Getting to the core of research

Grant Calendar 2015
Getting to the core
of research
Find out how SingHealth’s core platforms and strategic programmes can work with
you to advance translational and clinical research.
Over the years, SingHealth’s research has made significant breakthroughs in medicine. In continuing efforts to
support impactful research, there is a need to invest extensively in the set-up of research infrastructure.
Currently, the SingHealth Office of Research has established 11 core platforms and research programmes, each
spearheaded by experienced researchers who share their expertise with collaborators and fellow researchers.
“Each core platform and programme is functionally distinct and aims to provide a unified one-stop access to all major
research protocols and contemporary instrumentations to facilitate translational medical research,” said Prof Hui
Kam Man, Deputy Group Director, Research (Translational Research and Core Platforms), SingHealth and Principal
Investigator, Division of Cellular and Molecular Research, National Cancer Centre Singapore.
Advanced Bio-imaging
• A state-of-the-art imaging platform for light and electron microscopy
• Specialises in super-resolution microscopy for conducting five types of imaging techniques
• Specialises in ultra-thin tissue sample preparation and imaging services for transmission
electron microscopy
Advanced Molecular Pathology Laboratory (AMPL)
• A one-stop pathology services facility for researchers and industry partners
• Addresses a pipeline of research needs from exploratory animal toxological studies to
biomarker discovery and validation of clinical research
Personalised OMIC Lattice for Advanced Research and Improving
Stratification (POLARIS)
• A stratified medicine initiative to deliver better patient outcomes through research
• Expertise in laboratory assays and standards, with capabilities in sequencing through
platforms such as the Next Generation Sequencing technology
• Forms collaborations in assay development validation for preclinical and early phase trial
testing assays
SingHealth Experimental Medicine Centre (SEMC)
• Closely linked to STR, facilitating access to high quality tissue bio resources
• Largest animal research centre in Singapore supporting research and training using both
small and large animal models
Clinical Pharmacology
• Provides comprehensive technical and veterinary services, protocol development and
logistics support for PI-initiated research
• Specialises in development and validation of GLP-compliant bio-analytical assays
• Expertise in designing and conducting pharmacogenomics studies
• Expertise in early phase clinical trial design and advanced pharmacokinetics/
pharmacodynamics modelling
Flow Cytometry
• Provides cell sorting and analysis services for research
• Equipped with state-of-the-art cytometers including cell analysers and cell sorters
• Capabilities in high speed acquisition and multi-parametric analysis • Focuses on novel healthcare technology solutions for unmet clinical needs
• Nurtures clinician-innovators through collaborations and networking, and provides them
opportunities to work on both home-grown and commercially viable projects
National Large Animal Research Facility (NLARF)
• Operates as a national resource through collaboration between SingHealth Duke-NUS
Academic Medical Centre and National University Health System
• The only AVA-approved international quarantine for non-human primates (NHPs) and pigs
in Singapore
• Provides supply and housing of research-quality local and imported NHPs and pigs, and
administrative and regulatory clearance services for importation
ASK A BURNING
CLINICAL
QUESTION
Your question should be
applicable to a clinical setting
Apply for a grant to generate pilot data to
strengthen your grant proposal
SEEK HELP WHEN
YOU ARE STUCK
Contact the Hub* with your problems
SingHealth Investigational Medicine Unit (IMU)
• A dedicated interventional early phase clinical research unit
• Supported by a team of SG-GCP-trained clinical research coordinators, clinical research
nurses and resident physicians
• Collaborates with SingHealth Clinical Phamacology on early phase clinical trial design and
advanced pharmacokinetics/pharmacodynamics modelling
SingHealth Tissue Repository (STR)
• Largest human tissue biobank in Singapore
Medical Technology Office (MTO)
NEED A
PILOT GRANT?
• Offers broad-based services including complex surgical and interventional research
WRITE YOUR
GRANT PROPOSAL
EARLY
Prepare your proposal early and
go through grant pre-review
COMPLY WITH
ETHICAL
GUIDELINES
Attend ethics courses before getting
IACUC or CIRB approvals
*Refer to Useful Contacts – Translational and Clinical Research Hub on Page 4 for contact details.
