Don Listwin Canary Foundation don@canaryfoundation

Don Listwin
Canary Foundation
don@canaryfoundation.org
Sheet that just needs to get done in
life sciences
to make a difference.
Don Listwin
Canary Foundation
don@canaryfoundation.org
Cycle time is the villain.
Where are the systems models?
Simulation is mandatory.
High throughput is good but factories required.
Industry structure doesn’t understand software.
Software matters. Open source has ½ life of grad student.
Where is cross-omics? Where are analysis tools?
Yikes……
Funding to publishing takes 3 years and taking longer.
Publishing model is archaic. Open access.
We are broke. They are not.
Quit hiding the data. Virtual experiments.
Publish Data Sets
EDRN
Bioinformatics
Tools
Personalized medicine is a crock.
Health care model needs inversion.
Inverting cancer.
Tumor Size
What about a model to treat disease while it can be cured?
D
Fatal
Metastatic
Burden (B)
V(t)=V0exp(rt)
Detection of
primary tumor
M(t) =
k(V(t) – C)
c2B
c1B
C
Observable
metastases
Detection
Death from
of metastases Lung Cancer
Age
Probability of cure by tumor size (cm)
Prob (Cure)
AD
SQ
LC
SC
Tumor Size (cm)
2 stage tests.
Engage the engineers.
Molecular imaging the missing link.
Support this model.
Make more of these.
Sheet that just needs to get done in
life sciences
to make a difference.
Don Listwin
Canary Foundation
don@canaryfoundation.org