K9 Advantix II Master TOTAL FILE SIZE

Transcription

CLINIC
GUIDE
Learn how K9 Advantix® II
can help your clinic
Do not use on cats.
STUDIES & COMPARISONS
CLINIC SUPPORT
BROAD SPECTRUM
SPEED OF KILL
REPELLENCY
K9 Advantix® II offers your patients broad-spectrum
protection against fleas, ticks and mosquitoes too.
What do you expect from an external parasite control product for dogs?
In your practice, you’re always looking for quality external parasite control options for your
clients and their dogs. The ideal product should offer:
• Ease of application
• Convenience
• Quality manufacturing from a company you trust
• Reliable efficacy
• Broad-spectrum protection
• Repellency
Why recommend K9 Advantix® II?
• REPEL-and-kill protection – Convenient and effective control of fleas, ticks and
mosquitoes – if fleas, ticks and mosquitoes are repelled or killed, they cannot bite
or attach and transmit the organisms that may cause disease
• Broad-spectrum activity – Achieved through an exclusive combination of three
active ingredients: imidacloprid, permethrin and pyriproxyfen
What is the speed-of-kill of K9 Advantix® II?
• Starts killing reinfesting ticks within 10 minutes*
• Kills reinfesting fleas within two hours
How can K9 Advantix® II help your clinic?
Bayer supports your clinic by offering point-of-purchase materials as well as valuable
strategies like our Free Tubes Program – exclusively for veterinary clinics.
*Three days post-treatment on previously non-treated dogs.1,2
1
Dryden M, Payne P, Smith V, et al. (2006). Evaluation of an imidacloprid (8.8% w/w)-permethrin (44.0% w/w) topical spot-on and a fipronil (9.8% w/w)-methoprene
(8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Ixodes scapularis and Amblyomma americanum ticks on dogs. Vet Ther. 7(3):173-186.
2
Dryden M, Payne P, Smith V, et al. (2006). Evaluation of an imidacloprid (8.8% w/w)-permethrin (44.0% w/w) topical spot-on and a fipronil (9.8% w/w)-methoprene
(8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Rhipicephalus sanguineus and Dermacentor variabilis ticks on dogs. Vet Ther. 7(3):187-198.
Features & benefits
K9 Advantix® II provides your clients with
all these features and benefits in every tube:
•• REPELS and kills fleas, ticks and mosquitoes too
•• For use on dogs and puppies 7 weeks of age and older
•• Lasts for one month
•• Proven efficacy
•• Convenient, once-a-month topical application
•• Easy to apply
STARTS KILLING
TICKS
10
WITHIN
•• Waterproof
TICKS
•• Repels and kills ticks, including the four major species: deer ticks,
MINUTES*
American dog ticks, brown dog ticks and Lone Star ticks
•• Kills ticks that may attach and transmit the organisms that may cause
*Three days post-treatment on
previously non-treated dogs.1,2
disease such as ehrlichiosis, Lyme disease, anaplasmosis and
Rocky Mountain spotted fever
•• Starts killing ticks within 10 minutes*
FLEAS
•• Kills ALL life stages of fleas
•• Prevents fleas on a treated dog from infesting the home
•• Kills fleas within 12 hours, and kills reinfesting fleas within 2 hours
MOSQUITOES, BITING FLIES AND LICE
•• REPELS and kills mosquitoes, often before they have a chance to take a
blood meal
•• REPELS biting flies
CONVENIENT,
•• Kills lice
ONCE-A-MONTH
TOPICAL APPLICATION
K9 Advantix® II is waterproof.†
*Three days post-treatment on previously non-treated dogs.1,2
We recommend use of soap-free shampoo.
†
2
Waterproof protection for dogs
With K9 Advantix® II, there is no need to reapply after a monthly bath or
weekly swimming. A study has shown that the combination of imidacloprid
and permethrin will continue to be effective after exposure to water – whether
your dog has gone for a swim, has been given a bath or has been in the rain.3
WATERPROOF
This waterproof protection can be used on puppies as young as seven
weeks of age. Consider recommending a soap-free shampoo and towel
dry before monthly application.
Imidacloprid is distributed in the skin’s water-resistant lipid layer,
the hair follicles and the sebaceous glands.4
Water-resistant
lipid layer
Epidermis
Dermis
Sebaceous gland
Hair follicle
•
Imidacloprid
Subcutaneous
layer
1
Dryden M, Payne P, Smith V, et al. (2006). Evaluation of an imidacloprid (8.8% w/w)-permethrin (44.0% w/w) topical spot-on and a fipronil
(9.8% w/w)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Ixodes scapularis and Amblyomma
americanum ticks on dogs. Vet Ther. 7(3):173-186.
2
Dryden M, Payne P, Smith V, et al. (2006). Evaluation of an imidacloprid (8.8% w/w)-permethrin (44.0% w/w) topical spot-on and a fipronil
(9.8% w/w)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Rhipicephalus sanguineus and Dermacentor
variabilis ticks on dogs. Vet Ther. 7(3):187-198.
3
Data on file. Bayer HealthCare Animal Health.
4
Chopade H, Eigenberg D, Solon E, et al. (2010). Skin distribution of imidacloprid by microautoradiography after topical administration
to beagle dogs. Vet Ther. Winter;11(4):E1-E10.
2
3
The power of repellency
What makes repellency so important?
If a flea, tick or mosquito is repelled or killed, it cannot bite or attach and transmit the organisms
that may cause disease. Your clients need to know that not all products repel and kill.
Fleas
Vector-borne diseases are mostly transmitted once a parasite bites or attaches to the host.
Even if the parasite dies later on, transmission may have already occurred, and the disease may
still be spread to the host dog. That’s why repelling or killing parasites is so crucial in a
pet owner’s approach to caring for their dog’s overall health.
What does K9 Advantix® II repel?
Ticks
K9 Advantix® II REPELS and kills fleas, ticks and mosquitoes too.
Why recommend K9 Advantix® II?
K9 Advantix® II offers broad-spectrum protection against fleas, ticks and mosquitoes by
incorporating imidacloprid, permethrin and pyriproxyfen to create a repel-and-kill mode
of action. K9 Advantix® II offers a preventive approach to pest protection.
K9 Advantix® II vs the Competition
TICKS ARE THE
NexGard® (afoxolaner)
Chewables
Frontline® Plus
Bravecto®
(fluralaner)
Topical
Systemic
Topical
Systemic
Fleas
Repels AND kills
Kills
Kills
Kills
Ticks
Repels AND kills
Kills
Kills
Kills
Mosquitoes
Repels AND kills
No label claim
No label claim
No label claim
Based on product labels
K9 Advantix® II REPELS and kills fleas, ticks and mosquitoes too.
If fleas, ticks and mosquitoes are repelled or killed, they cannot bite
or attach and transmit the organisms that may cause disease.
Rosenthal M. (2008). Vector-borne disease important area of research; ticks most common vector. Vet Forum. 25(12):8-9.
Anderson FJ, Magnarelli LA. (2008). Biology of ticks. Infect Dis Clin North Am. 22(2):195-215.
Ribeiro JM, Makoul GT, Levine J, et al. (1985). Antihemostatic, anti-inflammatory, and immunosuppressive properties of the saliva of a tick,
Ixodes dammini. J Exp Med. 161(2):332-344.
1
2
3
4
Mosquitoes
1
#
CARRIER OF
CANINE
VECTOR-BORNE DISEASE.1
The longer an infected
tick remains attached to a
dog, the greater the risk of
transmitting a disease agent.
How diseases can
be transmitted
1
The questing tick finds a dog, selects a feeding site and
prepares to penetrate the skin with its mouthparts.
5-12
DAYS
2 is how long an
adult tick can feed
on a dog, if left undisturbed. The saliva
of most ticks has substances that can
prevent their hosts from recognizing
they have attached.3
2
Tick saliva facilitates feeding by acting as a local anesthetic, an
anticoagulant and a medium for the transfer of disease agents.
3
The tick, if uninterrupted, may feed for several days on
the dog’s blood, sharing whatever bacteria and parasites
it may be carrying.
