Uterine Fibroids

Transcription

Uterine Fibroids
Uterine Fibroids:
Not As Simple As You Think
jeffrey.weinreb@yale.edu
Uterine Leiomyoma
• Most common uterine neoplasm
– 20-30% women >35yo
• Under hormonal influence
– Enlarge during pregnancy or BCP use
– Regress after menopause
• Symptoms
–
–
–
–
Dysmenorrhea
Menorrhagia
Infertility
Pressure sensation
MRI of Uterine Leiomyoma
•
•
•
•
Low signal on T2WIs
Round
Mass effect
Well defined margins
often with
pseudocapsule
• Lacy or confluent
hyperintensity
Uterine Leiomyoma
• As they grow, they may outgrow their blood
supply, resulting in various types of
degeneration
– Hyaline (homogeneous eosinophilic proteinaceous material)
– Myxoid (hyaluronic acid-rich mucopolysaccharide gelatenous
material)
– Cystic
– Calcific
– Hemorrhagic (red or carneous, occurs in pregnancy or with
BCPs)
smooth
muscle
46 yo f pre-UAE
Leiomyoma with edema
T2WI
T2WI
sub
sub
T2WI
edema
Uterine Leiomyoma
• Edema is common
– Scattered or diffuse
– Frequently prominent at periphery
– With extensive edema, get marked
enhancement due to retention of contrast
material within the abundant interstitial spaces
Okizuka H, et al. J Comput Assist Tomogr 1993;17:760-766
Suspect Leiomyosarcoma
• Lyphadenopathy, ascites, or peritoneal
seeding
• Rapid growth of leiomoyoma
Obstet Gynecol 1994;83:414-418
• Hemorrhage
• High signal on T2WIs in >50% of mass
Tanaka YO, et al. J Magn Reson Imaging 2004;20:998-1007
• High signal on T2WIs and intense
enhancement
• Irregular or indistinct margin
Yamashita Y, et al. Radiology 1993;189:721-725
Pattani SJ, et al. Magn Reson Imaging 1995;13:331-333
Schwartz LB, et al. Fertil Steril 1998;70:580-587
Suspect Leiomyosarcoma
• Lypmhadenopathy, ascites, or peritoneal seeding are unusual
• Rapid growth of leiomoyoma is not useful
– <3% of sarcomas have rapidly growing uterus
– <1% of rapidly growing leiomyomas have leiomyosarcomas
• Hemorrhage is not useful
– Hemorrhage is not uncommon in fibroids but unusual in
leiomyosarcomas
• High signal on T2WIs in >50% of mass is not useful
– Not uncommon in fibroids
• High signal on T2WIs and intense enhancement is not useful
– Seen with cellular leiomyomas (composed of compact smooth muscle
cells with little or no collagen)
• Irregular, nodular, or indistinct margins
Leiomyosarcoma
Leiomyoma
Uterine Leiomyosarcoma
• Sarcomatous transformation of preexisting
leiomyoma is rare
– Diagnosis usually made as an incidental
pathologic diagnosis in 0.5% or resected
fibroids
• Most arise independently from myometrial
smooth muscle cells
59 yo f with lung nodule ca and pelvic mass with increased
uptake on PET/CT.
Surgery: Fibroid
ovary
fibroids
51 yo f with pelvic mass
1998
1999
2000
Surgery : granulosa cell tumor ovary with
fibroma and thecal elements (sex cord-stromal tumor)
2003
2004
Exophytic fibroid or fibroma?
Fibroid
Normal ovary
Bridging Vascular Sign
Bridging Vascular Sign
• Vessels that extend from the uterus to supply a pelvic
mass indicate the uterine origin of a juxtauterine mass
• Caused by feeding vessels that arise from the uterine
arteries
• In one study, it was present in in 20/26 exophytic
leiomyomas and absent in all other adnexal masses,
resulting in a diagnostic accuracy of 80%
Kim JC, et al. J Comput Assist Tomogr 2000;24:57060
• But, ovarian malignancies that invade the uterus may
also show this sign
Kim SH, et al. J Comput Assist Tomogr 2001;25:36-42
47 yo f with pelvic pain & solid adnexal mass on US
Uterine Fibroid
U
U
U
Ovarian Vascular Pedicle Sign
• If you can trace gonadal veins anterior to psoas
muscle and common iliac vessels into a pelvic
mass, it indicates that the ovary is the organ of
origin
– Identified in 92% of ovarian masses
• Also seen in 13% of subserosal uterine myomas
– The ovarian veins form a plexus in the broad ligament
that communicates with the uterine plexus
Lee JH, et al. AJR 2003;181:131-137
44 yo f for UAE evaluation
Adenomyotic Cyst
T2WI
T2WI
T2WI
R ovary
Post-C
L ovary
Post-C
Adenomyotic Cyst
• Also known as cystic adenomyosis
• Appears as a an endometrioma-like
intramyometrial hemorrhagic cyst
surrounded by adenomyotic (low signal)
wall
– May be subserosal
Tekeuchi M, et al. RadioGraphics 2011;31:99-115