LA ALERGIA DE LECHE DE VACA EN POBLACIÓN INFANTIL PEDIÁTRICA. DETERMINACIÓN DEL MÉTODO MÁS FIABLE PARA LA EVALUACIÓN DE LA LIMPIEZA AUTOMÁTICA DEL INSTRUMENTAL QUIRÚRGICO Y EQUIPOS DE ANESTESIA. DISSECTION OF THE ALLERGIC RESPONSE TO FISH ALLERGENS IN THE SPANISH POPULATION: FROM THE ALLERGENS TO THE CLINICS. **ACCIÓN INTEGRADA 2006 EFECTOS DE UN PROGRAMA ASISTIDO DE EJERCICIO FÍSICO Y ADHERENCIA AL ESTILO DE VIDA MEDITERRANEA SOBRE EL CONTROL DE LOS FACTORES DE RIESGO CARDIOVASCULAR EN PACIENTES DIABÉTICOS TIPO 2 RECIEN DIAGNOSTICADOS. EFECTOS DE UN PROGRAMA DE INTERVENCIÓN NUTICIONAL Y DE ACTIVIDAD FÍSICA BASADO EN LA ADHERENCIA A UN NIVEL DE EXCELENCIA EN EL ESTILO DE VIDA MEDITERRANEO EN MUJERES CON ANTECEDENTES DE DIABETES GESTACIONAL. FINANCIADOR MSPS IP NIETO BARBERO, MARÍA ASUNCIÓN SERVICIO NEUMOLOGÍA ISCIII-MICINN LÓPEZ-IBOR ALIÑO, JUAN JOSÉ PSIQUIATRIA ISCIII-MICINN PICAZO DE LA GARZA, JUAN JOSÉ MICROBIOLOGÍA ISCIII-MICINN MARCO MARTÍNEZ, FERNANDO MICINN ISCIII-MICINN FERNÁNDEZ GUTIÉRREZ, BENJAMÍN JOVER JOVER, JUAN ÁNGEL TRAUMATOLOGÍA Y C. ORTOPÉDICA SALA BLANCA REUMATOLOGÍA ISCIII-MICINN MAYOL MARTÍNEZ, JULIO ÁNGEL CIRUGÍA GENERAL I ISCIII-MICINN CALDES LLOPIS, TRINIDAD MSPS LÓPEZ-IBOR ALIÑO, JUAN JOSÉ ONCOLOGÍA MÉDICA PSIQUIATRIA ISCIII-MICINN BENÍTEZ DEL CASTILLO SÁNCHEZ, JOSÉ MANUEL OFTALMOLOGÍA ISCIII-MICINN FERNÁNDEZ RIVAS, MARÍA MONTSERRAT ALERGIA ISCIII-MICINN FERERES CASTIEL, JOSÉ MICINN FERNÁNDEZ RIVAS, MARÍA MONTSERRAT MEDICINA PREVENTIVA ALERGIA MSPS CALLE PASCUAL, ALFONSO LUIS ENDOCRINOLOGÍA MSPS CALLE PASCUAL, ALFONSO LUIS ENDOCRINOLOGÍA 53 DENOMINACIÓN EFICACIA DE UN PROGRAMA DE GESTIÓN DE ENFERMEDADES EN PACIENTES DE EDAD MUY AVANZADA CON INSUFICIENCIA CARDIACA E IMPORTANTE COMORBILIDAD: ENSAYO MULTICÉNTRICO RANDOMIZADO. ELABORACIÓN DE UNA VÍA CLÍNICA PARA LA HEMORRAGIA SUBARACNOIDEA EN EL HOSPITAL CLÍNICO SAN CARLOS. MADRID ENFERMEDADES INFLAMATORIAS INTESTINALES: FARMACOGENÉTICA Y SUSCEPTIBILIDAD CONFERIDA POR GENES DE LA RUTA DE SEÑALIZACIÓN DEL IL-6. ENFERMEDADES MUSCULOESQUELÉTICAS FINANCIADOR ISCIII-MICINN IP RIBERA CASADO, JOSÉ MANUEL SERVICIO GERIATRIA MSPS MATÍAS GUIU GUIA, JORGE NEUROLOGÍA ISCIII-MICINN GÓMEZ DE LA CONCHA, EMILIO INMUNOLOGÍA ISCIII-MICINN FERNÁNDEZ GUTIÉRREZ, BENJAMÍN REUMATOLOGÍA ENSAYO CLÍNICO RANDOMIZADO DOBLE CIEGO DE CARBONATO DE LITIO COMO TERAPIA DE ASOCIACIÓN EN ESCLEROSIS LATERAL AMIOTRÓFICA ESTUDIO ALEATORIZADO Y CONTROLADO DE LA EFICACIA DE LA PSICOTERAPIA DINÁMICA BREVE EN PACIENTES CON TRASTORNOS DE LA PERSONALIDAD BORDELINE ESTUDIO DE ASOCIACIÓN DE VARIANTES DEL GEN QUE CODIFICA PARA LA SUBUNIDAD ALFA 7 DEL RECEPTOR NICOTÍNICO NEURONAL (CHRNA7) Y RASGOS FENOTÍPICOS COMUNES A TRASTORNO BIPOLAR Y ESQUIZOFRENIA ESTUDIO DE ASOCIACIÓN DE VARIANTES DEL GEN QUE CODIFICA PARA LA SUBUNIDAD ALFA 7 DEL RECEPTOR NICOTINICO NEURONAL (CHRNA7) Y RASGOS FENOTIPICOS COMUNES A TRANSTORNO BIPOLAR Y ESQUIZOFRENIA ESTUDIO DE CÉLULAS TUMORALES EN SANGRE PERIFÉRICA EN CÁNCER DE MAMA Y COLON. ESTUDIO DE SU VALOR PRONÓSTICO Y DE SU RELACIÓN CON TNM Y LA ENFERMEDAD METASTÁSICA