Document 6431307

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Document 6431307

DIALOG File 5 : BIOSIS PREVIEWS 69-87/AP
0016032931 BIOSIS Number : 8101-1847
PRENATAL NICOTINE AFFECTS FETAL TESTOSTERONE AND SEXUAL DIMORPHISM OF
SACCHARIN PREFERENCE
LICHTENSTEIGER W ; SCHLUMPF M
PHARMAKOL . INST ., UNIV . ZURICH, GLORIASSTR . :32, CH-8006 ZURICH, SWITZ .
PHARMACOL BIOCHEM BEHAV 23 (3) . 1985 . 4719-444 . CODEN : PBBHA
Language : ENGLISH
In order to study effects of nicotine on fetal gonadal axis and sexually
time-pregnant Sprague Dawley rats were implanted on
dimorphic behavior,
gestational day (GD) 12 with an osmotic minipump containi-ng either nicotine
tartrate, ~rtaric acid_ or saline . Others were sham-operated on GD 12 or
left untreated . Male fetuses of all control groups displayed the
characteristic rise in plasma testosterone at GD 18 (as compared to GD 17
and 19) ; this was abolished by nicotine . Adult offspring of-untreated or
tartaric acid-treated dams exhibited a marked sexual dimorphism in their
preference for saccharin-containing drinking water at 0 .06-0 .25% . No such
sex difference was seen in offspring of nicotine-treated rats . In controls,
the sexes tiiffered with respect to the proportion of rats with high
saccharin preference . In the group of males prenatally exposed to nicotine,
the proportion of animals with high preference increased to the female
level . These data indicate that prenatal exposure to nicotine can interfere
with the development of the male gonadal axis and with the organization of
sexually dimorphic behavior .
-
0014190920 B I OS I S Number : 77023904
THE RECOVERY PERIOD OF THE TASTE RESPONSES OF RAT CHORDA TYMPANI AFTER
APPLICATION OF TOOTHPASTE
TOYONO Y ; NABESH I MA J
BIOL . SCI . LAB ., LION CORPORATION, 2C>2 TAJIMA, ODAWARA, k ;ANAGAWA
PREFECTURE, 256, JAPAN .
J TOXICOL SCI 8 (2) . 1983 . 133-140 . CODEN : JTSCD Language : ENGLISH
The recovery period of the taste responses of rat chorda tympani after
application of toothpaste was examined . The response observations of 4
kinds of essential taste stimuli, 0 .1 M NaC1, 0 .005 M quinine
hydrochloride, 1 .0 M sucrose and 0 .05 M tartaric ac~, were repeated every
2 or 5 min . After 5 observations of summated responses of the chorda
tympani with each taste stimulus, a toothpaste solution diluted 3 :1 was
applied to rat tongues for 3 min and then they were-washed with distilled
water for 1 .5 min . Thereafter, observations of the responses to each taste
stimulus were repeated at 2 or 5 min intervals for 30 or 60 min . The
responses caused by- 4 kinds of essential taste stimuli became smaller
immediately after application of toothpaste, and then gradually returned to
normal . The same experimental procedure was also applied using an
application of distilled water instead of an application of toothpaste to
rat tongues . A t-test was performed between the response ratios after
application of toothpaste and those after application of distilled water .
Significant differences disappeared at 18 min after application of the 0 .1
M NaC1 stimulus, at 23 min of the 0 .005 M quinine hydrochloride stimulus,
at 15 min of the 1 .0 M sucrose stimulus and at 15 min of the 0 .05 M
tartaric acid stimulus . All taste responses recovered within at least 50
mi n .
http://legacy.library.ucsf.edu/tid/gzo30e00/pdf
87494935
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75045923
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0013195923 BIOSIS Number :
SHORT-TERM TOXICITY STUDY OF META TARTARIC-ACID IN RATS ~
INGRAM A J ; BUTTERWORTH K R ; GAUNT I F ; GANGOLLI S D
BRITISH INDUSTRIAL BIOL . RESEARCH ASSOCIATION, WOODMANSTERNE ROAD,
CARSHALTON, SURREY SM5 4DS, ENGLAND .
