Program 2007 - World Conference on Regenerative Medicine

Program
October 18–20, 2007
Germany | Congress Center Leipzig
3rd WORLD CONGRESS ON
REGENERATIVE MEDICINE
New Products for Diagnostics and Therapy
www.regmed.org
© N. zur Nieden: Hanging drops for stem cell cultivation
TRM
Leipzig
You would like to realise your ideas of research
in the area of regenerative medicine?
We are pleased to meet you!
Translational Centre for Regenerative Medicine
(TRM-Leipzig)
Molecules and Cells in Tissue Regeneration
From Concept to Clinical Application
The mission of the TRM-Leipzig is to conduct and support interdisciplinary
research for regenerative medicine. We provide an effective link between
academia, research institutions, and small- and medium-sized biotechnology
companies. Our task is to translate conceptual research into clinical practice
and to develop and train internationally competitive basic and clinical scientists.
3rd World Congress on Regenerative Medicine
October 18–20, 2007
Congress Center Leipzig, Germany
Organizer
Fraunhofer Institute for Cell Therapy and Immunology,
Leipzig
You will find us at floor 1 opposite lecture hall 1
Welcome to our TRM – Session
on 3rd World Congress on Regenerative Medicine
- Space Medicine Meets Regenerative Medicine Saturday, October 20, 2007
11.00 am - 12.30 pm
01.30 pm - 03.00 pm
lecture hall 1
In Cooperation with:
Translational Centre for
Regenerative Medicine
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Saxony State Ministry for
Economic Affairs and Labor
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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WELCOME ADDRESS
BURKHARD JUNG
WELCOME ADDRESS
FRANK EMMRICH
I warmly welcome you to the 3rd World Congress on Regenerative
Medicine in the Congress Center Leipzig. For the third time, researchers
and industry are coming together in the context of this
international event.
The Free State of Saxony and Leipzig in particular play a
crucial role in the development of regenerative medicine in
Germany. In Leipzig,
the strengths are many-fold: the high-level infrastructure in the field of medical
sciences; the prestigious medical faculty of the Universität Leipzig; three Max-PlanckInstitutes; one of the five faculties for veterinary medicine in Germany and a renowned
Cardiac Center. Additionally, the BIOCITY as a biotechnological and biomedical centre,
houses several companies and institutions.
One of the latest institutions, founded in April 2005, which has its focus on regenerative
medicine is the Fraunhofer-Institute for Cell Therapy and Immunology (IZI) which is also
the organizer of this World Congress.
The establishment of the Fraunhofer-Institute was a critical step on the way to
developing a regional focus on regenerative medicine in Leipzig. A unique strength of
the region is the growing expertise in the translation of basic research into the clinic.
Almost one year ago, Leipzig won special funding through a national competition for
a centre for regenerative medicine that was initialized by the “Bundesministerium
für Bildung und Forschung” (Federal Ministry of Education and Research, BMBF). The
Translational Centre for Regenerative Medicine was opened in October 2006 under the
direction of Prof. Frank Emmrich. The Centre unites institutes of over five faculties
from the Universität Leipzig, many non-academic research institutions, as well as local
small- and medium-sized industrial partners.
These facts demonstrate the importance of Leipzig as a scientific centre. Events such
as the 3rd World Congress on Regenerative Medicine strengthen and underline this
fact.
Participants of this large-scale event are traveling from all across the globe and
will be able to see and experience regenerative medicine first-hand in Leipzig. If you
have the chance to go on a sight-seeing tour through Leipzig, don’t miss the amazing
and unique places, buildings and the charming atmosphere of the city and its centre.
Museums, such as the Museum of Fine Arts, the opera, theatre or cabaret offer you
many possibilities to enjoy an exciting stay in Leipzig.
I hope that this congress will be a very successful one for each of you with much to
learn, to hear, to discuss and to use for your prospective work. In addition to the scientific exchange, I trust you will keep in mind the city of Leipzig with its many facets.
After the positive responses in the wake of the first World
Congress on Regenerative Medicine in 2003, followed by the
second – even larger – second WCRM in 2005, Leipzig is
proud to be host for the third WCRM in 2007 again.
The congress offers an international forum for researchers and industrials from tissue
engineering to nanomedicine to meet and discuss new developments in the rapidly
growing field of regenerative medicine.
Representatives from many countries will gather to present their latest findings in
the fields of stem cells, umbilical cord cells, cartilage and bone repair, neuro-regeneration, immunology, skin and soft tissue repair as well as tissue engineering, scaff olds
and imaging. Discussion and exchange of information on these topics will extend from
academia to industry. Additionally numerous sponsors and exhibitors from biotech to
pharma will present new technologies and in this contribute to the important conversation between science and industry.
The infrastructure for Regenerative Medicine in Leipzig, which is key for the success
of this event, is still growing, for example over the next 5 years the German granting
agency (BMBF) is funding Leipzig researchers for a minimum of 11 Mio euros annually.
Some of the institutes which are beneficiaries include Biotechnical and Biomedical
Centre (BBZ) of the University of Leipzig, the new Translational Centre for Regenerative
Medicine (TRM) as well as the Fraunhofer Institute for Cell Therapy and Immunology
(IZI), who is proud to be the organizer of the 3rd WCRM.
Leipzig itself was famously called “little Paris” by the renowned poet Johann Wolfgang
von Goethe who lived here for many years, and no visit would be complete without a
tour through the old city with its charming architecture and lovely atmosphere.
I am delighted to welcome you to Leipzig for the 3rd World Congress on Regenerative
Medicine and I wish all of us interesting and fruitful days with top-class presentations,
exciting discussions and positive impressions not only of the congress but also of
Saxony and one of its brightest jewels – Leipzig.
Professor Frank Emmrich, Conference President
Burkhard Jung, Lord Mayor of Leipzig
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TABLE OF CONTENTS
Scientific board and local organizing commitee
9
Overview congress venue
10–11
Program at a glance
12–13
2 nd Fraunhofer Life Science Symposium Leipzig 2007 –
Your best solution for precise results
Tissue Regeneration in Veterinary Medicine
14–15
Thursday, October 18, 2007
16–21
Friday, October 19, 2007
22–30
Saturday, October 20, 2007
32–37
Overview poster exhibition
Thermo Fisher Scientific Inc. is the world leader in serving science, enabling our customers to make the world
healthier, cleaner and safer.
3rd World Congress on
Regenerative Medicine
Floor +1, booth 38
From routine testing to complex research and discovery,
the industry-leading instruments answer "what is it" and
"how much is there". Thermo Fisher Scientific helps tackle tough analytical challenges using advanced technologies ranging from mass spectrometry and elemental
analysis to chromatography, molecular spectroscopy,
and microanalysis.
Thermo Scientific offers customers a complete range of
high-end analytical instruments as well as laboratory
equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions.
38
Posters
39–49
Evening functions
50–51
Sponsors & Exhibitors
52–53
Exhibition plans
54–55
General information
56–57
How to get to the Congress Center Leipzig
59
Editorial deadline: October 5, 2007
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OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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www.pH1.de
SCIENTIFIC BOARD
Tie up to
Achievements!
In Leipzig, biotechnology is given top priority.
Proof for this: the new BIO CITY LEIPZIG.
● Where industry, science and research live
and work together.
● Where knowledge is not only shared
but multiplied.
● Where young companies and the
University of Leipzig set new standards in
biotechnology.
● Where you find uniquely favourable
conditions.
www.bio-city-leipzig.de
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Barthel, Henryk
University of Leipzig, Germany
Bulte, Jeff
The Johns Hopkins University School of Medicine,
Baltimore, MD, USA
Emmrich, Frank
Fraunhofer Institute for Cell Therapy and Immunology,
Leipzig, Germany
Engel, Wolfgang
Georg-August-Universität, Göttingen, Germany
Hasenfuß, Gerd
Georg-August-Universität, Göttingen, Germany
Hengstler, Jan G.
University of Leipzig, Germany
Hutmacher, Dietmar W.
Queensland University of Technology, Kelvin Grove, Australia
Kerr, Douglas
Johns Hopskins TM Center, Baltimore, MD, USA
Lin, Feng-Huei
Institute of Biomedical Engineering, National Taiwan University,
Tapei, Taiwan
Mason, Chris
University College London, UK
Mertsching, Heike
Fraunhofer Institute for Interfacial Engineering and
Biotechnology (IGB), Stuttgart, Germany
Mol, Anita
Eindhoven University of Technology, The Netherlands
Orive, Gorka
University of the Basque Country, Vitoria, Spain
Pfützner, Andreas
Institute for Clinical Research and Development (IKFE),
Mainz, Germany
Sykova, Eva
Institute of Experimental Medicine, Prague, Czech Republic
Temiz Artmann, Aysegül
Institute of Bioengineering, University of Applied Sciences
Aachen, Germany
Williams, David
Loughborough University, UK
LOCAL ORGANIZING COMMITEE
Einspanier, Almuth
Faculty of Veterinary Medicine, University of Leipzig, Germany
Emmrich, Frank
Fraunhofer Institute for Cell Therapy and Immunology
Faber, Sonya
Fraunhofer Institute for Cell Therapy and Immunology
Gerdes, Wilhelm
Fraunhofer Institute for Cell Therapy and Immunology
Oechtering, Gerhard
Faculty of Veterinary Medicine, University of Leipzig, Germany
Seeger, Johannes
Faculty of Veterinary Medicine, University of Leipzig, Germany
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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OVERVIEW CONGRESS VENUE
Floor 0
Elevator
Catering
Lecture Hall 3
Exhibition area
Catering
Foyer
Exhibition area
Exhibition area
Speaker
Preview
Elevator
Elevator
Catering
Exhibition area
Exhibition area
Floor –1
Floor +1
Lecture
Hall 4
Lecture
Hall 5
Elevator
Elevator
Catering
Elevator
Elevator
Lecture Hall 1
Counter, Check-in
Foyer
Lounge
Catering
Foyer West
Foyer Ost
Poster exhibition
Exhibition area
Exhibition area
Entrance
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PROGRAM AT A GLANCE
O C T O B E R 17, 2 0 0 7
7:30 pm
SPECI A L DINNER LEC T URE AT THE OLD S TOCK E XCH A NGE
OCTOBER 18, 2007
9:00–10:30 am
R O O M 10
Stem Cell Technology in Mammals
10:30–11:00 am
C O F F E E B R E A K / B R E A K FA S T
HALL 5
p. 14 Thermo Fisher Scientific –
Partner of Regenerative Medicine Research –
Brunch Symposium
Immunology and Vaccines in Veterinary Medicine
p. 15
11:00 am–12:15 pm
p. 17
HALL 4
Symposium
p. 18
GRM – German Society for Regenerative Medicine
Why invest in an innovative field?