4
The fully fed (replete) female tick will now detach and drop into the environment,
ready to lay thousands of eggs and potentially leaving behind, in the dog, agents
that may result in diseases such as Lyme disease, ehrlichiosis, anaplasmosis and
Rocky Mountain spotted fever. The female tick may also pass parasites or
infectious agents to her offspring through transovarial transmission.
Learn more
5
(continued)
Common tick-transmitted diseases:
• Lyme disease
• Rocky Mountain spotted fever
• Anaplasmosis
• Ehrlichiosis
Ticks are the #1 carrier of Canine Vector-Borne Diseases
(CVBDs) in the US1
Learn more
When an infected parasite (such as a tick, flea or mosquito) attaches or bites and feeds on
the blood of a dog, it can pass the pathogen from itself to the new host. Ticks are competent
vectors because they feed on several hosts, molt through different life stages, require large
blood meals, and feed for long periods of time.1
General transmission times of common canine tick-borne diseases
Pathogen
Feeding time
to infect*
Recognized and/or potential tick vectors
Anaplasmosis
Anaplasma spp.
4 to 48 hours2
Rhipicephalus sanguineus (brown dog tick)
Ixodes scapularis (deer tick)
Ixodes pacificus (western black-legged tick)
Rocky Mountain
spotted fever
Rickettsia rickettsii
4 to 48 hours2
Dermacentor variabilis (American dog tick)
Dermacentor andersoni (Rocky Mountain wood tick)
Amblyomma americanum (Lone Star tick)
Ehrlichiosis
Ehrlichia spp.
≥ 3 hours3
Dermacentor variabilis (American dog tick)
Amblyomma americanum (Lone Star tick)
Lyme disease
Borrelia burgdorferi
24 to >48 hours4
Ixodes scapularis (deer tick)
Ixodes pacificus (western black-legged tick)
0
1
5
PL
AT I N U M S p
on
s
o
r
2
*Some studies performed in non-canine hosts. Transmission time may also vary with the physiologic state of individual ticks.
Talk to your Bayer
For more information about canine
vector-borne diseases, visit capcvet.org.
Rosenthal M. (2008). Vector-borne disease important area of research; ticks most
common vector. Vet Forum. 25(12):8-9.
1
6
2
Nicholson WL, Allen KE, McQuiston JH, et al. (2010). The increasing recognition of
rickettsial pathogens in dogs and people. Trends Parasitol. 26(4):205-212.
3
Fourie JJ, Stanneck D, Luus HG, et al. (2013). Transmission of Ehrlichia canis by
Rhipicephalus sanguineus ticks feeding on dogs and on artificial membranes.
Vet Parasitol. 197(2013):595-603.
4
Little SE. From attachment to disease: Diversity in pathogen transmission by ticks.
http://www.bayeranimalhealthsymposium.com/little-attachment.shtml.
rep today about
recommending
the power of
repellency for
your patients.
7
(continued)
K9 Advantix® II and pathogen transmission interruption:
The following studies support imidacloprid + permethrin, two of the active ingredients
in K9 Advantix® II.
By effectively repelling and killing I. scapularis (deer tick), K9 Advantix® II may help
reduce the risk of Borrelia burgdorferi (Lyme disease) transmission*1,2
•• Two separate studies differing only by tick challenge study days (day 7 vs. day 25)
•• Each study contained one group of 8 dogs treated on day 0 with imidacloprid and
permethrin, and one control group of 8 dogs
•• All dogs were infested with 80–100 I. scapularis (deer tick) on study day 7 or study day 25.
Ticks remained in place for 7 days in the first study and 5 days in the second study
•• 10 mL of whole blood drawn on study days 14, 25, 42, 56, 70, and 91 in the day 7
challenge protocol, and study days 42, 56, 70, 90, and 110 in the day 25 challenge protocol
Group A
Number of dogs testing positive
by kELISA for B. burgdorferi in the
day 7 challenge study
% positive dogs
by kELISA for B. burgdorferi in the
day 25 challenge study
% positive dogs
Lyme disease may be
transmitted as fast as
24
hours
after attachment.
‡4
‡Studies performed in non-canine hosts.
Transmission time may also vary with the
physiologic state of individual ticks.
Group B
(treated once with imidacloprid
and permethrin)
(not treated)
0 out of 8
8 out of 8
0%
100%
0 out of 8
7 out of 8
0%
88%
According to the
Companion Animal Parasite Council,
of the dogs tested for Lyme disease,
1 in 16 dogs in the US tested positive
for Lyme disease.** 3
** Only tests reported by
two national laboratories.
In the above studies, by repelling and killing ticks, K9 Advantix® II* effectively
prevented the transmission of the organisms that can cause Lyme disease.
*Studies were performed with imidacloprid and permethrin (two of the active ingredients in K9 Advantix® II).
2013 CAPC STATS†:
134,749 dogs tested positive for Lyme disease across 50 states†3
63,854 dogs tested positive for Ehrlichiosis across 50 states†3
68,286 dogs tested positive for Anaplasmosis across 50 states†3
The numbers for each disease represent the total number of positive dogs out of all dogs tested at only two national laboratories.
Therefore, the true prevalence may be higher.
†
1
Spencer JA, Butler JM, Stafford KC, et al. (2003). Evaluation of permethrin and imidacloprid for prevention of Borrelia burgdorferi transmission
from blacklegged ticks (Ixodes scapularis) to Borrelia burgdorferi-free dogs. Parasitol Res. 90(Suppl 3):S106-S107.
2
Blagburn BL, Spencer JA, Butler JM, et al. (2005). Prevention of transmission of Borrelia burgdorferi and Anaplasma phagocytophilum from
ticks to dogs using K9 Advantix and Frontline Plus applied 25 days before exposure to infected ticks. Intern J Appl Res Vet Med. 3(2):69-75.
Parasite Prevalence Maps. CAPC website. Available at: http://www.capcvet.org/parasite-prevalence-maps/. Accessed 10/24/14.
3
Little SE. From attachment to disease: Diversity in pathogen transmission by ticks. http://www.bayeranimalhealthsymposium.com/
little-attachment.shtml.
4
8
5
Fourie JJ, Stanneck D, Luus HG, et al. (2013). Transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks feeding on dogs and on artificial
membranes. Vet Parasitol. 197(2013):595-603.
6
Otranto D, Paradies P, Testini G, et al. (2008). Application of 10% imidacloprid/50% permethrin to prevent Ehrlichia canis exposure in dogs
under natural conditions. Vet Parasitol. 153(3-4):320-328.
7
Blagburn BL, Spencer JA, Billeter SA, et al. (2004). Use of imidacloprid-permethrin to prevent transmission of Anaplasma phagocytophilum
from naturally infected Ixodes scapularis ticks to dogs. Vet Ther. 5(3):212-217.
A recent publication
showed that ticks
may be able to
transmit certain
disease agents to
dogs in as little as
3 hours.
5
By effectively repelling and killing R. sanguineus (brown dog tick), K9 Advantix® II may help
reduce the risk of Ehrlichia canis (ehrlichiosis) transmission under field conditions*6
•• 535 dogs enrolled in a year-long trial. Study was conducted in field conditions following
Good Clinical Practice (GCP) guidelines. Dogs were treated from April to November
•• Dogs were housed in an environment with R. sanguineus (brown dog tick)
•• The protection efficacy was determined by serologic testing Indirect Fluorescent
Antibody Test (IFAT)
Reduced rate of transmission of E. canis observed in the study*6
% of protection
According to the
Companion Animal
Parasite Council,
of the dogs tested
for ehrlichiosis,
1 in 33 dogs in
the US tested
positive, and of
the dogs tested
for anaplasmosis,
1 in 31 dogs in the
US tested positive.‡3
‡
Only tests reported by
two national laboratories.
Number E. canis seropositive
dogs at final follow-up
% E. canis seropositive dogs at
final follow-up
Group A
Group B
(treated once a month with
imidacloprid and permethrin)
(treated twice a month with
100%
95.57%
Group A
Group B
Group C
(treated once a month with
(treated twice a month with
(not treated)
0
1
25
0.00%
0.6%
15.3%
In the above study, by repelling and killing ticks, K9 Advantix® II* effectively
reduced the transmission of organisms that can cause ehrlichiosis.