ESTUDIO DE LA APOPTOSIS, ESTRÉS OXIDATIVO, Y RECEPTOR DE ENDOTELINA, ETB, EN EL GLAUCOMA DE ÁNGULO ABIERTO: SU POSIBLE RELACIÓN CON EL GRADO DEL DEFECTO DEL CAMPO VISUAL. ESTUDIO DE LA EFECTIVIDAD A LARGO PLAZO DEL TRATAMIENTO DE LA HEPATITIS CRÓNICA C EN PACIENTES COINFECTADOS POR VIH Y VHC ESTUDIO DE LA EFICACIA Y SEGURIDAD DE INYECCIONES INTRAVITREAS DE BEVACIZUMAB EN EL EDEMA MACULAR SECUNDARIO A OCLUSIONES VENOSAS RETINIANA (EBOVER) ESTUDIO DE LA ENFERMEDAD CORONARIA; EFECTIVIDAD Y OPTIMIZACION DEL TRATAMIENTO ESTUDIO DE LA RELACIÓN ENTRE EL TRAUMA INFANTIL Y LAS DIFUSIONES BIOLÓGICAS EN EL TRASTORNO LÍMITE DE LA PERSONALIDAD ESTUDIO DE UTILIZACIÓN DE ANTIFÚNGICOS SISTÉMICOS EN LOS HOSPITALES ESPAÑOLES ISCIII-MICINN GALÁN DÁVILA, LUCÍA NEUROLOGÍA ISCIII-MICINN RENESES PRIETO, BLANCA PSIQUIATRIA ISCIII-MICINN CABRANES DÍAZ, JOSÉ ANTONIO PSIQUIATRIA ISCIII-MICINN CABRANES DÍAZ, JOSÉ ANTONIO PSIQUIATRIA ISCIII-MICINN DÍAZ-RUBIO GARCÍA, EDUARDO ONCOLOGÍA MÉDICA ISCIII-MICINN FERNÁNDEZ DURANGO, FELISA RAQUEL OFTALMOLOGÍA ISCIII-MICINN TÉLLEZ MOLINA, MARÍA JESÚS ISCIII-MICINN DONATE LÓPEZ, JUAN MEDICINA INTERNA III OFTALMOLOGÍA MICINN ISCIII-MICINN PÉREZ VILLACASTÍN DOMÍNGUEZ, JULIÁN CARRASCO PERERA, JOSÉ LUIS CARDIOLOGÍA PSIQUIATRIA ISCIII-MICINN PORTOLÉS PÉREZ, ANTONIO ESTUDIO DEL MAPA PROTEÓMICO DEL PLASMA Y DE LAS PLAQUETAS DE PACIENTES RESISTENTES A LA ASPIRINA. ISCIII-MICINN LÓPEZ FARRÉ, ANTONIO FARMACOLOGÍA CLÍNICA CARDIOLOGÍA 54 DENOMINACIÓN ESTUDIO TRANSLACIONAL DE LA GENÉTICA DE LA ESCLEROSIS MÚLTIPLE. FINANCIADOR ISCIII-MICINN IP URCELAY GARCÍA, ELENA EVALUACIÓN DE LA EFICACIA Y SEGURIDAD DE LA INYECCCIÓN INTRAVÍTREA DE BEVACIZUMAB EN EL TRATAMIENTO DE LA NEOVASCULARIZACIÓN COROIDEA ASOCIADA A LA MIOPÍA MAGNA EVALUACIÓN DE LA EFICACIA Y SEGURIDAD DE LA INYECCIÓN INTRAVITREA DE TRIAMCINOLONA EN EL TRATAMIENTO DEL EDEMA DE MACULA DEL DIABÉTICO. EVALUACIÓN IN VIVO DEL PAPEL DE LA INTERLEUQUINA 6 Y DEL CORTISOL EN LA VARIACIÓN CIRCADIANA DE LOS EVENTOS FATALES (INFARTO DE MIOCARDIO, MUERTE SÚBITA, ANGINA INESTABLE) FARMACOGENÉTICA DEL INTERFERON BETA EN PACIENTES ESPAÑOLES DE ESCLEROSIS MÚLTIPLE ISCIII-MICINN DONATE LÓPEZ, JUAN SERVICIO APARATO DIGESTIVO OFTALMOLOGÍA ISCIII-MICINN DONATE LÓPEZ, JUAN OFTALMOLOGÍA ISCIII-MICINN MACAYA MIGUEL, CARLOS CARDIOLOGÍA ISCIII-MICINN INMUNOLOGÍA GENÓMICA DEL CÁNCER. PROYECTO COOPERATIVO RED DE CENTROS DE CÁNCER. SUBPRYECTO NODO DEL HOSPITAL CLÍNICO SAN CARLOS. IDENTIFICACIÓN DE BIOMARCADORES PROTEICOS ASOCIADOS A RESISTENCIA A LA ASPIRINA Y A TIENOPIRIDINAS EN PACIENTES CON CARDIOPATIA ISQUÉMICA ESTABLECIDA. (ESTUDIO BIRAT) ISCIII-MICINN FERNÁNDEZ ARQUERO, MIGUEL MARTÍNEZ DONCEL, ALFONSO DÍAZ-RUBIO GARCÍA, EDUARDO ISCIII-MICINN MACAYA MIGUEL, CARLOS ONCOLOGÍA MÉDICA CARDIOLOGÍA INTERVENCIONIST A IDENTIFICACIÓN Y SEGURIDAD INTEGRAL DE PACIENTES EN UN HOSPITAL DE MEDIA -LARGA ESTANCIA IMPORTANCIA DE LAS INTERACCIONES ENTRE GENES IMPLICADOS EN RESPUESTA INFLAMATORIA EN LA SUSCEPTIBILIDAD A ENFERMEDAD CELÍACA. INCREMENTO DEL NÚMERO DE CORAZONES VÁLIDOS PARA TRASPLANTE TRAS SU