Hyoscine Butylbromide

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Hyoscine Butylbromide
Anticholinergic
C21H30BrNO4 = 440.4
CAS—149­64­4
IUPAC Name [7(S)­(1α,2β,4β,5α,7β)]­9­Butyl­7­(3­hydroxy­1­oxo­2­
phenylpropoxy)­9­methyl­3­oxa­9­azoniatricyclo[3.3.1.02,4]nonane bromide
Synonyms Butylscopolamonii bromidum; hyoscine­N­butyl bromide;
scopolamine butylbromide.
Proprietary Name Buscopan
Chemical Properties A white crystalline powder. Mp 140° to 144°. Soluble 1 in 1
of water, 1 in 50 of ethanol and 1 in 5 of chloroform; practically insoluble in ether.
Log P (octanol/water), −1.1.
Colour Tests Aromaticity (method 2)—colourless/yellow; Liebermann's reagent—
orange.
Thin­layer Chromatography System TA—Rf 0.08 (acidified iodoplatinate
solution, positive).
High Performance Liquid Chromatography System HY—RI 294.
Ultraviolet Spectrum Aqueous acid—252 (A11 =3.7a), 258 (A11 =4.6a), 264 nm
(A11 =3.6a).
Infrared Spectrum Principal peaks at wavenumbers 1175, 1721, 1052, 874,
1072, 709 cm−1 (Nujol mull).
M Account
Disposition in the Body Poorly absorbed after oral administration. About 90% of
an oral dose is eliminated in the faeces and <10% is excreted in the urine. After
IV administration, about 40% of a dose is excreted in the urine.
Half­life Plasma half­life, about 8 h.
Protein Binding About 10%.
Dose 20 mg given parenterally, repeated if necessary; 80 mg daily, orally.
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See Also
AHFS Drug Information
(2)
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Hydrobromide (EENT)
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Symptom control
Continuous
subcutaneous
infusions
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BNF for Children (10)
Symptom control
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subcutaneous
infusions
Antimuscarinics
see all (10)
Clarke's Analysis of
Drugs and Poisons (3)
Hyoscine
Hyoscine
Methobromide
Hyoscine Methonitrate
Handbook on
Injectable Drugs (2)
Scopolamine
Butylbromide
Scopolamine
Hydrobromide
Injectable Drugs Guide
(3)
Hyoscine
butylbromide
(scopolamine
butylbromide)
Hyoscine
hydrobromide
(scopolamine
hydrobromide)
Papaveretum with
hyoscine
hydrobromide
Martindale: The
Complete Drug
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Cimetropium Bromide
Hyoscine
Belladonna
see all (5)
Remington: The
Science and Practice of
Pharmacy
Scopolamine
Hydrobromide
Stockley's Herbal
Medicines Interactions
(2)
Angel's trumpet
Henbane
Stockley's Drug
Interactions
Interactions of
Hyoscine
Drug Administration via
Enteral Feeding Tubes
(2)
Hyoscine
butylbromide
Hyoscine
hydrobromide
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