TOC - The Journal of Experimental Medicine

Insights
2482
A novel immune regulator links malaria and inflammatory bowel
disease
Brandon K. Sack and Stefan H. Kappe
2482
2483
Stuart G. Tangye
THE
JOURNAL OF
EXPERIMENTAL
MEDICINE
Lymphocyte called home: β2-adreneric neurotransmission
confines T cells to lymph nodes to suppress inflammation
VOLUME 211 NUMBER 13
DECEMBER 15, 2014
www.jem.org
T cells require DOCK8 for flexibility and function
Kevin Tracey
2484
Sleeping our Alzheimer’s risk away
Ryan J. Watts
2485
CCR4 drives ATLL jail break
Kevin M. Shannon
Brief Definitive Reports
2487
Potential role of orexin and sleep modulation in the pathogenesis
of Alzheimer’s disease
Jee Hoon Roh, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito,
Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea,
and David M. Holtzman
2497
Gain-of-function CCR4 mutations in adult T cell leukemia/
lymphoma
Masao Nakagawa, Roland Schmitz, Wenming Xiao, Carolyn K. Goldman,
Weihong Xu, Yandan Yang, Xin Yu, Thomas A. Waldmann, and Louis M. Staudt
2507
Thromboxane A2 acts as tonic immunoregulator by preferential
disruption of low-avidity CD4+ T cell–dendritic cell interactions
Federica Moalli, Jovana Cupovic, Flavian Thelen, Pascal Halbherr, Yoshinori Fukui,
Shuh Narumiya, Burkhard Ludewig, and Jens V. Stein
Articles
2519
CCDC88B is a novel regulator of maturation and effector
functions of T cells during pathological inflammation
James M. Kennedy, Nassima Fodil, Sabrina Torre, Silayuv E. Bongfen,
Jean-Frédéric Olivier, Vicki Leung, David Langlais, Charles Meunier,
Joanne Berghout, Pinky Langat, Jeremy Schwartzentruber, Jacek Majewski,
Mark Lathrop, Silvia M. Vidal, and Philippe Gros
2537
Heterozygous splice mutation in PIK3R1 causes human
immunodeficiency with lymphoproliferation due to dominant
activation of PI3K
Carrie L. Lucas, Yu Zhang, Anthony Venida, Ying Wang, Jason Hughes,
Joshua McElwee, Morgan Butrick, Helen Matthews, Susan Price,
Matthew Biancalana, Xiaochuan Wang, Michael Richards, Tamara Pozos,
Isil Barlan, Ahmet Ozen, V. Koneti Rao, Helen C. Su, and Michael J. Lenardo
ON THE COVER
Beck et al. show that immature
B cell retention in the bone marrow is
an active process, whereas egress is
a passive one. B cells are retained in
the bone marrow by CXCR4-CXCL12
interactions, which induce ␣4␤1mediated adhesion to VCAM-1.
Decreased expression of CXCR4 in
B cells approaching sinusoids loosens
their grip and allows them to be
passively swept out of the marrow.
Image shows “rounded up” B cells
(blue) in sinusoids in the process of
passive exit. Image by New York artist
Alta Buden. alteration@gmail.com.
See page 2567
2549
DOCK8 regulates lymphocyte shape integrity for skin antiviral
immunity
Qian Zhang, Christopher G. Dove, Jyh Liang Hor, Heardley M. Murdock,
Dara M. Strauss-Albee, Jordan A. Garcia, Judith N. Mandl, Rachael A. Grodick,
Huie Jing, Devon B. Chandler-Brown, Timothy E. Lenardo, Greg Crawford,
Helen F. Matthews, Alexandra F. Freeman, Richard J. Cornall, Ronald N. Germain,
Scott N. Mueller, and Helen C. Su
2567
CXCR4 and a cell-extrinsic mechanism control immature B
lymphocyte egress from bone marrow
CCDC88B regulates neuroinflammation
See page 2519
Thomas C. Beck, Ana Cordeiro Gomes, Jason G. Cyster, and João P. Pereira
2583
Control of lymphocyte egress from lymph nodes through
β2-adrenergic receptors
Akiko Nakai, Yuki Hayano, Fumika Furuta, Masaki Noda, and Kazuhiro Suzuki
2599
The molecular bases of δ/αβ T cell–mediated antigen recognition
Daniel G. Pellicci, Adam P. Uldrich, Jérôme Le Nours, Fiona Ross, Eric Chabrol,
Sidonia B.G. Eckle, Renate de Boer, Ricky T. Lim, Kirsty McPherson, Gurdyal Besra,
Amy R. Howell, Lorenzo Moretta, James McCluskey, Mirjam H.M. Heemskerk,
Stephanie Gras, Jamie Rossjohn, and Dale I. Godfrey
2617
Bmi1 enhances skeletal muscle regeneration through MT1-mediated
oxidative stress protection in a mouse model of dystrophinopathy
Valentina Di Foggia, Xinyu Zhang, Danilo Licastro, Mattia F.M. Gerli, Rahul Phadke,
Francesco Muntoni, Philippos Mourikis, Shahragim Tajbakhsh, Matthew Ellis,
Laura C. Greaves, Robert W. Taylor, Giulio Cossu, Lesley G. Robson, and Silvia Marino
2635
Tespa1 negatively regulates FcεRI-mediated signaling and the
mast cell–mediated allergic response
Di Wang, Mingzhu Zheng, Yuanjun Qiu, Chuansheng Guo, Jian Ji, Lei Lei,
Xue Zhang, Jingjing Liang, Jun Lou, Wei Huang, Bowen Dong, Songquan Wu,
Jianli Wang, Yuehai Ke, Xuetao Cao, Yi Ting Zhou, and Linrong Lu
2651
Dynamic changes in E-protein activity regulate T reg cell
development
Ping Gao, Xiaojuan Han, Qi Zhang, Zhiqiong Yang, Ivan J. Fuss, Timothy G. Myers,
Paul J. Gardina, Fuping Zhang, and Warren Strober
2669
Cytomegalovirus generates long-lived antigen-specific NK cells
with diminished bystander activation to heterologous infection
Gundula Min-Oo and Lewis L. Lanier
Corrections
2681
RUNX1-dependent RAG1 deposition instigates human TCR-δ
locus rearrangement
Agata Cieslak, Sandrine Le Noir, Amélie Trinquand, Ludovic Lhermitte, Don-Marc
Franchini, Patrick Villarese, Stéphanie Gon, Jonathan Bond, Mathieu Simonin,
Laurent Vanhille, Christian Reimann, Els Verhoeyen, Jerome Larghero, Emmanuelle
Six, Salvatore Spicuglia, Isabelle André-Schmutz, Anton Langerak, Bertrand Nadel,
Elizabeth Macintyre, Dominique Payet-Bornet, and Vahid Asnafi
The molecular bases of δ/αβ T cell–
mediated antigen recognition
See page 2599
2683
Respiratory influenza virus infection induces intestinal
immune injury via microbiota-mediated Th17 cell–dependent
inflammation
Jian Wang, Fengqi Li, Haiming Wei, Zhe-Xiong Lian, Rui Sun, and Zhigang Tian
Bmi1 enhances skeletal muscle
regeneration through MT1-mediated
oxidative stress.
See page 2617