FOOD CHEM TOXICOL 20 (3) . 1982 . 253-258 . CODEN : FCTOD ,
Language : ENGLISH Subfile : BA (Biological Abstracts)
6roups of rats were given metatartaric acid -in the drinking water at 0
(control), 0 .1, 0 .5 or ? .U% for 18 wk . No-effects associated with treatment
were seen in the results of the hematological examinations and serum
analyses . The treated animals consumed less water and food than the
controls, probably because of the unpalatability of the test material .
Administration of the 3%_solution was associated in males with a reduced
growth rate, some impairment of urine concentrating ability during
prolonged water_ deprivat-ion (also seen in- males on h .5Z)- and
histopathological changes in the stomach indicative of an inflammatory
response in the submucosal layer . Both sexes of the 3% group showed an
increase in relative kidney weight without accompanying histopathological
change . The no-untoward-effect level in this study was 0 .1% metatartaric
acid in the drinking-water, equivalent to a mean daily intake of 80 mg/kg
body wt in males-and 130 mg/kg in females .
001 1271235 BI OS I S Number : 72056219
STRUCTURAL REQUIREMENTS FOR CHELATE ANTIDOTAL EFFICACY IN ACUTE ANTIMONY
III INTOXICATION
BASINGER M A ; JONES M M
DEP . OF -CHEM . , CENT . ENVIF:ONMENTAL -TOXICOL . , VANDERBILT UNIV ., NASHVILLE,
TENNESSEE 37235 ._
RES .COMMUN CHEM_FATHOL PHARMACOL 32 (2) . 1981 . 355-364 . CODEN : RCOCB
Language : ENGLISH
Subfile : BA (Biological Abstracts)
LD50 for i .p . potassium antimonyl tartrate [an antischistosomiasis drug]
was 54 .6 mg/kg in mice, with a 95% confidence range of 48 .4-61 .7 mg/kg-. An
examination of the antidotal efficacy of a number of different structural
types of chelating agents, showed that few types were able to act as
antidotes when potassium antimonyl tartrate was administered i .p . to mice
at a level of 120 mg/kg . The most effective antidotes were the water
soluble vicinal di-thiols : 2,3-dimercaptosuccinic acid CBAL] and sodium
2,3-dimercaptopropane-l-sulfonate ; the first was significantly better . Less
effective was D-penicillamine . At- this level of administration of Sb (III),
HAL was not an effective antidote . Among other chelating agents which were
also not effective at this level of Sb (III) were tartaric acid, EDTA, Cys,
sodium diethyldithiocarbamate-and potassium dithiooxalate .
3
I
-0011248743 BIOSI-S Number : 72033727
EFFECT OF ALPHA DI FLUOROMETHYL ORNITHINE- AND TARTARIC-ACID ON SPERM
COUNT SEMINAL GAMMA GLUTAMYL TRANSFERASE FOLLICLE STIMULATING HORMONE
LUTEINIZING HORMONE TESTOSTERONE AND STEROID EXCRETION IN PATIENTS WITH
CHRONIC PROSTATITIS DUNZENDORFER U ;
FELLER
H
_
UNIVERSITAETSKLINIKEN FRANKFURT/MAIN, ABTEILUNG FUER UROLOGIE,
THEODOR-STERN-KA I 7, D-6000 FRANKFURT AM, MA I N 70 .
ANDROLOGIA 13 (21 . 1981 . 100-107 . -CODEN : ANDRD
Language :
ENGLISH
Subf i 1 e : BA (Bi ol ogi cal Abstracts) The inactivation of ornithine decarboxylase, a polyamine biosynthetic
enzyme, by
.alpha .-difluoromethylornithine ( .alpha .-DFMO) was studied in
patients with chronic non-suppurative prostatitis . -Partial clinicalresponse and remission-6f gross hematospermia were observed after 18 g/day
testosterone- in semen and also of sperm motility and vitality appeared
distinctly changed in
.alpha .-DFMO treated patients, indicating a
significant effect on the activity of the prostate . A 16% decrease of
hematocrit and Hb in 2 out of 10 patients was rever5ible 2 mo . after
stopping the therapy . The placebo, which was identified mainly as tartaric
acid after termination of the study, showed a similar clinical response and
change of seminal paramet-ers . The modulation of sperm count, seminal
prostatic acid phosphatase by tartaric acid in vitro .