HALL 1
REGENERATE
General Assembly of the European Network for
Regenerative Medicine EEIG
p. 18 (ROOM 9)
HALL 3
Bioengineering of Soft Tissue Membranes p. 20
Progenitor Cell Therapy, LLC –
Industry Symposium
Stem Cell and Tissue Bioengineering
OPENING CEREMONY
1:00–2:00 pm
L U N C H (12 :15 –1: 0 0 p m)
2:00–3:30 pm
Tissue Engineering in Veterinary Medicine
3:30–4:00 pm
4:00–5:30 pm
COFFEE BREAK
Cell Therapy in Veterinary Medicine
5:30 pm
G E T-T O G E T H E R I N T H E E X H I B I T I O N A R E A | P O S T E R S E S S I O N ( 5 : 3 0 –7: 3 0 P M)
p. 15 Industry Technology: Industry Insights and
Strategic Direction
p. 17
Immunologic Tissue Acceptance
p. 18 Stem Cells in Diabetes
p. 15 New Industrial Technology Platform
p. 18
Symposium
p. 19 Stem Cells: Cardiac
ESAO – European Society of Artificial Organs
Towards Bioartificial Organs
p. 20
p. 19
p. 19 Biophysics in Cell and Tissue Research
p. 21
p. 20 Symposium
p. 21
ISAC – International Society for Analytical Cytology
Cytometry – A Key Technology in Regenerative
Medicine
O C T OBER 19, 2 0 0 7
HALL 1
Stem Cells: Emerging Developments
HALL 4
p. 23 Vascular Remodelling and Angiogenesis
p. 25
HALL 5
Cartilage and Bone Engineering
HALL 3
p. 27 Stem Cells: Neuronal
10:30–11:00 am
11:00 am–12:30 pm
COFFEE BREAK
Law for hESC Research, Reimbursment, Ethics and
Advanced Therapy Products
p. 23 Metabolism in Regenerative Medicine
p. 25
Biomaterials and Scaffolds for Regeneration I
p. 27 NanoMicrostructures in Diagnostics, Therapy and
Therapeutic Monitoring
p. 29
12:30–1:30 pm
1:30–3:00 pm
LUNCH BREAK
Embryonic Stem Cells
p. 24 Tissue Engineering I
p. 26
Symposium
ESOT – European Society for Organ Transplantation
Stem Cell Transplantation and Immunomodulation
p. 28 NanoMicrostructures in Diagnostics, Therapy and
Therapeutic Monitoring: Neuroperspectives
p. 30
3:00–3:30 pm
3:30–5:00 pm
COFFEE BREAK
Pluripotency and Gamete Derived Stem Cells
p. 24 Symposium
ETCS – European Tissue Culture Society
Stem Cells and Tumorigenesis
p. 26
Stem Cells: Liver
p. 28 Innovative Methods and Drug Delivery Technologies
p. 30
5:00–6:30 pm
Regulatory Affairs in Advanced Therapy Products
p. 24 Pluristem Life Systems, Inc.
p. 26
Placental Cells in Cell Therapy Industry Symposium
Immunologic Issues in Regenerative Medicine
p. 28 Imaging of Regeneration I
p. 30
8:00 pm
S O C I A L E V E N I N G AT M O R I T Z B A S T E I
HALL 4
p. 33 Symposium
ICRS – International Cartilage Repair Society
How to Reconstruct Injured Cartilage
p. 34
HALL 1
Biomaterials and Scaffolds for Regeneration II
HALL 5
p. 35 Neurodegeneration and Repair
p. 36
8:30–10:30 am
p. 29
OCTOBER 20, 2007
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8:30–10:00 am
R O O M 11
Medical Applications of ncRNA
10:00–11:00 am
11:00 am–12:30 pm
COFFEE BRE AK | POSTER SESSION | POSTER AWARD
Medical Applications of ncRNA, continued
p. 33 Materials, Surfaces and Implants
p. 34
Space Medicine Meets Regenerative Medicine
p. 36 Signal Transduction in Regeneration
p. 37
12:30–01:00 pm
01:00–02:30 pm
LUNCH BREAK
Clinical Studies in Cell Therapy and Tissue Engineering p. 33 Tissue Engineering II
p. 35
Space Medicine Meets Regenerative Medicine, continued
p. 36 Imaging of Regeneration II
p. 37
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Thursday, October 18
2nd Fraunhofer Life Science
Symposium Leipzig 2007
Thursday, October 18
11:00 am–12:15 pm
Immunology and Vaccines in Veterinary Medicine
Chair: S. Ulbert
> keynote
L. Hellmann
Vaccination against IgE – a potential treatment strategy against canine atopic
dermatitis
Tissue Regeneration in Veterinary
Medicine
12:15–1:00 pm
THURSDAY
> keynote
G. Alber
Triggering immune reactions by vaccination
Lunch break
2:00–3:30 pm
Tissue Engineering in Veterinary Medicine
Chair: W. Brehm
> keynote
W. Brehm
Equine mesenchymal stem cells for the treatment of tendinous lesions in the horse
> keynote
J. Hubbell
Biomaterial scaffold approaches for morphogen delivery
S. Giovannini
Multilineage potential of equine blood-derived fibroblast-like cells
W. Brehm
Influence of co-culture on the formation of hyaline cartilage in vitro in a 3-D system
with equine chondrocytes and autologous equine bone marrow mesenchymal stem
cells
3:30–4:00 pm
Coffee break
R O O M 10
9:00–10:30 am
Stem Cell Technology in Mammals
Chair: A. Einspanier
N. zur Nieden
Primate embryonic stem cells
> keynote
N. Jeffery
Intraspinal transplantation of olfactory ensheathing cells for severe spinal cord
injury in the dog
R. Revoltella
Primate embryonic stem cells create their own niche while differentiating in threedimensional culture systems
H. Gabr
Stem cell therapy for acute spinal cord injury in dogs
> keynote
J. Plendl
Vascular stem cells in the bovine ovary
> keynote
W. Kues
Derivation of stem cells from farm animals and rodents: programming and
reprogramming of somatic cells
10:30-11:00 am
14
4:00–5:30 pm
Cell Therapy in Veterinary Medicine
Chair: T. Flegel
> keynote
L. Behr
Intra renal arterial administration of autologous mesenchymal stem cells (MSC) in
an ovine model of ischemia reperfusion injury results in kidney engraftment by MSC
without differentiation and functional or morphological improvement
H. Thissen
Micro arrays, stem cell-surface interactions and germ cell transplantation
Coffee break
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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16
HALL 5
9:00 am–12:30 pm
Thermo Fisher Scientific – Partner of Regenerative Medicine Research –
Brunch Symposium
THURSDAY
G E T-T O G E T H E R I N T H E E X H I B I T I O N A R E A | P O S T E R S E S S I O N
K.-G. Hoppmann
Thermo Fisher Scientific – Competent Partner of Regenerative Medicine Research
– Overview
S. Scory
Staying on target with siRNA: Using siRNA tools of optimized specificity for screening
and for therapeutic approaches
G. Kohla
Mag(net)ic purification of DNA – principles of DNA purification using magnetic beads
and the KingFisher
W. Glück
Perfection for safety – a new generation of Biological Safety Cabinets
10:45–11:00 am
Coffee break
A. Kamath
The utility of multipotent cord blood unrestricted somatic cells
E. Schwander
Expansion of adherent mammalian cells - From research bench to industrial
applications – A brief overview on disposable solutions and their use within
therapeutic approaches
* bioreactor presentation in session
W. Glück
Cell culture without compromise – How to minimize the risk of contamination in CO2Incubators
5:30–7:30 pm
Stem Cells: Cardiac
Symposium*
ESAO – European Society of
Artificial Organs
Towards Bioartificial Organs
New Industrial Technology
Platform*
4:00–
5:30 pm
3:30–4:00 pm
Cell Therapy in Veterinary
Medicine
COFFEE BREAK
Symposium
ISAC – International Society
for Analytical Cytology
Biophysics in Cell and Tissue
Research
Stem Cells in Diabetes
Industry Technology: Industry Immunologic Tissue
Acceptance
Insights and Strategic
Direction
2:00–
3:30 pm
OPENING
CEREMONY
1:00–2:00 pm
11:00 am–
12:30 pm
Immunology and Vaccines in
Veterinary Medicine
Thermo Fisher Scientific –
Partner of Regenerative
Medicine Research –
Brunch Symposium
Tissue Engineering in
Veterinary Medicine
Bioengineering of Soft Tissue
Membranes
Thursday, October 18
Stem Cell and Tissue
Bioengineering
HALL 3
HALL 1
REGENERATE
General Assembly of the
European Network for
Regenerative Medicine EEIG
( R O O M 9)
HALL 4
R O O M 10
Stem Cell Technology in
Mammals
9:00–
10:30 am
OCTOBER 18, 2007
HALL 5
Symposium
GRM – German Society for
Regenerative Medicine e.V.
Progenitor Cell Therapy, LLC –
Industry Symposium
Thursday, October 18
Overview
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
2:00–3:30 pm
Industry Technology: Industry Insights and Strategic Direction
Chair: V. Ronfard
> keynote
D. Williams
Regulated manufacturing of emerging cell and tissue based therapies
M. Lysaght
Recovery and growth of private-sector tissue engineering and regenerative medicine
during the past five years
Z. Aberman (Pluristem Life Systems, Inc.)
Placental 3D mesenchymal stem cells – A source for regenerative medicine
W. Rüdinger (Cytonet GmbH & Co. KG)
Regulatory frame for cell therapeutic approaches in light of the German tissue law
and the EU directives
3:30–4:00 pm
Coffee break
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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Thursday, October 18
Thursday, October 18
HALL 5
3:30-4:00 pm
> keynote
V. Ronfard (Organogenesis Inc.)
Development of collagen based biomaterials
I. Otte-Höller (LEICA-Mikrosysteme Vertrieb GmbH)
Laser microdissection – Applications of live cell cutting
F. Ylera (AbD Serotec)
Rapid generation of monoclonal antibodies using in vitro selection technology
S. Arain (PreSens Precision Sensing GmbH)
Non-invasive online-monitoring of oxygen and pH in cell cultivation
T. Jones (Antitope Ltd.)
Therapeutic antibodies without helper T cell epitopes
HALL 4
9:00–10:30 am
Why invest in an innovative field?
Symposium organised by German Society for Regenerative Medicine (GRM e. V.)