• Provides fresh tissue samples for cell line and xenograft construction, frozen tissue samples
stored in vapour phase liquid nitrogen, archive of paraffin embedded tissues and tissue
microarrays
• Tissue samples are harvested by pathology associates with minimum warm ischaemia
SingHealth Translational Immunology and Inflammation Centre
(STIIC)
• A translational research centre for clinically important immunology and inflammation
conditions, with emphasis on unmet clinical needs
• Uses the immunomics platform to study regulation of the immune system
• Aims to establish a network of researchers and clinicians, each contributing expertise to
drive successful grant applications
DEVELOP A
HYPOTHESIS
How can your untested theory help to
advance clinical solutions?
MEET
YOUR MENTOR
Discuss your hypothesis and research
plans with your mentor
COMPLETE YOUR
GRANT PROPOSAL
ON TIME
Incorporate the reviewers’ comments
before submission
BECOME AN
AMRI MEMBER
Benefit from the Academic
Medicine Research Institute’s (AMRI’s)
service offerings
MATCH TO
A MENTOR
Contact AMRI* or your institutional
research office for a suitable mentor
AWARDED
A GRANT?
Contact AMRI’s Post Award Guidance
Team* for guidance on getting your
research started
1
SingHealth Grant Calendar 2015
Award
Closing Month(s)
Amount
NMRC Clinician Scientist Award (CSA)
(I) Investigator (INV)
(II) Senior Investigator (SI)
Jun & Dec
Salary support1 + Research grant support
[ ≤$225K p.a. (INV) or ≤$350K p.a. (SI) ]
NMRC Transition Award (TA)
Jun & Dec
Salary support1 + Research grant support
(≤$375K)
Dec
Salary support for awardee
(≤$300K p.a.)
Jun & Dec
≤$500K
(inclusive of salary support & tuition fees
for part/full-time MSc/PhD and/or overseas training)
Mar
NMRC scholarship
Jun & Dec
≤$500K & ≤$800K
(inclusive of salary support & tuition fees
for local/overseas full-time PhD respectively)
NRF Fellowship
Mar
Research grant support
(≤$3M)
NRF Investigatorship
Mar
Research grant support
(≤$3M)
May & Oct
Salary support for awardee (≤$8K/mth) +
Research consumables for mentor ($20K)
Apr
SSB Fellowship
(inclusive of stipend, tuition fees & international travel support.
SingHealth Foundation Research Grant
(I) Start-up
(II) Transition Project
Sep
≤$50K (Start-up)
≤$150K (Transition Project)
SingHealth and Duke-NUS Research Collaborative Grant
Feb
≤300K
($150K for SingHealth Co-PI)
($150K for Duke-NUS Co-PI)
Khoo Mentored Research Award (KMRA)
Year-round
≤$300K
Khoo Pilot Award
Year-round
≤$30K
Khoo Student Research Award (KSRA)
Jun
≤$10K
MOH Communicable Diseases - Public Health Research Grant (CD-PHRG)
Dec
≤$1M
MOH Health Services Research Competitive Research Grant (HSR-CRG)
Jun
≤$200K & ≤$1M (two categories)
MOH Health Services Research New Investigator Grant (HSR-NIG)
Dec
≤$100K
Year-round (Cat 1)
Dec (Cat 2)
≤$500K; ≤$1M; ≤$1.5M (Cat 1: three subcategories)
≤$3M (Cat 2)
NMRC Clinician Scientist (CS)
(I) CS-Individual Research Grant (CS-IRG)
(II) CS-IRG-New Investigator Grant (CS-IRG-NIG)
Jun & Dec
≤$1.5M (CS-IRG)
≤$200K (CS-IRG-NIG)
(I) NMRC Cooperative Basic Research Grant (CBRG)
(II) CBRG-New Investigator Grant (CBRG-NIG)
Jun & Dec
≤$1.5M (CBRG)
≤$200K (CBRG-NIG)
Year-round (Co-D)
Jun & Dec (IIT)
≤$5M (Co-D)
≤$5M & ≤$2M (IIT: early & late phase)
NRF Competitive Research Programme (CRP)
May & Oct