RECUPERACIÓN Y EVALUACIÓN EX_VIVO UTILIZANDO UN NUEVO MÉTODO DE PRESERVACIÓN. MSPS ISCIII-MICINN NÚÑEZ PARDO DE VERA, MARÍA CONCEPCIÓN INMUNOLOGÍA ISCIII-MICINN NÚÑEZ PEÑA, JOSÉ RAMÓN INFLUENCIA DE LA CIRUGÍA CARDIACA PRECOZ EN EL PRONÓSTICO A CORTO Y LARGO PLAZO DE LA ENDOCARDITIS I NFECCIOSA. ENDOVAL -1. INMUNIDAD INNATA, INFECCIÓN POR HHV-6 Y GENÉTICA EN LA PROGRESIÓN DE LA DISCAPACIDAD EN PACIENTES CON ESCLEROSIS MÚLTIPLE INMUNOGENÉTICA AVANZADA DE LA ESCLEROSIS MÚLTPLE EN LA POBLACIÓN ESPAÑOLA. ISCIII-MICINN VILA COSTA, ISIDRE CIRUGÍA MAYOR AMBULATORIA (CMA) CARDIOLOGÍA ISCIII-MICINN ÁLVAREZ LAFUENTE, ROBERTO NEUROLOGÍA ISCIII-MICINN MARTÍNEZ DONCEL, ALFONSO INMUNOLOGÍA INTERVENCIÓN EDUCATIVA EN EL PACIENTE HIPERTENSO CON TRATAMIENTO FARMACOLÓGICO. MSPS SAINZ MARTÍN, MARÍA LINEA DE ESTABILIZACIÓN ISCIII-MICINN GÓMEZ GARRE, DULCENOMBRE LOCALIZACIÓN DE LOS DIFERENTES GENES DE SUSCEPTIBLIDAD PARA LA DEFICIENCIA DE IGA: REGIONES HLA Y NO HLA. ISCIII-MICINN FERNÁNDEZ ARQUERO, MIGUEL MEDICINA PREVENTIVA MEDICINA INTERNA III INMUNOLOGÍA 55 DENOMINACIÓN MARCADORES BIOLÓGICOS DE RESPUESTA A INTERFERÓN BETA EN PACIENTES CON ESCLEROSIS MÚLTIPLE Y SU RELACIÓN CON LOS NIVELES DE EXPRESIÓN Y DISPONIBILIDAD DEL RECEPTOR DEL HERPES VIRUS HUMANO-6 (CD46) MEJORA DE LA CALIDAD DE VIDA MEDIANTE LA MANIPULACIÓN QUIRÚRGICA DE LA ÓPTICA OCULAR MODULACIÓN DE LA RESPUESTA INMUNE MEDIANTE LA EXPRESIÓN DE HLA-G Y CD1D EN CÉLULAS MADRE CD133 POSITIVAS DE CORDÓN UMBILICAL Y SU UTILIDAD EN TERAPIA CELULAR Y MEDICINA REGENERATIVA. OTR.RADIOLOGICAL PROTECTION IN INTERVENTIONAL RADIOLOGY FINANCIADOR ISCIII-MICINN IP ARROYO GONZÁLEZ, RAFAEL VÍCTOR SERVICIO NEUROLOGÍA ISCIII-MICINN IRADIER URRUTIA, MARÍA TERESA OFTALMOLOGÍA ISCIII-MICINN MARTÍNEZ LASO, JORGE MAURICIO UCM MICINN VAÑÓ CARRUANA, ELISEO FÍSICA MÉDICA PAPEL DE LAS CÉLULAS MONONUCLEADAS EN EL SÍNDROME DE RESISTENCIA A ASPIRINA EN PACIENTES CON CARDIOPATÍA ISQUÉMICA ESTABLECIDA. ISCIII-MICINN LÓPEZ FARRÉ, ANTONIO PARTICIPACIÓN DEL COLESTEROL EN LA FISIOPATOLOGÍA DE LA INSUFICIENCIA CARDICA. BÚSQUEDA DE NUEVOS ABORDAJES TERAPEÚTICOS PATOLOGÍAS OCULARES CAUSANTES DE CEGUERA LIGADAS AL ENVEJECIMIENTO PATRÓN NECROSCÓPICO Y CLÍNICO DE LA MUERTE SÚBITA. PROYECTO ENMARCADO EN LA RED TEMÁTICA: CARACTERÍSTICAS EPIDEMIOLÓGICAS, CLÍNICAS Y ANATOMAPTOLÓGICAS DE LA MUERTE SÚBITA EN ESPAÑA (G03/078) PATRONES DE CARRERA, EVALUACIÓN DEL POTENCIAL DE INSERCIÓN LABORAL E INFLUENCIA EN LA CONSECUCIÓN DE EMPLEO PERCEPCIÓN DE CARAS EMOCIONALMENTE NEUTRAS EN PSICOSIS TEMPRANAS: ESTUDIO MAGNETOENCEFALOGRÁFICO DE PACIENTES MUY DELIRANTES VERSUS POCO DELIRANTES. PERFIL ESTEROIDEO EN DEPORTISTAS Y SU RELACIÓN CON PARAMETROS FISIOLOGICOS Y GENETICOS. DESARROLLO DE MODELOS MATEMATICOS PARA LA DETERMINACIÓN DE NIVELES UMBRALES DE ESTEROIDES EN CONTROL DE DOPAJE PERSONALIDAD Y MECANISMOS DE RESPUESTA AL ESTRÉS EN LAS MANIFESTACIONES CLÍNICAS DE LOS TRASTORNOS DE LA CONDUCTA ALIMENTARIA. PREDICCIÓN DE LA RESPUESTA AL TRATAMIENTO CON DOXORUBICINA O DOCETAXEL EN CÁNCER DE MAMA MEDIANTE MODELOS PRONÓSTICOS UNIGÉNICOS Y