CholeSterol Formula With Sytrinol Supports normal cholesterol levels

research
information
Cholesterol Formula
with Sytrinol
TM
Supports normal cholesterol levels
Are you looking for a natural way to reduce moderately high
levels of cholesterol without resorting to the ever-popular
‘statins’? Cholesterol Formula, combining plant sterols with
Sytrinol has proven to be effective! Of course, diet and
exercise are the building blocks of cardiovascular health, but
even a heart-healthy diet may not bring down those numbers enough. The reason is simple: only 20% of our cholesterol actually comes from our diet, the other 80% is made in
the liver. That’s why statin drugs have proved effective. They
target one of the liver’s cholesterol producing mechanisms.
Unfortunately, that same mechanism also produces coenzyme Q10 (CoQ10). The side-effect is that prolonged use of
statin drugs cause severe deficiency of CoQ10, required for
healthy muscle tissue (the heart is a muscle). It can also result
in debilitating muscle deterioration.
Combining plant sterols (SterolSource™) with Sytrinol
provides a comprehensive formula that addresses all facets of
dyslipidemia including high cholesterol, high LDL (low
density lipoproteins, the “bad” cholesterol) and high
triglycerides. This formula also contains a significant
anti-inflammatory component as inflammation has been
shown to be a risk factor for heart attack. This amazing
natural heart health formula is ideal for anyone wishing to
maintain a healthy lipid profile.
Measured endpoints
Total Cholesterol
LDL Cholesterol Total Triglycerides
HDL Cholesterol
LDL/HDL Ratio
Treatment
group
Sytrinol
Sytrinol
Sytrinol
Sytrinol
Sytrinol
% Change (4 weeks)
Study 1
Study 11 Study III
-25%b
-19%b
-24%b
nc
-19%b
-20%b
-22%b
-28%b
3%
-24%b
-25%b
-23%b
-29%b
4%
-26%b
Means + SEM Statistical analysis by ANOLVA plus post test by
Dunnett’s method
nc - no change from baseline
b
- significantly different within same group. P < 0.05
Why Plant Sterols?
In 2000 the FDA allowed a label claim by the manufacturers
of certain margarines and spreads that plant sterols reduce
the risk of coronary heart disease. The FDA extended this
claim for supplements containing sterols. These claims are
based on numerous studies going back 50 years that show
that plant sterols and stanols can effectively lower total and
LDL cholesterol levels.
Blood cholesterol levels are derived from two sources:
endogenous synthesis (made by the body) and from animal
products in our diet. Some of the endogenous cholesterol is
released with bile into the intestine where it can be reabsorbed. “Phytosterol esters/sterols work by reducing absorption of both cholesterol sources, dietary cholesterol and
The Dark Side of Statins
Government guidelines have suggested that target LDL levels be reduced from the current 100 mg/dl to 70 mg/dl in
patients considered to be high risk for heart attack or death
from cardiovascular disease. Persons with only a moderate risk for heart attack are being encouraged to lower
their cholesterol levels by 30 to 40%. Not surprisingly,
the guidelines could dramatically increase the number of
patients on statin drugs to as many as 50 million.
In an embarrassing oversight, the same government panel
drafting the guidelines failed to mention in its report
that most of its panelists are linked to pharmaceutical
companies that manufacture statin drugs. Six of the nine
panelists had either received grants from or were paid consulting or speakers’ fees by the companies that make some
of the most popular statins, including Pfizer’s Lipitor®,
Bristol-Myers Squibb’s Pravachol®, Merck’s Mevacor®, and
AstraZeneca’s Crestor®.” Life Extension Magazine November
2004.
While statins have a clear benefit, they also can have
adverse effects:
• Liver problems and elevated liver function tests.
• Interference with coenzyme Q10 production resulting in damaging deficiency.
• Rhabdomyolysis (muscle pain and weakness), the
breaking down of muscle tissue which can prove
fatal. Between October 1997 and December 2000
statin drugs were linked to 72 fatal and 772 nonfatal cases.
• Polyneuropathy (nerve damage) with chances of
nerve damage 26 times higher than the normal population.
• Brain and central nervous system functions (after
prolonged use some patients suffered measurable
decline in cognition).
endogenous cholesterol. Phytosterol esters/sterols have
chemical structures very similar to cholesterol and interfere
with cholesterol absorption.” (Veris)
This information is provided for educational purposes only, and is not intended for self-diagnosis or self-treatment of conditions that should be assessed and treated by your
health care practitioner. While the information contained in this document has been carefully reviewed and reflects current clinical and scientific knowledge, it is subject to change.
© All rights reserved – Natural Factors Nutritional Products Ltd. • Enquiries: custservice@naturalfactors.com • 30555 •August 4, 2009 • Pg 1 of 2
Where Great Health Begins
research information
Cholesterol Formula with Sytrinol
TM
Plant sterols or phytosterols have been
proven to lower cholesterol levels from
7 to 15%. In the ester form and in sufficient quantities, plant sterols and
stanols can inhibit absorption of
cholesterol in the small intestine by up
to 50%, and lower LDL blood cholesterol by up to 14%. The most common
plant sterols are sitosterol, campesterol
and stigmasterol.
What is Sytrinol?
