Hans-Martin JÄCK

Transcription

Hans-Martin JÄCK

CURRICULUM VITAE
Hans-Martin JÄCK, Ph.D.
Professor of Immunology
Division of Molecular Immunology
Department of Internal Medicine III
Friedrich-Alexander University Erlangen-Nürnberg
Glückstrasse 6, D-91054 Erlangen, Germany
Telephone:
++49 (9131) 8535912
Telefax:
++49 (9131) 8539343
HJAECK@molmed.uni-erlangen.de
E-mail:
EDUCATION
1988
Ph.D. in Immunology, University of Tübingen, Germany
(summa cum laude)
1984
Diplom (M.Sc. equivalent) in Biochemistry, University of Tübingen,
Germany
1980
Vordiplom (B.Sc. equivalent) in Biochemistry, University of Tübingen,
Germany
PROFESSIONAL APPOINTMENTS AND RESEARCH EXPERIENCE
1997 - present
Division Head
& Professor
1997 - present
Lecturer
1996 -1997
Associate Professor
1990 - 1996
Assistant Professor
1988 - 1990
Postdoctoral Fellow
1984 - 1988
Research Assistant
(Ph.D. student)
Research Assistant
(Ph.D. student)
Research Assistant
(Ph.D. student)
Teaching Assistant
1984 - 1984
1984 - 1984
1979 - 1984
Division of Molecular Immunology
Department of Internal Medicine III
University of Erlangen-Nürnberg, Germany
Loyola University Chicago Medical Center
Department of Microbiology & Immunology
Department of Microbiology & Immunology,
University of California, San Francisco
University of California, San Francisco
Laboratory of Radiobiology
Basel Institute for Immunology, Basel,
Switzerland
Max-Planck Institute, Tübingen,
Germany
Institute of Biochemistry, Tübingen,
Germany
RESEARCH OBJECTIVES (Molecular Biology of B Lymphocytes)
My overall research activities concentrate on molecular aspects of the humoral immune
response. In particular, my lab is interested in signaling pathways and cellular factors
that control early maturation and selection of normal B lymphocytes as well as terminal
differentiation into antibody-secreting plasma cells. In addition, we investigate the
mechanism by which aberrant mRNA, so-called nonsense mRNA, is degraded and
whether this process is important in order to control VDJ recombination and thus the
monospecificity of B lymphocytes.
• Molecular control of B cell development
(Structure, function and signal-transducing capabilities of the immunoglobulin-like
pre-B cell receptor, role of microRNA, Ig class switch)
• Nonsense codon-mediated degradation (NMD) of non-functional Ig mRNA
(mRNA Surveillance)
• Molecular mechanism of plasma cell differentiation and tumorigenesis
• Role of endogenous retroelements in autoimmune diesease
RESEARCH FUNDING
Pending applications for extramural funding
None
Current Extramural Funding
06/13 - 05/17
01/10 – 03/15
German Research Community (DFG)
Transregio TRR130: B cells in immunity and autoimmunity
Project 9: "microRNA-controlled generation and maintenance of
humoral memory"
Positive evaluation, decision May 2014
Principal Investigator: Hans-Martin Jäck
Training Grant GRK1660 (project C4)
“Role of miRNA in plasma cell differentiation”
Previous Funding
10/09 – 06/13
BayImmuNet , Hightec initiative State of Bavaria
“The Mighty Mouse: An in vivo factory to produce human
antibodies”
Principial investigator: Hans-Martin Jäck & Jürgen Wittmann
02/07 – 05/13
Research Group FOR 832/1: Regulators of Humoral Immunity:
(project 2, JA968/5-2)
“Mechanism of pre-B cell receptor mediated selection of the
antibody repertoire”
09/06 – 08/11
Interdisciplinary Center Grant in Clinical Research (IZKF)
“Role of microRNA in B cell maturation and B leukemogenesis”
(Project D5)
Principal Investigators: Hans-Martin Jäck & Jürgen Wittmann
01/09 – 01/11
Individual grant JA 968/6-1
“Current Concepts in Immunology”
(Support for Autumn School in Immunology)
2009-2010
