Annual Report 2014 - Berliner Institut für Gesundheitsforschung

Annual Report 2014 - Berliner Institut für Gesundheitsforschung

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Annu
Table of contents
3Foreword
42014 Highlights
6 On the Road to a New Charité
12 2014 in Numbers
16
Health Services
17
Research
18
Education and Teaching | Training
19 Organizational Structure
20 Overview of Medical Facilities and Institutes
Selected Publications 2014
Legal notice
Publisher Corporate Communications Division, Charité – Universitätsmedizin Berlin
Tel. +49 30 450 570 400 | presse@charite.de | www.charite.de
Responsible as per Press Law Uwe Dolderer, Head of Corporate Communications Division
Proofing Dr. Julia Biederlack, Nancy Janz, Verena Wolff, Manuela Zingl
Editing Dr. Katja Furthmann
Translations English Express
Design Christine Voigts
Zentrale Mediendienstleistungen, Charité – Universitätsmedizin Berlin
Photos Wiebke Peitz, Zentrale Mediendienstleistungen, Charité – Universitätsmedizin Berlin
Beatrice Staib (page 4, middle left), Jens Jeske (page 4, middle right),
Randy Tarango (page 5, bottom left), Stephan Baumann (page 5, bottom left),
Schweger Architekten (page 8, top left),
Sabine Gudath (page 8, top right), picture alliance / dpa (page 10, top left)
Frontispiece: Construction work on the new façade of the main ward (CCM)
2
Foreword
Professorial appointments, construction projects, the Ebola virus, staffing changes and positive
annual results: these are the keywords that best describe 2014 at the Charité – Universitätsmedizin Berlin.
By appointing numerous renowned doctors, the Charité has significantly strengthened its work
in cardiology, tumor and transplantation surgery, gynecology, and sports medicine. In addition,
Prof. Dr. Thomas Südhof, a laureate of the Nobel Prize in Physiology or Medicine, will be spending
three years with the Charité as an Einstein BIH Visiting Fellow at the Berlin Institute of Health.
There were also changes in key administrative departments. Evelyn Möhlenkamp replaced Hedwig
François-Kettner as Nursing Director in February. The Faculty Council elected Prof. Dr. Axel R. Pries
as Dean in December. He took over from Prof. Dr. Annette Grüters-Kieslich.
The Charité’s largest construction project began in January with the handing over of keys to the
general contractor. The project will fully renovate and modernize the main ward building, which
dates back to 1982. The cornerstone ceremony for the new building that will stand on the eastern
side of the 21-storey ward building was held in September. Berlin’s then mayor, Klaus Wowereit, was
in attendance. Once finished, the building will house operating theaters, intensive care medicine
and emergency medicine.
Campus Charité Mitte is not the only Charité location to be benefiting from building work. The
new emergency diesel generator at Campus Virchow-Klinikum has gone into operation, and the
1960s operating theaters on Campus Benjamin Franklin are undergoing extensive renovations.
The new rooms for the Department of Psychiatry and Psychotherapy have also been completed.
In response to the outbreak of Ebola in West Africa, the Charité has put numerous preparatory
measures in place. Doctors and nurses attended Germany’s biggest isolation unit at Campus
Virchow-Klinikum for intensive, regular training on how to handle a potential emergency.
For many years now, the Charité has been addressing its role in Germany’s National Socialist era.
The GeDenkOrt.Charité – Science and Social Responsibility project is part of these efforts. Last
year, six memorial columns were installed across three of the Charité’s four campuses, displaying
the biographies of employees who were forced into exile.
The Charité enjoyed a successful year in 2014. Focus magazine’s nationwide hospital ranking
crowned it Germany’s Best Hospital for the third year in a row. It also closed 2014 with a positive
operating result for the fourth year running. This year’s profits totaled €7.6 million. Given the increasingly difficult financial situation facing university hospitals in Germany, we are very pleased
with this successful outcome. It would not have been possible without the spirit of cooperation
and the daily efforts of the some 16,800 employees working throughout the Charité. For this, we
would like to extend our warmest thanks. In 2015, our shared commitment will continue to be the
basis for developing the Charité further and securing its success.
Prof. Dr. Karl Max Einhäupl
Chairman of the Board
Prof. Dr. Axel R. Pries
Dean
Matthias Scheller
Hospital Director
Prof. Dr. Ulrich Frei
Medical Director
3
New Nursing Director: Evelyn Möhlenkamp takes over from
Hedwig François-Kettner
Health sector convenes for high-level meeting: The Charité
attends the Medicine and Health congress in Berlin
Comfort for parents of preemies: Dr. Eckart von Hirschhausen
opens a new parents’ room in the neonatology department
Health education for all: The Charité’s XXL Sunday lecture
focuses on dementia, cancer, rheumatism and osteoarthritis
Makeover for the main ward façade: 2,068 aluminum elements
give the building a bright new look
Building in Mitte: Cornerstone ceremony marks the start of a
new home for surgery, intensive care and emergency medicine
Unusual patients: Germany’s health minister, Hermann Gröhe,
visits the stuffed toy clinic at the Charité
Joining forces for university hospitals: The Charité participates
in a nationwide campaign week
Germany’s biggest health study: The Charité opens the National
Cohort’s Berlin-Mitte study center
Latest clinical diagnostics: High-resolution imaging with three
new magnetic resonance imaging systems
Charity for Charité: Benefit gala for children with serious chronic
and rare diseases
Christmas music on every campus: The CharitéBrass-Band
plays Christmas songs for staff and patients
On the Road
to a New Charité
2014 was an eventful and groundbreaking year for the
and Director of the Department of Cardiology at the DHZB.
Charité – Universitätsmedizin Berlin. Many topics and pro-
These appointments are also very important from a research
jects were initiated or continued and all of them helped to
perspective, as the professors will provide a major boost for
move the Charité forward. Once again, for example, the
the clinical cardiovascular research being performed at the
Charité succeeded in attracting renowned doctors and re-
Berlin Institute of Health. The cross-institutional collabora-
searchers from around the world.
tion between Berlin’s new heart specialists, and closer links
between clinical and experimental research will strengthen
Top-Flight Doctors Appointed
Prof. Dr. Johann Pratschke became Director of the Depart-
translational medicine in the German capital overall. In their
capacity as teachers, the cardiologists will also make an important contribution to training the next generation of doctors.
ment for General, Visceral and Transplantation Surgery in
June. This puts Prof. Dr. Patschke, a specialist in tumor and
transplantation surgery, at the head of the largest depart-
Raising the Bar in Sports Medicine
ment in the Charité. The role involves leading and restructu-
Olympic doctor Prof. Dr. Bernd Wolfarth was appointed Medical
ring the surgical departments at Campus Virchow-Klinikum
Director of the new sports medicine department and university
and Campus Charité Mitte.
outpatient clinic in September. This means the Charité is one
of the few hospitals in Germany to have an interdisciplina-
The Department of Gynecology and the Breast Center also
ry, clinically oriented university outpatient facility for sports
underwent structural changes. Prof. Dr. Jens-Uwe Blohmer
medicine. Prof. Dr. Wolfarth has also been professor of sports
became the new Director of the Department of Gynecology
medicine at Humboldt-Universität zu Berlin since 2014.
at Campus Charité Mitte in September. He also heads the
Charité’s Breast Center at all three locations. The Department of Gynecology at Campus Virchow-Klinikum and at
New Managers
Campus Benjamin Franklin continues to be run by Prof. Dr.
Last year saw further staffing changes at the managerial
Jalid Sehouli, who became a tenured professor in 2014.
level in the Charité. Evelyn Möhlenkamp became the new
Nursing Director and a member of the Charité’s Clinical Cen-
This year also saw three world-renowned cardiologists leave
ter Management in February. She takes over from Hedwig
positions in Europe to take up roles at the Charité and bring
François-Kettner, who stepped down as planned after more
their expertise to its cardiovascular departments. Prof. Dr. Ulf
than 30 years in the role. Andrea Schmidt-Rumposch was ap-
Landmesser became the new Director of the Department of
pointed Deputy Nursing Director. Prof. Dr. Adelheid Kuhlmey,
Cardiology at Charité Campus Benjamin Franklin in October.
Director of the Institute of Medical Sociology and Rehabili-
The winter semester saw Prof. Dr. Volkmar Falk take up a pro-
tation Science, became the new Vice Dean for Education in
fessorship for cardiac surgery at the Charité in cooperation
May after a vote by the Faculty Council. She took over from
with the Deutsches Herzzentrum Berlin (DHZB). He is also
Prof. Dr. Claudia Spies after she stepped down. The exis-
the DHZB’s new Medical Director and heads its Department
ting Vice Dean for Research, Prof. Dr. Christian Hagemeier,
of Cardiothoracic and Vascular Surgery. Prof. Dr. Burkert
was confirmed in office. Prof. Dr. Axel R. Pries, Director of
Pieske came to Berlin in November to serve as Director of
the Institute of Physiology, was elected Dean by the Faculty
the Department of Cardiology at Campus Virchow-Klinikum
Council in December.
6
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17
100
Locations
Charité Centers
almost
Hospitals and Institutes
He took over from Prof. Dr. Annette Grüters-Kieslich, who had
the interior of the 21-story ward building started at the same
served as Dean and a member of the Executive Board from
time as the removal of the old façade. Work on renovating the
2008 until she stepped down at the end of 2014.
20,500 m2 façade started later in the year, on time and as
planned. The bright new unitized façade features high-quality
Driving Translation
insulation that makes for a more energy-efficient building.
The Berlin Institute of Health (BIH) was set up by the Charité
The new building on the eastern side of the ward building
and the Max Delbrück Center for Molecular Medicine Berlin-
is also progressing on schedule and within budget. The cor-
Buch as a facility for pooling their translational research. The
nerstone ceremony was held in September. Some 100 guests
institute is designed to promote the translation of research
attended the celebrations, among them Klaus Wowereit,
findings into clinical application for the benefit of patients,
the then mayor of Berlin, and Sandra Scheeres, chair of the
and to investigate clinical questions in the laboratory. This
Supervisory Board at the Charité and senator for Education,
makes it the first facility in Germany to adopt a holistic,
Youth and Science. The work on the main ward building also
systems-medical approach. The BIH successfully launched
includes replacing the bridge over Luisenstraße, which con-
its first major research projects and a number of key in-
nects the ward with the historic campus. The new bridge will
frastructure measures in 2014. Thanks to support from the
be made of steel and glass and will feature a light, transpa-
Private Excellence Initiative Johanna Quandt, whose funds
rent design. The whole master-plan project is expected to
are managed by the Charité Foundation, Prof. Dr. Thomas
be completed at the end of 2016.
Südhof will be spending the next three years at the BIH as
an Einstein BIH Visiting Fellow. A Stanford professor and lau-
Last year also saw a great deal of activity on construction
reate of the Nobel Prize in Physiology or Medicine, Prof. Dr.
sites at the other locations. Construction teams are hard at
Südhof will be working on a neuroscience project in which he
work extensively renovating the 1960s operating theaters on
will investigate how neurons in the brain communicate with
Campus Benjamin Franklin. The project is being carried out
one another and how diseases disrupt this communication.
in two construction phases while work continues in the theaters. This master-plan project, which is also on schedule and
Master-Plan Projects at all Locations
within budget, should be complete in 2016. The new rooms for
the Department of Psychiatry and Psychotherapy on Campus
Some of the Charité’s key construction projects are part
Benjamin Franklin – also part of the Charité’s master-plan –
of the master-plan that the Berlin Senate agreed in 2010.
were completed in December 2014 and went into use in Janu-
The Senate has made a total of €376.5 million available for
ary 2015. This meant that the Charité could give up another
renovating and improving critical structures.
external location and significantly improve its patient care
structure. The master-plan’s emergency diesel power project
The Charité launched its largest master-plan project in Ja-
at Campus Virchow-Klinikum was completed in December.
nuary 2014 with a symbolic handing over of keys to the ge-
The state-of-the-art high-voltage switchgear is housed in
neral contractor, a consortium of Ed. Züblin AG and VAMED
its own building and is equipped with two emergency diesel
Deutschland. The main ward building at the Mitte location will
generators that can be used to support the existing power
be modernized and a new building erected for surgery, inten-
supply. The commissioning of the system is part of a project
sive care medicine and emergency medicine. Work on gutting
to restructure the site’s entire electricity supply.
7
Germany’s Best Hospital
The German magazine Focus awarded the title of Germany’s
be responsible for the medical management of the center.
Best Hospital to the Charité when it published its national
The aim is to provide optimum patient care by combining a
hospital ranking in September 2014. The Charité thus suc-
municipal care structure with university expertise.
cessfully defended its title, which it has held for the past
few years, and at the same time set new quality standards
for the future. The Focus list is based on Germany’s most
Outstanding Surgical Achievement
comprehensive quality comparison, which reviews more than
Surgeons successfully reattached the arm of a 30-year-old
1,000 hospitals across the country. The Charité achieved out-
man in an operation that lasted around seven hours. The me-
standing results in most of the 16 areas included in the study.
dical team successfully performed a rare macroreplantation
of the right arm, which had been severed eight centimeters
The Family-Friendly Charité
above the elbow. The high quality of the emergency medical
care provided by the paramedics was key to the success of
In June, the Charité was awarded familiengerechte hochschu-
the operation. The arm’s blood supply was restored just 3.5
le (Family-Friendly University) and berufundfamilie (Family-
hours after the accident. The patient has been making an
Friendly Workplace) certification after it successfully completed
excellent recovery. To fully restore the functions of his hand
the corresponding audits. This was the third time in a row that
and fingers, surgeons will have to carry out further operations,
it had received the certification, in recognition of its sustainable
such as transplanting neural tracts. The doctors estimate that
initiatives for helping staff combine working and family life. It
it will take more than two years for the nerves to grow and for
received particular praise for giving parents access to a wide
the patient to regain full movement in his hand and fingers.
range of childcare options, even in unforeseen situations.
The Charité has expanded its commitment even further and
Robot Surgeons
currently collaborates with six children’s day-care centers.
The Charité began using the latest generation of the da
Flexible working hours for nurses, and formats such as job
Vinci robot for complex surgical interventions in January.
sharing and working from home are also well established
This makes it one of the few hospitals in Berlin and Branden-
at the Charité.
burg to have access to this innovative surgical technology.
Numerous new features allow the system to perform opera-
Partnership with Vivantes
tions with outstanding precision and the utmost safety. It can
drastically reduce the occurrence of unwanted side effects.
The Charité and Vivantes are expanding their partnership.
Once Labor Berlin had established itself as a successful joint
In contrast to conventional keyhole surgery, doctors using
venture, work on building the radiotherapy center at the
the da Vinci system benefit from high-definition 3D vision
Vivantes hospital in Friedrichshain also made swift progress.
and instruments that allow complete freedom of movement.
The shell of the building was completed in December. This
When operating in tight spaces, such as in urological, thora-
means the project, which is expected to cost €9 million, is
cic and colorectal-cancer surgery, it is especially helpful for
on schedule and within budget. The building should be ready
surgeons to have three instrument arms at their disposal
for use by the middle of 2015. The new rooms will feature
and the ability to guide the camera themselves.
state-of-the-art equipment and technology. The Charité will
8
First Mobile CT Scanner
In May, the Charité became the first hospital in Europe to
They will each benefit from a monthly grant of €300 for
have a mobile computer tomography (CT) scanner. The
a period of at least one year. The grants are funded by
new device can scan patients while they are undergoing
the German government and private sponsors, who each
neurosurgery – and even sitting up. This allows the surgeon
provide half of the total.
to update important diagnostic 3D data at any time during
surgery and check, for instance, whether a tumor has been
completely removed. The ring-shaped high-tech device also
National Cohort
means that the Charité can now produce 3D images of the
The Charité began participating in the National Cohort in
entire spine, and it is faster, gentler and more accurate
September, when it opened a study center in Berlin-Mitte.
than other scanners. Before its arrival, surgery patients
Entitled “Joint Research for a Healthier Future”, the National
had to be moved to a stationary scanner in the radiology
Cohort is Germany’s largest-ever national population study
department before doctors could evaluate the outcome of
and will examine around 200,000 people over the next 20
the operation.
to 30 years. The large-scale project is receiving €210 million
in funding from the German government, the participating
Cardiac Arrest Center
states and the Helmholtz Association. The aim is to improve
research into widespread diseases such as cancer, diabetes
Each year, over 75,000 people in Germany suffer cardiac
and cardiovascular diseases, so as to enhance their preven-
arrest and have to be resuscitated. Just 5,000 of them
tion and therapy.
survive this dangerous cardiac event. In order to improve
patients’ survival chances, the Charité opened the country’s
first center of excellence for cardiac arrests in July. It de-
Powerful Research
livers fast, specialized treatment to those who have been
The Charité proved once again in 2014 that it is a research
resuscitated after suffering a cardiac arrest. This involves
powerhouse. This was reflected in the decision of the Ger-
quickly identifying the cause of the arrest and rapidly re-
man Research Foundation (DFG) to extend two Collaborative
ducing the patient’s body temperature, as this has been
Research Centres / Transregios that are coordinated by the
proven to reduce neurological damage. The aim is to use
Charité. The scientists involved are investigating how innate
standardized procedures and treatment in hospitals with
or acquired immune responses can be used to treat pneu-
specialized cardiac arrest centers to significantly increase
monia and cancer. The DFG also approved a new research
the number of people who survive a cardiac arrest with a
group that will spend the next three years investigating which
good neurological prognosis.
factors cause bones to heal more slowly in old age.
Funding for Dedicated Students
The faculty applied for DFG funding for five large-scale research devices in 2014. The applications were approved and
In April 2014, the Charité awarded 40 new Germany Schol-
the faculty received around €1.2 million from the DFG to
arships to selected students pursuing programs in medicine
fund the devices.
and dentistry and other health-related fields. In addition to
their outstanding academic achievements, the recipients
The German Federal Ministry of Education and Research
also demonstrated a strong commitment to civil society.
(BMBF) is funding the national research group CAPSyS
9
(Systems Medicine of Community-Acquired Pneumonia) for
tients in Hamburg and Frankfurt, while others have traveled
three years. The financing totals €3.8 million. The Charité is
to West Africa to work with aid organizations on the ground.
receiving €1.4 million of that for its research into how seri-
The Ebola epidemic was also the subject of a symposium
ous or fatal forms of pneumonia can be identified early and
that was held at the sixth World Health Summit in October
what can be done to significantly improve the progression
and organized in cooperation with Germany’s foreign office
of the disease.
and health ministry. International experts and the German government’s special envoy for Ebola, Walter Lindner,
The Charité is participating in the BMBF’s research network
used the special event to call for a coordinated approach,
on mental illnesses. It is involved in seven groups and coordi-
sustainable infrastructure on the ground, and support for
nates the addiction research group. The nationwide research
international aid workers. The World Health Summit was
network is receiving €35 million in funding and will spend
held under the patronage of German chancellor Angela
the next four years doing intensive research into the causes,
Merkel, French president François Hollande, and European
diagnosis and treatment of mental illnesses.
Commission president José Manuel Barroso. Around 1,200
international representatives from academia, the private
As part of its nationwide research network, the BMBF is also
sector, politics and civil society discussed strategies for
funding three large-scale collaborative projects on diseases
solving the medical challenges facing the world today.
of the musculoskeletal system. They are being led by the
Charité. The projects aim to advance research, networking
between experts, and treatment options for conditions such
GeDenkOrt.Charité
as rheumatism, osteoporosis and back pain.
The GeDenkOrt.Charité – Science and Social Responsibility
project addresses the role, past and present, of medicine
The Charité submitted ten successful applications for the
and science in society. The initiative is designed to help the
EU’s “Horizon 2020” research and innovation program in
institution confront its own past and also to raise awareness
2014. The fields included the neurosciences, cardiology,
of current ethical dilemmas. Two important elements of this
gastroenterology, rheumatology, and medical nanotech-
project were initiated in 2014: the foundation Friede Springer
nology. It also received an ERC Starting Grant for medical
Stiftung will fund a Medical Humanities guest professorship
psychology.
at the Charité, and the support organization Freundeskreis
der Charité is helping set up an Info Box to inform the public
The Ebola Epidemic
about the origins and objectives of the GeDenk.Ort project.
The Ebola epidemic in West Africa was a top issue for the
In addition, two memorial columns have now been installed
world and the Charité last year. The university hospital has
at each of the hospital locations. The columns bear the na-
set up Germany’s largest isolation unit at Campus Virchow-
mes of the more than 180 employees who are known to
Klinikum. Numerous selected medical staff are undergoing
have been forced into exile during the National Socialist era
intensive, regular training there so that they will be able
and provide more detailed information on the lives of six of
to respond if an emergency does arise. In addition, several
these individuals.
doctors and nurses from the Charité helped treat Ebola pa-
10
120 Years of Pediatrics
The Charité had an important event to celebrate in Novem-
for children with rare diseases, the journey to a diagnosis
ber: the 120th anniversary of Germany’s first chair for pe-
alone can be an odyssey that lasts many years and involves
diatrics, which was established in Berlin in 1894. This date
numerous hospital stays and uncertainties. For the Charité’s
has always been considered as marking the birth of modern
plans to succeed, its children’s departments need financial
pediatric and adolescent medicine. Otto Heubner, Germany’s
support from dedicated donors.
first full professor of pediatrics, helped turn the field into an
independent academic discipline. Heubner was also director
The Charity for Charité benefit gala that was held in Decem-
of the Charité’s children’s hospital, which was founded in
ber raised over €100,000. Jörg Thadeusz was the host for the
1829. In collaboration with leading doctors and scientists
evening, which featured a diverse program and a slogan that
of his time, Heubner made significant progress in, among
called for “better health for our children”. The main event
other things, reducing infant mortality. To this day, children
of the gala was an auction run by lawyer and art enthusiast
benefit from the close links between research and care in
Prof. Dr. Peter Raue. The guests included Eva Luise Köhler,
Berlin. All nine children’s departments at the Charité take a
patron of the Alliance for Chronic Rare Diseases (ACHSE),
multiprofessional, interdisciplinary approach to collaborating
designer Jette Joop, and Jörg Woltmann, sole shareholder
on medical care and research.
of the Königliche Porzellan-Manufaktur Berlin (KPM).
