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Séminaires et autres manifestations sur Paris Ile de France : semaine du lundi 01 au vendredi 05 décembre 2014
Date
Unité
Titre
Heure
Section NEUROSCIENCES
Bernd Fakler
Institute of Physiology, Freiburg
Native AMPA receptors - molecular appearance and operation from functional
proteomics
Lundi 01
11h00
Salle Favard
Invité(e) par : Pierre PAOLETTI - Section NEUROSCIENCES
http://www.ibens.ens.fr/spip.php?evenement266
Institut de Biologie de l’École
Salle Favard
Normale Supérieure
En savoir plus : http ://www.ibens.ens.fr/spip.php ?evenement197
46, rue d’Ulm
Paris 5ème
David KATZ
Department of Cell Biology, Emory University, Atlanta
The histone demethylase LSD1 regulates cell fate and prevents neurodegeneration
Amphithéâtre Curie
14h00
Invité(e) par : Sonia GAREL - Section BIOLOGIE DU DEVELOPPEMENT
En savoir plus : http://www.ibens.ens.fr/spip.php?evenement256
http://www.biologie.upmc.fr/fr/recherche/les_seminaires.html
Page 1
Date
Unité
Titre
Heure
Dr Cyril Hanus,
MPI Frankfurt
Collège de France – Centre
Interdisciplinaire de
Recherche en Biologie
Unconventional secretory processing diversifies neuronal ion channel properties
11, Place Marcelin Berthelot –
75231 Paris Cedex 05
invité par A. Prochiantz
au Collège de France - Salle de conférence D2
11h30
En savoir plus : http ://www.college-de-France.fr/site/encirb/centre_interdisciplinaire_d__1.htm#|p=../en-cirb/centre_interdisciplinaire_d__1.htm|
Anthony DEFRANCO
Professor of Microbiology and Immunology, University of California, San Francisco
Lundi 01
Contribution of TLRs in B cells to the germinal center response in health and disease
Centre de Recherche - Paris - Amphithéâtre Antoine Lacassagne
Institut Curie
26, rue d’Ulm Paris 5ème
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating
inflammation and also for promoting adaptive immune responses. While initial work suggested that TLR stimulation of
B cells promotes an extrafollicular antibody response, which is responsible for rapid production of moderate affinity
antibodies, we have found that TLR9 can strongly enhance the germinal center response, which produces high affinity
class-switched antibody made by long-lived plasma cells. In particular, the B cell responds strongly to a combination of
a particulate antigen with repetitive epitopes and the presence of a TLR9 or TLR7 ligand attached to the particle. B cells
stimulated in this way rapidly outcompete B cells in germinal centers that cannot signal via their TLRs due to deletion of
the signaling component MyD88. These B cells exhibit enhanced affinity maturation. In addition, B cells stimulated in
this way enhance the response of follicular helper T cells. This pathway appears to be important not only for making
high affinity antibodies against infecting viruses, but also in making the anti-nuclear antibodies that are characteristic of
human lupus.
14h30
En savoir plus : https://seminars.curie.fr/seminaire/index.php?id=874
Page 2
Date
Unité
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Heure
01 décembre 2014 : Colloque Médecine Personnalisée et Cancérologie
Institut de Cancérologie
Gustave Roussy
39, rue Camille Desmoulins 94805
Villejuif
Lieu : Espace CARDIN à Paris
Renseignements et inscription : colloque-cancer-medecine-personnalisee.sante-idf.fr
En savoir plus : http://www.gustaveroussy.fr/index.php?p_a=agenda&p_agenda=3
01 décembre 2014 - 04 décembre 2014 : Rencontres de la cancérologie française 2014
Lundi 01
Lieu : Espace CARDIN, Paris
Gustave Roussy
Villejuif
Renseignements et inscription : www.rcfr.eu
Contact : Fabienne Balatre
Page 3
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Unité
Titre
Heure
DR. FÉDOR BERDITCHEVSKI,
THE UNIVERSITY OF BIRMINGHAM (UK)
TETRASPANIN PROTEINS: FROM MEMBRANE MICRODOMAINS TO REGULATION OF
METASTATIC PROGRESSION IN CANCER
HÔPITAL PAUL-BROUSSE, BÂTIMENT UNIV. ANDRÉ LWOFF - RDC, 12-14 AVENUE PAUL VAILLANTCOUTURIER, 94800 VILLEJUIF
INVITÉ PAR ERIC RUBINSTEIN, UMR-S 1004 INSERM/P11
Lundi 01
Institut André Lwoff
Bât. Lavoisier
Hôpital Paul Brousse
12-16 ave. Paul Vaillant-Couturier
94800 Villejuif
ABSTRACT:
Tetraspanins represent a large group of four transmembrane domain proteins with diverse biological function:
tetraspanins are known to regulate egg-sperm fusion, host immune responses, tumour development and cancerous
progression. At the biochemical level tetraspanins organise distinct microdomains on the plasma membrane which also
include transmembrane receptors and cytoplasmic signaling proteins. Within these microdomains tetraspanins function
along lateral and horizontal signaling axes by coordinating signaling pathways from various cell surface receptors thus
controlling cellular responses to extracellular stimuli. Tetraspanin microdomains are used by a variety of pathogens
during their life cycle. They have an important role in the uptake, trafficking and spread of viruses (e.g. hepatitis C virus,
human papillomaviruses) as well as intracellular bacteria, fungi and parasites.