*Study performed with imidacloprid and permethrin (two of the active ingredients in K9 Advantix® II).
By effectively repelling and killing I. scapularis (deer tick), K9 Advantix® II may help reduce the
risk of Anaplasma phagocytophilum transmission†2,7
•• Each study contained one group of 8 dogs treated on day 0 with imidacloprid and
permethrin, and one control group of 8 dogs
•• All dogs were infested with 80–100 I. scapularis (deer tick) on study day 7 or study day 25
•• 10 mL of whole blood drawn on study day 90 in the day 7 challenge protocol, and study day 110
in the day 25 challenge protocol for serologic testing
•• Ticks were removed after 7 days in the 7-day study and 5 days in the 25-day study
Reduced rates of transmission of A. phagocytophilum observed in the studies†2,7
Group A
Group B
(treated once with imidacloprid
and permethrin)
(not treated)
by IFAT for A. phagocytophilum in
the day 7 challenge study
0 out of 8
7 out of 8
% positive dogs on study day 90
0%
88%
by IFAT for A. phagocytophilum in
the day 25 challenge study
0 out of 8
7 out of 8
% positive dogs on study day 110
0%
88%
In the above studies, by repelling and killing ticks, K9 Advantix® II† effectively
prevented the transmission of the organisms that can cause anaplasmosis.
Studies were performed with imidacloprid and permethrin (two of the active ingredients in K9 Advantix® II).
†
9
Speed of kill
Your clients have a need for speed
It doesn’t take long for an infected parasite to transmit the pathogens behind such diseases
as Lyme disease, Rocky Mountain spotted fever and more.
•• K9 Advantix® II kills fleas and ticks quickly*1-5
•• Imidacloprid stops biting fleas within 3–5 minutes.*3-5
•• Fleas bites can cause health problems such as:
•• Flea allergy dermatitis
•• Anemia (with severe flea infestations)
•• Fleas are killed within 12 hours of initial application
•• Reinfesting fleas are killed within 2 hours
STARTS KILLING
For speed of kill on ticks, day 3 study data demonstrated quick and effective results:
•• 96.4% to 100% of repelled ticks were dead within 10 minutes
•• In this study, 100% tick control was achieved 24 hours after the first infestation
TICKS
10
WITHIN
*Three in vivo experiments were conducted to evaluate the effect of Advantage® Topical Solution (imidacloprid) on fleas
(Ctenocephalies felis). A total of seven (7) dogs were treated with Advantage® Topical Solution. Seven (7) days after application,
areas on the dogs were shaved to allow visual observation. A petri dish was attached over each spot, and then infested with
up to 100 fleas. In all replicates, the fleas stopped their feeding activity and started tetanic trembling movements within
3–5 minutes. In one hour, all fleas were dead.
MINUTES‡
T hree days post-treatment on
previously non-treated dogs.1,2
‡
Day 3 post-treatment study data demonstrated quick and effective results
% Repelled
Amblyomma americanum
Lone Star tick1
Ixodes scapularis
deer tick1
Rhipicephalus sanguineus
brown dog tick2
Dermacentor variabilis
American dog tick2
% Repelled ticks that died
% Tick control
10 min
10 min†
3 hr
3 hr
24 hr
86%
100%
100%
88.6%
100%
72%
96.4%
100%
92.9%
100%
83%
100%
100%
100%
100%
93%
99%
100%
100%
100%
Immediately after the completion of the 10-minute exposure period, the ticks were found dead or moribund.
†
•• Imidacloprid and permethrin were applied to dogs on study day 0
•• 25 adults of each tick species were applied to dogs on study day 3
Your clients will appreciate a product
that quickly kills fleas and ticks.
Dryden M, Payne P, Smith V, et al. (2006). Evaluation of an imidacloprid (8.8% w/w)-permethrin (44.0% w/w) topical spot-on and a
fipronil (9.8% w/w)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Ixodes scapularis and
Amblyomma americanum ticks on dogs. Vet Ther. 7(3):173-186.
1
Dryden M, Payne P, Smith V, et al. (2006). Evaluation of an imidacloprid (8.8% w/w)-permethrin (44.0% w/w) topical spot-on and a
fipronil (9.8% w/w)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Rhipicephalus sanguineus
and Dermacentor variabilis ticks on dogs. Vet Ther. 7(3):187-198.
2
Mehlhorn H, Hansen O, Mencke N. (2001). Comparative study on the effects of three insecticides (fipronil, imidacloprid, selamectin)
on developmental stages of the cat flea (Ctenocephalides felis Bouché 1835); a light and electron microscopic analysis of in vivo and
in vitro experiments. Parasitol Res. 87(3):198-207.
3
Mehlhorn H. (2000). Mode of action of imidacloprid and comparison with other insecticides (i.e., fipronil and selamectin) during
in vivo and in vitro experiments. Suppl Compend Contin Educ Pract Vet. 22(4A):4-8.
4
Mehlhorn H, Mencke N, Hansen O. (1999). Effects of imidacloprid on adult and larval stages of the flea Ctenocephalides felis after
in vivo and in vitro application: a light- and electron-microscopy study. Parasitol Res. 85(8-9):625-637.
5
10
The longer
an infected
tick remains
attached to a
dog, the greater
the risk of
transmitting a
disease agent.
11
The value of a broad spectrum
What external parasites should your preventive product target?
Dog owners want to make sure they’re doing everything they can to help their dog
have protection against parasites, which is no small task considering the many parasites
that a dog can encounter throughout the day. K9 Advantix® II REPELS and kills fleas,
ticks and mosquitos too, kills ALL life stages of fleas, repels biting flies and kills lice.
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K9 Advantix® II
offers your clients
broad-spectrum
protection against
LICE
fleas, ticks and
mosquitoes too.
How does K9 Advantix® II provide broad-spectrum protection?
The combination of imidacloprid and permethrin increases neuronal activity in vitro.1
•• Imidacloprid and permethrin attack different receptors on the parasite’s nerve,
causing an initial excitatory effect and hyperactivity, and then death
•• Pyriproxyfen, an insect growth regulator (IGR), affects the early flea life stages
to prevent development to the next stage
Neural activity of imidacloprid and permethrin
Nervous System Activity1
Baseline
2 cps
300 nM Imidacloprid
42 cps
1500 nM Permethrin
25 cps
1500 nM Permethrin
300 nM Imidacloprid
65 cps
Each compound acts on a different receptor area of the nerve cell.
•• Imidacloprid: (nicotinic receptors) irreversibly opens nicotinic receptors on
postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic
paralysis and death
•• Permethrin: (sodium channels) causes prolonged sodium ion exchange across
neuronal membranes, resulting in constant nerve discharge followed by spastic
paralysis and death
12
Activity on Fleas
K9 Advantix® II effectively breaks the flea life cycle
5%
Adult fleas hatch from
the cocoon and continue
to infest the pet.
of a flea
ADULT FLEAS
infestation
is visible as adults.
The other 95%
of an infestation
live as immature
stages inside the
pet’s surroundings.2
In just 30 days,
10
FLEAS
can become an
infestation of up to
250,000
1
Adult fleas lay eggs after
a blood meal, which
then drop off into
the environment.
4
5% of an infestation2
2
FLEA CYCLE
FLEA PUPAE
FLEA EGGS
Flea larvae spin
a cocoon and develop
into pupae
(approximately 1–2 weeks).3
3
FLEA LARVAE
Flea larvae hatch
out of flea eggs
when conditions are
right (warm and humid).
With an IGR as part of your flea control program, the flea life cycle is disrupted at multiple
stages, which helps your clients treat and prevent flea infestations.
on your dog
and in your home.4
Fleas and flea bites
Fleas can aggravate a dog and affect the way he or she bonds with his or her owner. More
importantly, fleas may transmit tapeworms or cause skin problems, such as flea allergy dermatitis.
Integral parts of
integrated flea
control include
an adulticide
to provide the
necessary adult
flea kill on the
dog and an insect
growth regulator
to suppress the
reproduction of
surviving adults.