A Thank-You for Generous Support
Radio Berlin 88.8 also used its 2014 Christmas fundraising
campaign to help improve treatment for children with seri-
The Charité relies on donations for many projects that go
ous chronic and rare diseases. Its listeners donated a total
beyond its legal obligations to provide medical care. In June,
of €127,000 to the project. Anyone who donated €5 or more
as a way of expressing its thanks for the generosity of many
took part in a prize draw to win one of 24 premium Berlin-
dedicated supporters, the Charité laid clinker bricks engraved
made products.
with donors’ names at the entrance to the children’s departments on Campus Virchow-Klinikum. They are designed to
The Charité, designer Jette Joop, and KPM also launched
symbolize the shared path to better children’s health. During
a joint project to support the children’s departments. Joop
the ceremony, Prof. Dr. Karl Max Einhäupl personally thanked
created a special winged heart design for 101 KPM Cadre
everyone, on behalf of the Executive Board and the depart-
vases and painted the first one herself. The profits will go to-
ments, who has helped the Charité in this way.
wards improving the lives of the Charité’s youngest patients.
Help for Seriously Ill Children
Improving care for young patients who suffer from serious
chronic and rare diseases is a project that is very close to
the hearts of the staff working in the children’s departments
at the Charité. The Charité wants to do more in this area
and develop an appropriate care structure of a standard
that does not yet exist anywhere in Germany. Particularly
11
2014
in Numbers
Profitability
Investments
The Charité – Universitätsmedizin Berlin comprises around
The Charité invested a total of €125.8 million in tangible
100 departments and institutes spread across four loca-
fixed assets and intangible fixed assets during the fiscal
tions: Campus Benjamin Franklin, Campus Berlin-Buch,
year. These investments were funded in large part by the
Campus Charité Mitte and Campus Virchow-Klinikum. The
state of Berlin, with €33.7 million in general investment sub-
Charité has a total of about 16,800 employees in medical
sidies from the state being used for teaching, research and
care, research and teaching, service, administration, and
medical care.
third-party funding. This makes the Charité one of the biggest employers in the German capital.
In fiscal year 2014, the Charité generated total revenue of
more than €1.5 billion (including investment grants), with
revenue of €848.4 million coming from more than 139,000
inpatient and semi-inpatient cases and over 656,000 outpatient cases.
On the expenses side, personnel costs represent the largest
item. They totaled €766.2 million, increasing €20.4 million
from the year before. The cost of materials rose €9.7 million to €402.8 million. Other operating expenses stood at
€201.0 million, of which €69.4 million was for maintenance.
Net income for fiscal year 2014 was €7.6 million. It is the
fourth consecutive time that the Charité has posted positive results for the year, and another year of beating
the ambitious target set out in its business plan. It has
thus stayed the course of economic consolidation for yet
another year. The continued economic improvement of
the Charité is largely thanks to the outstanding dedication of all Charité employees in implementing the program of reforms adopted several years ago.They have
enabled the implementation of a comprehensive portfolio of structural improvements to achieve greater efficiency. As a result, the Charité managed to offset and
overcompensate for the effects of collective-bargaining
agreements and inflation as well as additional liabilities
resulting from extensive construction work.
12
2008
2009 2010
-17,8
-19.2
8.2
1.6*
5.2
7.6
2011201220132014
* Figure without special effect;
result 2013 including special effect of
the dissolution of third party funding
obligations: € 36.3 million
-56.6
PROFIT AND LOSS STATEMENT
Revenue**
Changes in inventories
2013
in T€
2014
in T€
816,190848,444
-19925
Subsidies from public funds
197,903201,801
Other operating income
338,743359,783
1.352,6381.410,053
Personnel expenses
745,729766,158
Cost of materials
393,127
Interim result
213,781241,093
402,802
Result from subsidized items related to hospital operations 133,37063,825
Depreciation, amortisation and write-downs
Other operating expenses
Interim result
84,93573,326
211,266200,999
50,95030,594
Financial result
Result from ordinary activities
-13,277-16,941
37,673
13,653
Extraordinary expense
3,9595,883
Result from taxes
2,588-183
Net income for the year including special effect of third party funding obligations
Net income for the year without special effect
of third party funding obligations
36,303
7,587
1,5937,587
** Revenue is defined as proceeds
from hospital services, optional
medical services, outpatient services, and revenues from elective
procedures conducted by physicians.
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



























13.100 Charité Staff members*
of those
4.135 Nursing staff 220 Professors
BALANCE SHEET ASSETS
31 Dec 2013
in T€
31 Dec 2014 in T€
A. Fixed assets
I. Intangible fixed assets
II. Tangible assets
III. Long-term financial assets
1,6834,867
1.129,9611.161,660
3,6423,663
1.135,2861.170,190
B. Current assets
I. Inventories
II. Receivables and other assets III. Cash-in-hand, state central bank balances,
bank balances 50,47548,388
252,305257,092
86,40690,436
389,185395,916
C. Deferred charges
3,8623,860
1.528,3331.569,966
EQUITY AND LIABILITIES
A. Equity
1. Capital
2. Revenue reserves
3. Accumulated losses brought forward
164,346163,665
1,80036,510
-176,016-174,424
4. Net income 36,3037,587
26,43233,339
B. Special reserves for financing fixed assets 930,390
959,539
C. Provisions
326,668
344,582
D. Liabilities
238,002
228,767
6,841
3,739
E. Deferred income
14
1.528,3331.569,966

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

















































3.700 Scientists and physicians
31%
Personnel
69%
710 Administrative staff
* including Berlin Institute of Health; all figures are rounded
CHANGES IN STAFFING LEVELS
Active full-time staff (FT) total
ø FT
2013
ø FT
2014
Development
of fte
9,609.29,502.6
6.2
Medical services
2,075.72,059.6
-16.1
Nursing services
2,437.72,411.4
-26.3
Medical-technical services
2,465.72,408.4
-57.3
Functional services
1,125.21,128.7
of those:
3.5
Operating and supply services
369.1372.8
3.7
Technical services
203.6202.4
-1.2
Administrative services
778.4759.6
-18.8
Special services
96.4100.5
4.1
Staff training services
57.459.3
1,9
Inactive full-time staff
1,230.41,176.2
Active full-time staff (externally funded)
1,548.41,554.6
Full-time staff total
12,388.112,233.4
-54.3
6.2
-154.7
Students
302.2306.1
4.0
Midwife trainees
38.737.3
-1.4
Trainees
91.691.4
-0.3
Interns
1.70.0 -1.7
15
Sclerodermia
Consultation for rare diseases
Age-related macular degeneration
Polyposis syndrome
Muscle disease
Early onset arthritis
Memory
Immunodeficiency
Amyotrophic lateral sclerosis (ALS)
SpeCial
CONSULTING
HOURS
Anaplastology
Ataxia
Consultation for rare diseases
Psoriasis
Hyperhidrosis
Short bowel syndrome Transplantation Surgery
Movement disorders
Adult autism
Health services
2013
total
2014
total
TOP
NATIONALES
Number of officially authorized beds
3,0113,011
Beds available
3,0113,011
Utilization rate (average number of available beds in %)
83.483.4
Average occupancy in days 6.05
6.05 Occupancy days 881,981
881,981 Inpatient cases 136,440
136,440 Outpatient cases
637,171637,171
KRANKENHAUS
2015
number 1
Charité
DEUTSCHLANDS
GRÖSSTER
KRANKENHAUSVERGLEICH
250
200
200
182
174
204
198
193
187
201
195
163
159
150
150
127
130
130
133
136
139
140
136
139
117
00
casemix points
50
50
Inpatient cases
100
100
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
Number of cases and casemix points, in thousands
16
Clinic Ranking
(Focus 20|2014)
DFG Graduate Schools
2
Research Centers, including
12 7Collaborative
with host function
2
Clinical Research
Groups
projects, including
5 3Excellence
with host function
5
DFG Research
Groups
3
Federal Research Ministry
Competency Networks
Research
47.6 million euros
German Research
Foundation (DFG)
27.7 million euros
Industry
Focus of research activities
• Immunological science
34.9 million euros
Federal Ministry
• Cardiovascular research
and metabolism
•Neuroscience
•Oncology
150.7 million euros
procured external
funding
• Regenerative therapies
• Rare diseases and genetics
13.1 million euros
European Union
13.1 million euros
Foundations
12.5 million euros
Donations and Other
1.9 million euros
Land of Berlin
million
euros
300
300
250
250
258
255
251
245
240
229
216
203
200
200
190
151
150
150
50
50
00
130
88
97
98
108
101
105
116
153
154
148
199
151
127
state grants
external funding
100
100
177
195
189
184
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Development of state consumption subsidies and external revenue
17
Model Medicinal Studies
Molecular Medicine
Consumer Health Care
Cerebrovascular Medicine
Dentistry
Public Health
Medical Neurosciences – International Graduate Program
UNIVERSITY
CURRICULUM
Epidemiology
Applied Epidemiology
Health and Society:
International Gender Studies Berlin
BA in Health Science
Standard Medical Studies
Reformed Medical Curriculum
Education and teaching
Students, total
Number of degree courses
First-year students, total
December
2013
December
2014
6,9536,906
1719
1,3891,461
of whom:
Medicine
697709
Dentistry
102100
Health science
Other
6664
524588
Graduates, total *
771744
of whom:
Medicine 607614
Dentistry
8473
Health science
8057
* without Master
OCCUPATIONAL TRAINING
Occupational training at the Health Academy 571 traineeships in 8 different healthcare professions
