Physical Activity 2016: Progress and Challenges
Transcription
Physical Activity 2016: Progress and Challenges
16tl0662 Series RMH THELANCET-D-16-00662R2 S0140-6736(16)30581-5 Embargo: July 27, 2016—23:30 (BST) This version saved: 16:33, 19-Jul-16 Physical Activity 2016: Progress and Challenges Progress in physical activity over the Olympic quadrennium James F Sallis, Fiona Bull, Regina Guthold, Gregory W Heath, Shigeru Inoue, Paul Kelly, Adewale L Oyeyemi, Lilian G Perez, Justin Richards, Pedro C Hallal, for the Lancet Physical Activity Series 2 Executive Committee* On the eve of the 2012 summer Olympic Games, the first Lancet Series on physical activity established that physical inactivity was a global pandemic, and global public health action was urgently needed. The present paper summarises progress on the topics covered in the first Series. In the past 4 years, more countries have been monitoring the prevalence of physical inactivity, although evidence of any improvements in prevalence is still scarce. According to emerging evidence on brain health, physical inactivity accounts for about 3·8% of cases of dementia worldwide. An increase in research on the correlates of physical activity in low-income and middle-income countries (LMICs) is providing a better evidence base for development of context-relevant interventions. A finding specific to LMICs was that physical inactivity was higher in urban (vs rural) residents, which is a cause for concern because of the global trends toward urbanisation. A small but increasing number of intervention studies from LMICs provide initial evidence that community-based interventions can be effective. Although about 80% of countries reported having national physical activity policies or plans, such policies were operational in only about 56% of countries. There are important barriers to policy implementation that must be overcome before progress in increasing physical activity can be expected. Despite signs of progress, efforts to improve physical activity surveillance, research, capacity for intervention, and policy implementation are needed, especially among LMICs. Published Online July 27, 2016 http://dx.doi.org/10.1016/ S0140-6736(16)30581-5 Introduction See Online/Articles http://dx.doi.org/10.1016/ S0140-6736(16)30370-1, and http://dx.doi.org/10.1016/ S0140-6736(16)30383-X Every 4 years, the summer Olympic Games divert much of the world’s attention from the conflicts and tragedy that regularly dominate the news. The sight of talented athletes pushing their bodies to the limits inspires some viewers to greater achievements in sport and life. Health professionals hope that 2 weeks of exposure to images and stories of athletics will lead viewers to make increased efforts to be physically active in their own lives, even if at a much lower level than the athletes. Although no evidence has shown that the Olympics impact physical activity in the host country or elsewhere,1 the Olympic Games aim a powerful media spotlight on human movement. As the London Olympic Games were poised to open in July, 2012, the first Lancet Series on physical activity identified physical inactivity as a global pandemic and urgent public health priority. A wide variety of interventions have been shown to be effective, but they have not been widely implemented, so public health agencies were called upon to collaborate with sectors such as transportation, health care, and sport to mount a stronger response to this health challenge.2 The 2012 Series was widely covered in media worldwide, and the Series papers have been heavily cited. With the imminent inauguration of the 2016 summer Olympic Games in Rio de Janeiro, we ask how much progress has been made during the Olympic quadrennium in research, practice, and policy regarding physical activity. This first paper in this second Lancet physical activity Series provides a progress report on the topics covered in the 2012 Series. Different approaches to identifying progress were taken that were deemed appropriate to each topic. The progress reports on physical activity surveillance and national policies to promote physical activity have strong continuity with papers in the first physical activity Series. Rather than provide an update on deaths from physical inactivity-related non-communicable diseases (NCDs), the present section on health effects summarises new evidence on the link between physical activity and dementia. To complement the papers in the first Series, the sections on correlates of physical activity and intervention studies focus specifically on progress in low-income and middle-income countries (LMICs). Authors of each section used different methods because of the diverse nature of the topics. Progress on surveillance of physical inactivity worldwide We used comparable country estimates for physical inactivity from WHO to analyse the evolution of physical activity surveillance over the Olympic quadrennium (panel 1). In 2012, we obtained adult physical inactivity surveillance data from 122 countries representing 88·9% of the world’s population.11 For the present analyses, data were available for 146 countries, representing 93·3% of the world’s population (figure 1). The increased global population coverage was mainly due to the addition of populous nations such as Nigeria, Egypt, and Tanzania. Data were available from 82% (40 of 49) of high-income countries (HICs), 75% (41 of 55) of upper-middle-income countries (U-MICs), 69% (38 of 55) of lower-middle-income countries (L-MICs), and 77% (27 of 35) of low-income countries (LICs). The proportion of countries contributing surveillance data among adult populations increased in all regions, except southeast Asia: Africa (72–87%), Americas (43–57%), eastern Mediterranean (43–57%), Europe (68–75%), southeast Asia (82%, no change), and western Pacific (70–89%). www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 This paper forms part of the Physical Activity 2016 Series *Members listed at end of the report See Online/Comment http://dx.doi.org/10.1016/ S0140-6736(16)31070-4, http://dx.doi.org/10.1016/ S0140-6736(16)30960-6, http://dx.doi.org/10.1016/ S0140-6736(16)30929-1, and http://dx.doi.org/10.1016/ S0140-6736(16)30881-9 See Online/Series http://dx.doi.org/10.1016/ S0140-6736(16)30728-0 Department of Family Medicine and Public Health, University of California, San Diego, CA, USA (Prof J F Sallis PhD); Center for Built Environment and Health, The University of Western Australia, Perth, WA, Australia (F Bull PhD); Prevention of Noncommunicable Diseases Department, World Health Organization, Geneva, Switzerland (R Guthold PhD); Department of Health & Human Performance and Medicine, University of Tennessee, Chattanooga, TN, USA (G W Heath DHSc); Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan (S Inoue MD); Physical Activity for Health Research Centre, University of Edinburgh, Edinburgh, UK (P Kelly PhD); Department of Physiotherapy, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria (A L Oyeyemi PhD); Physical Activity, Sport and Recreation Research Focus Area, Faculty of Health Sciences, North-West University, Potchefstroom, 1 Series South Africa (A L Oyeyemi); UCSD/SDSU Joint Doctoral Program in Public Health (Global Health), San Diego, CA, USA (L G Perez MPH); School of Public Health & Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia (J Richards DPhil); and Federal University of Pelotas, Pelotas, Brazil (P C Hallal PhD) Correspondence to: Prof James F Sallis, Department of Family Medicine and Public Health, University of California San Diego, 3900 Fifth Avenue, Suite 310, San Diego, CA 92103, USA jsallis@ucsd.edu Key messages • In the 4 years since the 2012 Lancet Series that identified physical inactivity as a global pandemic, progress has been made in the breadth of national surveillance, evidence about physical activity as a protective factor for dementia, adoption of national policies and action plans, and research on correlates and interventions in low-income and middleincome countries. However, progress in the implementation of national actions to address one of the biggest health challenges of the 21st century has been insufficient. • Most countries have done population surveys of physical activity, with an extra 24 countries providing adult data and 15 countries providing adolescent data since 2012. The global prevalence of physical inactivity was about 23% for adults and about 80% for school-going adolescents, although self-report data have limitations. Few countries provided trend data for adults, and trend data for adolescents showed an increase in proportion of people who were physically inactive in most countries. • In addition to the major impact of physical inactivity on the global burden of non-communicable diseases documented 4 years ago, evidence now shows that almost 300 000 cases of dementia could be avoided annually if all people were adequately active, and this figure is increasing as the global population ages. • Research examining reasons why people are and are not physically active has increased substantially in middle-income countries, but not in low-income countries. Unlike evidence from high-income countries, urban (vs rural) residence emerged as an inverse correlate of physical activity in low-income and middle-income countries (LMICs), which is a concern given global trends toward urbanisation. These results can be used to design interventions informed by local data. • Research and evaluation of physical activity interventions has increased in LMICs. Although several examples of effective interventions have been reported, the evidence is still scarce. An important next step is to build capacity for intervention research in LMICs so interventions can be developed or adapted for local conditions, then rigorously assessed. • Due largely to the inclusion of physical activity in the WHO Global Action Plan on NCDs and the establishment of a global target to reduce inactivity by 10% by 2025, many countries have now adopted national policies or action plans to increase physical activity. However, implementation appears to be weak. Meaningful action will require increasing the infrastructure and resources for physical activity, including providing capacity-building, country technical assistance, creating effective multisector coalitions, and reaching consensus on a few highest-priority actions for each country. • Overall, physical activity surveillance, research, and policy adoption worldwide improved. However, policy implementation appears to be poor, and evidence of an increasing trend in global physical activity was absent. Thus, the global pandemic of physical inactivity remains, and the capacity for nations to respond is improving too slowly. Panel 1: WHO Global Health Observatory physical inactivity estimates Adult estimates The WHO Global Health Observatory displays comparable country prevalence estimates for physical inactivity among adults aged 18 years or older that are based on the global recommendations on physical activity for health.3,4 The recommendations state that adults should do at least 150 min of moderate-intensity, or 75 min of vigorous-intensity aerobic physical activity per week, or an equivalent combination of the two. Inclusion criteria were that data be from national or subnational cross-sectional population-based surveys undertaken with random sampling, reporting prevalence of inactivity based on the current3 or former recommendations,5 and including all domains of activity (work, household, transport, leisure). Through statistical regression modelling, when necessary, adjustments were made for the reported prevalence in case it was based on the former recommendations, known over-reporting of the International Physical Activity Questionnaire (IPAQ),6–9 survey coverage if a survey only covered urban areas, and age coverage if the 2 survey age range was narrower than 18 years or older. For comparison purposes, final estimates were adjusted to the WHO standard population.10 School-going adolescent estimates The adolescent estimates used here reflect data from the WHO Global Health Observatory for school-going adolescents aged 11–17 years, based on the global recommendations on physical activity for health that indicate that youth should engage in at least 60 min of moderate-intensity to vigorous-intensity physical activity daily.3,4 Data were included if they came from national or subnational cross-sectional school surveys covering at least 3 years of the adolescent ages, reporting prevalence for the definition above, or for doing at least 60 min of physical activity on at least 5 days per week. Through statistical regression modelling, when necessary, adjustments were made to harmonise the definition to reflect the current physical activity recommendations, and for survey coverage if only urban areas were included. www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 Series Both adult and adolescent data available Adult data available Adolescent data available No data available Not applicable 0 850 1700 3400 km Figure 1: Physical activity data availability for school-going adolescents (aged 11–17 years) and adults (aged ≥18 years) Data are from WHO Global Health Observatory, 2015. Notably, the algorithm used to estimate physical inactivity among adult populations has changed from that presented in the 2012 Lancet Series11 to align with the new standards used by the WHO Global Health Observatory.4 In 2012, inactivity was defined as not achieving 5 days of 30 min of moderate-intensity activity, or 3 days of 20 min of vigorous-intensity activity, per week, or an equivalent combination, according