11h30
Deregulated expression of various tetraspanins is also linked to the metastatic progression and poor prognosis in
various types on cancer. At the cellular level tetraspanins control proliferation and migration of tumour cells and their
interaction with microenvironment. Importantly, tetraspanins and their molecular partners can also modulate cellular
responses to drugs used in cancer thérapies.
The presentation will combine two parts: - the role of tetraspanin complexes in the life cycle of human
papillomaviruses; - the role of tetraspanin-integrin complexes in regulation of responses of breast cancer cells to growth
factors and drugs that target receptor tyrosine kinases.
_VENEZ NOMBREUX : __Merci d'avance de votre présence ......_.
À très bientôt,
Page 4
Date
Unité
Titre
Heure
SFR Necker
REGOIRE MICHAUX –
Inserm US 24 CNRS UMS 3633 G
Institut de Génétique et Développement de Rennes
Faculté Paris Descartes
Lundi 1
Bâtiment Leriche Porte 14
Epithelial cell polarity and membrane traffic: from C. elegans to rare intestinal genetic 13h00
14 rue Maria Helena Vieira Da disorders
Silva
Institut des maladies génétiques IMAGINE - Auditorium 6ème étage - 24, bd du Montparnasse 75015 Paris
CS 61431
En savoir plus : http://www.necker.fr/sfr-necker/index.php?menu=seminar
75993 Paris cedex 14
Page 5
Date
Unité
Titre
Heure
Meeting : DIM Cerveau Pensee de 9h00 à 19h00
Amphi F - Faculté Pierre et Marie Curie
105 Bld de l'Hopital
75013 paris
ICM, Institut du Cerveau
et de la Moelle épinière
Hôpital Pitié Salpêtrière
47 / 83, bd de l’hôpital
75013 PARIS
This meeting aims to promote exchanges in the field of neuroscience in all its diversity. It allows
doctoral students and researchers to present their work and the new implemented
technologies (morning devoted to the Region Ile-de-France contributions). The afternoon will
be devoted to discussions around educational sciences. The meeting will end with an artistic
event
Program : http://dimcerveaupensee.fr/sites/default/files/programme%20Colloque%20DIM%202.pdf
Mardi 2
Registration form :
https://docs.google.com/forms/d/1qOJMm_6L6eudlocfY6hptuc4xq4luvMMGfqs29bVMew/viewform
Séminaire de l’Institut
Institut Cochin,
Faculté de Médecine,
24 rue du Fbg St Jacques,
75014 Paris
Edouard Bertrand
IGMM, Montpellier
RNA processing and localization: role of the cap in the nucleus and diversity of mRNA
localization phenotypes in the cytoplasm
14h00
Salle Schapira (2017), 2e étage
En savoir plus : http://cochin.inserm.fr/linstitut/seminaires/copy44_of_modele-ic-1
Page 6
Date
Unité
Titre
Heure
Marie DEWANNIEUX
Institut Gustave Roussy
Institut Curie
Molecular virology of human endogenous retrovirus HERV-K(HML2): amplification
mechanism and regulation
References: The HERV-K Human Endogenous Retrovirus Envelope Protein Antagonizes Tetherin
Antiviral Activity. Lemaître C, Harper F, Pierron G, Heidmann T, Dewannieux M. J Virol. 2014 Dec
1;88(23):13626-37. doi: 10.1128/JVI.02234-14. Epub 2014 Sep 10. The mouse IAPE endogenous...
11h00
En savoir plus : https://seminars.curie.fr/seminaire/index.php?id=876
Mardi 2
UMR8256 B2A, Adaptation
Biologique et Vieillissement,
Equipe Développement,
Réparation et Vieillissement
Cérébral,
Université Pierre et Marie
Curie,
9 Quai St Bernard,
75005, Paris
Dr Jennifer RODGER,
Associate Professor, School of Animal Biology, University of Western Australia.