00102535031 B I OSI S Numb er : 70045999 EFFECTS OF TRIVALENT AND HEXAVALENT CHROMIUM ON LIPID PER OXIDATION IN
RAT LIVER MICROSOMES
YONAHA M ; OHBAYASHI Y ; NOTO N ; ITOH E ; UCHIYAMA M- - HOKKAIDO INST . PHARM . SCI ., 7-1 KATSURAOF':A, OTARU, HOk;F`:AIDO, JPN .
CHEM PHARM BULL ( TOKYO ) 28 (3) . 1980 . 89 .'_•-899 . CODEN : CF'BTA Language : ENGLISH
The effects of-heavy metals, especially Cr, on lipid peroxidation-in rat
liver microsomes were studied . Lipid peroxidation -was determined as
thiobarbituric acid=reacting materials . At lower concentrations in the
range of 1-100
.mu .M, both hexavalent and trivalent Cr inhibited lipid
peroxidation induced by ascorbate or NADPH in microsomes . In the presence
of ascorbate, the inhibitions decreased- on treatment wi-th sulfhydryl
reagents and were partly overcome by the addition of tartaric aciA6 Cr,
presumably in the trivalent -form, may bind with sulfhydryl groups of
protein, causing the inhibition of lipid peroxidation . In the presence of
NADPH, hexavalent Cr showed very potent inhibition . Hexavalent and
trivalent Cr did not inhibit the electron-transport system in microsomes .
The hexavalent form may act as a radical scavenger, since it strongly
inhibited - CC14-stimulated lipid peroxidation, could reduce
2,2'-diphenyl- .beta .-picrylhydrazyl to some extent in the presence of a
reducing agent such as ethanol, and inhibited NADPH-induced peroxidation
markedly in the presence of sulfhydryl compounds . Above 1 mM, hexavalent Cr
caused lipid peroxide formation in microsomes, apparently not associated
with Fe, while trivalent Cr showed an inhibitory effect .
4
0
_0o092L3120 B I OS I S Number : 68025624
HEMOLYTIC EFFECT OF SOME POLAR LIPIDS USED AS FOOD ADDITIVES
LARSSO N K' ; JOHANSSON L-A
DEP . FOOD TECHNOL ., UNIV . LUND, BOX _740, S-220 07 LUND, SWED .
LEBENSM-WISS TECHNOL 11 (4) . 1978 . 206-208 . CODEN : LBWTA
Language : ENGLISH
for - the -following
food -additives :
Hemolytic
effects are reported
monoglycerides , sodium stearoyl-lactyl lactate (NaSLL), a diacetyl tartaric
acid ester of monoglycerides (DATE) and a polyglycerol ester . The results
obtained from these polar lipids compared to a lecithin, a lysolecithin and
a fatty acid show that NaSLL (frequently used in industrial baking)-is the
only lipid exhibiting a- strong- solubilizing effect on the _Chuman]
erythrocyte sur-face membrane . NaSLL gave a slightly stronger hemolysis than
lysolecithin of the same concentration . Lysolecithin reportedly damages the
gastri c mucosal barr-i er and may be a f actor i n the et i ol ogy -of gastri c
ulcer . Whether or not NaSLL similarly affects the gastric mucosa should be
evaluated from studies in vivo .
0009215004 BIOSIS Number : 68017508
OPTICALLY PURE DEXTRO NICOTINE FROM R-S NICOTINE AND BIOLOGICAL
COMPARISON WITH LEVO-NICOTINE
7
ACETO M D ; MARTIN B R ; UWAYDAH I M ; MAY E L ; HARRIS L S ; IZAZOLA-CONDE C ;
DEWEY W L ; BRADSHAW T J ; VINCEI<; W C
DEP . PHARMACOL ., MED . COLL . VA ., RICHMOND, VA . 23298, USA .