Midwifery
Healthcare and nursing
Healthcare and pediatric nursing
Surgical-technical assistant
Nutrition assistant
Logopedics
Physiotherapy Autopsy and preparation assistants
Further qualified occupatients
Medical assistant
Animal technician
Administrative assistant
Dental assistant
Biology lab assistant
Office assistant
Information systems assistant
18
Organizational structures
Medical Faculty Senate
Chairman: Prof. Dr. Peter-André Alt
and Prof. Dr. Jan-Hendrik Olbertz
Office: Dr. Gerda Fabert
Supervisory Board
Chairwoman: Sandra Scheeres
Faculty Council
Chairman:
Prof. Dr. Axel R. Pries
Office of the Supervisory Board:
Dr. Jan Steffen Jürgensen
Office: Heike Stein
EXECUTIVE BOARD
Chairman of the Executive Board
Prof. Dr. Karl Max Einhäupl
Hospital Director
Matthias Scheller
Medical Director
Prof. Dr. Ulrich Frei
Dean
Prof. Dr. Axel R. Pries
Executive Secretary of the Board
Dr. Jan Steffen Jürgensen
Clinical Center Management
Matthias Scheller (Hospital Director)
Prof. Dr. Ulrich Frei (Medical Director)
Evelyn Möhlenkamp (Nursing Director)
Dr. Helmar Wauer (Hospital Business Director)
Faculty Board
Prof. Dr. Axel R. Pries (Dean)
Prof. Dr. Christian Hagemeier
(Vice Dean for Research)
Prof. Dr. Adelheid Kuhlmey
(Vice Dean for Education)
Fabian Hempel (Faculty Business Director)
CHARITÉCENTERS
CC1
CC2
CC3
CC4
CC5
CC6
CC7
CC8
CC10
CC11
CC12
CC13
CC14
CC15
CC16
CC17
CC9
BUSINESS DIVISIONS
Technology
and Operations
Toralf Giebe
Buildings
and Grounds
Management
Christian Kilz
Academy
Finance and
Purchasing
Dr. Marianne Rabe
Carsta Prütz
Dr. Alexander
Hewer
Office for
Hospital
Negotiations with Management
Health Insurance
Companies
Carsta Prütz
Marie le Claire
Corporate
Controlling
Strategic
Human
Corporate
Resources
Development
Matthias
Roland Kurney Wiemann (acting) Christof Schmitt
Corporate
Communications
IT
Corporate
Governance
Uwe Dolderer
Helmut Greger
Marc Deffland
Pharmacy
Legal Services
Dr. Susan
Bischoff
Christof Schmitt
Research
Thomas Gazlig
Central
Academic and
International
Academic Affairs
Burkhard Danz Dr. Mathias John
Study Affairs
SPIN-OFFS AND HOLDINGS
ZTB Zentrum für Transfusionsmedizin und Zelltherapie Berlin gemeinnütziger GmbH
Labor Berlin – Charité Vivantes Services GmbH
Labor Berlin – Charité Vivantes GmbH
Charité CFM Facility Management GmbH
CRO Charité Research Organisation GmbH
Charité Healthcare Services GmbH
Charité Physiotherapie- und Präventionszentrum GmbH
Ambulantes Gesundheitszentrum der Charité GmbH
Medizinisches Versorgungszentrum der Charité Mitte GmbH
WHS Foundation GmbH
Last update:
February 2015
19
Overview of the clinics and institutes
CC1 CharitéCenter for Health and Human Sciences
Scientific Director
Prof. Dr. Adelheid Kuhlmey +49 30 450 529 171
adelheid.kuhlmey@charite.de
Managing Director
Dr. Sabine Damm
+49 30 450 529 181
sabine.damm@charite.de
Director
Institute of General Medicine
Dr. Christoph Heintze (acting)
Institute of Occupational Medicine
Prof. Dr. Adelheid Kuhlmey (acting)
Institute of the History of Medicine and Ethics in Medicine
Prof. Dr. Volker Hess
Institute of Healthcare Research
TBA
Institute of Health and Nursing Science
Prof. Dr. Michael Ewers
Institute of Medical Psychology
Prof. Dr. Christine Heim
Institute of Medical Sociology and Rehabilitation Science
Prof. Dr. Adelheid Kuhlmey
Institute of Sexology and Sexual Medicine
Prof. Dr. Klaus Beier
Institute of Social Medicine, Epidemiology and Health Economics
Prof. Dr. Stefan Willich
Berlin School of Public Health
Prof. Dr. Jacqueline Müller-Nordhorn
CC2 CharitéCenter for Basic Sciences
Scientific Director
Prof. Dr. Britta Eickholt
+49 30 450 539 121 britta.eickholt@charite.de
Managing Director
Thomas Gazlig
+49 30 450 528 181
thomas.gazlig@charite.de
Director
Specialty Network: Anatomy
Institute of Integrative Neuroanatomy
Prof. Dr. Imre Vida
Institute of Vegetative Anatomy
Prof. Dr. Sebastian Bachmann
Institute of Cell Biology and Neurobiology
Prof. Dr. Victor Tarabykin (acting)
Specialty Network: Biochemistry and Molecular Biology
Institute of Biochemistry
Prof. Dr. Britta Eickholt
Institute of Molecular Biology and Bioinformatics
Prof. Dr. Britta Eickholt (acting)
Institute of Biochemistry and Molecular Biology
Prof. Dr. Britta Eickholt
Institute of Medical Physics and Biophysics
Prof. Dr. Christian Spahn
Specialty Network: Physiology
Institute of Physiology
Prof. Dr. Axel R. Pries
Institute of Neurophysiology
Prof. Dr. Jörg Geiger
Institute of Vegetative Physiology
Prof. Dr. Pontus B. Persson
CC3 CharitéCenter for Dental, Oral and Maxillary Medicine
Scientific Director
Prof. Dr. Paul-Georg Jost-Brinkmann+49 30 450 562 522 paul-g.jost-brinkmann@charite.de
Managing Director
Manfred Datta
+49 30 450 562 001
manfred.datta@charite.de
Director
Institute for Dental, Oral and Maxilary Medicine
Prof. Dr. Paul-Georg Jost-Brinkmann
CC4 CharitéCenter for Therapy and Research
Scientific Director
Prof. Dr. Josef Köhrle
+49 30 450 524 021
josef.koehrle@charite.de
Managing Director
Thomas Gazlig
+49 30 450 528 181
thomas.gazlig@charite.de
Director
Specialty Network: Pharmacology and Toxicology
Institute of Clinical Pharmacology and Toxicology
Prof. Dr. Ulrich Kintscher
Institute of Pharmacology
Prof. Dr. Reinhold Kreutz
Specialty Network: Biometry, Epidemiology and Medical Computer Science
Institute of Medical Biometrics and Clinical Epidemiology
Prof. Dr. Josef Köhrle (acting)
Institute of Medical Informatics
Prof. Dr. Thomas Tolxdorff
Institute of Theoretical Biology Prof. Dr. Hans-Peter Herzel
Institute of Experimental Endocrinology
Prof. Dr. Josef Köhrle
Associated: Gender in Medicine (GIM)
Prof. Dr. Vera Regitz-Zagrosek
CC5 CharitéCenter for Diagnostic Laboratory and Preventive Medicine
Medical Director
Prof. Dr. Rudolf Tauber
+49 30 8445 2555
rudolf.tauber@charite.de
Managing Director
Sina Wesoly
+49 30 450 569 392
sina.wesoly@charite.de
Managing MTA
Sigrid Kersten
+49 30 450 525 189
sigrid.kersten@charite.de
Director
Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry
Prof. Dr. Rudolf Tauber
Institute of Microbiology and Hygiene
Prof. Dr. Ulf Göbel
Institute of Virology | CBF
Prof. Dr. Regine Heilbronn
Institute of Virology | CCM Prof. Dr. Detlev Krüger
Institute of Legal Medicine and Forensic Sciences
Prof. Dr. Michael Tsokos
Institute of Forensic Psychiatry
Prof. Dr. Hans-Ludwig Kröber
Institute of Pathology
Prof. Dr. Manfred Dietel
Institute of Hygiene and Environmental Medicine
Prof. Dr. Petra Gastmeier
CC6 CharitéCenter for Diagnostic and Interventional Radiology and Nuclear Medicine
Medical Director
Prof. Dr. Bernd Hamm
+49 30 450 527 082
bernd.hamm@charite.de
Managing Director
Arne Weber
+49 30 450 527 091
arne.weber@charite.de
Managing MTRA
Susanne Ortmann
+49 30 450 557 071
susanne.ortmann@charite.de
Director
Institute of Radiology (including Pediatric Radiology and Neuroradiology)
Prof. Dr. Bernd Hamm
Department of Nuclear Medicine
Prof. Dr. Winfried Brenner
20
Institute of Neuroradiology
Prof. Dr. Bernd Hamm (acting)
CC7 CharitéCenter for Anesthesiology and Intensive Care Medicine
Medical Director
Prof. Dr. Claudia Spies
+49 30 450 531 012
claudia.spies@charite.de
Managing Director
Dr. Matthes Seeling
+49 30 450 651 121
matthes.seeling@charite.de
Nursing Director
Timo Bechtel
+49 30 450 577 048
timo.bechtel@charite.de
Director
Department of Anesthesiology and Operative Intensive Care Medicine | CCM | CVK Prof. Dr. Claudia Spies
Department of Anesthesiology and Operative Intensive Care Medicine | CBF
Prof. Dr. Christoph Stein
CC8 CharitéCenter for Surgery
Medical Director
Prof. Dr. Kurt Miller
+49 30 8445 2575
kurt.miller@charite.de
Managing Director
Axel Köhler
+49 30 450 522 001
axel.koehler@charite.de
Nursing Director
Annett Leifert
+49 30 450 552 524
annett.leifert@charite.de
Director
Department of General, Visceral, Vascular and Thoracic Surgery | CCM Dr. Oliver Haase (acting)
Department of General, Visceral and Transplantation Surgery | CVK
Prof. Dr. Johann Pratschke
Department of General, Visceral and Vascular Surgery | CBF
Prof. Dr. Martin E. Kreis
Department of Urology
Prof. Dr. Kurt Miller
CC9 CharitéCenter for Orthopedics and Traumatology
Medical Director
Prof. Dr. Norbert Haas
+49 30 450 552 012
norbert.haas@charite.de
Managing Director
Dipl.-Kfm. Gerald Linczak
+49 30 450 552 728
gerald.linczak@charite.de
Nursing Director
Stefanie Bieberstein
+49 30 450 577 051
stefanie.bieberstein@charite.de
Director
Department of Traumatology and Reconstructive Surgery Prof. Dr. Norbert Haas
inculding Department of Orthopedic Surgery | CVK | CCM
Julius Wolff Institut of Biomechanics and Musculoskeletal Regeneration
Prof. Dr.-Ing. Georg Duda
Department of Traumatology and Reconstructive Surgery | CBF
Prof. Dr. Wolfgang Ertel
Department of Oral and Maxillofacial Surgery Prof. Dr. Dr. Bodo Hoffmeister
CC10 Charité Comprehensive Cancer Center
Medical Director
Prof. Dr. Ulrich Keilholz (acting) +49 30 450 513 501
ulrich.keilholz@charite.de
Managing Director
Dr. Regina Jünger
+49 30 450 540 011 regina.juenger@charite.de
Director
Charité Comprehensive Cancer Center
Prof. Dr. Ulrich Keilholz (acting)
CC11 CharitéCenter for Cardiovascular Diseases
Medical Director
Prof. Dr. Gert Baumann
+49 30 450 513 072 gert.baumann@charite.de
Managing Director
Dipl.-Kfm. Gerald Linczak +49 30 450 552 728
gerald.linczak@charite.de
Nursing Director
Stefanie Bieberstein
+49 30 450 577 051 stefanie.bieberstein@charite.de
Director
Department of Cardiology | CBF
Prof. Dr. Ulf Landmesser
Department of Cardiovascular Surgery
Prof. Dr. Wolfgang Konertz
Medical Department, Division of Cardiology and Angiology | CCM Prof. Dr. Gert Baumann
Medical Department, Division of Cardiology | CVK
Prof. Dr. Burkert Pieske
CC12 CharitéCenter for Internal Medicine and Dermatology
Medical Director
Prof. Dr. Gerd-Rüdiger Burmester+49 30 450 513 061