Realistic quantum corresponding to scope of work
NRF Proof of Concept (POC) Grant
Feb & Aug
≤$250K
NHIC Innovation to Commercialisation (I2C) Grant
(I) Innovation to Protect (I2P)
(II) Innovation to Develop (I2D)
(III) Innovation to Implement (I2I)
Year-round
≤$40K (I2P)
≤$250K (I2D)
≤$1M (I2I)
BMRC-SERC Biomedical Engineering Programme (BEP)
(I) Proof of Concept (POC)
(II) Proof of Value (POV)
Dec
≤$500K (POC)
≤$1.5M (POV)
Singapore Heart Foundation Research Grant
Dec
≤$60K & ≤$80K (two categories)
Singapore Sports Science & Technology Research Grant (SSSTRG)
Apr
≤$50K; ≤$100K; ≤$200K; ≤$400K
(four categories)
Venerable Yen Pei-NKF Research Fund
Mar
≤$150K
National Talent Development
MOH/NMRC
NMRC Clinician Investigator Salary Support Programme (CISSP)
NMRC Research Training Fellowship
NMRC NUS Master of Clinical Investigation (MCI) Programme
Others
MOH Healthcare Research Scholarship
ExxonMobil-NUS Research Fellowship
Singapore-Stanford Biodesign (SSB) Fellowship Program
Duke-NUS
SingHealth
Foundation
Research Grants
Others
A*STAR
MOH/NMRC/NRF
MOH Industry Alignment Fund (IAF)
(I) Category 1
(II) Category 2
2
2
See NMRC website for salary support cap
PRE-REVIEW AND GRANT TIMELINE 2015
1
NMRC Clinical Trials Grant (CTG)
(I) Co-Development Scheme (Co-D)
(II) Investigator-Initiated Trials (IIT)
3
Exceptions for non-clinically qualified applicants (e.g. PhD holders) will be made on a case-by-case basis, subject to NMRC approval
NMRC/MOH MAY GRANT CALL
CSA, TA, CS-IRG/CS-IRG-NIG, CBRG/CBRG-NIG, HSR-CRG,
CTG (IIT & Co-D†), MOH IAF (Cat 1†),
NMRC Research Training Fellowship, MOH Healthcare Research Scholarship
OoR disseminates information to institutional RDOs:
(i) Upcoming grants
(ii) Requirements and deadlines for PIs’ proposals
#
to undergo pre-review by external reviewers
OoR disseminates information to institutional RDOs:
(i) Upcoming grants
(ii) Requirements and deadlines for PIs’ proposals to undergo
#
pre-review by external reviewers
Deadline for PIs to submit full
proposal (through institutional
RDO) to OoR/AMRI for pre-review
#
by external reviewers
GRANT CALL OPENS
2
Feb
23
Feb#
30
Mar#
20
Apr#
4
May
Deadline for PIs to
submit project title &
300-word abstract
(through institutional RDO)
to OoR/AMRI to identify
#
external reviewers
GRANT CALL closes
2
Jun*
3
Aug
GRANT CALL OPENS
24
Aug#
10
Aug
Deadline for PIs to submit project
title & 300-word abstract (through
institutional RDO) to OoR/AMRI to
#
identify external reviewers
#
Institutional RDO receives
pre-review feedback from
#
external reviewers
Pre-review process is mandatory for
i. CSA and TA submissions.
ii. NMRC Research Training Fellowship (PhD applications only) & MOH Healthcare Research Scholarship.
iii. First time applicants of any competitive national grants or those who have not received any competitive national grants before.
Those who have been awarded international funding previously will be considered on a case-by-case basis.
The pre-review process is optional for all others.
(i) CSA & TA: PI to submit via nGager for Research
Director’s (host institution) & Dean’s (Duke-NUS)
endorsements, after which application is automatically
routed to NMRC.
(ii) CS-IRG/CS-IRG-NIG, CBRG/CBRG-NIG, HSR-CRG,
CTG (IIT), NMRC Research Training Fellowship & MOH
Healthcare Research Scholarship: Submit directly via
nGager to NMRC.