to the recommendations at that time.5 Reflecting scientific evidence12 and following updated physical activity recommendations,3 inactivity was defined for the present analyses as not achieving 150 min of moderate-intensity activity or 75 min of vigorous-intensity activity per week, or an equivalent combination, regardless of the weekly frequency. This recommendation is easier to achieve. Thus, the estimated prevalence of inactivity among adult populations worldwide changed from 31·1% in 2012 to 23·3% in 2016, a reduction that primarily reflects changes in the recommendations rather than a real increase in physical activity. The lack of substantial change is confirmed by findings from the 12 countries with trend data that included domains of leisure, transportation, and occupation. Six countries (Argentina, Belgium, Iran, Kuwait, Mongolia, and Singapore) reported a numerical increase in the prevalence of inactivity, and six countries (Maldives, New Zealand, South Korea, Seychelles, South Africa, and USA) reported a decrease (for references for trends see appendix p 1). Notable disparities remain in the prevalence of physical inactivity between men and women, with 137 of the 146 countries showing higher inactivity among women.4,13 Older age groups continue to be at higher risk for inactivity, with the oldest age category showing more than double the prevalence of the youngest (aged 80 years or older, 55·3% vs aged 18–29 years, 19·4%). Improvements in global surveillance coverage of physical activity were also documented for school-going adolescents. In the 2012 publication11 we analysed data of adolescents aged 13–15 years from 105 countries. For the present analyses, estimates were available for adolescents aged 11–17 years from 120 countries4 (figure 1), with data mainly from the Global School-based Student Health Survey14 and the Health Behaviour in School-aged Children Study.15 The population coverage of adolescent surveillance increased from 68·0% in 2012 to 76·3% in 2016. Availability of selfreport data for adolescents was 81·6% in HICs (40 of 49), 70·9% in U-MICs (39 of 55), 60·0% in L-MICs (33 of 55), and 20·0% in LICs (seven of 35). The proportion of countries contributing surveillance data from adolescents increased in all world regions, except Africa and southeast Asia: Africa (30%, no change), Americas (57–77%), eastern Mediterranean (57–76%), Europe (64–68%), southeast Asia (55%, no change), and western Pacific (33–78%). We identified 50 countries that reported comparable trend data for adolescents. For 32 of the 50 countries, the prevalence of inactivity numerically increased, whereas for the other 18, prevalence of inactivity decreased. Consistent with the 2012 Series, adolescent inactivity prevalence was defined as not achieving at least 60 min of moderate to vigorous physical activity daily.3,11 Inactivity prevalence continued to be extremely high, with a global average of 78·4% for boys and 84·4% for girls. In the vast majority of countries (115 of 120 countries with data), more than a quarter of school-going adolescents did not reach the recommended level of activity.4,13 The apparent higher inactivity prevalence for adolescents than adults was partly a result of the higher recommended level for youth. However, prevalence cannot be compared directly across age groups because the questionnaires differed greatly. Given known limitations of self-reports, the use of objective physical activity measures, such as accelerometers, to estimate national prevalence is growing. A 2015 review16 of accelerometer studies in adults found 76 studies across 36 countries that had www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 See Online for appendix 3 Series used devices in at least 400 participants, with 13 identified as national population-based cohorts. From this review, eight studies from seven HICs met our definition of reporting national prevalence.17–25 Prevalence estimates varied from 1% to 52% for meeting physical activity recommendations. However, estimates were not comparable across countries as a result of large variations in data collection methods, data processing, and scoring. Experts agree that standardised accelerometer methods are needed,16 and prevalence estimates from accelerometers should not be compared with self-report data.25 In children and adolescents (aged 5–19 years) we found accelerometer-based population prevalence estimates of engaging in 60 min or more of physical activity daily in six studies from five HICs.17,21,23,26–28 Once again, prevalence esti mates were not comparable and reflected methodological inconsistencies. The International Children’s Accelero metry Database (ICAD) had accelerometry data from 20 studies worldwide, and allowed comparisons because of standardised methods,29 but most samples were not nationally representative. ICAD data also showed large between-country physical activity prevalence variations ranging between 15% and 28%.29 Panel 2: Formulae for calculation of population attributable fraction (PAF) Formula 1 (unadjusted PAF) Formula 1 provides an estimate for the PAF assuming no confounding exists between physical inactivity and dementia. It requires prevalence data for physical inactivity in the population (Pe) and an unadjusted relative risk (RRunadj); PAF (%)= Pe(RRunadj – 1) Pe(RRunadj –1) + 1 × 100 Formula 1 provides a crude estimate for the PAF, but calculating an adjusted PAF is indicated because several confounding factors for physical inactivity and dementia have been previously identified (eg, genetic markers). Formula 2 (adjusted PAF) Formula 2 provides an estimate for the PAF assuming that confounding exists between physical inactivity and dementia. It requires prevalence data for physical inactivity in people eventually developing dementia (Pd) and the adjusted relative risk (RRadj); PAF (%)= Pd(RRadj – 1) × 100 RRadj Formula 2 provides a conservative estimate for the PAF because some of the confounders included in the calculation of the RRadj are exacerbated by physical inactivity (eg, physical function). 4 Comment More countries are collecting physical activity surveillance data, although reporting on adolescents in LICs has not improved much. About a quarter of adults and 80% of adolescents were not meeting guidelines according to self-report data. Though trend data were scarce, no evidence has shown that physical inactivity declined globally. More countries are using objective measures for surveillance, demonstrating feasibility. To promote wide use of objective measures for surveillance, methods should be standardised, and data collection in LICs should be supported. Health consequences of physical inactivity: focus on dementia In the 2012 Lancet Series, Lee and colleagues30 reported large global population attributable fractions (PAFs) of physical inactivity for coronary heart disease (6%), type 2 diabetes (7%), breast cancer (10%), colon cancer (10%), and all-cause mortality (9%). These estimates have probably changed little, but understanding of other health consequences of physical inactivity has progressed. The most notable of these might be the association between physical activity and cognition. Growing evidence supports the role of physical activity in developing and maintaining cognitive capacity throughout life. Previous work has focused heavily on biophysiological plausibility derived from animal studies and findings from neuroanatomy.31 Methodological advances have enabled studies that show the impact of physical activity on neurogenesis, neuroelectric potentiation, and neurochemical factors in the hippocampus and areas of the brain responsible for higher levels of executive control during childhood.32 These findings are consistent with substantial evidence of improved cognitive function and scholastic achievement in physically active children.31–33 In adult populations, a large body of observational data34 suggests that physical activity can contribute to preventing dementia, and some experimental evidence has shown neurobiological changes in response to visuomotor training,35 which supports the plausibility of a causal relationship. This relationship is of increasing importance in an ageing population globally. WHO estimates that 47·5 million people are living with dementia.36 Approximately 7·7 million new diagnoses are made each year worldwide, and 58% of existing cases are from LMICs.36,37 60–70% of dementia cases are thought to be caused by Alzheimer’s disease, and previous estimates suggest that 12·7% of cases could be avoided worldwide if physical inactivity was eliminated.36,38 Although this calculation was made using an adjusted relative risk (RR), Norton and colleagues38 applied a formula for unadjusted estimates of PAF. Consequently, assessment of an appropriately adjusted PAF is indicated, and we focused on the broader diagnosis of dementia, which has not been assessed previously. www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 Series Overall Prevalence of inactivity Prevalence of inactivity in in population people eventually developing dementia Population attributable fraction with unadjusted relative risk Population attributable fraction with adjusted relative risk 23·8% (4·1–65·0) 12·3% (2·4–27·7) 3·8% (0·7–10·5) 3·4% (0·9–7·6) 27·9% (4·8–76·2) WHO region Africa 20·8% (5·8–46·9) 24·4% (6·8–55·0) 10·9% (3·3–21·7) Eastern Mediterranean 38·2% (15·6–61·0) 44·8% (18·3–71·5) 18·4% (8·4–26·5) 6·2% (2·5–9·9) Europe 22·8% (9·5–42.9) 26.7% (11·1–50·3) 11·8% (5·3–20·2) 3·7% (1·5–6·9) Latin America and Caribbean* 31·1% (13·3–63·6) 36·4% (15·6–74·5) 15·5% (7·3–27·3) 5·0% (2·1–10·3) North America 27·8% (23·2–32·4) 32·6% (27·2–38·0) 14·0% (12·0–16·0) 4·5% (3·7–5·2) Southeast Asia 14·8% (4·1–30·7) 17·3% (4·8–36·0) 8·0% (2·4–15·3) 2·4% (0·7–5·0) Western Pacific 24·0% (5·6–65·0) 28·1% (6·6–76·2) 12·4% (3·2–27·7) 3·9% (0·9–10·5) High 28.7% (9.5–61.0) 33·6% (11.1–71.5) 14·5% (5·3–26·5) 4·6% (1·5–9·9) Upper middle 27·9% (14·8–65·0) 32·6% (17·3–76·2) 14·1% (8·0–27·7) 4·5% (2·4–10·5) Lower middle 20·6% (5.6–45.1) 24·1% (6.6–52.8) 10·8% (3·2–21·0) 3·3% (0·9–7·3) Low 14·8% (4·1–27·5) 17·3% (4·8–32·2) 8·0% (2·4–14·0) 2·4% (0·7–4·4) World Bank income classification Data are median (range of median for all relevant countries); details of country-specific values are provided in appendix p 7. Physical inactivity was defined as insufficient physical activity to meet current recommendations. *WHO region of the Americas split into Latin America and Caribbean, and North America to ensure consistency with previously published paper.30 Table 1: Summary of estimates of prevalence of physical inactivity and population attributable fractions for dementia associated with physical inactivity We applied similar methods to those described for the analysis of disease burden in the 2012 Lancet Series to calculate both adjusted and unadjusted PAFs (panel 2).30 We searched MEDLINE and Embase databases using keywords related to physical activity (“physical activity”, “motor activity”, “energy expenditure”, “walking”, “exercise”) and dementia (“dementia”, “cognitive decline”, “cognitive impairment”, “cognition”, “Alzheimer’s disease”) as of April 1, 2015. We screened 9396 titles to identify the most recent peer-reviewed meta-analysis reporting an adjusted RR.34 The unadjusted RR was calculated using crude data, and age-adjusted data from the papers was included in this meta-analysis (appendix p 4). During our literature review we also identified relevant cohort studies to estimate the prevalence of physical inactivity in people who eventually developed dementia. This identification involved calculating an adjustment factor for each study by taking a ratio of baseline physical inactivity for subsequent dementia cases to baseline physical inactivity for the entire study population (appendix p 5).30 The average adjustment factor across studies was 1·17 (SE 0·07). This adjustment factor was applied to the most recent WHO data to estimate the prevalence of physical inactivity in subsequent dementia cases.13 The results are summarised in table 1. Blondell and colleagues34 pooled maximally adjusted RRs for the association between physical activity and dementia. The pooled RR was 0·86 (95% CI 0·76–0·97). Taking the inverse to obtain the adjusted RR for inactivity, we calculated an RR of 1·16 (95% CI 1·03–1·32). Our calculation of the pooled unadjusted RR was 1·59 (95% CI 1·35–1·82). The adjusted PAF of physical inactivity for dementia ranged from 0·7% (Nepal) to 10·5% (Cook Islands), with an overall median of 3·8%. This finding suggests that 292 600 new dementia cases could be avoided globally each year if all people were active. If physical activity does not improve, this number is likely to increase substantially as the proportion of the global population who are older adults (aged 65 years and older) continues to grow. Table 1 also summarises differences in PAF patterns according to WHO regions and the 2014 World Bank classifications of income status. When considering WHO regions, the median PAF was lowest in southeast Asia (2·4%) and highest in the eastern Mediterranean (6·2%). The median PAF was lowest in LICs (2·4%) and highest in HICs (4·6%). We also calculated PAFs by country and applied 10 000 Monte Carlo simulations to estimate 95% CI (appendix p 7). The adjusted PAF of physical inactivity for dementia appears to be modest compared with the disease outcomes reported in the 2012 Lancet Series, which ranged from about 6% to 10%.30 However, the previous calculations were based on a higher prevalence of physical inactivity globally, primarily because of the revised 2010 physical activity