POLIGÉNICOS. PROGRAMA DE ATENCIÓN PSIQUIATRICA DIRIGIDA A ENFERMOS MENTALES SIN HOGAR DE MADRID. PROGRAMA DE DEFINICIÓN DIAGNÓSTICA DEL TRASTORNO POR DEFICIT DE ATENCIÓN E HIPERACTIVDAD EN LA COMUNIDAD DE MADRID. PROGRAMA DE MEJORA DE LA COMUNICACIÓN ENTRE EL PERSONAL SANITARIO Y LA PACIENTE OBSTÉTRICA Y SUS FAMILIARES. ATENCIÓN INTEGRAL EN COMUNICACIÓN DESDE URGENCIAS HASTA EL ALTA A DOMICILIO ISCIII-MICINN GÓMEZ GARRE, DULCENOMBRE ISCIII-MICINN ISCIII-MICINN GARCÍA FEIJOÓ, JULIÁN MACAYA MIGUEL, CARLOS CARDIOLOGÍA INTERVENCIONIST A MEDICINA INTERNA III OFTALMOLOGÍA CARDIOLOGÍA ISCIII-MICINN ALONSO GARCÍA, MIGUEL ISCIII-MICINN LÓPEZ-IBOR ALIÑO, JUAN JOSÉ MICINN FERNÁNDEZ PÉREZ, CRI STINA MEDICINA PREVENTIVA ISCIII-MICINN DÍAZ MARSÁ, MARINA FRANCISCA PSIQUIATRIA ISCIII-MICINN MARTÍN JIMÉNEZ, MIGUEL MSPS CRESPO HERVÁS, DOLORES ONCOLOGÍA MÉDICA PSIQUIATRIA MSPS ORTIZ ALONSO, TOMÁS PSIQUIATRIA MSPS MAÑAS RUEDA, CRISTINA ONCOLOGÍA MÉDICA PSICOLOGÍA CLÍNICA PSIQUIATRIA 56 DENOMINACIÓN PROGRAMA DE MEJORA DE LA COMUNICACIÓN ENTRE EL PERSONAL SANITARIO Y LA PACIENTE OBSTÉTRICA Y SUS FAMILIARES. ATENCIÓN INTEGRAL EN COMUNICACIÓN DESDE URGENCIAS HASTA EL ALTA A DOMICILIO. PROGRAMA DE PREVENCIÓN DE CAIDAS EN EL ÁMBITO HOSPITALARIO FINANCIADOR MSPS IP FRANCISCO GARCÍA GARCÍA SERVICIO SUBDIRECCIÓN ENFERMERÍA MSPS FERNANDEZ DEL PALACIO, ENCARNACION PROGRAMA DE PSICOEDUCACIÓN A FAMILIARES DE ENFERMOS ESQUIZOFRÉNICOS Y APOYO A PACIENTES CON POCA ADHERENCIA AL TRATAMIENTO. PROTECCIÓN RADIOLÓGICA EN RADIOLOGÍA INTERVENCIONISTA (PRORARI) MSPS FRANCISCO GARCÍA GARCÍA ISCIII-MICINN VAÑÓ CARRUANA, ELISEO DIRECCIÓN ENFERMERÍA SUBDIRECCIÓN ENFERMERÍA FÍSICA MÉDICA PROTECCIÓN RADIOLÓGICA EN RADIOLOGÍA INTERVENCIONISTA MICINN VAÑÓ CARRUANA, ELISEO FÍSICA MÉDICA RED DE INVESTIGACIÓN EN INFLAMACIÓN Y ENFERMEDADES REUMÁTICAS ISCIII-MICINN FERNÁNDEZ GUTIÉRREZ, BENJAMÍN RED DE INVESTIGACIÓN EN INSUFICIENCIA CARDIACA EN ESPAÑA. REDINSCOR RED ESPAÑOLA DE ESCLEROSIS MÚLTIPLE RED HERACLES: DETERMINANTES GENÉTICOS Y AMBIENTALES DE LA DISFUNCIÓN VASCULAR. ISCIII-MICINN ISCIII-MICINN ISCIII-MICINN PÉREZ VILLACASTÍN DOMÍNGUEZ, JULIÁN GÓMEZ DE LA CONCHA, EMILIO LÓPEZ FARRÉ, ANTONIO TRAUMATOLOGÍA Y C. ORTOPÉDICA CARDIOLOGÍA INMUNOLOGÍA CARDIOLOGÍA RED TEMÁTICA DE INVESTIGACIÓN COOPERATIVA DE CANCER (RTICC): TRANSNACIONAL PLATAFORMA DE SERVICIO DE DETERMINACIÓN DE CÉLULAS TUMORALES CIRCULANTES EN CÁNCER COLORRECTAL ESTADIO III" REDINSCOR RED DE INVESTIGACIÓN DE INSUFICIENCIA CARDIACA EN ESPAÑA REGULACIÓN DE LA RESPUESTA INMUNE DE DIFERENTES SUBTIPOS DE CÉLULAS DENDRITICAS MEDIADAS POR CÉLULAS NKT MEDIANTE LA SOBRE EXPRESION DE CE1D EN SANGRE PERIFÉRICA Y DE CORDON UMBILICAL Y SU APLICACIÓN AL DISEÑO DE VACUNAS. RELACIÓN DEL ESTRÉS PSICOFÍSICO PREVIO COMO FACTOR DE RIESGO DE ICTUS ISCIII-MICINN DÍAZ-RUBIO GARCÍA, EDUARDO ONCOLOGÍA MÉDICA ISCIII-MICINN ISCIII-MICINN FERNÁNDEZ-CRUZ PÉREZ, ARTURO MARTÍNEZ LASO, JORGE MAURICIO CARDIOLOGÍA UCM ISCIII-MICINN CASTILLO PLA, OLGA NEUROLOGÍA RENEVAS RETICS DE BIOBANCOS ISCIII-MICINN ISCIII-MICINN EGIDO HERRERO, JOSÉ ANTONIO SANZ ORTEGA, JULIÁN RETICS DE INNOVACIONES EN TECNOLOGIAS MEDICAS Y SANITARIAS SISTEMA DE AUDITORÍA CONTROL DE CALIDAD Y DOSIMETRÍA A LOS PACIENTES A TIEMPO REAL PARA RADIOLOGÍA DIGITAL. TRATAMIENTO DE LAS LESIONES DEL MANGUITO ROTADOR MEDIANTE EL TRASPLANTE AUTÓLOGO DE CÉLULAS MADRE MESENQUIMALES DE ASPIRADOS DE MÉDULA ÓSEA UTILIDAD DE LA TOMOGRAFÍA POR EMISIÓN DE POSITRONES (PET) CON 18F-FDG Y DE LA PET-TAC EN LA EVALUACIÓN DE LA RESPUESTA AL TRATAMIENTO DE LA ENFERMEDAD DE HODGKIN Y LOS LINFOMAS DE HODKIN. VARIABILIDAD DE LA EXPRESIÓN DEL GEN BRCA1 Y RIES GO DE CÁNCER DE MAMA EN LA POBLACIÓN ESPAÑOLA. ISCIII-MICINN CAM MAYOL MARTÍNEZ, JULIO ÁNGEL VAÑÓ CARRUANA, ELISEO NEUROLOGÍA ANATOMÍA PATOLÓGICA CIRUGÍA GENERAL I FÍSICA MÉDICA ISCIII-MICINN FERNÁNDEZ GUTIÉRREZ, BENJAMÍN REUMATOLOGÍA ISCIII-MICINN CARRERAS DELGADO, JOSÉ LUÍS MEDICINA NUCLEAR ISCIII-MICINN DE LA HOYA MANTECÓN, MIGUEL ONCOLOGÍA MÉDICA 57 PROYECTOS CON FINANCIACIÓN PRIVADA DENOMINACIÓN FACTORES GENÉTICOS EN LA SUSCEPTIBILIDAD, EVOLUCIÓN Y RESPUESTA A FÁRMACOS EN PACIENTES ESPAÑOLES DE ARTRITIS REUMATOIDE. DIAGNÓSTICO EL RECHAZO AGUDO DEL TRASPLANTE RENAL PROCEDENTE DE DONANTE EN ASISTOLIA MEDIANTE ANÁLISIS PROTEÓMICO DE LA ORINA. CD46, RECEPTOR CELULAR DEL HERPESVIRUS HUMANO 6, Y RESPUESTA AL TRATAMIENTO CON INTERFERÓN BETA, EN PACIENTES CON ESCELEROSIS MÚLTIPLE PATRONES DE EXPRESIÓN DEL GEN BRCA1 QUE PUEDEN CONFERIR MAYOR RIESGO DE CANCER EN FAMILIAS CON SINDROME MAMA/OVARIO HEREDITARIO. ESTUDIO DE FACTORES, PRONÓSTICO EN PACIENTES CON CARCINOMA BRONCOGENICO NO MICROCITICO INTEVENIDOS QUIRURGICAMENTE. CARACTERIZACIÓN MOLECULAR MEDIANTE TISSUE-ARRAY DE SUBGRUPOS BIOLÓGICOS CON AFECTACIÓN GANGLIONAR FRENTA A PACIENTES SIN AFECTACIÓN GANGLIONAR. ESTUDIO ALEATORIZADO PARA COMPRAR 75MG/DÍA VERSUS 150MG/DÍA DE CLOPIDOGREL EN PACIENTES DIABÉTICOS CON ENFERMEDAD CORONARIA. EFECTOS FUNCIONALES PRECOCES DEL PRECONDICIONAMIENTO ISQUEMICO EN EL AUTOTRASPLANTE SEGMENTARIO DE INTESTINO EN EL CERDO. DESARROLLO DEL PROTEOMA DE LA PARED ARTERIAL DE PACIENTES ARTERIOESCLERÓTICOS CON DIABETES MELLITUS: INFLUENCIA DE LAS PLAQUETAS. MODIFICACION FARMACOLÓGICA DE LA FIBRILACIÓN VENTRICULAR MEDIANTE CROMAKALINA Y CLORURO DE BARIO PARA LOCALIZAR EL ORIGEN DE POSIBLES ROTORES MADRE ESTUDIO GENÓMICO Y PROTEÓMICO DEL TEJIDO ADIPOSO EN PATOLOGÍAS RELACIONADAS CON SÍNDROME METABÓLICO: OBESIDAD, DIABETES MELLITUS TIPO 2 Y SÍNDROME DE RESISTENCIA A LA INSULINA (SÍNDROME METABÓLICO). IDENTIFICACIÓN DE NUEVOS MARCADORES TUMORALES DE CANCER DE OVARIO. FINANCIADOR FMM IP GÓMEZ DE LA CONCHA, EMILIO SERVICIO INMUNOLOGÍA FMM MARQUES VIDAS, MARÍA SAN MIGUEL NEFROLOGÍA FMM ARROYO GONZÁLEZ, RAFAEL VÍCTOR NEUROLOGÍA FMM CALDES LLOPIS, TRINIDAD ONCOLOGÍA MÉDICA FMM GÓMEZ MARTÍNEZ, ANA MARÍA CIRUGÍA TORÁCICA FMM MACAYA MIGUEL, CARLOS CARDIOLOGÍA FMM MAYOL MARTÍNEZ, JULIO ÁNGEL CIRUGÍA GENERAL I FMM MOÑUX DUCAJÚ, GUILLERMO FMM PÉREZ VILLACASTÍN DOMÍNGUEZ, JULIÁN FMM SERRANO RÍOS, MANUEL CARDIOLOGÍA INTERVENCIONISTA UNIDAD DE ECOCARDIOGRAFÍA MEDICINA INTERNA FMM VIDART ARAGÓN, JOSÉ ANTONIO ESTUDIO DE