gerd.burmester@charite.de
Managing Director
Fred Vock
+49 30 450 513 201
fred.vock@charite.de
Nursing Director
Barbara Jung
+49 30 450 677 026
barbara.jung@charite.de
Director
Medical Department, Division of Rheumatology and Clinical Immunology | CCM
Prof. Dr. Gerd-Rüdiger Burmester
(including Physical Medicine) | CBF | CCM
Medical Department, Division of Infectiology and Pneumonology | CCM / | CVK
Prof. Dr. Norbert Suttorp
(including Outpatient Pneumology)
Medical Outpatient | CCM Prof. Dr. Jürgen Scholze
Department of Dermatology, Venerology and Allergology
Prof. Dr. Torsten Zuberbier (acting)
Institute of Medical Immunology
Prof. Dr. Hans-Dieter Volk
Medical Department, Division of Psychosomatic Medicine
Prof. Dr. Matthias Rose
CC13 CharitéCenter for Internal Medicine with Gastroenterology and Nephrology
Medical Director
Prof. Dr. Bertram Wiedenmann +49 30 450 553 022
bertram.wiedenmann@charite.de
Managing Director
Volker Schnittger +49 30 450 513 181
volker.schnittger@charite.de
Nursing Director
Dagmar Hildebrand
+49 30 450 577 368
dagmar.hildebrand@charite.de
Director
Specialty Network: Nephrology
Medical Department, Division of Nephrology and Internal Intensive Care Medicine | CVK Prof. Dr. Achim Jörres (acting)
Medical Department, Division of Nephrology | CCM
Prof. Dr. Klemens Budde
Department of Nephrology | CBF
Prof. Dr. Walter Zidek
21
Specialty Network: Gastroenterology, Endocrinology and Metabolic Diseases
Medical Department, Division of Hepatology and Gastroenterology | CVK | CBF
Prof. Dr. Bertram Wiedenmann
(including Metabolic Diseases)
Department of Gastroenterology, Infectiology and Rheumatology | CBF Prof. Dr. Britta Siegmund (acting)
(including Nutrition Medicine)
Department of Endocrinology and Metabolic Diseases Prof. Dr. Joachim Spranger
(including Division of Lipid Metabolism)
Institute of Clinical Physiology
TBA
Emergency Department | CBF
Prof. Dr. Rajan Somasundaram
Emergency Departments | CVK | CCM
Prof. Dr. Martin Möckel
CC14 CharitéCenter for Tumor Medicine
Medical Director
Prof. Dr. Bernd Dörken +49 30 450 553 111
bernd.doerken@charite.de
Managing Director
Dr. Felix Mehrhof +49 30 450 513 274
felix.mehrhof@charite.de
Nursing Director
Judith Heepe
+49 30 450 577 098
judith.heepe@charite.de
Director
Medical Department, Division of Oncology and Hematology | CCM Prof. Dr. Hanno Riess
Medical Department, Division of Hematology, Oncology | CBF Prof. Dr. Antonio Pezzutto
Medical Department, Division of Hematology, Oncology and Tumor Immunology | CVK Prof. Dr. Bernd Dörken
Department of Radiation Oncology and Radiotherapy | CCM | CVK Prof. Dr. Volker Budach
Department of Radiation Oncology and Radiotherapy | CBF
Prof. Dr. Volker Budach
Institute of Immunology
Prof. Dr. Thomas Blankenstein
Institute of Transfusion Medicine Prof. Dr. Abdulgabar Salama
CC15 CharitéCenter for Neurology, Neurosurgery and Psychiatry
Medical Director
Prof. Dr. Matthias Endres
+49 30 450 560 101
matthias.endres@charite.de
Managing Director
PD Dr. Uwe Reuter +49 30 450 560 274
uwe.reuter@charite.de
Nursing Director
Sinah Krueger
+49 30 450 677 035 sinah.krueger@charite.de
Director
Department of Neurology with Experimental Neurology
Prof. Dr. Matthias Endres
Department of Psychiatry and Psychotherapy | CCM
Prof. Dr. Andreas Heinz
Department of Psychiatry and Psychotherapy | CBF
Prof. Dr. Isabella Heuser-Collier
Department of Neurosurgery with Pediatric Neurosurgery
Prof. Dr. Peter Vajkoczy Institute of Neuropathology
Prof. Dr. Frank Heppner
CC16 CharitéCenter for Audiology / Phoniatrics, Ophthalmology and Otolaryngology
Medical Director
Prof. Dr. Manfred Gross +49 30 450 555 401
manfred.gross@charite.de
Managing Director
Christoph Wigger +49 30 450 555 161
christoph.wigger@charite.de
Nursing Director
Diane Jetschmann
+49 30 450 577 118 diane.jetschmann@charite.de
Director
Department of Ophthalmology Prof. Dr. Antonia Joussen
Department of Otolaryngology
Site Management CVK | CCM
Prof. Dr. Heidi Olze
Site Management CBF
PD Dr. Minoo Lenarz
Department of Audiology and Phoniatrics
Prof. Dr. Manfred Gross
CC17 CharitéCenter for Gynecology, Perinatal, Pediatric and Adolescent Medicine with Perinatal Center and Human Genetics
Medical Director
Prof. Dr. Ulrike Lehmkuhl +49 30 450 566 202
ulrike.lehmkuhl@charite.de
Managing Med. DirectorPD Dr. Uwe Reuter +49 30 450 566 321
uwe.reuter@charite.de
Managing Director
Juliane Kaufmann +49 30 450 566 341
juliane.kaufmann@charite.de
Nursing Director
Judith Heepe
+49 30 450 577 098
judith.heepe@charite.de
Sinah Krüger
+49 30 450 677 035 sinah.krueger@charite.de
Director
Specialty Network: Perinatal Medicine
Department of Obstetrics
Prof. Dr. Wolfgang Henrich
Department of Neonatology
Prof. Dr. Christoph Bührer
Further Facilities
Department of Gynecology with Center for Oncological Surgery
Prof. Dr. Jalid Sehouli
Department of Gynecology with Breast Center of the Charité | CCM
Prof. Dr. Jens-Uwe Blohmer
Department of Gynecology | CV | CBF Prof. Dr. Jalid Sehouli (CBF acting)
Specialty Network: Pediatrics and Youth Medicine
Department of Pediatrics, Endocrinology and Diabetology
Prof. Dr. Annette Grüters-Kieslich
Department of Pediatrics Endocrinology, Gastroenterology and Metabolic Medicine Prof. Dr. Angelika Eggert (acting)
Department of Pediatrics, Division of Cardiology
Prof. Dr. Felix Berger
Department of Pediatrics, Division of Pneumonology and Immunology
Prof. Dr. Bodo Niggemann (acting)
and Intensive Medicine including Emergency Department
Department of Pediatrics, Division of Oncology and Hematology Prof. Dr. Angelika Eggert
Department of Pediatrics, Division of Nephrology Prof. Dr. Uwe Querfeld
Department of Pediatrics, Division of Neurology
Prof. Dr. Christoph Hübner
Department of Pediatric Surgery
Prof. Dr. Karin Rothe
Center for Social Pediatrics
Dr. Theodor Michael
Department of Child and Adolescent Psychiatry, Psychosomatic Medicine Prof. Dr. Ulrike Lehmkuhl
and Psychotherapy
Institute of Experimental Pediatric Endocrinology
Prof. Dr. Heiko Krude
Further Facilities
Institute of Medical Genetics Prof. Dr. Bernhard Herrmann
Institute of Medical Genetics and Human Genetics
Prof. Dr. Stefan Mundlos
22
Last update: March 2015
Ausgewählte Publikationen 2014*
Selected Publications 2014*
CC1 für Human- und Gesundheitswissenschaften
Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Simhan HN, Wadhwa PD.
Maternal estriol (E3) concentrations in early gestation predict
infant telomere length. Journal of Clinical Endocrinology &
Metabolims. 2014 Oct 22:jc20142744.
Grabenhenrich L, Gough H, Reich A, Eckers N, Zepp F, Nitsche O, Forster
J, Schuster A, Schramm D, Bauer CP, Hoffmann U, Beschorner J, Wagner P, Bergmann RL, Bergmann KE, Matricardi PM, Wahn U, Laus S, Keil
T. Early life determinants of asthma from birth to age 20: a German birth cohort study. J Allergy Clin Immunol 2014;133(4):979-88.
Hess V, Mendelsohn A. Sauvages‘ paperwork: how disease classification arose from scholarly note-taking. Early Sci Med. 2014;19
(5):471-503.
Muckelbauer R, Barbosa CL, Mittag T, Burkhardt K, Mikelaishvili N,
Müller-Nordhorn J. Association between water consumption und
body weight outcomes in children and adolescents: a systematic
review. Obesity. 2014; 22(12):2462-75.
Douros A, Schlemm L, Bolbrinker J, Ebinger M, Kreutz R. Insufficient
anticoagulation with dabigatran in a patient with short bowel
syndrome. Thromb Haemost. 2014 Aug;112(2):419-20.
Lauer D, Slavic S, Sommerfeld M, Thöne-Reineke C, Sharkovska Y, Hallberg A, Dahlöf B, Kintscher U, Unger T, Steckelings UM, Kaschina E.
Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor
of matrix metalloproteinase 1/matrix metalloproteinase 9 axis
and transforming growth factor ß1 in the rat heart. Hypertension.
2014 Mar;63(3):e60-7.
Lück S, Thurley K, Thaben PF, Westermark PO. Rhythmic degradation
explains and unifies circadian transcriptome and proteome data.
Cell Rep. 2014 Oct 23;9(2):741-51.
Schweizer U, Schlicker C, Braun D, Köhrle J, Steegborn C. Crystal
structure of mammalian selenocysteine-dependent iodothyronine
deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10526-31.
Schauber SK, Schalk L. Matters of detail - does basic science content
support future learning? Medical Education. 2014; 48 (7): 650-652.
CC5 für diagnostische und präventive Labormedizin
CC2 für Grundlagenmedizin
Dernedde J, Weise C, Müller EC, Hagiwara A, Bachmann S, Suzuki M,
Reutter W, Tauber R, Scherer H. Cupulin is a zona pellucida-like
domain protein and major component of the cupula from the
inner ear. PLoS ONE. 2014;9(11):e111917.
Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJ, Mielke
T, Ismer J, Hildebrand PW, Tung CS, Nierhaus KH, Sanbonmatsu KY,
Spahn CM. Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement. Cell.
2014 Jul 3;158(1):121-31.
Frielingsdorf S, Fritsch J, Schmidt A, Hammer M, Löwenstein J, Siebert
E, Pelmenschikov V, Jaenicke T, Kalms J, Rippers Y, Lendzian F,
Zebger I, Teutloff C, Kaupp M, Bittl R, Hildebrandt P, Friedrich B, Lenz
O, Scheerer P. Reversible [4Fe-3S] cluster morphing in an O(2)tolerant [NiFe] hydrogenase. Nat Chem Biol. 2014 May;10(5):378-85.
Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la
Vega M, Ninnemann O, Schindler D, Damatova N, Eirich K, Sifringer M,
Schrötter S, Eickholt BJ, van den Heuvel L, Casamina C, StoltenburgDidinger G, Ropers HH, Wienker TF, Hübner C, Kaindl AM. Mutations
in PTRH2 cause novel infantile-onset multisystem disease with
intellectual disability, microcephaly, progressive ataxia, and
muscle weakness. Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35.
Hüser D, Gogol-Döring A, Chen W, Heilbronn R. Adeno-associated
virus type 2 wild-type and vector-mediated genomic integration
profiles of human diploid fibroblasts analyzed by third-generation
PacBio DNA sequencing. J Virol. 2014 Oct;88(19):11253-63.
