Personal Statement

Bilder, David
Principal Investigator/Program Director (Last, first, middle):
BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
David Bilder
Professor of Cell and Developmental Biology
EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
MENTOR
Harvard Medical School
Stanford Medical School
Harvard College
Postdoc
Ph.D.
B.A.
2001
1997
1990
Genetics
Developmental Biology
Biology
Norbert Perrimon
Matt Scott
Walter Gilbert
Personal Statement
Research in my laboratory focuses on the biology of epithelia, the fundamental cell type of animal
species. Using forward genetic screens in Drosophila as entry points, we study the molecules and mechanisms
that govern epithelial polarity, cell shape, and tissue morphogenesis. We also seek to understand how
epithelial organization promotes the proper control of organ growth, a surprising connection uncovered by our
analysis of fly tumor suppressor genes that represents a general principle relevant to human cancer.
Professional Experience:
2012-date
Professor, Dept. of Molecular and Cellular Biology
University of California-Berkeley
2007-2012
Associate Professor, Dept. of Molecular and Cellular Biology
University of California-Berkeley
2002-2007
Assistant Professor, Dept. of Molecular and Cellular Biology
University of California-Berkeley
1997-2001
Postdoctoral fellow, laboratory of Norbert Perrimon
Dept. of Genetics/HHMI, Harvard Medical School
Topic: Genetic analysis of epithelial cell architecture
1991-1997
Graduate student, laboratory of Matt Scott
Dept. of Developmental Biology/HHMI, Stanford Medical School
Thesis: Patterning the Drosophila digestive tract: Hox genes and signals
1988-1990
Undergraduate honors student, laboratory of Walter Gilbert
Dept. of Cellular and Developmental Biology, Harvard University
Thesis: Role of cell surface proteins in mouse neural development
Awards and Honors:
2015
President, National Drosophila Board of Directors
2010
H. W. Mossman Developmental Biologist Award
2002
Searle Scholars Award
2001
Burroughs-Wellcome Career Award in the Biological Sciences
2000-2001
Leukemia and Lymphoma Society Special Fellowship
1997-2000
American Cancer Society, Postdoctoral Fellowship
1992-1995
National Science Foundation Graduate Research Fellowship
1990-1991
Sheldon Traveling Fellowship (Papua New Guinea and Zaire)
Recent Service Highlights
Biographical Sketch Format Page
Principal Investigator/Program Director (Last, first, middle):
Bilder, David
Member, DEV2 NIH Study Section (2014-2020)
Founder and Chair, Drosophila Image Award Committee (2003-present)
Editorial board, Development (2004-present)
Board of Overseers, St. Kitts Biomedical Research Foundation (2004-present)
Selected Publications (of 48 total):
Primary Research:
Figueroa-Clarevega A and D Bilder (2015). Malignant Drosophila tumors interrupt insulin signaling to induce
cachexia-like wasting. Dev Cell, 33.
Bunker BD, Nellimoottil TT, Boileau R, Classen AK, and D Bilder (2015). The Transcriptional Response to
Tumorigenic Polarity Loss in Drosophila. eLife, Feb 26;4. doi: 10.7554/eLife.03189.
De Vreede G., Schoenfeld JD, Windler SL, Morrison HA, Lu H, and D Bilder (2014). Scribble regulates
endocytic, retromer-dependent recycling during epithelial polarization. Development, 141: 2796-802.
Skwarek LC, Windler SL, De Vreede G, Rogers GC and D Bilder (2014). The E3 ubiquitin ligase component
Slmb restricts atypical PKC activity to polarize epithelia. Development, 141:2978-83.
O’Brien LE, Soliman SS, Li X and D Bilder (2011). Altered Modes of Stem Cell Division Drive Adaptive
Intestinal Growth. Cell, 147: 603-614
Haigo SL and D Bilder (2011). Global Tissue Revolutions in a Morphogenetic Movement Controlling
Elongation. Science, 331(6020):1071-4
Windler S. and D Bilder (2010). Endocytic internalization routes required for Delta/Notch signaling. Current
Biology, 20: 538-43.
Classen AK, Bunker BD, Harvey KF, Vaccari T, and D Bilder (2009), A tumor suppressor activity of Drosophila
Polycomb genes mediated by JAK-STAT signaling. Nature Genetics, 41:1150-5
Vaccari T, Lu H, Kanwar R, Fortini, M and D Bilder (2008). Endosomal Entry Regulates Notch Receptor
Activation in Drosophila. Journal of Cell Biology, 180: 755-62.
Lu H and D Bilder (2005). Endocytic control of epithelial polarity and proliferation in Drosophila. Nature Cell
Biology, 7 (12): 1132-9.
Vaccari T and D Bilder (2005). The Drosophila tumor suppressor vps25 prevents non-autonomous
overproliferation by regulating Notch trafficking. Developmental Cell, 9 (5): 687-98.
Bilder D, Schober M and N Perrimon (2003). Integrated activity of PDZ protein complexes mediates the
maturation of epithelial polarity. Nature Cell Biology, 5: 53-58
Bilder D, Li M and N Perrimon (2000). Cooperative regulation of cell polarity and growth by Drosophila tumor
suppressors. Science 289 (5476): 113-6.
Bilder D and N Perrimon (2000). Localization of apical epithelial determinants by the basolateral PDZ protein
Scribble. Nature 403 (6770): 676-80
Reviews:
O’Brien LE and D Bilder (2013). Beyond the Niche: Tissue-level Coordination of Stem Cell Dynamics. Ann
Rev Cell Dev Biol, 29: 107-36.
Bilder D and SL Haigo (2012). Expanding the Morphogenetic Repertoire: Perspectives from the Drosophila
Egg. Developmental Cell 22: 12-23.
Shivas JM, Morrison HA, Bilder D and Skop, AR (2010). Polarity and endocytosis: Reciprocal regulation.
Trends in Cell Biology, 20: 323-331.
Biographical Sketch Format Page +
Principal Investigator/Program Director (Last, first, middle):
Bilder, David
Fortini ME and D Bilder (2009). Endocytic regulation of Notch signaling. Curr Opin Genet Dev. 19:323-8.
Hariharan I and D Bilder (2006). Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila.
Annual Reviews of Genetics, 2006;40:335-61.
D Bilder (2004). Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor
suppressors. Genes and Development 18: 1909-1925.
Biographical Sketch Format Page +