M.W. Dryden, DVM, PhD
Imidacloprid, an active ingredient in K9 Advantix® II, is effective against adult fleas and larval
flea stages. In addition to its adulticide flea efficacy, imidacloprid demonstrates a larvicidal flea
efficacy when the larvae in the dog’s surroundings come into contact with the K9 Advantix® IItreated dog. Another benefit of imidacloprid is that fleas do not need to bite the treated animal
to be exposed to the active ingredient.
K9 Advantix® II contains pyriproxyfen, an IGR that contains ovicidal and larvicidal properties to
target flea infestations.
1
Methfessel C, Turberg A. (2003). An in vitro demonstration of synergy between imidacloprid and permethrin. Suppl Compend Contin Educ
Pract Vet. 25(5A):11-14.
Grace SF. Fleas. In: Norsworthy GD, Crystal MA, Grace SF, et al., eds. (2006). The Feline Patient. 3rd ed. Ames, IA: Blackwell Publishing; 106-107.
2
3
Dryden MW, Payne P, Zurek L. (2003). Pests That Affect Human Health: Fleas Infesting Pets and Homes. Manhattan, KS: Kansas State University
Agricultural Experiment Station and Cooperative Extension Service. MF-760.
4
Protecting animals in summer. WAF website.
Available at: http://www.worldanimalfoundation.net/f/SafeguardingAnimalsfromSummerHeatandPests.pdf. Accessed July 20, 2012.
13
(continued)
Activity on Ticks
K9 Advantix® II effectively repels and kills the most common tick species.
View more supporting studies in the ‘Repellency’ section.
K9 Advantix® II repels and kills:
Deer ticks
(Ixodes scapularis)
Potential vector of:
•• Anaplasmosis
•• Lyme disease
Male
Male
Learn more
Female
American dog ticks
(Dermacentor variabilis)
Male
•• Rocky Mountain
spotted fever
•• Ehrlichiosis
can survive and
reproduce at
Female
temperatures
Brown dog ticks
(Rhipicephalus sanguineus)
•• Anaplasmosis
Male
Some ticks
spotted fever
•• Ehrlichiosis
as low as1
40°F
Female
Lone Star ticks
(Amblyomma americanum)
Male
spotted fever
•• Ehrlichiosis
Female
Pictures supplied by Kansas State University CVM ITC. M.W. Dryden, DVM, PhD, and P.A. Payne, DVM, PhD, 2010.
14
8
Real-World Field Study
The combination of imidacloprid and permethrin is effective
against A. americanum (Lone Star tick)2
•• The effects of imidacloprid and permethrin on ticks can result in prevention of
attachment, inhibition of feeding and rapid death
•• In a natural tick exposure study, the combination of imidacloprid and permethrin
demonstrated an efficacy at 48 hours post-exposure (ticks repelled and/or killed) of 93.5%
or above from study day 3 through the duration of the study (or day 28) when treated on day 0
•• Imidacloprid and permethrin were still effective at 28 days
Tick repellency 2 to 3 hours after exposure 2
100.0%
90.0%
88.0%
77.5%
80.0%
68.1%
(%) Efficacy
70.0%
64.3%
68.5%
60.0%
50.0%
40.0%
30.0%
20.0%
10.0%
00.0%
3
7
14
21
28
Study day
Amblyomma americanum ticks repelled and/or
killed 48 hours after exposure 2
100.0%
93.5%
98.9%
94.6%
94.1%
96.6%
90.0%
80.0%
(%) Efficacy
70.0%
60.0%
50.0%
40.0%
30.0%
Offer broad-spectrum
protection against
fleas, ticks, mosquitoes,
biting flies and lice.
20.0%
10.0%
00.0%
3
7
14
21
28
Study day
Studies were performed with imidacloprid and permethrin (two of the active ingredients in K9 Advantix® II).
Values at all time points were significant (P < .05) compared to controls.
Ogden NH, Lindsay LR, Beauchamp G, et al. (2004). Investigation of relationships between temperature and developmental rates of ticks
Ixodes scapularis (Acari: Ixodidae) in the laboratory and field. J Med Entomol. 41(4):622-633.
1
Dryden MW, Payne PA, Smith V, et al. (2006). Efficacy of imidacloprid (8.8% w/w) plus permethrin (44% w/w) spot-on topical solution against
Amblyomma americanum infesting dogs using a natural tick exposure model. Vet Ther. 7(2):99-106.
2
15
(continued)
Activity on Mosquitoes
K9 Advantix® II repels and kills mosquitoes for up to four weeks.
In addition to year-round protection with a heartworm preventive, the American Heartworm
Society recommends the following steps to help reduce pet exposure to mosquitoes1:
•• Use approved mosquito repellants/environmental yard controls
•• Keep pets in at night
•• Contact an appropriate agency for mosquito control
K9 Advantix® II is not labeled for the prevention of heartworm disease
and should not eliminate the need for a heartworm preventive product.
Learn more
Mosquitoes can transmit heartworms
Once an infected mosquito bites a dog, heartworm larvae may migrate to the bloodstream
and eventually invade the lungs and heart.
•• Mosquito bites can lead to stress and skin infection from scratching
•• Mosquitoes are the vector of heartworms
•• They can be a year-round concern in many parts of the country
•• A single dog can be infected with as many as 250 heartworms.
•• It only takes one bite from an infected mosquito2
Study Support – Mosquitoes
Kill efficacy against mosquitoes3
•• Three dogs in Group 1 were treated with a combination of imidacloprid and
permethrin on study day 0; three dogs in Group 2 received a placebo
•• On test days, dogs were placed in mosquito-rearing, screened cages with
50 female mosquitoes
•• After 1 hour, dogs were removed from the cage and mosquitoes were counted
and analyzed
This study demonstrated that the combination of imidacloprid and permethrin killed up
to 98.3% of mosquitoes and was up to 95.2% effective in reduction of blood feeding3
Kill efficacy against mosquitoes
16
Days post-treatment
88%
of dog owners
would want their flea
and tick product to
also protect against
mosquitoes.*
*Pet owners were recruited from a
nationally representative sample
of U.S. households. 88% of the 780
participants, who were dog owners
who purchased any flea/tick product
in the past 12 months, responded
that they agreed with the statement
that they would want their flea and
tick product to protect their dog
against mosquito bites.4
Activity on Biting Flies
K9 Advantix® II repels and prevents blood-feeding by biting flies.
Efficacy against biting flies5
This study demonstrated that the combination of imidacloprid and permethrin repels
(up to 96.9%) and prevents biting flies from blood feeding on dogs.5
•• The combination of imidacloprid and permethrin was applied to 8 dogs on study day 0
•• All dogs were exposed to Stomoxys calcitrans (stable fly) for 30 minutes on study days 1,
8, 18, 22, and 29
For more information,
check the studies
section of this guide,
or contact your
Bayer representative
to see how
broad-spectrum
protection can help
your patients.
Photo credit: Courtesy of Lynette Cole, DVM, DACVD
Activity on Chewing Lice
K9 Advantix® II kills chewing lice.
Efficacy against chewing lice6
This study demonstrated that the combination of imidacloprid and permethrin is
up to 100% effective against chewing lice.6
•• 20 dogs with natural Trichodectes canis (chewing-louse) infestations: 10 treated with
imidacloprid and permethrin; 10 in non-treated control group
•• Imidacloprid and permethrin were applied to treatment group on study day 0
•• Louse counts were conducted before treatment (study day -1) and on study days 1, 2,
7, 14, 21, 28, and 35
1
American Heartworm Society. Heartworm Preventive Resistance: Is it Possible? https://www.heartwormsociety.org/newsroom/in-thenews/81-heartworm-preventive-resistance-is-it-possible. Published December 5, 2013. Accessed November 13, 2014.
Bowman DD, Atkins CE. (2009). Heartworm biology, treatment, and control. Vet Clin North Am Small Anim Pract. 39(6):1127-1158.
2
3
4
5
Stanneck D, Ketzis J, Doyle J, et al. (2008). Lice management options: efficacy of three imidacloprid-containing formulations against natural
lice (Trichodectes canis) infestations in dogs. Compend Contin Educ Pract Vet. 30(6B):1-8.