ASOCIACIÓN DE VARIANTES DEL GEN QUE CODIFICA PARA LA SUBUNIDAD ALFA 7 DEL RECEPTOR NICOTÍNICO NEURONAL (CHRNA7) Y RASGOS FENOTÍPICOS COMUNES A TRASTORNO BIPOLAR Y ESQUIZOFRENIA ANÁLISIS DE LOS PERFILES DE MICRORNAS (MIRNAS) Y SU COMBINACIÓN CON LOS RESULTADOS DE EXPRESIÓN MASIVA DE MRNAS EN CÁNCER DE COLON PARA LA CLASIFICACIÓN DE ENFERMOS. *POSIBLE COINCIDENCIA CON COD.CEIC: B-07/104 Nº REG. 1079* CALIBRACIÓN INTRAOPERATIVA DE LA FUNDUPLICATURA LAPAROSCOPICA: RESULTADOS TRAS UTILIZACIÓN DE BUJIA INTRALUMNINAL Y TRAS MONITORIZACIÓN CON MANOMETRÍA DE ALTA RESOLUCIÓN FMM CABRANES DÍAZ, JOSÉ ANTONIO OBSTETRICIA Y GINECOLOGÍA PSIQUIATRIA FMM DÍAZ-RUBIO GARCÍA, EDUARDO ONCOLOGÍA MÉDICA FMM PÉREZ AGUIRRE, MARÍA ELIA CIRUGÍA GENERAL II 58 DENOMINACIÓN ANÁLISIS DE LA EXPRESIÓN DEL TGF-B Y SUS RECEPTORES (TBRI, TBRII, TBRIII) EN CÉLULAS MADRE MESENQUIMALES (MSCS) DE PACIENTES CON ARTROSIS. PERFIL DE LOS GENES Y PROTEÍNAS EXPRESADOS DIFERENCIALMENTE EN MSCS ESTIMULADAS CON TGF-B UTILIZANDO MICROARRAYS DE DNA DE GENOMA COMPLETO Y ELECTROFORESIS 2D -DIGE. IDENTIFICACIÓN Y CARACTERIZACIÓN DE LA SUBPOBLACIÓN DE CÉLULAS TRONCALES TUMORALES EN LOS GLIOMAS CEREBRALES HUMANOS: RELACIÓN CON LAS CÉLULAS TRONCALES NEURALES ESTUDIO DE POLIMORFISMOS DE LOS GENES QUE CODIFICAN PARA LA ALFA-1 ANTIQUIMOTRIPSINA, EL PROMOTOR DEL TRANSPORTADOR DE SEROTONINA, EL RECEPTOR NICOTÍNICO Y ALFA 7 Y APOLIPOPROTEÍNA COMO FACTORES DE RIESGO DE DESARROLLO DE DETERIORO GOGNITIVO LIGERO Y ENFERMEDAD DEL ALZHEIMER VALOR PRONÓSTICO Y UTILIDAD COMO MEDIDOR DE RESPUESTA ANTITUMORAL, TRAS TRATAMIENTO DE QUIMIOTERAPIA DE LAS CÉLULAS TUMORALES CIRCULANTES, DE LA EXPRESIÓN HER2/NEU Y DE LAS CÉLULAS ENDOTELIALES CIRCULANTES EN CÁNCER DE MAMA METASTÁSICO RASGOS DE SATURACIÓN DE OXIGENO DE LA HEMOGLOBINA Y SU RELACIÓN CON CÉLULAS PROGENITORES ENDOTELIALES Y FACTORES ANGIOGÉNICOS REGUALDORES DE LA VASCULARIZACIÓN RETINIANA EN NIÑOS PREMATUROS DE MENOS DE 28 SEMANAS Y EN UN MODELO EXPERIMENTAL DE RETINOPATÍA. INCREMENTO DEL NÚMERO DE CORAZONES VÁLIDOS PARA TRASPLANTE TRAS SU RECUPERACIÓN Y EVALUACIÓN EX_VIVO UTILIZANDO UN NUEVO MÉTODO DE PRESERVACIÓN. VALORACIÓN DE LA EFICACIA DEL PET-TAC 18 FDG EN EL DIAGNÓSTICO PRECOZ DE CÁNCER DE MAMA Y/U OVARICO EN MUJERES PORTADORAS DE MUTACIONES EN LOS GENES BRCA1 Y 2 ACTIVIDAD Y EXPRESIÓN DE 11-BETA-HIDROXI-ESTEROIDE DEHIDROGENASA 1 EN TEJIDO HEPÁTICO Y ADIPOSO (SUBCUTÁNEO Y VISCERAL) DE PACIENTES CON OBESIDAD MÓRBIDA Y SU RELACIÓN CON EL SÍNDROME METABÓLICO VALORACIÓN INTEGRAL DE LA ABLACIÓN DE LA MUCOSA ECTÓPICA DEL ESÓFAGO DE BARETT MEDIANTE RADIOFRECUENCIA BIPOLAR CARACTERIZACIÓN MOLECULAR MEDIANTE TISSUE-ARRAYS DE MENGIOMAS: CORRELACIÓN CON PARÁMETROS HISTOPATOLÓGICOS, RESUPUESTA AL TRATAMIENTO, RECIDIVA Y SUPERVIVENCIA. ESTUDIO TRANSLACIONAL DE LA GENÉTICA DE LAS ENFERMEDADES INFLAMATORIAS INTESTINALES ADAPTACIÓN Y VALIDACIÓN DE UN CUESTIONARIO PARA EVALUAR LA SEVERIDAD DEL SÍNDROME DE INTESTINO IRRITABLE EN PACIENTES ESPAÑOLES POLIMORFISMOS DE LA ESFINGOMIELIANASA NEUTRA TIPO 2 COMO FACTOR PREDICTOR DEL DESARROLLO DE HIPERTENSIÓN