Hiege-Stiftung gegen Hautkrebs, Hamburg
"Evaluation of diagnostic and therapeutic options of microRNAs
(miRNAs) in malignant melanoma"
Principal Investigators: J. Wittmann, H.-M. Jäck and G. Schuler
09/07 – 08/10
Interdisciplinary Center Grant in Clinical Research (IZKF)
“Molecular characterization of signaling complexes in anergic,
autoreactive and normal B lymphocytes“ (Project A7)
Principal Investigators: Hans-Martin Jäck & Dirk Mielenz
05/00 - 04/09
Training Grant GRK592 (project A1)
“Mechanism of pre-B cell receptor mediated signal transduction”
01/02 - 09/07
Individual Research Grant (project JA 968/2)
“Structure and function of the pre-B cell receptor”
06/06 – 05/07
ELAN Fonds (Intramural, FAU Erlangen-Nürnberg)
“Role of the transcriptions factor KLF2 in B cell maturation”
Principal investigators: Wolfgang Schuh & Hans-Martin Jäck
2005 – 2006
ELAN Fonds (Intramural, FAU Erlangen-Nürnberg)
“Role of micro-RNA in early B cell maturation”
Principal investigators: Jürgen Wittmann & Hans-Martin Jäck
2000 - 2004
Alzheimer’s Fund (private contribution)
“Role of aberrant proteins in the pathogenesis of Alzheimer’s
disease”
2000 - 2002
Collaborative Research Project Grant SFB263
“Role of Notch-1 in cell type decisions and apoptotic cell death
processes during development and differentiation of B lymphoid
cells”
Principal Investigators: Hans-Martin Jäck and Birgit Jehn
1999 - 2003
Roche Pharmaceuticals
“In vitro translation using a bioreactor”
1999 - 2006
Collaborative Research Project Grant SFB466
“Molecular mechanisms of pre-B cell receptor-mediated induction
of proliferation and apoptosis in normal B cell precursor cells”
1999 - 2003
Human Frontier Science Project (HFSP)
“Molecular misreading, nonsense transcript stability and
aberrant accumulation in Alzheimer disease”
Principal Investigator(s): E. Hol, Hans-Martin Jäck, H. Dietz,
M. Racchi, J. Verhaagen
1995 - 1998
Tobacco Research Council
“The Role of Surrogate Light Chains During B Cell
Development” Principal Investigator: Hans-Martin Jäck
1995 - 1997
American Cancer Society of America - Research Award
“Biological Function of CD30”
Principal Investigator: Thomas Ellis
Co-Investigator: Hans-Martin Jäck
1995 - 1996
American Cancer Society, Illinois Division
“The Role of Surrogate Light Chains during B Cell
Development”
Principal investigator: Hans-Martin Jäck
1994 - 1998
National Institute of Health (NCI), NIH R29 Grant
“The Role of Endogenous Antigens in B Cell Tumor Formation”
1994 - 1997
American Cancer Society of America
Junior Faculty Research Award
“The Role of Endogenous Antigens in B Cell Tumor Formation”
1994 - 1997
Allergen Inc., San Francisco (contract)
“Generation of a mouse/human chimeric anti-poison ivy
antibody”
1994 - 1997
American Cancer Society
“Endogenous Antigens in B Cell Tumor Formation”
Principal investigator: Hans-Martin Jäck
(Due to scientific overlap with NIH R29 grant below, I did not
accept this research award)
1992 - 1995
Schweppe Career Development Award
1991 - 1994
National Cancer Institute, NIH R01 Grant
“Biology and Treatment of AIDS Lymphomas”
Principal Investigator: Richard Fisher
Co-Investigator: Hans-Martin Jäck
1992 - 1993
Loyola Cancer Research Institute, Potts Foundation
(intramural)
"Mechanisms of Immunoglobulin mRNA Degradation"
1992 - 1993
American Cancer Society, Illinois Division
"The Role of Endogenous Antigens in B Cell Tumor Formation"
1990 - 1991
Loyola Cancer Research Institute, Potts Foundation
(intramural)
"The Role of Endogenous Antigens in B Cell Tumor Formation"
PROFESSIONAL ACTIVITIES
• Member of Editorial Boards, Study Sections and Review Panels
2011-present
2010 - present
Member, advisory board (Kuratorium), Fraunhofer-Instituts für