6
10
17
K9 Advantix® II supports your
clinic’s marketing efforts
We share your vision
At Bayer, we rely on your recommendation of our products and we truly appreciate your
advocating our brand. We are committed to supporting veterinarians and their clinics through
our incentive programs, including Bayer Partners and the Free Tubes Program. Our new pet kits
include a complimentary tube of K9 Advantix® II to help initiate the use of a preventive product.
We also offer continuing education and symposiums at relevant trade shows, and sponsor several
charities that support animal causes.
Why carry a trusted brand?
The term “brand” embodies something beyond packaging or trademarks. It’s
a persona that lives in the minds – and sometimes hearts – of the consumer.
When you offer a certain brand at your clinic, your clients’ confidence in that
brand is strengthened and they may be more inclined to make purchases.
Your clients recognize K9 Advantix® II
K9 Advantix® II
has a total brand
awareness of
63%
among dog-only
households†
Clients may be likely
to ask you for this
product by name.
From TV commercials to magazine ads to social media, K9 Advantix® II has
positioned itself as a trusted brand from a well-established company.
•• Loyal customer base – 94% of K9 Advantix® II users show repeat purchase intent*
•• More than 72% of reviewers on K9AdvantixII.com would recommend K9 Advantix® II2
More than
72%
of reviewers
on K9AdvantixII.com
would recommend
K9 Advantix® II.2
TO YOU,
HE’S MORE
THAN JUST
A PET.
So protect your furry friend
with K9 Advantix® II.
Its broad-spectrum
protection kills fleas,
ticks and mosquitoes too.
K9 Advantix® II is for use on dogs only.
©2014 Bayer HealthCare LLC, Animal Health Division, Shawnee Mission, Kansas 66201 Bayer (reg’d), the Bayer Cross (reg’d),
K9 Advantix® and for the love of dog™ are trademarks of Bayer.
K141169
Scan to watch
TV ad
Brand loyalty can become clinic loyalty in one visit.
Make sure your customers see what they’re looking for
and keep them coming back for K9 Advantix® II.
*Pet owners were recruited from a nationally representative sample of U.S. households. Consumers were
required to own a dog, be at least 18 years of age, and be the primary decision maker regarding their pet’s
health or pet products purchased. Current users of K9 Advantix® II responded that they “definitely will” or
“will” purchase K9 Advantix® II again the next time they purchase a flea or tick control product for their dog.1
et owners were recruited from a nationally representative sample of U.S. households. Consumers were
P
health or pet products purchased. Pet owners were asked which flea and tick products they could think of
or had ever heard of.3
†
18
TV ads have been
proven to drive
viewers to ask their
veterinarian about
the product.4
We work to bring clients through your door
As always, we’re doing our part to reach out to dog owners to increase your foot
traffic, and remind pet owners to come back to your clinic.
Some of our ongoing activities include:
85%
Email and direct mail
We reach out to current and potential customers and drive
them to purchase K9 Advantix® II in veterinary clinics.
of pet
owners
Promotional materials
for the
We create branded signage for
you to display at your clinic to
generate interest and steer
purchase decisions.
purchase
flea and/or tick
products at the same
place they have
purchased before.*
Therefore it’s
important for us to
remind them to come
back to your clinic.
of dog
Reminder cards
We offer cards you can
send to clients as a reminder
Frequently that
asked questions
it’s time to come in and
purchase moreGetproduct.
all these benefits in every tube
Broad-spectrum protection against
fleas, ticks and mosquitoes too
Q How is K9 Advantix® II different?
A The formulation contains the active ingredients imidacloprid,
pyriproxyfen and permethrin, which work together to effectively
REPEL and kill fleas, ticks and mosquitoes. No other company offers
a flea control product with imidacloprid.
Q How long does K9 Advantix® II last?
A A single application of K9 Advantix® II keeps working for a month.
Veterinarians recommend applying every month to help keep
dogs protected year-round. Keep in mind that only 5% of a flea
infestation consists of adult fleas that you can see on your
animal. The remaining 95% of the infestation is made up of fleas
in immature stages.2
• REPELS and kills fleas, ticks and
mosquitoes too
• Kills ALL life stages of fleas
• Kills fleas within 12 hours, and kills
Free Tubes Program
Q My dog is strictly indoors.
Should I still use K9 Advantix® II?
reinfesting fleas within 2 hours
• Starts killing ticks within
10 minutes*
*Three days post-treatment on
previously untreated dogs.5
for the
*We recommend
use of a soap-free shampoo.
• For use on dogs and puppies
• REPELS and kills mosquitoes,
7 weeks of age and older
topical application
often before they have a
chance to take a blood meal
treated with K9 Advantix® II because fleas and ticks can be brought
into the home by people or other pets without pet owners even
realizing it. In fact, the saliva of most ticks has substances that can
prevent their hosts from recognizing they have attached.3
Scan to learn more
or visit
WhyK9AdvantixII.com
• Convenient, once-a-month
A Bayer-funded program
(exclusively for veterinary
clinics) that provides
competitive discounts
on K9 Advantix® II.
A Yes. Even dogs that spend the majority of their time indoors should be
of dog
• REPELS biting flies
• Kills lice
• Waterproof*
©2014 Bayer HealthCare LLC, Animal Health Division, Shawnee Mission, Kansas 66201
Bayer, the Bayer Cross and K9 Advantix are registered trademarks of Bayer. PS14157
Q I only see fleas on one of my dogs.
Is it sufficient to just treat the infested dog?
A No. Fleas can jump up to 18.5 inches forward and 6.5 inches high,4
so all dogs in the home should be treated, since the infested dog is
likely to pass on fleas to other dogs he is in contact with.
Q Can I use K9 Advantix® II on my cat?
A No. K9 Advantix® II is specifically formulated for dogs. Cats have a
unique physiology and can’t metabolize certain compounds of
K9 Advantix® II.
For more information, visit
K9AdvantixII.com
For coverage beyond your dog, try Advantage™ yard and premise products.
Consumer reviews. PetParents.com website. Available at: http://www.petparents.com/show.aspx/
products/k9-advantix-ii/consumer-reviews. Accessed January 15, 2013.
1
Grace SF. Fleas. In: Norsworthy GD, Crystal MA, Grace SF, et al., eds. (2006). The Feline Patient. 3rd ed.
Ames, IA: Blackwell Publishing; 106-107.
2
Ribeiro JM, Makoul GT, Levine J, et al. (1985). Antihemostatic, antiinflammatory, and immunosuppressive
properties of the saliva of a tick, Ixodes dammini. J Exp Med. 161(2):332-344.
3
ed
mend
recom BY
ns
ina ria
ve ter
Cadiergues MC, Joubert C, Franc M. (2000). A comparison of jump performances of the dog flea,
Ctenocephalides canis (Curtis, 1829) and the cat flea, Ctenocephalides felis felis (Bouché, 1835).
Vet Parasitol. 92(3):239-241.
4
Data on file. Bayer HealthCare, Animal Health.
5
©2014 Bayer HealthCare LLC, Animal Health Division, Shawnee Mission, Kansas 66201
Bayer (reg’d), the Bayer Cross (reg’d), Advantage™ and K9 Advantix® are trademarks of Bayer.
Visit K9AdvantixII.com for more information.
Ready to receive some
special promotions
and client educational
materials for your clinic?
Frontline is a registered trademark of Merial.
Fiproguard is a registered trademark of Sergeant’s Pet Care Products, Inc.
PS14154
Broad-spectrum protection against
fleas, ticks and mosquitoes too
The Free Tubes Program
is offered exclusively to
veterinary clinics.
Contact your
Bayer rep today.
*2,500 pet owners were recruited from a nationally representative sample of U.S. households. Consumers
were required to own a dog and/or cat and have purchased flea and/or tick products in the last 12 months.
Pet owners answered the question “I will likely continue to purchase flea and/or tick products from the
same source” with “yes.”5
1
2
3
4
5
19
Studies & comparisons
K9 Advantix® II competitive profiles
NexGard® (afoxolaner) Chewables, Bravecto® (fluralaner), Frontline® Plus, Frontline® TriTak®
and Parastar® Plus kill fleas and ticks, but DO NOT REPEL. If a flea or tick is repelled or killed, it
cannot bite or attach and transmit organisms that may cause disease.