Chair: T. Skutella
W. Brech
Advanced Asset Management AG Deutschland, Frankfurt/Main
F. Mettler
GMF Beteiligungsberatungs GmbH, Frankfurt/ Main
E. Lampeter
Vita 34 AG, Leipzig
11:00 am–12:30 pm
Progenitor Cell Therapy, LLC – Industry Symposium
S. Craig
Developing cell therapies for commercial success
2:00–3:30 pm
Immunologic Tissue Acceptance
Chairs: J. Lehmann, M. Seifert
> keynote
H. Waldmann
Regulation and privilege in the long-term acceptance of allografts
> keynote
T. Gilbert
The host response to biologic scaffold materials
K. Kretschmer
De novo generation of regulatory T cells and Foxp3-dependent gene regulation
A. C. Zenclussen
Treg-dependent tolerance mechanisms during murine pregnancy
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4:00–5:30 pm
Towards Bioartificial Organs
Symposium organised by the European Society for Artificial Organs (ESAO)
Chairs: B. H. Walpoth, A. Bader
D. Falkenhagen
Cell Apheresis – present stage and future developments
B. Glasmacher
Cryopreservation of cell-seeded scaffolds
M. H. J. Maathuis
New machine perfusion technques for preservation and transportation of donor
organs
B. H. Walpoth
Cellular remodelling of biodegradable vascular grafts
A. Bader
Preclinical and clinical results in bone/cartilage engineering with bioreactors
THURSDAY
4:00–5:30 pm
New Industrial Technology Platform
Chairs: D. Williams, G. Schmiedeknecht
Coffee break
HALL 1
1:00–2:00 pm
OPENING CEREMONY
Welcome addresses
> Frank Emmrich, Head of Fraunhofer Institute for Cell Therapy and Immunology
> Bernat Soria Escoms, Minister of Health and Consumer Affairs of Spain
> Klaus Theo Schröder, State Secretary from the German Federal Ministry Health and
social security
> Peter Lange, Head of Department of Research and Health from the German Federal
Ministry of Education and Research
G. MacKay (Organogenesis Inc.) > keynote
Learning from the development of a cell-based business model
2:00–3:30 pm
Stem Cells in Diabetes
Chairs: G. Orive, B. Stratmann
> keynote
B. Soria
Cell therapy of diabetes and its complications
> keynote
B. Stratmann
Therapeutic potential of stem cells for ischemic wounds in diabetes mellitus
> keynote
Y. Reisner
Embryonic pig pancreatic precursor tissue as a potential source for transplantation
in type 1 diabetes
3:30–4:00 pm
Coffee break
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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Thursday, October 18
Thursday, October 18
HALL 1
P. Linder, E. Kurulgan, A. Robitzki, G.M. Artmann
HP Bioforce: High-throughput cell culturing for cell and tissue research
A. Pfützner
Differentiation of adipocyte-derived adult mesenchymal stem cells into insulin
expressing cells in vitro
K. Guan
Spermatogonial stem cells for cardiac regeneration
A. Linke
Activation of cardiac progenitor cells by growth factors and exercise training
J. Li
ERa is expressed in cardiac stem cells and supports self-renewal after cardiac
ischemic injury in rat
H. Aupperle
Injection of autologous mesenchymal bone-marrow derived stem cells in rabbits with
chronic doxorubicin cardiomyopathy results in functional and histomorphological
alterations of the cardiac extracellular matrix
I. Digel, G. M. Artmann
Protein dynamics in thermosensation
K. F. Zerlin
Temperature transitions in haemoglobin and other globular proteins
A. Stadler, I. Digel, G.M. Artmann, G. Büldt, J. Zaccai
Dynamics and interactions of haemoglobin in human red blood cells and concentrated
haemoglobin solutions
P. Kleinbongard
RBC NO-synthase and its effects in cell function and cell-cell interaction
HALL 3
9:00–10:30 am
Bioengineering of Soft Tissue Membranes
Chairs: M. Staat, G. Hüttmann
M. Valter, A. Temiz Artmann
Differential overexpression of MMP-9 and mechanical inhomogeneity of the
chorioamniotic sac during premature rupture of the membranes
M. Staat, M. Topcu, S. Sponagel
Mechanical modelling and testing of biological membranes
M. Kemmerich, G. Antweiler, A. Temiz Artmann, P. Linder
Mechanics and structure of amniotic sac tissue as potential information to predict
premature birth
G. Hüttmann
Optical coherence tomography and its applications in biotechnology and regenerative
medicine
J. Trzewik, P. Meier
The changing nature of medical product development through “Open Innovation”
11:00 am–12:30 pm
Stem Cell and Tissue Bioengineering
Chairs: J. Hescheler, P. Lelkes
E. Tobiasch
The differentiation potential of human mesenchymal stem cells
J. Hescheler
Embryonic stem cells for bioengineering in regenerative medicine
P. I. Lelkes, M. J. Mondrinos, S. Koutzak, C.M. Finck
Engineering of vascularized distal pulmonary tissue constructs in vitro and in vivo
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2:00–3:30 pm
Biophysics in Cell and Tissue Research
Chairs: G. M. Artmann, G. Dikta
THURSDAY
4:00–5:30 pm
Stem Cells: Cardiac
Chairs: G. Steinhoff, J. Li
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
G. Dikta
Statistical change-point analysis
3:30–4:00 pm
Coffee break
4:00–5:30 pm
Cytometry – A Key Technology in Regenerative Medicine
Symposium organised by the International Society for Analytical Cytology (ISAC)
Chair: R. F. Murphy
R. F. Murphy
Identifying subtle changes in cell phenotypes using automated microscopy and
machine learning: Implications for Regenerative Medicine
J. Szöllösi
Biophysics of ErbB2 signaling
R. M. Zucker
Morphology and apoptosis in thick tissues using a confocal microscopy
A. Tárnok
Cytomics for regenerative medicine
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
21
22
Friday, October 19
8:30–10:30 am
Stem Cells: Emerging Developments
Chairs: D. Hutmacher, A. Stolzing
> keynote
Y. Barrandon
Potential of squamus epithelial cells in regenerative medicine
R. L. Bartel (Aastrom Biosciences)
Autologous stem cell therapies: Human clinical experience
H. J. Meisel
Nucleus pulposus regeneration using fresh autologous adipose-derived cells
FRIDAY
S O C I A L E V E N I N G AT M O R I T Z B A S T E I
G. Thumann
Tissue-engineered biodegradable pigment epithelial cell sheets for transplantation to
the subretinal space
R. Revoltella
Human CB-CD.133+ cells injected into NOD-SCID mice made deaf after ototoxic
treatment provide cenditions for the resumption of the inner ear structure and
function
A. Hartmann
Stem cell markers of the human hair follicle- characterization of a tissue engineered
reconstruct based on plucked hairs compared to human scalp
10:30–11:00 am
Coffee break
* bioreactor presentation in session
11:00 am–12:30 pm
Law of hESC Research, Reimbursement, Ethics, and Advanced Therapy
Products
Chair: S. Schilling, E. Falkner
> keynote
C. Mason
Regenerative Medicine 2.0: No longer lost in translation
D. Bühler (Maiwald Patentanwalts GmbH)
Patenting of stem cells in Europe
Y. Joly
Open approaches in regenerative medicine
N. K. Hafezi
Maximizing resources and assessing fundraising potential to sustain research centers
12:30–1:30 pm
Lunch break
8:00 pm
Imaging of Regeneration I
Immunologic Issues in Regenerative
Medicine
Regulatory Affairs in Advanced
Therapy Products
5:00–
6:30 pm
Innovative Methods and Drug Delivery
Technologies
Stem Cells: Liver*
Symposium
ETCS – European Tissue Culture
Society
Stem Cells and Tumorigenesis
Pluristem Life Systems, Inc.
Placental Cells in Cell Therapy
Industry Symposium
Pluripotency and Gamete Derived
Stem Cells
3:30–
5:00 pm
COFFEE BREAK
3:00–3:30 pm
Tissue Engineering I*
Symposium
ESOT – European Society for Organ
Transplantation
Stem Cell Transplantation and Immunomodulation
HALL 1
Embryonic Stem Cells
1:30–
3:00 pm
12:30–1:30 pm
LUNCH BREAK
NanoMicrostructures in Diagnostics,
Therapy and Therapeutic Monitoring:
Neuroperspectives
NanoMicrostructures in Diagnostics,
Therapy and Therapeutic Monitoring
Metabolism in Regenerative Medicine Biomaterials and Scaffolds for
Regeneration I
Law for hESC Research, Reimbursment, Ethics and Advanced Therapy
Products
11:00 am–
12:30 pm
10:30–11:00 am
COFFEE BREAK
Cartilage and Bone Engineering
Stem Cells: Emerging Developments
Stem Cells: Neuronal
HALL 5
HALL 4
Vascular Remodelling and
Angiogenesis*
HALL 1
8:30–
10:30 am
O C T O B E R 19, 2 0 0 7
HALL 3
Friday, October 19
Overview
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
23
Friday, October 19
Friday, October 19
HALL 1
HALL 4
1:30–3:00 pm
Embryonic Stem Cells
Chairs: C. Mason, S. Trkov
8:30–10:30 am
Vascular Remodelling and Angiogenesis
Chairs: A. Mol, M. Stekelenburg
M. Rao (Invitrogen Corporation) > keynote
ESC and embryotoxicity assays
> keynote
H. Mertsching
Engineering of vascularised tissues: State of the art
C. Lerch
Legal framework for human embryonic stem cell research in Europe and Germany and
its implications for regenerative medicine
J. Razavi
Regulation of galanin in human embryos and human embryonic stem cells
3:00–3:30 pm
Coffee break
3:30–5:00 pm
Pluripotency and Gamete Derived Stem Cells
Chairs: J. Hescheler, P. Bareiss
> keynote
W. Engel
Pluripotent stem cells from adult testis
T. Skutella
Spermatogonial stem cells from adult human testis and the generation of
pluripotency in vitro and in vivo
S. Danner
Derivation of oocyte-like cells from a clonal pancreatic stem cell line
C. Busch
Embryonic stem cells in human sacrococcygeal teratomas: Isolation and
characterization of an embryonic stem cell line
5:00–6:30 pm
Regulatory Affairs in Advanced Therapy Products
Chairs: H. Mertsching, M. Braun
> keynote
B. Sickmüller
Advanced therapies: State of discussions in Germany and the EU
> keynote
K. Cichutek
Regulatory aspects of advanced therapy medicinal products
> keynote
R. A. Lang
Macrophages regulate vascularization using the Wnt pathway: Implications for tissue
regeneration
C. Gentile
Bioengineering lumenized blood vessel-like tissue spheroids from adult human cells
J. Frese
Bioreactor development for capillary network formation in fibrin gel
FRIDAY
> keynote
J. Hescheler
Embryonic stem cells and regenerative medicine
T. Egana
Use of immortalized mesenchimal cells to induce in vivo angiogenesis during matrix
based dermal regeneration.