SINGHEALTH FOUNDATION
RESEARCH GRANT
Start-up, Transition Project
For regular updates on new and upcoming grant calls, closing dates and other information, log on to http://research.singhealth.com.sg or look out for the SingHealth OoR e-bulletin issued every Tuesday. For support with grant applications or to be added to our
SingHealth Grant Calendar 2015
Eligibility Criteria
Citizenship
Funding (Years)
Research Focus
Singaporean (S),
Individual (I), Thematic (T),
Permanent Resident (PR),
Cross-Institution
Foreigner (F)
Collaboration (C-Inst)
MD, MBBS, BDS
(SMC-registered)
PhD
Non-PhD
(Scientists,
(Healthcare Professionals,
Healthcare Professionals,
Bio-statisticians and others)
Bio-statisticians and others)
Investigator’s Research Commitment
FTE/Faculty Appointment/Bond
3 (INV)
5 (SI)
S, PR, F
(must be PR at point of
award)
I
�
�2
≥0.5 FTE in research &
regular-rank faculty/academic appointment in
an AMC upon award
3
S, PR, F
(must be PR at point of
award)
I
�
(must have scientific
training at MSc/PhD level)
�2
≥0.5 FTE in research &
regular-rank faculty/academic appointment in
an AMC upon award
Commensurate with
existing active grant life
S, PR
I
�
2 (overseas training)
2 - 3 (MSc)
4 (PhD)
S, PR
I
�
2-3
S, PR
I
�
Bond duration
2.5 years
4
S, PR
I
�
(final year BST & above)
Bond duration
5 years (local PhD)
7 years (overseas PhD)
5
S, PR, F
I
5
S, PR, F
I
0.5 - 1
S, PR
I
�
0.5
S, PR, F
I,T
�
�
�
2
S, PR, F
I
�
�
�
2
S, PR, F
I, C-Inst
�
�
2
S, PR, F
I
�
�
≥0.3 FTE in research &
adjunct/regular-rank appointment in
Duke-NUS upon award
1
S, PR, F
I
�
�
Must hold AMRI membership & adjunct/regular-rank
appointment in Duke-NUS upon award
1
S, PR, F
I
Mentor (PI) must be Duke-NUS adjunct/regular-rank member;
Co-I must be Duke-NUS medical student.
3
S, PR, F
I, T
�
�
�
2
S, PR, F
I, T
�
�
�
2
S, PR, F
I, T
�
�
�
(min. Master’s degree)
2 (Cat 1)
3 (Cat 2)
S, PR, F
I
�3
�3
3 (CS-IRG)
2 (CS-IRG-NIG)
S, PR, F
I
�
�2
3 (CBRG)
2 (CBRG-NIG)
S, PR, F
I, C-Inst
�4
�
3
S, PR, F
T, C-Inst
�
5
S, PR, F
I
�
�
�
1
S, PR, F
I
�
�
�
1 (I2D)
2 (I2I)
S, PR, F
I
�
�
�
1 - 1.5 (POC)
1.5 - 2 (POV)
S, PR, F
T, C-Inst
�
�
�
2
S, PR, F
T
�
�
�
1-4
S, PR, F
T
�
�
1-3
S, PR
T
�
�
3
Requires collaboration between clinical PI and industry partner
0.1 - 0.6 FTE in research
�
GRANT CALL closes
14
Sep
28
Sep#
Participation is by nomination through the host university. Researchers holding joint
appointment with Duke-NUS and full-time faculty are eligible for nomination.
≥0.6 FTE in research
4
Legend
GRANT CALL OPENS
GRANT CALL closes
2
Nov
1
Dec*
21
Sep
Institutional
RDOs’ internal
deadline
Bond duration
Must work 2 years in Singapore upon completion
Exceptions for clinically qualified applicants (e.g. MBBS/MD/BDS holders) will be made on a case-by-case basis, subject to NMRC approval
Institutional RDO
receives pre-review
feedback from
#
external reviewers
19
Oct#
Bond duration
1.5 - 5 years (local MSc/PhD)
0 - 7 years (overseas research attachment/MSc/PhD)
�
NMRC/MOH NOVEMBER GRANT CALL
CSA, TA, CS-IRG/CS-IRG-NIG, CBRG/CBRG-NIG,
HSR-NIG, CD-PHRG, CTG (IIT & Co-D†), MOH IAF (Cat 1† & Cat 2),
NMRC Research Training Fellowship, MOH Healthcare Research Scholarship
Deadline for PIs to submit
full proposal (through institutional
RDO) to OoR/AMRI for
#
pre-review by external reviewers
�
(i) CSA & TA: PI to submit via nGager for Research Director’s (host institution) & Dean’s (Duke-NUS) endorsements,
after which application is automatically routed to NMRC.
