Beeinflussung des Proliferationsverhaltens hormonaktiver Mamma
Transcription
Beeinflussung des Proliferationsverhaltens hormonaktiver Mamma
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`F 1&&`F $ T = -A3$ = A) )$ ! = C . O =. , A6 3 $ . 3 - =3 . " 3 $ # 3 O2 $ != A+872 , +&2: +&20 F . A6 +&2; +&2+& F $= A" O2 )2 $ ,3 . # O2 B $ # = AO2 .36/ A6 3$ ! = )2 $ " " & # ) 3C UD = * -2D=-V. =6 * * G=**I. ". , %&+&0 $/$$. 6 ,6B*) .a.=." A.=@++&Bb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` !""2" 66L %$I %& ` =6 L 66 G# C C C I 4$I %&` C 6,+(%& :$I ,A2 1$I T 3 C 3 =6 C 6 $ +& ` ;$I 3 6 1A1# 8$I -C 6 0$I ,3C F cG C IA+&A+&:C F =$4(# -C $+%(! -2C & & ' 22( ! = - @ , C $ D 3 # 42Q:.12 2%2 2%.12 6 2 G"==I ! C 6 $ "==2# 2 . 3 L " " $!6 3 B/2$!C 3 %.1 `F 1&& `F . 3 C ! "==2# "==2 # 2 6 $ ! B/ L 6 6 "==2#$/ 6 C $ !(GI +$I 1&$&&&C F@ G+&&` IYA6 GA.6$F$ 2 = A. .JD+KI.3';2@ 2) %:48H*F1K *J% %$I +&` F@ "==2 23: 4$I +&&` F@ / LO :$I 6 3 G6 I B/2 18& *)( ! - = L "==2= S S - C 3 $ ! -2) $" !O 6 = 12 2%P2A G-I$ O A . 3 C A !O $ - !O 6 C . 6L6G2-2)J!I= $>T )A 3 / # L$ ! # 7 B/2 6 3$ !(GI +$I 1&$&&&C F@ G+&&` I 3 ';2@ 2) %:48H*F1K*J% C 3 %$I +` F@ A )$FO$2 G= A. . JD +KI 7%:G48H*F1K*J%I " " 4$I +&` F@ -2 2 3 - G48H*F1K*J%I :$I C #A %&& ` #A2!E 4& +12%1H* 1$I #A L +&&` F@ 2-2)J! GL6I'& +12%1H* ;$I L6 @ %&&` F@ @2 8$I @ L +&& ` F@ /2 G#I+1 0$I 66# %1` F@ +"D%/J: '$I "6 B/2G:1& I 7&(>!6 C.@ AL C . B!D2CA$ ! S - " B2! GB!DI C . 3 L B!D C C " $ ! DL 66 " L C $ # C . " B!D $ C = 3 7 > 3. , C $!B!D .3 $ +4 . =6 3 B ) O!Y O!DFDY$ 3 / 3 DFDY O!DFDY = O= G%2Q:26 R242Q:26 R212 6 I . 3 # 3$ ! 3 !6 $ A B!D# .3 D2 . 3 / = d2+&& C L A B!D#63$ " " -/-$($%- -/- ,=- < < < -)(- "-3--3 *-3-3 $+4()6B!D2CA !(GI +$I 1&$&&& C F@ G+&& ` I 3 ';2@ 2) %: 48H*F1K*J% %$I > 3 +'0` O %` A6 GA. = A. . D2 = d2+&& +K. $ JD +KI 3 %: 48H*F1K*J% 4$I )66>'0@ 2) :$I +&&` F@ 2 AG!6FO!YI >3+&24& $ 1$I 66 +"D* ;$I "A B/2:'% E;%& 8$I -CA # ( AG)I]AGJDO I CAGKIX2222222222222222222222222222222222222222222222222222222222222222222222222222A+&& AG I]AGJDO I =$:(# -CAK " " & , //0 # ) 2# 2"6 G)2#"/I 3 $ 1 ` ) a 3$ ! = 3 " ) S 66 # "= '&& "6 G#. "=. - . ! I$ D +&2+ ) , C ) - $!D;.;; T / G6 $ &.' 