1 "Neurobiologie: Vom Molekül zum System - IAK

1 "Neurobiologie: Vom Molekül zum System - IAK

"Neurobiologie: Vom Molekül zum System" - Interdisziplinäres Seminar für Fortgeschrittene
WS 03/04
Dienstags, 15-17h
Seminarraum der Genetik, Becherweg 32, EG
Koordinator:
Joachim Urban
Institut für Genetik
Tel.: 392 43 28
e-mail: jurban@mail.uni-mainz.de
Programm:
28.10.
alle Dozenten
Vorbesprechung und Referatsverteilung
04.11.
S. Saaler-Reinhardt
Neurobiologie: Vom Molekül zum System - eine Einführung
11.11.
G.M. Technau
Bildung und Spezifizierung neuraler Stammzellen
J.M. Brown and K.G. Storey: A region of the vertebrate neural
plate in which neighbouring cells can adopt neural or epidermal
fates. Current Biology 10: 869-872 (2000)
Skeath J.B.: At the nexus between pattern formation and cell-type
specification: the generation of individual neuroblast fates in the
Drosophila embryonic central nervous system. Bioessays 21, 922-931
(1999)
18.11.
S. Saaler-Reinhardt
Stammzellen des Nervensystems: embryonal oder adult - wo ist da der
Unterschied?
P. Taupin and F. Gage (2002) Adult neurogenesis and neural stem cells of the central
nervous system in mammals J. Neurosci. Res. 69, 745-749
C. Gregg, A. Chojnacki, S. Weiss (2002) Radial glia cells as neuronal precursors: The
next generation? J. Neurosci. Res. 69, 708-713
25.11.
S. Kröger
Vom protoplasmatischen Kuss zum neuronalen Netzwerk: Synaptogenese bei
Vertebraten
Böse CM, Qiu D, Bergamaschi A, Gravante B, Bossi M, Villa A, Rupp F,
Malgaroli A (2000) Agrin controls synaptic differentiation in hippocampal
neurons. J Neurosci 20: 9086-9095.
Glass DJ, Bowen DC, Stitt TN, Radziejewski C, Bruno J, Ryan TE, Gies DR,
Shah S, Mattsson K, Burden SJ, Distefano PS, Valenzuela DM, DeChiara TM,
Yancopoulos GD (1996) Agrin acts via a MuSK receptor complex. Cell 85:
513-523.
02.12.
R. Leube
Der Transmittervesikel-Zyklus: Molekulare Grundlagen und Modellsysteme
Richmond JE, Weimer RM, Jorgensen EM. 2001. An open form of syntaxin bypasses
the requirement for UNC-13 in vesicle priming. Nature 412:338-341.
Peters C, Bayer MJ, Buhler S, Andersen JS, Mann M, Mayer A. 2001. Trans-complex
formation by proteolipid channels in the terminal phase of membrane fusion. Nature
409:581-588.
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09.12.
U. Wolfrum
Transportmechanismen und Cytoskelett in neuronalen Zellen
Sans, N et al. (2003) NMDA receptor trafficking through an interaction between PDZ
proteins and the exocyst complex. Nat Cell Biol 5:520-30.
Pazour GJ et al. (2002) The intraflagellar transport protein, IFT88, is essential for
vertebrate photoreceptor assembly and maintenance. J Cell Biol 157:103-13
16.12.
W. Hevers
Die Diversität neuronaler Ionenkanäle: Von der Postsynapse zur Präsynapse
Hodkin, Huxley & Katz (1952) Measurment of current voltage relations in the
membrane of the giant axon of Loligo. J. Physiol. 116, 424-448.
Geiger & Jonas (2000) Dynamic control of presynaptic Ca(2+) inflow by fastinactivating K(+) channels in hippocampal mossy fiber boutons. Neuron 28, 927 - 939
Brickley, Revilla, Cull-Candy, Wisden, Farrant (2001) Adaptive regulation of
neuronal excitability by a voltage-independent potassium conductance. Nature 409,
88-92
06.01.