Zelltherapie und Immunologie (IZI), Leipzig
Member, Editorial Board, Frontiers in Molecular Antigen Presenting
Cell Biology
Review Editor, Frontiers in B Cell Biology
2009 - present
Member, Editorial Board, European J. of Immunology
2004 - present
2005
Member, Editorial Board, Current Immunology Reviews
Guest Editor, Seminars in Immunology
2001 - 2005
Associate Editor, Journal of Immunology
2002
Member, Evaluation Committee for the Heinrich-Pette Institute,
Leibniz Society Germany
2011- present
1999 - present
Member, Committee on Animal Research, State of Bavaria,
District, Lower Franconia, Germany
1996 - 1998
Member, Medical Advisory Board
Leukemia Research Foundation Chicago
1996 - 1999
Member, Adhoc study section
National Cancer Institute of Canada
1996
Member, Adhoc Immunology and Virology NIH study section
• Extramural Activities and Appointments
2013-present
President, German Society of Immunology (DGfI)
Presidency starts January 2013)
2008 - present
Leading coordinator, Immunology Autumn School
German Society of Immunology (DGfI)
2007 -present
Member, committee on education in immunology
2006 - present
Speaker of 11 research study groups of the
2006 - 2010
Associate council member, German Society of Immunology
2004 - present
Speaker, research study group B Lymphocytes,
German Society of Immunology
http://www.molim.uni-erlangen.de/akb/
2000 - present
Council member, Biochemical Society Tübingen (MoBBEL),
Germany
• University Programs and Committees (University of Erlangen, Germany)
2013 - present
Member, Coordination committee
DFG Transregio TRR130 initiative
2010 - present
Director, DFG Doctoral Training Grant GRK1660
Key signals of adaptive immunity
http://www.lymphozyten.de/
2006 - present
Co-Director, DFG research group FOR832
Regulators of humoral immunity
http://www.for832.uni-erlangen.de/kontakte.html
2004 - present
Member, Committee on Research and postgraduate education,
Medical School University of Erlangen-Nürnberg
2002 - present
Director, Immunology module
Graduate programs in Molecular Medicine and Biology
2000 - 2009
Director, DFG Doctoral Training Grant GRK592 Lymphocytes
http://www.lymphozyten.de/
1998 - 2002
Member, Intramural Research Grant Committee (ELAN)
Medical School
1997 - 2002
Member, Committee on Research, Medical School
• Departmental Committees (Loyola University Chicago, Medical School)
1990 - 1997
Member, Graduate Admission Committee
Graduate Program in Microbiology and Immunology
1992
Chair, Committee for the Evaluation of Graduate Affairs
1995
Chair, Faculty Search Committee
1996 - 1997
Member, Equipment Committee
1996 - 1997
Member, Committee for Public Education
• University Programs and Committees (Loyola University Chicago, Medical School)
1990 - 1997
Member, Interdepartmental Ph.D. Program in Molecular Biology
1995 - 1997
Member, Curriculum Committee, Molecular Biology program
1990 - 1997
Member, Cancer Research Institute
(Director: Dr. Richard Fisher)
1991 - 1994
Member, AIDS/Lymphoma Committee, Loyola University
(Chair: Dr. Richard Fisher)
1990 - 1992
Member of the Biomolecular Facility Committee, Loyola
University (Chair: Dr. Robinson)
1993 - 1997
Member, Ad hoc committee, Reconstruction of Loyola's Animal
Facility (Chair: Dr. G. Engelmann)
1992 - 1994
Member, Retreat Committee, Molecular Biology Program
Loyola University
1995 - 1997
Member, Curriculum Committee, Molecular Biology Program,
Loyola University
• Invited Reviews
Manuscripts
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EMBO J
J. Exp. Med
Immunobiology
Molecular and Cellular Biology
Experimental Cell Research
Proceedings of the National Academy of Sciences U.S.A.