It’s well-known that drinking orange
juice can reduce cholesterol. However,
specific citrus flavonoids, particularly
nobiletin (first isolated from orange
peels) and the tangerine flavonoid
tangeretin have been shown to reduce
cholesterol and triglycerides, lower
inflammation and reduce apopiloprotein B3. Sytrinol is a patented proprietary formula derived from these
natural citrus and palm fruit extracts. It
inhibits the enzymes responsible for
increasing the liver’s cholesterol and
triglyceride production. Three of its
complementary mechanisms of action
in the body that deliver the cardiac
health benefits are:
• Polymethoxylated flavones (PMFs)
decrease apolipoprotein B, a structural
protein needed for endogenous synthesis of LDL cholesterol.
“Apolipoprotein B particles enable
cholesterol to penetrate and lodge in
vascular walls, an important step in
initiating the formation of atherosclerotic plaque.” (English)
• PMFs (tangeretin and nobiletin)
decrease diacylglycerol acetyl transferase, a liver enzyme needed for
endogenous synthesis of triglycerides.
• Palm tocotrienols inhibit HMG CoA
reductase, a liver enzyme responsible
for endogenous synthesis of cholesterol.
Sytrinol also provides powerful antioxidant with anti-inflammatory properties
that support a healthy cardiac system.
Backed by Research
Clinical results have demonstrated that
Sytrinol can improve total cholesterol
levels up to 30%, LDL cholesterol levels
up to 27% and triglyceride levels up to
34% within four to twelve weeks.
Additionally, clinical trials have
demonstrated that Sytrinol can have a
positive impact on apolipoprotein (also
known as apoprotein) B and apolipoprotein A1 levels as well as playing a
significant role as an anti-inflammatory.
Sytrinol can do all this without the
negative side-effects associated with
pharmaceutical drugs.
Sytrinol and Sterols –
Positive Synergy
The Cholesterol Formula provides
200 mg of SterolSource plant sterols
(standardized to >95% total sterols)
combined with 75 mg of Sytrinol
phytosterol, a patented formula derived
from natural citrus and palm fruit
extracts (standardized to >30%
polymethoxylated flavones and
tocotrienols). Together, SterolSource and
Sytrinol have a greater biological impact
than each component individually. In
the digestive tract this formula inhibits
the absorption of cholesterol from foods
consumed and reduces cholesterol
reabsorption (liver and gall bladder bile
is 90% cholesterol, much of which is
reabsorbed back into the bloodstream
from the digestive tract). In the liver
this combination reduces the amount of
cholesterol made by inhibiting the
enzymes that produce cholesterol.
What you can expect from
the Cholesterol Formula
It may lower total cholesterol and “bad”
LDL cholesterol and may help maintain
(and even slightly increase) levels of the
“good” HDL. Components in the
Cholesterol Formula have been shown
to significantly lower triglyceride levels
and may reduce inflammation of the
heart and blood vessels with none of
the side-effects associated with statins.
Dosage
Two capsules 2 times daily or as directed
by a health care practitioner. Best when
used as part of a diet low in saturated
fats, trans fatty acids and cholesterol.
Safety
This remarkable combination is very
safe for long-term use. Sytrinol is not
diet specific and has no known sideeffects. The Cholesterol Formula can
enhance the performance of cholesterol
lowering drugs such as the statins, and
can be used along with natural cholesterol lowering supplements such as
policosanol, niacin or garlic.
Children: There is no appropriate use at
the present time.
Pregnancy and Lactation: Since the effects
of the Cholesterol Formula have not
been sufficiently evaluated, it should
not be used during those times.
Pre-existing heart conditions: Use this
formula under the direction of their
health care practitioner. Do not stop
taking any prescription medications
that lower cholesterol unless directed by
a health care practitioner.
Beta sitolsterolemia: People with this rare
genetic condition called should not use
any supplements containing plant
sterols.
Anticancer drugs: People on some drugs
such as vinblastine should use products
containing Sytrinol with caution as it
can increase the uptake of the drug as
flavones of orange juice are inhibitors of
P-glycoprotein.
Drug-nutrient interactions: Other than the
above, the Cholesterol Formula can be
safely used with other medications,
including cholesterol-lowering medications. Unlike grapefruit, this formula
does not seem to interfere with the
P450 3A4 pathway through which 60%
of all drugs are metabolized, so is less
likely to have any drug-nutrient
interactions.
Lowering cholesterol naturally and
safely is no longer out of reach. Serious
side-effects no longer need to be a
concern. The Cholesterol Formula with
Sytrinol can be your solution.
Key References
English J., “Novel dietary supplement shows dramatic effects
in lowering cholesterol, LDL, and triglycerides,” Life Extension;
November, 2004
FDA, “FDA authorizes new coronary heart disease health
claim for plant sterol and plant stanol ester,” FDA Talk Paper;
September 5, 2000
Kurowska, E.M., et al., “Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin,” Lipids, Feb, 39 (2): 143-51; 2004
Plant sterol esters/sterols may reduce the risk of heart disease,
VERIS Research Information Service; November 2003
This information is provided for educational purposes only, and is not intended for self-diagnosis or self-treatment of conditions that should be assessed and treated by your
health care practitioner. While the information contained in this document has been carefully reviewed and reflects current clinical and scientific knowledge, it is subject to change.
© All rights reserved – Natural Factors Nutritional Products Ltd. • Enquiries: custservice@naturalfactors.com • 30555 • August 4, 2009 • Pg 2 of 2
Where Great Health Begins