Low intensity magnetic stimulation of the brain: evidence for reorganisation of neural 12h30
circuits and frequency specific effects
Jussieu Bat B 5eme étage B501
Département de Biologie Cellulaire et Infection
Institut Pasteur
25,28 rue du Docteur Roux
Paris 15ème
Michael STARNBACH
Department of Microbiology and Immunobiology - Harvard Medical School Boston USA
Chlamydia trachomatis alters host immunity and host cells
12h00
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod
En savoir plus : http ://www.pasteur.fr/conferences/Conferences.do
Page 7
Date
Unité
Titre
Heure
Le 2 décembre 2014 : "Hommage à Maurice Tubiana"
Séance commune Académie des sciences-Académie nationale de médecine
À partir de 14h à l'Académie nationale de médecine –
Mardi 2
Académie des Sciences
23, quai de Conti – 75006
Paris
Sur inscription : sandrine.chermet[at]academie-sciences.fr
Voir le programme : http://www.academie-medecine.fr/wp-content/uploads/2014/09/2.12.14-hommageM.Tubiana.pdf
En savoir plus : http ://www.academie-sciences.fr/activite/conf.htm
Page 8
Date
Unité
Titre
Heure
Mercredi 3
03 décembre 2014 - 05 décembre 2014 :
Gustave Roussy
31ème Congrès de la Société Française de Psycho-Oncologie
Villejuif
Le 31ème Congrès de la SFPO aura pour thème "Entre épuisement et satisfaction au travail : soigner en
cancérologie"
Lieu : Palais des congrès et de la culture, Le Mans
Renseignements et inscription : congres-sfpo.comm-sante.com
Mail : congres-sfpo@comm-sante.com
Page 9
Date
Unité
Titre
Heure
Section Génomique Environnementale et Évolutive
Célia BAROUX
University of Zurich, Institute of Plant Biology, Switzerland
Chromatin dynamics when plant cells change their fate : driver or readout ?
Normale Supérieure
IBENS - Salle Favard
11h00
Invité(e) par : Frédy BARNÈCHE
En savoir plus : http ://www.ibens.ens.fr/spip.php ?evenement189
Mercredi 3
Soutenance de thèse - 14h - Salle Multimédia 2 (4023), 4ème étage de la Faculté de Médecine de Créteil.
Université Paris Est Créteil
Val de Marne Institut Mondor de
Recherche Biomédicale
(IMRB)
Inserm U955- Groupe Hospitalier
Universitaire Albert Chenevier Henri Mondor
51 av du Maréchal de Lattre de
Tassigny
94010 Créteil
Sandra Chrusciel
IMRB-U955, équipe 4)
Rôle de p53 dans les macrophages en réponse à diverses agressions environnementales
Directeurs de thèse : Jorge Boczkowski et Laurent Boyer
En savoir plus : http://www.imrb.u-pec.fr/seminaires/seminaires-250224.kjsp
Page 10
Date
Unité
Titre
Heure
Célia BAROUX
University of Zurich, Institute of Plant Biology, Switzerland
Chromatin dynamics when plant cells change their fate : driver or readout ?
IBENS - Salle Favard
Normale Supérieure
46, rue d’Ulm Paris 5
11h00
ème
Invité(e) par : Frédy BARNÈCHE - Section GENOMIQUE ENVIRONNEMENTALE ET EVOLUTIVE
En savoir plus : http://www.ibens.ens.fr/spip.php?evenement267
Cécile BOUSQUET-ANTONELLI
Mercredi 3
Laboratoire de Biologie du
Développement
9 quai St Bernard, Bat C, 7ème étage
Paris 5ème
Institut de Biologie Paris
Seine (IBPS)
Quai Saint Bernard
75005 Paris
Un nouveau mécanisme de dégradation des ARNm induit par le stress thermique chez
Arabidopsis thaliana
Auditorium - C7
12h00
En savoir plus :
http://bio-dev.snv.jussieu.fr/umr7622/seminaire/seminaire.php?lang=fr&dossier=seminaire&page=seminaire
Cécile Bousquet-Antonelli,
Laboratoire Génome et Développement des Plantes,Université de Perpignan
Un nouveau mécanisme de dégradation des ARNm induit par le stress thermique chez
Arabidopsis thaliana
12h00
Auditorium C7 (Bâtiment C, 7ème étage)
En savoir plus : http://www.ibps.upmc.fr/fr/actus/evenements
Page 11
Date
Unité
Titre
Heure
Olga Sokolova
Moscow State University
Structural study of actin disassembly
bibliothèque du laboratoire - 2ème étage
A few references related to her work on actin:
Jansen S, Collins A, Golden L, Sokolova O, Goode BL. Structure and Mechanism of Mouse Cyclaseassociated Protein (CAP1) in Regulating Actin Dynamics. J Biol Chem. 2014 Oct 31;289(44):30732-42.