recommendations3 (see preceding section on surveillance of physical inactivity). When using the same physical activity data and recommendations as applied by Lee and colleagues,30 we calculated a median PAF of 5·7% for dementia. In reporting the PAFs we focused on the adjusted results and consequently might have overadjusted for factors on the causal pathway. The use of underestimated physical inactivity prevalence could have also contributed to conservative PAF estimates. Finally, despite using low versus high physical activity for calculating the RRs, the www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 5 Series comparison group was not truly inactive, and our results might still be conservative relative to estimates for other risk factors (eg, reference group for calculating a PAF for smoking is non-smokers). Comment Dementia is growing as a global health priority because of the rapidly increasing numbers of older adults. Evidence about the role of physical inactivity in dementia makes it a timely topic for analysis of global health impact. The PAF of physical inactivity for dementia was 3·8%, which is substantial but lower than PAFs for other NCDs. Progress in research on correlates and determinants of physical activity in LMICs Understanding physical activity correlates (crosssectional) and determinants (prospective) is crucial to designing effective interventions that target evidencebased mechanisms of change. Among recommendations to use objective physical activity measures, apply prospective designs, and target understudied popu lations,39 research in LMICs is especially urgent, because almost three-quarters of NCD deaths (28 million) occur in these countries, indicating a large potential for preventive interventions.4,13 To determine progress since the 2012 Lancet Series39 we systematically searched articles on physical activity correlates in LMICs using similar methods to previous reviews39,40 (appendix pp 10–13). We screened 1383 articles and identified 197 relevant papers (appendix pp 13–30). The number of publications from LMICs increased from 7·2 publications per year in 1999–2011 to 32·8 publications per year between 2012 and February, 2015, while the number of countries in which studies were done was stable at 22–23 countries. Most studies were from U-MICs, especially Brazil and China. Improvements to methods included measure ments of multiple physical activity domains (eg, transport, recreation) and use of accelerometers, but 94·2% of studies were cross-sectional rather than prospective. The significance and direction of physical activity correlates reported in five or more studies are summarised in table 2. Studies of adults (aged 18–64 years) and older adults (aged 65 years and older) had mixed evidence of positive associations of younger age and male sex with higher physical activity, with a few studies showing inverse associations. Differences in sociocultural roles for older adults and women in LMICs might explain these different results. Regarding psychological and social factors, most of the directions of association were similar to those from HICs. For physical environmental factors, proximity to destinations, neighbourhood aesthetics, and access to open space were consistent correlates of higher physical activity, similar to results from HICs. Some inconsistent results with HICs had important implications. In particular, high socioeconomic status and urban (vs rural) residence were related to lower 6 physical activity among adults and youth. Rapid urbanisation, access to motorisation, and increases in sedentary work could be potential drivers of inactive lifestyles in LMICs.41–43 Considering the increasing urbanisation worldwide,44 activity-friendly urban design could be an effective strategy to mitigate the impacts of urbanisation on physical activity in LMICs. In studies of children and adolescents, male sex, higher self-efficacy, participating in school sports, higher social support, proximity to destinations, and access to open space were consistent positive correlates. As was the case with adults, high socioeconomic status and urban residence emerged as inverse correlates of physical activity. Comment Publications on physical activity correlates from LMICs increased substantially since 2012. However, most studies were from a few U-MICs. The continuing dearth of studies from LICs highlights the gap between where research is done and where the largest public health impacts of physical inactivity are located.45 Consistent correlates were found at individual, social, and environ mental levels of influence, and most of the directions of association were similar to those from HICs. Implications of these results are that interventions should be developed that operate at multiple levels of influence and are informed by correlates of research from LMICs. Progress in research on physical activity interventions in LMICs The 2012 Lancet Series paper on physical activity interventions identified a paucity of studies in LMICs.46 Therefore, this update identified intervention studies done in LMICs. We searched the English, Spanish, and Portuguese 2010–15 literature using the same search methods as in our 2012 paper.46 We identified 147 potential papers using multiple search engines and completed full reviews of 64 relevant papers. The table in the appendix p 31, summarises study characteristics and results for the most relevant and highest-quality 15 papers. Intervention strategies to increase physical activity in whole populations have been categorised as communitywide, informational, behavioural, social, policy, and built environmental approaches.39,47,48 Intervention strategies were classified in a manner consistent with our 2012 Lancet Series paper.46,49,50 Multilevel approaches that operate across personal (eg, biological, psychological), social (eg, family, co-workers), and built environmental (eg, neighbourhoods designed so that homes are near shops and services, access to parks, bicycle facilities) levels of influence could be more successful in increasing physical activity than those targeting only one level.12 In this section we highlight some of the best LMIC interventions in each category. Case studies describing characteristics of several exemplary interventions from LMICs are in the appendix p 35. www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 Series Community-wide campaigns Community-wide campaigns often use multicomponent (eg, media, behavioural, social, policy, and environ mental), multisector (eg, public health, transportation, recreation, health care), and multisite (eg, work, school, community organisation) interventions.46 Campaigns usually represent large-scale, high-intensity program ming and often use multiple communication media to raise programme awareness and disseminate health messages. Community-wide inter ventions among Examined direction Adults and elderly (n=124) Children and adolescents (n=73) Number of examined papers Directions of associations Number of examined papers Directions of associations 78 + 37 + 9 00 ·· ·· Demographic and biological factors Age Younger Occupation or parent occupation Manual or blue collar Education High education 68 + ·· ·· Gender Male 57 + 37 ++ Cardiovascular risks High risk 12 0 ·· ·· Family income and socioeconomic status High income or socioeconomic status 52 – 34 – Marital status Married 43 0 ·· ·· Overweight and obesity Overweight or obese 30 – 21 0 Race and ethnicity Non-white 18 00 Parental education High parental education 6 00 29 0 Psychological, cognitive, and emotional factors Perceived barriers Barrier present 7 0 ·· ·· Perceived benefits Benefits present 5 ++ ·· ·· Perceived health and fitness Healthy or high fitness 20 ++ ·· ·· Psychological health and distress Good psychological health 7 0 ·· ·· Self-efficacy High self-efficacy 7 ++ 8 ++ ·· Behavioural attributes and skills Alcohol More drinking 12 0 ·· Dietary habits High quality of diet 5 0 ·· ·· School sports, physical education, and supervised physical activity Good education ·· ·· 13 ++ Smoking status Smoker 17 0 6 0 Sedentary behaviour (TV time, screen time, and sedentary time) Highly sedentary ·· ·· 19 – Social and cultural factors Exercise and physical activity role models Role model present ·· ·· 5 + Social support from friends and peers Support present 7 ++ 8 ++ Social support from spouse and family Support present 5 0 9 ++ Physical environment factors Access to destinations (land use mix)*: objective measurement Good access 7 ++ ·· ·· Access to destinations (land use mix): perceived measurement Good access 12 ++ 9 ++ Lighting Adequate lighting ·· ·· ·· ·· Enjoyable scenery and aesthetics Good scenery 7 + ·· ·· Traffic Safe level of traffic 16 00 5 0 Neighbourhood safety from crime Safe neighbourhood 21 0 7 0 Sidewalks, cycle lanes, and paths Present 14 00 5 0 Urban location of residence Urban living 17 – 12 – Access to open space (eg, parks, trails, green space) Good access 14 + 5 ++ Walkability (composite) Walkable ·· ·· ·· ·· Street connectivity High connectivity 6 – ·· ·· Residential density High density 10 0 ·· ·· Safety of facilities (eg, park safety, trail safety) Safe facilities ·· ·· ·· ·· Correlates or determinants for which less than five papers were reported were excluded from the table. ++=repeatedly documented positive association with physical activity. +=weak or mixed evidence of positive association with physical activity. 00=repeatedly documented absence of association with physical activity. 0=weak or mixed evidence of no association with physical activity. – –=repeatedly documented negative association with physical activity. –=weak or mixed evidence of negative association with physical activity. ··=not enough data available. *Land use mix refers to homes being near shops, services, and jobs, thus providing destinations within walking distance. Table 2: Directions and strength of relationship of physical activity correlates or determinants in low-income and middle-income countries www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 7 Series LMICs that used multisector collaborations were reported from Iran,51 China,52 South Africa,53 Vietnam,54 and India and Indonesia.55 Some campaigns targeted only physical activity, and others targeted multiple risk factors (appendix p 31). These studies, mostly using quasi-experimental designs, showed that evidence for community-wide campaigns has grown in number and quality among LMICs since our 2012 review.46 Because of the diversity of approaches, contexts, and assessment methods, we could not identify principles of effective strategies used in these community-wide interventions. Social support interventions in community settings Strategies to increase social support for physical activity include buddy systems, behavioural contracting, and walking groups.46 Promising interventions in LMICs that represent this approach were found with rural com munities in India,56 health-care workers in South Africa,57 and women civil servants in Vanuatu, a South Pacific island.58 Physical activity classes in community settings Providing physical activity classes in public settings was shown to be a promising strategy.46 Parra and colleagues59 showed the effectiveness of this strategy in Recife, Brazil. These results were supported by studies in Aracaju, Brazil,60 and Santiago, Chile.61 School-based interventions School-based interventions can increase physical activity among children during and after school.46 Investigations in LMICs showed mixed results, with a study of classroom physical activity in Beijing, China, showing effectiveness over 2 years,62 and a physical education intervention with favorable effects at one year63 but a controlled study of girls in Karachi, Pakistan, showing no effects.64 Further studies of school-based strategies in LMICs are encouraged to assess co-benefits for cognitive function and school performance given the positive findings for these outcomes in HICs31–33,65 and their importance for school officials. Community-wide policies and programmes Community-wide policies and planning to improve built environments, combined with efforts to promote physical activity, have shown promise in Latin America.46 This intervention strategy not only uses information to motivate individual behaviour change, but also provides built and social environmental support to sustain physical activity.46 A study in Bogotá, Colombia, reported modest effectiveness among survey respondents who reported regularly using Ciclovia (streets closed to cars but open to cyclists and pedestrians) and Cicloruta (protected bicycle facilities) compared with irregular users.66 The use of sport-fordevelopment programmes is an emerging strategy in sub-Saharan Africa, where sport is used to promote 8 physical activity and community cohesiveness, as well as to enhance human capital.67 Comment 15 studies of physical activity interventions in LMICs were identified, representing an increase from these resource-constrained contexts. Multiple types of inter ventions were assessed, and many of the studies reported increased physical activity. Quality of programme assessment was variable, so investigators are encouraged to apply a standard yet flexible approach to programme assessment.68 These studies provided promising evidence that population-wide physical activity interventions can be effective in LMICs, especially those in which inter sectoral collaboration exists. However, documentation of the development, adaptation, and assessment of physical activity interventions among LMICs needs to be improved. Greater implementation of evidence-based interventions could help