J. Trommer
Construction of small diameter vascular grafts based on decellularized matrices
seeded with aortic endothelial cells in a pulsatile flow bioreactor
10:30–11:00 am
Coffee break
11:00 am–12:30 pm
Metabolism in Regenerative Medicine
Chairs: D. Falkenhagen, P. Ahnert
> keynote
E. Holmes
The role of metabolic profiling in regenerative medicine
> keynote
M. Cross
Metabolic considerations in stem cell culture
E. Volkmer
3D-culture-associated central hypoxia accounts for quality gradients of engineered
tissues
L. Buravkova
Rat bone marrow-derived mesenchymal stromal progenitor cells under anoxia
12:30–1:30 pm
Lunch break
S. Sethe
Informed consent in tissue banking
U. Hoffmueller (Epiontis GmbH)
Quality control of autologous cell therapy based on DNA methylation markers
24
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
25
Friday, October 19
HALL 4
HALL 5
1:30–3:00 pm
Tissue Engineering I
Chairs: N. Jeffrey, A. L. Rosa
> keynote
D. W. Hutmacher
Comparison of mesencymal precursor cells from bone marrow and adipose tissue
from a tissue engineering perspective
> keynote
A. Mol
Heart valve tissue engineering: Current status and future prospects
M. Wöltje
Bone marrow or fat for soft tissue engineering: Comparison of preadipocytes and
mesenchymal stromal cells after adipogenic differentiation in vitro
A. Ovsianikov
3D hybrid polymeric scaffolds for tissue engineering
8:30–10:30 am
Cartilage and Bone Engineering
Chairs: N. zur Nieden, M. T. Raimondi
> keynote
F. Rustichelli
Advanced applications of X-ray synchrotron radiation in bone and muscle
regenerative medicine research
B. Kalpakcioglu
The interrelation of free radicals in osteoarthritis
S. M. Cool
Bone formation in a critical-size rat calvarial defect is enhanced by heparan sulfate
J. Weisser
Development of a biphasic matrix for osteochondral defects
W.-Y. Lin
The effects of chinese herbal medicine on chondrocytes for cartilage tissue
engineering
3:00–3:30 pm
Coffee break
3:30–5:00 pm
Stem Cells and Tumorigenesis
Symposium organised by the European Tissue Culture Society (ETCS)
Chair: A. M. Wobus
A. Trumpp
The role of Myc genes in stem cells during development, homeostasis and disease
F. Rosenbauer
Transcription factors and tumor stem cells
M. Wartenberg
ES-derived in vitro models for cancer research
5:00–6:30 pm
Placental Cells in Cell Therapy
Symposium organised by Pluristem Life Systems, Inc.
Chair: Z. Aberman
E. M. Horwitz
Novel insights into MSC therapy of bone disorders
A. Kaduri
The gap between the advanced basic research of stem cells and its industrial
therapeutic applications
A. Toren
Novel allogeneic cell therapy using PLX-I, a placental derived mesenchymal stromal
cell, grown in a 3D culture
26
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
FRIDAY
Friday, October 19
G. Schmidmaier
Mechanical stimulation affects osteoblast and osteoclast like cells
G. Gross
Strategies for regenerative mesenchymal stem cell therapies of skeletal disorders:
Pathways to tendon formation - Targeting of MSCs to cartilage tissues
10:30–11:00 am
Coffee break
11:00 am–12:30 pm
Biomaterials and Scaffolds for Regeneration I
Chairs: C. Semino, Y. Ibold
> keynote
M. Hofmann
Viability testing of bio-artificial tissue
> keynote
G. Orive
Therapeutic applications of cell encapsulation
D. W. Hutmacher
Evaluation of 2-year calvarial reconstruction with polycaprolactone and
polycaprolactone-based scaffolds in a rabbit model
R. Schade
Hydrostatic stimulation of chondrocytes on collagen I/III scaffolds
12:30–1:30 pm
Lunch break
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
27
Friday, October 19
Friday, October 19
HALL 5
R. Dressel
The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal
precursor cells depends on the recipients’ immune response
H. Schlitt
Current concepts of immunosuppression in allogeneic transplantation
HALL 3
L. Piemonte
Islet transplantation and stem cell cotransplantation
8:30–10:30 am
Stem Cells: Neuronal
Chairs: T. Skutella, M. Metzger
J. Sowden
Retinal repair by transplantation of photoreceptor precursors
R. Poulsom
Cell therapy for renal repair: Where are we now?
3:00–3:30 pm
Coffee break
3:30–5:00 pm
Stem Cells: Liver
Chairs: M. Alison, S. Salerno
> keynote
D. Kerr
Neurodegeneration and regeneration in the nervous system
> keynote
E. Sykova
Stem cells, biomaterials and nanotechnology for treatment of spinal cord injury
> keynote
F. Emmrich
Stem cell therapy in stroke
N. Weidner
Adult neural progenitor cells for spinal cord repair
> keynote
J. Gerlach
Bioreactor technology for liver progenitor cell-based therapy
> keynote
J. G. Hengstler
Liver regeneration after intoxication with CCl4: spacial-temporal mathematical
modelling in triple transgenic mice reveals the relevance of communication between
hepatocytes and sinusoidal lining cells
U. Gehling
Mobilization of unique populations of haematopoietic progenitor cells in response to
clinical situations associated with liver regeneration.
B. Christ
Differentiation of human adipose tissue derived mesenchymal stem cells to
hepatocyte-like cells in vitro and in vivo
5:00–6:30 pm
Immunologic Issues in Regenerative Medicine
Chairs: F. Emmrich, M. Schmitz
> keynote
A. Kurtz
Adoptive T-cell therapy to regenerate from chronic virus induced tissue-remodelling
S. Mitzner
Extracorporeal immune cell support for the treatment of bacterial sepsis
T. Ritter
Down-regulation of MHC class I protects mesenchymal stem cells against T-cell
mediated cytotoxicity in an inflammatory surrounding
28
J. Ladhoff
Endothelial derivatives of rat embryonic stem cells are less immunogenic in an
allogeneic setting
FRIDAY
1:30–3:00 pm
Stem Cell Transplantation and Immunomodulation
Symposium organised by the European Society for Organ Transplantation
(ESOT)
Chair: M. Alison
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
M. Skardelly
A longterm evaluation of the potency of a specific cellular transplantation procedure
as a therapeutic strategy after traumatic brain injury
10:30–11:00 am
Coffee break
11:00 am–12:30 pm
NanoMicrostructures in Diagnostics, Therapy and Therapeutical Monitoring
Symposium organised by the Deutsche Gesellschaft für Biomedizinische Technik
(DGBMT/VDE) and the Center for Biotechnology and Biomedicine (BBZ) Leipzig
Chairs: A. Robitzki, A. Rothermel
J. M. Cooper
Lab-on-a-chip technologies for diagnostics and cell analysis
A. Agarwal
Silicon nanowire sensors for label-free real-time diagnostics
J. Wegener
Nanoporous silicon surfaces as a novel tool to visualize the barrier characteristics
of 2D tissues
U. F. Keyser
Solid-state nanopores for understanding polymer transport in living cells
12:30–1:30 pm
Lunch break
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
29
HALL 3
1:30–3:00 pm
NanoMicrostructures in Diagnostics, Therapy and Therapeutical Monitoring:
Neuroperspectives
Symposium organised by the Deutsche Gesellschaft für Biomedizinische Technik
(DGBMT/VDE) and the Center for Biotechnology and Biomedicine (BBZ) Leipzig
Chairs: A. Robitzki, A. Rothermel
T. Stieglitz
Intelligent implants – A progress report on neuroprostheses
T. Arendt
Neuronal cells of Alzheimer brains are similar to tumour cells – progress in
therapeutic approaches
B. Schlosshauer
Tissue engineering of peripheral nerves
J. Boltze
Preclinical evaluation of autologous bone marrow cell therapy for stroke in a large
animal model
C. Emerson
Ethical issues in neuro-regenerative medicine: International perspectives
3:00–3:30 pm
WE MAKE YOUR CONFERENCE
A SUCCESS TO REMEMBER.
CONFERENCES. MEETINGS. EVENTS.
EVENT LAB.
Comprehensive Concept Development
Location Scouting
Reliable Budgeting
Personalised Participants Servicing
Complete Conference Materials
Class A Evening Programmes
Effective Sponsoring
Coffee break
3:30–5:00 pm
Innovative Methods and Drug Delivery Technologies
Chairs: A. Beck-Sickinger, J. Schmitz
> keynote
D. Anderson
Combinatorial development of biomaterials for tissue engineering and drug delivery
Y. Choo (Plasticell Ltd)
Stem cell differentiation using multiplexed combinatorial cell culture experiments
J. Park
BMP-2 gene delivery using a liposomal vector with bone grafts in peri-implant bone
defects on pig calvariae
P. Schwabe
The effect of non-viral delivery of BMP-2 plasmids with a copolymer protected gene
vector (coprog) incorporated in a poly(d,l-lactide) coating on fracture healing
C. Wiesner
Implementation of cell-based test systems for the characterization of potential
therapeutic drugs
5:00–6:30 pm
Imaging of Regeneration I
Chairs: H. Barthel, S. Vaga
> keynote
R. Graf
Imaging the dynamics of spreading depression in the ischemic penumbra
> keynote
M. Hájek
MR visualization of pancreatic islets transplantation by SPIO based contrast agents
T. Schmidt
Live imaging of mechanical stressed cells
N. Raschzok
Transplantation of primary human hepatocytes – Iron oxide labelling for cell detection via MRI
30
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
event lab.
Klein & Störmer GbR
Address
Telephone
Fax
eMail
Talstraße 30, D-04103 Leipzig
++49 (3 41) 401 19 36
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info@eventlab.org
www.eventlab.org
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
event lab.
31
Saturday, October 20
Imaging of Regeneration II
T. Gingeras (Affymetrix, Inc.)
Genome-wide maps of the human transcriptome reveal an interleaved organization
and novel short and long classes of RNAs
G. Verhaegh
PCA3 – A non-coding RNA involved in prostate carcinogenesis
Space Medicine Meets Regenerative
Medicine, continued
10:00–11:00 am
11:00 am–12:30 pm
Medical Applications of ncRNA, continued
Chair: P. Stadler
J. Vogel
Small noncoding RNAs of bacterial pathogens
SATURDAY
N. C. Meisner
mRNA Openers – Designed oligonucleotides for posttranscriptional upregulation of
target gene expression
12:30–1:00 pm
Lunch break
1:00–2:30 pm
Clinical Studies in Cell Therapy and Tissue Engineering
Chairs: T. Hoell, H. Fiegel
> keynote
J. Libera
EuroDisc Study – assessment of efficacy and safety of sequestrectomy plus
autologous disc chondrocytes – second interims analysis
* bioreactor presentation in session
Clinical Studies in Cell Therapy and
Tissue Engineering
Coffee break | Poster session | Poster award
C. Schimmelpfennig
Cellular therapy with cytokine induced killer cells (CIK cells) in patients with solid
tumors
O. Smikodub
Embryonic stem cells in duchenne muscular dystrophy
H. Gabr
Stem cell transplantation for liver failure: Impact on liver function and quality of life
M. Klentze
Proteomics, PET and early detection of prostate cancer
01:00–
02:30 pm
12:30–01:00 pm
11:00 am–
12:30 pm
8:30–10:00 am
Medical Applications of ncRNA
Chair: P. Stadler
Tissue Engineering II*
LUNCH BREAK
Materials, Surfaces and Implants*
Space Medicine Meets Regenerative
Medicine
Signal Transduction in Regeneration
ROOM 11
Medical Applications of ncRNA,
continued
C O F F E E B R E A K | P O S T E R S E S S I O N | P O S T E R AWA R D
Neurodegeneration and Repair
10:00–11:00 am
HALL 1
Symposium
Biomaterials and Scaffolds for
ICRS – International Cartilage Repair Regeneration II*
Society
How to Reconstruct Injured
Cartilage?