2+I$ . / . # G#I C " "6 - ! 6 -. // 7$ ! - 3 # G# Y:.0,. 21.1,IL "6 . . $ @ 6 ++& 8&& H* '+ "6 ! 63$ - 6 ) 3 A +&& F $ ! 3 3 A #$%&&; $ ! 6 / 2 )$ & ( 10+* 6 .3 A6 G"==.-.B!DI T1C 3 G-=2%&"==I$ = 3 : - T A 3$ G= A. .JDI$@ =3 - 3T3 " 3 /3 $ # ) - "== 3 63 6 O2 3 GC 6YJDI. 3 +&&K " " 3. $ ! 3 B!D2= A B!D2# A C L = d2+&&$!A33+&&K A336 $ !3"- "A $ !/ O 3 /N2 $ @ )e&.&1G 3 ?X1KI O ! / GfI $ , A 7 . 3 = 6. B3/ L .36204H* $ ! A6 3 , 32%4H* C3 A6 ! T [ C $ A6 3 6, - 7. 3,T3 +&2+%@$ " " & - 234 * A B $ G+'';I 234 • " . • .".! .! • # . ! +01 . / / . ! .! • , 6.D 6,,%&++ • C ?# • !""E/ 2 2* .!.! • )-/ G66 O* 2BLI. +& ". 6D X 8.: G0.& O* Y%.'O%D)J:A%D%JY&.%OD%)J:Y&.%* F+.& S$I • #/ X # E / 2 2* . !.! • 6-(#.%1&"B.-B.. ! • ) 2/6 2/ ( +&&&& ) +& /6 F E &.' K O* . / 2 * . !.! • =6 G&.: KIE / 2 2* . !. ! • D)/2-// GD)/ - / / . 3F * F" I.) • =O/G=6O / I.) • EO ="/ • / AED • CED • 71& E2* g • -G48H*.1K*J%IED • G20&H*IED • ! 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F I $ ! +872 G+&2; A$ 4&.; K = A G+&28 F I A$ 0%.8 K$ / 7$ 9** 0:4>1 !" A A A A %:'''' ''''' ' B'-$*-@C 5 $+8( +872 = AG"===I, " D**28&:0.-+&&K O$ $ @ )e&.&1G 3 X1KI O$ /GfI$ $ 22(2*2(@ @3 A - , ) J 6 L. 3 2 )2 C ) "== $ ! " -=2%& "==2= [ @ O2 $ B 1&& `F , , +:.4 K . 3 G$+0I$ .*9** !" 0:4>1 %:6 5 ?-='@-/ $+0( )# A G"== =I , " -=2%& :0 . - +&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ )2 .3 +872 63. 3 O2 = A 3 C $!+&2; F +&28 F 3 D -=2%& C $ 4&K$ ! 3 O2 $ ! = A3= ,C 66 G+&2; F . +&28 F . +&20 F I. 3 +&2' F +&2+& F3$ .*9** !" 0:4>1 A A A A A %:'''' ''''' ' 5 B'-$*-@C $+'( +872 = AG"===I, " -=2%& :0 . - +&&K O$ $ @ )e&.&1G 3 X1KI O$ /GfI$ , # ''' $22(217:%( !6C )#A D @ 1 `F $ " C A 1&& `F $DC , O$ 8'.'%KG$%&I$ & 9** !" 0:4>1 A A A A A A A %:6 5 ?-='@-/ $ %&( )# A G"== =I , B2'1 :0 . - +&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ B'12% 7+872 "==2= $ +&20 F C 4.&'K$!L33 +872 . = A C $ ! +&20 F +&2+& F O$ G$%+I$ & 9** 0:4>" !" A A A A %:'''' ''''' ' 5 B'-$*-@C $%+( +872 = AG"===I, B2'1 :0 . - +&&K O$ $ @ )e&.&1 G 3 X1KI O$ /GfI$ $22(2A $ %% 3 D C 3 ) 6 1 `F A $ = C A$- 1&& `F 3 3 L , @ 18.:8 K $ +(/-D-9** 0:4>1 !" A A A A A A A %:6 5 ?-='@-/ $ %%( )# A G"== =I , 3:0.