J MED CHEM 22 (2) . 1979 . 174-177 . CODEN :-JMCMA
Language : ENGLISH
Optically pure -(+)-nicotine was= obtained from ( .+- .)-nicotine using a
combination of d-tartaric acid and di-p-tol-Lioyl-l-tartaric acid . As the
di-d-tartaric salt, (+)-nicotine -is less potent than (-)-nicotine
di-l-tartrate in producing lethality in mice, on blood pressure in
anesthetized rats, and in the isolated guinea-pig ileum, indicatingsubstantial stereospecificity for nictone receptors . Potency ratios are
4 . 14, 0 .06 and 0 .019, respecti vel y .
-
5
00092037731 E+ I OS I S Number : 68006235
TASTE PREFERENCE AND TASTE NERVE RESPONSES OF RATS UNDER COPPER TOXICOSIS
YAMAMOTO T ; F:OSLIGI T ; k::AWAMLIF:A Y
DEP . ORAL PHYS I OL. . , DENT . SCH ., OSAKA UN I V ., 4-3-48 NAF':ANOSH I MA , KI TAKU ,
OSAKA 5301 JF'N .
PHARMACOL BIOCHEM BEHAV9 (6) . 1978 (RECD . 1979) . 799-808 . CODEN :
PBBHA
Language : ENGLISHSubfile : BA (Biological Abstracts) Effects of administration of CuC12 on the taste preference for the 4
basic taste solutions were studied by 2 bottle preference tests in rats .
The i .p . injection of 450 mu .g CuC12/100 _g-B .W . [body weight] per day for
2 wk induced no_-significant changes in the taste preference for both NaCl
and sucrose solutions . The taste preference for- tartaric acid and
quinine-HC1 solutions was influenced by CuC12 injection ; 10 of 27 rats took
tartaric acid or quinine- solutions as much as water, and 4 of 27 rats
showed a marked increase in fluid intake for tartaric acid or quinine
solutions over water . Discontinuation of Cu administration restored the
altered preference responses to the preference level seen in the control
period . Patterns of the summated taste nerve response to various
concentrations of the 4 basic taste stimuli in the Cu-injected rats were ~
similar to those in the control rats . The possible mechanisms by which Cu
injection alters preference behavior are discussed .
65055757
&-10002168757 B I OS I S Number :
RENAL AND BONE UPTAKE OF TARTARIC-ACID IN RATS COMPARISON OF L-DEXTRO AND
DL FORMS DOWN W H ; SACHAF:I N R M ; CHASSEAUD L F ; F:I RKF'ATR I CK : D ; FRANF' :L I N E R
DEP . METAB . PHARMACak :IPJET ., HUNTINGDON RES . CENT ., HUNTINGDON, ENGL ., UK .
TOXICOLOGY 8 (3) . 1977 (RECD 1978) 3'3-'46 . - CODEN : T-XCYA Language :
ENGLISH
Subfile : BA (Biologi-cal Abstracts)
Plasma concentrations of radioactivity declined biphasically with
half-lives of about- 15 and 58 h, respectively, in rats dosed with
monosodium DL-C14C7tartrate for 7 days at a dose level of 2 .73 g/kg per
day . Uptake and retention of radioactivity occurred in blood cells, kidneys
and bones where it was detected for at least 12 days after dosing . Renal
retention (11202
.+- . 4469 ppm at 6 h, n = 7) was probably due to
precipitation of the poorly soluble calcium DL-tartrate in the tubules
leading to increased E::idney weight, nephrotoxicity and even death . The more
soluble, naturally-occurring L(+)-[14C]tartrate was not retained in the
kidneys (1287
.+- . 118 ppm at 6 h, n = 8) when administered to rats under
the -same conditions, and the initial decline of plasma concentrations of
radioactivity was more rapid (tO .5 [1/2 time] 3 h) . For this reason
monosodium L(+)-tartrate was non-toxic at 2 .73 g/kg per day, whereas
monosodium DL-tartrate was toxic at this dosage . CTartaric acid is used in
medicine and in food .]