K9 Advantix® II vs NexGard® (afoxolaner) Chewables
NexGard® (afoxolaner) Chewables
K9 Advantix® II
Kills
Repels
Kills
Fleas
√
√
√
Ticks
√
√
√
√
√
√*
Mosquitoes
Biting flies
Chewing lice
Repels
K9 Advantix® II
REPELS and kills
fleas, ticks and
mosquitoes too.
√
Based on label comparison to K9 Advantix® II indications
*Dermacentor variabilis, Amblyomma americanum and Ixodes scapularis
K9 Advantix® II vs Bravecto® (fluralaner)
Bravecto® (fluralaner)
K9 Advantix® II
Fleas
Ticks
Mosquitoes
Kills
Repels
Kills
√
√
√
√
√
√
√
√†
√‡
Biting flies
Chewing lice
Repels
√
K9 Advantix® II works continuously for up to four weeks.
Ctenocephalides felis (12-week activity)
Ixodes scapularis, Demacentor variabilis, Rhipicephalus sanguineus (12-week activity);
Amblyomma americanum (8-week activity)
†
‡
K9 Advantix® II not only kills but also REPELS fleas, ticks and mosquitoes.
Oral products only kill, and the parasite must bite to die. K9 Advantix® II works
through contact. Fleas and ticks do not need to bite or attach to die.
20
K9 Advantix® II
kills fleas and
ticks through
contact with a
treated dog. Fleas
don’t have to bite
to die. Ticks don’t
have to attach
to die.
K9 Advantix® II vs Frontline® Plus
Frontline® Plus
K9 Advantix® II
Fleas
Ticks
Mosquitoes
Kills
Repels
Kills
√
√
√
√
√
√
√
√
√
Biting flies
Chewing lice
√
Repels
√
K9 Advantix® II vs Frontline® TriTak®
Frontline® TriTak®
K9 Advantix® II
Fleas
Ticks
Mosquitoes
Kills
Repels
Kills
√
√
√
√
√
√
√
√
√
Biting flies
Chewing lice
A recent study points
out that 60% of
surveyed dog
owners prefer
to use topical
flea and tick
prevention;
24% would prefer
an oral flea and
tick product. The
remainder use
treatment products
such as shampoos.*
√
Repels
√
K9 Advantix® II vs Parastar® Plus
Parastar® Plus
K9 Advantix® II
Fleas
Ticks
Mosquitoes
Kills
Repels
Kills
√
√
√
√
√
√
√
√
√
Biting flies
Chewing lice
√
Repels
√
*Pet owners were recruited from a nationally representative sample of U.S. households. Consumers were required to own a
dog, be at least 18 years of age, and be the primary decision maker regarding their pet’s health or pet products purchased.
Pet owners were asked what type of flea and tick product they would prefer to buy in the future.1
1
21
(continued)
K9 Advantix® II competitive profile (continued)
Activyl® Tick Plus repels ONLY TICKS.
K9 Advantix® II vs Activyl® Tick Plus
Activyl® Tick Plus
K9 Advantix® II
Kills
Repels
Kills
Repels
√
√
√
√
√
√
√
√
√
√
Fleas
Ticks
Mosquitoes
Biting flies
Chewing lice
K9 Advantix® II
has a total brand
awareness of
63%
√
among dog-only
households*
K9 Advantix® II vs Vectra 3D®
K9 Advantix® II vs Vectra 3D®: brand recognition
•• K9 Advantix® II is a well-recognized brand that clients may be likely to visit your clinic to buy
•• K9 Advantix® II has a total brand awareness of 63% among dog-only households
•• In comparison, Vectra 3D® has just 6% recognition*
Brand awareness for K9 Advantix® II = 63% among dog-only households
Vectra 3D® = only 6%
K9 Advantix® II has a small application volume
Dog Weight
Application
Volume
4–10 lbs
0.014 fl oz (0.4 mL)
11–20 lbs
0.034 fl oz (1.0 mL)
21–55 lbs
0.084 fl oz (2.5 mL)
Over 55 lbs
0.135 fl oz (4.0 mL)
K9 Advantix® II
40 lb
dog
Dog Weight
Application
Volume
2.5–20 lbs
0.054 fl oz (1.6 mL)
21–55 lbs
0.122 fl oz (3.6 mL)
56–95 lbs
0.159 fl oz (4.7 mL)
Over 95 lbs
0.270 fl oz (8.0 mL)
Vectra 3D®
45.2% more volume than K9 Advantix® II for
one monthly treatment on dogs weighing 21–55 lbs.
*Pet owners were recruited from a nationally representative sample of U.S. households. Consumers were
health or pet products purchased. Pet owners were asked which flea and tick products they could think of
or had ever heard of.1
22
1
Your clinic
depends
on client
satisfaction.
Carrying
K9 Advantix® II
can help keep
them coming
back.
23
(continued)
Supporting studies
K9 Advantix® II is well supported by hundreds of studies
Sample of published studies conducted using imidacloprid and/or permethrin:
Repel-and/or-kill (efficacy)
•• Cruthers L, Slone R, Arther RG, Davis W, Settje T. (2003). K9 Advantix (imidacloprid plus
permethrin) for controlling ticks and mosquitoes on dogs. Suppl Compend Contin Educ
Pract Vet. 25:15-18.
•• Dautel H, Kahl O, Siems K, Oppenrieder M, Muller-Kuhrt L, Hilker M. (1999). A novel test
system for detection of tick repellents. Entomol Exp Appl. 91(3):431-441.
•• Dautel H, Turberg A. (2003). The Moving-Object-Bioassay, a laboratory method
to determine the repellent efficacy of a permethrin and imidacloprid combination
(K9 Advantix). In: Proceedings of the 7th International Symposium on Ectoparasites
of Pets; April 13-16, 2003; League City, TX. 38.
•• Dryden MW, Payne PA, Smith V, Hostetler J. (2006). Efficacy of imidacloprid (8.8% w/w)
plus permethrin (44% w/w) spot-on topical solution against Amblyomma americanum
infesting dogs using a natural tick exposure model. Vet Ther. 7(2):99-106.
•• Dryden MW, Payne PA, Smith V, Hostetler J. (2006). Evaluation of an imidacloprid
(8.8% w/w)–permethrin (44.0% w/w) topical spot-on and a fipronil (9.8% w/w)–
(S)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult
Ixodes scapularis and Amblyomma americanum ticks on dogs. Vet Ther. 7(3):173-186.
•• Dryden MW, Payne PA, Smith V, Hostetler J. (2006). Evaluation of an imidacloprid (8.8%
w/w)–permethrin (44.0% w/w) topical spot-on and a fipronil (9.8% w/w)–(S)-methoprene
(8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Rhipicephalus
sanguineus and Dermacentor variabilis ticks on dogs. Vet Ther. 7(3):187-198.
•• Epe C, Coati N, Stanneck D. (2003). Efficacy of the compound preparation imidacloprid
10%/permethrin 50% spot-on against ticks (I. ricinus, R. sanguineus) and fleas (C. felis) on
dogs. Parasitol Res. 90(Suppl 3):S122-S124.
•• Hellmann K, Knoppe T, Krieger K, Stanneck D. (2003). European multicenter field trial on
the efficacy and safety of a topical formulation of imidacloprid and permethrin (Advantix)
in dogs naturally infested with ticks and/or fleas. Parasitol Res. 90(Suppl 3):S125-S126.
•• Mencke N. (2005). Acaricidal and repellent properties—treatment of dogs with
imidacloprid 10%/permethrin 50% spot-on solution. In: Proceedings of the 6th Bayer
Ectoparasite Symposium; BSAVA Congress 2005; Birmingham, UK. 18-23.
24
ticks
fleas
Supporting studies (continued)
•• Epe C, Coati N, Stanneck D. (2003). Efficacy of the compound preparation imidacloprid
10%/permethrin 50% spot-on against ticks (I. ricinus, R. sanguineus) and fleas (C. felis) on
dogs. Parasitol Res. 90(Suppl 3):S122-S124.
•• Genchi C, Traldi PG, Bianciardi PP. (2000). Efficacy of imidacloprid on dogs and cats with
natural infestations of fleas, with special emphasis on flea hypersensitivity.