control NCDs in LMICs. Progress on national physical activity policies Increasing physical activity requires multiple strategies, including policies in multiple sectors that lay out the problem, solutions, stakeholders, timelines, and desired outcomes. Without adequate national public policy, public health responses tend to be restricted in scope and strength, uncoordinated, underfunded, and shortterm. Since the 1990s, there has been a call for national physical activity policies and implementation (or action) plans,69,70 but response was poor. The first global policy outlining national actions to address physical inactivity was not launched by WHO until 2004. The Global Strategy for Diet, Physical Activity and Health71 laid out the epi demiological rationale for systematic national policy and action to increase physical activity. This call was reinforced in the UN Declaration on NCDs in 201172 and further defined in the Global Action Plan (GAP) for the Prevention and Control of NCDs, 2013–20. GAP positioned physical inactivity as one of the key NCD risk factors and set for all countries the target of achieving a 10% decrease in inactivity by 2025 (relative to each country’s baseline).73 Given these notable developments in global policy, it is timely to ask what progress has been made in the adoption and implementation of national physical activity policy in the decade since the WHO global strategy recommendations were made. Collecting data on physical activity policy is difficult because of publication in different languages, definitional differences, relevance of multiple government ministries, accessibility of government reports, and challenges in verifying content. The development of physical activity policy audit tools74 allows a more systematic approach, and several initiatives have commenced to track national policy and action initiatives.75-–77 In 2000, WHO initiated an assessment of NCD policy development and country capacity, and since 2013 this survey has formed part of the Global NCD Monitoring and Evaluation framework.78 www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 Series A 2010 2013 2015 100 90 Proportion of countries (%) 80 70 60 50 40 30 20 10 0 World Africa Americas Eastern Mediterranean Europe Southeast Asia Western Pacific Region B 100 90 Policy exists Policy is operational† 80 Proportion of countries (%) Figure 2A shows the status of national policy on physical activity in 2010, 2013, and 2015 globally and by regions as assessed by WHO. By 2015, 91% of the 160 countries responding at all three timepoints reported having a national physical activity policy. This proportion has increased since 2010 (75%), which might reflect the increased global focus on NCDs and GAP. Notable progress was seen in countries in the African region (from 45% in 2010 to 100% in 2015), such that by 2015 all but the Americas region had over 90% of countries reporting the presence of physical activity in national policy. A decade ago only 29% of the 133 responding countries reported having a physical activity policy (figure 2B). However, having a policy and implementing the policy are distinctly different. Monitoring surveys done in 2010, 2013, and 2015 (figure 2B) included questions on the status of each policy, and results reveal a notable gap in policy implementation. In 2010, 75% of countries reported having a physical activity policy but only 44% reported their countries’ policy to be operational—ie, both active and funded (figure 2B). The implementation gap remains clearly visible in 2013 and 2015, albeit narrowing (57% and 71% reported operational plans, respectively). Although this trend is positive, 2015 data reveal that globally approximately a quarter of national policies on physical activity are not being put into practice. Without policy implementation, substantial improvements in population physical activity are unlikely. Despite good progress in developing national physical activity policy, the substantial implementation gap indicates countries are having difficulties in translating policy intent into action. Many local contextual challenges could occur, but three common barriers to policy action are highlighted here. The first barrier is an insufficient workforce to implement physical activity policies. WHO 2013 data show that 94% of countries now have an NCD unit within their ministry of health, an increase from 89% of countries in 2010 and 61% in 2000.79 However, virtually no data are available on dedicated resources for implementation of physical activity strategies. Insufficient numbers of trained workers with knowledge and skills to develop, implement, and assess programmes and to build intersectoral partnerships will hinder a country’s ambitions to increase physical activity. Experience in training a professional workforce and strengthening research capacity on physical activity has been accumulating, especially in the Americas. More than 50 physical activity and public health training courses coordinated by the US Centers for Disease Control and Prevention have produced over 3500 graduates who can develop and deliver national, state, and local actions.80 A second barrier to progress is the need to form and sustain effective multisector partnerships, deemed necessary because the policies that hinder physical activity are within transport, education, sport, recreation, and urban planning sectors.81 Countries are showing 70 60 50 40 30 20 10 0 2005* 2010 2013 2015 Year Figure 2: Progress on national physical activity policies (A) Presence of national policy, strategy, or action plan (ie, physical activity plan or have physical activity incorporated in an integrated non-communicable disease plan) on physical activity in 160 countries by WHO region. Data were provided by WHO from Country Capacity Surveys done in 2010, 2013, and 2015; analysis includes only 160 countries with responses at all three timepoints. (B) Global progress and implementation of national policy and action plans on physical activity. Data are from WHO Country Capacity Survey Reports 2005, 2010, and 2013; unpublished data for 2015 were provided by WHO; n=160 countries included except in 2005 in which n=133 countries. *2005 survey item not identical to later years. †Operational refers to reporting the plan is being implemented and funded. signs of establishing multisector collaborations to address NCDs. In 2013, 94% of countries reported such a mechanism, an increase from 61% in 2010.78 However, only 33% of these countries reported that the committees remained operational in 2013, which is further evidence of the implementation gap and that securing crosssectoral engagement in physical activity policies is a common challenge. The third barrier to policy progress is the absence of clarity on the actions most likely to be effective and feasible in a given context. Until the global action plan on NCDs in 2013,73 most of the national policies on physical activity came from Europe, North America, and Australasia. These policies drew on extensive scientific evidence, largely from the same regions. A frequent request from other regions is for support to develop the www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 9 Series evidence and select, adapt, and implement solutions that fit local cultural, religious, geographical, and economic contexts. Although the preceding section of this paper reports progress in physical activity intervention studies in LMICs, a stronger emphasis on physical activity interventions is needed, linked with national policies, to accelerate implementation of effective and promising strategies on a large scale. A clear consensus on effective interventions will support national policy making, and practical resources and toolkits can support imple mentation, particularly in LMICs. Civil society developed a consensus document of the seven best investments for increasing physical activity,82 and a toolkit to guide implementation that is tailored to national contexts is warranted. The rapid adoption of national physical activity policies creates an opportunity and the need to create tools and resources to support improved implementation in each country, with a special focus on LMICs. Comment Almost all ministries of health now have NCD units, and most countries have a physical activity policy or action plan. However, implementation of physical activity policies appears to be scarce, probably because of an insufficient workforce with relevant skills, multisector partnerships, and clarity on the most effective interventions. Training programmes in physical activity and public health are available but need to be expanded. Conclusion In the 4 years since the 2012 Lancet Series on physical activity,2 global progress on the topics covered in the present paper has been modest, yet each sign of progress indicates the shortcomings of current actions. More countries are collecting physical activity surveillance data than in previous years, but physical activity is not increasing worldwide. Although many studies show physical activity enhances brain health, this new knowledge has not yet been translated into action. Evidence on correlates of physical activity is increasing in LMICs, but few studies have been done in LICs. Although it is encouraging that effective interventions are being assessed in LMICs, strong assessment methods and tailoring to local contexts are needed. National physical activity policies and plans have been adopted by almost all countries, yet major challenges with implementation remain. Progress on physical activity has been far from proportionate to the documented burden of disease from physical inactivity in countries of all income levels.13,30 The most progress might have been made in putting physical activity on the health agenda of LMICs. LMICs are laying the groundwork for effective public health action on physical activity, but it is not clear where the resources will be found to scale up effective interventions, build a physical activity workforce in public health, expand research in LMICs, and take bold 10 initiatives to alter policies that will increase physical activity in all countries. Contributors All authors drafted sections and edited the manuscript. JFS and PCH conceptualised the paper, and JFS coordinated the writing process. RG managed data collection. RG, JR, and PCH did the analyses. FB, JR, PCH, GWH, SI, PK, ALO, and LGP conducted searches. Declaration of interests JFS has received grants and personal fees from the Robert Wood Johnson Foundation outside of this article, grants and non-financial support from Nike outside of this article, and is a consultant and receiver of royalties from Sportime/SPARK of School Specialty Inc. RG is a staff member of the World Health Organization. All other authors declare no competing interests. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy, or views of the World Health Organization. Lancet Physical Activity Series 2 Executive Committee Adrian E Bauman, Ding Ding, Ulf Ekelund, Pedro C Hallal, Gregory W Heath, Harold W Kohl 3rd, I-Min Lee, Kenneth E Powell, Michael Pratt, Rodrigo S Reis, James F Sallis. Acknowledgments We thank Shiho Amagasa (Department of Preventive Medicine and Public Health, Tokyo Medical University, Japan), Noritoshi Fukushima (Department of Preventive Medicine and Public Health, Tokyo Medical University, Japan), Andrea Ramirez Varela (PhD student, Post Graduate Program in Epidemiology, Universidade Federal de Pelotas, Brazil), Noriko Takeda (Division of Liberal Arts, Kogakuin University, Japan), Debra Rubio (Department of Family Medicine and Public Health, University of California, San Diego, CA, USA), Ding Ding (Sydney School of Public Health, University of Sydney, Australia), and I-Min Lee (Harvard Medical School and Harvard T H Chan School of Public Health, Boston, MA, USA). We thank reviewers Loretta DiPietro (Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA) and Lars Bo Andersen (Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark) for their valuable critiques. References 1Bauman A, Murphy NM, Matsudo V. Is a population-level physical activity legacy of the London 2012 Olympics likely? J Phys Act Health 2013; 10: 1–3. 2Hallal PC, Bauman AE, Heath GW, Kohl HW, Lee IM, Pratt M. Physical activity: more of the same is not enough. Lancet 2012; 380: 190–91. 3 WHO. Global recommendations on physical activity for health. Geneva, Switzerland: World Health Organization, 2010. 4 WHO Global Health Observatory. Insufficient physical activity. Geneva, Switzerland: World Health Organization, 2015. http://apps. who.int/gho/data/node.main.A892?lang=en (accessed Jan 22, 2016). 5Pate RR, Pratt M, Blair SN, et al. 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Assessment of national capacity for noncommunicable disease prevention and control. Geneva, Switzerland: World Health Organization, 2001. 80 International Society of Physical Activity and Health. Capacity building for the promotion of physical activity: achievements, lessons learned, and challenges. 2014. www.rafapana.org/files/ arquivos/2013_reporte_cursos_final_en.pdf (accessed Nov 1, 2015). 81Sallis JF, Floyd MF, Rodríguez DA, Saelens BE. Role of built environments in physical activity, obesity, and cardiovascular disease. Circulation 2012; 125: 729–37. 