Loibl S, von Minckwitz G, Schneeweiss A, Paepke S, Lehmann A, Rezai
M, ZahmDM, Sinn P, Khandan F, Eidtmann H, Dohnal K, Heinrichs C,
Huober J, Pfitzner B, Fasching PA, Andre F, Lindner JL, Sotiriou C,
Dykgers A, Guo S, Gade S, Nekljudova V, Loi S, Untch M, Denkert C.
PIK3CA mutations are associated with lower rates of pathologic
complete response to anti-human epidermal growth factor
receptor 2 (her2) therapy in primary HER2-overexpressing
breast cancer. J Clin Oncol. 2014 Oct 10;32(29):3212-20.
Raftery MJ, Lalwani P, Krautkrämer E, Peters T, Scharffetter-Kochanek
K, Krüger R, Hofmann J, Seeger K, Krüger DH, Schönrich G. Beta2 integrin mediates hantavirus-induced release of neutrophil
extracellular traps. J. Exp. Med. 2014 Jun 30; 211(7):1485-97.
Srivatsa S, Parthasarathy S, Britanova O, Bormuth I, Donahoo AL,
Ackerman SL, Richards LJ, Tarabykin V. Unc5C and DCC act
downstream of Ctip2 and Satb2 and contribute to corpus
callosum formation. Nat Commun. 2014 Apr 17;5:3708.
Ruhnke M, Arnold R, Gastmeier P. Infection control issues in patients
with haematological malignancies in the era of multidrugresistant bacteria. Lancet Oncol 2014; 15:e606-19.
Yamamoto H, Unbehaun A, Loerke J, Behrmann E, Collier M, Bürger J,
Mielke T, Spahn CM. Structure of the mammalian 80S initiation
complex with initiation factor 5B on HCV-IRES RNA. Nat Struct
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CC6 für diagnostische und interventionelle Radiologie
und Nuklearmedizin
CC3 für Zahn-, Mund- und Kieferheilkunde
Braun J, Guo J, Lützkendorf R, Stadler J, Papazoglou S, Hirsch S, Sack I
& Bernarding J. High-resolution mechanical imaging of the human
brain by three-dimensional multifrequency magnetic resonance
elastography at 7T. Neuroimage. 2014;90:308-14.
Radlanski RJ. An equilibrating splint combined with active orthodontic
screw segments for the initial treatment of patients with a
posterior forced bite. J of Craniomandibular Function. 2014; (6) 117-129.
Elgeti T, Knebel F, Hättasch R, Hamm B, Braun J & Sack I. Shear-wave
amplitudes measured with cardiac MR elastography for diagnosis
of diastolic dysfunction. Radiology. 2014;271(3):681-7. 6,214.
Rafayelyan S, Meyer P, Radlanski RJ, Minden K, Jost-Brinkmann PG, Präger
TM. Effect of methotrexate upon antigen-induced arthritis of the
rabbit temporomandibular joint. J Oral Pathol Med. 2014 Sep 22.
Haeckel A, Appler F, Figge L, Kratz H, Lukas M, Michel R, Schnorr J, Zille
M, Hamm B & Schellenberger E. XTEN-annexin A5: XTEN allows
complete expression of long-circulating protein-based imaging
probes as recombinant alternative to PEGylation. J Nucl Med.
2014;55(3):508-14.
Schwendicke F, Dörfer CE, Schlattmann P, Page LF, Thomson WM, Paris S.
Socioeconomic inequality and caries: a systematic review and
meta-analysis. J Dent Res. 2015 Jan;94(1):10-8.
Strietzel FP, Neumann K, Hertel M. Impact of platform switching on
marginal peri-implant bone level changes. A systematic review
and meta-analysis. Clin Oral Implants Res 2014. Epub 2014 Jan 20.
Walter MH, Marré B, Vach K, Strub J, Mundt T, Stark H, Pospiech
P, Wöstmann B, Heydecke G, Kern M, Hartmann S, Luthardt R,
Huppertz J, Wolfart S, Hannak W. Management of shortened dental
arches and periodontal health: 5-year results of a randomised
trial. J Oral Rehabil. 2014 Jul;41(7):515-22.
CC4 für Therapieforschung
Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M,
Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB,
Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ;
STEMO Consortium. Effect of the use of ambulance-based
thrombolysis on time to thrombolysis in acute ischemic stroke:
a randomized clinical trial. JAMA. 2014 Apr 23-30;311(16):1622-31.
Schilling R, Jastram B, Wings O, Schwarz-Wings D & Issever AS. Reviving the dinosaur: virtual reconstruction and three-dimensional
printing of a dinosaur vertebra. Radiology. 2014;270(3):864-71.
Walther S, Schueler S, Tackmann R, Schuetz G.M, Schlattmann P &
Dewey M. Compliance with STARD checklist among studies
of coronary CT angiography: systematic review. Radiology.
2014;271(1):74-86.
CC7 für Anästhesiologie und Intensivmedizin
Feldheiser A, Hunsicker O, Krebbel H, Weimann K, Kaufner L, Wernecke
KD & Spies C. Oesophageal Doppler and calibrated pulse contour
analysis are not interchangeable within a goal-directed haemodynamic algorithm in major gynaecological surgery? Brit J
Anaesth. 2014;1:4-5.
Kumpf O, Bloos F, Bause H, Brinkmann A, Deja M, Marx G, Kaltwasser A,
Dubb R, Muhl E, Greim CA, Weiler N, Chop I, Jonitz G, Schaefer H,
Felsenstein M, Liebeskind U, Leffmann C, Jungbluth A, Waydhas C,
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Pronovost P, Spies C, Braun JP & NeQuI-Group (Netzwerk Qualität in
der Intensivmedizin). Voluntary peer review as innovative tool for
quality improvement in the intensive care unit - a retrospective
descriptive cohort study in German intensive care units. Ger Med
Sci. 2014;12:Doc17.
Luetz A, Balzer F, Radtke FM, Jones C, Citerio G, Walder B, Weiss B,
Wernecke KD, Spies C. Delirium, sedation and analgesia in the
intensive care unit: a multinational, two-part survey among
intensivists. PLoS One. 2014 Nov 14;9(11):e110935.
Nachtigall I, Tafelski S, Günzel K, Uhrig A, Powollik R, Tamarkin A, Wernecke
KD & Spies C. Standard operating procedures for antibiotic therapy
and the occurrence of acute kidney injury: a prospective, clinical,
non-interventional, observational study. Crit Care. 2014;18(3):R120.
Schmidt M, Neuner B, Kindler A, Scholtz K, Eckardt R, Neuhaus P
& Spies C. Prediction of long-term mortality by preoperative
health-related quality-of-life in elderly onco-surgical patients.
PLoS ONE. 2014;9(1):e85456.
CC8 für Chirurgische Medizin
Busch J, Seidel C, Goranova I, Erber B, Peters R, Friedersdorff F,
Magheli A, Miller K, Grünwald V, Weikert S. Categories of response
to first line vascular endothelial growth factor receptor targeted
therapy and overall survival in patients with metastatic renal
cell carcinoma. Eur J Cancer. 2014 Feb;50(3):563-9.
Friedersdorff F, Manus P, Miller K, Lein M, Jung K, Stephan C. Serum
testosterone improves the accuracy of Prostate Health Index
for the detection of prostate cancer. Clin Biochem. 2014 Jul;47
(10-11):916-20.
Gerlach UA, Atanasov G, Wallenta L, Polenz D, Reutzel-Selke A, Kloepfel
M, Jurisch A, Marksteiner M, Loddenkemper C, Neuhaus P, Sawitzki B,
Pascher A. Short-term TNF-alpha inhibition reduces short-term and
long-term inflammatory changes post-ischemia/reperfusion in rat
intestinal transplantation. Transplantation. 2014 Apr 15;97(7):732-739.
Struecker B, Raschzok N, Sauer IM. Liver support strategies:
cutting-edge technologies. Nat Rev Gastroenterol Hepatol. 2014
Mar;11(3):166-176.
Zurbuchen U, Schwenk W, Junghans T, Modersohn D, Haase O. Vaguspreserving technique during minimally invasive esophagectomy:
the effects on cardiac parameters in a swine model. Surgery. 2014
Jul;156(1):46-56.
CC9 für Orthopädie und Unfallchirurgie
Klatte-Schulz F, Gerhardt C, Scheibel M, Wildemann B, Pauly S.
Relationship between muscle fatty infiltration and the biological characteristics and stimulation potential of tenocytes
from rotator cuff tears. J Orthop Res. 2014 Jan;32(1):129-37.
Kleber C, Giesecke MT, Lindner T, Haas NP, Buschmann CT. Requirement
for a structured algorithm in cardiac arrest following major
trauma: epidemiology, management errors, and preventability of
traumatic deaths in Berlin. Resuscitation. 2014 Mar;85(3):405-1.
Mihailescu R, Furustrand Tafin U, Corvec S, Oliva A, Betrisey B, Borens O,
Trampuz A. High activity of fosfomycin and rifam-pin against
methicillin-resistant Staphylococcus aureus (MRSA) biofilm in
vitro and in experimental foreign-body infection model. Antimicrob
Agents Chemother 2014; 58: 2547-53.
Pfitzner T, Abdel MP, von Roth P, Perka C, Hommel H. Small improvements in mechanical axis alignment achieved with MRI versus
CT-based patient-specific instruments in TKA: a randomized
clinical trial. Clin Orthop Relat Res. 2014 Oct;472(10):2913-22.
von Roth P, Abdel MP, Wauer F, Winkler T, Wassilew G, Diederichs G,
Perka C. Significant muscle damage after multiple revision total
hip replacements through the direct lateral approach. Bone Joint
J. 2014 Dec;96-B(12):1618-22.
CC10 Charité Comprehensive Cancer Center
Berger A, Quast SA, Plötz M, Kuhn NF, Trefzer U, Eberle J. RAF
inhibition overcomes resistance to TRAIL-induced apoptosis
in melanoma cells. J Invest Dermatol. 2014 Feb;134(2):430-40.
Denkert C, von Minckwitz G, Brase JC, Sinn BV, Gade S, Kronenwett R, Pfitzner BM, Salat C, Loi S, Schmitt WD, Schem C, Fisch K,
Darb-Esfahani S, Mehta K, Sotiriou C, Wienert S, Klare P, André F,
Klauschen F, Blohmer JU, Krappmann K, Schmidt M, Tesch H,
24
Kümmel S, Sinn P, Jackisch C, Dietel M, Reimer T, Untch M, Loibl S.
Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant
Chemotherapy With or Without Carboplatin in Human Epidermal
Growth Factor Receptor 2-Positive and Triple-Negative Primary
Breast Cancers. J Clin Oncol. 2014 Dec 22.
Irving J, Matheson E, Minto L, Blair H, Case M, Halsey C, Swidenbank
I, Ponthan F, Kirschner-Schwabe R, Groeneveld-Krentz S, Hof J,
Allan J, Harrison C, Vormoor J, von Stackelberg A, Eckert C. Ras
pathway mutations are prevalent in relapsed childhood acute
lymphoblastic leukemia and confer sensitivity to MEK inhibition.
