124 (20)

From www.bloodjournal.org by guest on November 20, 2014. For personal use only.
2014 124: e45-3176
124 (20)
Updated information and services can be found at:
http://www.bloodjournal.org/content/124/20.full.html
Articles on similar topics can be found in the following Blood collections
Information about reproducing this article in parts or in its entirety may be found online at:
http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests
Information about ordering reprints may be found online at:
http://www.bloodjournal.org/site/misc/rights.xhtml#reprints
Information about subscriptions and ASH membership may be found online at:
http://www.bloodjournal.org/site/subscriptions/index.xhtml
Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society
of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036.
Copyright 2011 by The American Society of Hematology; all rights reserved.
From www.bloodjournal.org by guest on November 20, 2014. For personal use only.
13 NOVEMBER 2014 x VOLUME 124, NUMBER 20
CONTENTS
COVER FIGURE
Confocal fluorescence micrograph of an in vitro–derived CD1031 dendritic cell
depicting CD103 antibody staining (yellow), phalloidin for F-actin (magenta), and
nucleus counterstain with DAPI (cyan) of a cytospin preparation. The newly
described protocol, termed iCD103, efficiently generates CD1031 dendritic cells
from murine bone marrow. See the article by Mayer et al on page 3081.
INSIDE BLOOD COMMENTARIES
3035
Engraftment’s Holy Grail: is one signal enough?
Majlinda Lako and Lyle Armstrong
Comment on Ramos-Mej´ıa et al, page 3065
3036
How to generate large numbers of CD1031 dendritic cells
Lianne van de Laar and Bart N. Lambrecht
Comment on Mayer et al, page 3081
3038
HiJAKing T-ALL
Vahid Asnafi
Comment on Degryse et al, page 3092
3040
Stress equips CLL cells to survive
Rudi W. Hendriks
Comment on Krysov et al, page 3101
3041
Cautious enthusiasm about GWAS findings
France Gagnon
Comment on Ma et al, page 3155
PERSPECTIVES
3043
Curing myeloma at last: defining criteria and providing the evidence
Bart Barlogie, Alan Mitchell, Frits van Rhee, Joshua Epstein, Gareth J. Morgan,
and John Crowley
HOW I TREAT
3052
How I treat patients with massive hemorrhage
P¨ar I. Johansson, Jakob Stensballe, Roberto Oliveri, Charles E. Wade, Sisse R. Ostrowski,
and John B. Holcomb
CLINICAL TRIALS AND
OBSERVATIONS
3059
Long-term results of first salvage treatment in CLL patients treated initially with
FCR (fludarabine, cyclophosphamide, rituximab)
Constantine S. Tam, Susan O’Brien, William Plunkett, William Wierda, Alessandra Ferrajoli,
Xuemei Wang, Kim-Anh Do, Jorge Cortes, Issa Khouri, Hagop Kantarjian, Susan Lerner,
and Michael J. Keating
HEMATOPOIESIS AND
STEM CELLS
3065
HOXA9 promotes hematopoietic commitment of human embryonic stem cells
Veronica Ramos-Mej´ıa, Oscar Navarro-Montero, Ver´onica Ayll´on, Clara Bueno,
Tamara Romero, Pedro J. Real, and Pablo Menendez
3076
Brief Report
Growth hormone receptor signaling is dispensable for HSC function and aging
Morag H. Stewart, Paula Gutierrez-Martinez, Isabel Beerman, Brian Garrison,
Emily J. Gallagher, Derek LeRoith, and Derrick J. Rossi
xi
BLOOD, 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20
CONTINUED ON xii
From www.bloodjournal.org by guest on November 20, 2014. For personal use only.