HALL 4
ROOM 11
Medical Applications of ncRNA
OCTOBER 20, 2007
32
8:30–
10:00 am
HALL 5
Saturday, October 20
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
33
Saturday, October 20
Saturday, October 20
HALL 4
1:00–2:30 pm
Tissue Engineering II
Chairs: T. Gilbert, B. Frerich
M. Brittberg
Chondrogeneic cells for cartilage repair: Basic and clinical aspects
W. Kafienah
Cartilage repair using stem cells: A pharmacological approach
L. B. Creemers
Aspects on cartilage regeneration and repair and future ideas
10:00–11:00 am
Coffee break | Poster session | Poster award
T. Drewa
Bladder acellular matrix seeded with hair follicle epithelial cells for urinary bladder
wall reconstruction – An animal study
M. Stiehler
Effect of 3-D dynamic culture on proliferation, distribution and osteogenic
differentiation of mesenchymal stem cells
B. Tschoeke
Tissue-engineered vascular graft based on a fibrin PLA scaffold
K.-H. Schuckert
Bone tissue engineering in humans using scaffolds, growth factors and PRP
11:00 am–12:30 pm
Materials, Surfaces and Implants
Chairs: B. Rauschenbach, V. Kordium
HALL 1
> keynote
A. Heilmann
Implant and cell culture characterization by Scanning Electron Microscopy (SEM) and
Focused Ion Beam Technology (FIB)
8:30–10:00 am
Biomaterials and Scaffolds for Regeneration II
Chair: I. Grunwald
I. Heschel
Tailoring three-dimensional collagen scaffolds with interconnected orientated pores
for potential applications in regenerative medicine
> keynote
C. Semino
Cellular-self organization could be promoted by material microenvironment
T. Habijan
The surface properties of powder metallurgically fabricated Nickel-Titanium Shape
Memory Alloys influence human multipotent mesenchymal stem cells‘ adhesion and
proliferation
K. Kratz
Biodegradation studies of aliphatic polyesters using the Langmuir monolayer
technique
J. C. Ionita
The use of biotechnological modified bone substitute materials in critical size defect
model in pigs
12:30–1:00 pm
34
Keynote lecture, tba
SATURDAY
8:30–10:00 am
How to reconstruct injured cartilage?
Symposium organised by the International Cartilage Repair Society (ICRS)
Chair: M. Brittberg
W. L. Neeley
A microfabricated poly(glycerol-sebacate) scaffold for retinal progenitor cell grafting
H. S. Koh
Modification of polymeric nanofibrous scaffolds with ECM bioactive molecules to
improve nerve regeneration
K. Luetzow
Loading of scaffolds with small molecules by integrated processes
O. Castano
Novel modified in-vivo casting for a Na-K doped calcium phosphate cement
10:00–11:00 am
Coffee break | Poster session | Poster award
Lunch break
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
35
Saturday, October 20
11:00 am–12:30 pm
Space Medicine meets Regenerative Medicine
J. Cornier
Opening
H.-C. Gunga
Space Medicine – General Overview
O. Ullrich
Cellular and molecular mechanisms of disturbed immune cells function in microgravity
D. Jones
Bioreactors for studying mammalian tissues in microgravity
H. van Beusekom
Cardiovascular regenerative research and microgravity
12:30–1:00 pm
Lunch break
1:00–2:30 pm
Space Medicine meets Regenerative Medicine
11:00 am–12:30 pm
Signal Transduction in Regeneration
Chairs: tba, B. Wildemann
> keynote
E. M. Tanaka
Limb regeneration and the multipotency of progenitor cells
S. Richardson
Differentiation of human mesenchymal stem cells to nucleus pulposus cells in type I
collagen gels: Implications for tissue engineering of the intervertebral disc
N. zur Nieden
Steering embryonic stem cell fate towards osteoblasts with downstream noncanonical wnt targets in vitro
K. Andreas
Key regulatory molecules of cartilage destruction in rheumatoid arthritis: An in vitro
study
H.-J. Stark
Long-term skin equivalents in vitro and integrity of their epidermal stem cell niche
12:30–1:00 pm
Lunch break
G. Reitz
Radiation risks in manned long term and interplanetary missions
1:00–2:30 pm
Imaging of Regeneration II
Chairs: C. Zilch, T. Schmidt
J. Kempf
ASTROHAB – A tool for extending human presence in space and understanding
environmental effects on biological processes and pathology
> keynote
P. Walczak
MR imaging and cell tracking in regenerative medicine
Panel Discussion
J. Cornier
Closing
>
M. Hofmann
PET for stem cell labeling
SATURDAY
HALL 1
keynote
> keynote
H. Barthel
New developments in PET imaging of stroke and stroke therapies
HALL 5
8:30–10:00 am
Neurodegeneration and Repair
Chairs: E. Sykova, U. J. Kang
> keynote
K.-S. Kim
Novel therapeutic approaches for Parkinson‘s disease
> keynote
P. A. Calabresi
Neuroprotective strategies in Multiple Sclerosis
M.-O. Baradez (ReNeuron Group pl)
Characterisation of REN005, a human neural stem cell derived from fetal striatum for
Huntington‘s disease therapy
A. Bozkurt
Neural tissue engineering using microstructured orientated collagen scaffolds
10:00–11:00 am
36
Coffee break | Poster session | Poster award
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
37
Poster exhibition
Scientific Session Tracking:
Color Code
ORANGE:
Metabolism and signalling
Posters
PP001 A. G. Abarrategi
Rhbmp-2/chitosan fi lm as titanium implant coating: in vitro characterization and in vivo bone
formation.
PP002 M. Ackermann
Long-term multilineage engraftment of human cells in nod/scid mice
YELLOW:
Immunology
PP003 M. Aliev
Infl uence of surgical stress on cd34+ cell circulation and cytokine production that modulate
biological activity of the hematopoietic stem cells (hsc).
DARK GREEN:
Materials, surfaces and implants
PP004 M. Arsalan
Human cardiac stem cells – there is a pool of autologous resident c-kit+ progenitors in the left
and right atrium
LIGHT GREEN:
Biomaterials and scaff olds
PP005 J. Azman
Reg i expression in regenerating skeletal muscle in rat
LIGHT BLUE:
Tissue engineering
PP006 H.-J. Bühring
Monoclonal antibodies 39d5 and w8b2 defi ne distinct msc subsets in human bone marrow
PP007 P. Büttner
Human SGBS cells are a valid model for human adipocyte diff erentiation
MEDIUM BLUE:
Tissue engineering – vascular remodelling and
angiogenesis
PP008 D. Back
Local application of Zoledronic acid from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats
DARK BLUE:
Cartilage and bone engineering
PP009 P. Baer
Conditioned medium from renal epithelial cells induces epithelial diff erentiation of human mesenchymal stem cells
LIGHT PURPLE:
Stem cells
VIOLET:
Neuronal stem cells
DARK PINK:
Imaging, cytometry
PINK:
Diagnostics, drug delivery, biomechanics,
quality control and nanotechnology
GREY:
Industry, regulatory issues and others
PP010 S. Bardelli
Adipose tissue as a source of stem cells for regenerative medicine
PP011
P. Bareiss
Characterisation of human epithelial stem and progenitor cells from intestinal mucosa
PP012 C. M. Bellini
Posterior interspinous dynamic stabilization of the lumbar spine: a biomechanical study
PP013 K. Bellmann
Intelligent Modifi cation of Regenerative Chemokines to Improve Pharmacokinetic Properties
PP014 M. M. Beloti
Use of a novel membrane of Poly(vinylidene-trifl uoroethylene)/Barium titanate for guided bone
regeneration
PP015 K. S. Blum
Eff ects of autotransplanted lymph node fragments on lymph vessel regeneration in minipigs
PP016 K. Boehnke
Epidermal Homeostasis and Extracellular Matrix Production in Long-Term Skin Equivalents
PP017 C. Boran
Study of recombinant protein tat-op1 in the osteogenic diff erentiation
PP018 D. Horna Tomas
Development of porous elastomers scaff old for tissue engineering applications
PP019 N. Marí-Buyé
Engineering a new functionalized hydrogel nanofi lm to study cellular behavior
PP020 O. Castano (oral)
Novel modifi ed in-vivo casting for a Na-K doped calcium phosphate cement.
PP021 H. C. Colley
Maintenance of mesenchymal stem cell phenotype by culturing on fi brin gels
PP022 R. Cowie
Eff ect of high frequency, low amplitude vibration on mesenchymal stem cells
PP023 M. Cox
The relationship between local mechanical environment and fi ber architecture and mechanical
properties of engineered cardiovascular tissues
38
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
39
Posters
Posters
PP024 A. Díaz-Cuenca
Chondrocyte cell-seeded collagen-ceramic composites for soft tissue grafts applications
PP047 B. Frerich
Quantitative evaluation of adipose tissue engineering in SCID mice
PP025 S. Danti
Poly(Propylene Fumarate)-based scaff olds for middle ear ossicle replacements: the eff ect of
pregenerated ECM on the osteoblastic diff erentiation of human MSCs.
PP048 S. Fricke
A humanised triple transgenic mouse model: Induction of acute GvHD and the eff ects of X-Rays
and chemotherapy on haematopoiesis
PP026 L. Dao
Fusion mediated regeneration of cells using adult stem cells
PP049 F. Galbusera
Cell population dynamics and oxygen transport in engineered tissue: a coupled Lattice Boltzmann – cellular automata model
PP027 R. di Liddo
3D model of human preadipocyte culture based on self-assembling peptide nanofi ber
PP028 R. Di Liddo
Enzymatic and biological activity of angiogenin and its tryptic peptides
PP029 A. G. Dias
Eff ect of plasma-rich in growth fcators (prgf) on behaviour of mg63 osteoblasts; preliminary
results
PP051 J. Garbade
There are global reverse remodelling eff ects of bone-marrow derived stem cells after right
heart application in non-ischemic heart failure
PP030 M.-T. Dieterlen
Generation of insulin-producing neurons from human neural stem cells
PP052 S. Geißler
The impact of donor age on functional behaviour and proteomic make up of mesenchymal stem
cells
PP031 S. Dietz
Stem cell based bone graft design using a perfusion and rotation system
PP053 M. C. Gioviale
Isolation and colture of β-like cells from porcine wirsung duct
PP032 L. Dreesmann
Angiogenic gelatin implant material
PP054 J. D. Glaeser
Modulaton of matrix metalloprotease activity in mesenchymal stem cells by variation of cycliccompressive loading
PP033 L. Dreesmann
Gelatin-based nerve conduit
PP034 K. Dunker
C-type lectins and the regulation of the immune system
PP055 C. Goepfert
Evaluation of in vitro-Cartilage Using Biochemical Parameters and Histological Grading Systems
PP035 L. Dyakonov
The skin cells culture is a perspective source of stem cells
PP056 F. Grandi
Skeletal muscle regeneration: evaluation of an experimental model by rt-pcr and cellular distribution.