-+&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ O C +872 7 3 C @ $ 66 = A +&2; F +&28 F C A$04.%:KG$%4I$ +(/-D-9** 0:4>1 !" A A %:'''' ''''' ' 5 B'-$*-@C $%4( +872 = AG"===I, 3 :0 . - +&&K O$ $ @ )e&.&1 G 3 X1KI O$ /GfI$ , & 5' # 3 @ A. 3 +872 = A " $ 3 6 ) C , O2 $ $ *)(2?'(4 ! @ "*#28 C . 3 "==2=. C 66 $!.3 , 1 `F A $ , O2 1&&`F D C 3 40.+ K L7 $ 5 3 $/ +& `F A) %'.8%K.3 A 1&$ 9".$? 0:4>1 A #$ !" A A A A A A %:6 ?-='@-/ 5 $ %:( )# A G- =I ) " "*#28 :0 . - +&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ !C 7 +872 .3 @ -O$ 31.4%K+%8.':K +&2; F G I$ ! /3 . " 3 @ :4.; K ) G$%1I$ 3 +&2; F +&20 F . T3 C C , O2 $ ! / = / $ -3 C = A +&2; F G, 0%.&' KI +&28 F G, 0:.4%KI.3$%1 $ 9".$? #$ !" 0:4>1 A A A %:'''' ''''' ' B'-$*-@C 5 $ %1( +872 = A G"== =I ) " "*#28 :0 . - +&&K O$ $ @ )e&.&1 G 3 X1KI O$ /GfI$ $ *)(2??(4@ ! - D**28& - = , @ `F $ ! A D A 1 `F 1&& 1&& `F :1.'% K , O2 $ .$? 0:4>1 #$ !" A A A A A A A %:6 5 ?-='@-/ $ %;( )# A G- =I ) " D**28&:0.-+&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ !D**28&C =. .3 $-$ +&20 F . @ $ 53 L7 +&20 F 3$ 6 C 3 G$%8I$ = A 3 D $ C 66 +&2; F G0'.14KI+&28 F G0:.0'KI$ .$? #$ !" 0:4>1 A A A A A A %:'''' ''''' ' 5 B'-$*-@C $ %8( +872 = A G"== =I ) " D**28&:0.-+&&K O$ $ @ )e&.&1 G 3 X1KI O$ /GfI$ , , 5' $$*)(217:%( !6 B'12%3 -=. +&&21&& `F A. @ $ ! ) C 1&& `F G, 0+.:8 KI$ D A6 . L7 A B'12%G$%0.:&I$ & .$? 0:4>1 #$ !" A A A A %:6 5 ?-='@-/ $ %0( )# A G- =I ) B '12% :0 . - +&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ = 3 +&20 F B ) B'12% C $ ! , O2 14.'+K$ 3 .3 /3. O2 $ = A 3 L C 3 $!+&2; F 30:.&0K+&28 F 0&.8:K3 $ & .$? 0:4>1 #$ !" A A A %:'''' ''''' ' 5 B'-$*-@C $ %'( +872 = A G"== =I ) B '12% :0 . - +&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ $$*)(2A -2= 3. 3 $ %1 . A @ 3$ 3 - C 6 . T C 66 3 6 3 "==2= 3$ ! L7 3 L 3 1&& `F A G, 48.%8KI$! /3 , , O2 $ +(/-D-.$? 0:4>1 A #$ !" A %:6 5 ?-='@-/ $ 4&( )# A G- =I ) 3 :0 . - +&&K O$ $ @ )e&.&1 G 3 ?X1KI O$ /GfI$ / 3 3 +87 = A 3$ G+&2; F +&28 F I 3 = A6 G4+I$ +(/-D-.$? 0:4>1 #$ !" A A %:'''' ''''' ' 5 B'-$*-@C 53-> $ 4+( +872 = A G"== =I ) 3 :0 . - +&&K O$ $ @ )e&.&1 G 3 X1KI O$ /GfI$ , ( 7$)/3 ! = - C $ ! C B 3 L6 / $ $%7&(2?'