(PNAS)
Journal of Immunology (Associate editor, 2000-2005)
International Immunology
Cancer Research
Journal of Cranial-Maxillofacial Surgery
Immunobiology
European Journal of Immunology
(Member of the Editorial Board since 2007)
Research Grant
Applications
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Book reviews
•
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National Institute of Health (NIH, U.S.A.)
German Research Community (DFG, Germany)
European Research Council (ERC)
National Cancer Institute (NCI) of Canada
Welcome Trust
Helmholtz Foundation, Germany
Ministry of Research, State of Thuringia, Germany
Ministry of Research, State of Tirol, Austria
Leukemia Research Foundation (U.S.A.)
Wilhelm-Sander-Foundation (Germany)
Fonds zur Förderung der wissenschaftlichen Forschung
(FWF, Austria)
Charite Intramural Funding, Berlin, Germany
Jubiläumsfonds, Oesterreichische Nationalbank (Austria)
Minerva Foundation, Israel/Germany
Human Science Frontier Project (HSFP)
The Department of Veteran’s Affairs (U.S.A.)
”Bispecific Antibodies” by Michael W. Fanger, R.G. Landes
Company
”Molecular Immunology”, edited by B.D. Hames and D.M.
Glover, Doody Publishing
• Consulting
2004 - 2009
1998 - 2005
1992 - 1997
Picobella, Burlingame, California, U.S.A.
Roche Molecular Diagnostics, Penzberg, Germany
Allergen Inc., San Francisco, CA, U.S.A.
1994 - 1996
Abbott Laboratories, Chicago, IL, U.S.A.
• Membership in Professional Societies
Society of Biological Chemistry (GBCH), Germany
Signal Transduction Society, Germany
Kunckel Society, Rockefeller University, USA
German Society of Immunology (DGfI), Germany
(Associate member of the council since 2005)
Biochemical Society Tübingen (MoBBEL), Germany
(member of the council since 2000)
American Association for the Advancement of Science (AAAS), U.S.A.
Illinois Society of Medical Research, U.S.A.
American Society of Microbiology, U.S.A.
American Association of Immunologists (AAI), U.S.A.
Chicago Association of Immunologists (CAI), U.S.A.
TEACHING
• Graduate Courses (Loyola University)
MICRO 413:
MICRO 420:
MBIO 417:
MICRO 411:
MICRO 414:
MICRO 431:
MICRO 471:
MICRO 443:
Basic Concepts of Immunology
Course Director: Jäck
Methods in Molecular Biology
Course directors: Jäck and Gallagher
Introduction into Molecular Biology (Course Director: Dr. M.
Kelley) Lectures: - Control of mRNA turnover
Introduction into Microbiology (Course Director: Dr. W. Yotis)
Lectures: - Protein synthesis in prokaryotes
General Virology (Course Director: Dr. T. Gallagher)
Lectures: Viral pathogens, virokines, and immunity against viruses
Molecular Virology (Course Director: Dr. S. Baker)
Lectures: Biology and Immunology of HIV
Molecular Microbial Genetics (Course Director: Dr. Alan Wolfe)
Lecture: Somatic Mutation in Mammalian Cells
Molecular Biology of B Cell Differentiation
(Course Directors : Knight & Jäck)
• Graduate Courses (University of Erlangen, Germany)
MOLIM-S1:
MOLIM-S2:
MOLIM-P1:
MOLIM-P2:
MOLIM-S3:
MEDBIO-S2:
Concepts of Immunology (Course Director: Jäck, Beuscher)
Aspects of humoral immunity (Course Director: Jäck)
Laboratory course in Molecular Immunology (4 weeks)
(Course Director: Jäck)
Advanced laboratory course in Molecular Immunology (6 weeks)
(Course Director: Jäck)
Special topics in humoral immunity (Course Directors: Jäck)
Seminar in Biochemistry for medical students
(Course Director: Becker)
SUPERVISION OF STUDENTS AND POSTDOCTORAL FELLOWS
Erlangen
7 Postdoctoral fellows
20 PhD students
3 MD students
30 MS students
20 BS students
Chicago
4 Postdoctoral fellows
6 PhD student
1 MD/PhD student
5 Undergraduate students
I am currently a member of 8 PhD advisory committees in the graduate programs of
Molecular Medicine and Cellular Biology in Erlangen
HONORS & AWARDS
2013-2014
since 2010
1994
1992 - 1994
1992
1989
1989
1988
1984
President, German Society for Immunology
Member, Henry-Kunkel Society, Rockefeller University New York
Junior Faculty Research AwardAmerican Cancer Society, U.S.A.