PP036 L. Dyakonov
A comparative analysis of osteogenic diff erentiation of human bone marrow and adipose tissue
multipotent mesenchymal stromal cells at level of the gene-markers expression
PP057 C. Grandi
Structural and biological comparison of rnase-a, rnase-4 and angiogenin-1 as therapeutical proteins
PP037 C. Eder
The HET-CAM Test: A rapid, cheap and simple model for pre-assessment of biocompatibility in
tissue engineering research
PP058 O. Grinakovskaya
Permanent cultivation of human adipose tissue-derived mesenchymal stromal progenitor cells
under hypoxia
PP038 N. A. Elkhafi f
A comparison between ex vivo expansion of umbilical cord blood stem cells with and without
enrichment procedures
PP059 U. Großmann
Semi-automated radiosynthesis and in vitro testing of [18F]fl uoroetanidazole as a new surrogate marker for PET imaging of stem cell therapy in stroke Supported by the Translation
Centre for Regenerative Medicine of the University of Leipzig, Germany (project no. 1095MN)
PP039 A. Faikrua
The eff ect of chitosan’s sources on the physicochemical properties of collagen/chitosan matrix
PP040 E. Falkner
Health technology assessment for tissue engineering:quality control & risk/ benefi t/ cost
–analysis
PP041 T. Felka
Eff ects of Nitrosative Stress on the Metabolism of MSC
PP042 T. Fernández
A synthetic nanofi ber 3d-matrix allows mouse embryonic fi broblasts to diff erentiate into
mesodermal lineages
PP043 F. Feyerabend
In vitro corrosion and cytocompatibility of two magensium alloys
PP044 C. Fieber
Isolation and Characterisation of Human Melanocytes for Clinical Use
PP045 H. C. Fiegel
Passaging of different hepatic cell types isolated from fetal rat liver permits mass expansion
PP046 C. Heine
Characterization of the fi bre outgrowth in organotypic dopaminergic slice co-cultures
40
PP050 G. Gallego Ferrer
In vivo response of methacrylate-endcapped caprolactone scaff olds
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
PP060 J. Guerra
Xenogeneic infection risk and restriction of individual rights: An European approach (EU, German, Spanish and English Law)
PP061 A. Hartmann
Fibrin promotes matrix remodelling, active vessel and basal membrane formation in a 3D 3-cellular in vitro skin reconstruct
PP062 A. Höß
Nanoporous Aluminum Oxide for Cell Culture Applications
PP063 S. Höhle
Monitoring of ECM production in artifi cial cartilage constructs by MALDI TOF mass spectrometry and 13C NMR spectroscopy
PP064 S. Höhme
Liver regeneration after intoxication with ccl4: spatial-temporal mathematical modelling in
triple transgenic mice
PP065 M. Haberhauer
Tissue Engineering of Cartilage - Allogenous Plasma and Whole Blood Nanoscaff olds
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
41
Posters
Posters
PP066 E. M. Haddouti
Isolation and diff erentiation potential of human dental follicle stem cells
PP067 E. Hadjipanayi
Modelling Fluid Kinetics during Plastic Compression of Collagen Scaff olds
PP068 M. Hampel
In vitro three dimensional trachea model
PP069 S. Hau
Neuronal hypoxia in vitro: expression of cell adhesion molecules and eff ects on migration of
mononuclear cells
PP070 X. He
Roles of Sphingosine-1-phosphate and sphingosine kinase inhibitors in stem cell proliferation
and diff erentiation
PP071 A. Leal-Egana
Determination of the cell/aggregate growth profi le inside alginate capsules
PP072 A. Heilmann
Investigations with Scanning Electron Microscopy (SEM) and Focused Ion Beam (FIB) on cartilage tissues
PP073 S. Heinrich
Reduced corrosion rates and REDUCED metal ION release of stainless steel after surface
treatment with energetic ions
PP074 A. Hejcl
Hydrolytically degradable hydrogels in experimental spinal cord injury
PP075 S. Henning
Morphology, micromechanical mechanisms and mechanical properties of a resorbable nanocomposite material for bone regeneration
PP076 P. Hepp
Matrix-associated autologous chondrocyte transplantation (MACT) alone is not suitable for
deep chronical osteochondral defects – an in vivo study in sheep
PP077 C. Hohaus
The use of bone morphogenetic protein-2 for lumbar spinal fusion
PP078 H. Holland
Interphase- Fluorescence in situ Hybridization- technique for detecting human stem cells in
frozen xenogeneic tissue
PP079 I. Iandiev
Regeneration of retinal tissue – clearance of edema by triamcinolone ACETONIDE
PP080 Y. Ibold
Expansion of primary bone marrow-derived mesenchymal stem cells on microcarriers
PP081 L. Jahangiri
Mesothelial stem/progenitor cells of the peritoneumClonal characterization, Isolation and differentiation
PP082 P. Jendelova
Modifi ed iron oxide nanoparticles for in vivo cell imaging
PP083 S. Jopp
Bone tissue engineering using pcl-scaff old, rhbmp-2 and prp
PP084 J. Kajahn
Human pancreatic stem cells cultured on biodegradable meshes may serve as a myocardial
patch for regeneration of infarcted tissue
PP085 M. Keil
Gene transfection methods in cord blood derived cd34+ stem cells for in vivo imaging in nod/scid
mice
PP086 K. Kendziorra
Eff ect of progenitor cells on myocardial perfusion and glucose metabolism – investigated by
nuclear medicine techniques.
42
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
PP087 F. Kießling
The cd4 molecule as target of preliminary tests for induction of immunological tolerance in the
triple-trangenic mouse model (cd4/dr3)
PP088 J. Kim
Osteogenic diff erentiation of human mesenchymal stem cells in bone morphogenic protein-2
incorporated hyaluronic acid based hydrogels
PP089 A. Kinasiewicz
Modifi cation of hepatocytes culture by glycosaminoglycans for bioartifi cial liver.
PP090 A. Kinasiewicz
Alginate-collagen microbeads for cell culture and bioreactor.
PP091 F. Knöspel
Optimisation of chemically defi ned culture media for murine embryonic stem cells using factor
screening design analysis
PP092 J. Knauer
Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for
production of IL-23 required for IL-17 release by T cells
PP093 C. Knocke
From stem cell research to regenerative medicine - physical parameters can make the diff erence
PP094 L. Kock
Determination of the role of integrin α5β1 in cartilaginous ecm gene expression by chondrocytes embedded in agarose gel, in response to dynamic compression
PP095 V. Kordium
The use of non-biodegradable matrixes for the implanted cells fate study
PP096 J. Kosacka
Cholesterol and apolipoproteinD (ApoD) enhance neurite outgrowth and synapse formation in
dorsal root ganglia (DRG) cultures
PP097 A. K. Kretzschmar
Development of methods to unhide the multiple targets of miRNAs.
PP098 S. Krueger
Chondrocytes in vitro succeed in synthesising collagen type II containing extracellular matrix
only by adding human serum to a suitable three-dimensional cell culture system
PP099 R. Kurz
NanoMicroImplants for Controlled Drug Delivery
PP100 C. Lam
Evaluation of Long-term In Vitro Degradation of Polycaprolactone and Polycaprolactone-based
Scaff olds
PP101
C. Lantzsch
Stem cell based regeneration of the retina - retinospheres as model system
PP102 M. Lehmann
Comparison of diff erent 3D-cultivation systems to engineer human autologous in vitro cartilage-like tissue with focus on diff erentiation and viability
PP103 P. Lesny
Utilizing nonwoven nanofi ber materials as tissue replacements
PP104 J. Li
Angiotensin AT2 receptor mediates cardiac c-kit+ cell proliferation and supports survival of
cardiomyocyte
PP105 K Linke
Development of a vascularised liver cell module
PP106 Z.-M. Liu
Layer-by-layer assembly of glycosaminoglycansonto poly (l-lactide) for tissue engineering applications
PP107 A. Lochmann
rhBMP-2 Delivery From Scaff olds And In Situ-forming Gels
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
43
Posters
Posters
PP108 K. Lorenz
Vascularisation of dermal skin equivalents in vitro
PP130 D. Peroni
Stem molecular signature of adipose-derived mesenchymal stem cells
PP109 J. Lutz
Correlation between nitriding parameters of medical CoCr alloys and resulting hardness increase and reduction of wear rate
PP131
PP110
J. Müller
Npy receptors expression during retinogenesis
PP111
K. Müller-Zahm
Virus-like particles as gene transfer system for tissue engineering of cartilage
PP112
K. Ma
Modifi cation and characterization of blended nanofi ber substrates as skin grafts for the capture of bone-marrow derived hematopietic stem cells
PP113
K. Mahbubani
Preservation of cells for use in regenerative medicine
PP114
K. Mahbubani
Use of ph responsive polymers for a novel cancer treatment
PP115
M. Mahmoodinia
The role of wnt signaling in diff erentiation of cord blood unrestricted somatic stem cells into
dopaminergic neurons
PP116
D. Manova
Corrosion rateS of Mg alloys PRODUCED BY PVD PrOCESSES and resulting ion concentrations
in simulated body fl uid
PP117
M. Mather
In-process monitoring of foamed polymeric tissue scaff old fabrication
PP118
H. J. Meisel
EuroDISC Study – assessment of efficacy and safety of sequestrectomy plus autologous disc
chondrocytes – second interims analysis
PP119
M. Metzger
Isolation and biological potential of enteric nervous system precursors derived from human gut
PP120 J. Milosevic
Extracellular nucleotides govern human neural precursor cell proliferation and dopaminergic
diff erentiation
PP121
A. Mittag
A bead model for the realization of 3D Tissue Cytometry
PP122 C. Nesti
Neural stem cells cocultured with dental pulp stem cells preferentially diff erentiate into glial
cells
PP123 S. Neuss
Stem cells and polymers for tissue engineering applications
PP124 J. Ngoenkam
The eff ect of blending starch into chitosan/β-glycerophosphate on thermoresponsive property
PP125 M. Ngoenkam
Modifi cation of biomaterials with layer-by-layer technique
PP126 A. Niklas
Trial design of remyelination trials in multiple sclerosis: Reproducibility of visual evoked responses
PP127 H. Nitzsche
Diff erent Strategies for Production and Characterisation of Hydroxyapatite loaded CollagenChitosan-Scaff olds
PP128 A. Ovsianikov (oral)
3D hybrid polymeric scaff olds for tissue engineering
PP129 J. Park
Nano-scale microenvironment directs mesenchymal stem cell fate
44
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S. Peter
Large scale suspension culture of mesenchymal stem cells
PP132 A. E. Petschnik
Diff erentiation of human pancreatic adult stem cells into neuronal, glial and muscle cells
PP133 D. Pollet
Image analysis approach for the application of embryonic stem cell-derived myocards in pharmacological research
PP134 I. Hanisch
Acceleration of bone regeneration through application of erythropoetin
PP135 L. Quintana
Self assembly and reprogramming of dermal fi broblasts in a 3d nanofi ber SCAFFOLD
PP136 M. T. Raimondi
The eff ect of low regimens of interstitial perfusion on the development of engineered cartilage
PP137 D. M. Reich
Neuronal hypoxia: protective effects of mononuclear cell fractions after direct and indirect application
PP138 C. Rentsch
The osteogenic potential of embroidered polycaprolactone-co-lactide scaff olds coated with
collagen i and chondroitin sulfate, seeded with human mesenchymal stem cells and implanted in
a critical size femoral defect in rats
PP139 R. Revoltella
Selective growth and expansion of human corneal epithelial basal stem cells in a three-dimensional-organ culture
PP140 R. Revoltella
Three-dimensional organotypic cultures to investigate human conjunctival epithelial precursor
cells and their progeny within their natural microenvironment
PP141
R. Revoltella
Selective Growth of Epithelial Basal Cells From Human Prostate in aThree-Dimensional Organ
Culture
PP142 S. Richardson
Intervertebral disc regeneration using chitosan-glycerophosphate hydorogels and diff erentiated human mesenchyal stem cells
PP143 M. Keller
Three Dimensional Culture Model for Polarized Hepatocytes in a Bioreactor
PP144 A. Leal-Egana
Profi le of gfp release derived from transformed fetal hepatocytes in alginate microcapsules.