6
0008149993 BI OS I S Numb er : 65036993
MONO SODIUM L-DEXTRO TARTRATE TOXICITY IN 2 YEAR DIETARY FEEDING TO RATS
HUNTER B ; BATHAM F' ; HEYWOOD R ; -STFtEET -A E ; PRENTICE D E
DEP . GEN . TOXICOL ., HUNTINGDON RES . CENT ., HUNTINGDON, ENGL ., UK' .
TOXICOLOGY 8(2) . 1977 26T-~'_74 . CODEN : TXCYA
Language : ENGLISH
Monosodium L(+) tartrate was fed to rats in their diet for a total period
of 2 yr at levels of 25,600, 42,240, 60,160 and 76,800 ppm . The survival of
rats receiving 42,240, 60,160 and 76,800 ppm was superior to that of the
controls and probably correlated with the lower food intake of these groups
and the restiltant reduced body weight gain . There were no adverse clinical
signs and the investigation of the animals' eyes, blood and urine did not
reveal any reaction to treatment, nor were changes to related to treatment
seen in the macroscopic pathology or organ weights of rats killed after 104
wk . Histological examination of the tissues did not show evidence of
toxicity or tumor induction that coul-d be attributed to treatment withmonosodium L(+) tartrate . CTartaric acid and its salts are used in the food
industry as synergists with antioxidants, as acidulants and as leavening
agents .)
#
0016122705 BIOSIS Number : 30063953
INFLUENCE OF VEHICLE ON THE CARDIOVASCULAR EFFECTS OF BROMOCRIPTINE
MORALES-OLIVAS-F J ; RUBIO E ; PALOP V ; GARCIA-DIEZ J M
DEP . FARMACOL .i FAC . MED ., UNIV . VALENCIA, AVDA, BLASCO IBANEZ, 15, 46010
VALENCIA, SF'AIN ._
IRCS (INT RES COMMUN SYST) MED SCI13 (12) . 1985 (RECu . 1986) .
1207-12U8 . CODEN : IMSCE
ENGLISH
Language :
Subf i 1 e : BARRM (8i ol ogi cal Abstracts/RRM)
Descriptors/Keywords : RAT ANTIHYPERTENSIVE-DRUG PHARMACODYNAMICS TOOL
DOPAMINE AGONIST ALCOHOL GLYCEROL TARTARIC-ACID
Concept Codes :
*14508 Cardiovascular System-Blood Vessel Pathology
*20504 Nervous System-Physiology and Biochemistry
*22002 Pharmacology-General
*22010 Pharmacology-Cardiovascular System
*22024 Pharmacology-Neuropharmacology
*22100 Routes of Immunization, Infection and Therapy
*22504 Tox-icology-Pharmacological Toxicology (197^c- )
1D460 Biochemical Studies-General
10064 Biochemical Studies-Proteins, Peptides and Amino Acids
51522 Plant Physiology, Biochemistry and Biophysics-Chemical
Constituents
54000 Pharmacognosy and Pharmaceutical Botany
Piosystematic Codes :
86375 Muridae
Super Taxa :
Animals ; Vertebrates ; Nonhuman Vertebrates ; Mammals ; Nonhuman
Rodents
7
0015174444- BI OS I S Numb er : 79091237
-OCCUPATIONAL EXPOSURE TO TARTARIC-ACID
MOSCATO G ; F'ELISSEF;O-G ; MARCHETTI R ; NALDI L ; ZECCA E ; PRESTINONI A ;
PIACENTINO G ; MUSSI U IST . DI MED . DEL LAVORO, VIA SEVERINO BOEZ_IO 24-2-7100 PAVIA .
G ITAL MED LAV 5(5) . 1983 (RECD . 1985) . 1 .93-198 . -CODEN : GIMLD
Language : IT_ ALIAIy.