Member, Scientist-Educator Team (SET) Program, sponsored by the
National Science Foundation and the American Society of
Microbiology
Schweppe Career Development Award
MoBBEL Prize, Biochemical Society Tübingen, Germany
(Outstanding Ph.D. thesis in Biochemistry)
Günther-Weitzel Lecture
3rd International Autumn Meeting of the Biochemical Society
Summa cum laude (Ph.D.)
Department of Biology, University of Tübingen, Germany
Max-Planck Fellowship, Max-Planck Society, Germany
INVITED SPEAKER
2014
Symposium B cells, German Society of Immunology, Bonn
2014
Guest Symposium , American Association of Immunologists, Pittsburgh
2014
German-Argentinian Workshop
2014
Workshop - miRNA in immunity Zürich, Switzerland
2013
Study Group B Cells, Schluchsee, Germany
2013
Spring School of Immunology, Ettal, Germany
2013
European Workshop on Rheumatic Disease, Prague
2012
Department of Immunology, University of Basel
2012
International Symposium on Adaptive Humoral Immunity, Erlangen
2012
Department of Biochemistry, University of Tübingen
2012
Hofmann La Roche, Penzberg, Germany
2012
1st German-Italien Workshop on miRNA and Immunity, Lake Garda
(organizer)
2012
2012
Department of Chemical Pharmacy, University of Frankfurt
Annual European Congress of Rheumatology
2012
Kunkel Society Annual Meeting, Berlin, Germany
2012
Midwestern Immunology Conference, Birmingham, Alabama
2012
Department of Rheumatology, University of Freiburg, Germany
2012
Guest symposium, 99th Annual Meeting, American Association of
Immunologist, Boston, USA
2012
Department of Veternary Medicine, Vienna
2012
Department of Rheumatology, University of Freiburg
2012
International IZKF Symposium, Kloster Banz
2012
B Cell Forum, Arbeitskreis B-Zelle, Kloster Banz
2012
Spring School of Immunology, Ettal
2012
1. Gradute Student Symposium, University of Turku, Finland
2012
Division of Experimental Immunology, University of Amsterdam
2011
Study Group B Cells, Bad Sooden
2011
Department of Immunology, LMU München, Germany
2010
Department of Immunology, University of Tübingen
2010
Graduiertenkolleg-Symposium, Essen
2010
8th German-Japanese Symposium, Cuxhaven, Germany
2010
1st German-Chinese Symposium, Burg Wanzleben, Magdeburg, Germany
2010
Annual Meeting DGfI Study Group 'B cells', Dresden, Germany
2010
Graduiertenkolleg - Symposium, Hamburg, Germany
2010
Department of Clinical Immunology, Necker Hosptital, Paris, France
2010
2010
Kunkel Society Annual Meeting, The Rockefeller University, New York, USA
Advances in Targeted Therapies, Mandelieu, France
2010
30th European Workshop of Rheumatology, EWRR, Bamberg, Germany
2010
Babraham Research Institute, Cambridge, England
2010
Biotechnikum, Erlangen, Germany
2010
AR:O.S.A. V Expert Workshop: Current Rheumatology, Berlin, Germany
2009
Department of Surgery University of Michigan, Ann Arbor, USA
2009
Department of Immunology, Loyola University Chicago, USA
2009
Department of Immunology, University of Jena, Germany
2008
Medical University of Tokio, Japan
2008
German-Japanese Immunology meeting, Fukuoka, Japan
2008
Department of Cell Biology, University of Bern, Switzerland
2008
5th B Cell Forum, Eibsee, Germany
2008
Immunology Spring School 2008 Cloister Ettal, Bavaria
2008
Department of Immunology, University of Göttingen, Germany
2007
Department of Surgery, University of Minnesota, Rochester, USA
2007