Blood. 2014 Nov 27;124(23):3420-30.
Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N,
Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht
J, Bohlander SK, Greif PA, Baldus CD. Mutational spectrum of adult
T-ALL. Oncotarget. 2014 Jul 15.
Relógio A, Thomas P, Medina-Pérez P, Reischl S, Bervoets S, Gloc E,
Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H,
Kramer A, Sers C. Ras-mediated deregulation of the circadian
clock in cancer. PLoS Genet. 2014 May 29;10(5):e1004338.
CC11 für Herz-, Kreislauf- und Gefäßmedizin
Baldenhofer G, Zhang K, Spethmann S, Laule M, Eilers B, Leonhardt
F, Sanad W, Dreger H, Sander M, Grubitzsch H, Baumann G, Stangl
K, Stangl V, Knebel F. Galectin-3 predicts short- and long-term
outcome in patients undergoing transcatheter aortic valve
implantation (TAVI). Int J Cardiol. 2014 Dec 20;177(3):912-7.
Christ T, Grubitzsch H, Claus B, Konertz W. Long-term follow-up after
aortic valve replacement with Edwards Prima Plus stentless
bioprostheses in patients younger than 60 years of age. J Thorac
Cardiovasc Surg. 2014 Jan;147(1):264-9.
Hewing B, Parathath S, Barrett T, Chung WK, Astudillo YM, Hamada
T, Ramkhelawon B, Tallant TC, Yusufishaq MS, Didonato JA, Huang
Y, Buffa J, Berisha SZ, Smith JD, Hazen SL, Fisher EA. Effects
of native and myeloperoxidase-modified apolipoprotein a-I
on reverse cholesterol transport and atherosclerosis in mice.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):779-89.
CC12 für Innere Medizin und Dermatologie
Burmester GR, Kivitz AJ, Kupper H, Arulmani U, Florentinus S, Goss SL,
Rathmann SS, Fleischmann RM. Efficacy and safety of ascending
methotrexate dose in combination with adalimumab: the randomised CONCERTO trial. Ann Rheum Dis. 2014 Feb 18.
Burmester GR, Feist E, Dörner T. Emerging cell and cytokine targets
in rheumatoid arthritis. Nat Rev Rheumatol. 2014 Feb;10(2):77-88.
Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C,
Chang HD, Radbruch A, Zielinski CE. IL-17 and GM-CSF expression
are antagonistically regulated by human T helper cells. Sci Transl
Med. 2014 Jun 18;6(241):241ra80.
Rösel AL, Scheibenbogen C, Schliesser U, Sollwedel A, Hoffmeister B,
Hanitsch L, von Bernuth H, Krüger R, Warnatz K, Volk HD, Thomas S.
Classification of common variable immunodeficiencies using flow
cytometry and a memory B-cell functionality assay. J Allergy Clin
Immunol. 2015 Jan;135(1):198-208.e5.
Tabeling C, Scheer H, Schönrock S, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M. Nucleotide oligomerization domain 1 ligation suppressed
murine allergen-specific T-cell proliferation and airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2014, 50:903-11.
CC13 für Innere Medizin mit Gastroenterologie und
Nephrologie
Bücker R, Schulz E, Günzel D, Bojarski C, Lee IF, John LJ, Wiegand
S, Janßen T, Wieler LH, Dobrindt U, Beutin L, Ewers C, Fromm
M, Siegmund B, Troeger H, Schulzke JD. Alspha-Haemolysin of
Escherichia coli in IBD: a potentiator of inflammatory activity
in the colon. Gut. 2014 Dec;63(12):1893-1901.
Eickmeier I, Seidel D, Grün JR, Derkow K, Lehnardt S, Kühl AA, Hamann
A & Schott E. Influence of CD8 T cell priming in liver and gut on
the enterohepatic circulation. J Hepatol. 2014;60(6):1143-50.
Göhrig A, Detjen KM, Hilfenhaus G, Körner JL, Welzel M, Arsenic
R, Schmuck R, Bahra M, Wu JY, Wiedenmann B, Fischer C. Axon
guidance factor SLIT2 inhibits neural invasion and metastasis
in pancreatic cancer. Cancer Res. 2014 Mar 1;74(5):1529-40.
Sandek A, Swidsinski A, Schroedl W, Watson A, Valentova M., Herrmann
R, Scherbakov N, Cramer L, Rauchhaus M, Grosse-Herrenthey A,
Krueger M, von Haehling S, Doehner W, Anker SD & Bauditz J.
Intestinal blood flow in patients with chronic heart failure: a link
with bacterial growth, gastrointestinal symptoms, and cachexia.
J Am Coll Cardiol. 2014; 64(11):1092-102.
Seidel D, Eickmeier I, Kühl AA, Hamann A, Loddenkemper C & Schott
E. CD8 T cells primed in the gut-associated lymphoid tissue
induce immune-mediated cholangitis in mice. Hepatology.
2014;59(2):601-11.
CC14 für Tumormedizin
Türkmen S, Binder A, Gerlach A, Niehage S, Theodora Melissari
M, Inandiklioglu N, Dörken B, Burmeister T. High prevalence of
immunoglobulin light chain gene aberrations as revealed by FISH
in multiple myeloma and MGUS. Genes Chromosomes Cancer.
2014 Aug;53(8):650-6.
Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Grau M, Hummel
F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J,
Wenzel SS, Lenz P, Schneider M, Küppers R, Scheidereit C, Giefing
M, Siebert R, Rajewsky K, Lenz G, Cockerill PN, Janz M, Dörken B,
Bonifer C and Mathas S. Mapping of transcription factor motifs
in active chromatin identifies IRF5 as key regulator in classical
Hodgkin lymphoma. P. Natl. Acad. Sci. USA. 2014; 111(42):E4513-22.
Listopad J, Kammertoens T, Anders K, Silkenstedt B, Willimsky G,
Schmidt K, Kühl A, Loddenkemper C and Blankenstein Th. Fas
expression by tumor stroma is required for cancer eradication.
Proc. Natl. Acad. Sci. USA 2013; 110: 2276-2281.
Oettle H, Riess H, Stieler JM, Heil G, Schwaner I, Seraphin J, Görner
M, Mölle M, Greten TF, Lakner V, Bischoff S, Sinn M, Dörken B. and
Pelzer U. Second-line oxaliplatin, folinic acid, and fluorouracil
versus folinic acid and fluorouracil alone for gemcitabinerefractory pancreatic cancer: outcomes from the CONKO-003
trial. J. Clin. Oncol. 2014; 32(23):2423-9.
Willimsky G, Schmidt K, Loddenkemper C, Gellermann J and Blankenstein Th. Virus-induced hepatocellular carcinomas cause antigenspecific local tolerance. J. Clin. Invest. 2013; 123: 1032-1043.
CC15 für Neurologie, Neurochirurgie und Psychiatrie
Erk S, Meyer-Lindenberg A, Schmierer P, Mohnke S, Grimm O,
Garbusow M, Haddad L, Poehland L, Mühleisen TW, Wittt SH, Tost
H, Kirsch P, Romanczuk-Seiferth N, Schott B, Cichon S, Nöthen
MM, Rietschel M, Heinz A, Walter H (2014) Hippocampal and
Frontolimbic Function as Intermediate Phenotype for Psychosis:
Evidence from Healthy Relatives and a Common Risk Variant in
CACNA1C. Biological Psychiatry. 2014; (76(6): 466-475.
Fuge P, Aust S, Fan Y, Weigand A, Gärtner M, Feeser M, Bajbouj M,
Grimm S. Interaction of early life stress and corticotropinreleasing hormone receptor gene: effects on working memory.
Biol Psychiatry. 2014 Dec 1;76(11):888-94.
Neumann WJ, Huebl J, Brücke C, Gabriëls L, Bajbouj M, Merkl A,
Schnei-der GH, Nuttin B, Brown P and Kühn AA. Different patterns
of local field potentials from limbic DBS targets in patients with
major depressive and obsessive compulsive disorder. MolPsych
2014 Feb 11.
Haseleu J, Omerbašic D, Frenzel H, Gross M, Lewin GR. Water-Induced
Finger Wrinkles Do Not Affect Touch Acuity or Dexterity in
Handling Wet Objects. PLOS One; January 08, 2014; DOI: 10.1371/
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Klinghammer K, Raguse JD, Plath T, Albers AE, Joehrens K, Zakarneh A,
Brzezicha B, Wulf-Goldenberg A, Keilholz U, Hoffmann J & Fichtner I.
A comprehensively characterized large panel of head and neck
cancer patient-derived xenografts identifies the mTOR inhibitor
everolimus as potential new treatment option. Int J Cancer 2014;1(1):1.
Lin J, Albers AE, Qin J & Kaufmann AM. Prognostic significance
of overexpressed p16INK4a in patients with cervical cancer:
a meta-analysis. PLoS ONE 2014;9(9):e106384.
CC17 für Frauen-, Kinder- und Jugendmedizin mit
Perinatalzentrum und Humangenetik
Blumchen K, Beder A, Beschorner J, Ahrens F, Gruebl A, Hamelmann E,
Hansen G, Heinzmann A, Nemat K, Niggemann B, Wahn U, Beyer K.
Modified oral food challenge used with sensitization biomarkers
provides more real-life clinical thresholds for peanut allergy.
J Allergy Clin Immunol. 2014 Aug;134(2):390-8.
Eifler M, Uecker R, Weisbach H, Bogdanow B, Richter E, König L,
Vetter B, Lenac-Rovis T, Jonjic S, Neitzel H, Hagemeier C, Wiebusch L. PUL21a-Cyclin A2interaction is required to protect
human cytomegalovirus-infected cells from the deleterious
consequences of mitotic entry. PLoS Pathog. 2014 Nov 13;10(10):
e1004514.
Kappel V, Lorenz RC, Streifling M, Renneberg B, Lehmkuhl U, Ströhle A,
Salbach-Andrae H, Beck A. Effect of brain structure and function
on reward anticipation in children and adults with attention
deficit hyperactivity disorder combined subtype. Soc Cogn Affect
Neurosci. 2014 Oct 22.
Schwarz JM, Cooper DN, Schuelke M, Seelow D. MutationTaster2:
mutation prediction for the deep-sequencing age. Nat Methods.
2014;11(4):361-2.
Zemojtel T, Köhler S, Mackenroth L, Jäger M, Hecht J, Krawitz P, GraulNeumann L, Doelken S, Ehmke N, Spielmann M, Oien NC, Schweiger
MR, Krüger U, Frommer G, Fischer B, Kornak U, Flöttmann R,
Ardeshirdavani A, Moreau Y, Lewis SE, Haendel M, Smedley D, Horn
D, Mundlos S, Robinson PN. Effective diagnosis of genetic disease
by computational phenotype analysis of the disease-associated
genome. Sci Transl Med. 2014 Sep 3;6(252):252ra123.
NWFZ Neurowissenschaftliches Forschungszentrum
Herman MA, Ackermann F, Trimbuch T, Rosenmund C. Vesicular
glutamate transporter expression level affects synaptic vesicle
release probability at hippocampal synapses in culture.
J Neurosci. 2014 Aug 27;34(35):11781-91.