Subfile : BA (Bioloqical Abstracts)
Descriptors/Keywords : HUMAN OROPHARYNGEAL CUTANEOUS LESIONS ANAMNESTIC
QUESTIONNAIRE SPIROMETRY BRONCHODILATION TEST
Concept Codes : *14006 Di gest i ve System-F'athol ogy- *16001 Respiratory System-General- ;- Methods
*185t>6 Integumentary System-Pathology *19U06 Dental and Oral Biology-Pathology - *22506 Toxicology-Environmental and Industrial Toxicology
*37013 Public Health : Environmental He-alth-Occupational Health
*37015 Publ i c Heal_th : Envi ronmental Heal th-Ai r, Water and Soi 1 F'ol 1 ut i on
04500 Mathematical Esiology and Statistical Methods
10060 Bi ochemi cal Studi es-GeneraT
14001 Digestive System-General ; Methods
18501 Integumentary System-General ; Methods
19001 Dental and Oral Biology-General ; Methods Biosystematic Codes :
86215 Hominidae
Super Taxa :
Animals ; Vertebrates ; Mammals ; Primates ; Human
0013014876 BI08IS Number : 24014876
MUTAGENICITY OF-THE-PYBn!y~ PRODUCTS OF AMMONIUM SALTS
YOSHIDA D ; OKAMOT0 H CENT . RES . INST ., JAPAN TOBACCO,-SALT PUBLIC CORP ., 6-2 UMEGHOF ;A,
MIDORI-KU, YOKOHAMA 227, JAF'AN .
AGRIC BIOL CHEM 46 (4) . 1982 . 1067-1068 . CODEN : ABCHA
Language : ENGLISHSubfile : BARRM (Biological Abstracts/RRM)
Descriptors/Keywords : SALMONELLA-TYF'HIMUF:IUM SULFATE ACETATE OXALATE
TARTARIC-ACID MALIC-ACID QITRIC-ACID MALATE CITRATE ALBUMIN OXALIC-ACID
TARTARIC-ACID - Concept Codes :
*03502 Genetics and Cytogenetics-General
*22501 Toxicology-General ; Methods and Experimental *31500 Genetics of Bacteria and Viruses 01054 Microscopy Techniques-Cytology and Cytochemistry
10060 Biochemical Studies-General
10064 Biochemical Studies-Proteins, Peptides and Amino Acids
Biosystematic Codes :
04810 Enterobacteriace-ae (1979- ) Super Taxa :
Microorganisms ; Bacteria
~
8
4
00061523.72 BI OS I S Numb er : 61 052372
INFLUENCE OF DIFFERENT CARBOXYLIC ACIDS ON ENAMEL DISSOLUTION IN THE
PRESENCE AND ABSENCE OF SUCROSE MCDONALD J L JR ; STOOKEY G K: 54 (1) . 1975 187 . CODEN : JDREA J DENT RES
Descript ors/i: :e ywords : HUMAN FOOD BOVINE EACTERIA FRUIT JUICE FRUIT CANDY
GELAT I N SOFT DF I NF, POWDERED BEVERAGE AD I P I C-AC I D GLUTARI O-AC I D MAL I C-AC I D
CITRIC-ACID TARTARIC-ACID FUMARIC-ACID PH DECALCIFICATION
Concept Codes :
*13010 Metabolism-Minerals
*13502 Food Technology-General ; Methods
*13504 Food Technology-Fruits, Nuts and-Vegetables
*13530 Food Technology-Evaluations of Physical and Chemical F'roperties
(1970- )
*135u2 Food Technology-Preparation, Processing and Storage (197Cr° )
*13534 Food Technology-Synthetic, Supplemental and Enrichment Foods
(1970- )*19U06 Dental and Oral Biology-Pathology
* 2 2 5 0 2 Toxicology-Foods, Food Residues, Additives and F'reservatives
10060 Biochemical Studies-General 10068 Biochemical Studies-Carbohydrates
10069 Biochemical Studies-Minerals31Cr00 F'hyGi ol ogy and Bi ochemi stry of Hacteri a
36002 Medical and Clinical Microbiology-Bacteriology
53012 Horticulture-General ; Miscellaneous and Mixed Crops
Biosystematic Codes :06000 Bacter i a-Llnspec i f i ed (1969-7F3)
25200 Angiospermae
85715 Bovl da.e
86215 Homi ni dae
Super Taxa :
Microorganisms ; Bacteria ; Plants ; Vascular Plants ; Animals ; Vertebrates ;
Nonhuman Vertebrates ; Mammals ; Nonhuman Mammals ; Primates ; Human
9

Document 6431307

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