e45
e-Blood
Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem
cells in immune-deficient mice
Linping Hu, Hui Cheng, Yingdai Gao, Ming Shi, Yanfeng Liu, Zheng Hu, Jing Xu, Lugui Qiu,
Weiping Yuan, Anskar Yu-Hung Leung, Yong-Guang Yang, and Tao Cheng
IMMUNOBIOLOGY
3081
Selective and efficient generation of functional Batf3-dependent CD1031 dendritic
cells from mouse bone marrow
Christian Thomas Mayer, Peyman Ghorbani, Amrita Nandan, Markus Dudek,
Catharina Arnold-Schrauf, Christina Hesse, Luciana Berod, Philipp St¨uve, Franz Puttur,
Miriam Merad, and Tim Sparwasser
LYMPHOID NEOPLASIA
3092
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell
acute lymphoblastic leukemia in a mouse model
Sandrine Degryse, Charles E. de Bock, Luk Cox, Sofie Demeyer, Olga Gielen, Nicole Mentens,
Kris Jacobs, Ellen Geerdens, Valentina Gianfelici, Gert Hulselmans, Mark Fiers, Stein Aerts,
Jules P. Meijerink, Thomas Tousseyn, and Jan Cools
3101
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded
protein response dependent on BTK and SYK
Sergey Krysov, Andrew J. Steele, Vania Coelho, Adam Linley, Marina Sanchez Hidalgo,
Matthew Carter, Kathleen N. Potter, Benjamin Kennedy, Andrew S. Duncombe,
Margaret Ashton-Key, Francesco Forconi, Freda K. Stevenson, and Graham Packham
3110
Differential and limited expression of mutant alleles in multiple myeloma
Naim U. Rashid, Adam S. Sperling, Niccolo Bolli, David C. Wedge, Peter Van Loo, Yu-Tzu Tai,
Masood A. Shammas, Mariateresa Fulciniti, Mehmet K. Samur, Paul G. Richardson,
Florence Magrangeas, Stephane Minvielle, P. Andrew Futreal, Kenneth C. Anderson,
Herve Avet-Loiseau, Peter J. Campbell, Giovanni Parmigiani, and Nikhil C. Munshi
3118
FOXO1 repression contributes to block of plasma cell differentiation in classical
Hodgkin lymphoma
Marion J. Vogel, Linka Xie, Hanfeng Guan, Reuben M. Tooze, Thomas Maier, Ulrike Kostezka,
Harald J. Maier, Karlheinz Holzmann, Fong Chun Chan, Christian Steidl, Jonathan B. Reichel,
Clarissa D. Weitzer, Franziska Gehringer, Anita B. Kick, Ethel Cesarman, Mikhail Roshal,
Randy D. Gascoyne, Peter M¨oller, Thomas Wirth, and Alexey Ushmorov
MYELOID NEOPLASIA
3130
The TAK1-NF-kB axis as therapeutic target for AML
Matthieu Cornelis Johannes Bosman, Hein Schepers, Jennifer Jaques,
Annet Zwaantien Brouwers-Vos, Wim Johannes Quax, Jan Jacob Schuringa, and Edo Vellenga
PLATELETS AND
THROMBOPOIESIS
3141
Interaction of platelet-derived autotaxin with tumor integrin aVb3 controls
metastasis of breast cancer cells to bone
Raphael Leblanc, Sue-Chin Lee, Marion David, Jean-Claude Bordet, Derek D. Norman,
Renukadevi Patil, Duane Miller, Debashish Sahay, Johnny Ribeiro, Philippe Cl´ezardin,
Gabor J. Tigyi, and Olivier Peyruchaud
RED CELLS, IRON, AND
ERYTHROPOIESIS
3151
Brief Report
Cell-type–specific transcriptional regulation of PIGM underpins the divergent
hematologic phenotype in inherited GPl deficiency
Joana R. Costa, Valentina S. Caputo, Kalliopi Makarona, D. Mark Layton,
Irene A. G. Roberts, Antonio M. Almeida, and Anastasios Karadimitris
xii
BLOOD, 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20
CONTINUED ON xiv
From www.bloodjournal.org by guest on November 20, 2014. For personal use only.
THROMBOSIS AND
HEMOSTASIS
3155
Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to
plasma plasminogen levels
Qianyi Ma, Ayse B. Ozel, Shweta Ramdas, Beth McGee, Rami Khoriaty, David Siemieniak,
Hong-Dong Li, Yuanfang Guan, Lawrence C. Brody, James L. Mills, Anne M. Molloy,
David Ginsburg, Jun Z. Li, and Karl C. Desch
3165
Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term
primate model of acquired hemophilia A
Atsushi Muto, Kazutaka Yoshihashi, Minako Takeda, Takehisa Kitazawa, Tetsuhiro Soeda,
Tomoyuki Igawa, Zenjiro Sampei, Taichi Kuramochi, Akihisa Sakamoto, Kenta Haraya,
Kenji Adachi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, and Kunihiro Hattori
3172
Brief Report
In vitro evidence of a tissue factor-independent mode of action of recombinant
factor VIIa in hemophilia
Cecilia Augustsson and Egon Persson
BLOOD WORK
3175
Small-cell variant of ALK1 anaplastic large-cell lymphoma with a leukemic phase
Huifei Liu and Shafinaz Hussein
3176
Granular lymphoid cells are not always part of T-cell lineage: an atypical case of
mantle cell lymphoma
Emmanuel Benayoun and Orianne Wagner-Ballon
OTHER DEPARTMENTS
iib
Classifieds
SUBMISSION INSTRUCTIONS
All manuscripts, including figures, should be submitted electronically at
http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your
paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/
authorguide.xhtml. If you need help during the submission process, contact the Editorial Office by
phone at 202-776-0548 or via e-mail at editorial@hematology.org.
xiv
BLOOD, 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20