PP145 A. Luiz Rosa
Tissue engineering: in vivo bone response to the biomaterial obtained by seeding stem cells into
porous CaP/PLGA scaff old
PP146 M. Rostovskaya
Clonal characterization of bone marrow mesenchymal stem cells using conditionally immortalized lines from tetracycline regulated sv40 large t-antigen transgenic mice.
PP147 M. Rubbens
Intermittent straining accelerates the development of tissue properties in engineered cardiovascular tissues
PP148 T. Rupf
Dynamic seeding of scaff olds improves fabrication of dermal layers in skin bioreactors
PP149 S. Salerno
Reconstruction of Human Liver Functions in Novel Polyetheretherketone-Polyurethane (PEEKWC-PU) Membrane Bioreactor
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
45
Posters
Posters
PP150 T. Sawada
Erythropoietin and its derivative stimulate angiogenesis by bone marrow cells
PP171
PP151
PP172 O. Smikodub
Embryonic Stem Cell Transplantation in Multiple Sclerosis
R. Schäfer
The Use of Clinically Approved Small Particles of Iron Oxide (SPIO) for Labeling of clonal rat
Mesenchymal Stem Cells Aggravates Clinical Symptoms in Experimental Autoimmune Encephalomyelits (EAE)
PP173 O. Smikodub
Embryonic Stem Cells in Rheumatoid Arthritis
PP152 G. Schaarschmidt
Overexpression of functional cation channels in neural stem cells
PP174 O Smikodub
Embryonic Stem Cells in Metabolic Syndrome
PP153 N. Scherf
An automatic analysis of cartilage regeneration in an model of human/murine scid arthritis
PP175 O. Smikodub
Embryonic Stem Cells in Insulin Resistance Decrease in Patients with Impaired Glucose Tolerance
PP154 S. Schewtschik
New culturing strategies to optimise functional neural development from midbrain derived
neural precursors
PP176 C. Stamm
Mechanical stress facilitates coupling of skeletal myoblasts with cardiomyocytes
PP155 E. Schilling
Determination of cell-biological parameters of non-activated and activated (LPS) monocytes in
response to diff erent synthetic soft materials under the infl uence of shear stress
PP177
PP156 U. R. Schmidt
Intravenous administration of Human Umbilical Cord Blood Cells after stroke in rats: investigation of the therapeutic time window regarding functional recovery
PP178 C. Stamm
Cryopreserved human bone marrow progenitor cells as a potential cell source for cardiovascular tissue engineering
PP157 T. Schmidt (oral)
Life imaging of mechanical stressed cells
PP179 M. Stekelenburg
From strong human tissue-engineered vascular grafts to an in-vivo porcine model
PP158 M. Schmitz
Mesenchymal stem cells effi ciently impair the immunostimulatory capacity of native human
dendritic cells
PP180 H. Stephan
Development of a high content screening system for investigation of the infl uence of the extracellular matrix on adhesion and proliferation of human neural progenitor cells
PP159 K. Schroeck
Characterization of a new material for human mesenchymal stem cell-based bone tissue engineering
PP181
PP160 R. Schulz
Development of a bioreactor system for the regeneration of 3D cartilage-grafts
PP161
G. Schulze-Tanzil
Cell surface receptor expression for adenoviral cell entry is modulated by culture conditions in
human articular chondrocytes
C. Stamm
Autologous bone marrow mononuclear cell implantation in lvad patients with end-stage nonischemic cardiomyopathy
J. Stevens-Smith
The eff ect of oxidative stress on bone formation in vivo
PP182 M. Stiehler (oral)
Eff ect of 3-D dynamic culture on proliferation, distribution and osteogenic diff erentiation of
mesenchymal stem cells
PP183 A. Stolzing
Mesenchymal stem cells and bone fracture risk in diabetes mellitus
PP162 S. Schwan
Mechanical testing of a protein based scaff old made by three phase production process
PP184 B. Stratmann
Autologous tissue repair cells in the treatment of limb ischemia induced chronic ulcers of diabetic foot patients
PP163 P. Schweizer
Adhesion, proliferation and diff erentiation of primary human keratinocytes on chemically functionalized nano- and microstructured surfaces
PP185 C.-Y. Su
Concilletin-the advent of a new antiinfl ammatory agent-
PP164 A. Scutt
Eff ect of cannabinoids on mesenchymal tissues
PP165 N. Scutt
The eff ect of in vivo ageing on rat tendon cells
PP186 C.-H. Su
Application of chitin containing cell wall of fungi for acute and chronic wound therapy
PP187 G. Tanasie
In vitro growth of human mesenchymal stem cells seeded on 3d polymeric matrices
PP166 K. Seifert
Small molecules as agonists of hedgehog signaling and their use for wound healing
PP188 A. R. Thomsen
The role of oxygen tension in rediff erentiation of human articular chondrocytes - a fl ow cytometric study
PP167 D. Seitz
Glutaraldehyde-crosslinked chitosan scaff olds with adjusted mechanical properties and porosity as cartilage scaff olds for dynamic compression cultivation
PP189 S. Trepke
Retroviral vector design for stable cell transduction
PP168 D. Seitz
A biocompatible sensor-array instrument with rapid coupling mechanism for online-measurement of physiological data in cell cultures
PP169 J. Shved
Polylactide fi lms for substitutive cell therapy of skin
PP170 M. Skardelly
In vivo tracking of xfp expressing murine fetal neural stem cells by two photon laser scanning
microscopy (2plm) after tbi
46
O. Smikodub
Experience of Application of Embryonic Stem Cells (ESC) in Amyotrophic Lateral Sclerosis
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
PP190 S. Trettner
Osteogenesis in primate embryonic stem cells
PP191
S. Trkov
Characterization of adherent clonogenic cells isolated from human umbilical vein
PP192 L. Trombi
Human autologous plasma derived clot as a biological scaff old for mesenchymal stem cells in
treatment of orthopaedic healing
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
47
Posters
Posters
PP193 W.-B. Tsai
Mechanical compression modulates the biochemical behavior of chondrocytes seeded in elastic
chitosan/gelatin scaff olds
PP194 E. Twerdowski
Combined ultrasonic and confocal laser scanning microscopy of biological objects
PP195 F. Ugarte
Analysis of the role of Notch signaling in the cell fate determination of bone marrow human
mesenchymal stem cells (hMSC).
PP196 S. Vaga
Delayed gadolinium-enhanced magnetic resonance imaging (dgemric) for the quantifi cation of
glycosaminoglycans depletion and regeneration in human intervertebral discs
PP197 P. Verma
„Liver like“ three dimensional spheroids of human hepatocyte cell line on agar gelatin scaff olds
for preliminary drugs and chemical toxicity
PP213 K. Wiegandt
Optimization of growth factor supplements for the generation of cartilage-carrier-constructs
PP214 B. Wildemann
Growth factor quantifi cation in diff erent bone graft materials
PP215 E. Wunder
Distribution patterns of cd34 antigen on cord blood progenitors
PP216 N. Yudintseva
Fibrin equivalent can be used for treatment diff erent etiology skin wounds.
PP217 V. Zaporozhan
Regenerative medicine: state in ukraine
PP218 C. Zechel
Infl uence of growth factor cocktails and growth matrices on proliferation and diff erentiation of
stem cells from the adult mammalian brain
PP198 V. Verma
Human hair proteins: potential scaff old materials for tissue engineering
PP219 A. Zhirkov
The cellular therapy impact on bone tissue regeneration and psychological status of patients
with mechanical injury
PP199 J. Viyoch
Keratinocyte growth factor receptor and keratin 4-14 expression in human keratinocyte
growth on blending collagen/crab chitosan scaff old
PP220 M. Zscharnack
Increased chondrogenic diff erentiation of bone marrow derived MSCs after expansion in low
oxygen tension.
PP200 J. von der Ruhr
Improved vascular regeneration and impeding of re-stenosis by Shikonin based stent coatings
PP221 N. zur Nieden
Enrichment of Mesenchymal Progenitors from Embryonic Stem Cells
PP201 M. Vorobeychik
Induction of pancreatic beta-cell phenotype in hepatic progenitor cells (hpc) isolated from adult
diabetic mice.
PP222 N. zur Nieden (oral)
Steering embryonic stem cell fate towards osteoblasts with downstream non-canonical wnt
targets in vitro
PP202 B. Voss
Homing and Diff erentiation of transplanted Bone Marrow Cells in Livers of Murine Schistosomiasis
PP203 M. Wöltje (oral)
Bone marrow or fat for soft tissue engineering: Comparison of preadipocytes and mesenchymal stromal cells after adipogenic diff erentiation in vitro.
PP204 D.-C. Wagner
In vivo infarct volumetric analysis upon experimental stroke in rat using a 1.5T clinic MR scanner – an investigation of lesion development comparing local versus systemic stem cell administration
PP205 B. H. Walpoth
Feasibility assessment of a new device for intraoperative laser and cell therapy in the pig heart
PP206 E. Wandel
Interaction of leucocyte antigen cd97 and the activation associated endothelial receptor thy-1
(cd90)
Late Submissions
PP223 S. Arain
Online monitoring of DO and pH in multiwell plates - A novel approach to defi ned conditions for
cell cultivation
PP224 T. Douglas
Hydrostatic pressure (HP) stimulation of human mesenchymal stem cells (hMSCs) seeded on
collagen-coated titanium substrates and polycaprolactone (PCL) scaff olds
PP225 J. F. Douglas
Renal Replacement Therapy (RRT) cannot solve the problems of Chronic Kidney Disease (CKD).
