Synthe sche Biologie: Ethik und Forschungsförderung in Europa

Synthe sche Biologie: Ethik und Forschungsförderung in Europa

!"#$%&'()%&*+,-.-/,&0*1$%,2
3#4*5-6()%3#/(7864&63#/*,#
136-9:
!"#$%&!'()*"+,-./0%#'
!"#$%&'()*+,-./'01,'21,'34567/'(,89::1';",&&1#
<,=&">1.9'?=#$,@A';#=%B
;<=>?*@,&#
=A*B3#,*C>=>
?"&',&.'&9@.*1C&)*1'<,=:=A,1D
E F,1:1'51G@,C=@1@/'"81#'H1@.#":',&.'-,1
E I@J1@-%@A',@A1@,1%#&KJ,&&1@&)*"L:,)*1#
2#,@H,B,1@',@'-1#'<,=:=A,1M
E N1#&.1::%@A'O=@'@1%1@'%@-'%@@".P#:,)*1@
8,=:=A,&)*1@'(9&.1+1@M
(9@.*1C&)*1'<,=:=A,1
Q=#&)*%@A&"$CO,.R.'(<
4;S!
!==#1T&)*1';1&1.H'-1#'5UI'(9@.*1&1
Carlson 2009. Nat Biotech.
F1@.1#V'A:=8":1&'!1-,1@,@.1#1&&1
W!"#$%&%'(&%"&%)*%+#"#$,#"#$%
-&%+./%01,2"3(44.++.(0"'(&
#$%"5#*/6"('"7.(%#$.8,2".++*%+
*0/%&#,9%:",+"#$%.&";&+#
(&/%&"('"<*+.0%++:","+#*/6"('
#$.+"+8.%01;8"4.2%+#(0%MMMX
<"#")$'Y8"+"'=@'(<
!"9'Z[.*/'Z[\[
]('^=@A#1&&'I@*_#%@A'H%
U%.H1@`a,&,$1@'-1#'(<
S%#=B1"@';#=%B'=@'S.*,)&',@
(),1@)1'"@-'U1J'b1)*@=:=A,1&
I&,:=+"#'^=@>1#1@H'\cde
]('2#=f1$.1'H%'(<KS0(I'b*1+1@
Synthetic Aesthetics
Science/Society understanding JCVI
Ethics non-physical harm: Hastings
Synbioproject: WWCIS
Web portal dual use/biosecurity
OECD-NAS-RS
Symposium
SynbERC: Thrust IV - Human Practices
JCVI-MIT-CSIS
Risks and benefits of synthetic genomics
Several biosecurity related activities, e.g. NSABB, guidelines
SB 1.0
2004
SB 2.0
2005
2006
SB 3.0
2007
SB 4.0
2008
2009
2010 and beyond
S%#=BR,&)*1'2#=f1$.1'H%'(<KS0(I'b*1+1@
ESF: SYNMOD (WP5)
CISYNBIO: cinema and SB
Synth-Ethics: general ELSI
FUGE: ethics, STS, complexity
SYBHEL: ethics - human health
Biosafety Austria/EU - China
BBSRC Networks incl. ELSA
TARPOL: WP1 + WP5
COSY Communicating SB
TESSY
Towards a SB Roadmap
SYNBIOSAFE
Safety and ethical aspects of SB
PACE: incl. ethical considerations concerning artificial cells
SB 1.0
2004
SB 2.0
2005
2006
SB 3.0
2007
SB 4.0
2008
2009
2010 and beyond
g'b*1+1@>1:-1#
1) System assembly and molecular and
cellular complexity in a context of
Darwinian evolution
2) Computational design tools
3) The biosystems design laboratory
4) The social context
S(Q'S]aY(hU<4Y
Zg'2#=B=&":&'(.%>1'\
\i'1,@A1:"-1@',@'(.%>1'Z
c'B=&,CO'81J1#.1.
e'2#=f1$.1'J1#-1@'A1>_#-1#.
Kj')"'k['4@-,O,-%":'2#=f1).&/'-"O=@'@%#'\'S0(I
1$%,2*3#4*5-6()%3#/(7864&63#/
,#*136-9:
E I%&J"*:'#1:1O"@.1#`,@.1#1&&"@.1#'0R@-1#
E ]^/'5S/'Qa/'U0/'6N/'Ib
E 4@.1#O,1J&'+,.'@"C=@":1@
Q=#&)*%@A&>_#-1#1#@'3f1J1,:&'Z'B#='0"@-7
Q=#&)*%@A&"$CO,.R.1@',@'S%#=B"
AT-1
AT-2
CH-1
DE-1
DE-1
FR-1
FR-2
NL-1
NL-2
UK-1
UK-2
(<V'S,@1'51G@,C=@&>#"A1
biocircuits using standard biological parts
+
+
+
+
+
+
+
+
?
+
+
biocircuits without standard biological parts?
+
+
+
+
+
+
+
+
?
+
+
engineering cells to produce fine chemicals
+
-
+
+
+
+
+
+
+
+
+
creating artificial life
-
+
+
-
-
+
+
-
?
+
+
computer software for biocircuit design
-
+
+
+
+
+
+
+
-
+
-
artificial ecosystems
-
-
+
?
?
+
+
-
-
+
-
enlarged genetic alphabet
+
+
+
+
+
+
+
+
+
+
+
DNA with chemically different backbone
+
+
+
+
+
+
+
+
+
+
+
minimal genome
-
-
+
+
+
+
+
+
?
+
+
understanding the origin of life
+
-
-
+
+
+
+
-
+
+
+
S#A18@,&&1'Q_#-1#&,.%"C=@
SB
community
ELSA
community
Austria
–
+
–
+
+
France
+
+/–
–
–
–
Germany
+
+
+
+
–
Netherlands
+
+
+
+/–
+
Switzerland
+
+/–
+
+/–
+
UK
+
+
+
+
+
Land
SB
Förderu n g
ELSA
Förderu n g
Link Förderung
/ community
lV'NQ0(']#&B#%@A/'(":H8%#A
2#=.1,@1'ZM[
I+9:"&1`^".":"&1'+,.'@,)*.K$"@=@,&)*1@'I+,@=&R%#1@
Ethionine
Catalase
Bacillus subtilis 1A55
Methionine
Norleucine
m%A1@-',@@=O"COV
<%@-1&+,@,&.1#'!,n1#:1*@1#'H1,)*@1.1'-,1
81&.1@'()*P:1#Kb1"+&'"%&
6,@1+"'"@-'(9@.*1C)'<,=:=A9
Orthosome Text
www.cisynbio.com
Bio:fiction bringt alle zusammen:
Filmemacher
Kunst- & Kulturschaffende
Civil Journalists
Presse und Medien
Wirtschaft, Biotechunternehmen
Wissenschafter
O,-1=
Danke !