Roche Forum: The B Cell Interdisciplinary, Castle Wernberg-Köblitz,
Germany
2007
Immunology Spring School 2007, Cloister Ettal, Bavaria
2007
4th B Cell Forum, Banz, Germany
2007
Max-Planck-Institute for Immunobiology, Freiburg, Germany
2006
IZKF Symposium on Tissue and Inflammation, Bamberg, Germany
2006
ESF-EMBO Symposium on B Cells Cross the Divide: From In Silico to the
Whole Person, Sant Feliu de Guixols, Spain
2006
University of Marburg, Department of Microbiology, Germany
2006
University of Würzburg, Department of Immunology, Germany
2005
3rd B Cell Forum, Bad Breisig, Germany
2004
University of Marseille, Department of Pathology, France
2004
Laudatio, 150th Birthday of Emil von Behring, Emil-von-Behring High
School, Erlangen
2004
2st German B Cell Forum, Potsdam, Germany
2003
1st German B Cell Forum, Titisee, Germany
2003
Autumn Meeting of the Signal Transduction Society (STS) Weimar
2003
Symposium on B Lymphopoiesis II, 70th Birthday of Max Cooper
Birmingham, Alabama, USA
2003
Annual Congress of the American Association of Nephrologists, San Diego,
USA
2002
University of Essen, Department of Cell Biology, Germany
2001
Max-Planck-Institute, Martinsried, Division of Neuroimmunology
2001
Württemberger Rheumatology Days, University of Tübingen, Germany
1999
University of Freiburg, Division of Rheumatology, Germany
1999
2. Signaltransduction Meeting, Signal Transduction Society, Berlin
1998
University of München, Institute of Immunology, Germany
1998
EMBO Symposia: Signaling in B cell development, Sweden
1997
10th International Autumn Meeting of MoBBEL, Tübingen, Germany
1997
Minisymposium: B Cell Development, FASEB, San Francisco, USA
1997
Chicago Association of Immunologists, Chicago, USA
1996
University of Toronto, Department of Immunology, Canada
1996
University of Illinois at Chicago, Department of Microbiology, USA
1996
University of Erlangen-Nürnberg, Department of Medicine, Germany
1996
Wabash College, Indiana, USA
1996
Rush University Medical School, Department of Immunology, USA
1995
University of Heidelberg, Department of Biochemistry, Germany
1995
University of Erlangen, Department of Internal Medicine, Germany
1995
University of Health Sciences, Chicago Medical School, Chicago, USA
1995
Illinois Institute of Technology, Department of Biology, Chicago, USA
1994
1994
University of Erlangen, Institute of Rheumatology, Germany
1993
University of Health Sciences, Chicago Medical School, Chicago, USA
1993
American Heart Transplantation Meeting, Atlanta, USA (Antibodies as a tool
to prevent graft rejections)
1993
1993
3rd European Congress on Lupus Erythrematodes, Erlangen, Germany
1993
First Symposium in Molecular Medicine, Loyola University, USA
1993
Northeastern Illinois University, Department of Biology, Chicago, USA
1993
University of Erlangen, Department of Immunology, Germany
1992
Symposium ”30 Year: Ph.D. Program in Biochemistry”, University of
Tübingen, Germany
1991
6th International Autumn Meeting of MoBBEL, Perugia, Italy.
1990
5th International Autumn Meeting of MoBBEL Prague, C.S.F.R.
1990
University of Erlangen, Department of Immunology, Germany
1990
University of South Carolina, Columbia, U.S.A.
1990
University of Illinois, Chicago, U.S.A.
1990
Iowa State University, Ames, U.S.A.
1990
Northwestern University Chicago, U.S.A.
1990
University of Toronto, Canada
1989
2nd UCSF/UCB Immunology Conference Asilomar, U.S.A.