Vet Ther. 1(2):71-80.
•• Hellmann K, Knoppe T, Krieger K, Stanneck D. (2003). European multicenter field trial
on the efficacy and safety of a topical formulation of imidacloprid and permethrin
(Advantix) in dogs naturally infested with ticks and/or fleas. Parasitol Res.
90(Suppl 3):S125-S126.
•• Hopkins TJ, Woodley I, Gyr P. (1997). Imidacloprid topical formulation: larvicidal effect
against Ctenocephalides felis in the surroundings of treated dogs. Suppl Compend Contin
Educ Pract Vet. 19(5):4-10.
•• Mehlhorn H, Mencke N, Hansen O. (1999). Effects of imidacloprid on adult and larval
stages of the flea Ctenocephalides felis after in vivo and in vitro application: a light- and
electron-microscopy study. Parasitol Res. 85(8-9):625-637.
•• Mehlhorn H. (2000). Mode of action of imidacloprid and comparison with other
insecticides (i.e., fipronil and selamectin) during in vivo and in vitro experiments. Suppl
Compend Contin Educ Pract Vet. 22(4A):4-8.
•• Rust M, Waggoner M, Mencke N, Hansen O, Vaughn M. (2002). Disruption of adult cat
flea feeding by imidacloprid. Suppl Compend Contin Educ Pract Vet. 24(4B):4-5.
mosquitoes
•• Cruthers L, Slone R, Arther RG, Davis W, Settje T. (2003). K9 Advantix (imidacloprid plus
permethrin) for controlling ticks and mosquitoes on dogs. Suppl Compend Contin Educ
Pract Vet. 25(5A):15-18.
•• Hayasaki M, Saeki H. (2009). Inhibition and prevention efficacy against mosquito
bloodsucking and Dirofilaria immitis infection by administration of topical insecticide.
J Vet Med Sci. 71(8):1049-1052.
•• Machida H, Kondo T, Kanehira K, Hagimori I, Kamio T. (2008). The inhibitory effect of
a combination of imidacloprid and permethrin on blood feeding by mosquitoes
in dogs raised under outdoor conditions. Vet Parasitol. 154(3-4):318-324.
25
(continued)
Supporting studies (continued)
•• Fourie LJ, Stanneck D, Horak IG. (2006). The efficacy of a topically applied combination
biting flies
of imidacloprid and permethrin against Stomoxys calcitrans on dogs.
Intern J Appl Res Vet Med. 4(1):29-33.
•• Hanssen I, Mencke N, Asskildt H, Ewald-Hamm D, Dorn H. (1999). Field study on the
insecticidal efficacy of Advantage against natural infestations of dogs with lice.
Parasitol Res. 85(4):347-348.
•• Stanneck D, Ketzis J, Doyle J, Fisher M. (2008). Lice management options: efficacy of
three imidacloprid-containing formulations against natural lice (Trichodectes canis)
infestations in dogs. Suppl Compend Contin Educ Vet. 30(6B).
Canine vector-borne diseases
•• Blagburn BL, Spencer JA, Billeter SA, et al. (2004). Use of imidacloprid-permethrin to
prevent transmission of Anaplasma phagocytophilum from naturally infected Ixodes
scapularis ticks to dogs. Vet Ther. 5(3):212-217.
•• Otranto D, de Caprariis D, Lia RP, et al. (2010). Prevention of endemic canine vector-borne
diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field
study. Vet Parasitol. 172(3-4):323-332.
•• Otranto D, Lia RP, Cantacessi C, et al. (2005). Efficacy of a combination of imidacloprid
10%/permethrin 50% versus fipronil 10%/(S)-methoprene 12%, against ticks in naturally
infected dogs. Vet Parasitol. 130(3-4):293-304.
•• Otranto D, Paradies P, Testini G, et al. (2008). Application of 10% imidacloprid/50%
permethrin to prevent Ehrlichia canis exposure in dogs under natural conditions.
Vet Parasitol. 153(3-4):320-328.
•• Otranto D, Testini G, Dantas-Torres F, et al. (2010). Diagnosis of canine vector-borne
diseases in young dogs: a longitudinal study. J Clin Microbiol. 48(9):3316-3324.
•• Spencer JA, Butler JM, Stafford KC, et al. (2003). Evaluation of permethrin and
imidacloprid for prevention of Borrelia burgdorferi transmission from blacklegged ticks
(Ixodes scapularis) to Borrelia burgdorferi-free dogs. Parasitol Res. 90(Suppl 3):S106-S107.
•• Young DR, Arther RG, Davis WL. (2003). Evaluation of K9 Advantix II vs. Frontline Plus
topical treatments to repel brown dog ticks (Rhipicephalus sanguineus) on dogs.
Parasitol Res. 90(Suppl 3):S116-S118.
Mode of action
•• Turberg A, Methfessel C. (2003). Electrophysiological studies demonstrate improved
effects with the combination of imidacloprid and permethrin in a pest arthropod.
J Vet Pharmacol Ther. 26(Suppl 1):191.
26
lice
27
REPELLENCY
SPEED OF KILL
BROAD SPECTRUM
CLINIC SUPPORT
• Order K9 Advantix® II
• Learn about our latest offers and promotions
• Request promotional material for your practice
• Inquire about product training
STUDIES & COMPARISONS
Contact your Bayer rep today.
Bayer provides solutions for
your pest prevention needs.
Product
Type of client
ticks Topical
mosquitoes
Monthly
fleas
biting flies
•Wants effective protection
against fleas, ticks, mosquitoes,
biting flies and lice
lice
• Compliant pet owner
fleas
fleas
fleas
fleas
ticks
leas
ffleas
ticks
flea
eggs
mosquitoes
flea larvae
biting
lice flies
• Satisfied with monthly flea &
tick topical treatments
lice
Do not use K9 Advantix® II on cats.
mosquitoes
biting flies
lice
flea
eggs
flea larvae
lice
ticks
flea eggs
flea larvae
ticks
fleas
ticks
lice
• Compliant pet owner
ticks
mosquitoes
ticks Topical
Monthly
fleas
ticks
ticksfleas
flea eggs
fleas
fleas
flea larvae
ticks
biting flies
• Satisfied with monthly flea
topical treatments
lice
mosquitoes
biting flies
ticks
fleas
flea eggs
8-Month
Collarflea larvae
ticks
fleas
ticks
fleas
mosquitoes
• Fleas are main concern
lice
• Uses fewer than 6 months of
treatments per year
lice
biting flies
lice
lice
•Prefers a longer duration
product than monthly
ticks
fleas
flea eggs
ticks flea larvae
fleas
Spray
ticks
lice
• Needs supplemental
tick treatment for
heavy tick burdens
ticks
We are continuously monitoring flea susceptibility
Each year, thousands of flea eggs are collected by a global network of veterinarians
who send samples to investigating laboratories for a three-step analysis. Their research
shows that fleas tested continue to remain susceptible to imidacloprid, one of the active
ingredients in K9 Advantix® II.
K9 ADVANTIX® II
Topical prevention and treatment of ticks, fleas, mosquitoes, biting flies and lice
for monthly use only dogs and puppies 7 weeks of age and older
READ THE ENTIRE LABEL BEFORE EACH USE
DO NOT USE ON CATS
For the Prevention and Treatment of Ticks, Fleas, Mosquitoes, Biting Flies and Lice on Dogs
· Repels and kills ticks including Deer ticks (vector of Lyme disease), American dog ticks (vector of
Rocky Mountain spotted fever), Brown dog ticks (vector of Ehrlichiosis), and Lone Star ticks (vector of
Ehrlichiosis) for up to four weeks
· Repels and kills all life stages of fleas
· Prevents fleas on treated dogs from infesting your home
· Kills fleas on dogs within 12 hours and continues to prevent infestations for a month
· Prevents development of fleas, flea eggs, pupae and larvae for a month
· Larval flea stages in the dog’s surroundings are killed following contact with a K9 Advantix® II treated dog
· Repels and kills mosquitoes for up to four weeks
· Repels and prevents blood-feeding by biting flies
· Waterproof
· 5-way protection against ticks, fleas, mosquitoes, biting flies and lice
· Kills chewing lice
ACTIVE INGREDIENTS:
% By Weight
Imidacloprid ........................................................................................................................................ 8.80 %
Permethrin*....................................................................................................................................... 44.00 %
Pyriproxyfen ........................................................................................................................................ 0.44 %
OTHER INGREDIENTS ...................................................................................................................... 46.76 %
TOTAL ................................................................................................................................................ 100.0 %
*cis/trans ratio: max 55% (±) cis and min 45% (±) trans
KEEP OUT OF REACH OF CHILDREN
WARNING
DIRECTIONS FOR USE
It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not
contaminate feed or food.