82 Global Advocacy for Physical Activity: Advocacy Council of International Society for Physical Activity and Health. Non communicable disease prevention: Investments that work for physical activity. Int Soc Phys Act Health; 2011. https://www. dropbox.com/s/ko7dknkxy9bxe7y/InvestmentsWork_FINAL-low. pdf?dl=0 (accessed Nov 1, 2015). www.thelancet.com Published online July 27, 2016 http://dx.doi.org/10.1016/S0140-6736(16)30581-5 Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Sallis JF, Bull F, Guthold R, et al. Progress in physical activity over the Olympic quadrennium. Lancet 2016; published online July 27. http://dx.doi. org/10.1016/S0140-6736(16)30581-5. Appendix 1: For Surveillance Section Reference list for physical activity trend data Argentina Ministerio de Salud de la Nación. Encuesta nacional de factores de riesgo 2005. Buenos Aires, Argentina: Ministerio de Salud de la Nación, 2006. Ministerio de Salud de la Nación. Segunda encuesta nacional de factores de riesgo para enfermedades no transmisibles. Buenos Aires, Argentina: Ministerio de Salud de la Nación, 2011. Ministerio de Salud de la Nación. 3o Encuesta nacional de factores de riesgo para enfermedades no transmisibles. Buenos Aires, Argentina: Ministerio de Salud de la Nación, 2014. Ferrante D, Virgolini M. National Risk Factor Survey 2005: Main Results. Prevalence of Cardiovascular Risk Factors in Argentina. Rev Argent Cardiol 2007;75:20-9. Belgium Scientific Institute of Public Health. Highlights of the Belgian Health Interview Survey 2008. Brussels, Belgium: Scientific Institute of Public Health, 2011. Tafforeau J. Enquête de santé par interview, Belgique 2008. La pratique d’activités physiques. Bruxelles, Belgique: Institut Scientifique de Santé Publique. Drieskens S, Charafeddine R, Demarest S, Gisle L, Tafforeau J. Van der Heyden J. Health Interview Survey, Belgium, 1997 - 2001 - 2004 - 2008 - 2013: Health Interview Survey Interactive Analysis. Brussels, Belgium: WIV-ISP. https://hisia.wiv-isp.be/ (accessed Sept 1, 2015). Iran Koohpayehzadeh J, Etemad K, Abbasi M, et al. Gender-specific changes in physical activity pattern in Iran: national surveillance of risk factors of non-communicable diseases (2007-2011). Int J Public Health 2014;59:231-41. Asgari F, Mirzazadeh A, Miri HH. Iran Non-communicable Diseases Risk Factors Surveillance Data Book for 2007. http://www.who.int/chp/steps/iran/en/ (accessed Aug 10, 2015). World Health Organization. WHO STEPS. Chronic Disease Risk Factor Surveillance Data book I. R. Iran 2008. http://www.who.int/chp/steps/iran/en/ (accessed Aug 10, 2015). World Health Organization. WHO STEPS. Chronic Disease Risk Factor Surveillance Data book I. R. Iran 2009. http://www.who.int/chp/steps/iran/en/ (accessed Aug 12, 2015). 1 Kuwait Ministry of Health of the State of Kuwait. STEPS report Kuwait 2006. Kuwait, Kuwait: Ministry of the State of Kuwait, 2008. http://www.who.int/chp/steps/STEPS_Report_Kuwait.pdf (accessed Oct 14, 2015). World Health Organization. Kuwait STEPS Survey 2014. Fact Sheet. http://www.who.int/chp/steps/kuwait/en/ (accessed Oct 14, 2015). Maldives World Health Organization. Survey on Non Communicable Disease Risk Factors Maldives, 2004. http://www.who.int/chp/steps/maldives/en/ (accessed June 20, 2015). Personal communication with authors. World Health Organization. WHO STEPS survey on risk factors for noncommunicable diseases, Maldives, 2011. http://www.who.int/chp/steps/maldives/en/ (accessed June 20, 2015). Personal communication with authors. Mongolia World Health Organization Western Pacific Region. Mongolian STEPS Survey on the Prevalence of Noncommunicable Disease Risk Factors 2006. http://www.who.int/chp/steps/mongolia/en/ (accessed July 23, 2015). World Health Organization Western Pacific Region. Mongolian STEPS Survey on the Prevalence of Noncommunicable Disease Risk Factors 2009. http://www.who.int/chp/steps/mongolia/en/ (accessed July 23, 2015). Personal communication with authors. New Zealand Ministry of Health. New Zealand Health Survey: Annual update of key findings 2012/13. Wellington, New Zealand: Ministry of Health, 2013. Ministry of Health. New Zealand Health Survey Methodology Report 2012/13. Wellington, New Zealand: Ministry of Health, 2013. Ministry of Health. New Zealand Health Survey: Adult data tables: Health Status, health behaviours and risk factors. http://www.health.govt.nz/publication/new-zealand-health-survey-annual-update-key-findings-2012-13 (accessed July 29, 2015). Sport and Recreation New Zealand (SPARC). The New Zealand Physical Activity Questionnaires. Report on the validation and the use of the NZPAQ-LF and the NZPAQ-SF self-report physical activity survey instruments. Wellington, New Zealand: Sport and Recreation New Zealand, 2004. 2 Ministry of Health. A Portrait of Health. Key Results of the 2006/07 New Zealand Health Survey. Wellington, New Zealand. Ministry of Health, 2008. Republic of Korea Ministry of Health and Welfare and Korea Centers for Disease Control and Prevention. Korea National Health and Nutrition Examination Survey. Major Results. https://knhanes.cdc.go.kr/knhanes/eng/sub01/sub01_05.do (accessed Oct 13, 2015). Personal communication with authors. Seychelles Bovet P, William F, Viswanathan B, et al. The Seychelles Heart Study 2004: methods and main findings. Victoria, Republic of Seychelles: Ministry of Health and Social Development, 2007. http://www.who.int/chp/steps/seychelles/en/ (accessed Oct 5, 2015). Bovet P, Viswanathan B, Louange M, Gedeon J. National Survey of Noncommunicable Diseases in Seychelles 2013-2014 (Seychelles Heart Study IV): methods and main findings. Victoria, Republic of Seychelles: Ministry of Health and Social Development, 2015. http://www.who.int/chp/steps/seychelles/en/ (accessed Oct 5, 2015). Singapore Ministry of Health Singapore. National Health Surveillance Survey 2007. Singapore, Republic of Singapore: Ministry of Health, 2009. Ministry of Health Singapore. National Health Surveillance Survey 2010. Singapore, Republic of Singapore: Ministry of Health, 2011. South Africa Department of Health, Medical Research Council, OrcMacro. South Africa Demographic and Health Survey 2003. Pretoria, South Africa: Department of Health, 2007. Phaswana-Mafuya N, Peltzer K, Schneider M, et al. Study on global AGEing and adult health (SAGE), South Africa 2007-2008. Geneva, Switzerland: World Health Organization 2012. United States of America Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey. Questionnaires, Datasets, and Related Documentation. http://www.cdc.gov/nchs/nhanes/nhanes_questionnaires.htm 3 Appendix 2: For Health Consequences Section Meta-analysis to obtain the unadjusted relative risk (RR) of dementia associated with physical inactivity The original meta-analysis by Blondell et al34 calculated the adjusted RR by comparing high vs. low physical activity levels in 26 studies. We obtained the primary papers and calculated the crude RR from 18 of these studies. An additional 4 of these studies did not provide adequate crude data, but provided an age-adjusted RR. The remaining 4 studies did not provide data from which crude or age-adjusted RRs could be obtained. We pooled the crude and age-adjusted RRs and called this the pooled unadjusted RR. We conducted a simple random effects meta-regression to account for heterogeneity across studies. The pooled unadjusted relative risk associated with physical activity was 0·63 (95% CI: 0·55–0·74). Taking the inverse to obtain the unadjusted RR for inactivity, we calculated a RR of 1·59 (95% CI: 1·35–1·82). This magnitude of risk increase was similar to that pooling only the crude RRs, which yielded 1·56 (95% CI: 1·35–1·82). Consequently, we used the unadjusted RR to include a larger number of studies and ensure a closer parallel between studies used to calculate the pooled unadjusted and adjusted RRs.30 The studies included in these calculations varied in the number and type of included adjustment factors, but those most commonly modelled were: age, sex, education, baseline cognition / mental health, physical functional capacity, genetic markers (e.g. apolipoprotein E ɛ4 allele), history of comorbidities (i.e. heart disease, stroke, diabetes, hypertension, hypercholesterolemia) and related behavioural risk factors (i.e. smoking, alcohol). For complete references to the studies shown, please refer to Blondell et al34. 4 Appendix 3: For Health Consequences Section Prevalence of physical inactivity (%) overall and among cases of dementia Study Name Location Canadian Study of Health and Aging (1991-92)a Prevalence of physical inactivity at baseline (%) Overall Cases Adjustment Factor Canada 42.02 48.42 1.15 Finland 37.48 27.27 0.73 Finland 34.72 29.55 0.85 Finland 58.83 71.70 1.22 Iceland 95.49 96.20 1.01 Italy 38.72 51.16 1.32 The Rotterdam Study (1997-1999) - leisure Netherlands 49.98 54.55 1.09 Ibadan Study of Aging (2003-04) Nigeria 30.78 42.35 1.38 International Dementia Research Program in Developing Countries (2001-03) South Korea 27.61 53.33 1.93 Caerphilly Prospective Study (1979-1983) - vocation UK 40.30 37.50 0.93 Caerphilly Prospective Study (1979-1983) - leisure UK 29.22 34.72 1.19 Honolulu Heart Program (1965-68) USA 60.66 70.89 1.17 Cardiovascular Health Cognition Study (1992)a USA 49.99 55.32 1.11 Aging, Demographics & Memory Study (2001-03)a USA 67.45 77.98 1.16 Adult Changes in Thought (1994-96) USA 23.98 32.91 1.37 Washington Heights-Inwood Columbia Aging Project (1992, 1999) USA 62.23 71.28 1.15 Cardiovascular risk factors, Aging and Incidence of Dementia (1972, 77, 82, 87) - vocation Cardiovascular risk factors, Aging and Incidence of Dementia (1972, 77, 82, 87) - transport Cardiovascular risk factors, Aging and Incidence of Dementia (1972, 77, 82, 87) Age Gene/Environment Susceptability - Reykjavik Study (1967) Conselice Study of Brain Aging (1999-2000) a a MEAN ADJUSTMENT FACTOR (SE) = 1.17 (0.07) NOTE: Physical inactivity was defined by the author of each included study. a Data was dichotomised using cut-off values that closely approximated meeting the current global physical activity recommendations. We initially only included studies that applied physical activity cut-offs closely approximating current global recommendations to calculate an adjustment factor of 1·18 (SE=0·04). However, this limited the geographical representation of studies to Canada, Italy and USA. Subsequent calculations applying physical activity level 5 classifications defined by the author of each study broadened the global representativeness of the data and yielded a more conservative adjustment factor of 1·17 (SE=0·07). Consequently, we have included all of these cohorts in our final analyses. 6 Appendix 4: For Health Consequences Section Estimated prevalence of physical inactivity and PAF's for dementia associated with physical inactivity, by country World Bank Country income (sorted by WHO region) class. (2014) Africa: Benin Burkina Faso Central African Republic Chad Comoros Congo, Dem. Rep. Eritrea Ethiopia Gambia, The Guinea Kenya Liberia Madagascar Malawi Mali Mozambique Niger Rwanda Sierra Leone Tanzania Togo Zimbabwe Cameroon Cape Verde Congo, Rep. Cote d'Ivoire Ghana Lesotho Mauritania Nigeria Sao Tome and Principe Senegal Swaziland Zambia Algeria Botswana Gabon Mauritius Namibia Seychelles South Africa Eastern Mediterranean Egypt, Arab Rep. Pakistan Iran, Islamic Rep. Prevalence of physical inactivity Population a (5.4 - 8.4) (15.9 - 20.9) (1.0 - 23.1) (-1.7 - 50.8) (13.1 - 15.4) (20.4 - 31.7) (9.1 - 12.2) (-3.6 - 41.5) (16.3 - 26.7) (0.3 - 19.5) (-3.4 - 41.8) (23.5 - 31.5) (14.9 - 21.0) (6.6 - 8.5) (-2.1 - 49.4) (3.9 - 7.8) (20.6 - 29.6) (14.0 - 16.6) (11.0 - 17.4) (5.9 - 7.8) (8.9 - 11.9) (-2.2 - 47.0) (5.4 - 56.1) (12.6 - 26.6) (-0.9 - 51.7) (-2.6 - 47.7) (13.1 - 18.1) (5.9 - 8.5) (12.7 - 77.4) (-6.6 - 51.2) (13.7 - 17.5) (-1.5 - 51.5) (5.5 - 68.1) (-3.2 - 44.2) (30.4 - 38.5) (19.0 - 35.4) (6.6 - 45.5) (-1.3 - 51.7) (1.9 - 61.6) (18.5 - 23.1) (42.7 - 51.1) People eventually developing dementiaa L L L L L L L L L L L L L L L L L L L L L L LM LM LM LM LM LM LM LM LM LM LM LM UM UM UM UM UM UM UM 6.9 18.4 12.0 24.6 14.2 26.0 10.7 18.9 21.5 9.9 19.2 27.5 17.9 7.5 23.7 5.8 25.1 15.3 14.2 6.9 10.4 22.4 30.7 19.6 25.4 22.6 15.6 7.2 45.1 22.3 15.6 25.0 36.8 20.5 34.4 27.2 26.0 25.2 31.8 20.8 46.9 8.1 (4.1 - 12.2) 21.6 (11.5 - 31.6) 14.1 (-10.1 - 38.3) 28.8 (-14.3 - 71.7) 16.6 (9.2 - 24.2) 30.5 (15.2 - 45.7) 12.5 (6.6 - 18.3) 22.1 (-12.7 - 57.0) 25.2 (12.2 - 38.0) 11.6 (-8.6 - 31.7) 22.5 (-14.6 - 59.5) 32.2 (17.1 - 47.3) 21.0 (11.0 - 31.0) 8.8 (4.7 - 12.8) 27.8 (-12.4 - 67.7) 6.8 (2.9 - 10.7) 29.4 (15.2 - 43.6) 17.9 (9.8 - 26.0) 16.6 (8.3 - 25.0) 8.1 (4.3 - 11.8) 12.2 (6.5 - 17.9) 26.2 (-13.5 - 65.9) 36.0 (-10.3 - 82.2) 23.0 (9.5 - 36.4) 29.8 (-13.3 - 72.7) 26.5 (-13.6 - 66.4) 18.3 (9.6 - 26.9) 8.4 (4.4 - 12.5) 52.8 (-1.8 - 107.2) 26.1 (-9.3 - 61.4) 18.3 (9.9 - 26.7) 29.3 (-12.1 - 70.7) 43.1 (-8.6 - 94.7) 24.0 (-13.7 - 61.7) 40.3 (21.8 - 58.8) 31.9 (14.3 - 49.3) 30.5 (-16.0 - 76.9) 29.5 (-12.7 - 71.7) 37.3 (-10.8 - 85.2) 24.4 (13.2 - 35.5) 55.0 (30.0 - 79.7) LM LM UM 32.3 (27.8 - 36.8) 37.8 (20.1 - 55.4) 26.0 (-1.4 - 53.3) 30.5 (-13.2 - 73.9) 33.5 (32.1 - 34.9) 39.3 (21.7 - 56.6) 7 Population Attributable Fraction Unadjusted 3.9 9.8 6.6 12.7 7.1 13.3 5.9 10.0 11.3 5.5 10.2 14.0 9.6 4.2 12.3 3.3 12.9 8.3 7.7 3.9 5.8 11.7 15.3 10.4 13.0 11.8 8.4 4.1 21.0 11.6 8.4 12.9 17.8 10.8 16.9 13.8 13.3 12.9 15.8 10.9 21.7 b (2.5 - 5.6) (6.5 - 13.5) (1.4 - 12.2) (1.4 - 23.1) (5.2 - 10.5) (8.8 - 18.4) (3.9 - 8.2) (0.2 - 19.7) (7.3 - 15.6) (1.0 - 10.4) (0.3 - 19.7) (9.4 - 18.7) (6.2 - 13.1) (2.8 - 5.9) (1.1 - 22.5) (2.0 - 5.0) (8.6 - 17.6) (5.5 - 11.3) (5.0 - 10.9) (2.6 - 5.5) (3.8 - 8.0) (0.8 - 21.7) (4.7 - 25.5) (6.2 - 15.0) (1.8 - 23.4) (0.8 - 22.1) (5.6 - 11.6) (2.6 - 5.7) (8.8 - 32.3) (-1.2 - 23.0) (5.7 - 11.5) (1.2 - 23.2) (5.2 - 29.2) (0.1 - 20.5) (11.5 - 22.3) (8.7 - 19.4) (5.0 - 21.9) (1.5 - 23.6) (3.5 - 27.0) (7.4 - 14.8) (15.3 - 28.0) 16.0 (11.0 - 21.4) 13.3 (2.1 - 24.3) 16.5 (11.4 - 21.7) Adjusted 