Mercredi
03
Ydenberg CA, Padrick SB, Sweeney MO, Gandhi M, Sokolova O, Goode BL. GMF severs actin-Arp2/3
Laboratoire d'Enzymologie et complex branch junctions by a cofilin-like mechanism. Curr Biol. 2013 Jun 17;23(12):1037-45.
Biochimie Structurales (LEBS) Chaudhry F, Breitsprecher D, Little K, Sharov G, Sokolova O, Goode BL. Srv2/cyclase-associated
Centre de Recherche de Gif - protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin. Mol Biol
CNRS
Cell. 2013 Jan;24(1):31-41.
Bâtiment 34 - Avenue de la
Maiti S, Michelot A, Gould C, Blanchoin L, Sokolova O, Goode BL. Structure and activity of full-length
Terrasse
formin mDia1. Cytoskeleton (Hoboken). 2012 Jun;69(6):393-405.
91190 Gif-sur-Yvette
Sinitsina N, Orshansky I, Sokolova O. Actin-binding proteins: how to reveal the conformational
changes. J Bioinform Comput Biol. 2008 Aug;6(4):869-84.
11h00
Rodal AA, Sokolova O, Robins DB, Daugherty KM, Hippenmeyer S, Riezman H, Grigorieff N, Goode BL.
Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol. 2005
Jan;12(1):26-31.
Invitée par A. Gautreau
http://www.lebs.cnrs-gif.fr/fr/component/content/article/42-seminaires/294sokolova.html?Itemid=140
Page 12
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Le 3 décembre prochain, il y aura 2 séminaires à Bioger :
de 10h à 11h : Induced resistance by biochar - Yigal Elad
de 11h à 12h : Molecular analysis of grapevine stress responses - Melané Vivier
Vous trouverez ci-dessous le résumé de chacune de ces présentations.
Induced resistance by biochar - Yigal Elad
Department of Plant Pathology and Weed Research, Institute of Plant Protection, The Volcani Center, Agricultural
Research Organization, Bet Dagan 50250, Israel
Mercredi
03
Institut de Biologie des
Plantes
Plateau du Moulon de
l’Université Paris sud
Rue Noetzlin
Bâtiment 630
91405 Orsay
Biochar is generated from waste via a pyrolysis process (thermal breakdown in the absence of oxygen), and it can be
added to soil to achieve long term carbon sequestration. Biochar is stabile in the environment and have been seen to
cause a wide range of positive impacts on plant development and soil tilth when added to the growing medium One
intriguing impact of biochar addition to soil is its ability to improve plant resistance to diseases caused by pathogens.
Biochar amendment of the soil was shown to reduce diseases caused by the soilborne pathogen Rhizochtonia and
Pythium and has also been found to induce or mediate the induction of system-wide plant resistance to diseases caused
by various foliar pathogens that employ a range of infection strategies (necrotrophic, biotrophic, and semi-biotrophic),
and where no part of the pathogen life cycle is in the soil. Severity of disease caused by powdery mildew (Oidiopsis
taurica) and grey mould (Botrytis cinerea) in tomato and pepper plants decreased significantly biochar was applied to the
potting mixture. In strawberry, biochar amendment significantly suppressed diseases caused by B. cinerea, Colletotrichum
acutatum (anthracnose), and Podosphaera apahanis (powdery mildew), and caused an up-regulation of defense-related
genes both before and after infection. O. taurica was controlled in commercially grown sweet pepper and peepr yield was
significantly increased.
Biochar-mediated IR could be due to chemical and/or biological components such as low-level stress-exerting phytotoxic
compounds contained in the biochar, or biochar-induced plant growth promoting rhizobacteria and fungi. In support of
these hypotheses, priming of defense-related genes’ expression along both SAR and ISR pathways in strawberry upon
infection by B. cinerea and P. apahanis due to biochar amendment has been found. In tomato mutants with genetic
variations affecting salicylic acid (SA), ethylene (ET) or jasmonic acid (JA) pathways, biochar amendment induced priming
of early as well as late-acting defence responses particularly in the genes Pti5 (ET-related) and Pi2 (JA-related), which are
known to be crucial in resistance against B. cinerea. Stronger and earlier H2O2 accumulation was observed as a result of
the biochar amendment subsequent to B. cinerea inoculation in all genotypes, and this effect was disrupted by the def1
mutation. Thus, biochar-mediated IR in the B. cinerea-tomato pathosystem involves the JA pathway.
