Leitliniengerechte Therapie von Halsschmerzen in der Apotheke

Leitliniengerechte Therapie von Halsschmerzen in der Apotheke

Übersicht
Leitliniengerechte Therapie von
Halsschmerzen in der Apotheke
Ludger Klimek und Annette Sperl, Wiesbaden
Literatur
1. Bachert C, et al. Aspirin compared with acetaminophen in the treatment of
fever and other symptoms of upper respiratory tract infection in adults: a
multicenter, randomized, double-blind, double-dummy, placebo-controlled,
parallel-group, single-dose, 6-hour dose-ranging study. Clin Ther 2005;27:993–
1003.
2. Bereznoy VV, et al. Efficacy of extract of Pelargonium sidoides in children
with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a
randomized, double-blind, placebo-controlled trial. Altern Ther Health Med
2003;9:68–79.
3. Bisno AL, Gerber MA, Gwaltney JM Jr., Kaplan EL, et al. Practice guidelines
for the diagnosis and management of group A streptococcal pharyngitis. Clin
Infect Dis 2002;35:113–25.
4. Bisno AL, Kaplan EL. Strep throat over and over: how frequent? How real?
Mayo Clin Proc 2006;81:1153–4.
5. Blagden M, et al. Multidose flurbiprofen 8.75 mg lozenges in the treatment of
sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres. Int J Clin Pract 2002;56:95–100.
6. Burnett I, et al. Onset of analgesia of a paracetamol tablet containing sodium
bicarbonate: A double-blind, placebo-controlled study in adult patients with
acute sore throat. Clin Ther 2006;28:1273–8.
7. Carapetis JR. The current evidence for the burden of group A streptococcal
diseases. Discussion papers on child health (WHO/FCH/CAH/05.07). 2005:
1–52.
8. Chenot JF, et al. Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis.
BMC Fam Pract 2014;15:45.
9. Chrubasik S, et al. Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat. Eur Arch Otorhinolaryngol 2012;269:571–7.
10. Dagnelie C, et al. Do patients with sore throat benefit from penicillin? A randomized double-blind placebo-controlled clinical trial with penicillin V in
general practice. Br J Gen Pract 1996;46:589–93.
11. de Mey C, et al. Efficacy and safety of ambroxol lozenges in the treatment of
acute uncomplicated sore throat. EBM-based clinical documentation. Arzneimittelforschung 2008;58:557–68.
12. de Mey C, et al. Efficacy and Safety of an Oral Ambroxol Spray in the Treatment of Acute Uncomplicated Sore Throat. Drug Res (Stuttgart) 2015 Mar 17.
[Epub ahead of print].
13. DEGAM-Leitlinie Nr. 14. Halsschmerzen. Stand Oktober 2009, gültig bis
01.10.2014
14. Eccles R, et al. Effects of acetylsalicylic acid on sore throat pain and other pain
symptoms associated with acute upper respiratory tract infection. Pain Med
2003;4:118–24.
15. Evans CE, et al. Sore throats in adults: who sees a doctor? Can Fam Physician
1982;28:453–8.
16. Fachinformation Dobendan Direkt Flurbiprofen 8,75 mg Lutschtabletten,
Stand: Januar 2015.
17. Fischer J, et al. Efficacy and tolerability of ambroxol hydrochloride lozenges in
sore throat. Randomised, double-blind, placebo-controlled trials regarding the
local anaesthetic properties. Arzneimittelforschung 2002;52:256–63.
18. Fokkens, et al. European Position Paper on Rhinosinusitis and Nasal Polyps
2012. Rhinol Suppl 2012;23:3 p preceding table of contents, 1–298.
19. Hannaford PC, Simpson JA, Bisset AF, et al. The prevalence of ear, nose and throat problems in the community: results from a national cross-sectional postal
survey in Scotland. Fam Pract 2005;22:227–33.