1.1 3.0 1.9 4.0 2.3 4.2 1.7 3.1 3.5 1.6 3.1 4.4 2.9 1.2 3.8 0.9 4.1 2.5 2.3 1.1 1.7 3.6 5.0 3.2 4.1 3.7 2.5 1.2 7.3 3.6 2.5 4.0 5.9 3.3 5.6 4.4 4.2 4.1 5.1 3.4 7.6 b (0.3 - 2.0) (0.9 - 5.4) (-0.8 - 5.5) (-0.9 - 10.4) (0.7 - 4.1) (1.2 - 7.5) (0.5 - 3.1) (-1.0 - 8.2) (1.1 - 6.3) (-0.8 - 4.6) (-1.1 - 8.7) (1.4 - 8.0) (0.8 - 5.2) (0.4 - 2.2) (-0.7 - 9.8) (0.3 - 1.8) (1.2 - 7.3) (0.8 - 4.4) (0.7 - 4.2) (0.3 - 2.0) (0.5 - 3.0) (-0.9 - 9.5) (-0.5 - 12.0) (0.9 - 5.9) (-0.8 - 10.6) (-0.9 - 9.5) (0.8 - 4.5) (0.4 - 2.1) (0.4 - 16.0) (-0.5 - 9.1) (0.8 - 4.5) (-0.7 - 10.4) (-0.2 - 13.9) (-1.0 - 8.8) (1.7 - 10.0) (1.2 - 8.1) (-1.2 - 11.0) (-0.7 - 10.3) (-0.5 - 12.6) (1.0 - 6.0) (2.2 - 13.5) 5.2 (1.6 - 9.2) 4.2 (-0.9 - 10.9) 5.4 (1.6 - 9.6) Iraq UM Jordan UM Lebanon UM Libya UM Tunisia UM Kuwait H Qatar H Saudi Arabia H United Arab Emirates H Europe: Georgia LM Kyrgyz Republic LM Moldova LM Ukraine LM Uzbekistan LM Bosnia and Herzegovina UM Bulgaria UM Hungary UM Kazakhstan UM Romania UM Serbia UM Turkey UM Andorra H Austria H Belgium H Croatia H Cyprus H Czech Republic H Denmark H Estonia H Finland H France H Germany H Greece H Ireland H Italy H Latvia H Lithuania H Luxembourg H Malta H Netherlands H Norway H Poland H Portugal H Russian Federation H Slovak Republic H Slovenia H Spain H Sweden H United Kingdom H Latin America and Caribbean: Guatemala LM Paraguay LM Argentina UM Brazil UM 49.3 15.6 38.8 38.0 23.5 56.6 41.6 61.0 38.4 (45.4 - 53.2) (14.3 - 17.0) (33.0 - 44.6) (34.7 - 41.4) (-2.0 - 49.0) (54.3 - 58.8) (38.0 - 45.1) (57.2 - 64.8) (7.1 - 69.7) 57.8 (31.7 - 83.7) 18.3 (10.0 - 26.5) 45.5 (24.0 - 66.8) 44.5 (24.4 - 64.6) 27.5 (-12.7 - 67.7) 66.3 (36.7 - 95.6) 48.7 (26.7 - 70.6) 71.5 (39.4 - 103.3) 45.0 (-8.7 - 98.5) 22.5 8.4 18.6 18.3 12.2 25.0 19.7 26.5 18.5 (15.9 - 28.8) (5.7 - 11.5) (12.7 - 24.6) (12.8 - 23.9) (1.4 - 22.5) (18.1 - 31.7) (13.9 - 25.8) (19.2 - 33.6) (6.3 - 29.5) 8.0 2.5 6.3 6.1 3.8 9.1 6.7 9.9 6.2 (2.5 - 14.0) (0.8 - 4.5) (1.9 - 11.0) (1.9 - 10.8) (-0.8 - 9.8) (2.8 - 16.2) (2.0 - 12.0) (2.9 - 17.5) (-0.2 - 14.8) 20.6 13.3 12.3 12.2 19.2 18.1 21.0 18.1 20.6 25.3 38.7 32.8 26.1 23.8 33.2 16.2 34.7 23.8 24.3 11.9 23.5 23.8 21.1 12.9 35.1 33.2 22.0 18.4 28.5 42.9 15.5 25.8 18.7 34.9 9.5 17.8 21.3 30.5 28.7 37.3 (18.9 - 22.4) (11.6 - 15.0) (10.9 - 13.6) (-4.0 - 28.4) (16.9 - 21.5) (-3.7 - 40.0) (-3.6 - 45.5) (-4.0 - 40.1) (-3.4 - 44.6) (-2.1 - 52.8) (7.4 - 69.9) (2.9 - 62.7) (-1.4 - 53.5) (-2.1 - 49.7) (3.3 - 63.2) (-3.4 - 35.8) (4.1 - 65.3) (18.2 - 29.3) (-2.0 - 50.6) (-4.3 - 28.1) (-2.2 - 49.3) (19.8 - 27.8) (-3.5 - 45.7) (-3.9 - 29.7) (4.4 - 65.8) (2.9 - 63.4) (-3.5 - 47.5) (11.7 - 25.0) (0.0 - 57.0) (10.6 - 75.2) (-3.8 - 34.8) (-1.1 - 52.8) (-4.1 - 41.6) (4.3 - 65.6) (6.5 - 12.5) (-4.5 - 40.2) (-2.8 - 45.3) (1.0 - 59.9) (0.2 - 57.2) (35.9 - 38.8) 24.1 (13.2 - 35.0) 15.6 (8.3 - 22.7) 14.4 (7.8 - 20.9) 14.3 (-11.5 - 40.0) 22.5 (12.1 - 32.9) 21.2 (-12.2 - 54.5) 24.6 (-14.8 - 63.9) 21.2 (-13.7 - 56.0) 24.1 (-14.0 - 62.1) 29.6 (-14.2 - 73.5) 45.3 (-6.0 - 96.5) 38.4 (-9.8 - 86.6) 30.6 (-4.1 - 65.1) 27.9 (-13.8 - 69.5) 38.9 (-9.4 - 87.2) 19.0 (-12.8 - 50.7) 40.7 (-9.9 - 91.1) 27.9 (13.7 - 42.0) 28.5 (-14.2 - 71.0) 13.9 (-11 - 38.9) 27.5 (-14.2 - 69.2) 27.9 (14.5 - 41.1) 24.7 (-14.8 - 64.2) 15.1 (-11.5 - 41.8) 41.1 (-9.7 - 91.8) 38.9 (-11 - 88.6) 25.8 (-14.9 - 66.3) 21.6 (8.7 - 34.3) 33.4 (-13.2 - 79.9) 50.3 (-4.3 - 104.7) 18.2 (-13.1 - 49.4) 30.2 (-13.4 - 73.8) 21.9 (-13.8 - 57.6) 40.9 (-9.9 - 91.6) 11.1 (4.9 - 17.4) 20.9 (-12.0 - 53.7) 25.0 (-15.1 - 64.9) 35.7 (-11.7 - 83.0) 33.6 (-12.9 - 80.1) 43.7 (24.3 - 63.1) 10.8 7.3 6.8 6.7 10.2 9.6 11.0 9.6 10.8 13.0 18.6 16.2 13.3 12.3 16.4 8.7 17.0 12.3 12.5 6.6 12.2 12.3 11.1 7.1 17.2 16.4 11.5 9.8 14.4 20.2 8.4 13.2 9.9 17.1 5.3 9.5 11.2 15.3 14.5 18.0 (7.3 - 14.6) (4.8 - 10.0) (4.5 - 9.3) (-0.6 - 14.2) (6.8 - 13.9) (-0.2 - 19.0) (-0.1 - 21.2) (-0.4 - 19.1) (0.4 - 20.8) (1.4 - 23.9) (6.3 - 29.7) (4.0 - 27.3) (1.7 - 24.0) (0.8 - 22.9) (4.3 - 27.3) (-0.2 - 17.4) (4.8 - 28.4) (7.9 - 17.0) (1.3 - 23.1) (-1.0 - 14.2) (1.0 - 22.3) (8.2 - 16.7) (0.2 - 21.1) (-0.6 - 14.5) (4.8 - 28.2) (4.1 - 27.2) (0.1 - 21.8) (5.7 - 14.3) (2.8 - 25.4) (7.9 - 31.6) (-0.5 - 17.1) (1.8 - 23.7) (-0.4 - 19.6) (5.2 - 28.4) (3.2 - 7.8) (-0.7 - 18.8) (0.6 - 21.2) (3.0 - 26.5) (2.3 - 25.5) (12.6 - 23.4) 3.3 2.1 2.0 2.0 3.1 2.9 3.4 2.9 3.3 4.1 6.3 5.3 4.2 3.8 5.4 2.6 5.6 3.8 3.9 1.9 3.8 3.8 3.4 2.1 5.7 5.4 3.6 3.0 4.6 6.9 2.5 4.2 3.0 5.6 1.5 2.9 3.4 4.9 4.6 6.0 (1.0 - 5.9) (0.7 - 3.8) (0.6 - 3.5) (-1.0 - 5.6) (1.0 - 5.5) (-0.9 - 7.8) (-1.0 - 9.1) (-1.1 - 7.9) (-1.0 - 9.1) (-0.8 - 10.8) (0.1 - 14.3) (-0.4 - 12.7) (0.0 - 9.8) (-1.0 - 10.1) (-0.3 - 12.9) (-1.0 - 7.2) (-0.3 - 13.6) (1.1 - 7.1) (-0.9 - 10.4) (-0.9 - 5.6) (-1.0 - 10.0) (1.1 - 6.9) (-1.0 - 9.2) (-0.9 - 6.0) (-0.2 - 13.4) (-0.4 - 12.9) (-1.1 - 9.6) (0.8 - 5.6) (-0.8 - 11.5) (0.3 - 15.8) (-1.1 - 6.9) (-0.8 - 10.6) (-1.1 - 8.2) (-0.4 - 13.7) (0.4 - 2.9) (-0.9 - 7.8) (-1.1 - 9.4) (-0.6 - 12.4) (-0.6 - 11.7) (1.8 - 10.7) 7.3 12.7 18.8 14.4 (-0.7 - 15.5) (1.4 - 23.2) (6.6 - 30.2) (2.4 - 24.9) 2.1 4.0 6.3 4.5 (-1.0 - 6.2) (-0.9 - 10.3) (0.0 - 14.6) (-0.6 - 11.2) 13.3 (-4.7 - 31.2) 15.6 (-13.2 - 44.3) 24.6 (-1.9 - 51.1) 28.8 (-13.7 - 71.2) 39.2 (7.6 - 70.8) 45.9 (-5.9 - 97.7) 27.8 (-0.2 - 55.7) 32.6 (-12.2 - 77.2) 8 Colombia Dominica Dominican Republic Ecuador Grenada Jamaica Mexico Saint Lucia Bahamas, The Barbados Chile Saint Kitts and Nevis Trinidad and Tobago Uruguay North America: Canada United States South-East Asia: Bangladesh Myanmar Nepal Bhutan India Indonesia Sri Lanka Maldives Thailand Western Pacific: Cambodia Kiribati Lao PDR Micronesia, Fed. Sts. Mongolia c Nauru c Niue Papua New Guinea Philippines Samoa Solomon Islands Vanuatu Vietnam China c Cook Islands Fiji Malaysia Marshall Islands Tonga Australia Japan New Zealand Republic of Korea Singapore UM UM UM UM UM UM UM UM H H H H H H H H 63.6 21.8 35.9 25.2 30.5 27.9 26.0 41.2 43.0 37.6 21.3 32.4 41.5 31.7 (58.4 - 68.8) (18.8 - 24.7) (5.0 - 66.8) (-1.6 - 52.0) (26.3 - 34.8) (-0.5 - 56.3) (20.2 - 31.9) (36.0 - 46.3) (36.4 - 49.5) (33.5 - 41.7) (18.3 - 24.3) (25.8 - 39.2) (38.6 - 44.4) (26.0 - 37.5) 74.5 (40.9 - 108.0) 25.5 (13.6 - 37.3) 42.1 (-8.5 - 92.5) 29.5 (-13.6 - 72.6) 35.7 (19.0 - 52.4) 32.7 (-12.9 - 78.2) 30.5 (15.1 - 45.8) 48.3 (25.9 - 70.5) 50.4 (26.5 - 74.0) 44.1 (23.9 - 64.1) 25.0 (13.3 - 36.6) 38.0 (19.1 - 56.7) 48.6 (26.8 - 70.4) 37.1 (19.2 - 55.1) 27.3 11.4 17.5 12.9 15.3 14.1 13.3 19.6 20.2 18.2 11.2 16.0 19.7 15.8 (19.7 - 34.6) 10.3 (3.2 - 18.1) (7.6 - 15.4) 3.5 (1.0 - 6.3) (5.3 - 28.7) 5.8 (-0.3 - 13.6) (1.4 - 23.5) 4.1 (-0.9 - 10.5) (10.3 - 20.3) 4.9 (1.5 - 8.8) (2.5 - 25.1) 4.5 (-0.7 - 11.5) (8.7 - 18.1) 4.2 (1.2 - 7.5) (13.7 - 25.6) 6.7 (1.5 - 9.3) (13.8 - 26.5) 6.9 (2.0 - 12.6) (12.5 - 23.7) 6.1 (1.8 - 10.8) (7.4 - 15.1) 3.4 (1.1 - 6.1) (10.7 - 21.7) 5.2 (2.0 - 12.1) (13.8 - 25.6) 6.7 (2.1 - 11.8) (10.7 - 21.2) 5.1 (1.5 - 9.2) 23.2 (-2.2 - 48.7) 27.2 (-13.8 - 68.2) 32.4 (29.8 - 34.9) 38.0 (20.8 - 54.9) 12.0 (0.8 - 22.4) 16.0 (11.0 - 21.2) 3.7 (-0.8 - 9.8) 5.2 (1.5 - 9.3) L L L LM LM LM LM UM UM 26.8 9.9 4.1 8.7 13.4 23.7 23.8 30.7 14.8 (25.8 - 27.7) (8.2 - 11.7) (3.7 - 4.6) (7.4 - 10.1) (12.1 - 14.7) (18.7 - 28.8) (21.8 - 25.8) (6.6 - 54.7) (13.5 - 16.1) 31.4 (17.4 - 45.3) 11.6 (6.0 - 17.2) 4.8 (2.6 - 7.1) 10.2 (5.4 - 15.0) 15.7 (8.6 - 22.8) 27.8 (13.9 - 41.6) 27.9 (15.3 - 40.4) 36.0 (-15.0 - 86.7) 17.3 (9.5 - 25.1) 13.7 5.5 2.4 4.9 7.3 12.3 12.3 15.3 8.0 4.3 1.6 0.7 1.4 2.2 3.8 3.8 5.0 2.4 L LM LM LM LM LM LM LM LM LM LM LM LM UM UM UM UM UM UM H H H H H 10.3 41.1 10.3 36.0 21.4 40.7 5.6 14.7 15.8 16.2 35.1 8.4 23.9 24.1 65.0 17.0 52.3 44.5 21.6 23.8 33.8 39.8 33.4 33.1 (9.3 - 11.4) (34.4 - 47.8) (8.6 - 12.0) (32.9 - 39.1) (18.4 - 24.4) (38.2 - 43.2) (4.0 - 7.3) (13.0 - 16.4) (-4.4 - 36.1) (13.9 - 18.5) (30.2 - 39.9) (7.4 - 9.3) (15.8 - 32.1) (21.7 - 26.5) (60.5 - 69.5) (14.6 - 19.3) (47.1 - 57.6) (39.4 - 49.7) (19.3 - 23.9) (-2.4 - 50.0) (3.5 - 64.1) (37.5 - 42.0) (3.0 - 63.8) (30.7 - 35.5) 12.1 (6.6 - 17.6) 48.2 (25.2 - 71.0) 12.1 (6.3 - 17.8) 42.2 (23.1 - 61.2) 25.1 (13.3 - 36.7) 47.7 (26.3 - 68.9) 6.6 (3.0 - 10.2) 17.2 (9.3 - 25.0) 18.5 (-13.6 - 50.7) 19.0 (10.1 - 27.9) 41.1 (21.9 - 60.2) 9.8 (5.3 - 14.3) 28.0 (11.8 - 44.2) 28.2 (15.3 - 41.0) 76.2 (41.9 - 110.2) 19.9 (10.6 - 29.1) 61.3 (33.3 - 89.1) 52.1 (28.1 - 76.0) 25.3 (13.8 - 36.9) 27.9 (-13.6 - 69.3) 39.6 (-8.6 - 87.8) 46.6 (25.7 - 67.3) 39.1 (-10.6 - 88.7) 38.8 (21.3 - 56.1) 5.7 19.5 5.7 17.5 11.2 19.4 3.2 8.0 8.5 8.7 17.2 4.7 12.4 12.5 27.7 9.1 23.6 20.8 11.3 12.3 16.6 19.0 16.5 16.3 (9.3 - 18.0) (3.6 - 7.7) (1.5 - 3.3) (3.2 - 6.8) (4.8 - 10.0) (8.0 - 17.0) (8.4 - 16.6) (5.2 - 24.9) (5.3 - 11.0) (3.8 - 7.9) 1.7 (0.5 - 2.9) (13.3 - 25.8) 6.6 (2.0 - 12.0) (3.8 - 8.0) 1.7 (0.5 - 3.0) (12.2 - 23.1) 5.8 (1.7 - 10.3) (7.5 - 15.2) 3.5 (1.0 - 6.2) (13.5 - 25.2) 6.6 (2.0 - 11.7) (1.9 - 4.8) 0.9 (0.3 - 1.7) (5.3 - 10.9) 2.4 (0.7 - 4.2) (-0.9 - 17.3) 2.6 (-1.1 - 7.1) (5.8 - 12.1) 2.6 (0.8 - 4.7) (11.8 - 22.7) 5.7 (1.7 - 10.3) (3.1 - 6.6) 1.4 (0.4 - 2.4) (7.6 - 17.6) 3.9 (1.0 - 7.2) (8.5 - 16.7) 3.9 (1.2 - 7.0) (19.9 - 34.9) 10.5 (3.2 - 18.4) (6.1 - 12.4) 2.7 (0.8 - 4.9) (16.6 - 30.2) 8.5 (2.6 - 14.9) (14.5 - 27.1) 7.2 (2.2 - 12.8) (7.7 - 15.2) 3.5 (1.1 - 6.2) (1.1 - 23.1) 3.8 (-0.9 - 10.0) (4.1 - 27.9) 5.5 (-0.2 - 12.9) (13.2 - 24.8) 6.4 (2.0 - 11.4) (4.2 - 27.6) 5.4 (-0.3 - 13.2) (11.3 - 21.5) 5.3 (1.6 - 9.5) NOTE: Physical inactivity was defined as insuffient physical activity to meet present recommendations L = low income. LM = lower-middle income. UM = upper-middle income. H = high income. a c Prevalence (95% confidence interval). b Population attributable fraction (95% confidence interval). Income classification not provided by World Bank (classified according to GDP relative to other countries on World Bank list) 9 (1.3 - 7.7) (0.5 - 2.9) (0.2 - 1.2) (0.4 - 2.5) (0.7 - 3.9) (1.1 - 7.0) (1.2 - 6.9) (-0.8 - 12.7) (0.7 - 4.2) Appendix 5: Search Formula for Correlates/Determinants Section Search Formula: <A by title > and <B by title/abstract > and <C by title/abstract > • A: Physical activity key words – • B: Correlates/determinants key words – • physical activity OR physically active OR physical inactivity OR physically inactive OR exercis* OR sport* OR walk OR walking OR sedentary OR sitting OR television OR TV OR active transport* OR commut* OR bicycle OR bicycling OR bike OR biking OR active living correlate OR correlates OR determinant OR determinants OR attribute OR attributes OR factor OR factors OR psychological OR psychosocial OR self-efficacy OR social support OR attitude OR attitudes OR barrier OR barriers OR motivation* OR enjoy* OR walkability OR stage of change OR transtheoretical OR planned behaviour OR planned behavior OR learning theory OR built environment OR built environmental OR perceived environment OR perceived environments OR environmental perception OR environmental perceptions OR physical environment OR physical environments OR objective environment OR objective environments OR neighbourhood environment OR neighbourhood environments OR neighborhood environment OR neighborhood environments OR community environment OR community environments OR residential environment OR residential environments OR exercise facility OR exercise facilities OR sports facility OR sports facilities OR physical activity facility OR physical activity facilities OR sports club OR sports clubs OR park OR parks OR trail OR trails OR open space OR open spaces OR work environment OR work environments OR working environment OR working environments OR worksite environment OR worksite environments OR occupational environment OR occupational environments OR school environment OR school environments OR socio-economic status OR social class OR ses OR income OR social capital C: Low to middle income countries key words – Angola OR Albania OR Algeria OR Samoa OR Argentina OR Azerbaijan OR Belarus OR Belize OR Bosnia OR Herzegovina OR Botswana OR Brazil OR Bulgaria OR China OR Colombia OR Rica OR Cuba OR Dominica OR Dominican OR Ecuador OR Fiji OR Gabon OR Grenada OR Hungary OR Iran OR Iraq OR Jamaica OR Jordan OR Kazakhstan OR Lebanon OR Libya OR Macedonia OR Malaysia OR Maldives OR Marshall OR Mauritius OR Mexico OR Montenegro OR Namibia OR Palau OR Panama OR Peru OR Romania OR Serbia OR Seychelles OR South Africa OR Lucia OR Vincent OR Grenadines OR Suriname OR Thailand OR Tonga OR Tunisia OR Turkey OR Turkmenistan OR Tuvalu OR Venezuela OR Armenia OR Bhutan OR Bolivia OR Cameroon OR Cabo OR Congo OR Côte OR d'Ivoire OR Djibouti OR Egypt OR Salvador OR Georgia OR Ghana OR Guatemala OR Guyana OR Honduras OR Indonesia OR India OR Kiribati OR Kosovo OR Kyrgyz OR Lao OR Lesotho OR Mauritania OR Micronesia OR Moldova OR Mongolia OR Morocco OR Nicaragua OR Nigeria OR Pakistan OR Papua OR Guinea OR Paraguay OR Philippines OR Samoa OR Tomé OR Senegal OR Solomon OR Sudan OR Lanka OR Sudan OR Swaziland OR Syrian OR Timor OR Leste OR Ukraine OR Uzbekistan OR Vanuatu OR Vietnam OR Gaza OR Yemen OR Zambia OR Afghanistan OR Bangladesh OR Benin OR Burkina OR Burundi OR Cambodia OR Central African OR Chad OR Comoros OR Congo OR Eritrea OR Ethiopia OR Gambia OR Guinea OR Guinea OR Bissau OR Haiti OR 10 Kenya OR Korea OR Liberia OR Madagascar OR Malawi OR Mali OR Mozambique OR Myanmar OR Nepal OR Niger OR Rwanda OR Sierra OR Leone OR Somalia OR Tajikistan OR Tanzania OR Togo OR Uganda OR Zimbabwe OR Angolan OR Angolese OR Albanian OR Skipetar OR Algerian OR Algerine OR American Samoan OR Argentine OR Argentinian OR Argentino OR Azerbaijani OR Belarusian OR Belarussian OR Belizean OR Bosnian, Herzegovinian OR Botswanian OR Motswana OR Batswana OR Brazilian OR Bulgar OR Bulgarian OR Chinese