Research into CKD prevention, nephron preservation and renal tissue regeneration urgently
requires funding
PP207 C.-H. Wang
Preparation of injectable collagen matrix for adipose tissue engineering
PP226 A. Efi menko
Angiogenic properties of adipose-bone marrow derived mesenchymal stromal cells under hypoxia and infl ammation in vitro
PP208 K. Warstat
Attachment of MSC to ECM proteins does not infl uence their TGF-ß1 responses.
PP227 N. W. Guldner
Detoxifi cation, titanization and endothelialization of glutaraldehyde- fi xed collagen scaff olds
PP209 A. Wegehaupt
Library screens for the identifi cation of therapeutic targets
PP228 N. Nonoguchi
Efficient induction of neuronal progenitors from bone marrow stromal cells
PP210 F. Wegner
Analyses of primary human fetal cells and derived mesencephalic neural precursors in vitro
PP229 K. Ullmann
Identifi cation, validation and characterization of novel prostate cancer specifi c microRNAs
PP211
PP230 R. Slavkovsky
Hyaluronan is an active molecule in the angiogenesis. In vitro study of the eff ect of hyaluronan
on human dermal microvascular endothelial cells (HDMVEC)
U. Wehrmeister
Comprehensive in vitro model for the engineering of microvasculature - evaluation of morphological and functional data
PP212 T. Weigel
Shape-memory polymer nanocomposites responsive to alternating magnetic fi elds
48
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
49
Evening functions
Special Dinner Lecture
Wednesday, 17 October 2007, 7:30 pm
Old Stock Exchange
The Old Stock Exchange situated close to the Market Square behind the Old
City Hall was built in 1687 and is the only baroque building in Leipzig.
Here merchants once concluded contracts when fairs were underway. The
spending hall on the first floor is now used for small functions. We are pleased
to invite you here for the Special Dinner Lecture.
Oliver Brüstle from the Institute of Reconstructive Neurobiology at the University of Bonn will speak about “Human ES Cell-Derived Neural Stem Cells.”
Get together
Thursday, 18 October 2007, 5:30 pm
Following the scientific program, we would like to invite you to a pleasant and
informal evening in the exhibition area at the Congress Center. The Get-together is included in the registration fee for all participants, exhibitors and
sponsors.
Social Evening
Friday, 19 October 2007, 8:00 pm
Modern Research Meets Colourful History
Leipzig certainly does have a colourful history. During the evening function
you will have the opportunity to find out more about on of the city´s historical
highlights – the Moritzbastei.
The Moritzbastei is the only remaining part of the ancient city fortifications. In
the 70’s students began to work on the Moritzbastei, freeing it of the debris
it was filled with and turning it into a students’ club.
The evening will include some tasty delicacies reflecting regional cuisine as
well as entertainment.
Price per person:
60.00 € includig 19% VAT
(including food and beverages)
50
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
51
Sponsors & Exhibitors
GOLD SPONSOR
Pluristem Therapeutics Inc.
Haifa
SILV ER SPONSOR
EXHIBIT ORS
38
Labotect Labor-Technik Göttingen GmbH
Göttingen
15
Lehmanns Specialised Bookstore
Leipzig
44
Leica Mikrosysteme Vertrieb GmbH
Wetzlar
10
Matricel GmbH
Herzogenrath
24
Metabion International AG
Martinsried
39
Boo th
Millipore GmbH
Schwalbach
54
Boo th
Thermo Electron LED GmbH
Langenselbold
42
NeuroProgen GmbH Leipzig
Leipzig
—
EXHIBIT ORS
52
Boo th
Boo th
AbD Serotec
Oxford
45
Miltenyi Biotec GmbH
Bergisch-Gladbach
51
Advalytix AG
Munich
35
Multi Channel Systems MCS GmbH
Reutlingen
53
Amaxa GmbH
Cologne
12
Nikon GmbH
Düsseldorf
14
Zürich
46
Applied Biosystems Applera Deutschland GmbH
Darmstadt
34
Nisco Engineering AG
Beckman Coulter GmbH
Krefeld
47
Olympus Deutschland GmbH - Mikroskopie
Hamburg
36
Becton Dickinson GmbH
Heidelberg
52
ORF Genetics
Reykjavik
30
BioE Inc.
St. Paul, MN
4
PAA Laboratories GmbH
Cölbe
5
Bionas GmbH
Rostock
49
PeproTech EC Ltd.
London
29
Regensburg
28
BIOSAFE SA
Eysins
9
PreSens Precision Sensing GmbH
biosaxony
Dresden
32
Progenitor Cell Therapy LLC
Hackensack, NJ
6
Bioscora GmbH
Leipzig
19
Projektträger Jülich - Forschungszentrum Jülich GmbH
Berlin
20
BioSpherix, Ltd.
Redfield, NY
31a
QIAGEN GmbH
Hilden
18
Carl Zeiss MicroImaging GmbH
Jena
50
R&D Systems Europe Ltd.
Abingdon
7
Vancouver, BC
27
Charles River Laboratories GmbH
Sulzfeld
23
StemCell Technologies, Inc.
Chip-Man Technologies Ltd.
Tampere
31
Translational Centre for Regenerative Medicine
Leipzig
41
Cluster Life Sciences Mitteldeutschland
Halle/Saale
40
TÜV Süd Product Service GmbH
Munich
3
Cytonet GmbH & Co. KG
Weinheim
17
VITA 34 AG
Leipzig
22
DASGIP AG
Jülich
33
Wilhelm-Ostwald-Gymnasium
Leipzig
11
Oberkrämer
25
Frankfurt
26
Eppendorf Biochip Systems GmbH
Hamburg
16
Zellwerk GmbH
Eufets AG
Idar-Oberstein
21
Zinsser Analytic GmbH
Ewald Innovationstechnik GmbH
Bad Nenndorf
48
Fraunhofer Life Sciences Alliance (VLS)
Hanover
13
SPONSORS
Future Medicine Ltd.
London
8
Aastrom Biosciences, Inc.
Ann Arbor, MI
Cambridge
Asbach
German Society for Regenerative Medicine e.V.
Frankfurt
2
Antitope Ltd.
Gesim mbH
Radeberg
1
Dunn Labortechnik GmbH
HiSS Diagnostics GmbH
Freiburg
43
Eccocell Biotechnologie GmbH
Graz
Munich
Dresden
Invitrogen Corporation
Carlsbad, CA
28a
Maiwald Patentanwalts GmbH
Labor Dr. Reising-Ackermann und Partner
Leipzig
37
Saxony State Ministry for Economic Aff airs and Labor
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
53
Catering Outside
Exhibition plan
Level +1
Lecture Hall 3
Lecture Hall 5
Exibition Booths no. 33–54
Terrace Catering
Smoking Area
Exibition Booths no. 1–32
Elevator
Exhibition plan
Level 0
Elevator
Catering
Lecture Hall 4
Catering
Atrium
Internet
Foyer West
Elevator
Atrium
Lecture Hall 1
Preview Area
Elevator
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3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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General information
Congress Coordinator
Professor Frank Emmrich
Fraunhofer Institute for Cell Therapy and Immunology
Deutscher Platz 5e
04105 Leipzig
Public Transport
You are authorized to use public transport (within Leipzig and including airport) with
your name tag for the duration of the meeting, 17–20 October 2007.
Registration Fee
Congress Dates
Wednesday
October 17, 2007
04:00 pm–07:00 pm
Thursday
October 18, 2007
07:30 am–08:00 pm
Friday
October 19, 2007
07:30 am–08:00 pm
Saturday
October 20, 2007
08:00 am–03:00 pm
Congress Venue
Congress Center Leipzig
Messe-Allee 1
D-04105 Leipzig
www.ccl-leipzig.de
Language
The official language of the congress is English.
Participation/ Badges
Official congress name tags will be required for admission to all congress functions, scientific sessions and exhibition areas. Individuals who lose their name tags will have to
pay a fee of 15 € to obtain a replacement tag.
Exhibition Information
The exhibition of the 3rd World Congress on Regenerative Medicine, featuring commercial displays of pharmaceutical and product companies, medical publishers will be
located in the foyer areas of the Congress Center, floor 0 and +1.
The exhibition will be open on the 18 th of October, 9:00 am–8:00 pm and on the 19 th of
October, 9:00 am–6:00 pm. The Get-together on 18 th of October will take place in the
exhibition area.
Registration fees
On-Site
Day Ticket
18 th
19th
20th
—
—
—
Fraunhofer Life Science Symposium
175.00 €
Speaker (1)
275.00 €
175.00 €
Member (2)
400.00 €
250.00 €
Non-member
425.00 €
285.00 €
Student/Resident (3)
150.00 €
80.00 €
Accompanying person (4)
160.00 €
80.00 €
(1)
This registration fee is valid only for delegates who will give an oral presentation as well as for staff
members of the University of Leipzig.
(2) This registration fee is valid for members of the following organisations: ASAIO, DGBMT, DGfI, ESAO, ESB,
ESOT, ETCS, GBZ, GRM, ICRS, ISAC, REGENERATE, TERMIS.
(3) Please provide proof of your status with the registration.
(4) Please note that accompanying persons are not permitted to participate in the scientific program.
The registration fee includes:
> Participation in the scientific program
> Name tag and delegate bags incl. abstracts
> Use of public transportation in Leipzig
> Food and beverages during the conference
Poster Presentation
The poster exhibition will be situated in the Conference Center, Floor +1. Presentations
of posters will be on Thursday, October 18, 2007 during the Get-together (5:30–
7:30 pm) and on Saturday, October 20, 2007 during the coffee break (10:00–11:00 am).
The Poster award ceremony will be on Saturday as well at 12:30 pm.
> Get-together
Materials for putting up the posters will be provided.
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3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
57
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How to get to the Congress Center Leipzig
from the airport
The Airport Express runs every
30 minutes between the airport
and Leipzig main station, stopping
at “Leipzig-Neue Messe” station
on the way. The ride to the Exhibition station takes 8 minutes.
2
by train
You can get to Leipzig Exhibition Centre from the city centre
taking tram no. 16. From Leipzig
main station to “Messegelände”
(terminus) – the ride takes approx.
15 minutes. Trams run every 10
minutes and take you almost right
up to the main entrance of the
congress center.
3
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by car
Please follow the signposts in and
around Leipzig. Leipzig Exhibition
Centre (“Messegelände”) is very
well signposted. The parking guidance system is helpful for finding
parking spaces and will guide you
quickly and safely to any free
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EN
3 rd W O R L D C O N G R E S S O N R E G E N E R A T I V E M E D I C I N E
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Seaside Park Hotel****
2
Hotel im Sachsenpark***
3
Vivaldi Hotel***
4
ibis Leipzig Zentrum**
5
Renaissance Hotel****
6
Moritzbastei
7
Old Stock Exchange
8
Main station
OCTOBER 18–20, 2007 | CONGRESS CENTER LEIPZIG/GERMANY
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