ARTERIAL PULMONAR EN LOS PACIENTES CON UNA ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA. REACTIVACIÓN RETROVIRAL POR HERPESVIRUS: IMPLICACIÓN EN ESCLEROSIS MÚLTIPLE FINANCIADOR FMM IP MARCO MARTÍNEZ, FERNANDO SERVICIO TRAUMATOLOGÍA Y C. ORTOPÉDICA FMM ZIMMAN MANSFELD, HORACIO MARIO NEUROCIRUGÍA FMM MARCOS DOLADO, ALBERTO NEUROLOGÍA FMM MARTÍN JIMÉNEZ, MIGUEL ONCOLOGÍA MÉDICA FMM MORO SERRANO, MANUEL NEONATOLOGÍA FMM NÚÑEZ PEÑA, JOSÉ RAMÓN FMM PÉREZ SEGURA, PEDRO CIRUGÍA MAYOR AMBULATORIA (CMA) ONCOLOGÍA MÉDICA FMM RUBIO HERRERA, MIGUEL ÁNGEL ENDOCRINOLOGÍA FMM RUIZ DE LEÓN SAN JUAN, ANTONIO APARATO DIGESTIVO FMM SANZ ORTEGA, JULIÁN FMM URCELAY GARCÍA, ELENA ANATOMÍA PATOLÓGICA APARATO DIGESTIVO FMM ALMANSA MENCHERO, MARÍA CRISTINA APARATO DIGESTIVO FMM ÁLVAREZ-SALA WALTHER, JOSÉ LUIS NEUMOLOGÍA FMM ARROYO GONZÁLEZ, RAFAEL VÍCTOR NEUROLOGÍA 59 DENOMINACIÓN ELECCIÓN DE LA DIANA ÓPTIMA PARA NEUROESTIMULACIÓN EN LOS TRASTORNOS AFECTIVOS. MAMOGRAFÍA DIGITAL DE CAMPO COMPLETO (MDCC). AVANCES EN LA DETECCIÓN Y VALORACIÓN DIAGNÓSTICA DE LAS MICROCALCIFICACIONES MAMARIAS. NUEVOS SIGNOS RADIOLÓGICOS Y CORRELACIÓN ANATOMO-PATOLÓGICA. ESTUDIO EPIDEMIOLÓGICO NACIONAL DEL DOLOR TORÁCICO NO CARDÍACO FINANCIADOR FMM FMM IP BARCIA ALBACAR, JUAN ANTONIO CEPEDA IZQUIERDO, Mª TERESA SERVICIO NEUROCIRUGÍA RADIODIAGNÓSTICO FMM DÍAZ-RUBIO GARCÍA, MANUEL APARATO DIGESTIVO ASPECTOS PROTEÓMICOS Y GENÉTICOS DE LA RESISTENCIA A LA ASPIRINA EN PACIENTES CON CARDIOPATÍA ISQUÉMICA ESTABLECIDA: IMPORTANCIA DE LOS LEUCOCITOS SOBRE ESTE SÍNDROME. FACTORES PRONÓSTICOS EN LA COLECISTITIS AGUDA. FMM LÓPEZ FARRÉ, ANTONIO CARDIOLOGÍA FMM GONZÁLEZ ARMENGOL, JUAN JORGE URGENCIAS VULNERABILIDAD SELECTIVA DE LA MOTONEURONA A LOS EFECTOS NEUROTÓXICOS DEL LÍQUIDO CEFALORRAQUÍDEO DE PACIENTES DE ESCLEROSIS LATERAL AMIOTRÓFICA (ELA) HAPLOTIPOS YIN-YANG EN GENES SUPRESORES DE TUMOR Y SUSCEPTIBILIDAD AL CÁNCER; EL GEN BRCA1 COMO MODELO. VALORACIÓN DE LA SEGURIDAD Y EFICACIA DE LA INYECCIÓN TRANSENDOCÁRDICA DE CÉLULAS PROGENITORAS ENDOTELIALES AUTÓLOGAS CD 133 PARA ANGIOGÉNESIS TERAPÉUTICA PREDICCIÓN EVOLUTIVA EN FASES PRECOCES DE LA HEPATITIS CRÓNICA POR VIRUS DE LA HEPATITIS C MEDIANTE LA IDENTIFICACIÓN DE MARCADORES MOLECULARES EN EL PROTEOMA PLASMÁTICO Y LINFOCITARIO Y SU RELACIÓN CON LAS ALTERACIONES HISTOLÓGICAS HEPÁTICAS DÉFICIT COGNITIVOS E IDEAS SOBREVALORADAS EN EL TRASTORNO OBSESIVO-COMPULSIVO Y EN LA ESQUIZOFRENIA. ESTUDIO DE NEUROIMAGEN FUNCIONAL CON MAGNETOENCEFALOGRAFÍA. VALORACIÓN DE LA FUNCIÓN PLAQUETARIA EN PACIENTES CON DISCINESIA VENTRICULAR IZQUIERDA TRANSITORIA (TAKOTSUBO) MORBI-MORTALIDAD Y CARACTERIZACIÓN GENOTÍPICA EN EL ÁMBITO RURAL Y URBANO DE LA PROVINCIA DE SEGOVIA. BYPASS DUODENO-ILEAL PROXIMAL TÉRMINO-LATERAL-CRUCE DUODENAL E ASA. COMO TRATAMIENTO DE LA DIABETES MELLITUS TIPO 2 ESTUDIO DEL MAPA PROTEÓMICO TISULAR Y EL PERFIL INMUNOHISTOQUÍMICO DEL CARCINOMA UROTELIAL VESICAL SUPERFICIAL VS INFILTRANTE. ESTUDIO DEL ESPECTRO PROTEICO MEDIANTE ESPECTROMETRÍA DE MASAS EN EL CÁNCER DE OVARIO. UTILIDAD DEL SEGUIMIENTO ECOCARDIOGRÁFICO