1989
4th International Autumn Meeting of MoBBEL Thannheim, Austria
1989
University of Freiburg, Fed. Rep. of Germany
1989
University of München, Fed. Rep. of Germany
1989
Basel Institute of Immunology, Basel, Switzerland
1989
University of Tübingen, Fed. Rep. of Germany
1989
University of Erlangen, Fed. Rep. of Germany
1989
Schering Inc., Berlin, Fed. Rep. of Germany
PEER-REVIEWED PUBLICATIONS
Professor of Immunology
1. Winkelmann R, Sandrock L, Kirberg J, Jäck HM, Schuh W. (2014). KLF2-a negative
regulator of pre-B cell clonal expansion and B cell activation. PLoS One. May
29;9(5):e97953.
2. Gabler J, Wittmann J, Porstner M, Renz H, Jäck HM, Abram M, Zemlin M. (2013).
Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell
survival. Eur J Immunol. 43(11):3028-37.
3.
Brachs S, Lang C, Buslei R, Purohit P, Fürnrohr B, Kalbacher H, Jäck HM, Mielenz D.
(2013). Monoclonal Antibodies to Discriminate the EF Hand Containing Calcium
Binding Adaptor Proteins EFhd1 and EFhd2. Monoclon Antib Immunodiagn
Immunother. 32(4):237-45.
4.
Metzner, M., Jäck, H.-M. and Wabl, M. (2012). LINE-1 Retroelements Complexed and
Inhibited by Activation-Induced Cytidine Deaminase PloS ONE 7(11):e49358.
5.
Newrzela S. Al-Ghaili N, Heinrich, T, Petkova M., Hartmann S, B Rengstl B, Kumar A,
Jäck HM, Gerdes S, Roeder I, Hansmann ML, and von Laer D (2012). T-cell receptor
diversity prevents T-cell lymphoma development. Leukemia (12):2499-507.
6.
Preussner, M.; Schreiner, S.; Hung, L-.H.; Porstner, M.; Jäck, H.-M.; Benes, V.;
Bindereif, A. (2012). HnRNP L and L-like cooperate in multiple-exon regulation of CD45
alternative splicing. Nucl Acids Res 40(12):5666-78 .
7.
Thiele S, Wittmann J, Jäck H-M, Pahl A (2012). miR-9 enhances IL-2 production in
activated human CD4+ T cells by repressing Blimp-1. Eur J Immunol 42(8):2100-8.
8.
Buettner M., Lang A, Tudor CS, Meyer B, Cruchley A. Barros M, Farrell P, Jäck H-M,
Schuh W, Niedobitek G (2012). Lytic EBV infection in epithelial cells but not in B
lymphocytes is dependent on Blimp1. J Gen Virol 93(Pt 5):1059-64.
9.
Wittmann J, Jäck H-M, Mashreghi MF. [MicroRNAs in B-cells and T-cells as regulators
of inflammation]. (2011). Z Rheumatol Aug;70(6):507-10. German.
10. Dedman AM, Majeed Y, Tumova S, Zeng F, Kumar B, Munsch C, Bateson AN,
Wittmann J, Jäck H-M, Porter KE, Beech DJ. (2011). TRPC1 transcript variants,
inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle
cells. BMC Mol Biol. 12;12:30.
11. Lutz J, Müller W, Raman C, Jäck H-M (2011). Immunoglobulin Heavy Chain mRNA
Controls VDJ Rearrangement. Proc Natl Acad Sci USA 108(26):10644-9.
12. Vettermann, C, Castor D, Mekker A, Gerrits B, Karas M and Jäck H-M (2011).
Proteome profiling suggests a pro-inflammatory role for plasma cells through release of
high-mobility group box 1 protein. Proteomics (7):1228-37.
13. Wittmann J & Jäck H-M (2011). microRNAs in rheumatoid arthritis: midget RNAs with
a giant impact. Ann Rheum Dis. 2011; 70(Suppl_1): p. i92-96i
14. Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, Reth M, Kahn
ML, Schuh W, Jäck HM (2011). B cell homeostasis and plasma cell homing controlled
by Kruppel-like factor 2. Proc Natl Acad Sci U S A. Dec 27. [Epub ahead of print].
15. Lang VR, Mielenz D, Neubert K, Böhm C, Schett G, Jäck HM, Voll RE, Meister S.
(2010). The early marginal zone B cell-initiated T-independent type 2 response resiststhe
proteasome inhibitor bortezomib. J Immunol. 185(9):5637-47. Epub2010 Oct 4.