20. Hubbert M, et al. Efficacy and tolerability of a spray with Salvia officinalis in
the treatment of acute pharyngitis – a randomised, double-blind, placebocontrolled study with adaptive design and interim analysis. Eur J Med Res
2006;11:20–6.
21. McNally D, et al. Rapid relief of acute sore throat with AMC/DCBA throat
lozenges: randomised controlled trial. Int J Clin Pract 2010;64:194–207.
**1 MMP 38. Jahrgang 12 / 2015
22. Moore N, et al. Tolerability of ibuprofen, aspirin and paracetamol for the
treatment of cold and flu symptoms and sore throat pain. Int J Clin Pract
2002;56:732–4.
23. Risikobewertungsverfahren. Fusafungin (Locabiosol®): Einleitung eines europäischen Risikobewertungsverfahrens aufgrund einer steigenden Anzahl
schwerer Überempfindlichkeitsreaktionen (https://www.bfarm.de/SharedDocs/Risikoinformationen/Pharmakovigilanz/DE/RV_STP/a-f/fusafungin_locabiosol.html (Zugriff am 29.10.2015).
24. Russo M, et al. Flurbiprofen microgranules for relief of sore throat: a randomised, double-blind trial. Br J Gen Pract 2013;63:e149–55.
25. Schachtel B, et al. Onset of action of a lozenge containing flurbiprofen 8.75 mg:
a randomized, double-blind, placebo-controlled trial with a new method for
measuring onset of analgesic activity. Pain 2014;155:422–8.
26. Schachtel B, et al. Utility of the sore throat pain model in a multiple-dose assessment of the acute analgesic flurbiprofen: a randomized controlled study.
Trials 2014;15:263.
27. Schachtel BP, et al. Caffeine as an analgesic adjuvant. A double-blind study
comparing aspirin with caffeine to aspirin and placebo in patients with sore
throat. Arch Intern Med 1991;151:733–7.
28. Schachtel BP, et al. Sore throat pain in the evaluation of mild analgesics. Clin
Pharmacol Ther 1988;44:704–11.
29. Schutz A, et al. Local anaesthetic properties of ambroxol hydrochloride lozenges in view of sore throat. Clinical proof of concept. Arzneimittelforschung
2002;52:194–9.
30. Spinks A, et al. Antibiotics for sore throat. Cochrane Database Syst Rev
2013;11:CD000023. doi: 10.1002/14651858.CD000023.pub4.
31. Thomas M, et al. How effective are treatments other than antibiotics for acute
sore throat? Br J Gen Pract 2000;50:817–20.
32. van Driel, et al. Are sore throat patients who hope for antibiotics actually asking for pain relief? Ann Fam Med 2006;4:494–9.
33. Vincent MT, Celestin N, Hussain AN. Pharyngitis. Am Fam Physician
2004;69:1465–70.
34. Wächtler H, Chenot JF. Die neue DEGAM-Leitlinie Halsschmerzen. Zeitschrift
für Allgemeinmedizin 2010;86:65–9.
35. Watson N, et al. Relief of sore throat with the anti-inflammatory throat lozenge
flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of
efficacy and safety. Int J Clin Pract 2000;54:490–6.
36. Wonnemann M, et al. Lidocaine 8 mg sore throat lozenges in the treatment
of acute pharyngitis. A new therapeutic option investigated in comparison to
placebo treatment. Arzneimittelforschung 2007;57:689–97.
37. Zwart S, et al. Penicillin for acute sore throat: randomised double blind
trial of seven days versus three days treatment or placebo in adults. BMJ
2000;320:150–4.
38. Zwart S, et al. Penicillin for acute sore throat in children: randomised, double
blind trial. BMJ 2003;327:1324–30.
Prof. Dr. med. Ludger Klimek, Zentrum für Rhinologie und
Allergologie, An den Quellen 10, 65183 Wiesbaden,
E‑Mail: ludger.klimek@hno-wiesbaden.de
Annette Sperl, Zentrum für Rhinologie und Allergologie, An den
Quellen 10, 65183 Wiesbaden