OR Colombian OR Costa Rican OR Cuban OR Dominican OR Dominican OR Ecuadorian OR Fijian OR Gabonese OR Grenadian OR Hungarian OR Iranian OR Persian OR Irani OR Iraqi OR Jamaican OR Jordanian OR Kazakhstani OR Lebanese OR Libyan OR Macedonian OR Malaysian OR Maldivian OR Marshallese OR Mauritian OR Mexican OR Montenegrin OR Namibian OR Palauan OR Panaman OR Panamanian OR Peruvian OR Romanian OR Serb OR Serbian OR Seychellois OR South African OR Saint Lucian OR Vincentian OR Saint Vincentian OR Surinamer OR Surinamese OR Thai OR Tongan OR Tunisian OR Turkish OR Turk OR Turkmen OR Tuvaluan OR Venezuelan OR Armenian OR Bhutanese OR Bolivian OR Cameroonian OR Cabo Verdean OR Congolese OR Ivorian OR Djiboutian OR Egyptian OR Salvadoran OR Georgian OR Ghanaian OR Guatemalan OR Guyanese OR Honduran OR Indonesian OR Indian OR I-Kiribati OR Kosovar OR Kyrgyz OR Kyrgyzstani OR Lao OR Laotian OR Mosotho OR Basotho OR Mauritanian OR Micronesian OR Moldovan OR Mongolian OR Moroccan OR Nicaraguan OR Nigerian OR Pakistani OR Papua New Guinean OR Paraguayan OR Filipino OR Samoan OR Sao Tomean OR Senegalese OR Solomon Islander OR South Sudanese OR Sri Lankan OR Sudanese OR Swazi OR Syrian OR Timorese OR Ukrainian OR Uzbekistani OR Ni-Vanuatu OR Vietnamese OR Yemeni OR Zambian OR Afghan OR Bangladeshi OR Beninese OR Burkinabe OR Burundian OR Cambodian OR Central African OR Chadian OR Comoran OR Congolese OR Eritrean OR Ethiopian OR Gambian OR Guinean OR Bissau-Guinean OR Haitian OR Kenyan OR North Korean OR Liberian OR Malagasy OR Malawian OR Malian OR Mozambican OR Burmese OR Nepali OR Nigerien OR Rwandan OR Sierra Leonean OR Somali OR Tajikistani OR Tanzanian OR Togolese OR Ugandan OR Zimbabwean Appendix 6: Inclusion Criteria for Correlate/Determinants Section 1. Publication after January of 1999 to March of 2015 2. Publication from LMICs. Studies for which the sample include LMICs but not have been analyzed country specific results were not included. Classification of income level of countries was based on the World Bank classification 3. Studies which main focus was on physical activity (including sedentary behavior) 4. Physical activity was supposed to be outcome, dependent variables. We did not include paper which examined correlates/determinants of physical fitness. 5. Correlates/determinants means sociodemographic, biological, psychological, behavioral, social, and environmental factors those were examined as independent variables We did not include studies which examined the association of PA as independent variables with obesity and cardiovascular risk factors as dependent variables. 11 6. Intervention studies which analyzed intervention effects on mediators and the relation of mediator change to PA change. 7. We did not include qualitative research. 8. No language limitation (currently) 9. All age groups (children:5-12, adolescents:12-18, adults:18-64, older adults:65-) 10. Publications which examined healthy people, we did not include patients. We included papers using obese population. Appendix 7: Flow of Systematic Search for Correlates/Determinants Section 1383 articles identified through systematic search 937 articles excluded through title screening 446 abstracts for screening 230 articles excluded through abstract screening 216 of text articles assessed for eligibility 18 of full text articles excluded, not correlates/determinants studies not low to middle income countries 198 text for reading Appendix 8: Criteria for Judgment of Directions of Association of Correlates/Determinants with Physical Activity 1. Categories are ++, repeatedly documented positive association with physical activity; +, weak or mixed evidence of positive association with physical activity; 00, repeatedly documented lack of association with physical activity; 0, weak or mixed evidence of no association with physical activity; --, repeatedly documented negative association with physical activity; -, weak or mixed evidence of negative association with physical activity. 2. If the dominant categories occupy two thirds or more, judgements are “++”, ”00”, or ”--”. 3. If the dominant categories occupy less than two thirds, judgements are “+”, ”0”, or ”-”. 12 4. If there are two first categories (same in scores), judgement will be conservative, that is “0”. 5. Blank spaces indicate not enough data available (less than 5 papers examined the correlates/determinants). Appendix 9: References for Correlates/Determinants Section 1. Ying Z, Ning LD, Xin L. Relationship Between Built Environment, Physical Activity, Adiposity, and Health in Adults Aged 46-80 in Shanghai, China. Journal of physical activity & health 2015; 12(4): 569-78. 2. Souza AM, Fillenbaum GG, Blay SL. Prevalence and correlates of physical inactivity among older adults in Rio Grande do Sul, Brazil. PloS one 2015; 10(2): e0117060. 3. Salvo D, Reis RS, Hino AA, Hallal PC, Pratt M. Intensity-specific leisure-time physical activity and the built environment among Brazilian adults: a best-fit model. Journal of physical activity & health 2015; 12(3): 30718. 4. Olaya Contreras P, Bastidas M, Arvidsson D. Colombian Children With Overweight and Obesity Need Additional Motivational Support at School to Perform Health-Enhancing Physical Activity. Journal of physical activity & health 2015; 12(5): 604-9. 5. Meneguci J, Sasaki JE, da Silva Santos A, Scatena LM, Damiao R. Socio-demographic, clinical and health behavior correlates of sitting time in older adults. BMC public health 2015; 15: 65. 6. Mendonca G, Junior JC. Physical activity and social support in adolescents: analysis of different types and sources of social support. Journal of sports sciences 2015; 33(18): 1942-51. 7. Kaur J, Kaur G, Ho BK, Yao WK, Salleh M, Lim KH. Predictors of physical inactivity among elderly malaysians: recommendations for policy planning. Asia-Pacific journal of public health / Asia-Pacific Academic Consortium for Public Health 2015; 27(3): 314-22. 8. Glozah FN, Pevalin DJ. Perceived social support and parental education as determinants of adolescents' physical activity and eating behaviour: a cross-sectional survey. International journal of adolescent medicine and health 2015; 27(3): 253-9. 9. Zhang M, Chen X, Wang Z, Wang L, Jiang Y. [Leisure-time physical exercise and sedentary behavior among Chinese elderly, in 2010]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2014; 35(3): 242-5. 10. Zhang F, Gao W, Yu C, et al. [A twin study in Qingdao and Lishui: heritability of exercise participation and sedentary behavior]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2014; 35(6): 630-4. 11. Ying C, Kuay LK, Huey TC, et al. Prevalence and factors associated with physical inactivity among Malaysian adults. The Southeast Asian journal of tropical medicine and public health 2014; 45(2): 467-80. 13 12. Vaidya A, Krettek A. Physical activity level and its sociodemographic correlates in a peri-urban Nepalese population: a cross-sectional study from the Jhaukhel-Duwakot health demographic surveillance site. The international journal of behavioral nutrition and physical activity 2014; 11(1): 39. 13. Teh CH, Lim KK, Chan YY, et al. The prevalence of physical activity and its associated factors among Malaysian adults: findings from the National Health and Morbidity Survey 2011. Public health 2014; 128(5): 416-23. 14. Tam CL, Bonn G, Yeoh SH, Wong CP. Investigating diet and physical activity in Malaysia: education and family history of diabetes relate to lower levels of physical activity. Frontiers in psychology 2014; 5: 1328. 15. Su M, Tan YY, Liu QM, et al. Association between perceived urban built environment attributes and leisuretime physical activity among adults in Hangzhou, China. Preventive medicine 2014; 66: 60-4. 16. Silva RJ, Silva DA, Oliveira AC. Low physical activity levels and associated factors in Brazilian adolescents from public high schools. Journal of physical activity & health 2014; 11(7): 1438-45. 17. Silva KS, da Silva Lopes A, Dumith SC, Garcia LM, Bezerra J, Nahas MV. Changes in television viewing and computers/videogames use among high school students in Southern Brazil between 2001 and 2011. International journal of public health 2014; 59(1): 77-86. 18. Silva DA, Tremblay MS, Goncalves EC, Silva RJ. Television time among Brazilian adolescents: correlated factors are different between boys and girls. TheScientificWorldJournal 2014; 2014: 794539. 19. Salvo D, Reis RS, Stein AD, Rivera J, Martorell R, Pratt M. Characteristics of the built environment in relation to objectively measured physical activity among Mexican adults, 2011. Preventing chronic disease 2014; 11: E147. 20. Salahshuri A, Sharifirad G, Hassanzadeh A, Mostafavi F. Physical activity patterns and its influencing factors among high school students of Izeh city: Application of some constructs of health belief model. Journal of education and health promotion 2014; 3: 25. 21. Romeiro-Lopes TC, Franca-Gravena AA, Dell Agnolo CM, Rocha-Brischiliari SC, De Barros Carvalho MD, Pelloso SM. [The factors associated with physical inactivity in a city in southern Brazil]. Revista de salud publica (Bogota, Colombia) 2014; 16(1): 40-52. 22. Reyes Fernandez B, Montenegro Montenegro E, Knoll N, Schwarzer R. Self-efficacy, action control, and social support explain physical activity changes among Costa Rican older adults. 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Psychosocial aspects of Costa Rican adolescents' eating and physical activity patterns. The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2002; 31(2): 212-9. 26 Appendix 10: Characteristics of Articles on Physical Activity Correlates/Determinants from 1999 to 2015 February Total (1999-2015 Feb) No % Number of publications Number of publications per year Number of countries* 1999-2011 No % 2012-2015 Feb No 197 93 104 12·2 7·2 32·8 31 22 23 % Country of publication · Brazil(102) 51·8 Brazil(47) 50·5 Brazil(55) 52·9 China(17) 8·6 China(8) 8·6 China(9) 8·7 Malaysia(10) 5·1 Colombia(4) 4·3 Malaysia(7) 6·7 Iran(7) 3·6 Mexico(4) 4·3 Iran(5) 4·8 Colombia(6) 3·0 Malaysia(3) 3·2 Nigeria(3) 2·9 Mexico(6) 3·0 Colombia(2) 1·9 3·0 Nigeria(3) Vietnam(3) 3·2 Nigeria(6) 3·2 India(2) 1·9 Vietnam(5) 2·5 Iran(2) 2·2 Mexico(2) 1·9 Thailand(4) 2·0 Pakistan(2) 2·2 Nepal(2) 1·9 Costa Rica(2) 1·0 Thailand(2) 2·2 Thailand(2) 1·9 Egypt(2) 1·0 Albania(1) 1·1 Vietnam(2) 1·9 Ghana(2) 1·0 Chinese Taipei(1) 1·1 South-Africa(2) 1·9 India(2) 1·0 Costa Rica(1) 1·1 Argentina(1) 1·0 Lebanon(2) 1·0 Egypt(1) 1·1 Costa Rica(1) 1·0 Nepal(2) 1·0 Ghana(1) 1·1 Egypt(1) 1·0 Pakistan(2) 1·0 Hungary(1) 1·1 Ghana(1) 1·0 Peru(2) 1·0 Jamaica(1) 1·1 Kenya(1) 1·0 South Africa(2) 1·0 Jordan(1) 1·1 Lebanon(1) 1·0 Albania(1) 0·5 Lebanon(1) 1·1 Libya(1) 1·0 Argentina(1) 0·5 Morocco(1) 1·1 Mozambique(1) 1·0 Chinese Taipei(1) 0·5 Peru(1) 1·1 Peru(1) 1·0 Hungary(1) 0·5 Turkey(1) 1·1 Sri Lanka(1) 1·0 Jamaica(1) 0·5 Collaborative studies(3) 3·2 Ukraine(1) 1·0 Jordan(1) 0·5 Kenya(1) 0·5 27 Libya(1) 0·5 Morocco(1) 0·5 Mozambique(1) 0·5 Sri Lanka(1) 0·5 Turkey(1) 0·5 Ukraine(1) 0·5 Collaborative studies(3) 1·5 Upper middle income 168 85·3 79 84·9 89 85·6 Lower middle income 22 11·2 11 11·8 11 10·6 Low income 4 2·0 0 0·0 4 3·8 Collaborative studies 3 1·5 3 3·2 - - Income level of countries** Age group Children/Adolescents 73 37·1 29 31·2 44 42·3 124 62·9 64 68·8 60 57·7 Male 4 2·0 2 2·2 2 1·9 Female 9 4·6 6 6·5 3 2·9 184 93·4 85 91·4 99 95·2 26 13·2 8 8·6 18 17·3 Adults/Elderly Gender Both Population (multiple choice) National Local governmental 117 59·4 57 61·3 60 57·7 Community 13 6·6 8 8·6 5 4·8 Worksite 10 5·1 5 5·4 5 4·8 School 50 25·4 16 17·2 34 32·7 Others 5 2·5 3 3·2 2 1·9 148 75·1 74 79·6 74 71·2 49 24·9 19 20·4 30 28·8 Sampling strategy Random Nonrandom/Unclear 28 Response rate Available Not available/Unclear 117 59·4 61 65·6 56 53·8 80 40·6 32 34·4 48 46·2 Study design Cross-sectional 189 95·9 91 97·8 98 94·2 Longitudinal 8 4·1 2 2·2 6 5·8 Intervention 0 0·0 0 0·0 0 0·0 PA (multiple choice) Total PA 111 56·3 51 54·8 60 57·7 Leisure PA/Exercise 79 40·1 37 39·8 42 40·4 Work-related PA 12 6·1 5 5·4 7 6·7 Transport PA (walking/cycling) 45 22·8 19 20·4 26 25·0 Domestic/household PA 11 5·6 5 5·4 6 5·8 Others (e·g sedentray) 32 16·2 18 19·4 14 13·5 Self-report/Interview PA measure 183 92·9 90 96·8 93 89·4 Objective method 8 4·1 1 1·1 7 6·7 Both 5 2·5 2 2·2 3 2·9 129 65·5 55 59·1 74 71·2 68 34·5 38 40·9 30 28·8 Dem & Biol 160 81·2 77 82·8 83 79·8 Psych & cog 55 27·9 23 24·7 32 30·8 Behav 67 34·0 36 38·7 31 29·8 Social 40 20·3 15 16·1 25 24·0 Enviorn 87 44·2 39 41·9 48 46·2 Reliability and/or validity of PA measure Examined/cited Unexamined and Original Correlates/determinants (multiple choice) Reliability and/or validity of correlates measure 29 Examined/cited 76 38·6 33 35·5 43 41·3 Unexamined and Original 121 61·4 60 64·5 61 58·7 Multiple variate 187 94·9 91 97·8 96 92·3 Univariate only 10 5·1 2 2·2 8 7·7 Analyses *: Countries which conducted only collaborative studies were not included **: Classification of income level of countries was based on the World Bank classification 30 Appendix 11: Summary of Physical Activity Intervention Studies Reviewed Summary of Studies Included by Intervention Domain/Strategy Campaigns and Informational Behavioral and Social Policy and Approaches/Community-wide Environmental/Community-wide Campaigns Policies and Planning 5 9 1 Iran, China, South Africa, India, Vanatu, India, South Africa, Chile, Colombia Indonesia, Vietnam Brazil, China, Pakistan 80 (4/5) 56 (5/9) 100 (1/1) Number of studies included Countries represented % (#) of studies with some evidence Characteristics of Studies Included by Intervention Domain/Strategy Stud Study Intervention Sample Author