Schmitz D, Breustedt J, Gundlfinger A. Retrograde signaling causes
excitement. Neuron. 2014 Feb 19;81(4):717-9.
Watanabe S, Trimbuch T, Camacho-Pérez M, Rost BR, Brokowski B,
Söhl-Kielczynski B, Felies A, Davis MW, Rosenmund C, Jorgensen EM.
Clathrin regenerates synaptic vesicles from endosomes. Nature.
2014 Nov 13;515(7526):228-33.
Whelan R, Watts R, Orr CA, Althoff RR, Artiges E, Banaschewski T,
Barker GJ, Bokde AL, Büchel C, Carvalho FM, Conrod PJ, Flor H,
Fauth-Bühler M, Frouin V, Gallinat J, Gan G, Gowland P, Heinz A,
Ittermann B, Lawrence C, Mann K, Martinot JL, Nees F, Ortiz N,
Paillère-Martinot ML, Paus T, Pausova Z, Rietschel M, Robbins
TW, Smolka MN, Ströhle A, Schumann G, Garavan H; IMAGEN
Consortium. Neuropsychosocial profiles of current and future
adolescent alcohol misusers. Nature. 2014 Aug 14;512(7513):185-9.
MKFZ Molekulares Krebsforschungszentrum
Wingenfeld K, Kuehl LK, Janke K, Hinkelmann K, Dziobek I,
Fleischer J, Otte C, Roepke S. Enhanced emotional empathy
after mineralocorticoid receptor stimulation in women
with borderline personality disorder and healthy women.
Neuropsychopharmacology. 2014 Jul;39(8):1799-804.
Heinig K, Gätjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K,
Niesner RA, Cseresnyes Z, Hauser AE, Lenz P, Hehlgans T, Brink
R, Westermann J, Dörken B, Lipp M, Lenz G, Rehm A, Höpken UE.
Access to follicular dendritic cells is a pivotal step in murine
chronic lymphocytic leukemia B-cell activation and proliferation.
Cancer Discov. 2014 Dec;4(12):1448-65.
CC16 für Audiologie/Phoniatrie, Augen- und HNOHeilkunde
Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B,
Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D,
Naylor T, Pfister E,Kovats S, Kim S, Dietze K, Dörken B, Steidl C,
Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C, Sellers
WR, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F. Pharmacological
and genomic profiling identifies NF-κB-targeted treatment
strategies for mantle cell lymphoma. Nat Med. 2014 Jan;20(1):87-92.
Göktas Ö, Solmaz M, Göktas G, Olze H. Long-term results in obstructive sleep apnea syndrome (OSAS) after laser-assisted uvulopalatoplasty (LAUP). PLoS One. 2014 Jun 30;9(6):e100211.
Dörr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Däbritz JH, Lisec J,
Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfürst B, Walenta S,
Mueller-Klieser W, Gräler M, Hummel M, Keller U, Buck AK, Dörken
B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA. Synthetic
lethal metabolic targeting of cellular senescence in cancer
therapy. Nature. 2013 Sep 19;501(7467):421-5.
25
Rehm A, Gätjen M, Gerlach K, Scholz F, Mensen A, Gloger M, Heinig K,
Lamprecht B, Mathas S, Bégay V, Leutz A, Lipp M, Dörken B, Höpken
UE. Dendritic cell-mediated survival signals in Eμ-Myc B-cell
lymphoma depend on the transcription factor C/EBPβ.
Nat Commun. 2014 Sep 30;5:5057.
Ullrich K, Blumenthal-Barby F, Lamprecht B, Köchert K, Lenze D, Hummel
M, Mathas S, Dörken B, Janz M. The IL-15 cytokine system provides
growth and survival signals in Hodgkin lymphoma and enhances
the inflammatory phenotype of HRS cells. Leukemia. 2014 Dec 9.
RCIS Research Center ImmunoSciences
Liu FD, Kenngott EE, Schröter MF, Kühl A, Jennrich S, Watzlawick R, Hoffmann U, Wolff T, Norley S, Scheffold A, Stumhofer JS, Saris CJ, Schwab
JM, Hunter CA, Debes GF, Hamann A. Timed action of IL-27 protects
from immunopathology while preserving defense in influenza. PLoS
Pathog. 2014 May 8;10(5).
Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Bleienheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M,
Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A. Ubiquitin-like
protein ISG15 in host defense against heart failure in a mouse model
of virus-induced cardiomyopathy. Circulation 2014; 130:1589-1600.
Schumann J, Stanko K, Woertge S, Appelt C, Schumann M, Kühl AA,
Panov I, Schliesser U, Vogel S, Ahrlich S, Vaeth M, Berberich-Siebelt F,
Waisman A, Sawitzki B. The mitochondrial protein TCAIM regulates
activation of T cells and thereby promotes tolerance induction of
allogeneic transplants. Am J Transplant. 2014 Dec;14(12):2723-35.
Syrbe U, Siegmund B. Bone marrow Th17 TNFα cells induce osteoclast
differentiation and link bone destruction to IBD. Gut. 2014 Nov 12.
Weller, K., Groffik, A., Church, M. K., Hawro, T., Krause, K., Metz, M., Martus,
P., Casale, T., Staubach, P., and Maurer, M. Development and validation
of the urticaria control test – a patient reported outcome instrument for assessing urticaria control. J. Allergy Clin. Immunol. 2014.
133; 1365-1372.
CCR Center for Cardiovascular Research
Becker MO, Kill A, Kutsche M, Guenther J, Rose A, Tabeling C, Witzenrath
M, Kühl AA, Heidecke H, Ghofrani HA, Tiede H, Schermuly RT, Nickel
N, Hoeper MM, Lukitsch I, Gollasch M, Kuebler WM, Bock S, Burmester
GR, Dragun D*, Riemekasten G*. Vascular receptor autoantibodies
in pulmonary arterial hypertension associated with systemic
sclerosis. Am J Respir Crit Care Med. 2014 Oct 1;190(7):808-17.
(*shared senior and corresponding authors)
Buschmann I, Hackbusch D, Gatzke N, Dülsner A, Trappiel M, Dagnell M,
Ostman A, Hooft van Huijsduijnen R, Kappert K. Inhibition of protein
tyrosine phosphatases enhances cerebral collateral growth in
rats. J Mol Med (Berl). 2014 Sep;92(9):983-94.
Freise C, Querfeld U. Inhibition of vascular calcification by block of
intermediate conductance calcium-activated potassium channels
with TRAM-34. Pharmacol Res. 2014 Jul;85:6-14.
Kararigas G, Dworatzek E, Petrov G, Summer H, Schulze TM, Baczko I,
Knosalla C, Golz S, Hetzer R, Regitz-Zagrosek V. Sex-dependent regulation of fibrosis and inflammation in human left ventricular remodelling under pressure overload. Eur J Heart Fail. 2014 Nov;16(11):1160-7.
Petrov G, Dworatzek E, Schulze TM, Dandel M, Kararigas G, Mahmoodzadeh
S, Knosalla C, Hetzer R, Regitz-Zagrosek V. Maladaptive remodeling is
associated with impaired survival in women but not in men after aortic
valve replacement. JACC Cardiovasc Imaging. 2014 Nov;7(11):1073-80.
BCRT Berlin-Brandenburg Centrum für Regenerative
Therapien
Abou-El-Enein M, Bauer G, Reinke P, Renner M, Schneider C K. A roadmap toward clinical translation of genetically-modified stem cells
for treatment of HIV. Trends Mol Med. 2014 Nov;20(11):632-42.
Andreas K, Sittinger M, Ringe J. Toward in situ tissue engineering:
chemokine-guided stem cell recruitment. Trends Biotechnol. 2014
Sep;32(9):483-92.
Duda GN, Grainger DW, Frisk ML, Bruckner-Tuderman L, Carr A, Dirnagl U,
Einhäupl KM, Gottschalk S, Gruskin E, Huber C, June CH, Mooney DJ,
Rietschel ET, Schütte G, Seeger W, Stevens MM, Urban R, Veldman A,
Wess G, Volk HD. Changing the mindset in life sciences toward translation: a consensus. Sci Transl Med. 2014 Nov 26;6(264):264cm12.
26
Ehmke N, Caliebe A, Koenig R, Kant SG, Stark Z, Cormier-Daire V,
Wieczorek D, Gillessen-Kaesbach G, Hoff K, Kawalia A, Thiele H,
Altmüller J, Fischer-Zirnsak B, Knaus A, Zhu N, Heinrich V, Huber
C, Harabula I, Spielmann M, Horn D, Kornak U, Hecht J, Krawitz PM,
Nürnberg P, Siebert R, Manzke H, Mundlos S. Homozygous and
compound-heterozygous mutations in TGDS cause Catel-Manzke
syndrome. Am J Hum Genet. 2014 Dec 4;95(6):763-70.
Ringe J, Sittinger M. Regenerative medicine: Selecting the right
biological scaffold for tissue engineering. Nat Rev Rheumatol. 2014
Jul;10(7):388-9.
ECRC Experimental and Clinical Research Center
Grunert M, Dorn C, Schueler M, Dunkel I, Schlesinger J, Mebus S,
Alexi-Meskishvili V, Perrot A, Wassilew K, Timmermann B, Hetzer
R, Berger F, Sperling SR. Rare and private variations in neural
crest, apoptosis and sarcomere genes define the polygenic
background of isolated Tetralogy of Fallot. Hum Mol Genet. 2014
Jun 15;23(12):3115-28.
Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier
C, Izs-vák Z, Spuler S. Human satellite cells have regenerative
capacity and are genetically manipulable. J Clin Invest. 2014 Oct
1;124(10):4257-65.
Mensen A, Jöhrens K, Anagnostopoulos I, Demski S, Oey M, Stroux A,
Hemmati P, Westermann J, Blau O, Wittenbecher F, Movassaghi K,
Szyska M, Thomas S, Dörken B, Scheibenbogen C, Arnold R, Na IK.
Bone marrow T-cell infiltration during acute GVHD is associated
with delayed B-cell recovery and function after HSCT. Blood. 2014
Aug 7;124(6):963-72.
Schleifenbaum J, Kassmann M, Szijártó IA, Hercule HC, Tano JY, Weinert
S, Heidenreich M, Pathan AR, Anistan YM, Alenina N, Rusch NJ, Bader
M, Jentsch TJ, Gollasch M. Stretch-activation of angiotensin II
type 1a receptors contributes to the myogenic response of mouse
mesenteric and renal arteries. Circ Res. 2014 Jul 7;115(2):263-72.
Simaite D, Kofent J, Gong M, Rüschendorf F, Jia S, Arn P, Bentler K,
Ellaway C, Kühnen P, Hoffmann GF, Blau N, Spagnoli FM, Hübner N,
Raile K. Recessive mutations in PCBD1 cause a new type of earlyonset diabetes. Diabetes. 2014 Oct;63(10):3557-64.
* Die Auswahl der Publikationen zeigt das breite Spektrum biomedizinischer Forschung an der Charité. Eine vollständige Liste
aller wissenschaftlichen Publikationen der Charité kann unter
http://www.charite.de/forschung eingesehen werden.
* The selected publications reflect the wide range of biomedical
research done at the Charité. For a comprehensive index of all
scientific publications at the Charité please go to
http://www.charite.de/forschung.