(ii) CS-IRG/CS-IRG-NIG, CBRG/CBRG-NIG, HSR-NIG, CTG (IIT), NMRC Research Training Fellowship & MOH
Healthcare Research Scholarship: Submit directly via nGager to NMRC.
(iii) CD-PHRG: Submit directly via nGager to MOH.
(iv) IAF Cat 2: Submit via hard/softcopies through institutional RDO to NMRC.
A*STAR: Agency for Science, Technology and
Research
AMC: Academic Medical Centre
AMRI: Academic Medicine Research Institute
BDS: Bachelor of Dental Surgery
BEP: Biomedical Engineering Programme
BMRC: Biomedical Research Council
BST: Basic Specialist Training
CBRG: Cooperative Basic Research Grant
CBRG-NIG: CBRG - New Investigator Grant
CD-PHRG: Communicable Diseases - Public
Health Research Grant
CISSP: Clinician Investigator Salary Support
Programme
Co-D: Co-Development Scheme
Co-I: Co-Investigator
Co-PI: Co-Principal Investigator
CRP: Competitive Research Programme
CSA: Clinician Scientist Award
CS-IRG: Clinician Scientist - Individual Research
Grant
CS-IRG-NIG: CS-IRG - New Investigator Grant
CTG: Clinical Trials Grant
FTE: Full-Time Equivalent
HSR: Health Services Research
HSR-CRG: Health Services Research Competitive
Research Grant
HSR-NIG: Health Services Research - New
Investigator Grant
IAF: Industry Alignment Fund
IIT: Investigator-Initiated Trials
INV: Investigator
KMRA: Khoo Mentored Research Award
KSRA: Khoo Student Research Award
MBBS: Bachelor of Medicine, Bachelor of Surgery
MCI: Master of Clinical Investigation
MD: Doctor of Medicine
MOH: Ministry of Health
MSc: Master of Science
nGager: NMRC Grant Application and Grant
Evaluation for Research system
NHIC: National Health Innovation Centre
NMRC: National Medical Research Council
NKF: National Kidney Foundation
NRF: National Research Foundation
NUS: National University of Singapore
OoR: Office of Research
PhD: Doctor of Philosophy
PI: Principal Investigator
POC: Proof of Concept
POV: Proof of Value
RDO: Research Development Office
SERC: Science and Engineering Research Council
SI: Senior Investigator
SMC: Singapore Medical Council
SSB: Singapore-Stanford Biodesign
SSSTRG: Singapore Sports Science & Technology
Research Grant
TA: Transition Award
† Clinical Trial Grant Co-Development Scheme (CTG Co-D) and MOH Industry Alignment Fund Category 1 (MOH IAF Cat 1) are open for
application via nGager throughout the year but submissions for pre-review must follow the May & Nov pre-review timelines.
*
May and November grant call closing dates are estimated from historical information derived from NMRC and subject to change.
r research mailing list, please contact SingHealth Office of Research at 6576 7014/ 7013/ 7012 or office.research@singhealth.com.sg. This calendar is produced by SingHealth Office of Research and is accurate as of December 2014.
3
SingHealth Grant Calendar 2015
singhealth office of research
From grant application to managing intellectual property and supporting multi-institutional and multidisciplinary collaborations,
SingHealth Office of Research (OoR) has dedicated teams to support the research community.
GRANTS MANAGEMENT
RESEARCH OPERATIONS
finance operations
POLICY & STRATEGY
Manages the pre and post awards of
SingHealth Foundation grants to support
research careers; tracks, consolidates
and analyses SingHealth’s research key
performance indicators and output.
Manages the Academia’s research space
including laboratory and office spaces,
as well as the daily operations of shared
research facilities and services.
Manages finance matters and budgets for
research cost centres in SingHealth HQ.
Develops and implements research
strategies, manages research governance
matters and coordinates annual work plans
and retreats.