The lecture will present the research under controlled greenhouse, field and laboratory conditions linking the mode of
action with actual field performance of disease reduction and yield increase.
10h00
En savoir plus : http://www.ibp.u-psud.fr/spip.php?article223
Page 13
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Molecular analysis of grapevine stress responses - MA Vivier
Institute for Wine Biotechnology, Dept. of Viticulture and Oenology, Stellenbosch University, South
Africa- Email : mav@sun.ac.za
Mercredi
03
Institut de Biologie des
Plantes
Plateau du Moulon de
l’Université Paris sud
Rue Noetzlin
Bâtiment 630
91405 Orsay
Vitis vinifera (grapevine) is the most important fruit-bearing crop globally. It is a non-model, woody
perennial plant that has been shown to be adaptable to a variety of environments. Since the
sequencing of its genome, this species has been increasingly studied with omics-tools, leading to a
deeper understanding of important developmentally-controlled processes, as well as phenotypic
plasticity linked to environmental impacts and stresses. The inherent variability of vineyards and the
limitations it poses on the application of omics tools to vines in vineyards have necessitated
conceptual changes to grapevine field studies, leading to the concept of model vineyards and “fieldomics”. Molecular and metabolite profiling experiments were conducted in (model) vineyards to
follow the impacts of various environmental stresses, leading to new information regarding the
response of grapevines, as well as its implications in managing the stress. In addition to the fieldomics approach, molecular analysis of grapevine stress responses through functional analysis of
grapevine genes and/or pathways have shown that although significant overlap exists between
pathways used for abiotic and biotic stresses, the initial recognition of the stresses is unique to the
specific stress. Both environmental and biotic stresses (excessive light, temperature and infections,
respectively) have been shown to impact the terpenoid pathway in different grapevine organs,
leading to the production of specialised volatile organic compounds as signals or effectors, depending
on the situation. Similarly, the cell wall has been shown to be modulated by a range of stresses, using
different triggers, but similar mechanisms to modulate this dynamic region. Our results will be
discussed in light of the important current questions and opportunities in grapevine biology.
11h00
En savoir plus : http://www.ibp.u-psud.fr/spip.php?article223
Page 14
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Prof Yves BLERIOT
Université de Poitiers
Institut de Chimie des
Substances Naturelles
Avenue de la Terrasse
91190 GIF-SUR-YVETTE
Utilisation de conditions superacides en chimie des sucres
Amphithéâtre de l'ICSN
11h00
En savoir plus : http://www.icsn.cnrs-gif.fr/spip.php?rubrique12
Séminaire de l’institut
Jeudi 04
Institut Cochin,
Faculté de Médecine,
24 rue du Fbg St Jacques,
75014 Paris
Bin Li
Institut Pasteur, Shanghai, Chine)
Ubiquitination-mediated regulation of FOXP3 and RORgt and the balance of Treg and
Th17 under inflammation
12h00
Salle de conférence, 2ème étage 22 rue Méchain 75014 Paris
En savoir plus : http://cochin.inserm.fr/linstitut/seminaires/BinLi
Page 15
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Heure
Gustave Roussy
Villejuif
Jeudi 04
Le 31ème Congrès de la SFPO aura pour thème "Entre épuisement et satisfaction au travail :
soigner en cancérologie".
Gustave Roussy
Villejuif
Page 16
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Unité
Titre
04 décembre 2014 - 05 décembre 2014 : 15èmes Journées du GPCO
Gustave Roussy
Lieu : Maison de l’Economie, Besançon
Villejuif
Renseignements et inscription : congres-gpco.fr
Heure
Zena WERB
Professor and Vice-Chair of Anatomy at the University of California, San Francisco (USA).
Jeudi 04
Molecular Mechanisms Regulating Metastasis in Breast Cancer
This conference is jointly organised by the Institut Curie and the Institut Servier.
Institut Curie
26, rue d’Ulm Paris 5
ème
11h00
Télécharger l’affiche : https://seminars.curie.fr/web/upload/seminaire/seminar_000836_fr.pdf
En savoir plus : https://seminars.curie.fr/index.php?seminaire_item=20
Page 17
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Département Génomes et Génétique
Clément GILBERT
Université de Poitiers - CNRS UMR 7267, Laboratoire Ecologie et Biologie des Interactions
Horizontal transfer of genetic material between viruses and their animal hosts
Salle Jean-Paul Aubert, rdc du bâtiment Fernbach
Jeudi 04
Institut Pasteur
Paris 15ème
Abstract:
Host-virus interactions involve a high level of promiscuity between viral and host genomes, favoring
transfer of genetic material both in the virus-to-host and host-to-virus directions. Well known
examples of such transfers include the large contribution of retroviral genes to vertebrate genomes
and the capture and domestication of many host genes by nucleo-cytoplasmic large DNA viruses.