Study y Country strategy population/setting Effect size (year) period desi description measure gn Campaigns and Informational Approaches/Community-wide Campaigns Rabiei 2000– QE1 Iran Education – Adult residents of 3 Baseline ∆ LTPA (2010)51 2006 public media and communities in N=6000 and campaigns for central Iran (Interventi Transport entire population (intervention areas: on/ ation PA and specific 1 urban, 1 rural; reference target groups; reference area: 1 n not Environment – urban/rural) reported) urban environment modifications to reduce personal vehicle use and promote active transportation (e.g., cycling) Policy – adding exercise time in the afternoon shift of schools Lv (2014)52 2008– 2011 QE1 China Community mobilization, structural change, health education, social marketing Adult residents of 3 adjacent districts of Hangzhou, China (2 intervention; 1 reference area) Baseline I= 1016 R= 1000 ∆ reported total PA (walking, moderate PA, and vigorous PA) Krishnan (2011)55 2003– 2008 CS3 India and Indonesi a Media; environmental change; health messages Adult residents of 2 selected sites: 1 in India and 1in Indonesia Baseline India N = 5143 Indonesia N = 1806 Work, leisuretime, and transporta tion PA 31 Results Value used in summary Followup time ∆ LTPA (METmin/d), 2001 vs. 2000 Women I = +13·4*; R = +6·5* Men I = +7·3***; R = -10·9 2 years ∆ Transportation PA (METmin/d), 2001 vs. 2000 Women I = -3·3; R = 30·9* Men I = -12·4; R = 46·7* ∆ PA (METmin/wk) I – sig ∆ in low levels of PA, no ∆ in R sites Sig ∆ in mod PA and vig PA in I and decrease in R sites Total PA net ∆ of +5% in I sites vs. R sites ∆ Inactivity (%) India Men: -3·0; Women: +18·3*** Indonesia Men: -3·9; Women: 19·2*** 2 years 3 years QE1 Viet Nam Media; health messages; community support Adult residents of two rural communes (1 intervention; 1 reference) I = 2,298 R = 2352 Work, leisuretime, and transporta tion PA ∆ Physical inactivity (%) I vs. R +6·1 net effect – (I site underwent rapid urban change vs. R community) 3 years Behavioral and Social Siefken 2011 (2015)58 CS3 Vanatu Health messages; walking campaign Female civil servants at one worksite N = 207 Pedomete r measured steps over 12 weeks 12 weeks Kain (2014) RT4 Chile Classroom nutrition education; increase physical education (PE) class time; increase time in moderate activity during PE classes 6-8 y/o low-income students attending primary school in Santiago – exposed or not exposed to intervention I = 651 C = 823 ∆ PE class time Net increase in steps – pre-post = +26% among all subjects Net steps low risk (n = 101) +82%; high risk (n = 24), 228% ∆ PE class time (min) I – +9·1 C – +3·4 Nguyen (2012)54 2006– 2009 2011– 2012 Balagopal (2012)56 2007– 2008 CS3 India Community Health Worker (CHW)delivered health education; social support Adult residents of selected rural community; low and high SES N = 1638 Skaal (2012)57 2008 QE1 South Africa Social support; media; PA challenge Hospital employees (medical and nonmedical) Medical n = 100; Nonmedical n = 100 Vio (2011)61 2006 QE1 Chile PA classes led by trained instructors 3x/week for 6 months N = 331 GrA = 82 GrB = 80 GrC = 84 GrD = 85 Parra (2010)59 2007 CS3 Brazil PA classes Low SES women residing in selected community 4 groups – GrAPA; GrB - Diet only; GrC- PA; GrD- Control Community 32 32,974 ∆ class time in MVPA as measured by pedomete r Work PA; househol d chores; brisk walking; vigorous or manual PA; transport ation PA; leisuretime PA Selfreport stage of physical activity based on Transtheoretica l Model (TTM) PA class adherenc e PA 1 year ∆ Class time in MVPA (%) I – -1·1 C – -8·3* ∆ MVPA (%): +11·6** among normal fasting blood glucose participants; +14·2** among glucose intolerant; +4·2*** among T2DM participants 6 months TTM mean stages Pre-test = 2·64 Post-test = 3·74*** 6 months Mean PA class adherence: GrA: 49·8%; GrC37·5% 6 months People using 5 years (Academia da Cidade - ACP) in public parks led by PA instructors residents of Recife who visited both ACP and Non-ACP Parks Mendonca (2010)60 2008 CS3 Brazil PA classes (Academia da Cidade - ACP) in public parks led by PA instructors Adult residents of selected community Li (2011)62 2009 QE1 China Classroom-based PA sessions: 2 daily 10-min PA sessions in between class breaks (Happy10 program) 8-11 y/o students attending primary schools in Beijingexposed or not exposed to Happy10 School-based PE program 30 min sessions, 4x/wk 9-11 y/o school girls from 4 schools (2 Intervention; 2 Reference) Almas (2013)63 2008 QE1 Pakistan people (adults/chi ldren/yout h) observed during 5589 observatio n visits to ACP and non-ACP parks N = 2267 Observed SOPARC among people visiting both ACP and non-ACP Parks ACP parks more likely to engage in MVPA (64% vs. 49%) Meeting PA guideline s based on leisuretime MVPA N = 4700 Selfreport PA – 7 day recall; BMI z scores Meeting guidelines was associated with having ever heard about ACP [OR 1·8 (95% CI: 1·4, 2·2)]; having seen a ACP class [OR = 1·6 (95% CI: 1·1, 2·3)]; being a current ACP participant [OR = 14·3 (95% CI: 12·3,16·4)]; and being a past ACP participant [OR =4·0 (95% CI: 1·4, 11·3)] Mean ∆ in BMI z scores between I schools vs. R schools = -0·15 kg/m2 I = 131 R = 146 Adherenc e to PE classes; Reported PA More women (45% vs. 42%) and older adults (14·7% vs. 5·7%) in ACP vs. nonACP sites Post 1** and 2*** year = I maintained BMI z vs. R schools I adherence = 80%; R adherence = 78·5% 4 years 2 years 20 weeks No net difference in reported PA Jemmont (2014)53 2007– 2010 RT4 South Africa Small group activities, games, brainstorming, videos, discussions Men reporting coitus in the previous 3 months and living in one of the selected neighborhoods randomized to condition (PA vs. 33 I = 572 C = 609 Adheren ce to PA guidelin es by selfreport % Meeting PA guidelines Total PA OR – I vs. C = 1·28 (1·05, 1·57); PA vig – 1·30 (1·06, 1·57); PA mod – OR 1·25(1·02, 1·52) 1 year attention-control) Policy and Environmental/Community-wide Policies and Planning Torres 2009 CS3 Colombi Community Adult residents of 65 (2013) a planning and selected community policies – Ciclovia (public streets) and Cicloruta (bike paths) Ciclovia N =1000 Cicloruta N=1000 Meeting PA guidelin es Meeting PA guidelines among regular participants vs. infrequent participants of Ciclovia – OR = 1·7 (1·1, 2·4) Meeting PA guidelines among regular users vs. infrequent users of Cicloruta – OR = 10·2 (6·1, 16·8) 1 Quasi-experimental – intervention and referent communities/sites Cohort – pre-intervention and post-intervention measures 3 Cross Sectional – pre – post intervention measures 4 Randomized prospective study – intervention vs. control group 5 Other *= p<0·0001 **= p<0·01 ***= p< 0·05 2 34 N/A Appendix 12: Exemplary Interventions from Low- and Middle-Income Countries Author/Year of Publication: Rabiei, et al., 2010 51 Intervention strategy: Community-wide campaign Country: Iran Study design: Longitudinal – quasi-experimental Study Period: 6 years – 2000–2002 A Non-communicable disease (NCD) intervention project was carried out in a major Iranian urban center with a population of ~1·8M. A comparison urban center of ~ 670,000 served as the referent community. NCD risk factor assessments (surveys) were carried out at baseline in year 2000, with a survey sample size of 6126 in the Intervention community and 6293 in the referent community. Subsequent surveys following 1 year of intervention were 2937 in the intervention community and 2887 in the referent community, with the final year of follow-up yielding sample sizes of 2364 and 2381 respectively for the intervention and referent sites. The intervention strategies included educational interventions, environmental, and legislative efforts to promote physical activity as the primary NCD prevention strategy. This included provider-based assessment and counseling for physical activity across the lifecycle. These efforts were complemented by neighborhood-based physical activity community groups and population-specific media targeting with physical activity messages. Environmental interventions including improved infrastructure for active transport by bicycle and pedestrian activities, increased park space, and increased physical activity programming in these public spaces was also carried out. The referent community did not have any of the aforementioned intervention strategies, were isolated from media messaging which targeted the intervention community, and were only provided with routine medical care and public health services. An assessment of the physical activity outcomes were carried out using the Baecke Questionnaire for the assessment of leisure –time physical activity (LTPA). This measure was initially assessed among all respondents to the community surveys at baseline and then subsequently at the end of year 1 and year 2. Results indicated a 13·4% and 6·5% increase in the levels of measured LTPA among women in the intervention and referent communities after year 1, respectively. These differences provided a significant (p<0·0001) net intervention effect favoring the intervention community. During this same period, LTPA increased among intervention community men by 7.3%, while LTPA levels fell by a 35 -10·87% among the referent community men (p<0·05, net intervention effect). Examining changes in active transport, the intervention women registered a -3·3% drop in active transport compared to a -30·93% drop among referent community women (p<0·0001), while intervention men dropped -12·4% and referent men -46·7% in active transport (p<0·0001). An explanation for these findings can partially be explained by the significant increase in motorized transport infrastructure placed in both communities during the course of the study period, despite this, the intervention community demonstrated a lesser impact on active transport compared with the referent community. Author: Parra, et al., 2010 59 Country: Brazil Intervention strategy: Social and Behavioral Approaches Study Design: Cross sectional observations of physical activity in intervention parks and non-intervention parks Study Period: 2002–2007 Residents of Recife, Brazil were exposed to an Intervention strategy that consisted of physical activity promotion through physical activity classes at no cost in public parks. The physical activity classes were delivered 3x per week by qualified physical activity instructors in local “public spaces.” The intervention period started in 2002 with cross sectional observations being completed by the close of 2007. Children, youth, adults, and older adults were observed either in parks that offered Academia da Cidade Programs (ACP), the free leader led group physical activity programs in parks or Non-ACP parks. Physical activity of adults, children, youth, and older adults was measured by using the System for Observing Play and Recreation in Communities (SOPARC) in 128 targeted areas in 10 park sites (5 ACP sites, 5 non-ACP sites) to obtain data on the number of users and their physical activity levels and estimated age. Each area was assessed 4 times a day for 11 days over a 4-week period. Observed physical activity included moderate-to-vigorous and vigorous physical activity. A total of 32,974 people were observed during 5589 observation visits to the targeted park areas. The investigators found that people using ACP parks were at greater odds of being observed engaging in moderate-to-vigorous (64% vs 49%) and vigorous (25% vs 10%) physical activity compared with observations of people frequenting non-ACP parks. More participants in ACP sites 36 compared with participants at non-ACP sites were females (45% vs 42% of park users) and older adults (14·7% vs 5·7%) among park users). Author: Torres et al., 2013 65 Country: Bogota, Colombia Intervention: Community planning and policies Study design: Cross-sectional population-based surveys Intervention duration: Ciclovia and Cicloruta activities, 2004–2010 Physical activity interventions were implemented starting in 2004 with a community event, “Ciclovia,” a community – wide physical activity opportunity provided every week (Sunday afternoons) through streets which are closed to motorized vehicular traffic. Implemented in Bogota, the largest city in Colombia, SA. A second, concurrent community-wide intervention, ‘Cicloruta’ consists of construction of bicycle infrastructure comprised of dedicated bikeways which is shielded from motor traffic accompanied by a community-wide informational campaign promoting active transport and recreation. Two population-based surveys among community respondents were conducted to assess both exposure to these intervention strategies and the impact of such exposure on physical activity behaviors. The study population consisted of urban residents of Bogota, Colombia who were adults 18 and older who either had used the Cicloruta or had been a participant in Civlovia. The sample size consisted of 1000 respondents for each of the surveys. The survey instrument used to assess physical activity was the International Physical Activity Questionnaire (IPAQ) long version. The outcome of interest was the odds of participants meeting the national and World Health Organization physical activity guidelines. Among respondents who were regular participants in the Ciclovia compared to participants who were infrequent participants, the regular participants were over 1·7 (95% CI, 1·1, 2·4) the odds of meeting physical activity guidelines. Similarly, participants who were regular users of the Cicloruta compared with infrequent users were 10·2 (95% CI, 6·1, 16·8) times the odds of meeting physical activity guidelines than their infrequent counterparts. 37