(4 !" "*#283 %.1`F 1&&`F A. ="==-.$ , +&&K A C L=d2+&&.3 C LA $!%1&`F C +8.: K$ C %0.&+ K 3 1&& `F $ C L$ ! @ +872 +&2; F +&2+& F B!D# C $= A3+&2; F :'.:0K +&28 F 1%.4;KA$ $%7&(2??(4@ ! - D**28& A B +%.1;K%.1`F :0.;1`F 1&&`F $ 3 $ %8 , $ O A 3 3 A. 3 L7 C L$ 4@3 %&' !" 0:4>1 A A A A A A A A *6 ?-='@-/ E 5 $ 4%( CA )# A GB!D2=I " D**28&. :0 . - +&&K A$ C = d2+&&$ @ )e&.&1 G 3 ?X1KI O$ /GfI$ +872 =B!D2#C C L 3 $ ! L7 C 3 +&2' F +;.11 K C $ = A CA+&2; F .+&28 F .+&20 F . A @80.%'KC $+&2' F +&2+& F 3.3 $%0., C $ 4@3 %&' !" 0:41 A A A A A A A *'''' ''''' ' E B'-$*-@C 5 $ 44( CA +872 = A GB!D2=I " D**28&. :0 . - +&&K A$ C = d2+&&$ @ )e&.&1 G 3 ?X1KI O$ /GfI$ , - 7$)/3 $/7&(217:%( !A3AB'12%C $ =d2+&& $- .3$4:. C $ " CA +4.' K 1&&`F L7 B'12%C $ & 4@3 0:4>1 %&' !" A A A A A A A A *6 E ?-='@-/ 5 $ 4:( CA )# A GB!D2=I B'12%.:0.-+&&K A$ C = d2+&&$ @ )e&.&1 G 3 ?X1KI O$ /GfI$ !+872 , C $! 3 ! $ 41 $ 3 C +:.0 K G+&28 F I. , A B!D #$ = A A.3+&2; F C ;;.%KG A$I+&2+& F C ;.00KG $IL$ & 4@3 0:4>1 %&' !" A A A A A A A A A A *'''' ''''' ' E B'-$*-@C 5 $ 41( CA +872 = A GB!D2=I B'12%.:0.-+&&K A$ C = d2+&&$ @ )e&.&1 G 3 ?X1KI O$ /GfI$ $/7&(2A = 3 )# A A$ ! L7 C 6 1&& `F %4.%0K , O2 G$4;I$ +(/-D- 4@3 %&' !" 0:4>1 A A A A A A A A *6 E ?-='@-/ 5 $ 4;( CA )# A GB!D2=I 3. :0. -+&&K A$ C = d2+&&$ @ )e&.&1 G 3 ?X1KI $ /GfI$ !+8<2 A3 3$ ! = A C $ +&2; F 30%.+4K+&28 F 81.&' K C L G6 I$ ! +&20 F C 66 +&K.3C +&2' F +&2+& F 3$ , 8 70* ) -6 B'12% 6 , )# A 3$ ! - @ AG$48I$ !AO2 C @ $ C A +& `F 1& `F C . T , C 2C 2 . 3 /6 3 C $ C /6 V7V C +1&`F $!) %1& `F . 7 C $ - A A 1&& `F C $ C . 3 / $ @ C )6$ !" C $ ( )* +* )+* ,+* +** $ 48( B 6 B'12% :&&,L7 )#A:0$! $ , % 0* "6 D6 A / 3$ $ 40 7 66 $!L7 =6/ G/=I) ;:.'K$"$++.+'K ). 3 C # ) FB " . B. B ! # G)DB"YBOYB!"Y#B,I 3.3L7 $!#G#=I '.1K L7 66$ @ / B6 GB)I. GBbI. /GO*J"I.)6G))=I. /G/-I G*Db!I$ $ 40( D6 A 6 ) 2# 2 "6 $ +& 2 K $ ! 7 3T3 )-T- $ / 6X/=EX#=E6G6 X)DB"E XBOE X#B,E XB!"IE 3 G F+191;IXBJ@OE XBbE B6XB)E 6XO*J"E 66X))=E X/-EX*Db!$ ! ( ( 9 ): ! "==2= 3 , " " C $ / L , C 3$ ! - = " 3 C 3$-="7) C $ , C 3 . B'12% @ 1& `F $ 53 "==2= - = G$4'.:&IC A D 3$0& K$ -= C $ C 6. 3 )6 L7 ;& K $ ! 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