Here I will present our latest results on these types of transfers in animals, showing how the study of
ancient non-retroviral endogenous viruses furthers our understanding of the biology and evolution of
current viral families, and shedding light on the frequency and mechanisms underlying host-to-virus
transfers at the microevolutionary scale
11h00
En savoir plus : http://www.pasteur.fr/conferences/Conferences.do
Page 18
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Séminaire du département des Parasites et Insectes Vecteurs
Hernando DEL PORTILLO
CRESIB - Barcelona Centre for International Health Research - Hospital Clínic - Universitat de
Barcelona - Barcelone – Espagne
Reticulocyte-derived exosomes as new conveyers of spleen-dependent protective
immune responses in malaria
Institut Pasteur
Paris 15ème
12h00
Salle 014-015, rdc du bâtiment Lwoff
Gérard SPAETH
Unité de Parasitologie moléculaire et Signalisation
Jeudi 04
Alien versus Predator: Mechanisms of Leishmania intra-macrophagic survival
Grand Amphithéâtre de l'Institut Pasteur, bâtiment Duclaux
16h30
Fernando Arenzana Seisdedos
Institut Pasteur, Paris
Faculté de médecine René
Descartes
15 rue de l’École de Médecine
75006 Paris
Gates and Ways of HIV entry
Salle de conférence
11h00
En savoir plus : http://www.biomedicale.parisdescartes.fr/Les-seminaires-a-venir.html
Page 19
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INC Day 2014 de 9h à 18h00
Université de médecine Paris
Neurodevelopmental Disorders
DESCARTES
Salle du Conseil
12, rue de l’école de
Université Paris Descartes 12 rue de l'Ecole de Medecine 75006 Paris
médecine
75006 Paris
Programme : http://www.dimcerveaupensee.fr/sites/default/files/affiche_inc_day_2014_.pdf
En savoir plus : http://meconf.org/index.html
Jeudi 4
Paul Gepts,
University of California, Davis
invité par Thierry Robert
Laboratoire Evolution
Génomes et Spéciation
Campus CNRS Gif sur Yvette
Analyse moléculaire de la détermination caulinaire chez le haricot – Origines multiples 12h00
d’un caractère de domestication
Salle de Conférence, Bâtiment 360, Orsay
en savoir plus : http://www.legs.cnrs-gif.fr/seminaire.php
Page 20
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Prof. Michael Granato
Department of Cell & Developmental Biology, Perelman School of Medicine, University of
Pennsylvania, USA
Invité par Alain Chédotal
Jeudi 4
Institut de la Vision
17 rue Moreau - 75012 Paris
Seeing is believing: cellular and molecular analysis of axonal regeneration
11h30
En savoir plus : http://www.institutvision.org/index.php?option=com_content&view=article&id=172%3Aseminaires&catid=2%3Ainstitut
-de-la-vision&Itemid=49&lang=fr
Page 21
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Guichard, Paul, Dr. –
Swiss Federal Institute of Technology (EPFL) Swiss Institute for Experimental Cancer Research (ISREC)
Lausanne, Switzerland
Towards a molecular architecture of centriole
Salle de conférences, Bât. 24
Abstract:
Vendredi
05
Centre de Génétique
Moléculaire
Gif-sur-Yvette
the centriole and the related basal body is a macromolecular structure that is fundamental for the assembly of cilia and
flagella across evolution. Moreover, the centriole is required for the assembly of the centrosome, the principal microtubuleorganizing center (MTOC) of animal cells and cilia in most of Eukaryotes. Centrioles are evolutionarily conserved
microtubule-based cylindrical macromolecular structures that in human cells are 500 nm long and 230 nm in outer
diameter. Centrioles are characterized by the presence of nine triplets of microtubules surrounding a cartwheel structure
at their proximal end, which is critical for imparting the 9-fold symmetry of the entire structure. We recently showed that
the evolutionary conserved SAS-6 proteins, essential for cartwheel assembly and forming a 22nm ring in vitro, is likely to
form a ring in vivo, as revealed by the 50A resolution 3D map of the cartwheel from Trichonympha, a symbiotic flagellate
present in the hindgut of termites. Although this work uncovered the cartwheel architecture, how it connects to the
peripheral microtubules is not understood. More generally, a comprehensive structural view of the proximal region of the
centriole is lacking, thus limiting understanding of the underlying centriolar assembly mechanisms.