HOW TO OPEN
1. Be sure tube is at bottom of pouch.
2. Using scissors, cut the pouch across the top and remove tube.
HOW TO APPLY
1. Use only on dogs.
DO NOT USE ON CATS or on other animals. Do not apply to dogs weighing less than 4 lbs.
2. Remove applicator tube from the package. Use scissors and peel down foil.
3. Hold applicator tube in an upright position. Pull cap off tube.
may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.
Larval flea stages in the dog’s surroundings are killed following contact with a K9 Advantix® II treated dog.
K9 Advantix® II is waterproof and remains effective following a shampoo treatment, swimming or after
exposure to rain or sunlight.
Monthly treatments are required for optimal control and prevention of fleas and ticks.
For dogs over 55 lbs., do not apply more than 1 tube per treatment
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS
WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on skin or clothing. Harmful if
swallowed. Harmful if absorbed through skin. Avoid contact with skin. Wash thoroughly with soap and water after
handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash
contaminated clothing before reuse.
HAZARDS TO DOMESTIC ANIMALS
For external use on dogs only. Do not use on animals other than dogs. Do not use on puppies under
seven weeks of age or weighing less than 4 lbs.
Do not get this product in dog’s eyes or mouth. As with any product, consult your veterinarian before using this
product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rare, may occur after
using ANY pesticide product for dogs. If signs persist, or become more severe, consult a veterinarian immediately.
If your animal is on medication, consult your veterinarian before using this or any other product.
Side Effects
Monitor your dog after application, Side effects, although very rare, may include signs of skin irritation such as
redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been
reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 1-800-422-9874.
DO NOT USE ON CATS – MAY BE FATAL.
Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat
contact your veterinarian immediately.
For consumer questions call 1-800-255-6826.
For medical emergencies call 1-800-422-9874.
ENVIRONMENTAL HAZARDS
This product is extremely toxic to acquatic organisms, including fish and invertebrates. Do not add directly
to water. Do not contaminate water when disposing of product or packaging.
FIRST AID
• Hold eye open and rinse slowly and gently with water for 15–20 minutes. Remove
contact lenses, if present, after the first 5 minutes, then continue rinsing eye.
• Call a poison control center or doctor for treatment advice.
If swallowed: • Call poison control center or doctor immediately for treatment advice. Have person
sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by
the poison control center or doctor.
• Do not give anything by mouth to an unconscious person.
If on skin
• Take off contaminated clothing.
or clothing:
• Rinse skin immediately with plenty of water for 15–20 minutes.
• Call a poison control center or doctor for treatment advice.
HOTLINE NUMBER
Have the product container or label with you when calling a poison control center or doctor, or going for
treatment. You may also contact 1-800-422-9874 for emergency medical treatment information. For
consumer questions call 1-800-255-6826.
NOTE TO PHYSICIAN
Treat the patient symptomatically.
If in eyes:
STORAGE AND DISPOSAL
4. Turn the cap around and place other end of cap back on tube.
5. Twist cap to break seal, then remove cap from tube.
6. The dog should be standing for easy application. The entire contents of the K9 Advantix® II tube should be
applied evenly to two to three spots on the top of the back from the shoulder to the base of the tail. At each
spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel
a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that
could cause some of the solution to run off the side of the dog.
Do not get this product in your dog’s eyes, or allow your dog to ingest this product.
4-10 lbs.:
11-20 lbs.:
3 2 1
3 2 1
21-55 lbs.:
Over 55 lbs.:
6 The dog should be standing for easy application. The entire contents of the K9 Advantix II tube should be
applied evenly to four to six spots on the top of the back from the shoulder to the base of the tail. At each
spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a
portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could
cause some of the solution to run off the side of the dog.
Do not get this product in your dog’s eyes, or allow your dog to ingest this product.
7. Discard empty tube as described in Storage and Disposal.
8. In cases of severe pest infestations, retreatment is allowable earlier than four (4) weeks. Do not retreat more
often than once every seven (7) days. After pest control is attained, return to a monthly retreatment schedule.
PRODUCT INFORMATION
The successive feeding activity of fleas on dogs may elicit a hypersensitivity skin disorder known as flea
allergy dermatitis (FAD). Treatment of dogs with K9 Advantix® II rapidly kills fleas and may reduce the
incidence of this condition.
K9 Advantix® II kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with
protection against further flea infestation lasting at least four (4) weeks. Pre-existing pupae in the environment
®
Do not contaminate water, food or feed by storage or disposal.
Storage: Store in a cool, dry place. Protect from freezing.
Pesticide Disposal and Container Handling: Nonrefillable container.
If empty: Do not reuse this container.
Place in trash or offer for recycling, if available.
If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. Never
place unused product down any indoor or outdoor drain.
LIMITED WARRANTY AND LIMITATION OF DAMAGES
Bayer HealthCare LLC, Animal Health Division warrants that this material conforms to the chemical description on the
label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER MAKES NO OTHER EXPRESS OR IMPLIED
WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY,
and no agent of Bayer is authorized to do so except in writing with a specific reference to this warranty. To the extent
consistent with applicable law, any damages arising from a breach of this warranty shall be limited to direct damages
and shall not include consequential commercial damages such as loss of profits or values, etc.
Manufactured For
Bayer HealthCare LLC, Animal Health Division,
P.O. Box 390, Shawnee Mission, Kansas 66201 USA
Bayer, the Bayer Cross and K9 Advantix are registered trademarks of Bayer
© 2013 Bayer HealthCare LLC
Made in Germany
K9 Advantix II is protected by the following U.S. patents: 6,232,328 and 7,728,001
K9 ADVANTIX II small dog - dogs and puppies 7 weeks of age and older and weighing 4-10 lbs.
Four 0.014 fl oz (0.4 mL) Tubes
81293651
Six 0.014 fl oz (0.4 mL) Tubes
EPA Est. No. 11556-DEU-1
EPA Reg. No. 11556-141
K9 ADVANTIX II medium dog - dogs and puppies 7 weeks of age and older and weighing 11 - 20 lbs.
81294100
EPA REG. NO. 11556-142
K9 ADVANTIX II large dog - dogs and puppies 7 weeks of age and older and weighing 21 - 55 lbs.
81294135
EPA Reg. No. 11556-143
K9 ADVANTIX II extra large dog - dogs and puppies 7 weeks of age and older and weighing over 55 lbs.
81294224
EPA Reg. No. 11556-144
19177
No matter how many clients come through your door,
only the satisfied ones will continue to put their trust in
you time and time again.
A perfect fit for client satisfaction
There are a lot of options out there,
but K9 Advantix® II delivers a unique
combination of benefits – from a repel-and-kill
mode of action to ongoing clinic support – to
help keep your clients satisfied.
Weight
Weight
11–
20 lbs
21–
55 lbs
Weight
Weight
4–
10 lbs
55 lbs
Over
Do not use K9 Advantix® II on cats.
Learn more at www.BayerDVM.com
©2015 Bayer HealthCare LLC, Animal Health, Shawnee Mission, Kansas 66201
Bayer (reg’d), the Bayer Cross (reg’d), Advantage,® K9 Advantix,® Resultix,®
Seresto® and for the love of dog™ are trademarks of Bayer.
Frontline, NexGard and TriTak are registered trademarks of Merial.
Vectra 3D is a registered trademark of Ceva Animal Health, LLC.
Activyl and Bravecto are registered trademarks of Intervet Inc., a subsidiary of Merck & Co.
Parastar is a registered trademark of Novartis AG.
K15008

K9 Advantix II Master TOTAL FILE SIZE

Transcription

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