H. Rabe
Die gabaerge inhibitorische Neurotransmission: Modulation der GABAA
Rezeptoren durch Benzodiazepine (z.B. Valium) und die Auswirkungen
RhodrijJ. Walters et al. (2000) Benzodiazepines act on GABAA receptors via two
distinct and seperable mechanisms, Nature Neuroscience 3 (12):1274-1281.
JackA. Benson et al. (1998) Pharmacology of recombinant g-aminobutyric acid A
receptors rendered diazepam-insensitive by point-mutated a-subunits. FEBS Letters
431:400-404.
Uwe Rudolph et al. (1999) Benzodiazepine actions mediated by specific gaminobutyric acid A receptor subtypes. Nature 401:796-800.
13.01.
T. Klein
Zentralnervöse Plastizität des nozizeptiven Systems: Langzeitpotenzierung
(LTP) synaptischer Übertragungsstärke als neurobiologischer Mechanismus
einer gesteigerten Schmerzwahrnehmung (Hyperalgesie)
Ikeda et al. (2003) Synaptic plasticity in spinal lamina I projection neurons that
mediate hyperalgesia. Science 299(5610):1237-40.
Klein et al. (2003) Perceptual correlates of nociceptive long-term potentiation and
long-term depression in humans. J. Neuroscience, in press
20.01.
U. Schmitt
Wie der Mensch vom/mit dem Tier lernt
J.C. Crabbe, D. Wahlsten, B.C. Dudek: Genetics of mouse behavior:
interactions with laboratory environment. Science 284 (1999) 1670 - 1672.
D. Wahlsten, N.R. Rustay, P. Metten, J.C. Crabbe: In search of a better
mouse test. TINS 26 (2003) 132 - 136.
27.01.
V. Lessmann
Sind Nervenwachstumsfaktoren diffusible Gedächtnismoleküle?
Kang, H., Welcher, A., Schuman, E.M. (1997). Neurotrophins and time: different roles for
TrkB signaling in hippocampal long-term potentiation. Neuron 19, 653-664.
Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp
HP, Bonhoeffer T, Klein R. (1999). Essential role for TrkB receptors in hippocampusmediated learning. Neuron 24(2):401-14.
Kovalchuk Y, Hanse E, Kafitz KW, Konnerth A. (2002). Postsynaptic Induction of BDNF-
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Mediated Long Term Potentiation. Science 295(5560):1729-34.
Hintergrundinformation:
Poo, M-M. (2001) Neurotrophins as synaptic modulators. Nat. Rev. Neurosci. 2, 2432.
Lessmann V, Gottmann K, Malcangio M. (2003). Neurotrophin secretion: current
facts and future prospects. Prog Neurobiol. 69(5):341-74.
03.02.
R. Spessert
Tageszeitliche und jahreszeitliche Periodizität beim Säuger
Li et al. (1998) Molecular rhythms in the rat pineal. Current Opinion in Neurobiology
8: 648-651, 1998
Malpaux et al. (2001) Biology of mammalian photoperiodism and the critical role of
the pineal gland and melatonin. J. Biol. Rhythms 16: 336-347, 2001
10.02.
H. Luhmann
Epilepsie: Vom Kanal zum neuronalen Netzwerk
McCormick DA, Contreras D (2001) On the cellular and network bases of epileptic
seizures. Annu Rev Physiol 63: 815-846.
Owens DF, Kriegstein AR (2001) Maturation of channels and receptors:
consequences for excitability. Int Rev Neurobiol
45: 43-87.
17.02.
F. Fahrenholz
Eiweißablagerungen als Ursache neurodegenerativer Erkrankungen
Walsh et al. (2001) Amyloid-ß oligomers: their production, toxicity and therapeutic
inhibition. Biochem. Soc. Trans. 30, 552-55.
Hetz, C., Maundrell, K. and Soto, C. (2003) Is loss of function of the prion protein
the cause of prion disorders? Trends Molec. Med. 9(6), 237-243.
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