TRIDIMENSI ONAL DEL MIOCARDIO Y DE LA RESONANCIA MAGNÉTICA CARDIACA EN LA CARACTERIZACIÓN Y DETECCIÓN PRECOZ DE PACIENTES CON MIOCARDIOPATÍA HIPERTRÓFICA. POLIMORFISMOS GENÉTICOS DE UGT1A9 Y MPR2: PAPEL EN LA FARMACOCINETICA Y EFECTOS SECUNDARIOS DE ACIDO MICOFENOLICO EN TRASPLANTE RENAL FMM MATÍAS GUIU GUIA, JORGE NEUROLOGÍA FMM DE LA HOYA MANTECÓN, MIGUEL ONCOLOGÍA MÉDICA FMM JIMÉNEZ QUEVEDO, PILAR FMM LADERO QUESADA, JOSÉ MARÍA CARDIOLOGÍA INTERVENCIONISTA APARATO DIGESTIVO FMM LÓPEZ-IBOR ALCOCER, MARÍA INÉS PSIQUIATRIA FMM NÚÑEZ GIL, IVÁN JAVIER CARDIOLOGÍA FMM FERNÁNDEZ PÉREZ, CRISTINA MEDICINA PREVENTIVA FMM SÁNCHEZ PERNAUTE, ANDRÉS CIRUGÍA GENERAL II FMM SANZ ORTEGA, JULIÁN FMM VIDART ARAGÓN, JOSÉ ANTONIO FMM ZAMORANO GÓMEZ, JOSÉ LUIS ANATOMÍA PATOLÓGICA OBSTETRICIA Y GINECOLOGÍA CARDIOLOGÍA INTERVENCIONISTA FMM SÁNCHEZ FRUCTUOSO, ANA ISABEL NEFROLOGÍA 60 DENOMINACIÓN RESPUESTA INMUNE INNATA ACTIVADA POR SECUENCIAS OLIGONUCLEOTIDICAS NO METILADAS E INFECCION POR HERPES/VIRUS HUMANO 6 EN PACIENTES CON ESCLEROSIS MÚLTIPLE PAPEL DE LAS VARIANTES COMUNES DE GENES DE PÉPTIDOS GASTROINTESTINALES EN LA RESPUESTA DE LA PERDIDA DE PESO TRAS CIRUGÍA BARIATRICA IDENTIFICACIÓN DE PROTEINAS ASOCIADAS A LA GÉNESIS DEL ANEURISMA DE AORTA ABDOMINAL: PAPEL DE LAS PLAQUETAS Y LAS CÉLULAS MONONUCLEADAS RESONANCIA MAGNÉTICA EN LA ESTADIFICACIÓN DEL CARCINOMA DE PULMÓN: UTILIDAD DE LAS SECUENCIAS POTENCIADAS EN DIFUSIÓN ESTUDIO DEL ESTIGMA Y LA DISCRIMINACIÓN ASOCIADAS A LA DEPRESIÓN EN ESPAÑA Y SU REPERCUSIÓN EN LAS INCAPACIDADES LABORALES TRANSITORIAS POR DEPRESIÓN. (ANTI SITIGMA PROGRAMME EUROPEAN NETWORK-ASPEN) DISEÑO Y EVALUACIÓN DE UN MODELO EXPERIMENTAL PARA ESCLEROSIS LATERAL AMIOTRÓFICA ESPORÁDICA MEDIANTE EL EFECTO CITOTOXICO DEL LCR ESTUDIO INMUNOHISTOQUÍMICO MEDIANTE TISSUE-ARRAY Y CARACTERIZACIÓN MOLECULAR DE MUTACIONES DE C-KIT Y PDGFA DE LOS TUMORES DEL ESTROMA GASTROINTESTINAL (GIST). ESTABLECIMIENTO DE PARÁMETROS PRONÓSTICOS. ALTERACIONES MOLECULARES DE LOS TUMORES ESÓFAGO-GÁSTRICOS: IMPLICACIONES PRONÓSTICAS Y TERAPÉUTICAS. ESTUDIO DE LA REGENRACIÓN EN LA DISCOPATÍA INTERVERTEBRAL DEGENERATIVA CON LA PROTEINA-1 OSTEOGÉNICA RECOMBINANTE HUMANA Y CON CÉLULAS MADRE MESENQUIMALES EN UN MODELO EXPERIMENTAL EN COLA DE RATA. RECUPERACIÓN FUNCIONAL EN LA LUMBALGIA INCAPACITANTE: EFICACIA DE UNA INTERVENCIÓN COGNITIVO-CONDUCTUAL TEMPRANA COHORTE DE GESIDA DE PACIENTES COINFECTADOS POR VIH Y VIRUS DE HEPATITIS C QUE RECIBEN TRATAMIENTO PARA LA HEPATITIS C (2008-2010) FINANCIADOR FMM IP ARROYO GONZÁLEZ, RAFAEL VÍCTOR SERVICIO NEUROLOGÍA FMM TORRES GARCÍA, ANTONIO JOSÉ ENDOCRINOLOGÍA FMM MOÑUX DUCAJÚ, GUILLERMO FMM FERREIROS DOMÍNGUEZ, JOAQUÍN ANGIOLOGÍA Y CIRUGÍA VASCULAR RADIODIAGNÓSTICO FMM LÓPEZ-IBOR ALIÑO, JUAN JOSÉ PSIQUIATRIA FMM MATÍAS GUIU GUIA, JORGE NEUROLOGÍA FMM SANZ ESPONERA, JULIÁN ANATOMÍA PATOLÓGICA FMM SÁNCHEZ PERNAUTE, ANDRÉS ONCOLOGÍA MÉDICA F. MAPFRE LÓPEZ-DURÁN STERN, LUIS TRAUMATOLOGÍA Y C. ORTOPÉDICA F. MAPFRE LEÓN MATEOS, LETICIA REUMATOLOGÍA FIPSE TÉLLEZ MOLINA, MARÍA JESÚS MEDICINA INTERNA III 61