Best known for:
Best known for:
Best known for:
Best known for:
• Managing SingHealth Foundation Grants
• Being the go-to team for information on
eligibility criteria for various grants
• Coordination for and development of
the grant management system
• Planning and developing new laboratory
space and research core platforms in
the Academia’s Discovery Tower
• Coordinating research continuity plans
and advising on lab safety matters in
the Discovery Tower
• Managing the Discovery Tower’s
shared facilities
IACUC SECRETARIAT
intellectual Property
• Reviewing and developing core
platforms’ business and
charging models
• Providing financial projections
for strategic proposals
• Managing research budgets for
research units in SingHealth HQ
• Developing and implementing the
SingHealth and Duke-NUS Joint
Research Masterplan
• Developing Phase III proposal for
Office of Clinical Sciences/AMRI
• Developing AMCs’ proposal to MOH in
preparation for Research, Innovation
and Enterprise 2020
PROJECT MANAGEMENT &
RESEARCH COLLABORATIONS
RESEARCH outreach
Supports the Institutional Animal Care and
Use Committee (IACUC) on administrative
matters; liaises with PIs to ensure protocols
comply with international best practices and
animal ethics.
Protects SingHealth’s intellectual property
(IP) assets such as patents, trademarks,
or in contracts such as Research
Collaboration Agreements, as well as
commercialises IP through licensing
patents to industry.
Develops and implements research
communications plans; manages the
research website, research e-bulletins and
research branding. Assists core platforms
and research programmes on publicity and
communication matters.
Supports and manages research
collaboration projects between
SingHealth and external collaborators,
including the formation of new
collaborations up to the full execution
of the collaborative agreements.
Best known for:
Best known for:
Best known for:
Best known for:
• Supporting AAALAC re-accreditation of
SEMC, which is the international gold
standard for high quality humane animal
care and use in research and teaching
• Processing IACUC applications
• Being the go-to resource on IP matters
• Advising on patenting process,
commercialisation and
IP related matters
• Reviewing Research Collaboration
Agreements and IP clauses
in agreements
• Branding of SingHealth Research
• Developing core platforms’ and
programmes’ communication collaterals
• Publishing weekly research e-bulletins
and organising research grand rounds
• Supporting the formation of POLARIS,
AMPL and STIIC
Useful contacts – TRANSLATIONAL AND CLINICAL RESEARCH HUB
The Hub works with Academic Clinical Programs and institutions to provide translational and clinical research support to SingHealth and Duke-NUS researchers,
with particular focus on developing clinician scientists, scientists and research support professionals.
Core Platforms and Research Strategic Programmes
OoR – Grant Administration
Dr Si-Hoe San Ling
6576 7012
si.hoe.san.ling@singhealth.com.sg
Ms Tan Yi Mei
6576 7013
tan.yi.mei@singhealth.com.sg
Ms Iris Soh
6576 7014
iris.soh.s.j@singhealth.com.sg
Centralised Institutional Review Board (CIRB)
6323 7515
irb@singhealth.com.sg
Institutional Animal Care and Use Committee (IACUC)
Ms Serene Lok
6576 7015
iacuc@singhealth.com.sg
6377 8533
cindy.goh.j.e@sgh.com.sg
SingHealth Intellectual Property (SHIP)
Mr Koh Choon Heng
6576 7022
koh.choon.heng@singhealth.com.sg
Academic Medicine Research Institute (AMRI)
General enquiries
amri_info@duke-nus.edu.sg
iSHaRe
iSHaRe support
SingHealth Clinical Pharmacology
6576 7020
ishare@singhealth.com.sg
bioimaging@singhealth.com.sg
clin.pharm@singhealth.com.sg
SingHealth Experimental Medicine Centre (SEMC) and
National Large Animal Research Facility (NLARF)
General enquiries
6576 7041
SingHealth Flow Cytometry
General enquiries
SingHealth Investigational Medicine Unit (IMU)
Institutional Biosafety Committee (IBC)
Ms Cindy Goh
General enquiries
General enquiries
Compliance & Ethics
General enquiries
SingHealth Advanced Bio-imaging
General enquiries
shs.semc@singhealth.com.sg
flow@singhealth.com.sg
imu@singhealth.com.sg
SingHealth Tissue Repository (STR) and
Advanced Molecular Pathology Laboratory (AMPL)
General enquiries
SingHealth Medical Technology Office (MTO)
General enquiries
ampl@singhealth.com.sg
mto@singhealth.com.sg
SingHealth Translational Immunology & Inflammation Centre (STIIC)
General enquiries
STIIC@singhealth.com.sg
Personalised OMIC Lattice for Advanced Research and
Improving Stratification (POLARIS)
General enquiries
4
This research special is brought to you by SingHealth Office of Research.
polaris@singhealth.com.sg