16. Wittmann J, Jäck HM (2010). Serum microRNAs as powerful cancer biomarkers.
Biochim Biophys Acta. 1806(2):200-7. Epub 2010 Jul 13.
17. Wittmann J, Jäck HM. New surprises from the deep--the family of small regulatory
RNAs increases (2010). ScientificWorldJournal. 10:1239-43. Review.
18. Danke C, Grünz X, Wittmann J, Schmidt A, Agha-Mohammadi S, Kutsch O, Jäck HM,
Hillen W, Berens C (2010). Adjusting transgene expression levels in lymphocytes with
aset of inducible promoters. J Gene Med. 12(6):501-15.
19. Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm
L,Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog
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30. Wittmann, J. and Jäck, H.-M. (2008). Chapter 13. Identifying substrates of mRNA decay
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31. Schuh, W., Meister, S., Herrmann, K., Bradl, H., and Jäck, H.-M. (2008). Transcriptome
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42. Wittmann, J. & Jäck, H.-M. (2006). UPF2 silencing identifies physiologic substrates of
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43. Jäck, H.-M. (2006). Editorial: The ins and outs of early B cell development. Sem.
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44. Vettermann, C., Herrmann, K. & H.-M. Jäck (2006). Powered by pairing:
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47. Mielenz, D., Vettermann, C., Lang, C, Hampel, M, Karas, M., Jäck, H.-M. (2005). Lipid
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50. Jäck, H.-M., W. Schuh, S. Meister,E. Roth (2004). The Authors Respond: Signaling and
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53. Mielenz, D., Ruschel, A., Vettermann, C., and Jäck, H.-M. (2003). Immunoglobulin
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64. Kline, G.H., Hartwell, L., Beck-Engeser, G.B., Keyna, U., Zaharevitz, S., Klinman, N.R.,
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65. Powell, I.F., Li, T., Jäck, H.-M., Ellis, T.M. (1998). Construction and expression of a
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66. Siemasko, K, Chong, A, Jäck, H.-M., Gong, H., Williams, J.W., and Finnegan, A.
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67. Weiss, A., Waiser, J., Serfling, E., Nebl, G., Samstag, Y, Jäck, H.-M., Gessner, A.,
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68. Rowley, A.H., Eckerly, C.A., Knight, K., Jäck, H.-M., Shulman, S.T., and Baker, S.-C.
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69. Applequist, S.E., Selg, M, Raman, C, and Jäck, H.-M. (1997). Cloning and
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70. Napolitano, E.W., Villar, H.O, Kauvar, L.M., Higgins, D.L., Roberts, D., Mandac, J.,
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71. Alzona, M, Jäck H.-M., Simms P. E., and T. M. Ellis (1996), Interleukin-12 Activates
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73. Applequist, S.E., Keyna, U., Calvin, M., Raman, C., Beck-Engeser, G., and Jäck, H.-M.
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74. Bornemann, K., Brewer, J., Beck-Engeser, G., Corley, R., Haas, I.G. and Jäck, H.-M.
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75. Keyna, U., Beck-Engeser, G. Applequist, S.E., and Jäck, H.-M. (1995). Immunoglobulin
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76. Alzona, M, Jäck, H.-M., Fisher, R., and Ellis, T. (1995). IL-12 activates IFN-
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79. Jäck, H.-M., Sloan, B., Grisham, G., Reason, D., and Wabl, M. (1993). An
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80. Jäck, H.-M., Beck-Engeser, G., Lee, G., and Wabl., M. (1992). Tumorigenesis mediated
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81. Jäck, H.-M., Beck-Engeser, G., Sloan, B., Li, M., Wofsy, D., and Wabl, M. (1992). A
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87. Wabl, M, Jäck, H.-M., von Borstel, R. C. and Steinberg, C.M. (1989). Scope of action of
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96. Jäck, H.-M., Koch, R., Krämer, H., Deger, A., Rapp, R., Müller, G., & Weber,U. (1984).
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Endokrin. 5, 115.

Hans-Martin JÄCK

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