14h30
Using cryotomography and sub-tomogram averaging, we report the complete architecture of the Trichonympha centriole
proximal region. The resulting 3D map at 38A resolution reveals several features, including additional densities in the
cartwheel that exhibit a 9-fold symmetrical arrangement, as well as the structure of the Pinhead and the A-C linker that
connect to microtubules. Moreover, we uncover striking chiral features that might impart directionality to the entire
centriole. Furthermore, we identify Trichonympha SAS-6 and demonstrate that it localizes to the cartwheel in vivo.
Our work provides unprecedented insight into the architecture of the centriole proximal region, which is key for a
thorough understanding of the mechanisms governing centriole assembly.
Invité par Anne-Marie Tassin
Pour en savoir plus : http://www.cgm.cnrs-gif.fr/spip.php?article292
Page 22
Date
Unité
Titre
Heure
Le 31ème Congrès de la SFPO aura pour thème "Entre épuisement et satisfaction au
travail : soigner en cancérologie".
Gustave Roussy
Villejuif
Vendredi
05
04 décembre 2014 - 05 décembre 2014 : 15èmes Journées du GPCO
Gustave Roussy
Lieu : Maison de l’Economie, Besançon
Villejuif
Renseignements et inscription : congres-gpco.fr
Page 23
Date
Unité
Titre
Heure
47ème congrès de la Société Française de Carcinologie Cervico-Faciale
Lieu : Le Corum, Montpellier
Gustave Roussy
Villejuif
Renseignements et inscription : sfccf2014.org
Contact : Com & Co - Etienne Jarry - ejarry@comnco.com
Vendredi
05
Jean-Sébastien HULOT
UMRS 1166 - ICAN
Centre de Recherche des
Cordeliers
15 rue de l’Ecole de médecine,
Paris 6ème
IPS
amphithéâtre Gustave Roussy
12h00
Pour en savoir plus : http://www.crcjussieu.fr/crc/index.php?cible=actualite&id=551
Page 24
Date
Unité
Titre
Heure
Séminaire de l'Institut
Arezki BOUDAOUD
Laboratoire de Reproduction et Développement des Plantes, Mécanique de la morphogénèse, Ecole
Normale Supérieure de Lyon
Institut Jacques Monod
Bât. Buffon - 15 rue Hélène Brion
invité par Nicolas Minc
11h45
From stochastic cell behaviour to reproducible morphogenesis ?
Salle des séminaires de l'Institut Jacques Monod (Aile B - RdC bas)
Vendredi
05
En savoir plus : http://www.ijm.fr/ijm/seminaires-et-colloques/
Raphaël Mercier,
IJPB, INRA Versailles
Laboratoire Evolution
Génomes et Spéciation
Campus CNRS Gif sur Yvette
invité par Matthieu Falque
Several mechanisms limit meiotic crossovers
11h00
Salle de Conférence du Moulon
en savoir plus : http://www.legs.cnrs-gif.fr/seminaire.php
Page 25
Date
Unité
Titre
Heure
JEAN PAUL BORG –
CRCM Marseille
Institut Fédératif de
Recherche Necker-Enfants
malades
Erbin et polarité cellulaire
Faculté Paris Descartes, Inserm U 1151 - Site Broussais - Amphithéâtre Leriche - Porte 10 - 14 rue
Maria Helena Vieira Da Silva - 75014 Paris
12h00
149 rue de Sèvre - Tour Lavoisier 7
75743 Paris CEDEX 15
Invité(e) par Vincent Goffin
UFR5 Biomédicale des Saints Pères
Rui Costa
Champalimaud Neuroscience Program, Champalimaud Center for the Unknown, Lisbon Portugal
Vendredi
05
Generating and shaping novel action repertoires
Salle des Conférences (R229) Centre Universitaire des Saints-Pères 45 rue des Saints-Pères, 75006 Paris
Faculté de médecine René
Descartes
15 rue de l’École de Médecine
75006 Paris
Some actions are innate or prewired (such as swallowing or breathing). Others are learned anew
throughout life, likely through a process of trial and feedback. We used electrophysiology, imaging
and optogenetics in behaving animals to understand how novel self-paced actions are generated, and
how specific actions that lead to particular outcomes are then selected. We uncovered that
dopamine is critical for the generation of novel actions, and that plasticity in cortico-basal ganglia
circuits is necessary for action selection. Furthermore, as actions are shaped they become organized
into chunks, and neural substrates of parsing and concatenation of motor chunks emerge in basal
ganglia circuits.
11h30
En savoir plus : http://www.biomedicale.parisdescartes.fr/Les-seminaires-a-venir.html
Page 26
Date
Unité
Titre
Heure
Séminaire Visiteur
Dr. Stéphane HERBETTE et Eric BADEL
(Physique et Physiologie de l’Arbre Fruitier et Forestier (PIAF), INRA-Université Blaise Pascal,
Clermont-Ferrand)
Du gène à l'anatomie fonctionnelle du xylème : approches et outils développés au PIAF
Grande salle Bât. 7
Institut Jean-Pierre BOURGIN
Route de Saint-Cyr
78026 Versailles Cedex France
Invités par Mylène Durand-Tardif
9h30
Contact : Mylene.Durand-Tardif@versailles.inra.fr
Affiche : http://wwwijpb.versailles.inra.fr/fr/institut/fichiers/Affiche_seminaire_visiteur_IJPB_Stephane_Herbette_Eric_Ba
del_05-12-2014.pdf
Vendredi
05
En savoir plus :
http://www.ibp.u-psud.fr/IMG/docx/Affiche_seminaire_IJPB_AndreasWeber_22022013.docx
Jesper Vuust MØLLER
Aarhus University, Denmark
Service de Bioénergétique,
Biologie Structurale et
Mécanismes
CNRS UMR 8221
CEA/Saclay IBITEC-S
Thapsigargin analogues, their interactions with SERCA and cancer cells
Bât. 532 P. 204
11h00
En savoir plus :
Résumé : http://3bio.saclay.org/summary.cgi?2014120511
Page 27
Date
Unité
Titre
Heure
Séminaire IDEEV à l'UMR de Génétique Végétale
Raphaël MERCIER
IJPB, Inra Versailles-Grignon
Several mechanisms limit meiotic crossovers
Ferme du Moulon - Salle de conférences
Invité par Matthieu Falque
Résumé
Vendredi
05
UMR de GÉNÉTIQUE
VÉGÉTALE
INRA/Univ. Paris Sud/CNRS
Ferme du Moulon
91190 Gif-sur-Yvette, France
Meiotic crossovers generate genetic diversity by creating new allelic combinations. Intriguingly the
meiotic crossover rates are restricted within a very narrow range. A minimum of one crossover is
formed per pair of homologous chromosomes per meiosis. This "obligate" crossover ensures correct
segregation of the homologs at the first division leading to balanced gametes and ultimately favors
fertility of an organism. Crossover frequency does not typically vary above of the range of one to four
crossovers per homologous pair. A great deal has been discovered about how meiotic crossovers are
formed. However, very little is known about what limits their formation despite an abundance of
molecular precursors. Using a forward genetic screen specifically designed to identify mutants with
increased meiotic crossover frequency (Crismani et al., Science 2012), we revealed that several
independent pathways limit crossover formation. Crossover frequency can be thus largely increased
without affecting meiotic chromosome segregation and fertility. This opens the possibility of
manipulating recombination for plant breeding and raises the question of the selection pressure that
maintains recombination at a low level in most eukaryotes.
12h00
En savoir plus : http://moulon.inra.fr/index.php/fr/news/79/217-seminaire-de-raphael-mercier-51214
Page 28
Date
Unité
Titre
Heure
DEPT OF DEVELOPMENTAL AND STEM CELL BIOLOGY ****
2014-2015 Seminar Series
Institut Pasteur
Paris 15ème
Claire Chazaud
UMR CNRS 6293 / INSERM U1103 / Clermont Université, Faculté de Médecine
Nanog, Gata6 and the Fgf pathway drive cell lineage specification in the blastocyst
12h00
Amphithéâtre Jacques Monod, sous-sol bâtiment Jacques Monod
Vendredi
05
SFR Necker
Inserm US 24 CNRS UMS 3633
Faculté Paris Descartes
JEAN PAUL BORG
CRCM Marseille
Erbin et polarité cellulaire
Bâtiment Leriche Porte 14
12h00
Page 29
Faculté Paris Descartes, Inserm U 1151 - Site Broussais - Amphithéâtre Leriche - Porte 10 - 14 rue
14 rue Maria Helena Vieira Da Maria Helena Vieira Da Silva - 75014 Paris
Silva
Invité(e) par Vincent Goffin
CS 61431
Date
Unité
Titre
Heure
Dr Diego Garcia-Ayuso
University of Murcia, Department of Ophthalmology, Optometry, Otolaryngology and Pathological
Anatomy
Vendredi 5
Institut de la Vision
17 rue Moreau - 75012 Paris
Retinal ganglion cell degeneration following photoreceptor degeneration
Invité par Serge Picaud
11h30
En savoir plus : http://www.institutvision.org/index.php?option=com_content&view=article&id=172%3Aseminaires&catid=2%3Ainstitut
-de-la-vision&Itemid=49&lang=fr
Page 30

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